CN105497816A

CN105497816A - Traditional Chinese medicine preparation for treating atherosclerosis and preparation method thereof

Info

Publication number: CN105497816A
Application number: CN201610052679.8A
Authority: CN
Inventors: 姜少燕
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-20
Filing date: 2016-01-20
Publication date: 2016-04-20

Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating atherosclerosis. The traditional Chinese medicine preparation is prepared from gynostemma pentaphylla, liquorice roots, poria cocos, fructus lycii, leonurus, salviae miltiorrhizae, the rhizome of chuanxiong, seeds of wild jujubes, rhizoma alismatis, cassia seeds, platycodon grandiflorum, mint, schisandra chinensis, coptis chinensis, milkvetch roots, selfheal, houttuynia cordata, pseudo-ginseng, snake gourd fruits, cassia twigs, radix paeoniae alba, semen plantaginis, uncaria rhynchophylla, gastrodia elata, roses, radix bupleuri, turmeric and the like. Compared with the prior art, the traditional Chinese medicine preparation has the advantages of being good in treatment effect, low in cost, low in limitation, free of adverse reactions and the like. Effective ingredients of all the raw materials interact and coordinate, and the traditional Chinese medicine preparation has a good treatment effect on atherosclerosis. A traditional Chinese medicine preparation method is simple, precise in compatibility, moderate in medicine property, safe, free of side effects, low in cost, suitable for being taken by various people and convenient to apply and popularize in large area clinically.

Description

One treats atherosclerotic Chinese medicine preparation and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to one and treat atherosclerotic Chinese medicine preparation and preparation method thereof.

Background technology

Atherosclerosis is most important one common in one group of arteriosclerotic angiopathy, is characterized in getting involved arterial disease from inner membrance.General first have that lipid and compound saccharide gather, hemorrhage and thrombosis, proliferation of fibrous tissue and calcinosis, and having medial transformation gradually and calcification; pathological changes often involves elasticity and large medium muscular artery; be enough to obstructing arterial chamber once develop into, then the tissue supplied of this tremulous pulse or organ are by ischemia or necrosis.Because the lipid outward appearance gathered at endarterium is yellow medicated porridge sample, be therefore called atherosclerosis.

Atherosclerosis is exactly arterial wall deposited the lipid of one deck as milled congee sample, makes the pathological changes that arterial elasticity lowers, tube chamber narrows.Hypertension promotes that atherosclerosis occurs, the important factor of development, and tremulous pulse caused narrowly causes secondary hypertension because of atherosis.Therefore interact therebetween, promote mutually, on very close terms.Hypertension promotes atherosclerosis, is multiplely born in large, medium-sized artery, comprises these fortress passages such as the coronary artery of heart, the cerebral arteries of head.Hypertension causes blood to impact tunica intima, causes tube wall thickening, tube chamber attenuates.Tube wall inner membrance impaired rear be easily cholesterol, lipidosis, increased the weight of the formation of atherosclerotic plaque.Therefore, hypertension is atherosclerotic risk factor.

Atherosclerosis is arteriosclerotic one, and the yellow substance containing cholesterol, class fat etc. appears in large, medium-sized artery inner membrance, and how by fat metabolic disturbance, neural blood vessel functional disorder causes.Often cause thrombosis, blood supply disorder etc.Also cry atherosis.

Atherosclerotic treatment often adopts: (1) general treatment: reasonable diet: diet total amount of heat should too highly not prevent overweight; Adhere to appropriate physical exertion; Reasonable arrangement work and life; Advocate non-smoking, can a small amount of wine etc. be drunk; (2) susceptible factor is controlled: as suffered from diabetes, blood glucose should being controlled in time, comprise diet control.The hypoglycemic medicine of type ii diabetes should be advisable not cause hyperinsulinemia; Then should give depressor if any hypertension, make blood pressure be down to proper level, increase if any cholesterolemia, then should control hypercholesterolemia and suitably give fat-reducing medicament.(3) blood lipid-lowering medicine treatment: 1, Statins 2, cholestyramine, 3, nicotinic acid.4, unsaturated fatty acid.5, propylene glycol alginate sodium sulfate.(4) Anti-platelet therapy: 1, aspirin.2, persantin etc.There is the shortcomings such as side effect is large in western medicine, and Chinese medicine is suppressing to have in atherosclerotic process unique advantage, is worthy of popularization.

Through a large amount of clinical practice and consult pertinent literature, inventor think the deficient and the liver failing to maintain the normal flow of QI of the heart, lung, spleen, kidney be AS occur basic, expectorant is turbid, blood stasis, pyretic toxicity are atherosclerotic key pathological factor.Atherosclerotic generation, development are on the basis that internal organs are deficient, and expectorant is turbid, blood stasis, pyretic toxicity are interior raw, and stagnate blood vessels, and damage venation, causes sering dull and heavy for a long time, and blood vessels lose soft, and very then vascular is narrow, and obturation is obstructed.Therefore, evil stagnant blood arteries and veins, venation is damaged, and sering is dull and heavy, and it is that atherosclerotic pathogenesis is crucial that blood vessels lose soft.On the basis that cardiopulmonary spleen is suffered from a deficiency of the kidney, stop being atherosclerotic potential pathogenic factors in the turbid interior Sheng of expectorant, blood stasis, phlegm-damp stays poly-blood vessels, and raw in blood stasis, venation is damaged, and Atheromatosis reason process starts thereupon.The turbid stasis of blood of phlegm-damp is heat-transformation poison with the passing of time, multiple causes void because of real again, deficiently constantly increases the weight of.Along with pathological changes further develops, expectorant stasis of blood knot, venation is obstructed obviously, and sering is dull and heavy, vascular narrow very then inaccessible obstructed be atherosclerotic most severe stage.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides one and treating atherosclerotic Chinese medicine preparation, there is significant curative effect.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: one treats atherosclerotic Chinese medicine preparation, is made up of following component:

Herb Gynostemmae Pentaphylli 1-30 part, Radix Glycyrrhizae 1-30 part, Poria 1-30 part, Fructus Lycii 1-30 part, Herba Leonuri 1-30 part, Radix Salviae Miltiorrhizae 1-30 part, Rhizoma Chuanxiong 1-30 part, Semen Ziziphi Spinosae 1-30 part, Rhizoma Alismatis 1-30 part, Semen Cassiae 1-30 part, Radix Platycodonis 1-30 part, Herba Menthae 1-30 part, Fructus Schisandrae Chinensis 1-30 part, Rhizoma Coptidis 1-30 part, Radix Astragali 1-30 part, Spica Prunellae 1-30 part, Herba Houttuyniae 1-30 part, Radix Notoginseng 1-30 part, Fructus Trichosanthis 1-30 part, Ramulus Cinnamomi 1-30 part, Radix Paeoniae Alba 1-30 part, Semen Plantaginis 1-30 part, Ramulus Uncariae Cum Uncis 1-30 part, Rhizoma Gastrodiae 1-30 part, Flos Rosae Rugosae 1-30 part, Radix Bupleuri 1-30 part, Rhizoma Curcumae Longae 1-30 part, Bulbus Allii Macrostemonis 1-30 part, Radix Rehmanniae Preparata 1-30 part, Pheretima 1-30 part, Caulis Spatholobi 1-30 part, Semen Persicae 1-30 part, Radix Cynanchi Paniculati 1-30 part, Radix Rhodiolae 1-30 part, Radix Puerariae 1-30 part, Rhizoma Acori Graminei 1-30 part, Rhizoma Pinelliae 1-30 part, Flos Lonicerae 1-30 part, Flos Campsis 1-30 part, Radix Cynanchi Atrati 1-30 part.

