CN104623374A - Traditional Chinese medicine preparation for treating acute radiation sickness and preparation method of traditional Chinese medicine preparation - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating acute radiation sickness. The traditional Chinese medicine preparation is prepared from the following raw materials by certain ratio: American ginseng, polygonatum odoratum, cerealose, longan pulp, atractylodes, poria cocos, rhizoma alismatis, lotus root juice, dark plum, mongolian snake gourd root, corn stigma, rhizoma phragmitis, lalang grass rhizome, turtle shell, tortoise plastron, pulp of cornus, adenophora tetraphylla, polygonum multiflorum, donkey-hide glue, dendrobium, wolfberry fruit, herba pyrolae, polygonatum kingianum, human placenta, anemarrhenae, flatstem milkvetch seed and raw liquorice. The traditional Chinese medicine preparation has the efficacies of tonifying qi, nourishing yin, clearing heat, promoting secretion of body fluid, invigorating the heart and spleen, cooling blood and stopping bleeding, and is significant in treatment effect.

Description

A kind of Chinese medicine preparation for the treatment of acute radiation sickness and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for the treatment of acute radiation sickness, the invention still further relates to the preparation method of this Chinese medicine preparation.

Background technology

Acute radiation sickness (acute radiation disease) is the systemic disease that body is subject to heavy dose (> 1Gy) ionization radiation irradiation at short notice and causes, all may there is acute radiation sickness in external exposure and internal radiation, but based on external exposure.External exposure causes the ray of acute radiation sickness to have γ line, neutron and X-ray etc.The pathogenetic condition of general acute radiation has following several situation: 1, nuclear war period, exposure during below 101kt nuclear explosion and have shielding personnel, more than 101kt explosion time have shielding personnel, the personnel passing through in serious contaminated area and overstay, be subject to the external exposure of early nuclear radiation or radioactive contamination, it is the principal element that a large amount of acute radiation sickness wounded occur, 2, Nuclear Accidents, nuclear power station runs improper or nuclear leakage and large areas can be caused to suffer from acute radiation injury disease, 3, malpractice, the medical applications of radionuclide and radiation appliance, also likely there is malpractice.Producing the lethal accident of internal radiation acute radiation as once there is the excessive radio nuclide therapy patient of misuse abroad, also once occurring because radiation appliance fault makes patient be subject to the accident of excessive exposure.4, therapeutic irradiation, gives patient high-dose irradiation because treatment needs, can cause therapeutic acute radiation sickness.As heavy dose of (> 6Gy) total irradiation conventional before bone marrow transplantation or lymph nodes of body as a whole irradiate, as the pretreatment before bone marrow transplantation.

The cardinal symptom of radiation sickness has: fatigue, giddy, insomnia, skin rubefaction, ulcer, hemorrhage, alopecia, leukemia, vomiting, diarrhoea etc., sometimes cancer, distortion, heritability pathological changes incidence rate can also be increased, affect the health of several generations, in general, the emittance that health accepts is more, its radiation sickness symptom is more serious, carcinogenic, teratogenesis risk is larger.If radiation sickness is BM form symptom, what first occur is exactly hemopoietic damage, and hematopoietic cell reduces, blood sinus oozing of blood, hemorrhage, does not treat for a long time and hemopoietic function even can be caused not recover voluntarily.

Increasing of current amiable nuclear power station, and inevitable some malpracticees, acute radiation sickness also causes the concern of people gradually, but does not have what specific drug for acute radiation sickness at present, and also many patients still endure the puzzlement of disease to the fullest extent.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of acute radiation sickness, it is obvious, cheap that this Chinese medicine preparation has curative effect for acute radiation sickness, safe ready, the little feature of side effect.

Inventor is in clinical treatment practice for many years, according to the feature of this disease, and the combination principle of Chinese medicine, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of acute radiation sickness repeatedly, the present invention selects Radix Panacis Quinquefolii, Rhizoma Polygonati Odorati, maltose, Arillus Longan, Rhizoma Atractylodis, Poria, Rhizoma Alismatis, Rhizoma Nelumbinis juice, Fructus Mume, Radix Trichosanthis, Stigma Maydis, Rhizoma Phragmitis, Rhizoma Imperatae, Carapax Trionycis, Carapax et Plastrum Testudinis, Fructus Corni, Radix Adenophorae, Radix Polygoni Multiflori, Colla Corii Asini, Herba Dendrobii, Fructus Lycii, Herba Pyrolae, Rhizoma Polygonati, Placenta Hominis, the Rhizoma Anemarrhenae, Semen Astragali Complanati, Radix Glycyrrhizae combines, each efficacy of drugs is made by these drug regimens to produce synergism, make it that there is boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, invigorating the heart and spleen, effect of cooling blood for hemostasis, can effectively alleviate and treat acute radiation sickness.

The effect of Chinese medicine of the present invention:

Wherein:

Radix Panacis Quinquefolii: be the dry root of Araliaceae Radix Panacis Quinquefolii Panax quinquefolium L..Nature and flavor: sweet, micro-hardship are cool.GUIXIN, lung, kidney channel.Effect: boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for deficiency of vital energy the moon, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, dryness of the mouth and throat." book on Chinese herbal medicine asks former ": lung qi this in kidney, the medicine of all lung benefiting gas, multi-band is slightly cold, but this then bitter cold, and only fire is contained and felt frustrated, and cough expectorant blood, impairment caused by overstrain consumption of essence person should it.

