CN104069305A - Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating chronic pelvic inflammation. The medicine is prepared from the following main raw materials by weight: 9g to 11g of tangerine seeds, 8g to 12g of lychee seeds, 9g to 12g of fructus foeniculi, 8g to 11g of fenugreek, 9g to 11g of rhizoma corydalis, 8g to 12g of trogopterus dung, 6g to 12g of angelica sinensis, 8g to 11g of (processed) cyperus rotundus, 9g to 11g of pericarpium citri reticulatae viride, 6g to 12g of caulis spatholobi, 3g to 9g of white paeony root, 10g to 25g of astragalus membranaceus, 6g to 15g of ligusticum wallichii and 5g to 12g of pulp of dogwood fruit. The medicine is prepared by adopting a unique formula and a unique process of pure natural Chinese herbal medicines in a refining manner via clinical researches for years on the basis of summarization of previous experiences. The natural plant medicines are taken as raw materials, so that all components of the medicine conform to the regulations of the medicine law. Thus, the medicine is used for treating the chronic pelvic inflammation under the synthetic actions of all medicine materials. The medicine is a pure traditional Chinese medicine preparation which is prepared according to the theory of the traditional Chinese medicine, is reasonable in medicine selection and advanced in dosage form, and has an obvious effect for treating the chronic pelvic inflammation.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of chronic pelvic inflammatory disease and preparation method thereof.
Background technology
Chronic pelvic inflammatory disease refers to female internal genital organs and around connective tissue, pelvic peritoneal chronic inflammatory disease.Normal is not thoroughly treatment of acute pelvic inflammatory disease, and in the situation that patient's body constitution is poor, the course of disease of acute pelvic inflammatory disease can be delayed and outbreak repeatedly, causes chronic pelvic inflammatory disease.But also can be without acute pelvic inflammatory disease disease medical history process, as salpingitis due to chlamydia trachomatis infection.The chronic pelvic inflammatory disease state of an illness is more obstinate, can cause menoxenia, leucorrhoea grow in quantity, waist abdomen pain and infertile etc.
Cause the cause of disease of chronic pelvic inflammatory disease to have a lot.When natural defense function is destroyed, or body's immunity declines, endocrine changes or exogenous pathogenic bacterium are invaded, and also can cause the generation of inflammation.Acute pelvic inflammatory disease is as thoroughly treated, and the course of disease is delayed and chronic pelvic inflammatory disease is occurred, also may be due to adjacent organs inflammation direct extension, and such as appendicitis, peritonitis etc. spread to pelvic cavity, cause the generation of chronic pelvic inflammatory disease.Pathogen is taking Escherichia coli as main, and patient can be without acute pelvic inflammatory disease disease medical history.Part chronic pelvic inflammatory disease is the pathological change that acute pelvic inflammatory disease is left over, and pathogen-free domestic exists.As various operation and invasive inspections that pelvic cavity had to certain infringement such as the dilatation and curettage, hydrotubation, hysterosalpingography, hysteroscopy, artificial abortion, or do not strictly observe aseptic principle, can cause reproductive tract mucosa injury, hemorrhage, downright bad, cause the up infection of pathogen of lower reproductive tract endogenous flora.Pelvic inflammatory disease mostly occurs property active phase women, and the especially first sexual intercourse age is little, have multiple sex partner, sexual intercourse overfrequency and sex partner to have sexually transmitted disease (STD) person.The sexually transmitted disease (STD) of lower reproductive tract, as Diplococcus gonorrhoeae cervicitis, chlamydia cervicitis and bacterial vaginosis can be by being connected of lower reproductive tract and pelvic cavity, and then causes the generation of pelvic inflammation.Owing to carrying out sexual behaviour in menstrual period, use unclean menopad, bath in a tub etc., all can make pathogen invade and cause inflammation.In addition, do not note sexual health care, be negligent of carry out vaginadouche person, the incidence rate of pelvic inflammatory disease is high.The extensive adhesion of pelvic cavity due to PID, fallopian tube damage, fallopian tube defence capability declines, and easily causes subinfection again, and Relapse rate outbreak, causes the acute attack of chronic pelvic inflammatory disease.