The atherosclerotic Chinese medicine composition of described treatment, in Chinese medicine preparation described in it, the parts by weight of various crude drug can be preferably: Herb Gynostemmae Pentaphylli 1-20 part, Radix Glycyrrhizae 1-20 part, Poria 1-20 part, Fructus Lycii 1-20 part, Herba Leonuri 1-20 part, Radix Salviae Miltiorrhizae 1-20 part, Rhizoma Chuanxiong 1-20 part, Semen Ziziphi Spinosae 1-20 part, Rhizoma Alismatis 1-20 part, Semen Cassiae 1-20 part, Radix Platycodonis 1-20 part, Herba Menthae 1-20 part, Fructus Schisandrae Chinensis 1-20 part, Rhizoma Coptidis 1-20 part, Radix Astragali 1-20 part, Spica Prunellae 1-20 part, Herba Houttuyniae 1-20 part, Radix Notoginseng 1-20 part, Fructus Trichosanthis 1-20 part, Ramulus Cinnamomi 1-20 part, Radix Paeoniae Alba 1-20 part, Semen Plantaginis 1-20 part, Ramulus Uncariae Cum Uncis 1-20 part, Rhizoma Gastrodiae 1-20 part, Flos Rosae Rugosae 1-20 part, Radix Bupleuri 1-20 part, Rhizoma Curcumae Longae 1-20 part, Bulbus Allii Macrostemonis 1-20 part, Radix Rehmanniae Preparata 1-20 part, Pheretima 1-20 part, Caulis Spatholobi 1-20 part, Semen Persicae 1-20 part, Radix Cynanchi Paniculati 1-20 part, Radix Rhodiolae 1-20 part, Radix Puerariae 1-20 part, Rhizoma Acori Graminei 1-20 part, Rhizoma Pinelliae 1-20 part, Flos Lonicerae 1-20 part, Flos Campsis 1-20 part, Radix Cynanchi Atrati 1-20 part.

The atherosclerotic Chinese medicine composition of described treatment, in Chinese medicine preparation described in it, the parts by weight of various crude drug can also be preferably: Herb Gynostemmae Pentaphylli 1-10 part, Radix Glycyrrhizae 1-10 part, Poria 1-10 part, Fructus Lycii 1-10 part, Herba Leonuri 1-10 part, Radix Salviae Miltiorrhizae 1-10 part, Rhizoma Chuanxiong 1-10 part, Semen Ziziphi Spinosae 1-10 part, Rhizoma Alismatis 1-10 part, Semen Cassiae 1-10 part, Radix Platycodonis 1-10 part, Herba Menthae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Rhizoma Coptidis 1-10 part, Radix Astragali 1-10 part, Spica Prunellae 1-10 part, Herba Houttuyniae 1-10 part, Radix Notoginseng 1-10 part, Fructus Trichosanthis 1-10 part, Ramulus Cinnamomi 1-10 part, Radix Paeoniae Alba 1-10 part, Semen Plantaginis 1-10 part, Ramulus Uncariae Cum Uncis 1-10 part, Rhizoma Gastrodiae 1-10 part, Flos Rosae Rugosae 1-10 part, Radix Bupleuri 1-10 part, Rhizoma Curcumae Longae 1-10 part, Bulbus Allii Macrostemonis 1-10 part, Radix Rehmanniae Preparata 1-10 part, Pheretima 1-10 part, Caulis Spatholobi 1-10 part, Semen Persicae 1-10 part, Radix Cynanchi Paniculati 1-10 part, Radix Rhodiolae 1-10 part, Radix Puerariae 1-10 part, Rhizoma Acori Graminei 1-10 part, Rhizoma Pinelliae 1-10 part, Flos Lonicerae 1-10 part, Flos Campsis 1-10 part, Radix Cynanchi Atrati 1-10 part.

The atherosclerotic Chinese medicine composition of described treatment, the dosage form of Chinese medicine preparation described in it can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

For solving the problems of the technologies described above, the present invention also provides the preparation method for the treatment of atherosclerotic Chinese medicine composition, and described preparation formulation is oral solutions, comprising of its preparation method:

A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;

B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.

In described step a, get raw material to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-180 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.

In described step b, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.

In described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.

For solving the problems of the technologies described above, the present invention also provides the preparation method for the treatment of atherosclerotic Chinese medicine composition, and described preparation formulation is capsule, comprising of its preparation method:

A. described raw material is put into pulverizer grinding and sieving;

B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;

C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The medicated powder that mixing sieves obtains incapsulates and is made as capsule.

For solving the problems of the technologies described above, the present invention also provides the preparation method for the treatment of atherosclerotic Chinese medicine composition, and the dosage form of described endo-medicine is pill, and its preparation process comprises:

A. described crude drug is mixed, chopping, cross 120 mesh sieves, obtain thin medicated powder for subsequent use;

B. unsifted coarse powder is soaked in ethanol and extract 2 times;

C. the medicinal residues after above-mentioned steps extraction are got again, the heating and refluxing extraction that adds water 2 times;

D. merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol becomes extractum, obtains thin medicated powder merge and add Mel and be twisted into pill with a step.

The atherosclerotic Chinese medicine composition of described treatment, the using method of Chinese medicine described in it is, the present invention decocts decoction when taking, and every day 1 dose, decocting takes at twice, and every 10 days is a course for the treatment of; When capsule, tablet, pill use, each 1,1 or 1 ball, every day three times, every 7 days is a course for the treatment of.

The present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.The each raw material active ingredient of the present invention influences each other, synergism, has good therapeutic effect to atherosclerotic.And Chinese medicinal preparation method of the present invention is simple, compatibility is rigorous, mild in medicine property and, safety has no side effect, with low cost, suitable all kinds of crowd takes, and is convenient to large scale application clinically.

Detailed description of the invention

Chinese medicine has the advantage of himself uniqueness in treatment atherosclerosis; Chinese medicine can Mutiple Targets, in all directions stabilize plaque; reduce blood fat, protect impaired endotheliocyte, inflammation-inhibiting state and play anticoagulation; oral drug therapy has no side effect, and some Chinese medicine can impel the reduction of plaque area by the effect of its hard masses softening and resolving or disappear.Along with the development of society, the quickening of rhythm of life, the change of dietary structure, the incidence rate of the diseases such as obesity, hypertension, hyperlipemia, diabetes rises gradually, and the incidence rate of arteriosclerosis also obviously raises.Arteriosclerosis problems demand solves.But the general composition of raw materials of the arteriosclerotic medicine of existing treatment by Chinese herbs is more, complicated process of preparation, quality control difficulties, and dose is more, curative effect is dissatisfied.

Herb Gynostemmae Pentaphylli: nature and flavor: bitter in the mouth; Micro-sweet; Cool in nature.Gui Jing: return lung; Spleen; Kidney channel.Function cures mainly: heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.

Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Poria: nature and flavor: sweet light is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.1. Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters bladder, kidney, lung." 3. " Thunder God concocts property of medicine solution ": " enters lung, spleen, small intestinal three warp.It is few cloudy that " 4. " Bencao Jingshu ": " enters brothers, the hands sun, lunar, the Yangming Channel of foot." function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.

Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enters kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " enters liver, stomach two warp, double enter lung meridian." function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.1. TAO Hong-Jing: " nourishing the essence and strengthening QI, prosperous and powerful vagina." 2. " property of medicine opinion ": " energy tonification essence various symptoms and signs of deficiency, easy color, bleaches, and improving eyesight is calmed the nerves.3. " Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." 4. Wang Haogu: " main cardiopathia dry sensation in the pharynx, pained, taking fluids profusely yearningly, during nephropathy disappears." 5. " detailed outline ": " nourishing kidney, lung moistening, improving eyesight.″

Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding." return through: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.1. " herbal classic ": " main urticaria is itched." 2. Tang Materia Medica: " applies fourth and swells, and takes juice and makes fourth toxic swelling internal diabetes; Descend dead fetus in the uterus again, feeling of distension and oppression after main product; All assorted poison swell, and red trip etc. are swollen; Extracting juice such as bean drips in ear, main Ting ear; Middle a poisonous snake mentioned in ancient books snake venom, applies it." 3. supplement to the Herbal: " smashes Seedling, applies acute mastitis and dislikes the person of swelling and ache; Smash again Seedling strand juice clothes, water under main edema, hold concurrently vicious swollen." 4. amplification on Canon of Materia Medica: " manage property before puerperal all diseases, promoting the circulation of blood is nourished blood; Cream clothes are made in difficult labour.″

Radix Salviae Miltiorrhizae: nature and flavor: bitter, tepor.1. " herbal classic "; " bitter in the mouth, is slightly cold, nontoxic." 2. " WU Pu Bencao ": " qi primary: salty." 3. Lee is when it " medicine record ": " Great Cold." 4. " Bencao Jingshu ": " bitter in the mouth, flat, tepor." return through: enter the heart, Liver Channel.1. " detailed outline ": " few cloudy, the cloudy blood system medicine of fainting of hands." 2. " Bencao Jingshu ": " enters few cloudy, the meridian of Foot-JUE YIN of brothers.The medicine of " 3. " book on Chinese herbal medicine just ": " heart, spleen, liver, kidney blood system." function cures mainly: blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving.Control angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia, lump in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.1. " herbal classic ": " main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." 2. " WU Pu Bencao ": " controls cardiac and abdominal pain." 3. " not Lu ": " nourishes blood, and removes trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Exorcising stays heat, takes sharp people for a long time." 4. TAO Hong-Jing: " stain beverage it, treat migratory arthralgia."

Rhizoma Chuanxiong: nature and flavor: pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " WU Pu Bencao ": " Yellow Emperor, a legendary ruler, qi primary, Thunder God: pungent, nontoxic are fragrant.Bian Que: acid, nontoxic.Li Shi: raw temperature, ripe cold." 3. Tang Materia Medica: " bitter in the mouth is pungent." 4. " book on Chinese herbal medicine just ": " acrid in the mouth is micro-sweet, temperature." return through: enter liver, gallbladder meridian.1. Materia Medica of Decoction: " meridian of Foot-JUE YIN of starting with, shaoyang channel." 2. " medicineization justice ": " enters liver, spleen, three burnt three warps." function cures mainly: activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.1. " herbal classic ": " main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity." 2. " not Lu ": ", except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold.″

Semen Ziziphi Spinosae: nature and flavor: sweet is flat.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. amplification on Canon of Materia Medica: " tepor." 4. principle of Correct Diet: " sour in the mouth is sweet, flat." return through: enter the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": " sufficient the moon of fainting, few sun." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, liver, gallbladder four warp." function cures mainly: nourishing the liver, and mind calming is calmed the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.1. " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." 2. " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." 3. " property of medicine opinion ": " main muscles and bones wind, fries end and takes it as soup." 4. supplement to the Herbal: " sleeps, and how life makes, and must not sleep and fry." 5. Wang Haogu: " controls milk-livered sleeplessness, trembles with fear also, fries clothes; Control somnolence due to gallbladder-excess, heat also, use by life." 6. " book on Chinese herbal medicine converges and says ": " astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen.″

Rhizoma Alismatis: nature and flavor: sweet, cold.1. " herbal classic ": " sweet in the mouth, cold." 2. " not Lu ": " be salty, nontoxic." 9. " property of medicine opinion ": " bitter in the mouth." 4. " medicine origin ": " gas is put down, sweet in the mouth." 5. " book on Chinese herbal medicine covers bamboo fish trap ": " sweet acid, gas is trembled with fear." return through: enter kidney, urinary bladder channel.1. Materia Medica of Decoction: " sun of starting with, shaoyin channel." 2. " Amplification on Materia Medica is mended L and lost ": " enters the sufficient sun, shaoyin channel." 3. " Thunder God concocts property of medicine solution ": " enters bladder, kidney, three burnt, small intestinal four warps." 4. " book on Chinese herbal medicine is through mercapto ": " enters kidney, spleen." function cures mainly: diuretic, and eliminating dampness by diuresis expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.(1) promoting diuresis to eliminate damp pathogen: for oliguria, edema, the card such as dysentery and damp and hot stranguria with turbid discharge of retention of water-damp in the body.Control gastric to cut off the water and often join the Rhizoma Atractylodis Macrocephalae.Control Urethra astringent pain, dysuria and often join Caulis Akebiae, Poria.

Semen Cassiae: nature and flavor: bitter sweet, cool.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be bitter sweet, is slightly cold, nontoxic." 3. " book on Chinese herbal medicine just ": " mildly bitter flavor is micro-sweet, and property is put down, micro-cool." return through: enter liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter Liver Channel." 2. " Bencao Jingshu ": " liver meridian, also enters gallbladder, kidney." function cures mainly: liver heat removing, improving eyesight, diuretic, relieving constipation.Control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation.1. " herbal classic): " control optic atrohic blindness, the red tunica albuginea of the excessive skin of order, swelling ophthalmalgia, lacrimation, clothes benefit is with nothing left for a long time." 2. " not Lu ": " treats blue-purple lips." 3. " property of medicine opinion ": " sharp the five internal organs, except liver man warm." 4. " Japan hanako materia medica ": " helps irritability, beneficial smart water; Adjust end to be coated with, detumescence poison, Xie temple control headache, paste again the brain heart and stop epistaxis; Make pillow victory Semen sojae atricolor, control wind syndrome of head, improving eyesight." 5. " Amplification on Materia Medica addendum ": " antidotes against snake bite." 6. " the SHENGCAO property of medicine is standby to be wanted ": " controls children's's five kinds of child malnutrition, wipes tinea leprosy."

Radix Platycodonis: nature and flavor: toil is flat.1. " herbal classic ": " pungent, tepor." 2. " not Lu ": " be bitter, slightly poisonous." 3. " property of medicine opinion ": " is bitter, flat, nontoxic." return through: enter lung, stomach warp.1. Materia Medica of Decoction: " enter the few the moon of foot, hands is lunar." 2. " product remittance essence is wanted ": " row meridian of Foot-TAI YIN." 3. " Bencao Jingshu ": " starts with lunar, few cloudy, double enter the stomach channel of foot-Yang-ming." function cures mainly: open lung qi dispersing gas, evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery is suffered from abdominal pain.1. " herbal classic ": " main chest and hypochondrium is as lancination, and abdominal distention, borborygmus are faint, gas of throbbing with fear in terror." 2. " not Lu ": " sharp the five internal organs the intestines and stomach, gas of enriching blood, except cold and heat, migratory arthralgia, warming middle-JIAO rapid digestion of food, treats laryngopharynx pain." 3. " property of medicine opinion ": " controls the inferior dysentery, removing blood stasis, removes pneumatosis, and removing food stagnancy gathers, sputum, and main lung-heat tachypnea is coughed inverse, except cold type of pain in abdomen, and main attacked by pestiferous factors and pediatric epilepsy scared." 4. " Japan hanako materia medica ": " all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat."