Rhizoma Polygonati Odorati: be the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce.Nature and flavor: sweet, are slightly cold.Attach to the lung and stomach meridians.Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.This product sweet in the mouth, greasiness, soft and moist edible, be longer than yin nourishing, mainly act on taste, therefore take not imapirment of the spleen and stomach for a long time, cure mainly the few expectorant of dry cough caused by deficiency of lung-YIN, pharynx dryness of the tongue and epidemic febrile disease later stage, or Tianjin of occurring is few thirsty, inappetence, the diseases such as stomach discomfort because hyperpyrexia consumption impairment of body fluid liquid.The merit that this product is mended and oiliness, cold not dry, therefore has " tonification the five internal organs, nourish QI and blood, flat benefit and moistening, and hold concurrently except wind heat ", has the effect of nourishing calm neural and heart tonifying.Be applicable to cardiopalmus, angina pectoris.Confirm through modern medicine study, Rhizoma Polygonati Odorati also has hypoglycemic activity, also has moist skin, and the effect of spraining is got injured by a fall in dissipation skin chronic inflammatory disease and treatment.

Maltose: by rice or other starch materials, after dipping cooks, adds Fructus Hordei Germinatus, makes it ferment, then add water and decoct, all sugars of stripping, filtering slag, concentrated, maltose.Nature and flavor: sweet, temperature.Return spleen, stomach, lung meridian.Effect: in slow, tonify deficiency, promotes the production of body fluid, and moisturizes.Control overstrain impairing the spleen, pain in the abdomen is suffered from abdominal pain, xeropulmonary cough, spits blood, thirsty, pharyngalgia, constipation." Bencao Jingshu ": maltose, sweet flavour enters the spleen, and rice wheat all supports the thing of taste, therefore main tonify deficiency is weary, in Zhong Jingjian, soup is also with it.Lung stomach has fire then to send out yearningly, and scorching on fire, the absurd row of forcing blood is then spitted blood, sweet can delay fire when, then fire declines and thirsty from only, and blood is from going also.

Arillus Longan: be the aril of Sapindaceae Euphoria plant Arillus Longan Dimocarpus longan Lour..Nature and flavor: sweet, temperature.GUIXIN, spleen channel.Effect: invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion." detailed outline ": food with Fructus Litchi for expensive, provide benefit then Arillus Longan be good, lid Fructus Litchi is hot in nature, and Arillus Longan property peace is also.Tight use and recipes for Saving Lives are controlled and are pondered over impairment caused by overstrain heart spleen and have GUIPI TANG, get sugariness and return spleen, can the justice of beneficial people's intelligence.

Rhizoma Atractylodis: be the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Nature and flavor: pungent, bitter, temperature; Return spleen, stomach, Liver Channel; Effect: drying damp and strengthening spleen, expelling wind and cold, improving eyesight; This product toil is warm in nature, and virtue is strong dry loose, and can rise and can fall, walk and do not keep, can be that damp is removed and recovers the transportation capabilities of spleen.

Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Sweet the providing additional supplies of this product is oozed, and not only mends but also sharp, and effect is gentle, and property is flat and partially without cold and heat, is the key medicine of promoting diuresis to eliminate damp pathogen.Poria decoct has obvious sedation." modality ": " cure mainly Ji Rou Shun muscle of throbbing with fear cautious, dizziness agitation is controlled on side." this product is by heart-spleen boosting and tranquilizing mind.Be used for deficiency of both the heart and spleen, the irritability of insufficiency of vital energy and blood.

Rhizoma Alismatis: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis Alisma orientalis (Sam.) Juzep..Nature and flavor: sweet, cold.Return kidney, urinary bladder channel.Effect: diuresis, clearing away damp-heat.For edema, the dysuria of retention of water-damp in the body.Rhizoma Alismatis and the same use of the Rhizoma Atractylodis Macrocephalae, what can be used for harnessing the river caused by damp-phlegm drink is dizzy.This product enters kidney, urinary bladder channel, kind clear damp-heat in lower-JIAO cold in nature.In addition to staphylococcus aureus, Diplococcus pneumoniae, tubercule bacillus has inhibitory action.This product enters kidney, urinary bladder channel, and Rhizoma Alismatis has significant diuresis, can promote muriatic excretion, increases urine volume, has blood pressure lowering, hypoglycemic activity, also has lipotropic effect.

Rhizoma Nelumbinis juice: be the loose rhizome of nymphaeaceae plant lotus Nelumbo nucifera G., Rhizoma Nelumbinis juice is the juice that it breaks into.Nature and flavor: flat, sweet, puckery.Gui Jing: stomach, liver, kidney.Effect: hemostasis, dissipating blood stasis.Control hemoptysis, spit blood, epistaxis, hematuria, has blood in stool, dysentery, metrorrhagia.The sweet adstringency of this product is put down, can astringing to arrest bleeding, again can dissipating blood stasis blood, and have the advantages that the stasis of blood is not stayed in hemostasis, only the efficacy of a drug is more slow, is often used as to assist hemorrhage.The joint portion of Rhizoma Nelumbinis.For epistaxis, hemoptysis, spit blood, have blood in stool, hematuria and woman uterine bleeding, person is the most suitable to have blood stasis to lose blood.Alone, or the medicine that compatibility is suitable.

