CN101485867B - Chinese medicinal composition for treating varix and preparation method thereof - Google Patents
Chinese medicinal composition for treating varix and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating varicose vein and a preparation method thereof. The traditional Chinese medicine composition for treating varicose vein comprises the following various components in portion by weight: 10 to 20 portions of Salvia miltiorrhiza, 10 to 20 portions of Rhizoma Zedoariae, 10 to 20 portions of Achyranthes bidentata, 10 to 20 portions of Chinese thorowax roots, 10 to 20 portions of oysters, 10 to 20 portions of Astragalus membranaceus, 10 to 20 portions of leeches, 10 to 20 portions of motherwort, 10 to 20 portions of Chuanxiong rhizome, 10 to 20 portions of frankincense, 10 to 20 portions of pseudo-ginseng, 10 to 20 portions of Curcuma aromatica, 10 to 20 portions of Tuber of Dwarf Lilytur, 10 to 20 portions of Dangshen, 10 to 20 portions of Chinese dodder seeds and 10 to 20 portions of dipsacus saponin. The traditional Chinese medicine composition has the efficacies of warming yang and replenishing qi, enriching, cooling and activating the blood, and dissolving stasis and toxic materials and reducing swelling, mainly treats varicose vein caused by stagnation of arteries and veins, is safe, easy and convenient to use, is painless and nontoxic, has no anaphylactic reaction, has long medicine effect time and low cost, and is an ideal traditional Chinese medicine for treating varicose vein.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, cirsoid Chinese medicine composition of particularly a kind of treatment and preparation method thereof.
Background technology
Varicosis is a kind of common disease.It easily betides crowd above middle age, has a strong impact on people's work capacity after ill, does not also have specific method to effect a radical cure this disease at present.General treatment often adopts the doctor trained in Western medicine method, and the lighter uses injection of sclerosing agent, and weight person can only treat with the method for operation, but therapeutic effect is all undesirable.Injection of sclerosing agent easily causes venous thrombosis, thereby brings out local ulcer and form ecthyma; Operative treatment easily causes lower limb circulatory disturbance, produces to suffer from the limb edema, and recurrence easily.
Motherland's medical science thinks that the varicosis cause of disease has following 2 points: congenital wall of vein or valve weakness.This kind situation makes wall of vein be easy to expansion, and the valve of near-end produces inadequacy, makes backflow of blood.Backflow of blood has just destroyed the far-end valve gradually, produces varicosis finally, and this is a performance of whole body connective tissue weakness, so the patient often has diseases such as hemorrhoid, hernia simultaneously, and family history is often arranged; Occupational factor, the person that generally often do not stand often has varicose veins of the lower extremity in various degree, especially to be engaged in labourer that lasting heavy burden stands for seeing more.Owing to often take orthostatic body position, movable less, the chance that lower limb muscles shrinks reduces, and influence venous blood and refluxes, and makes increased pressure, venectasia in the veins of lower extremity, and valve also thereby produce inadequacy, formation varicosis.In addition, intraperitoneal swell thing, gravid uterus etc. are because the Intraabdominal vein of compressing also can make the formation of varicose veins of the lower extremity.
Treatment varicosis adopts operative therapy more at present, promptly strips off art as veins of lower extremity.If operation can not all be stripped off the vein of varicose, the intravenous of the varicose that stays can injection of sclerosing agent, makes wall of vein produce aseptic inflammation, wall is adhered mutually, no longer varicose.Through clinical practice for many years, also can recur after many patient's operations, uncertain therapeutic efficacy is cut, and repeatedly operation also fails to cure.Modus operandi not only has certain misery to patient, and expense is higher, and cure rate is very low.Pharmacotherapy does not also have the preferable medicine of effect at present, for the traditional Chinese medical science, how to control with heat clearing and damp drying in the past, and the treatment of ignored removing heat from blood, invigorate blood circulation, detoxifying, so therapeutic effect is relatively poor.
Summary of the invention
Technical problem to be solved by this invention is, cirsoid Chinese medicine composition of a kind of treatment and preparation method thereof is provided, adopt rational compatibility, give full play to the effect of the Chinese medicine of respectively distinguishing the flavor of, have effects such as removing damp-heat, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and cooling blood, it is remarkable to be used for the treatment of the varicosis effect, and preparation technology is simple and practical.