The method for the treatment of chronic pelvic inflammatory disease has a lot.Warmly can promote pelvic cavity local blood circulation, improve histotrophic nutrition state, improve metabolism, be beneficial to inflammation and absorb and disappear, coordinate relevant Drug therapy simultaneously, can promote absorption and the utilization of body to medicine.Conventional have shortwave, ultrashort wave, microwave, laser, an ion-transmission (can add various medicines as penicillin, streptomycin etc.) etc.Therapeutic alliances long-term or multiple antibacterials repeatedly there is no significant curative effect sometimes, due to long-term inflammatory stimulus, cause organ adhesion around, and anti-inflammatory drug has been not easy to enter, and causes Relapse rate outbreak.
At present, the medicine for the treatment of chronic pelvic inflammatory disease has a lot, for the problems referred to above, publication number CN1586519A(application number 200410060184.7) Chinese patent literature a kind of Chinese medicine preparation for the treatment of women's chronic pelvic inflammatory disease is disclosed, relate to technical field of Chinese medicines.The composition weight proportion of making the raw material of active ingredient in its preparation is: Herba Duchesneae Indicae 13-23, Herba Hedyotidis Diffusae 5-15, Radix Urenae Lobatae 13-23, Radix Malloti Apelitae 5-15 ， Herba Thlaspis 5-15, Caulis Spatholobi 10-20, Radix Rhodomyrti 13-23.The method for making of active ingredient described in its preparation method is to get all raw materials of making active ingredient to decoct with water, filter, concentrate, add ethanol and filter, reclaim ethanol concentrated making, or the part of first getting Herba Duchesneae Indicae medical material wherein, be ground into fine powder, remaining Herba Duchesneae Indicae and remaining Six-element medical material decoct with water, filter, concentrate, add ethanol and filter, and reclaim ethanol concentrated making.And claim that said preparation is in the time being used for the treatment of women's chronic pelvic inflammatory disease, and the clinical symptoms of relieve chronic pelvic inflammatory disease and improve patient sign more significantly,, subacute pelvic inflammatory disease acute in treatment has remarkable result.But can be found out by its clinical case, this medicine can not effectively maybe can not be cured a big chunk patient, and the therapeutic effect of this medicine is not fine.Publication number CN1517115A(application number 03111747.3) Chinese patent literature the scorching capsule of a kind of Chinese patent medicine for the treatment of chronic pelvic inflammatory disease-woman is disclosed, it is taking Flos Lonicerae, Fructus Forsythiae, Rhizoma Smilacis Glabrae, Cortex Phellodendri, Herba Patriniae, Caulis Sargentodoxae, Herba Hedyotidis Diffusae, Cortex Ailanthi, Rhizoma Dioscoreae Septemlobae, Radix Paeoniae Rubra, Semen Persicae, Rhizoma Curcumae, Radix Salviae Miltiorrhizae as raw material, get above 13 taste medicines and add water to submerge decoction 2 hours, filter, filtering residue repeats to decoct 2 times, and merging filtrate, is condensed into thick paste, dry, be ground into fine powder and incapsulate for subsequent use.The present invention has good inflammation-inhibiting and the effect of the sequela that reduces inflammation, and in the process for the treatment of chronic pelvic inflammatory disease, has good therapeutic effect.Cure mainly female sex organ inflammation, be mainly used in chronic pelvic inflammatory disease, endometritis, adnexitis and inflammation of connective tissue etc.But by its clinical case, the curative effect of this medicine is not fine.Publication number CN103191375A(application number 201310136339.X) Chinese patent literature a kind of Chinese medicine composition for the treatment of chronic pelvic inflammatory disease is disclosed, Herba Patriniae 