Fructus Mume: be the dry almost ripe fruit of rose department plant plum Prunus mume (Sieh.) Sieb.et Zucc..Nature and flavor: sweet, sour, puckery, warm.Return stomach, large intestine channel.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.This product is used for not closing up for a long time after carbuncle sore is burst, and external has the effect of removing dampness expelling pus and promoting granulation." Bencao Jingshu ": Fructus Mume, namely the Fructus Mume of the present is also, the sourest." warp " is said: heat impairing vital QI, and evil visitor is in the heart, then gas superinverse and stuffy sensation with restlessness, the heart is uneasy for it.Fructus Mume sour in the mouth, can hold back superficial heat, air-breathing can return unit, therefore the main therapeutic method to keep the adverse QI flowing downwards, heat extraction stuffy sensation with restlessness and feeling at ease also.Dysentery person, large intestine collapse is also; Good saliva xerostomia person, hyperactivity of deficient fire, deficiency of body fluid is also; Acid can hold back asthenic fire, change body fluid, solid intestinal take off, so lead also.Its main limb pain, hemiplegia meciless person, covers because dampness is dipped in meridians, then muscle arteries and veins relaxes vertical, or pain is meciless; Liver governing tendons, sour in taste acting on the liver and nourishing muscle and tendon, liver obtain support, then solid skeleton and pliable tendons, machine-operated tonneau and front card removes.

Radix Trichosanthis: be the dry root of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms Trichosan-thes rosthornii Herms.Nature and flavor: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Effect: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.For carbuncle skin infection.This product has detumescence effect to the skin infection person that do not burst, and pus of bursting goes out impassable patient and has evacuation of pus effect, also has clearing away lung-heat and moistening for dryness, effect of quenching one's thirst of promoting the production of body fluid.

Stigma Maydis: be style and the fresh idea of grass family Zea plant Zea mays Zea mays L..Nature and flavor: sweet, light are flat.Return bladder, liver, gallbladder meridian.Effect: inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice.And can habitual abortion be prevented.In addition, this product develops to some extent in recent years in clinical practice, is usually used in the diseases such as diabetes, hypertension, hepatitis, Biliary Calculi, rhinitis and asthma." modern Practical Chinese medicinal ": be diuretic, effective to nephropathy, edema illness, diabetes etc.It is again the active drug of cholecystitis, cholelithiasis, hepatic inflammatory jaundice etc.

Rhizoma Phragmitis: be the fresh or dry rhizome of grass phragmites communis Phragmites communis Trin..Nature and flavor: sweet, cold.Return lung meridian, stomach warp.Function: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.This product often coordinates Radix Ophiopogonis, Radix Trichosanthis with clearing away heat and promoting production of body fluid; Join Caulis Bambusae In Taenia, Folium Eriobotryae with clearing away heat to stop vomiting; Rhizoma Phragmitis one medicine, is mainly used in following two aspects clinically, can clearing away lung-heat and evacuation of pus of eliminating the phlegm, again can clearing away stomach-heat and the preventing or arresting vomiting that promotes the production of body fluid.Though its attribute is trembled with fear, slightly sweet flavor and power use lung heat clearing stomach, can only as auxiliary medicine.But, it has an advantage, and namely property is not grown greasy, promotes the production of body fluid and does not love heresy, and all epidemic febrile disease deep loves are defended, gas, or if any the syndrome that impairment of body fluid is thirsty after calentura, all can apply.

Rhizoma Imperatae: be the rhizome of grass perennial herb Herba Imperatae Imperata cylindrica.Nature and flavor: sweet, cold.Return lung, stomach, urinary bladder channel.Effect: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema." Bencao Jingshu " is recorded: impairment caused by overstrain void is won, must interior-heat, and Rhizoma Imperatae is sweet can spleen reinforcing, sweet, though cold and do not violate stomach.Gan Hanneng is except interior-heat, therefore main impairment caused by overstrain void is won.Strengthening the spleen so invigorating middle warmer, heat extraction so QI invigorating, the beneficial blood of sweet energy, heat in blood is the stasis of blood then, and the stasis of blood is then closed, and closes then cold and heat and does, cold and cool blood, sweet beneficial blood, heat go then blood and, and then stagnation resolvation and close logical, general rule cold and heat are from only also.Dysuria, due to interior-heat also, pyrolysis then just diarrhea.Pouring person, caused by blood system deficiency-heat also, removing heat from blood benefit blood, then drench spontaneous recovery, and the exopathogenic heat of the intestines and stomach is explained by oneself, and body fluid is raw and yearningly also stop.Blood stored in the liver and main muscle, cool liver of enriching blood, then muscle is hard.Heat in blood then collapses, and removing heat from blood and blood, then collapse spontaneous recovery.Heat in blood is absurd row then, overflow upper orifices for telling, for coughing up, be epistaxis, bleeding from the gum, removing heat from blood and blood, then all cards are from removing.Strengthening the spleen invigorating middle warmer, diuresis, therefore swollen jaundice of also harnessing the river, and hold concurrently reason typhoid fever hiccup also.

Carapax Trionycis: be the carapace of Trionychidae animal Trionyx sinensis Wiegmann Trionyx sinensis Wiegmann.Nature and flavor: salty, are slightly cold.Return liver, kidney channel.Effect: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.Radix Stellariae compatibility Carapax Trionycis Radix Stellariae is sweet cold, clearing away heat and cooling blood, reducing the asthenic fever, except hectic fever due to YIN-deficiency; Carapax Trionycis is salty-cold, nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming. Papillary, and play replenishing YIN and removing heat altogether except effect of steaming, be used for the treatment of fever due to yin deficiency, hectic fever due to YIN-deficiency, infantile malnutrition; Or the calentura later stage, waste heat not to the greatest extent person.