For solving the problems of the technologies described above, the invention provides the cirsoid Chinese medicine composition of a kind of treatment, the various components that comprise the following portions by weight ratio: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Achyranthis Bidentataes, 10～20 parts of Radix Bupleuri, 10～20 parts of Concha Ostreaes, 10～20 parts of the Radixs Astragali, 10～20 parts of Hirudos, 10～20 parts of Herba Leonuris, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Olibanums, 10～20 parts of Radix Notoginseng, 10～20 parts of Radix Curcumaes, 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Codonopsis, 10～20 parts of Semen Cuscutae, 10～20 parts of Radix Dipsacis.
The cirsoid Chinese medicine composition of described treatment can preferably include the various components of following portions by weight ratio: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Achyranthis Bidentataes, 10～15 parts of Radix Bupleuri, 10～15 parts of Concha Ostreaes, 15～20 parts of the Radixs Astragali, 10～15 parts of Hirudos, 15～20 parts of Herba Leonuris, 15～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Olibanums, 10～15 parts of Radix Notoginseng, 10～15 parts of Radix Curcumaes, 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Codonopsis, 10～20 parts of Semen Cuscutae, 10～20 parts of Radix Dipsacis.
The cirsoid Chinese medicine composition of described treatment can also preferably include the various components of following portions by weight ratio: 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Rhizoma Curcumae, 15～20 parts of Radix Achyranthis Bidentataes, 15～20 parts of Radix Bupleuri, 15～20 parts of Concha Ostreaes, 15～20 parts of the Radixs Astragali, 10～15 parts of Hirudos, 10～15 parts of Herba Leonuris, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Olibanums, 10～15 parts of Radix Notoginseng, 10～15 parts of Radix Curcumaes, 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Codonopsis, 10～15 parts of Semen Cuscutae, 10～15 parts of Radix Dipsacis.
Described Chinese medicine composition dosage form can be medical herbs decoction, powder, granule, colloid or syrup.
The occupation mode of described Chinese medicine composition can be for orally using.
Described Chinese medicine composition dosage form can be powder, the occupation mode of described powder can be for orally using, its instructions of taking can for: drink boiled water 60～200ml before taking earlier, after boiled water 10～20 gram is heated to 60～80 ℃, described powder 30～90 grams are put into the boiled water of described heating, after stirring, decoction being taken warmly.
For solving the problems of the technologies described above, the present invention also provides the preparation method of the cirsoid Chinese medicine composition of a kind of described treatment, and described Chinese medicine composition dosage form is a powder, and its preparation can be carried out according to the following steps:
(1) 1/2～3/4 independent respectively oven dry with above-mentioned raw materials is crushed to 110～140 order fine powders, and mix homogeneously is standby;
(2) remaining 1/2～1/4 raw material pulverizing to 40～60 order coarse powder inputs are decocted in the container, decoct by weight 1: 1.5～1: 2.5 with water and pour containers for future use into 2～4 times;
(3) supernatant after above-mentioned decoction liquor is left standstill merges, and is concentrated into 1/2～3/4 of amalgamation liquid volume;
(4) above-mentioned spissated decoction liquor is sprayed on the prepared fine powder of step 1 equably;
(5) with above-mentioned fine powder 20～50 ℃ dry 24 hours down, then 65～80 ℃ down heating promptly made powder in 20～40 minutes.
Decocting time can be 10～30 minutes in the described step (2).
In the described step (5), 20～40 minutes step of 65～80 ℃ of following heating is triplicate continuously, is used for further intermittently low temperature sterilization.
Described method may further include the germ-resistant step of fine powder ultra-vioket radiation that step (5) makes.
Chinese medicine composition of the present invention has warming YANG and invigorating QI, the removing heat from blood and promoting blood circulation of enriching blood, and the effect of blood stasis dispelling poison holding detumescence cures mainly because of the varicosis due to the venation that stagnates, and forms diseases such as blood stasis or lump.Chinese medicine composition of the present invention is safe in utilization, the irritated reaction of no pain, avirulence, nothing, and effective drug duration is long, and easy to use, easy row, cost are low, are the cirsoid Chinese medicine medicines of comparatively ideal treatment.
