CN105267940A - Traditional Chinese medicine composition for preventing and treating gastric ulcer and preparation method thereof - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for preventing and treating gastric ulcer. The traditional Chinese medicine composition comprises the components of Mongolian dandelion herb, licorice root, notoginseng, honeysuckle flower, sessileflower acanthopanax bark, Chinese dates, wolfberry fruit and spina date seeds and the like. Compared with the prior art, the traditional Chinese medicine composition provided by the invention has the advantages of being good in curative effect, low in cost and small in limitation, having no adverse reaction and the like. Active ingredients of all raw material of the traditional Chinese medicine composition influence each other to achieve a synergistic effect, so that the traditional Chinese medicine composition has a very good curative effect on gastric ulcer patients. Moreover, the preparation method of the traditional Chinese medicine composition is simple, is strict in compatibility and mild in temperament, is safe, does not have side effects, is low in cost, is suitable for taking by all kinds of people, and is convenient for large-area popularization and application clinically.

Description

Chinese medicine composition of a kind of prevention and therapy gastric ulcer and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to Chinese medicine composition of a kind of prevention and therapy gastric ulcer and preparation method thereof.

Background technology

Peptic Ulcers or peptic ulcer are a kind of common digestive tract disease, esophagus, stomach or duodenum can be betided, also can betide near stomach-intestinal anastomosis mouth or containing in the Meckel diverticulum of gastric mucosa, because gastric ulcer and duodenal ulcer the most common, therefore general so-called peptic ulcer refers to gastric ulcer and duodenal ulcer.Why it is referred to as peptic ulcer, because previously think that gastric ulcer and duodenal ulcer are because gastric acid and pepsin formed mucosa autodigestion, in fact gastric acid and pepsin are the one of the main reasons of ulcer, also have other reasons to form peptic ulcer.Because the cause of disease of gastric ulcer and duodenal ulcer and clinical symptoms have many similarities, being sometimes difficult to differentiation is gastric ulcer or duodenal ulcer, is therefore often diagnosed as peptic ulcer, or taste-blindness rate.If the clear and definite ulcer of energy is at stomach or duodenum, that just can directly be diagnosed as gastric ulcer or duodenal ulcer.

In gastral cavity, gastric acid and pepsin are digestion materials important in gastric juice.Gastric acid is highly acid material, has stronger aggressivity; Pepsin has the effect of aminosal, the protein on coat of the stomach can be destroyed, but, under the existence of these factors of erosion, gastrointestinal tract still can be resisted and maintain integrity and the function of self of mucosa, and it is mainly because Grastiodudenal mucosa also has series of defence and repair mechanism.Gastric acid and pepsic harmful aggressive are referred to as damage mechanisms by us, and the defence had by gastrointestinal tract self and repair mechanism are referred to as protection mechanism.Think that the protection mechanism of the gastroduodenal mucosa of normal person is enough to opposing gastric acid and pepsic erosion at present.But gastric acid just may occur certain link compromised in protection mechanism when some factor and protease corrodes self mucosa and causes the formation of ulcer.When excessive gastric acid secretion also may cause ulcer to occur considerably beyond the defence of mucosa and repair.In recent years research shows, helicobacter pylori and NSAID (non-steroidal anti-inflammatory drug) be the infringement gastrointestinal protection mechanism most commonly encountered diseases that causes ulcer to be fallen ill because of, gastric acid plays a crucial role in ulcer.In addition, medicine, stress, hormone also can cause the generation of ulcer, and various psychological factor and bad dietary life habits can the appearance of induced ulcer.

Gastric ulcer symptom is not often true to type and can shows as upper abdominal pain and epigastric discomfort etc.The overwhelming majority people can there is various dyspeptic symptom, but have also without any symptom, until develop complications.Its common complication mainly contains hemorrhage, perforation, pyloric obstruction (Pyloricobstruction), canceration.Common gastrointestinal symptom and General Symptoms mainly contain burn feeling, Nausea and vomiting, poor appetite etc. after belch, acid regurgitation, big belly, breastbone.After acid regurgitation and breastbone, burn feeling is due to cardiochalasia, and Nausea and vomiting many reflections ulcer may point out ulcer to be in active stage.Frequent vomiting dyspepsia, prompting pyloric obstruction.Some patients has the autonomic nervous dysfunction such as insomnia, hyperhidrosis symptom.

The general doctor trained in Western medicine of existing treatment means with in and gastric acid be major-minor to promote the rehabilitation of stomach film, but known to practice, through said medicine treatment situation majority be slow down the state of an illness, control develop into main purpose, thoroughly can not cure Peptic Ulcers, thus sufferer often recurs; When treating gastrointestinal disease, Chinese patent medicine class gastrointestinal medication comparatively chemical classes gastrointestinal medication, has that its side effect is little, an advantage of long-term taking no dependence etc. and be subject to the welcome of extensive patients.But the Chinese patent medicine curative effect of more existing treatment gastropathy is unsatisfactory, and price is faced upward expensive, makes patients with gastric disease obstinate, can bring the misery of chronicity to patient.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine composition of prevention and therapy gastric ulcer, to gastric ulcer, there is significant curative effect.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition of prevention and therapy gastric ulcer, is made up of following component:

Herba Taraxaci 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Notoginseng 1-30 part, Flos Lonicerae 1-30 part, Cortex Acanthopancis 1-30 part, Olibanum 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Dioscorea zingiberensis 1-30 part, Pericarpium Zanthoxyli 1-30 part, Bulbus Lilii 1-30 part, Poria 1-30 part, Rhizoma Pinelliae 1-30 part, Rhizoma Coptidis 1-30 part, Radix Codonopsis 1-30 part, Herba Leonuri 1-30 part, Fructus Aurantii Immaturus 1-30 part, Radix Pulsatillae 1-30 part, Radix Astragali 1-30 part, Fructus Jujubae 1-30 part, Radix Platycodonis 1-30 part, Endothelium Corneum Gigeriae Galli 1-30 part, Semen Ziziphi Spinosae 1-30 part, Semen Plantaginis 1-30 part, Radix Sanguisorbae 1-30 part, Sanguis Draxonis 1-30 part, Fructus Trichosanthis 1-30 part, Rhizoma Acori Graminei 1-30 part, Fructus Evodiae 1-30 part, Radix Rehmanniae 1-30 part, Semen Myristicae 1-30 part, Semen Raphani 1-30 part.