Herba Menthae: nature and flavor: pungent is cool.1. " medicine origin ": " " curing mainly secret wanting " cloud, cool in nature, pungent." 2. " medical center bun is wanted ": " is pungent, cold." return through: enter lung, Liver Channel.1. Materia Medica of Decoction: " the large the moon of hands, JUE YIN meridian medicine." 2. " detailed outline ": " starts with less, lunar, foot is fainted the moon." 3. " book on Chinese herbal medicine is newly organized ": " enters lung and envelope two warp, also can enter liver, gallbladder." function cures mainly: dispelling wind, and heat radiation, wards off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.1. " property of medicine opinion ": " remove anger gas, toxophoric antiperspirant, removing blood stasis dysentery relieving, easing joint movement." 2. " a thousand pieces of gold dietetic therapy ": " but kidney qi, it is clean to make us implication perfume (or spice).The main poison that exorcises evil spirits, except labor fraud." 3. Sun Si invites: " is decocted soup and is washed dermatitis rhus." 4. Tang Materia Medica: " main harmful wind, diaphoresis.(controlling) bad odor distention and fullness in the abdomen.Cholera.Dyspepsia does not disappear, the therapeutic method to keep the adverse QI flowing downwards." 5. " Treatise on Dietetic Therapy ": " pestle juice takes, and goes heart wind heat.″

Fructus Schisandrae Chinensis: nature and flavor: acid, temperature.1. " herbal classic ": " sour in the mouth, temperature." 2. " not Lu ": " be nontoxic.The sweet acid of " 3. Tang Materia Medica: " skin and flesh, arduous in core, there is saline taste." 4. " Changsha medicine solution ": " micro-hardship of sour in the mouth is salty, and gas is puckery." return through: enter lung, kidney channel, 1. Materia Medica of Decoction: " starts with lunar, meridian of Foot-SHAO YIN." 2. " detailed outline ": " enters liver, the heart." function cures mainly: astringe the lung, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, and impairment caused by overstrain is won thin, emission, chronic diarrhea chronic dysentery.1. " herbal classic ": " main QI invigorating, cough with dyspnea, impairment caused by overstrain win degree, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence." 2. " not Lu ": " supports the five internal organs, heat extraction, flesh in raw the moon." 3. " Japan hanako materia medica ": " improving eyesight, warming the kidney, controls wind, and the therapeutic method to keep the adverse QI flowing downwards helps digestion, cramp caused by acute vomiting and diarrhea, mass beside the umbilicus renal mass cold air, consumer edema, and regurgitation, trusted subordinate's flatulence, quenches the thirst, heat clearing away and restlessness relieving, alcoholic intoxication, strengthening bone and muscle." 4. Li Gao: " promoting the production of body fluid to quench thirst.Control dysentery, invigorating primordial QI is not enough, receives the gas of dissipation, platycoria." 5. Wang Haogu: " controls dry coughing of breathing with cough, Zhuan Shui town sun."

Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Spica Prunellae: nature and flavor: pungent, bitter, cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

Herba Houttuyniae: nature and flavor: pungent, cold.1. " not Lu ": " acrid in the mouth, tepor." 2. 《 Lv Cliff rock book on Chinese herbal medicine ": " cool in nature, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is cold in nature, and bitter in the mouth is pungent." 4. " detailed outline ": " is pungent, and tepor is slightly poisonous." 5. " medical center bun is wanted ": " is sweet pungent salty." return through: 1. " Bencao Jingshu ": " enters meridian of Hand-TAI YIN." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung two warp." function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.1. " not Lu ": " main earwig is drowned skin ulcer.Simmer in " 2. " Japan hanako materia medica ": " phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle cylinder, deposited malignant boil is bald in vain." 3. 《 Lv Cliff rock book on Chinese herbal medicine ": " control greatly the vexed unrest of heatstroke latent heat, syncope." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls lung abscess cough band pus and blood, and expectorant has stench, large intestine pyretic toxicity, treats hemorrhoid." 5. " detailed outline ": " dispel the heat malicious carbuncle, skin ulcer hemorrhoid proctoptosis ， Duan Malaria disease, separates Nao poison." 6. " medical center bun is wanted ": " row water, assaults fortified position, goes miasma, expelling summer-heat.Treat snakeworm poison, control beriberi, carbuncle of bursting, blood stasis removing blood." 7. Chen Nian ancestral: " is raw smashes stopping vomiting blood.″

Radix Notoginseng: nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.

Fructus Trichosanthis: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

Ramulus Cinnamomi: nature and flavor: sweet, micro-hardship, cold.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

The Radix Paeoniae Alba: nature and flavor: picric acid is cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch: sweet, nontoxic.Qi primary: salty.Li Shi: Slight Cold.Thunder God: acid." 3. " not Lu ": " acid, is flatly slightly cold, slightly poisonous." return through: enter liver, spleen channel.1. " product remittance essence is wanted ": " row hands is lunar, meridian of Foot-TAI YIN." 2. " Bencao Jingshu ": " lunar guiding drug of brothers, enters liver, spleen blood system." function cures mainly: nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.1. " herbal classic ": " main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." 2. " not Lu ": " clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat time (controlling), and attacked by pestiferous factors is suffered from abdominal pain, lumbago." 3. " property of medicine opinion ": " controls pathogen of the lung gas, Fu Zhong Xu pain, and vim and vigour are gathered, and logical a surname's internal organs gather around gas, controls evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." 4. Tang Materia Medica: " beneficial woman's blood."

Semen Plantaginis: nature and flavor: sweet, cold.1. " herbal classic ": " sweet in the mouth, cold." 2. " not Lu ": " be salty, nontoxic." 3. " property of medicine opinion ": " is sweet, flat." 4. " medicineization justice ": " is lightly seasoned, and property is put down." return through: enter kidney, urinary bladder channel.1. " book on Chinese herbal medicine covers bamboo fish trap ": " enter bladder." 2. " Thunder God concocts property of medicine solution ": " enters liver, bladder, small intestinal three warp." 3. " Bencao Jingshu ": " enters kidney, liver, bladder three warp." function cures mainly: diuretic, heat clearing away, tomorrow, eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.1. " herbal classic ": " main stranguria due to disorder of QI, pain relieving, dredging water passages urine, except arthralgia chiefly caused by damp pathogen." 2. Collective Notes to the Canon of Materia medica: " main asthenia." 3. " not Lu ": " man's damaging the spleen and stomach, woman drenches drop, loss of appetite.Support lung reinforcing YIN-essence benefit essence.Swelling pain is treated in improving eyesight." 4. " property of medicine opinion ": " can remove pathogenic wind toxic, and the liver affected by pathogenic wind heat, malicious wind dotting punch order, swelling pain is hidden from view, and headache lacrimation, removes irritable feverish sensation of chest and heart." 5. " Japan hanako materia medica ": " diuresis drenches puckery, tonifying YANG.Control de-essence, vexed.The therapeutic method to keep the adverse QI flowing downwards." 6. " medicine origin ": " main urinary obstruction, leads little pathogenic heat in the bowels." 7. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " part of the body cavity above the diaphragm housing the heart and lungs that disappears is burning hot, and sealing rushes down." 8. " detailed outline ": " be heat-damp in summer dysentery only."