Carapax et Plastrum Testudinis: be sternite and the carapace of Testudinidae animal chinemys reevesii.Nature and flavor: salty, sweet, be slightly cold.Return liver, kidney, heart channel.Effect: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, Gu through only collapsing, reinforcing the heart of nourishing blood.Carapax et Plastrum Testudinis contains several amino acids, protein, fat and calcium salt etc. containing bone gelatin, hydrolysate.Cure mainly hyperactivity of YANG due to deficiency of YIN, yin asthenia generating intrinsic heat, stirring-up of pathogenic wind in the interior resulting from deficiency.To suffer from a deficiency of the kidney the atrophic debility of bones, infantile metopism.Deficiency of YIN-blood, palpitation with fear, insomnia, forgetful.This product energy tonifying kidney-yin is appointed with Gu Chong, again heat clearing away cold in nature, and holding concurrently can cooling blood for hemostasis.For the menorrhagia of YinXuXueRe, metrorrhagia and metrostaxis.This product can nourish blood reinforcing the heart, can be used for insomnia forgetfulness.

Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb.et Zucc..Nature and flavor: sour, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly and have a dizzy spell, deafness and tinnitus, soreness of the waist and knees, emission and spermatorrhea, frequent micturition, incessant sweating due to debility, woman uterine bleeding.Fructus Corni tepor is not dry, mends and not high, can flat nourishing YIN sun, supports the flourish muscle of marrow, by treating the liver kidney deficiency is commonly used.The sour-puckery flavor of Fructus Corni, can restrain solid de-, all gas body fluid persons of decoherencing, and available this product, with needed for card, is equipped with the same use of the medicine effected a permanent cure.As yang deficiency after being ill, space between skin and muscles is solid, sweating on the whole body person, and all hyperhidrosis vigour of controlling is for de-person, and this product is the medicine that must use.

Radix Adenophorae: be the dry root of Campanulaceae adenophora tetraphylla Adenophora tetraphylla (Thunb.) Fisch. or Radix Adenophorae (Radix Glehniae) Adenophora stricta Miq..Nature and flavor: sweet, are slightly cold.Attach to the lung and stomach meridians.Effect: nourishing YIN and clearing away lung-heat, reduces phlegm, QI invigorating.For lung-heat type cough, deficiency of YIN chronic cough, dry cough expectorant sticks, deficiency of both vital energy and Yin, restlessness and fever with thirst." detailed outline ": Radix Ginseng sweetness and bitterness temperature, its body weight is real, special tonifying the spleen and stomach vigour, thus lung benefiting and kidney, therefore internal injury vigour person should it.Radix Adenophorae (Radix Glehniae) is sweet light and cold, and its body is gently empty, special tonifying the lung gas, thus strengthening the spleen and kidney, therefore gold should it by fire gram person.One YANG invigorating and raw cloudy, a nourishing YIN and sun processed, must distinguish also.

Radix Polygoni Multiflori: be the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb..Nature and flavor: bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Effect: blood enriching and generation of vital essence promoting, removing toxicity for eliminating carbuncles, loosening bowel to relieve constipation.The main benefit of Radix Polygoni Multiflori sweet in the mouth, is longer than tonifying liver blood, kidney tonifying essence, bone and muscle strengthening.Hair is the sign of blood condition, the institute of kidney is flourish, and essence and blood must fill, then kind black beard and hair.Radix Polygoni Multiflori Preparata, the main punching of kidney is appointed, the liver department sea of learning, the liver and the kidney tonifying, strengthening the body resistance.Compendium of Materia Medica ": Radix Polygoni Multiflori, white person enters edema caused by disorder of QI, and red person enters blood system.Kidney master closes Tibetan, liver controlling conveyance and dispersion, this thing temperature bitter and puckery flavor, bitter the kidney invigorating, and temperature compensation liver, can restrain vital essence, so the liver benefiting that can nourish blood, controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black hair is tonic medicine, and cold not dry, merit is on Radix Rehmanniae, all medicines of Radix Asparagi.QI and blood Taihe county, then wind void, carbuncle, all diseases of scrofula known (removing).

Colla Corii Asini: for the skin of equine species donkey Equus Asinus L. is through decocting, concentrating the solid gum made.Nature and flavor: sweet are flat.Return lung, liver, kidney channel.Effect: YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy." detailed outline ": Colla Corii Asini, will just enrich blood and liquid greatly, therefore can lung heat clearing tonifying YIN and control all cards.By Chen Ziming cloud: tonify deficiency animal glue, remove wind Colla Corii Asini.Cheng Wuji cloud: deficiency of YIN person, tonifying with drugs of thick flavor, Colla Corii Asini sweet, with nourishing YIN blood.Yang Shiying cloud: all control to breathe heavily cough, no matter the deficiency of the lung, excess of the lung, can under can temperature, palpus Colla Corii Asini is to pacify lung lung moistening, and its property is peaceful, is lung meridian key medicine.