The Chinese medicine composition of described treatment gastric ulcer, in Chinese medicine preparation described in it, the parts by weight of various crude drug can be preferably: Herba Taraxaci 1-20 part, Radix Glycyrrhizae 1-20 part, Radix Notoginseng 1-10 part, Flos Lonicerae 1-30 part, Cortex Acanthopancis 1-30 part, Olibanum 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Dioscorea zingiberensis 1-30 part, Pericarpium Zanthoxyli 1-30 part, Bulbus Lilii 1-30 part, Poria 1-10 part, Rhizoma Pinelliae 1-30 part, Rhizoma Coptidis 1-15 part, Radix Codonopsis 1-10 part, Herba Leonuri 1-30 part, Fructus Aurantii Immaturus 1-30 part, Radix Pulsatillae 1-30 part, Radix Astragali 1-30 part, Fructus Jujubae 1-30 part, Radix Platycodonis 1-30 part, Endothelium Corneum Gigeriae Galli 1-20 part, Semen Ziziphi Spinosae 1-30 part, Semen Plantaginis 1-20 part, Radix Sanguisorbae 1-30 part, Sanguis Draxonis 1-30 part, Fructus Trichosanthis 1-30 part, Rhizoma Acori Graminei 1-30 part, Fructus Evodiae 1-30 part, Radix Rehmanniae 1-30 part, Semen Myristicae 1-20 part, Semen Raphani 1-20 part.

The Chinese medicine composition of described treatment gastric ulcer, in Chinese medicine preparation described in it, the parts by weight of various crude drug can also be preferably: Herba Taraxaci 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Notoginseng 1-10 part, Flos Lonicerae 5-20 part, Cortex Acanthopancis 1-20 part, Olibanum 1-20 part, Radix Bupleuri 2-20 part, Fructus Lycii 1-20 part, Dioscorea zingiberensis 2-30 part, Pericarpium Zanthoxyli 3-30 part, Bulbus Lilii 1-30 part, Poria 1-10 part, Rhizoma Pinelliae 2-10 part, Rhizoma Coptidis 2-15 part, Radix Codonopsis 1-10 part, Herba Leonuri 1-30 part, Fructus Aurantii Immaturus 2-10 part, Radix Pulsatillae 1-10 part, Radix Astragali 1-20 part, Fructus Jujubae 5-30 part, Radix Platycodonis 5-30 part, Endothelium Corneum Gigeriae Galli 2-10 part, Semen Ziziphi Spinosae 2-10 part, Semen Plantaginis 1-20 part, Radix Sanguisorbae 1-30 part, Sanguis Draxonis 1-30 part, Fructus Trichosanthis 1-10 part, Rhizoma Acori Graminei 1-30 part, Fructus Evodiae 2-20 part, Radix Rehmanniae 1-30 part, Semen Myristicae 1-20 part, Semen Raphani 5-20 part.

The Chinese medicine composition of described treatment gastric ulcer, the dosage form of Chinese medicine preparation described in it can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine composition for the treatment of gastric ulcer, and when the dosage form of described Chinese medicine composition is capsule, its preparation method comprises the following steps:

A, super micron mill are adopted to be ground into micropowders Herba Taraxaci, Radix Glycyrrhizae, Radix Notoginseng, Flos Lonicerae, Cortex Acanthopancis, Fructus Jujubae, Fructus Lycii, Semen Ziziphi Spinosae eight kinds of crude drug;

B, Rhizoma Acori Graminei, Olibanum steaming process extract volatile oil, become crystalline powder;

C, all the other crude drug add the ethanol of 1-5 times amount, 50-100 DEG C of alcoholization 100 minutes, then add the water of 1-5 times amount, 80 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off, in the high temperature resistant high rejection rolling NF membrane of 300KDalton, is isolated the large particulate matter in filtrate and supernatant, supernatant concentration, is obtained mastic, dry mastic, pulverize to obtain powder;

D, the canned capsule of medicated powder that above-mentioned steps is collected.

In described step a, put into by described crude drug after pulverizer is pulverized and cross 200 order dusting covers, the enable fine powder amount by 200 mesh sieves is reaching 50%, collects by the raw material fine powder of 200 mesh sieves for subsequent use.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine composition for the treatment of gastric ulcer, and the honey that the dosage form of described preparation is refines pill, and its preparation method comprises:

A, first described crude drug Herba Taraxaci, Radix Glycyrrhizae, Radix Notoginseng, Flos Lonicerae, Cortex Acanthopancis, Fructus Jujubae, Fructus Lycii, spiny jujuba seed powder are broken into coarse powder and sieve, fine powder is for subsequent use; The coarse grain that do not sieve put into multi-function extractor add ethanol extraction 2 times extractum;

B, surplus stock medicine is added ethanol extraction 2 times;

C, twice filtrate is merged to obtain extractum, mixes with the extractum that step a obtains, put into 80 DEG C, baking oven dry after cooling, grind to form fine powder;

The thin medicated powder that d, collection above-mentioned steps obtain is called in Mel and is made honey refining pill.

In described step a, first crude drug Herba Taraxaci, Radix Glycyrrhizae, Radix Notoginseng, Flos Lonicerae, Cortex Acanthopancis, Fructus Jujubae, Fructus Lycii, spiny jujuba seed powder are broken into coarse powder and cross sieved 80 mesh sieves, the enable fine powder amount by 80 mesh sieves is reaching 40%, collects and obtains fine powder a by the fine powder of 80 mesh sieves; Again the coarse powder not by 80 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 3-5 times amount ethanol extraction 2 hours, and second time adds 1-2 times amount ethanol extraction 2 hours, merges twice decocting liquid, filters to get filtrate; Decompression recycling ethanol, becomes extractum shape.