The specific embodiment
Chinese medicine of the present invention shows that through clinical use result following advantage is arranged:
The Radix Salviae Miltiorrhizae hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." Bencao Jingshu ": Radix Salviae Miltiorrhizae, " herbal classic " bitter in the mouth is slightly cold; Tao Yun is hot in nature nontoxic, sees its main trusted subordinate's pathogen, and borborygmus are faint, and cold and heat gather as leaking water, and broken disease is removed abdominal mass, then like the luxuriant and rich with fragrance medicine of trembling with fear; End stuffy sensation with restlessness, QI invigorating, and " not Lu " nourish blood, and removes trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness, exorcising stays heat, obeys sharp people for a long time, again the medicine of a warm nature by no means; When being the flat tepor of bitter in the mouth.Start with, lack enough the moon, meridian of Foot-JUE YIN.Have a guilty conscience pathogen visitor then is the stuffy sensation with restlessness stagnation of QI, then becomes obstinate disease for a long time; Deficiency of the liver then heat very humorously, liver man coagulation of QI-blood is a lump in the abdomen then, cold and heat gather; Suffer from a deficiency of the kidney and cold-damp evil visitor stiffness along the spinal column then, foot numbness; Go into three warps and remove institute's hardship, all cards that then comes up are from removing.Hardship can be let out, and temperature can be loose, so main again borborygmus are faint as leaking water.Obey sharp people's QI invigorating for a long time, that nourishes blood tests also.
Rhizoma Curcumae suffering, hardship, temperature.Return liver, spleen channel.The removing blood stasis promoting the circulation of QI to relieve pain, effect is similar to rhizoma sparganic, but warm concerted effort is bigger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.The removing food stagnancy eliminating stagnation, the pain relieving of circulation of qi promoting removing food stagnancy is used for eating accumulation, the breast abdominal distention is vexed has a pain.Removing blood stasis, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.Promoting the circulation of QI to relieve pain are suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.
Radix Achyranthis Bidentatae is flat, bitter in the mouth, acid.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.Be used for that soreness of waist and knee joint, muscles and bones are unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
The Radix Bupleuri hardship is slightly cold.Return liver, gallbladder meridian.Reconciling superficies and interior, soothing the liver, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Concha Ostreae becomes, and is slightly cold.Return liver, gallbladder, kidney channel.Tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.Be used for the palpitation with fear insomnia, vertigo and tinnitus, scrofula sucutaneous nodule, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid.The Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.Be used for spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Radix Astragali slightly warm in nature, sweet in the mouth has the effect of invigorating QI to consolidate the body surface resistance, hidroschesis detoxification, granulation promoting, diuresis, detumescent.It is weak to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.The Radix Astragali is based on tonify deficiency, be usually used in asthenia with the passing of time, low, the thready pulse without strength person of speech.Radix Astragali tool and mending and oiliness characteristics is with Radix Codonopsis compatibility better effects if then.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease.No matter from Chinese traditional treatment, or modern medicine observes, and the Radix Astragali all is good simply medicines.So, the custom that " winter is got the food that the Radix Astragali is made into nourishing and fit keeping function " just arranged from ancient times among the people.
It is bitter, flat, poisonous that Hirudo becomes.Stimulate the menstrual flow the removing blood stasis with potent drugs detumescence.Diseases such as menstruation apolipsis, lump in the abdomen stomachache, blood-retention, traumatic blood stasis are had a pain, carbuncle erysipelas.Removing blood stasis, removing blood stasis stimulates the menstrual flow.Control blood-retention, lump in the abdomen gathers, women's amenorrhea, and blood stasis becomes consumptive disease, and injury from falling down, order be pain also, nebula." herbal classic ": " main by closing stagnant blood, blood stasis, the moon, the removing blood stasis abdominal mass is gathered, loss of fecundity, dredging water passages.It is swollen that " supplement to the Herbal: " people suffers from red white trip rash and carbuncle poison, get ten surplus a piece order eat disease place, the bark fetching meat that wrinkles is white, also poor invariably." the amplification on Canon of Materia Medica: " folding that cures the wound.″
Herba Leonuri acrid in the mouth hardship, cold.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.The treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, the carbuncle skin infection at hematuria.Herba Leonuri contains various trace elements.The effect that selenium has the enhance immunity cell viability, relaxes the generation of atherosclerosis and improve human body defence function of diseases system; Manganese can antioxidation, the hypertrophy of anti-aging, resisting fatigue and anticancer.Relevant report points out that the part trace element that contains in the Herba Leonuri has tangible vessel softening effect.