10-20 part, Herba Taraxaci 15-25 part, Radix Angelicae Sinensis 13-23 part, Caulis Sargentodoxae 25-35 part, Radix Salviae Miltiorrhizae 25-35 part, Fructus Forsythiae 10-20 part, Radix Paeoniae Rubra 10-20 part, Semen Coicis 25-35 part, Rhizoma Sparganii 10-20 part, Rhizoma Curcumae 10-20 part, Herba Lycopi 10-20 part, Spina Gleditsiae 19-29 part, Rhizoma Smilacis Glabrae 15-25 part, Cortex Cinnamomi 3-9 part, Radix Et Rhizoma Rhei 6-12 part, Radix Sophorae Flavescentis 7-17 part.And claim that these drug regimens make each efficacy of drugs produce synergism, make it to there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, stasis-dispelling and pain-killing, effect of promoting diuresis and pus discharge, thus can effectively treat chronic pelvic inflammatory disease.Though this medicament relief of symptoms to a certain extent, effect is not remarkable, unsatisfactory to the curative effect of chronic pelvic inflammatory disease.In addition, Rhizoma Sparganii is stronger with the merit of removing blood stasis, and the property of medicine is high violent, can hinder healthy energy, non-body void person suitable, as stagnant in the body nihility stasis of blood and stasis of blood disease bleeder should not apply Rhizoma Sparganii.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide a kind of Chinese medicine composition that can effectively treat chronic pelvic inflammatory disease, it selects natural plant is raw material, each component meets pharmaceutical control law regulation, utilize the comprehensive function treatment chronic pelvic inflammatory disease of each taste medicine, nontoxic to human body, have no side effect, safe and reliable.Medicine of the present invention is according to theory of Chinese medical science formula, selects medicine reasonable, has removing damp-heat, and effect of blood stasis-eliminating and stagnation-dissipating, has accomplished treating both the principal and secondary aspects of a disease, and treatment chronic pelvic inflammatory disease is had to remarkable result.Another object of the present invention is just to provide the preparation method of the Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for chronic pelvic inflammatory disease, take off the primary raw material of stating weight proportion and be prepared from: Semen Citri Reticulatae 9-11 part, Semen Litchi 8-12 part, Fructus Foeniculi 9-12 part, Semen Trigonellae 8-11 part, Rhizoma Corydalis 9-11 part, Oletum Trogopterori 8-12 part, Radix Angelicae Sinensis 6-12 part, (system) Rhizoma Cyperi 8-11 part, Pericarpium Citri Reticulatae Viride 9-11 part, Caulis Spatholobi 6-12 part, Radix Paeoniae Alba 3-9 part, Radix Astragali 10-25 part, Rhizoma Chuanxiong 6-15 part, Fructus Corni 5-12 part.
Treat a Chinese medicine composition for chronic pelvic inflammatory disease, preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Semen Citri Reticulatae 9-10 part, Semen Litchi 9-11 part, Fructus Foeniculi 10-11 part, Semen Trigonellae 9-10 part, Rhizoma Corydalis 9-10 part, Oletum Trogopterori 9-11 part, Radix Angelicae Sinensis 8-10 part, (system) Rhizoma Cyperi 9-10 part, Pericarpium Citri Reticulatae Viride 9-10 part, Caulis Spatholobi 8-10 part, Radix Paeoniae Alba 5-7 part, Radix Astragali 15-20 part, Rhizoma Chuanxiong 9-12 part, Fructus Corni 7-10 part.
Treat a Chinese medicine composition for chronic pelvic inflammatory disease, the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from: 10 parts of Semen Citri Reticulataes, 10 parts of Semen Litchis, 11 parts of Fructus Foeniculi, 10 parts of Semen Trigonellaes, 10 parts of Rhizoma Corydalis, 10 parts of Oletum Trogopteroris, 9 parts of Radix Angelicae Sinensis, 10 parts of (system) Rhizoma Cyperis, 10 parts, Pericarpium Citri Reticulatae Viride, 9 parts of Caulis Spatholobis, 6 parts of the Radix Paeoniae Albas, 18 parts of the Radixs Astragali, 10 parts of Rhizoma Chuanxiongs, 9 parts of Fructus Corni.