Ramulus Uncariae Cum Uncis: nature and flavor: sweet is cool.1. " not Lu ": " be slightly cold." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " another name for Sichuan Province book on Chinese herbal medicine ": " bitter in the mouth." return through: enter liver, heart channel.1. " detailed outline ": " hands, sufficient the moon of fainting.Few cloudy, the meridian of Foot-JUE YIN of " 2. " Bencao Jingshu ": " hands." function cures mainly: heat clearing away suppressing the hyperactive liver, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control pediatric epilepsy scared Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclamposia.1. " not Lu ": " main children's's cold and heat, infantile convulsion." 2. " property of medicine opinion ": " main children's's night crying due to fright in infant ， Chi Zong heat is stopped up." 3. " Japan hanako materia medica ": " controls infantile convulsive seizure due to fright erythroderma of newborn." 4. " detailed outline ": " large number of people revolves dizzy, suppressing liver-wind, and except heat in the heart, children's's infantile tic is suffered from abdominal pain, and sends out macule." 5. " book on Chinese herbal medicine is levied and wanted ": " relaxing muscles and tendons removes dizzy, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO."

Rhizoma Gastrodiae: nature and flavor: sweet is flat.1. " herbal classic ": " acrid in the mouth, temperature." 2. " property of medicine opinion ": " is nontoxic.Sweet in the mouth is flat." 3. " medicine origin ": " gas is put down, bitter in the mouth." return through: enter Liver Channel.1. " detailed outline ": " enter Liver Channel edema caused by disorder of QI." 2. " Thunder God concocts property of medicine solution ": " enters liver, bladder two warp." 3. " book on Chinese herbal medicine is newly organized ": " enters spleen, kidney, liver, gallbladder, heart channel." function cures mainly: endogenous wind stopping, arresting convulsion.Control dizzy pupil, wind syndrome of head is had a headache, numb limbs and tense tendons, hemiplegia, aphasia, pediatric epilepsy scared wind symptom.1. " herbal classic ": " main bad odor, takes physical strength profiting for a long time, long cloudy fertile strong." 2. " not Lu ": " subduing inflammation, lower distention and fullness, hernia, hematochezia." 3. " property of medicine opinion ": " controls cold air insensitive impediment, and paralysis is slow unsuccessful, and how in a trance language is, shies mental confusion more." 4. " Japan hanako materia medica ": " aid yang qi, mend five kinds of strain and seven kinds of impairment, promoting blood circulation, has one's ideas straightened out." 5. " Kaibao Bencao ": " main all rheumatism numbness, spasm of the limbs, children's's acute infantile convulsion, frightened gas, sharp waist knee joint, strong biceps." 6. Zhang Yuansu: " controls the empty dizziness and headache of wind.″

Flos Rosae Rugosae: nature and flavor: sweet micro-hardship, temperature. 1. Yao can become " food book on Chinese herbal medicine ": " sweet and slightly bitter taste, temperature, nontoxic." 2. " occupying diet spectrum with breath ": " sweet, acrid, warm." return through: " book on Chinese herbal medicine is new again ": " enters liver, spleen two warp." function cures mainly: resolving depression of regulating the flow of vital energy, and blood dissipating blood stasis.Treating the liver peratodynia, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.1. Yao can become " food book on Chinese herbal medicine ": " gas of the evil that exorcises evil spirits, the fragrance of food is sweet and refreshing, makes us refreshing refreshing for main sharp lung spleen, the liver benefiting gallbladder." 2. " property of medicine is examined ": " promoting the circulation of blood removing mass, damage stasis of blood pain, infusing drugs in wine is drunk." 3. " detailed outline is picked up any lost article from the road ": " and blood, promoting the circulation of blood, regulates the flow of vital energy.Control migratory arthralgia.The strongly fragrant gas of " 4. " book on Chinese herbal medicine is new again ": " soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing.Control cold type of pain in abdomen, gastral cavilty is long-pending cold, and holding concurrently can removing blood stasis." 5. " occupying diet spectrum with breath ": " invigorates blood circulation in adjusting, and Shu Yujie, wards off dirty, regulating liver-QI.Wine brewing can disappear nodules of the breast." 6. " modern Practical Chinese medicinal ": " for married woman's menorrhagia, leucorrhea with red and white discharge and general enteritis dysentery etc." 7. " Shandong Chinese medicine ": " is controlled and is looked up with eyes wide open peratodynia, nausea and vomiting, dyspepsia, has loose bowels, and dispute gruel is broken, spits blood, fasting dysentery.″

Radix Bupleuri: nature and flavor: bitter, cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be slightly cold, nontoxic." 3. " Japan hanako materia medica ": " sweet in the mouth." return through: enter liver, gallbladder meridian.1. " pearl sac ": " enter foot-shaoyang gallbladder, liver meridian, hands lacks sun three Jiao, hands faints cloudy percardium." 2. " book on Chinese herbal medicine is new again ": " enters the heart, liver, spleen three warp." function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.1. " herbal classic ": " stagnation of QI in main trusted subordinate's the intestines and stomach, diet gathers, and cold and heat pathogen, pushes away Chen Zhixin." 2. " not Lu ": ", except dysphoria with smothery sensation under the typhoid fever heart, all expectorant accumulation of heats be real, evil inverse in the heart, five hide between faint breath, large intestine stops amassing, watery distension, and arthralgia chiefly caused by damp pathogen contracture.Also can do to bathe soup." 3. " property of medicine opinion ": " Zhi Relao arthralgia with restlessness, steam, shoulder and back ache, declares smooth vim and vigour, and tired win is thin; The main therapeutic method to keep the adverse QI flowing downwards helps digestion, and time main, in disease, exterior-heat is not understood, and singly boils clothes." 4. " prescriptions worth thousand gold ": " Seedling juice controls deafness, fills with in ear.Painful abdominal mass in " 5. " four tones of standard Chinese pronunciation book on Chinese herbal medicine ": " main expectorant billows, the breast side of body.″

Rhizoma Curcumae Longae: nature and flavor: arduous, temperature.1. Tang Materia Medica: " acrid in the mouth is bitter, Great Cold, nontoxic." 2. supplement to the Herbal: " acrid in the mouth, temperature, nontoxic." 3. Li Gao: " bitter but sweet flavor is pungent, Great Cold, nontoxic." 4. " Dong-eui-bo-gam ": " is hot in nature, and acrid in the mouth is bitter, nontoxic." return through: enter spleen, Liver Channel.1. " detailed outline ": " enter the heart, spleen." 2. " Thunder God concocts property of medicine solution ": " enters the heart, lung two warp." 3. " Bencao Jingshu ": " enters lunar, the moon of fainting of foot." function cures mainly: removing blood stasis, and circulation of qi promoting is stimulated the menstrual flow, pain relieving.Control trusted subordinate's feeling of fullness distending pain, brachialgia, lump in the abdomen, women's blood stasis amenorrhea, puerperal, the stasis of blood stopped stomachache, injury from falling down, carbuncle.Breast for qi depression to blood stasis is suffered from abdominal pain, dysmenorrhea and limbs pain, often joins Rhizoma Corydalis, Rhizoma Cyperi.1. Tang Materia Medica: " main trusted subordinate ties long-pending, and chronic infectious disease is disobedient, the therapeutic method to keep the adverse QI flowing downwards, removing blood stasis, except wind heat, subduing inflammation.Power is strong in Radix Curcumae." 2. " Japan hanako materia medica ": " controls lump in the abdomen clot, carbuncle, and logical menstruation, controls to fall and flutter blood stasis, detumescence poison; Only storm wind pain cold air, lower food." 3. " Bencao Tujing ": " control flatulence and puerperal deteriorated blood make a psychological attack."