The Rhizoma Chuanxiong suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic ": " main apoplexy is gone into the brain headache, arthralgia due to cold, the clonic spasm of the muscle emergency, the gold wound, married woman's blood closes loss of fecundity." " not Lu ": " removes in the brain cold moving, and urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, the soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." " property of medicine opinion ": " controls waist foot weakness, hemiplegia, and main afterbirth does not go out, and controls cold type of pain in the abdomen." " Japan hanako materia medica ": " controls a wind cutting, all gas, and all strains, all blood are mended five kinds of over strain, and strengthening bone and muscle is transferred many arteries and veins, and broken crux stagnated blood is supported fresh blood, puts on flesh, and serious epistaxis is spitted blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, the scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood.″
The Olibanum regulating QI is invigorated blood circulation, and pain relieving chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": " it be swollen to treat the edema due to wind pathogen poison, removes bad odor." " treat the wind addiction? the poison of itching." supplement to the Herbal: " and treat deaf, the apoplexy locked mouth, married woman's vim and vigour can be sent out wine, manage air-cooledly, only is large intestine let out?, treat all skin ulcers and make internal diabetes." " Japan hanako materia medica ": " end cholera, cardiac and abdominal pain.The soft extracts pain relieving is put on flesh." " pearl sac ": " fixed all warps are pain." " detailed outline ": " and all poison of eliminating carbuncle cellulitis, the heart is protected in the Tuoli, and muscle is stretched in the analgesic therapy of invigorating blood circulation, and controls married woman's difficult labour, and folding is hindered." " key medicine is divided agent ": " dysentery with red and white feces more than person that suffers from abdominal pain adds Olibanum and imitates invariably.”
The Radix Notoginseng sweet and slightly bitter taste, warm in nature, return liver, stomach warp.But giving birth to hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, is the YUNNAN BAIYAO main component.Have good hemostasia effect, significant hemopoietic function; Can tighten and improve the arteria coronaria microcirculation, expand Radix Notoginseng and be used as medicine with a long historyly, act on and peculiarly be considered as treasured in the medicine, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged by ancient Chinese medicine doctor." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews promptly ending of mashed net for catching birds or fish immediately, and bruise the person promptly dissipate.If when being subjected to cane, clothes one, two money earlier, then the blood centre of punch not should be obeyed it behind the cane especially, and obey also good puerperal.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood ".
Radix Curcumae suffering, hardship, cold.Return liver, the heart, lung meridian.Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.
Radix Ophiopogonis, sweet, little hardship was slightly cold.GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Relieving restlessness clears away heart-fire: be suitable for the card that interior-heat is disturbed the heart, the epidemic febrile disease pathogenic heat are joined the army, fever aggravated at night, dysphoria; Heat impairing vital QI the moon, restlessness and thirst, the tired person of sweating body; Insufficiency of heart-YIN, dysphoria and insomnia, the few tongue person of red tongue.Nourishing YIN and moistening the lung: cure mainly lung-dryness syndrome due to deficiency of YIN, dry cough, cough caused by dryness, cards such as consumptive fever hemoptysis.Reinforcing stomach reg fluid: be apt to control deficiency of stomach-Yin, dry tongue is thirsty, the indigestion and loss of appetite not hungry card that waits.In addition, the also available deficiency of YIN dryness of the intestine of controlling, constipation person.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.
The Radix Codonopsis invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst.Be used for deficiency of vital energy deficiency, fatigue and weakness, dyspnea with rapid breath, insufficiency of the spleen lack of appetite, the edema of the face, chronic diarrhea proctoptosis.This product is clinical Qi-tonifying drug commonly used, and the function invigorating the spleen to benefit the lung is imitated person of modern times's ginseng and for a little less than, is applicable to the various deficiency of vital energy deficiency persons, compatibility application such as the normal and Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae; The disease of the deficiency of both QI and blood that causes as blood deficiency and yellow complexion and chronic hemorrhage illness is joined hematonic such as Radix Rehmanniae Preparata, Radix Angelicae Sinensis etc.
The Semen Cuscutae nature and flavor are warm in nature, sweet in the mouth.Nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Being used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen suffers from a deficiency of the kidney and rushes down.Main component glucoside-containing, beta-carotene, gamma carotene, retinoid material etc.The Semen Cuscutae acrid-sweet flavor is flat, but invigorating the liver and kidney, and beneficial marrow is supported the flesh reinforcing YIN-essence, hard muscles and bones, physical strength profiting, fertile strong people.For the early whitening of beard and hair due to following first deficiency, soreness of the waist and knees, teeth such as shake at various diseases curative effect preferably, is the widely used medicine in beauty treatment side." book on Chinese herbal medicine justice " speech: " Herba cuscutae is product on the yin nourishing collateral dredging ... antiperspirant goes face quite, the function of also soft and moist skin.”