In described step b, surplus stock medicine is added 80% soak with ethanol 2 hours of 5-10 times amount, extract 2 times; Heating extraction 2 hours, is concentrated into filtrate paste, when filtrate reduced in volume relative density is 80 DEG C 1.35 filtrate, decompression recycling ethanol, becomes extractum shape.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine composition for the treatment of gastric ulcer, and the dosage form of described Chinese medicine preparation is oral solutions, and its preparation process comprises:

A, get crude drug and put into water and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

The Chinese medicine composition of described treatment gastric ulcer, the using method of Chinese medicine described in it is, the present invention decocts decoction when taking, and every day 1 dose, decocting takes at twice, and every 10 days is a course for the treatment of; When capsule, tablet, pill use, each 1,1 or 1 ball, every day three times, every 7 days is a course for the treatment of.

The present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.The each raw material active ingredient of the present invention influences each other, synergism, has good therapeutic effect to patients w ith peptic ulcer disease.And Chinese medicinal preparation method of the present invention is simple, compatibility is rigorous, mild in medicine property and, safety has no side effect, with low cost, suitable all kinds of crowd takes, and is convenient to large scale application clinically.

Detailed description of the invention

Peptic Ulcers belong to motherland's medical science " gastric abscess ", " stomachache due to hyperactive liver-QI attacking the stomach ", " pained ", " acid regurgitation " waits category.Among the peoplely to be called more " epigastric pain ", " peratodynia ", " stomachache ", " hungry consumptive disease " etc. of satisfying.Peptic Ulcers with the rhythmicity upper abdominal pain of recurrent exerbation for clinical characters, often with heating installation, return acid, the sensation such as scorching hot, noisy, even also have Nausea and vomiting, hematemesis, have blood in stool.Circle, oval chronic ulcer is had in gastrointestinal local.

Herba Taraxaci: nature and flavor: bitter sweet, cold.Tang Materia Medica: sweet in the mouth is flat, nontoxic.Li Gao: micro-hardship, cold." book on Chinese herbal medicine is stated ": sweet, puts down and is slightly cold.Guangzhou army " conventional Chinese herbal medicine handbook ": bitter sweet, cold.Gui Jing: enter liver, stomach warp.Li Gao: meridian of Foot-SHAO YIN." Amplification on Materia Medica addendum ": enter bright, the Taiyin channels of sun.Function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.To low-priced and have large merit, do not know to use it by means of common people.The fire that sun is bright, often to setting a prairie fire, with Baihu Tang with pathogenic fire purging, injure one's stomach gas rather.Fire in lid stomach is contained, because stomach sergeant declines also, and pathogenic fire purging and soil more declines.Therefore with from brave soup to rush down stomach-fire, be the extremely suitable of a period of time, and can not rely on for also prolonged.Herba Taraxaci also rushes down the medicine of stomach-fire, but its gas is very flat, can pathogenic fire purging, does not damage soil again, can grow clothes clothes and not hindering for a long time.The fire person that all systems sun is bright, all agent can take it greatly, fire moves back and gastric qi is spontaneous.But the power of its pathogenic fire purging is very micro-, must be multiplex, one or two, few also five, six money, begin loose evil auxiliary positive ear.Or ask, Herba Taraxaci pathogenic fire purging that the fire of each warp failed to see by the fire that antidiarrheal sun is bright, also can disappear to the greatest extent? say, the strongest person of fire, without crossing the bright flame of sun, the bright fire of sun falls, and each through ember without disappearing not to the utmost.Though the medicine of the non-each warp of Herba Taraxaci, and the fire of each warp, see Herba Taraxaci and most volt, namely meaning Herba Taraxaci can disappear the fire of each warp, also without can not be also.Or ask that Herba Taraxaci and Flos Lonicerae are both the thing of eliminating carbuncle infections, two things are who victory after all? husband's Herba Taraxaci stops into bright, lunar two warps of sun, and Flos Lonicerae is not then without through entering, and Herba Taraxaci can not be same as function also with Flos Lonicerae.Right Flos Lonicerae obtains Herba Taraxaci and its merit is larger.

Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Raw with cool and pathogenic fire purging, main loose pathogenic factor in the exterior, subduing inflammation, sore-throat relieving pain, separates hundred poison of drug, except stomach accumulated heat, goes urinary catheter pain, and the power of this sweet cool heat extraction also.Process the invigorating middle warmer by temperature, main insufficiency of the spleen cunning is rushed down, and insufficiency of stomach is thirsty, and cold and heat are coughed, and breathe hard sleepy, forced labour is deficient, and this sweet temperature helps the merit of spleen also.But rich and too sweet, unsuitable multiplex in tonic, probably love diaphragm does not think food yet."

Radix Notoginseng: nature and flavor: sweet micro-hardship, temperature.1. " detailed outline ": " sweet micro-hardship, temperature, nontoxic." 2. " book on Chinese herbal medicine converges and says ": " sweet and slightly bitter taste, property is put down, nontoxic." return through: enter liver, stomach, large intestine channel.1. " book on Chinese herbal medicine converges and says ": " enter bright, the JUE YIN meridian of sun." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, stomach, double enter the heart, large intestine." 3. " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.1. " detailed outline ": " hemostasis, loose blood, analgesic therapy.Gold sword arrow wound, fall and flutter flogging injury, blood goes out more than person, chews rotten painting, or for mixing it in end, namely its blood stop.Also main haematemesis, epistaxis, hematochezia, dysentery, metrorrhagia, incessant menorrhea, puerperal stagnant blood not under, blood transport, blood pain, Akamu, carbuncle, tiger stings, all diseases of snakebite." 2. " jade seizes medicine solution ": " and battalion's hemostasis, clots absorbing of promoting blood circulation, clots absorbing blood and hold back fresh blood.All puerperal, menstrual period, traumatic injury, carbuncle, all blood stasis are all broken; Allly tell nosebleed, metrorrhagia, knife injury, arrow penetrate, all fresh blood all stop."