Herba Dendrobii: be the fresh or dry stem of orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., Herba Dendrobii oculati Dendrobium fimbriatum Hook.var.oculatum Hook., HERBA DENDROBII Dendrobium chrysanthum Wall., Herba Dendrobii Dendrobium candidum Wall.ex Lindl. or Dendrobium nobile Dendrobium nobile Lindl..Nature and flavor: be slightly cold; Sweet.Return stomach, kidney channel.Function: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.Herba Dendrobii has obvious therapeutical effect to ophthalmic diseases." explaining abstruseness of the canon of materia medica ": Herba Dendrobii, Gan Keyue spleen, salty energy kidney tonifying, therefore many merits are dirty in water and soil two.But gas is wide slow, without the merit that victory is played, ancients with this tea in generation, very clearly on diaphragm.

Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor: sweet, flat.Return liver, kidney channel.Effect: nourishing the liver and kidney, replenishing vital essence to improve eyesight.Cure mainly: caused by liver and kidney deficiency; Have a dizzy spell; Visual unclear; Soreness of the waist and knees; Impotence and seminal emission; Cough due to consumptive disease; To quench one's thirst taking fluids profusely.Fructus Lycii contains the required nutrition of the healthy eye such as calcium, ferrum such as abundant carotene, retinol1, B1, B2, C, therefore is good at improving eyesight, and the blurring of vision that ancient Chinese medicine doctor treatment deficiency of liver-blood, deficiency of kidney-YIN cause and nyctalopia, usually use Fructus Lycii.Fructus lycii extracted solution has delaying senility function and function for tonifying kidney.

Herba Pyrolae: be the dry herb of Pyrolaceae plant Herba pyrolae japonicae Pyrola calliantha H.Andres or ovum leaf Herba pyrolae japonicae Pyrola decorata H.Andres.Nature and flavor: sweet, bitter, temperature.Return liver, kidney channel.Effect: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.Be mainly used in labor void clinically.

Rhizoma Polygonati: be the dry rhizome of liliaceous plant P. kingianum Polygonatum kingianum Coll.et Hemsl., Rhizoma Polygonati Polygonatum sibiricum Red. or Polygonatum cyrtonema Hua Polygonatum cyrtonema Hua.Nature and flavor: sweet are flat.Return spleen, lung, kidney channel.Effect: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst." book on Chinese herbal medicine is just read ": Rhizoma Polygonati, for growing greasy product, clothes of a specified duration make us not hungry, have wet person if insufficiency of the spleen, should not take it, and probably its greasy diaphragm also.These flavour of a drug are sweet as maltosemalt sugar, and the flat matter profit of property is the certified products of tonic spleen the moon.

Placenta Hominis: be the dry Placenta Hominis of Healthy People.Fresh human placenta being removed amniotic membrane and umbilical cord, repeatedly rinsing to removing blood, after steaming or putting and slightly boil in boiling water, dry.Nature and flavor: sweet, salty, temperature.GUIXIN, lung, kidney channel.Effect: the kidney warming mends essence, benefiting QI and nourishing blood.For asthenia weakness and emaciation, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia.Can be used for disease such as treatment bronchial asthma, chronic bronchitis etc. clinically." herbal classic is met former ": Placenta Hominis possess essence and blood knot pregnant after liquid, obtain female QI and blood in the majority, therefore can high benefit nutrient blood, in order to control hectic fever due to YIN-deficiency weakness and emaciation, breathe heavily the disease of asthenia of coughing, be tonifying with drugs of thick flavor also.

The Rhizoma Anemarrhenae: be the dry rhizome of liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge..Nature and flavor: bitter, sweet, cold.Return lung, stomach, kidney channel.Effect: clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.For fever due to yin deficiency, cough due to consumptive disease and the disease such as to quench one's thirst.

Semen Astragali Complanati: be the dry mature seed of leguminous plant astragatus complanatus Astragalus complanatus R.Brown..Nature and flavor: sweet, warm.Return liver, kidney channel.Effect: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision." Gu Shi cures mirror " cloud: this product " special the kidney invigorating of reinforcing YIN-essence controlling nocturnal emission with astringent drugs, merit." Semen Astragali Complanati benefit essence and random sun, YANG invigorating and not random body.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, flat.GUIXIN, lung, spleen, stomach warp.Effect: spleen reinforcing stomach function regulating, Yiqi and vein recovery." Japan hanako materia medica ": peace soul determines soul.Mend five kinds of strain and seven kinds of impairment, all be deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle, separates cold and hot.