Radix Dipsaci hardship, suffering, tepor.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends metrorrhagia.Be used for soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia more, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees more.
Chinese medicine composition dosage form of the present invention can be medical herbs decoction, powder, granule, colloid or syrup.
The occupation mode of powder of the present invention is for orally using, its instructions of taking is: drink boiled water 60～200ml before taking earlier, boiled water 10～20 gram is heated to 60～80 ℃ after, described powder 30～90 grams are put into the boiled water of described heating, after stirring, decoction being taken warmly.
The preparation method of the powder of Chinese medicine composition of the present invention is:
(1) with raw material: Radix Salviae Miltiorrhizae 10kg, Rhizoma Curcumae 10kg, Radix Achyranthis Bidentatae 10kg, Radix Bupleuri 10kg, Concha Ostreae 10kg, Radix Astragali 10kg, Hirudo 10kg, Herba Leonuri 10kg, Rhizoma Chuanxiong 10kg, Olibanum 10kg, Radix Notoginseng 10kg, Radix Curcumae 10kg, Radix Ophiopogonis 10kg, Radix Codonopsis 10kg, Semen Cuscutae 10kg, 1/2～3/4 of Radix Dipsaci 10kg is dried separately respectively and is crushed to 120 order fine powders, and mix homogeneously is standby;
(2) remaining 1/2～1/4 raw material pulverizing to 40～60 order coarse powder inputs are decocted in the container, decoct by weight 1: 1.5～1: 2.5 with water and pour containers for future use into 2～4 times, each decocting time is 10～30 minutes;
(3) supernatant after above-mentioned decoction liquor is left standstill merges, and is concentrated into 1/2～3/4 of amalgamation liquid volume;
(4) above-mentioned spissated decoction liquor is sprayed on the prepared fine powder of step 1 equably;
(5) with above-mentioned fine powder 20～50 ℃ dry 24 hours down, 65～80 ℃ of heating 20～40 minutes down, triplicate is used for further intermittently low temperature sterilization continuously then.Dried fine powder ultra-vioket radiation sterilization 20 minutes.
Chinese medicine composition of the present invention induces the effect of rabbit extracorporeal platelet aggregation as follows to adenosine diphosphate (ADP):
The healthy male rabbit of experiment, the fixedly separated common carotid artery in 12h layback position inserts the plastic cement pipe of own silication on an empty stomach.In the common carotid artery blood-letting, with the anticoagulant in 3: 1 of 3.8% sodium citrate,, be platelet rich plasma (PRP) with the centrifugal 10min of 1000rpm, be platelet poor plasma (PPP) with the centrifugal 20min of 2000rpm in addition.Delivery tube adds Chinese medicine composition decoction 0.1ml of the present invention, control tube adding distil water 0.1ml, and each pipe adds PRP0.8ml, and adenosine diphosphate (ADP) (ADP) 0.1ml (equal 011mg, Germany produces) measures it with BS2631 type platelet aggregation instrument and assembles curve.Each dosage is respectively done 10 arms (10 rabbits), and the gathering curve of describing according to the gathering instrument calculates the suppression ratio of Chinese medicine composition decoction of the present invention to platelet aggregation with following formula:
Suppression ratio=(control tube is assembled amplitude-delivery tube and assembled amplitude)/control tube is assembled amplitude * 100
The preparation method of the cirsoid decoction of treatment is in the present embodiment:
Radix Salviae Miltiorrhizae 10g, Rhizoma Curcumae 10g, Radix Achyranthis Bidentatae 10g, Radix Bupleuri 10g, Concha Ostreae 10g, Radix Astragali 15g, Hirudo 10g, Herba Leonuri 15g, Rhizoma Chuanxiong 15g, Olibanum 10g, Radix Notoginseng 10g, Radix Curcumae 10g, Radix Ophiopogonis 10g, Radix Codonopsis 10g, Semen Cuscutae 10g, Radix Dipsaci 10g, decocting 40 minutes.
Result of the test sees Table 1.See that from table 1 decoction of the present invention has good inhibitory effect to the inductive extracorporeal platelet aggregation of ADP, dosage is relevant with effect.