Bulbus Allii Macrostemonis: nature and flavor: arduous, temperature.1. " wooden warp ": " acrid in the mouth, temperature." 2. " not Lu ": " be bitter, and temperature is nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter in the mouth is pungent, temperature, sliding, nontoxic." 4. " medical center bun is wanted ":

" sweet misery, temperature." return through: 1. Materia Medica of Decoction: " enters meridian of Hand-YANG MING." 2. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian, heart channel of Hand-Shaoyin." function cures mainly: regulate the flow of vital energy, and the chest stuffiness relieving activates yang, eliminating stagnation.Control the thorough back of the body of obstruction of qi in the chest and cardialgia, gastral cavity painful abdominal mass is not relaxed, and retches, heavy after dysentery, furuncle.1. " herbal classic ": " main incised wound skin ulcer loses." 2. " not Lu ": " be attributed to bone.Except cold and heat, anhydrate gas, warming middle-JIAO eliminating stagnation.Wind and cold edema in all skin ulcers, to be coated with it." 3. " a thousand pieces of gold dietetic therapy ": " energy granulation promoting meat, sharp puerpera.A fishbone or other bone caught in the throat is not swallowing person, then going of food." 4. Tang materia medica ": " white person mends and beautiful, the main incised wound of red person and phoenix." 5. " Treatise on Dietetic Therapy ": " controls married woman's leucorrhea with red and white discharge.During " 6. supplement to the Herbal: " is adjusted, main chronic diarrhea is not recovered, normal evil person in large abdomen, but cooks it more." 7. " Bencao Tujing ": " tonify deficiency, removing toxic substances." " main foot gas; Boil and drink it with straw mat woman, easily produce.″

Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Pheretima: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Caulis Spatholobi: nature and flavor: bitter sweet, temperature.1. " decoction pieces is newly joined ": " pained fragrant micro-sweet." 2. " book on Chinese herbal medicine justice ": " temperature." 3. Jiangxi " Chinese herbology ": " bitter temperature is micro-sweet." return through: " book on Chinese herbal medicine is new again ": " enters the heart, spleen two warp." function cures mainly: invigorate blood circulation, relaxing muscles and tendons.Control soreness of waist and knee joint, paralysis and numbness, menoxenia.1. " detailed outline is picked up any lost article from the road ": " invigorate blood circulation, warm waist knee joint, paralysis." 2. " book on Chinese herbal medicine is new again ": " dry stomach of invigorating middle warmer." 3. " decoction pieces is newly joined ": " blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.The hematonic that " 4. " modern Practical Chinese medicinal ": " is robustness, is applicable to anemicus neural paralysis disease, as limbs and soreness of waist and knee joint, apathetic etc.Again for menoxenia, menstruation apolipsis etc., have the effect of invigorating blood circulation analgesia."

Semen Persicae: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter but sweet flavor is pungent, flat, nontoxic." return through: enter the heart, liver, large intestine channel.1. Materia Medica of Decoction: " start with, meridian of Foot-JUE YIN." 2. " Thunder God concocts property of medicine solution ": " enters liver, large intestine two warp." 3. " book on Chinese herbal medicine is through separating ": " enters lung meridian, heart channel of Hand-Shaoyin, spleen meridian." function cures mainly: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.1. " herbal classic ": " main blood stasis, blood closes lump in the abdomen, pathogen, kills small worm." 2. " not Lu ": " only cough with dyspnea, disappear hardness in the epigastrium, and except soldier hits blood cruelly, broken lump in the abdomen, promotes blood circulation, pain relieving." 3. the Meng numerous: " kills three worms, only pained." 4. " medicine origin ": " controls stool blood agglomeration."

Radix Cynanchi Paniculati: nature and flavor: pungent, temperature.1. " herbal classic ": " acrid in the mouth, temperature." 2. " not Lu ": " be nontoxic." function cures mainly: analgesia, cough-relieving, inducing diuresis to remove edema, promoting blood circulation and detoxication.Treat for stomachache, toothache, rheumatalgia, abdominal pain in menstruation, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, venom.1, for various pain diseases such as rheumatic arthralgia, lumbago, traumatic injury pain, abdominal pain, toothache.Radix Cynanchi Paniculati has good wind-expelling pain-stopping effect, is widely used for the various pain diseases caused by rheumatism, cold coagulation, the stagnation of QI, blood stasis.In recent years also for postoperative pain and cancerous protuberance pain, there is certain analgesic effect.Can apply by single, or with demonstrate,proving the relevant medicine of compatibility.2, by dermatosiss such as eczema, rubella wheal, stubborn dermatitis.This product has dispelling wind for relieving itching effect.Can be alone for oral administration or decoct soup washout, also can the medicine of the eliminating damp-heat such as compatibility Radix Sophorae Flavescentis, the Fructus Kochiae, Cortex Dictamni.In addition, this product can also antidote against snake bite, and controls venom.Can with Herba Lobeliae Chinensis with using for oral administration or external.

Radix Rhodiolae: nature and flavor: cold; Sweet; Puckery.Gui Jing: lung meridian.Function cures mainly: QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.

Radix Puerariae: nature and flavor: Gan Xin is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic.To take root juice, Great Cold." 3. " detailed outline ": " Gan Xin is flat, nontoxic." return through: enter spleen, stomach warp.1. Zhang Yuansu: " current Foot yangming Channel." 2. " book on Chinese herbal medicine is newly organized ": " enters stomach, enters lung again." 3. " book on Chinese herbal medicine is looked for the truth ": " enters stomach, double enter spleen." 4. " key medicine divides agent ": " enters stomach, bladder two warp, double enter spleen channel." function cures mainly: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, and relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.1. " herbal classic ": " master quenches one's thirst, and body is too warm, vomiting, and all numbness plays cloudy gas, separates all poison." 2. " not Lu ": " excessive cold invading middle-JIAO(the spleen and stomach) wind headache of curing the wound, expelling pathogenic factors from muscles, delivers, and perspires, loosing the interspaces of skin and muscles.Treat incised wound, pain relieving, side of body wind pain." " is taken root juice, and treatment is quenched one's thirst, typhoid fever high fever." 3. Collective Notes to the Canon of Materia medica: " kills Herba Gelsemii Elegantis, Fructus Crotonis, hundred poison of drug." 4. TAO Hong-Jing: " survivor smash extracting juice and drink it, separates epidemic febrile disease heating.Radix Puerariae is bits, treats incised wound and to break blood, also treat malaria and skin ulcer." 5. " property of medicine opinion ": " control sky capable on gas, vomiting, whetting the appetite, principal solution alcoholism, only excessive thirst.Endure bits and control incised wound, when controlling, disease is antipyretic.The ， Zhu Rabid-dog Canis familiaris L. of " 6. Tang Materia Medica: " end clothes nibbles, and it is good to drink its juice."