Side's solution of the present invention is: Radix Panacis Quinquefolii boosting qi and nourishing yin in side, clearing away heat and promoting production of body fluid, Rhizoma Polygonati Odorati nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst, maltose easing middle-JIAO and tonifying for deficiency, Arillus Longan invigorating the heart and spleen, nourishing blood to tranquillize the mind, Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, above Six-element is monarch drug altogether, due to the impact that patient is radiated, the each organ of health is all subject to damage in various degree, and monarch drug is started with from the five internal organs of health, and scholar supports the vital organs of the human body, boosting qi and nourishing yin, spleen invigorating mind calming, thus make patient break away from symptom, accelerate the improvement of patient, Rhizoma Alismatis clearing away heat-damp and promoting diuresis, Rhizoma Nelumbinis juice hemostasis dissipating blood stasis, Fructus Mume astringing to arrest diarrhea, Radix Trichosanthis clearing away heat and promoting production of body fluid, detumescence and apocenosis, Stigma Maydis inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting, Rhizoma Phragmitis clearing away heat and promoting production of body fluid, Rhizoma Imperatae cooling blood for hemostasis, Carapax Trionycis, Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, above a few taste is ministerial drug altogether, adds the efficacy of a drug of monarch drug on the one hand, also has removing heat from blood on the other hand, hemostasis, dissipating blood stasis, effect of eliminating carbuncle, can acute radiation sickness cause hemorrhage, ulcer, and change-session is dizzy, feel sick etc. symptom.Fructus Corni liver and kidney tonifying, Radix Adenophorae nourishing YIN and clearing away lung-heat, Radix Polygoni Multiflori enriching blood and promoting secretion of body fluid, removing toxicity for eliminating carbuncles, Colla Corii Asini nourishing blood YIN nourishing, Herba Dendrobii reinforcing stomach reg fluid, nourishing YIN and clearing away heat, Fructus Lycii, Herba Pyrolae nourishing the liver and kidney, Rhizoma Polygonati boosting qi and nourishing yin, Placenta Hominis the kidney warming mends essence, benefiting QI and nourishing blood, Rhizoma Anemarrhenae clearing away heat-fire, Semen Astragali Complanati temperature compensation Liver and kidney, above a few taste is adjuvant drug altogether, most liver and kidney tonifying, stomach reinforcing spleen invigorating, the kidney being the origin of congenital constitution, taste the foundation of acquired constitution, the health of patient fundamentally nursed one's health by medicine, thus reaches the object of elimination.Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, priming return through, for making medicine.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, has effect of boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, invigorating the heart and spleen, cooling blood for hemostasis, effectively can treat acute radiation sickness.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Panacis Quinquefolii 7-17 part, Rhizoma Polygonati Odorati 7-17 part, maltose 13-23 part, Arillus Longan 15-25 part, Rhizoma Atractylodis 10-20 part, Poria 10-20 part, Rhizoma Alismatis 10-20 part, Rhizoma Nelumbinis juice 15-25 part, Fructus Mume 19-29 part, Radix Trichosanthis 25-35 part, Stigma Maydis 25-35 part, Rhizoma Phragmitis 25-35 part, Rhizoma Imperatae 25-35 part, Carapax Trionycis 13-23 part, Carapax et Plastrum Testudinis 13-23 part, Fructus Corni 7-17 part, Radix Adenophorae 15-25 part, Radix Polygoni Multiflori 15-25 part, Colla Corii Asini 3-9 part, Herba Dendrobii 13-23 part, Fructus Lycii 15-25 part, Herba Pyrolae 10-20 part, Rhizoma Polygonati 15-25 part, Placenta Hominis 10-20 part, Rhizoma Anemarrhenae 7-17 part, Semen Astragali Complanati 13-23 part, Radix Glycyrrhizae 4-14 part.

Wherein be preferably: Radix Panacis Quinquefolii 12 parts, Rhizoma Polygonati Odorati 12 parts, maltose 18 parts, Arillus Longan 20 parts, Rhizoma Atractylodis 15 parts, 15 parts, Poria, Rhizoma Alismatis 15 parts, 20 parts, Rhizoma Nelumbinis juice, Fructus Mume 24 parts, Radix Trichosanthis 30 parts, Stigma Maydis 30 parts, Rhizoma Phragmitis 30 parts, Rhizoma Imperatae 30 parts, Carapax Trionycis 18 parts, Carapax et Plastrum Testudinis 18 parts, Fructus Corni 12 parts, Radix Adenophorae 20 parts, Radix Polygoni Multiflori 20 parts, 6 parts, Colla Corii Asini, Herba Dendrobii 18 parts, Fructus Lycii 20 parts, Herba Pyrolae 15 parts, Rhizoma Polygonati 20 parts, Placenta Hominis 15 parts, the Rhizoma Anemarrhenae 12 parts, Semen Astragali Complanati 18 parts, Radix Glycyrrhizae 9 parts.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations, as pill, powder, tablet, oral liquid etc.Such as these crude drug pulverize mix homogeneously can be made powder to take after mixing it with water; Can decocting be used, obtain filtrate after filtration, add antiseptic and make oral liquid; Also directly decoction can be taken if desired.

The preferred preparation method of the present invention is granule, and its preparation method is as follows:

Step one: by weight proportion of the present invention, first becomes medicated bag by Arillus Longan, Fructus Mume, Fructus Corni, Fructus Lycii, Semen Astragali Complanati bundle, is put in water and soaks 40-50 minute, filters, for subsequent use;

Step 2: by weight proportion of the present invention, by Poria, the air-dry pulverizing of Placenta Hominis, crosses 180 mesh sieves, for subsequent use;

Step 3: by weight proportion of the present invention, by Carapax Trionycis, Carapax et Plastrum Testudinis is suitably pulverized to put into after marmite adds step one immersion and is remained cold water, exceed the horizontal finger of powder 4 ~ 5, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, appropriate water is added in residue medicinal residues, add Radix Panacis Quinquefolii, Rhizoma Polygonati Odorati, Rhizoma Atractylodis, Radix Trichosanthis, Rhizoma Phragmitis, Rhizoma Imperatae, Radix Adenophorae, Radix Polygoni Multiflori, Rhizoma Polygonati, the Rhizoma Anemarrhenae is put into pot and is decocted 40-50 minute, add Rhizoma Alismatis afterwards, Herba Dendrobii, Herba Pyrolae, medicated bag in Radix Glycyrrhizae and step one, put into pot and continue decoction 30 minutes, finally add Rhizoma Nelumbinis juice and Stigma Maydis, decoct 10 minutes, filter, obtain filtrate, for subsequent use,

Step 4: twice filtrate in step 3 is merged, while hot maltose and Colla Corii Asini are put into hot soup and carry out molten, and by about concentration of liquid medicine to 80 DEG C time, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, then the fine powder mixing in step 2 is added in thick paste, stir, thick paste is dry, be ground into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 10g/ bag, every bag of granule containing crude drug 5g.