Table 1 couple ADP induces the effect (n=10 x+s) of extracorporeal platelet aggregation
Decoction of the present invention is to the effect of rat experimental thrombosis, fibrinolysis and clotting time
In order to make experimental result not be subjected to effect of estrogen, male white rat is all adopted in this experiment, body weight 306 ± 27g is divided into three groups at random, every group of 10 rat, decoction dosage of the present invention is two groups of 165mg/kg and 500mg/kg, and matched group is given the water with equal volume, every day gastric infusion once, 7d gets hematometry fibrinolysis time and indexs such as clotting time and experimental thrombosis at 8d altogether.It is as follows to have operation and result:
To the Fibrinolytic effect of rat
Experiment is got blood 1ml with the rat of the 7d that takes medicine, adds 3.8% sodium citrate 0.2ml, and mixing is with the centrifugal 10min of 3000rpm, and separated plasma is got blood plasma 0.5ml, places in the small test tube, in 37 ℃ of water-baths
Adding thrombin 0.1ml (is equivalent to 10u, Sigma) makes the clotting of plasma, observe the situation of once dissolving every 1h, and write down dissolution time.
Therefore the matched group rat blood plasma of this experiment pressed 24h and calculated until also not dissolving of 24h when statistics, experimental result sees Table 2.
Table 2 decoction of the present invention is to fibrinolysis (n=10 x+s)
Can find out that from table 2 decoction of the present invention can make fibrin shorten dissolution time very significantly, illustrate that oral administration can promote fibrinolysis in the decoction body of the present invention, relatively act on highly significant with matched group.
Decoction of the present invention is to the influence of rat clotting time
Get the rat of the 7d that takes medicine, measure clotting time with slide method.Cutting off the tail tip flows out blood automatically, wipe the First Blood away with clean cotton ball, accessing effusive one with the microscope slide that cleans bleeds greatly, pick up counting with stopwatch immediately, provoke blood on the slide with dry syringe needle, see till the fiber protein yarn appearance, flowing out to the time that fiber protein yarn occurs from blood is clotting time, and detailed results sees Table 3.
Table 3 decoction of the present invention is to the effect of rat clotting time (n=10 x+s)
Table 3 has shown the clotting time not influence of decoction of the present invention to rat, and the clotting time of three treated animals is basic identical.
Decoction of the present invention is to the effect of rat experimental thrombosis
With the rat of gastric infusion 7d, pentobarbital sodium 50mg/kg intraperitoneal injection of anesthesia, cut skin of neck, separate trachea, common carotid artery, behind the external jugular vein, insert tracheal intubation, common carotid artery and outside make one " bypass " with the silication medical plastic pipe of internal diameter 1.5mm between the common carotid artery, put the #4 operation silk thread of a long 6.5cm in the middle of the bypass, inject the open blood flow 15min of heparin solution 50 μ g/kg from bypass, silk thread in the bypass is taken out, weigh at precision torsion balance, the silk thread in the thrombosis is taken out weigh again, calculate the net weight of thrombosis.Experimental result sees Table 4.
Table 4 decoction of the present invention is to the effect of rat experiment thrombosis (n=10 x+s)
From of be formed with the very obvious suppression effect of table 4 explanation decoction of the present invention to the rat experimental thrombosis.Decoction of the present invention can resist ADP induced platelet aggregation preferably.In the pipe drug level be 4,6, during 8mg, suppression ratio is 58%, 77%, 83%, dosage and effect are corresponding.Rat is irritated stomach and give decoction 165mg/kg of the present invention and 500mg/kg dosage every day, behind the 7d that takes medicine altogether, can shorten fibrinolysis time very significantly.The obviously formation of antagonism rat experimental thrombosis.Not influence of clotting time to rat.
Acute toxicity testing:
The oral maximum dosage-feeding of the mice of Chinese medicine composition of the present invention is 178g crude drug/kg,, calculate by kg body weight, be equivalent to 987 times of Coming-of-Age Day consumption 11.2g, press body surface area and calculate, be equivalent to 153 times; It is 38.369 crude drugs/kg that intraperitoneal administration records its LD50, its 95% credible 33.225～40.375g crude drug/kg that is limited to.Illustrate that Chinese medicine composition oral toxicity of the present invention is low, clinical practice is safer.
Long term toxicity test:
Chinese medicine composition of the present invention to mice by 8.48,18.69 and the 42.17g crude drug/10 weeks of kg continuous use (1.5ml/100g body weight, every day 2 times) and after 4 week of drug withdrawal, the result shows: Chinese medicine composition of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 10 weeks of medication and 4 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Illustrate that toxicity is little after Chinese medicine composition of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.