Flos Lonicerae: nature and flavor: sweet, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, bitter in the mouth." 2. " book on Chinese herbal medicine just ": " sweet in the mouth, gas is put down, its cold nature." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " must join book on Chinese herbal medicine ": " enters bright, the Taiyin channels of foot sun." function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.

Cortex Acanthopancis: nature and flavor: pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " be bitter, is slightly cold, nontoxic." 3. " property of medicine opinion ": " is slightly poisonous." 4. " medical center bun is wanted ": " is bitter micro-pungent, cold." 5. " Traditional Chinese Medicine in Sichuan will ": " is warm in nature, and sweet in the mouth is nontoxic." return through: enter liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter lung, kidney two warp." 2. " Bencao Jingshu ": " enters few cloudy, the JUE YIN meridian of foot." function cures mainly: wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt.Control anemofrigid-damp arthralgia, muscles and bones contraction is anxious, lumbago, sexual impotence, flaccidity of the lower limbs, children's's walking retardation in children, edema, beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.

Olibanum: nature and flavor: arduous, temperature.1. " not Lu ": " tepor." 2. " Japan hanako materia medica ": " acrid in the mouth, heat, micro-poison." 3. Li Gao: " bitter in the mouth is pungent, heat." return through: enter the heart, liver, spleen channel.1. Zhu Zhenheng: " enter meridian of Hand-SHAO YIN.It is few cloudy that " 2. " Bencao Jingshu ": " enters lunar, the hands of foot, double enter meridian of Foot-JUE YIN." function cures mainly: regulating qi and activating blood, and analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.

Radix Bupleuri: nature and flavor: bitter, cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be slightly cold, nontoxic." 3. " Japan hanako materia medica ": " sweet in the mouth." return through: enter liver, gallbladder meridian.1. " pearl sac ": " enter foot-shaoyang gallbladder, liver meridian, hands lacks sun three Jiao, hands faints cloudy percardium." 2. " book on Chinese herbal medicine is new again ": " enters the heart, liver, spleen three warp." function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.

Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.

Dioscorea zingiberensis: nature and flavor: arduous, temperature.1. Tang Materia Medica: " acrid in the mouth is bitter, Great Cold, nontoxic." 2. supplement to the Herbal: " acrid in the mouth, temperature, nontoxic." 3. Li Gao: " bitter but sweet flavor is pungent, Great Cold, nontoxic." 4. " Dong-eui-bo-gam ": " is hot in nature, and acrid in the mouth is bitter, nontoxic." return through: enter spleen, Liver Channel.1. " detailed outline ": " enter the heart, spleen." 2. " Thunder God concocts property of medicine solution ": " enters the heart, lung two warp." 3. " Bencao Jingshu ": " enters lunar, the moon of fainting of foot." function cures mainly: removing blood stasis, and circulation of qi promoting is stimulated the menstrual flow, pain relieving.Control trusted subordinate's feeling of fullness distending pain, brachialgia, lump in the abdomen, women's blood stasis amenorrhea, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.

Pericarpium Zanthoxyli: nature and flavor: pungent, temperature, poisonous.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " raw temperature, heat is cold, poisonous." " is too hot, poisonous." 3. " property of medicine opinion ": " bitter in the mouth is pungent, slightly poisonous." return through: enter spleen, lung, kidney channel.1. " detailed outline ": " hands, foot are lunar, right kidney gate of vitality edema caused by disorder of QI." 2. " Bencao Jingshu ": " starts with, foot lunar, double enter meridian of Hand-JUE YIN." 3. " book on Chinese herbal medicine is newly organized ": " enters the heart, spleen channel." 4. " Changsha medicine solution ": " enters stomach of foot Yang Ming, liver meridian, kidney meridian, spleen of Foot-Taiyin." function cures mainly: warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, separates fish raw meat poison.Control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough with dyspnea, anemofrigid-damp arthralgia, has loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.

Bulbus Lilii: nature and flavor: sweet micro-hardship, flat.1. " herbal classic): " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. herbal for Relief of Famines: " sweet in the mouth is pungent, flat." 4. " Changsha medicine solution ": " sweet and slightly bitter taste, is slightly cold." return through: enter the heart, lung meridian.1. " Thunder God process of preparing Chinese medicine property of medicine solution " > Thunder God concocts property of medicine solution ": " enter cardiopulmonary, large and small intestinal four warp.It is lunar that " 2. " book on Chinese herbal medicine converge with speech ": " enters brothers, and brothers faint the moon, brothers' Yangming Channel." 3. " medicineization justice ": " enters lung, the heart, gallbladder three warp." function cures mainly: nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control lung expense chronic cough, cough and spit expectorant blood; After calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells; Beriberi edema.(1) nourishing the lung to arrest cough: for cough, the spitting of blood of the dryness of the lung or the deficiency of YIN, often join Bulbus Fritillariae Cirrhosae.(2) clearing away heart-fire for tranquillization:, restlessness of asrhenia type and insomnia, staring spells unclear for waste heat after febrile disease, often joins Radix Rehmanniae

Poria: nature and flavor: sweet light is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.1. Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters bladder, kidney, lung." 3. " Thunder God concocts property of medicine solution ": " enters lung, spleen, small intestinal three warp.It is few cloudy that " 4. " Bencao Jingshu ": " enters brothers, the hands sun, lunar, the Yangming Channel of foot." function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.

The Rhizoma Pinelliae: nature and flavor: pungent, temperature, poisonous.1. " herbal classic ": " pungent, flat." 2. " not Lu ": " be raw to be slightly cold, and ripe temperature is poisonous." 3. " property of medicine opinion ": " is very toxic." 4. " Japan hanako materia medica ": " acrid in the mouth." 5. (medicine origin ": " " curing mainly secret wanting " cloud, warm in nature, acrid in the mouth is bitter." return through: enter spleen, stomach warp.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness.Outer subduing inflammation.

Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Radix Codonopsis: nature and flavor: sweet is flat.Gui Jing: return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding." return through: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Fructus Aurantii Immaturus: nature and flavor: bitter, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " WU Pu Bencao ": " Thunder God: acid is nontoxic.Lee is when it: Great Cold." 3. " not Lu ": " acid, is slightly cold, nontoxic." 4. " property of medicine opinion ": " bitter in the mouth is pungent." return through: enter spleen, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter the heart, spleen two warp." 2. " Bencao Jingshu ": " enters bright, the Taiyin channels of foot sun." 3. " book on Chinese herbal medicine is new again ": " enters liver, spleen two warp." function cures mainly: dispelling the stagnated QI, and loose painful abdominal mass, rushes down expectorant, removing food stagnancy.Control distension and fullness of the chest and abdomen, the thoracic obstruction, painful abdominal mass pain, accumulation of phlegm in the hypochondrium, edema, food stagnation, constipation, gastroptosis, uterine prolapse, proctoptosis.

The Radix Pulsatillae: nature and flavor: bitter, cold.1. " herbal classic ": " bitter in the mouth, temperature, nontoxic." 2. " not Lu ": " be poisonous." 3. " property of medicine opinion ": " sweet-bitter flavor, slightly poisonous." 4. Li Gao: " bitter in the mouth, cold in nature." return through: enter large intestine, liver, stomach warp.Function cures mainly: clearing away heat and cooling blood, removing toxic substances.Control toxic-heat and blood stasis, pyrexial malaria cold and heat, epistaxis, internal hemorrhoid with bleeding.

The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Fructus Jujubae: nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Bark: antiinflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, metrorrhagia; Traumatic hemorrhage is controlled in external.Root: circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, redly to collapse, leucorrhea.

Radix Platycodonis: nature and flavor: toil is flat.1. " herbal classic ": " pungent, tepor." 2. " not Lu ": " be bitter, slightly poisonous." 3. " property of medicine opinion ": " is bitter, flat, nontoxic." return through: enter lung, stomach warp.1. Materia Medica of Decoction: " enter the few the moon of foot, hands is lunar." 2. " product remittance essence is wanted ": " row meridian of Foot-TAI YIN." 3. " Bencao Jingshu ": " starts with lunar, few cloudy, double enter the stomach channel of foot-Yang-ming." function cures mainly: open lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.

Endothelium Corneum Gigeriae Galli: nature and flavor: sweet is flat.1. " not Lu ": " be slightly cold." 2. " Japan hanako materia medica ": " puts down, nontoxic." 3. essentials of Matea Medica: " is sweet, and flat, property is puckery." return through: enter spleen, stomach warp.1. " Bencao Jingshu ": " large intestine, bladder two warp." 2. " book on Chinese herbal medicine is new again ": " enters spleen, stomach two warp." function cures mainly: removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.

Semen Ziziphi Spinosae: nature and flavor: sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." return through: enter the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." function cures mainly: nourishing the liver, and mind calming is calmed the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.

Semen Plantaginis: nature and flavor: sweet, cold.1. " herbal classic ": " sweet in the mouth, cold." 2. " not Lu ": " be salty, nontoxic." 3. " property of medicine opinion ": " is sweet, flat." 4. " medicineization justice ": " is lightly seasoned, and property is put down." return through: enter kidney, urinary bladder channel.1. " book on Chinese herbal medicine covers bamboo fish trap ": " enter bladder." 2. " Thunder God concocts property of medicine solution ": " enters liver, bladder, small intestinal three warp." 3. " Bencao Jingshu ": " enters kidney, liver, bladder three warp." function cures mainly: diuretic, heat clearing away, tomorrow, eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.

Radix Sanguisorbae: nature and flavor: picric acid, cold.1. " herbal classic ": " bitter in the mouth is slightly cold." 2. " not Lu ": " sweet acid, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is pained, temperature." return through: enter liver, large intestine channel.1. " Thunder God concocts property of medicine solution ": " enter large intestine, liver two warp." 2. " Bencao Jingshu ": " enters sufficient the moon of fainting, few cloudy, hands, Foot yangming Channel." 3. " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: blood on removing heat from blood, heat-clearing and toxic substances removing.Control haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.

Sanguis Draxonis: nature and flavor: Gan Xian is flat.1. Lei Gong's Treatise on Preparation and Broiling of Materia Medica: " taste is micro-salty sweet." 2. Tang Materia Medica: " sweet-salty is flat, slightly poisonous." 3. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid in the mouth is salty, and gas is put down, slightly poisonous." return through: enter the heart, Liver Channel.1. " detailed outline ": " brothers faint the moon." 2. " Bencao Jingshu ": " enters sufficient the moon of fainting, meridian of Hand-SHAO YIN." 3. " book on Chinese herbal medicine is newly organized ": " enters kidney." function cures mainly: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Control traumatic injury to lose, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.

Fructus Trichosanthis: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

Rhizoma Acori Graminei: nature and flavor: pungent, bitter, temperature.Gui Jing: GUIXIN, stomach warp.Function cures mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.

Fructus Evodiae: nature and flavor: pungent, bitter, heat; Slightly poisonous.Gui Jing: return liver, spleen, stomach, kidney channel.Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.