Medicine of the present invention has effect of boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, invigorating the heart and spleen, cooling blood for hemostasis, and curative effect is obvious, cheap, safe ready, side effect is little, according to clinical 160 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 85%, two the total effective rate course for the treatment of 95%.

Detailed description of the invention

Embodiment one, Radix Panacis Quinquefolii 7 parts, Rhizoma Polygonati Odorati 7 parts, maltose 13 parts, Arillus Longan 15 parts, Rhizoma Atractylodis 10 parts, 10 parts, Poria, Rhizoma Alismatis 10 parts, 15 parts, Rhizoma Nelumbinis juice, Fructus Mume 19 parts, Radix Trichosanthis 25 parts, Stigma Maydis 25 parts, Rhizoma Phragmitis 25 parts, Rhizoma Imperatae 25 parts, Carapax Trionycis 13 parts, Carapax et Plastrum Testudinis 13 parts, Fructus Corni 7 parts, Radix Adenophorae 15 parts, Radix Polygoni Multiflori 15 parts, 3 parts, Colla Corii Asini, Herba Dendrobii 13 parts, Fructus Lycii 15 parts, Herba Pyrolae 10 parts, Rhizoma Polygonati 15 parts, Placenta Hominis 10 parts, the Rhizoma Anemarrhenae 7 parts, Semen Astragali Complanati 13 parts, Radix Glycyrrhizae 4 parts.

Embodiment two, Radix Panacis Quinquefolii 12 parts, Rhizoma Polygonati Odorati 12 parts, maltose 18 parts, Arillus Longan 20 parts, Rhizoma Atractylodis 15 parts, 15 parts, Poria, Rhizoma Alismatis 15 parts, 20 parts, Rhizoma Nelumbinis juice, Fructus Mume 24 parts, Radix Trichosanthis 30 parts, Stigma Maydis 30 parts, Rhizoma Phragmitis 30 parts, Rhizoma Imperatae 30 parts, Carapax Trionycis 18 parts, Carapax et Plastrum Testudinis 18 parts, Fructus Corni 12 parts, Radix Adenophorae 20 parts, Radix Polygoni Multiflori 20 parts, 6 parts, Colla Corii Asini, Herba Dendrobii 18 parts, Fructus Lycii 20 parts, Herba Pyrolae 15 parts, Rhizoma Polygonati 20 parts, Placenta Hominis 15 parts, the Rhizoma Anemarrhenae 12 parts, Semen Astragali Complanati 18 parts, Radix Glycyrrhizae 9 parts.

Embodiment three, Radix Panacis Quinquefolii 17 parts, Rhizoma Polygonati Odorati 17 parts, maltose 23 parts, Arillus Longan 25 parts, Rhizoma Atractylodis 20 parts, 20 parts, Poria, Rhizoma Alismatis 20 parts, 25 parts, Rhizoma Nelumbinis juice, Fructus Mume 29 parts, Radix Trichosanthis 35 parts, Stigma Maydis 35 parts, Rhizoma Phragmitis 35 parts, Rhizoma Imperatae 35 parts, Carapax Trionycis 23 parts, Carapax et Plastrum Testudinis 23 parts, Fructus Corni 17 parts, Radix Adenophorae 25 parts, Radix Polygoni Multiflori 25 parts, 9 parts, Colla Corii Asini, Herba Dendrobii 23 parts, Fructus Lycii 25 parts, Herba Pyrolae 20 parts, Rhizoma Polygonati 25 parts, Placenta Hominis 20 parts, the Rhizoma Anemarrhenae 17 parts, Semen Astragali Complanati 23 parts, Radix Glycyrrhizae 14 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept out-patient 160 example for medical treatment, wherein male 86 example, women 74 example, M-F 1.16: 1,37 years old mean age, the course of disease time is not etc.

Two, Therapeutic Method:

According to Medications Example two of the present invention, and the granule that preferred preparation method is made, boiled water is taken after mixing it with water, every day 3 times, each one bag, within 20 days, is a course for the treatment of.

Three, efficacy assessment standard:

1, cure: acute radiation disease symptoms disappears completely, the phenomenons such as dizzy, nauseating, hemorrhage, ulcer disappear do not recurring completely;

2, take a turn for the better: acute radiation disease symptoms disappears substantially, and weather is normal;

3, do not heal: acute radiation disease symptoms is without any improvement.

Four, therapeutic outcome statistics

Have and above-mentionedly can to find out, Chinese medicine of the present invention has good clinical effectiveness in treatment acute radiation sickness, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.

Model case and curative effect:

Case one, patient Zhang, man, 41 years old, long-term in nuclear power station work, nearest appearance is felt sick, the baffled symptom such as hemorrhage, and there is the phenomenon of the long-term disunion of oral ulcer, remove examination in hospital, be diagnosed as acute radiation sickness, patient adopts made preparation in the embodiment of the present invention two, and selected preparation method, after taking treatment a period of time, the state of an illness is taken a turn for the better, being eased of uncomfortable phenomenon, acute radiation disease symptoms is eased, continue two courses for the treatment of of use, patient's readme health is good, remove examination in hospital, every treatment is all normal, recovery from illness.