Varicosis is one of chronic and refractory limb angiopathy, and its etiopathogenesis is not illustrated so far as yet fully, and certain curative effect is treated and obtained to conventional Chinese medicine clinically.The patient who suffers from vascular conditions such as varicosis often causes the hypercoagulability of body under stress state, thrombosed tendency is big, and decoction of the present invention can resist the formation of inductive platelet aggregation of ADP and antagonism rat experimental thrombosis preferably.The rat experimental thrombosis is observed its main component under Electronic Speculum be platelet, closely similar with the mankind's white thrombus (arterial thrombus), and the basic substance that constitutes the vein red thrombus is a fibrin, the material that improves fibrinolytic activity has the effect of anti-red thrombus, decoction of the present invention can promote the fibrinous dissolving of rat very significantly, having pointed out all has effect to red, white two kinds of thrombosis, and mix under the simultaneous situation at red, white thrombus, the meaning of using decoction of the present invention is then bigger.Decoction of the present invention is to the not influence basically of the clotting time of rat, and not have bleeding tendency be corresponding to using behind the decoction of the present invention the patient clinically for this.
Clinical practice of the present invention is to patient's diagnostic classification:
Coomb's test Coomb in the wrong: make the patient flat for sleeping in, will suffer from limb and raise, make blood backflow, emptying in the bent vein that expands, tourniquet is twined at 1/3 place on thigh then, and with pointing compressing small saphenous vein near-end, allows the patient stand again.If decontrol tourniquet, not loosen finger after, the vein of emptying is full of again immediately fully, this shows the great saphenous vein valvuar insufflciency; If only loosen finger, do not decontrol tourniquet, the vein of emptying also is full of immediately fully, then shows the small saphenous vein valvuar insufflciency; If neither decontrol tourniquet, also do not loosen finger, and the vein of emptying was full of in half a minute, then show shallow, organize communicans valvuar insufflciency between vein deeply.
The Bai Erdeshi coomb's test Coomb: allow the patient stand, push down great saphenous vein at thigh root with tourniquet, the vein of varicose is full of obviously, allows the patient firmly stretch the portion of bending knee 10-20 time then.If the vein of varicose disappears, or its full level alleviates, and also do not have the lower limb sense of expanding, and this illustrates that shallow group of venous blood is directed to dark group of intravenous, shows that also dark group of vein is unobstructed; If the degree that the vein of varicose is full of does not alleviate, or increases the weight of, the sense of lower limb distending pain is also arranged, then showing at dark group intravenous has the existence of obstruction.
Therapeutic Method: press preceding method three times on the one, each 5-10 gram, taking 40 continuously is a course of treatment, generally need treat 1-4 the course of treatment according to the state of an illness, can reach effect preferably.
Curative effect judging standard:
Cure: bent expanding disappears, and subjective symptoms is removed entirely.
Effectively: sx.
Specific embodiment 1: Mrs Zhao, 33 years old, married, varicosis is the several years, two lower limb severe varicosis, the scleroma that the affected part is scorching hot, have a Semen phaseoli radiati size surplus in the of 10 belongs to severe varicosis and with superficial phlebitis.Adopt following prescription:
Radix Salviae Miltiorrhizae 10g, Rhizoma Curcumae 10g, Radix Achyranthis Bidentatae 10g, Radix Bupleuri 10g, Concha Ostreae 10g, Radix Astragali 15g, Hirudo 10g, Herba Leonuri 15g, Rhizoma Chuanxiong 15g, Olibanum 10g, Radix Notoginseng 10g, Radix Curcumae 10g, Radix Ophiopogonis 10g, Radix Codonopsis 10g, Semen Cuscutae 10g, Radix Dipsaci 10g.
Subjective symptoms alleviated after the patient took first course of treatment, and varicose disappeared substantially after 1/3, two course of treatment was eliminated in scleroma.After the 3rd course of treatment, heal entirely, follow up a case by regular visits to and do not see recurrence in 2 years.
Specific embodiment 2: Mr. Wang, the man, 26 years old, unmarried, found left lower limb varicosis before 2 years, after increase the weight of gradually, the inboard severe varicosis of right lower extremity, the affected part is scorching hot, and seven, eight scleromas are arranged, and belongs to the thrombotic varicosis of superficial vein.Adopt following prescription:
Radix Salviae Miltiorrhizae 15g, Rhizoma Curcumae 15g, Radix Achyranthis Bidentatae 15g, Radix Bupleuri 15g, Concha Ostreae 15g, Radix Astragali 15g, Hirudo 10g, Herba Leonuri 10g, Rhizoma Chuanxiong 10g, Olibanum 10g, Radix Notoginseng 10g, Radix Curcumae 10g, Radix Ophiopogonis 10g, Radix Codonopsis 10g, Semen Cuscutae 10g, Radix Dipsaci 10g.