Rhizoma Acori Graminei: nature and flavor: pungent, tepor, 1. " herbal classic ": " pungent, temperature." 2. " another mouth record ": " is nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is pungent, nontoxic." return through entrance, liver, spleen channel.1. " detailed outline ": " few cloudy, sufficient the moon of fainting of hands." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, bladder three warp." 3. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian." function cures mainly: have one's ideas straightened out, and eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery, coma epilepsy, forgetful deafness not hungry for gastral cavity painful abdominal mass.1. " herbal classic ": " happy hole, tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity, goes out speech for main anemofrigid-damp arthralgia, cough with dyspnea." 2. " not Lu ": " main deafness, carbuncle skin ulcer, warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can do to bathe soup.Audition improvement order, beneficial intelligence." 3. " property of medicine opinion ": " dispelling the wind and dampness pathogens insensitive impediment, tinnitus, wind syndrome of head, under tear, kills parasites, controls malignant boil scabies scabies.″

The Rhizoma Pinelliae: nature and flavor: pungent, temperature; Poisonous.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

Herb Gynostemmae Pentaphylli 2 parts, 2 parts, Radix Glycyrrhizae, 3 parts, Poria, Fructus Lycii 8 parts, Herba Leonuri 9 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Chuanxiong 2 parts, Semen Ziziphi Spinosae 3 parts, Rhizoma Alismatis 3 parts, Semen Cassiae 4 parts, Radix Platycodonis 5 parts, Herba Menthae 2 parts, Fructus Schisandrae Chinensis 2 parts, Rhizoma Coptidis 3 parts, the Radix Astragali 2 parts, Spica Prunellae 2 parts, Herba Houttuyniae 1 part, Radix Notoginseng 3 parts, Fructus Trichosanthis 6 parts, Ramulus Cinnamomi 4 parts, the Radix Paeoniae Alba 7 parts, Semen Plantaginis 2 parts, Ramulus Uncariae Cum Uncis 1 part, 2 parts, Rhizoma Gastrodiae, Flos Rosae Rugosae 3 parts, Radix Bupleuri 6 parts, 3 parts, Rhizoma Curcumae Longae, Bulbus Allii Macrostemonis 4 parts, Radix Rehmanniae Preparata 5 parts, Pheretima 2 parts, Caulis Spatholobi 2 parts, 3 parts, Semen Persicae, Radix Cynanchi Paniculati 3 parts, Radix Rhodiolae 2 parts, Radix Puerariae 4 parts, Rhizoma Acori Graminei 3 parts, the Rhizoma Pinelliae 6 parts, Flos Lonicerae 4 parts, Flos Campsis 6 parts, Radix Cynanchi Atrati 4 parts.

Described preparation formulation is oral solutions, comprising of its preparation method:

A, get raw material and add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1;

10 times of water gagings put into by b, the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2;

C, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.

Embodiment 2

A, get crude drug Herb Gynostemmae Pentaphylli 2 parts, 2 parts, Radix Glycyrrhizae, 3 parts, Poria, Fructus Lycii 8 parts, Herba Leonuri 9 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Chuanxiong 2 parts, Semen Ziziphi Spinosae 3 parts, Rhizoma Alismatis 3 parts, Semen Cassiae 4 parts, Radix Platycodonis 5 parts, Herba Menthae 2 parts, Fructus Schisandrae Chinensis 2 parts, Rhizoma Coptidis 3 parts, the Radix Astragali 2 parts, Spica Prunellae 2 parts, Herba Houttuyniae 1 part, Radix Notoginseng 3 parts, Fructus Trichosanthis 6 parts, Ramulus Cinnamomi 4 parts, the Radix Paeoniae Alba 7 parts, Semen Plantaginis 2 parts, Ramulus Uncariae Cum Uncis 1 part, 2 parts, Rhizoma Gastrodiae, Flos Rosae Rugosae 3 parts, Radix Bupleuri 6 parts, 3 parts, Rhizoma Curcumae Longae, Bulbus Allii Macrostemonis 4 parts, Radix Rehmanniae Preparata 5 parts, Pheretima 2 parts, Caulis Spatholobi 2 parts, 3 parts, Semen Persicae, Radix Cynanchi Paniculati 3 parts, Radix Rhodiolae 2 parts, Radix Puerariae 4 parts, Rhizoma Acori Graminei 3 parts, the Rhizoma Pinelliae 6 parts, Flos Lonicerae 4 parts, Flos Campsis 6 parts, Radix Cynanchi Atrati 3 parts enters in water to soak, heat is extracted 2 times, become extractum shape, for component 1,

B, medicinal residues ethanol extraction 1 time, thickening filtration is extractum shape, is component 2;

C, above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, and then vacuum freezing seals and get final product.

Embodiment 3

Herb Gynostemmae Pentaphylli 1 part, 10 parts, Radix Glycyrrhizae, 3 parts, Poria, Fructus Lycii 10 parts, Herba Leonuri 4 parts, Radix Salviae Miltiorrhizae 1 part, Rhizoma Chuanxiong 2 parts, Semen Ziziphi Spinosae 5 parts, Rhizoma Alismatis 4 parts, Semen Cassiae 5 parts, Radix Platycodonis 5 parts, Herba Menthae 2 parts, Fructus Schisandrae Chinensis 3 parts, Rhizoma Coptidis 6 parts, the Radix Astragali 3 parts, Spica Prunellae 2 parts, Herba Houttuyniae 1 part, Radix Notoginseng 3 parts, Fructus Trichosanthis 7 parts, Ramulus Cinnamomi 4 parts, the Radix Paeoniae Alba 7 parts, Semen Plantaginis 2 parts, Ramulus Uncariae Cum Uncis 1 part, 2 parts, Rhizoma Gastrodiae, Flos Rosae Rugosae 3 parts, Radix Bupleuri 6 parts, 3 parts, Rhizoma Curcumae Longae, Bulbus Allii Macrostemonis 4 parts, Radix Rehmanniae Preparata 5 parts, Pheretima 2 parts, Caulis Spatholobi 2 parts, 3 parts, Semen Persicae, Radix Cynanchi Paniculati 3 parts, Radix Rhodiolae 2 parts, Radix Puerariae 4 parts, Rhizoma Acori Graminei 3 parts, the Rhizoma Pinelliae 6 parts, Flos Lonicerae 4 parts, Flos Campsis 2 parts, Radix Cynanchi Atrati 1 part.

Pharmacological toxicity is tested

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Traditional Chinese medicine preparation capsule agent of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

Clinical trial

Physical data

In order to verify the effect of Chinese medicine composition of the present invention, in the joint research of the several vascular surgery expert in Qingdao City with under instructing, from year November in March, 2008 to 2015, accept atherosis patient 237 example of early stage occlusive peripheral arterial for medical treatment.All cases, all through health check-up, checks the test of the intensity of pulsation of foot dorsal artery, finger pressure nail matrix, surveys ankle systolic arterial pressure and the multiple inspection such as brachial artery systolic pressure ratio and laboratory auxiliary examination and make a definite diagnosis, and bad without severe cardiac, Liver and kidney function.Be divided into treatment group 121 example at random, wherein 20 ~ 65 years old age, 54 years old mean age.Matched group 116 example, wherein 30 ~ 71 years old age, 55 years old mean age.Two groups in sex, age, the state of an illness etc. all without significant difference (P > 0.05), there is comparability, refer to table 1.

Note: two groups are compared: P > 0.05

Diagnostic criteria:

The present invention formulates with reference to the diagnostic criteria of the internal medicine 367 pages professional for 8 years systems and 7 years clinical medicine processed etc. of Wang Jiyao chief editor.1. the age is many more than 50 years old; 2. hyperlipemia, diabetes or hypertension history is had; 3. intermittent claudication, acroesthesia companion artery of lower extremity beat weaken, disappear, asymmetric, ankle/brachial artery systolic pressure index < 1.0; 4. Doppler checks the positive.