The Radix Rehmanniae: bitter but sweet flavor, gas is trembled with fear, and sink also, the moon also.Start with few the moon and hands lunar.The fire of cool women's head-ornaments, the heat of lung heat clearing liver, also monarch drug also.Its merit is specially in cooling blood for hemostasis, and kind treatment incised wound again, antiabortive gas, stimulates the menstrual flow, and leak-stopping collapses, and all has siddhi.But cold in nature, the cold person of taste is unsuitable multiplex.Husband's Radix Rehmanniae is kind removing heat from blood both, the absurd row of warm blood, or spits blood or epistaxis or hematochezia, and that should use is monarch, and adds Herba Schizonepetae with Gui Qijing, adds Radix Notoginseng Mo Yizhiqi road, and not removing of what heat and blood is more than again.But this taste can be multiplex and can not frequently use, can temporary and can not for a long time with also.Come also when blood, its gesture is very anxious, haves no alternative but reuse the Radix Rehmanniae, stops blooding with removing heat from blood.If blood one only, namely should use the agent of temperature compensation instead, improperly still to enter again also with the Radix Rehmanniae.Moderns do not know its event, and the god of frightened Radix Rehmanniae hemostasis, be considered as miraculous cure, everyday decoction, then taste are too cool for a long time, must to having loose bowels, and vigour is tried out, and blood heavily comes.Not realizing the Radix Rehmanniae uses many, and the anti-Radix Rehmanniae of doubting, with few, still more enters, and has increasing its point two, the person of realizing till death and not, also sad also husband.

Semen Myristicae: nature and flavor: pungent, temperature.1. " property of medicine opinion ": " bitter in the mouth is pungent." 2. " Haiyao Bencao, Oversea Materia Medica ": " acrid in the mouth, temperature, nontoxic." 3. " book on Chinese herbal medicine just ": " bitter in the mouth is pungent and puckery, warm in nature." return through: enter lung, large intestine channel.1. Materia Medica of Decoction: " enter meridian of Hand-YANG MING." 2. " Thunder God concocts property of medicine solution ": " enters lung, stomach two warp." 3. " Bencao Jingshu ": " enters foot, and too yin, yang is bright; The bright large intestine of hands sun." function cures mainly: warming middle-JIAO, and the therapeutic method to keep the adverse QI flowing downwards helps digestion, Gu intestinal.Control trusted subordinate's distending pain, diarrhea of deficiency type cold-dysentery, vomiting, dyspepsia does not disappear.

Semen Raphani: nature and flavor: Xin Gan, flat.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature, acrid in the mouth." 2. " detailed outline ": " Xin Gan is flat, nontoxic." 3. " beautiful Chinese catalpa medicine solution ": " is pungent, heat." 4. " Records of Tradition Chinese and Western Medicine in Combination ": " life taste is micro-pungent, temper; Fry with warm in nature." return through: enter lung, stomach warp.Function cures mainly: therapeutic method to keep the adverse QI flowing downwards Dingchuan, eliminates indigestion and phlegm.Control cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, heavy after dysentery.

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

A, super micron mill are adopted to be ground into micropowders Herba Taraxaci 5 parts, 5 parts, Radix Glycyrrhizae, Radix Notoginseng 1 part, Flos Lonicerae 5 parts, Cortex Acanthopancis 1 part, 5 parts, Fructus Jujubae, Fructus Lycii 1 part, Semen Ziziphi Spinosae 2 parts of eight kinds of crude drug;

B, Rhizoma Acori Graminei 1 part, Olibanum 1 part extract volatile oil with steaming process, become crystalline powder;

C, by Radix Bupleuri 2 parts, Dioscorea zingiberensis 2 parts, 3 parts, Pericarpium Zanthoxyli, Bulbus Lilii 1-part, 1 part, Poria, the Rhizoma Pinelliae 2 parts, Rhizoma Coptidis 2 parts, Radix Codonopsis 1 part, Herba Leonuri 1 part, Fructus Aurantii Immaturus 2 parts, the Radix Pulsatillae 1 part, the Radix Astragali 1 part, Radix Platycodonis 5 parts, Endothelium Corneum Gigeriae Galli 2 parts, Semen Plantaginis 1 part, Radix Sanguisorbae 1 part, Sanguis Draxonis 1 part, Fructus Trichosanthis 1 part, Fructus Evodiae 2 parts, 1 part, the Radix Rehmanniae, Semen Myristicae 1 part, Semen Raphani 5 parts of crude drug add the ethanol of 1-5 times amount, 50-100 DEG C of alcoholization 100 minutes, add the water of 1-5 times amount again, 80 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, the Chinese medicine residue filtered repeats above extraction step, merge twice filtrate, with aperture at 1000um, molecular cut off, in the high temperature resistant high rejection rolling NF membrane of 300KDalton, is isolated the large particulate matter in filtrate and supernatant, supernatant concentration, is obtained mastic, dry mastic, pulverize to obtain powder,

D, the canned capsule of medicated powder that above-mentioned steps is collected.

Embodiment 2

A, first crude drug Herba Taraxaci 5 parts, 5 parts, Radix Glycyrrhizae, Radix Notoginseng 1 part, Flos Lonicerae 5 parts, Cortex Acanthopancis 1 part, 5 parts, Fructus Jujubae, Fructus Lycii 1 part, Semen Ziziphi Spinosae 2 parts are ground into coarse powder and cross sieved 80 mesh sieves, the enable fine powder amount by 80 mesh sieves is reaching 40%, collect and obtain fine powder a by the fine powder of 80 mesh sieves, the coarse grain that do not sieve drops into multi-function extractor and extracts twice, first time adds 3-5 times amount ethanol extraction 2 hours, second time adds 1-2 times amount ethanol extraction 2 hours, merges twice decocting liquid, filters to get filtrate; Decompression recycling ethanol, becomes extractum shape.

B, Rhizoma Acori Graminei 1 part, Olibanum 1 part, Radix Bupleuri 2 parts, Dioscorea zingiberensis 2 parts, 3 parts, Pericarpium Zanthoxyli, Bulbus Lilii 1-part, 1 part, Poria, the Rhizoma Pinelliae 2 parts, Rhizoma Coptidis 2 parts, Radix Codonopsis 1 part, Herba Leonuri 1 part, Fructus Aurantii Immaturus 2 parts, the Radix Pulsatillae 1 part, the Radix Astragali 1 part, Radix Platycodonis 5 parts, Endothelium Corneum Gigeriae Galli 2 parts, Semen Plantaginis 1 part, Radix Sanguisorbae 1 part, Sanguis Draxonis 1 part, Fructus Trichosanthis 1 part, Fructus Evodiae 2 parts, 1 part, the Radix Rehmanniae, Semen Myristicae 1 part, Semen Raphani 5 parts of crude drug are added 80% soak with ethanol 2 hours of 5-10 times amount, extract 2 times; Heating extraction 2 hours, is concentrated into filtrate paste, when filtrate reduced in volume relative density is 80 DEG C 1.35 filtrate, decompression recycling ethanol, becomes extractum shape;

C, twice filtrate is merged to obtain extractum, mixes with the extractum that step a obtains, put into 80 DEG C, baking oven dry after cooling, grind to form fine powder;

The thin medicated powder that d, collection above-mentioned steps obtain is called in Mel and is made honey refining pill.