Through taking Chinese medicine of the present invention, after first course of treatment, do not ache at left lower extremity, feel to be clearly better, take second and third course of treatment after varicose disappear, follow up a case by regular visits to 1 year not the recurrence.
From clinical manifestation, in the 122 routine objects of observation, simple property varicosis 32 examples are arranged, with superficial vein thrombosis 65 examples, with superficial phlebitis 25 examples.All patients all produce effect after two course of therapy, effective percentage 100%.In the simple property varicosis patient of 32 examples, after first course of therapy, there are 18 examples to cure, after second course of therapy, there are 8 examples to cure again.65 examples have 19 examples to cure after two course of therapy with among the superficial vein thrombosis patient, have 33 examples to cure after the 3rd course of therapy again.25 examples have 7 examples to cure after two course of therapy with among the superficial phlebitis patient, have 10 examples to cure after the 3rd course of therapy again.Integrate, treatment varicosis sufferer is had very significant effect.
Claims (2)
1. cirsoid Chinese medicine composition of treatment and preparation method thereof is characterized in that, comprises the various material components of following portions by weight ratio:
Radix Salviae Miltiorrhizae 10kg, Rhizoma Curcumae 10kg, Radix Achyranthis Bidentatae 10kg, Radix Bupleuri 10kg, Concha Ostreae 10kg, Radix Astragali 10kg, Hirudo 10kg, Herba Leonuri 10kg, Rhizoma Chuanxiong 10kg, Olibanum 10kg, Radix Notoginseng 10kg, Radix Curcumae 10kg, Radix Ophiopogonis 10kg, Radix Codonopsis 10kg, Semen Cuscutae 10kg, Radix Dipsaci 10kg.
2. a preparation method for the treatment of cirsoid Chinese medicine composition according to claim 1 is characterized in that, described Chinese medicine composition dosage form is a powder, and its preparation is carried out according to the following steps:
(1) 1/2～3/4 independent respectively oven dry with above-mentioned raw materials is crushed to 120 order fine powders, and mix homogeneously is standby;
(2) remaining 1/2～1/4 raw material pulverizing to 40～60 order coarse powder inputs are decocted in the container, decoct by weight 1: 1.5～1: 2.5 with water and pour containers for future use into 2～4 times, each decocting time is 10～30 minutes;
(3) supernatant after above-mentioned decoction liquor is left standstill merges, and is concentrated into 1/2～3/4 of amalgamation liquid volume;
(4) above-mentioned spissated decoction liquor is sprayed on the prepared fine powder of step 1 equably;
(5) with above-mentioned fine powder 20～50 ℃ dry 24 hours down, 65～80 ℃ of heating 20～40 minutes down, triplicate is used for further intermittently low temperature sterilization continuously then.Dried fine powder ultra-vioket radiation sterilization 20 minutes.
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| CN104306532A (en) * | 2014-09-09 | 2015-01-28 | 宋永花 | Traditional Chinese medicine used for treating varicose veins of lower limbs |
| CN104435485A (en) * | 2014-12-08 | 2015-03-25 | 广东聚智诚科技有限公司 | Traditional Chinese medicine composition for treating varicose vein of lower limb and preparation method thereof |
| CN104800684A (en) * | 2015-04-30 | 2015-07-29 | 臧孝国 | Traditional Chinese medicine composition for treating varicosity |
| CN106177303A (en) * | 2016-07-21 | 2016-12-07 | 盛存见 | One treats cirsoid medicine and preparation method thereof |
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| CN1078643A (en) * | 1993-04-28 | 1993-11-24 | 肖广权 | Alcoholic tonic for prevention of senility |
| CN1257722A (en) * | 1998-12-24 | 2000-06-28 | 赵徕淋 | Medicinal oil for dredging channels and collaterals of heart and brain and its preparing process |
| CN1398624A (en) * | 2002-08-01 | 2003-02-26 | 李正武 | Chinese medicine prepn for treating varicose vein |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1078643A (en) * | 1993-04-28 | 1993-11-24 | 肖广权 | Alcoholic tonic for prevention of senility |
| CN1257722A (en) * | 1998-12-24 | 2000-06-28 | 赵徕淋 | Medicinal oil for dredging channels and collaterals of heart and brain and its preparing process |
| CN1398624A (en) * | 2002-08-01 | 2003-02-26 | 李正武 | Chinese medicine prepn for treating varicose vein |
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