Therapeutic Method:

Matched group: adopt western medicine routine treatment: control blood fat simvastatin or fenofibrate, control blood glucose glipizide or insulin, control blood pressure enalapril, Nifedipine sustained release tablets, improve blood samples of patients circulation low molecular dextran, other takes symptomatic treatment.

Treatment group: take the embodiment of the present invention 3 medicine, every natural gift three oral meals 10 days are a course for the treatment of.Two groups treat 10 weeks respectively after, observe clinical symptoms and every auxiliary examination etc. improvement situation.

Therapeutic evaluation:

Effective: clinical symptom disappearance, finger pressure nail matrix capillary filling time shortens, and survey ankle/upper arm index is close or equal 1; Pulsation of foot dorsal artery is close to normal or normal; Blood fat and blood pressure glycemic control is normal.

Effective: clinical symptoms disappears substantially, finger pressure nail matrix capillary filling time slightly extends or close to normal, survey ankle/upper arm index and be greater than more than 0.7; Pulsation of foot dorsal artery is close to normal; Blood fat and blood pressure blood glucose all controls close normal.

Invalid: clinical symptoms and finger pressure nail matrix capillary filling time are all not improved, survey ankle/upper arm index below 0.5; Pulsation of foot dorsal artery weakens or disappears.

Statistical method: data rate represents, adopts X2 inspection, with P < 0.05 for difference has statistical significance.

Result:

Before and after treatment, two groups of symptoms improvement situations compare

Treatment group takes the embodiment of the present invention 3 Chinese medicine composition, and clinical symptoms improvement rate (92.6%) is significantly better than matched group merely by clinical symptoms improvement rate (43.8%) after western medicine routine treatment, refers to table 2.

Before and after treatment, two groups of auxiliary examination results improvement are compared: refer to table 3

Note: two groups are compared: P > 0.05

Untoward reaction: matched group has 13 examples to occur dry cough, has 4 examples to occur that hypoglycemia is dizzy.Treatment group has no obvious adverse reaction.

Above data significantly describe that each raw material active ingredient of the present invention influences each other, synergism, have good therapeutic effect to atherosclerotic.The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims

1. treat an atherosclerotic Chinese medicine preparation, it is characterized in that: be made up of following component:

2. one according to claim 1 treats atherosclerotic Chinese medicine preparation, it is characterized in that: be made up of each component of following parts by weight:

Herb Gynostemmae Pentaphylli 1-20 part, Radix Glycyrrhizae 1-20 part, Poria 1-20 part, Fructus Lycii 1-20 part, Herba Leonuri 1-20 part, Radix Salviae Miltiorrhizae 1-20 part, Rhizoma Chuanxiong 1-20 part, Semen Ziziphi Spinosae 1-20 part, Rhizoma Alismatis 1-20 part, Semen Cassiae 1-20 part, Radix Platycodonis 1-20 part, Herba Menthae 1-20 part, Fructus Schisandrae Chinensis 1-20 part, Rhizoma Coptidis 1-20 part, Radix Astragali 1-20 part, Spica Prunellae 1-20 part, Herba Houttuyniae 1-20 part, Radix Notoginseng 1-20 part, Fructus Trichosanthis 1-20 part, Ramulus Cinnamomi 1-20 part, Radix Paeoniae Alba 1-20 part, Semen Plantaginis 1-20 part, Ramulus Uncariae Cum Uncis 1-20 part, Rhizoma Gastrodiae 1-20 part, Flos Rosae Rugosae 1-20 part, Radix Bupleuri 1-20 part, Rhizoma Curcumae Longae 1-20 part, Bulbus Allii Macrostemonis 1-20 part, Radix Rehmanniae Preparata 1-20 part, Pheretima 1-20 part, Caulis Spatholobi 1-20 part, Semen Persicae 1-20 part, Radix Cynanchi Paniculati 1-20 part, Radix Rhodiolae 1-20 part, Radix Puerariae 1-20 part, Rhizoma Acori Graminei 1-20 part, Rhizoma Pinelliae 1-20 part, Flos Lonicerae 1-20 part, Flos Campsis 1-20 part, Radix Cynanchi Atrati 1-20 part.

3. treat atherosclerotic Chinese medicine preparation according to the one described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:

Herb Gynostemmae Pentaphylli 1-10 part, Radix Glycyrrhizae 1-10 part, Poria 1-10 part, Fructus Lycii 1-10 part, Herba Leonuri 1-10 part, Radix Salviae Miltiorrhizae 1-10 part, Rhizoma Chuanxiong 1-10 part, Semen Ziziphi Spinosae 1-10 part, Rhizoma Alismatis 1-10 part, Semen Cassiae 1-10 part, Radix Platycodonis 1-10 part, Herba Menthae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Rhizoma Coptidis 1-10 part, Radix Astragali 1-10 part, Spica Prunellae 1-10 part, Herba Houttuyniae 1-10 part, Radix Notoginseng 1-10 part, Fructus Trichosanthis 1-10 part, Ramulus Cinnamomi 1-10 part, Radix Paeoniae Alba 1-10 part, Semen Plantaginis 1-10 part, Ramulus Uncariae Cum Uncis 1-10 part, Rhizoma Gastrodiae 1-10 part, Flos Rosae Rugosae 1-10 part, Radix Bupleuri 1-10 part, Rhizoma Curcumae Longae 1-10 part, Bulbus Allii Macrostemonis 1-10 part, Radix Rehmanniae Preparata 1-10 part, Pheretima 1-10 part, Caulis Spatholobi 1-10 part, Semen Persicae 1-10 part, Radix Cynanchi Paniculati 1-10 part, Radix Rhodiolae 1-10 part, Radix Puerariae 1-10 part, Rhizoma Acori Graminei 1-10 part, Rhizoma Pinelliae 1-10 part, Flos Lonicerae 1-10 part, Flos Campsis 1-10 part, Radix Cynanchi Atrati 1-10 part.

4. the one according to claims 1 to 3 treats atherosclerotic Chinese medicine preparation, it is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster or syrup.

5. a kind of preparation method for the treatment of atherosclerotic Chinese medicine preparation according to Claims 1-4, is characterized in that: described preparation formulation is oral solutions, comprising of its preparation method:

6. a kind of preparation method for the treatment of atherosclerotic Chinese medicine preparation according to claim 5, is characterized in that: in described step a, gets raw material and adds in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-180 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.。

7. a kind of preparation method for the treatment of atherosclerotic Chinese medicine preparation according to claim 5, it is characterized in that: in described step b, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, and each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.10 extractum, heating be concentrated into paste, stand for standby use, becomes component 2.

8. a kind of preparation method for the treatment of atherosclerotic Chinese medicine preparation according to claim 5, it is characterized in that: in described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, add dextrin, then vacuum canning sealing and get final product, directly drink during use.

9. a preparation method for the atherosclerotic Chinese medicine preparation of the treatment as described in claim 1 to 8, is characterized in that, described preparation formulation is capsule, comprising of its preparation method:

A. described raw material is put into pulverizer grinding and sieving;

10. a preparation method for the atherosclerotic Chinese medicine preparation of the treatment as described in claim 1 to 9, is characterized in that, the dosage form of described endo-medicine is pill, and its preparation process comprises:

B. unsifted coarse powder is soaked in ethanol and extract 2 times;