Embodiment 3

A, get crude drug Herba Taraxaci 5 parts, 5 parts, Radix Glycyrrhizae, Radix Notoginseng 1 part, Flos Lonicerae 5 parts, Cortex Acanthopancis 1 part, 5 parts, Fructus Jujubae, Fructus Lycii 1 part, Semen Ziziphi Spinosae 2 parts, Radix Bupleuri 2 parts, Dioscorea zingiberensis 2 parts, 3 parts, Pericarpium Zanthoxyli, Bulbus Lilii 1-part, 1 part, Poria, the Rhizoma Pinelliae 2 parts, Rhizoma Coptidis 2 parts, Radix Codonopsis 1 part, Herba Leonuri 1 part, Fructus Aurantii Immaturus 2 parts, the Radix Pulsatillae 1 part, the Radix Astragali 1 part, Radix Platycodonis 5 parts, Endothelium Corneum Gigeriae Galli 2 parts, Semen Plantaginis 1 part, Radix Sanguisorbae 1 part, Sanguis Draxonis 1 part, Fructus Trichosanthis 1 part, Fructus Evodiae 2 parts, 1 part, the Radix Rehmanniae, Semen Myristicae 1 part, Semen Raphani 5 parts, Rhizoma Acori Graminei 1 part, Olibanum 1 part is put into water and is soaked, heat is extracted 2 times, become extractum shape, for component 1,

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

Pharmacological toxicity is tested

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Traditional Chinese medicine preparation capsule agent of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Below in conjunction with clinical preliminary test, the present invention is done further, is described in detail:

Case selection: observing case is 110 routine patients, is hospital outpatient, inpatient, wherein man 69 example, female 41 example, 20 ~ 69 years old age, average 3 years old, the course of disease 1.5 ~ 8 years, average 4.5 years.

Diagnostic criteria:

(1) Western medicine diagnose standard is with reference to Hunan University's version " common disease diagnosis basis and curative effect judging standard " in 1999.(2) tcm diagnosis standard is with reference to " the disease of tcm Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine's issue.Patient has vague epigastralgia more, belch, pantothenic acid, dizzy, weak, indigestion and loss of appetite, abdominal distention, the symptoms such as lean body mass.

Outcome measure:

Recovery from illness: sings and symptoms disappears substantially, gastroscope check is the ulcer scars phase (S phase), helicobacter pylori (HP) (-).

Effective: sings and symptoms makes moderate progress, gastroscope check is the ulcer healing phase (H phase) (-).

Effective: symptom is slightly improved, gastroscope check is ulcer healing phase (H phase) HP (±).

Experimental procedure:

Be divided into A, B, C group three experimental grouies: A group: suffer from patient 31 example within gastric ulcer 1 year.B group: suffer from the gastric ulcer patient of 1 ~ 3 year 42 example.C group: suffer from the gastric ulcer patient of more than 3 years 37 example.

Drug administration method: A, B, C tri-groups of patients: the Chinese medicinal capsule of the treatment gastric ulcer that every day, the oral embodiment of the present invention 1 obtained, takes medicine three courses for the treatment of continuously.

Efficacy evaluation:

Invalid: symptom is without alleviation or DeGrain.

Effective: symptom obviously alleviates, attack times obviously reduces, successful.

Cure: gastric ulcer disappears, recovery from illness.

Therapeutic effect:

The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (10)

1. a Chinese medicine composition for prevention and therapy gastric ulcer, is characterized in that: be made up of following component:

Herba Taraxaci 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Notoginseng 1-30 part, Flos Lonicerae 1-30 part, Cortex Acanthopancis 1-30 part, Olibanum 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Dioscorea zingiberensis 1-30 part, Pericarpium Zanthoxyli 1-30 part, Bulbus Lilii 1-30 part, Poria 1-30 part, Rhizoma Pinelliae 1-30 part, Rhizoma Coptidis 1-30 part, Radix Codonopsis 1-30 part, Herba Leonuri 1-30 part, Fructus Aurantii Immaturus 1-30 part, Radix Pulsatillae 1-30 part, Radix Astragali 1-30 part, Fructus Jujubae 1-30 part, Radix Platycodonis 1-30 part, Endothelium Corneum Gigeriae Galli 1-30 part, Semen Ziziphi Spinosae 1-30 part, Semen Plantaginis 1-30 part, Radix Sanguisorbae 1-30 part, Sanguis Draxonis 1-30 part, Fructus Trichosanthis 1-30 part, Rhizoma Acori Graminei 1-30 part, Fructus Evodiae 1-30 part, Radix Rehmanniae 1-30 part, Semen Myristicae 1-30 part, Semen Raphani 1-30 part.