The preparation method of above-mentioned Chinese medicine composition, step is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs mistake 60-80 mesh sieve to pieces;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with rice wine, moistening, is placed in marmite, slow fire heating, and fried dry, taking-up cools;
(3) step (2) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 20-40 minute at a simmer;
(4) add the fine powder of step (1) gained after ceasing fire, slowly stir, filter to get filtrate, leave standstill, get supernatant, be aided with pharmaceutically acceptable carrier package.
According to preparation method recited above: step (1) adds appropriate sucrose (preferably add the sucrose doubly with respect to fine powder quality 0.15-0.25, be more preferably the sucrose adding with respect to 0.2 times of fine powder quality).
According to preparation method recited above: step (2) moistening 3-4 hour (preferably moistening 2.5-3.5 hour, is more preferably moistening 3 hours).
According to preparation method recited above: step (2) slow fire heating 20-40 minute (preferably heat 25-35 minute, be more preferably heating 30 minutes).
According to preparation method recited above: step (3) was soaked the preferred 3-5cm of medical material 2-6cm(, was more preferably 4cm).
According to preparation method recited above: step (4) leaves standstill 1-3 hour (preferably 1.5-2.5 hour, is more preferably 2 hours).
Using method: for making the present invention reach optimum therapeuticing effect, taking after mixing it with water with warm water, take every day 3 times, each serving with 5ml, 15 days is a course for the treatment of.
This Chinese medicine composition is remarkable to chronic pelvic inflammatory disease effect, and containing abundant plant biological active component, the mutual compatibility of component, each component acts on each pathology aspect of pelvic inflammatory disease, and the various pathological changes that entirety is improved pelvic inflammatory disease reach treatment pelvic inflammatory disease object.And we have well antibacterial, antiinflammatory, alleviating pain and detumescence, promoting QI to circulate and dispersing the agglomeration of the pathogens, the effect of activating blood and eliminatng dampness, and can blood circulation promoting, histotrophic nutrition improved, alleviate the symptoms such as tunica mucosa tubae uterinae congestion and edema, be conducive to the dissipation of inflammation, chronic pelvic inflammatory disease is had significant therapeutic effect.The present invention prepares simply, and good absorbing effect is evident in efficacy, has no side effect, safe, is conducive to sufferer and alleviates in time condition of illness.
The pharmacological effect of each crude drug is respectively:
Semen Citri Reticulatae: bitter in the mouth, property is flat.Return liver, kidney channel.For the dry mature seed of rutaceae orange and cultivation thereof.Have and regulate the flow of vital energy, eliminating stagnation, effect of pain relieving.For inguinal hernia, painful and swollen testis, acute mastitis swells and ache.
Semen Litchi: sweet in the mouth, micro-hardship, warm in nature.Return liver, kidney channel.For the dry mature seed of sapindaceous plant Fructus Litchi.There is promoting QI to circulate and dispersing the agglomeration of the pathogens, effect of cold-dispelling pain-relieving.For colic of cold type stomachache, painful and swollen testis.
Fructus Foeniculi: acrid in the mouth, warm in nature.Return liver,kidney,spleen, stomach warp.There is dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach, stimulating appetite, the cold expelling of regulating the flow of vital energy, has the effect in supporing yang road.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, institute's abdominal distention and pain, lack of appetite and vomiting, hydrocele of testis, cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain, hernia pain, painful and swollen testis, stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain.Energy stimulating gastrointestinal neural blood vessel, the secretion of facilitating digestion liquid, increases gastrointestinal peristalsis, gets rid of the gas accumulating, so there is effect of stomach invigorating circulation of qi promoting, gastrointestinal peristalsis sometimes can reduce again after excitement, thereby contributes to alleviate spasm, eases the pain.