Case two, patient Zhao, female, 60 years old, always in hospital radiological department work, occur recently suddenly feeling sick, agitation, anemia, hemorrhage existing, through examination in hospital, be diagnosed as acute radiation sickness, patient adopts made preparation in the embodiment of the present invention two, and selected preparation method, after taking treatment a period of time, the state of an illness is taken a turn for the better, and hemorrhage, Anemia is eased, continue to take a course for the treatment of, readme health takes a turn for the better, and indices recovers normal on inspection, recovery from illness.

Claims (4)

1. treat the Chinese medicine preparation of acute radiation sickness for one kind, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Panacis Quinquefolii 7-17 part, Rhizoma Polygonati Odorati 7-17 part, maltose 13-23 part, Arillus Longan 15-25 part, Rhizoma Atractylodis 10-20 part, Poria 10-20 part, Rhizoma Alismatis 10-20 part, Rhizoma Nelumbinis juice 15-25 part, Fructus Mume 19-29 part, Radix Trichosanthis 25-35 part, Stigma Maydis 25-35 part, Rhizoma Phragmitis 25-35 part, Rhizoma Imperatae 25-35 part, Carapax Trionycis 13-23 part, Carapax et Plastrum Testudinis 13-23 part, Fructus Corni 7-17 part, Radix Adenophorae 15-25 part, Radix Polygoni Multiflori 15-25 part, Colla Corii Asini 3-9 part, Herba Dendrobii 13-23 part, Fructus Lycii 15-25 part, Herba Pyrolae 10-20 part, Rhizoma Polygonati 15-25 part, Placenta Hominis 10-20 part, Rhizoma Anemarrhenae 7-17 part, Semen Astragali Complanati 13-23 part, Radix Glycyrrhizae 4-14 part.

2. the Chinese medicine preparation for the treatment of acute radiation sickness according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Panacis Quinquefolii 12 parts, Rhizoma Polygonati Odorati 12 parts, maltose 18 parts, Arillus Longan 20 parts, Rhizoma Atractylodis 15 parts, 15 parts, Poria, Rhizoma Alismatis 15 parts, 20 parts, Rhizoma Nelumbinis juice, Fructus Mume 24 parts, Radix Trichosanthis 30 parts, Stigma Maydis 30 parts, Rhizoma Phragmitis 30 parts, Rhizoma Imperatae 30 parts, Carapax Trionycis 18 parts, Carapax et Plastrum Testudinis 18 parts, Fructus Corni 12 parts, Radix Adenophorae 20 parts, Radix Polygoni Multiflori 20 parts, 6 parts, Colla Corii Asini, Herba Dendrobii 18 parts, Fructus Lycii 20 parts, Herba Pyrolae 15 parts, Rhizoma Polygonati 20 parts, Placenta Hominis 15 parts, the Rhizoma Anemarrhenae 12 parts, Semen Astragali Complanati 18 parts, Radix Glycyrrhizae 9 parts.

3. the Chinese medicine preparation for the treatment of acute radiation sickness according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is granule.

4. treat a preparation method for the Chinese medicine preparation of acute radiation sickness, it is characterized in that, preparation method is as follows: step one: by weight proportion of the present invention, first Arillus Longan, Fructus Mume, Fructus Corni, Fructus Lycii, Semen Astragali Complanati bundle are become medicated bag, be put in water and soak 40-50 minute, filter, for subsequent use, step 2: by weight proportion of the present invention, by Poria, the air-dry pulverizing of Placenta Hominis, crosses 180 mesh sieves, for subsequent use, step 3: by weight proportion of the present invention, by Carapax Trionycis, Carapax et Plastrum Testudinis is suitably pulverized to put into after marmite adds step one immersion and is remained cold water, exceed the horizontal finger of powder 4 ~ 5, after being fried boiling with high heat, again with 20 ~ 30 minutes at a simmer, filter, obtain filtrate, appropriate water is added in residue medicinal residues, add Radix Panacis Quinquefolii, Rhizoma Polygonati Odorati, Rhizoma Atractylodis, Radix Trichosanthis, Rhizoma Phragmitis, Rhizoma Imperatae, Radix Adenophorae, Radix Polygoni Multiflori, Rhizoma Polygonati, the Rhizoma Anemarrhenae is put into pot and is decocted 40-50 minute, add Rhizoma Alismatis afterwards, Herba Dendrobii, Herba Pyrolae, medicated bag in Radix Glycyrrhizae and step one, put into pot and continue decoction 30 minutes, finally add Rhizoma Nelumbinis juice and Stigma Maydis, decoct 10 minutes, filter, obtain filtrate, for subsequent use, step 4: twice filtrate in step 3 is merged, while hot maltose and Colla Corii Asini are put into hot soup and carry out molten, and by about concentration of liquid medicine to 80 DEG C time, add 75% ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, the thick paste of relative density 1.13 ~ 1.20 under 60 DEG C of environment, then the fine powder mixing in step 2 is added in thick paste, stir, thick paste is dry, be ground into fine powder, add appropriate Icing Sugar as diluent, ethanol as wetting agent and microcrystalline Cellulose as disintegrating agent, adopt dry granulation, make 10g/ bag, every bag of granule containing crude drug 5g.