2. the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to claim 1, is characterized in that: be made up of each component of following parts by weight:

Herba Taraxaci 1-20 part, Radix Glycyrrhizae 1-20 part, Radix Notoginseng 1-10 part, Flos Lonicerae 1-30 part, Cortex Acanthopancis 1-30 part, Olibanum 1-30 part, Radix Bupleuri 1-30 part, Fructus Lycii 1-30 part, Dioscorea zingiberensis 1-30 part, Pericarpium Zanthoxyli 1-30 part, Bulbus Lilii 1-30 part, Poria 1-10 part, Rhizoma Pinelliae 1-30 part, Rhizoma Coptidis 1-15 part, Radix Codonopsis 1-10 part, Herba Leonuri 1-30 part, Fructus Aurantii Immaturus 1-30 part, Radix Pulsatillae 1-30 part, Radix Astragali 1-30 part, Fructus Jujubae 1-30 part, Radix Platycodonis 1-30 part, Endothelium Corneum Gigeriae Galli 1-20 part, Semen Ziziphi Spinosae 1-30 part, Semen Plantaginis 1-20 part, Radix Sanguisorbae 1-30 part, Sanguis Draxonis 1-30 part, Fructus Trichosanthis 1-30 part, Rhizoma Acori Graminei 1-30 part, Fructus Evodiae 1-30 part, Radix Rehmanniae 1-30 part, Semen Myristicae 1-20 part, Semen Raphani 1-20 part.

3. according to the Chinese medicine composition of a kind of prevention and therapy gastric ulcer described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:

Herba Taraxaci 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Notoginseng 1-10 part, Flos Lonicerae 5-20 part, Cortex Acanthopancis 1-20 part, Olibanum 1-20 part, Radix Bupleuri 2-20 part, Fructus Lycii 1-20 part, Dioscorea zingiberensis 2-30 part, Pericarpium Zanthoxyli 3-30 part, Bulbus Lilii 1-30 part, Poria 1-10 part, Rhizoma Pinelliae 2-10 part, Rhizoma Coptidis 2-15 part, Radix Codonopsis 1-10 part, Herba Leonuri 1-30 part, Fructus Aurantii Immaturus 2-10 part, Radix Pulsatillae 1-10 part, Radix Astragali 1-20 part, Fructus Jujubae 5-30 part, Radix Platycodonis 5-30 part, Endothelium Corneum Gigeriae Galli 2-10 part, Semen Ziziphi Spinosae 2-10 part, Semen Plantaginis 1-20 part, Radix Sanguisorbae 1-30 part, Sanguis Draxonis 1-30 part, Fructus Trichosanthis 1-10 part, Rhizoma Acori Graminei 1-30 part, Fructus Evodiae 2-20 part, Radix Rehmanniae 1-30 part, Semen Myristicae 1-20 part, Semen Raphani 5-20 part.

4. the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to claims 1 to 3, is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

5. the preparation method of the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to Claims 1-4, is characterized in that: prepared by described capsule comprises the following steps:

A, super micron mill are adopted to be ground into micropowders Herba Taraxaci, Radix Glycyrrhizae, Radix Notoginseng, Flos Lonicerae, Cortex Acanthopancis, Fructus Jujubae, Fructus Lycii, Semen Ziziphi Spinosae eight kinds of crude drug;

B, Rhizoma Acori Graminei, Olibanum steaming process extract volatile oil, become crystalline powder;

C, all the other crude drug add the ethanol of 1-5 times amount, 50-100 DEG C of alcoholization 100 minutes, then add the water of 1-5 times amount, 80 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off, in the high temperature resistant high rejection rolling NF membrane of 300KDalton, is isolated the large particulate matter in filtrate and supernatant, supernatant concentration, is obtained mastic, dry mastic, pulverize to obtain powder;

D, the canned capsule of medicated powder that above-mentioned steps is collected.

6. the preparation method of the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to claim 5, it is characterized in that: in described step a, described crude drug is put into after pulverizer is pulverized and cross 200 order dusting covers, the enable fine powder amount by 200 mesh sieves is reaching 50%, collects by the raw material fine powder of 200 mesh sieves for subsequent use.

7. according to the preparation method of the Chinese medicine composition of a kind of prevention and therapy gastric ulcer described in claim 1 to 6, it is characterized in that: the honey that the dosage form of described preparation is refines pill, comprising of its preparation method:

A, first described crude drug Herba Taraxaci, Radix Glycyrrhizae, Radix Notoginseng, Flos Lonicerae, Cortex Acanthopancis, Fructus Jujubae, Fructus Lycii, spiny jujuba seed powder are broken into coarse powder and sieve, fine powder is for subsequent use; The coarse grain that do not sieve put into multi-function extractor add ethanol extraction 2 times extractum;

B, surplus stock medicine is added ethanol extraction 2 times;

C, twice filtrate is merged to obtain extractum, mixes with the extractum that step a obtains, put into 80 DEG C, baking oven dry after cooling, grind to form fine powder;

The thin medicated powder that d, collection above-mentioned steps obtain is called in Mel and is made honey refining pill.

8. the preparation method of the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to claim 7, it is characterized in that: in described step a, first crude drug Herba Taraxaci, Radix Glycyrrhizae, Radix Notoginseng, Flos Lonicerae, Cortex Acanthopancis, Fructus Jujubae, Fructus Lycii, spiny jujuba seed powder are broken into coarse powder and cross sieved 80 mesh sieves, the enable fine powder amount by 80 mesh sieves is reaching 40%, collects and obtains fine powder a by the fine powder of 80 mesh sieves; Again the coarse powder not by 80 mesh sieves is dropped into multi-function extractor and extract twice, first time adds 3-5 times amount ethanol extraction 2 hours, and second time adds 1-2 times amount ethanol extraction 2 hours, merges twice decocting liquid, filters to get filtrate; Decompression recycling ethanol, becomes extractum shape.

9. the preparation method of the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to claim 7, is characterized in that: in described step b, surplus stock medicine is added 80% soak with ethanol 2 hours of 5-10 times amount, extracts 2 times; Heating extraction 2 hours, is concentrated into filtrate paste, when filtrate reduced in volume relative density is 80 DEG C 1.35 filtrate, decompression recycling ethanol, becomes extractum shape.

10. the preparation method of the Chinese medicine composition of a kind of prevention and therapy gastric ulcer according to claim 1, is characterized in that: the dosage form of described Chinese medicine preparation is oral solutions, and its preparation process comprises:

A, get crude drug and put into water and soak, heat is extracted 2 times, and becoming extractum shape, is component 1;

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.