Semen Trigonellae: bitter in the mouth, warm in nature.This product is the dry mature seed of leguminous plant Semen Trigonellae.Return kidney channel.Rhizoma et radix valerianae herb can be used as medicine, the kidney warming sun, and lung moistening YIN nourishing, the Wen Han that dispels, has the kidney invigorating wind dispelling, and supporing yang analgesic effect has refreshing people's body and mind, and quiet brain is calmed the nerves, lax neural, relieving fatigue, removing obstruction in the collateral to relieve pain, effect of replenishing kidney-YIN tonifying YANG.Be used for the treatment of sexual impotence spermatorrhea, sore waist and aching in the waist and the back, young married woman's dysmenorrhea, the hernia swelling and hanging down of either of the testes, the illness such as the disturbance of lower legs due to pathogenic cold and dampness.The light climacteric syndrome of Semen Trigonellae You Minus, treatment constipation, dysentery, dyspepsia, controls diabetes, reduces cholesterol, and releive sore throat and cough promote the effects such as breast development and pregnancy period milk production.Modern scientific research confirms the few cholesterol of Semen Trigonellae Hai Neng Gou Minus, controls and treatment diabetes and climacteric syndrome.Semen Trigonellae comprises some native compounds that promote that mammary gland tissue is grown, and some zooperal researchs also prove the effect of the few cholesterol of Ta You Minus.In addition, Semen Trigonellae also has therapeutical effect to type i diabetes.
Rhizoma Corydalis: acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.Have and invigorate blood circulation, promoting the circulation of QI, pain relieving, analgesia, calmness, effect of hypnosis.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.Cure mainly all pains of trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Oletum Trogopterori: sweet in the mouth, warm in nature, nontoxic.Return Liver Channel.There is dredging blood vessel, eliminating stasis to stop pain, promoting blood circulation to remove blood stasis, effect of parch to black hemostasis.For blood-stasis internal-depression, do not return through it hemorrhage, if woman uterine bleeding is through many, the purple polylith of color, stabbing pain of the lower abdomen, trusted subordinate's congestion is had a pain, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis, parch to black is controlled metrostaxis.Traumatic injury is controlled in external, Serpentis, insect bite wound.
Radix Angelicae Sinensis: sweet in the mouth, pungent, micro-hardship, warm in nature, there is strong fragrance.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
(system) Rhizoma Cyperi: acrid in the mouth, micro-hardship, sweet, property is flat.There is depressed liver-energy dispersing and QI regulating, effect of menstruction regulating and pain relieving.For irritability stasis, hypochondriac pain uncomfortable in chest, gastropathy, stomachache, menoxenia, dysmenorrhea.
Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature.Return liver, gallbladder, stomach warp.There is soothing the liver dispelling the stagnated QI; Effect that removing food stagnancyization is stagnant.For the distending pain over the hypochondrium of main stagnation of QI due to depression of the liver, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food, distending pain of the breast, hernia pain, the epigastric distending pain of stagnation of QI due to dyspepsia, and qi depression to blood stasis lump in the abdomen extremely, chronic malaria addiction piece.
Caulis Spatholobi: bitter in the mouth, sweet, warm in nature.Return liver, kidney channel.Have and enrich blood, invigorate blood circulation, effect of dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold in nature.Return liver, spleen channel.There is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen channel.There is invigorating QI to consolidate the body surface resistance, diuresis toxin expelling, effect of evacuation of pus.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, diabetes.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, heart channel.Walk and do not keep, can go loose, the up mountain peak top of reaching; Enter again blood system, the descending sea of blood that reaches.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Fructus Corni: sour in the mouth, puckery, micro-hardship.Return liver, kidney channel.This product is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni.Picking fruit when time of the year when autumn changes into winter, peel reddened, after drying or put in boiling water and slightly to scald with slow fire, in time except removal core, dry.There is liver and kidney tonifying, effect of essence astringing and desertion stemming.Be used for having a dizzy spell, deafness and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, Xian essence spermatorrhea, bleeding not during menses, profuse sweating collapse, woman uterine bleeding, interior-heat is quenched one's thirst, and warming the liver the kidney invigorating, controls senile frequent micturition.
The Chinese medicine composition that the present invention treats chronic pelvic inflammatory disease meets the theory of the traditional Chinese medical science about treatment gynaecopathia.Summing up on the basis of forefathers' experience, go through clinical research for many years, adopt pure natural draft Chinese medicine unique formula and technique to refine and form.We are by antibacterial, antiinflammatory, analgesia, improve the resistance against diseases of self and reach the object of healing, can treat the abdominal pain that chronic pelvic inflammatory disease, endometritis etc. cause, all there is good curative effect for chronic pelvic inflammatory disease, acute pelvic inflammatory disease, cervicitis, colpitis mycotica, infusorian property vaginitis etc., especially evident in efficacy to chronic pelvic inflammatory disease.
specific implementation method
embodiment 1treat a Chinese medicine composition for chronic pelvic inflammatory disease, take off the primary raw material of stating weight proportion and be prepared from (every part of 10g): 9 parts of Semen Citri Reticulataes, 8 parts of Semen Litchis, 9 parts of Fructus Foeniculi, 8 parts of Semen Trigonellaes, 9 parts of Rhizoma Corydalis, 8 parts of Oletum Trogopteroris, 6 parts of Radix Angelicae Sinensis, 8 parts of (system) Rhizoma Cyperis, 9 parts, Pericarpium Citri Reticulatae Viride, 6 parts of Caulis Spatholobis, 3 parts of the Radix Paeoniae Albas, 10 parts of the Radixs Astragali, 6 parts of Rhizoma Chuanxiongs, 5 parts of Fructus Corni.
The Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease, preparation process is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs mistake 60 mesh sieves to pieces;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with rice wine, moistening, is placed in marmite, slow fire heating, and fried dry, taking-up cools;
(3) step (2) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 20 minutes at a simmer;
(4) add the fine powder of step (1) gained after ceasing fire, slowly stir, filter to get filtrate, leave standstill, get supernatant, be aided with pharmaceutically acceptable carrier package.
model case onewu XX, women, 36 years old, unemployed, Wu Jiabao people from town, Jinan City, Shandong Province.More than abnormal vaginal bleeding first quarter moon, examine on March 7th, 2012.Patient's readme, on January 21st, 2012, February 22 started to occur that vagina is hemorrhage on a small quantity, and next day, blood volume did not increase, and vaginal hemorrhage stopped on 1.Patient thinks it is menoxenia, within several days afterwards, have some again the blood of a brown, do ultrasound diagnosis to commune hospital, finish B ultrasonic after doctor say that can not determine is uterine pregnancy, further check B ultrasonic, blood HCG to the People's Hospital of city, making a definite diagnosis is uterine pregnancy, B ultrasonic points out in utero early pregnancy (having no obvious core barrel beats) to prevent miscarriage in hospital one week, and vagina still has hemorrhage on a small quantity, without stomachache, the doctor of the People's Hospital of city is diagnosed as chronic pelvic inflammatory disease, advises its treatment of abandoning preventing miscarriage.Patient started to occur distending pain of the breast before 10 days, a few days ago start to occur feeling sick vomiting.The nearest diet of patient is not good, sleeps not good enough, and defecation is normal.Look, listless, outward appearance is without anemia looks, and figure is well-balanced, and vital sign is steady, and external genitalia is not looked into.The many places inhibition of seeking medical advice is all not good.
Take embodiment 1 gained Chinese medicine composition after 7 days, distending pain of the breast, nausea and vomiting, the symptoms such as menoxenia have had and have significantly alleviated, continue to take embodiment 1 gained Chinese medicine composition and had significant curative effect after 10 days, the various malaise symptoms of self-induction disappear, and go hospital's further consultation, and result chronic pelvic inflammatory disease is fully recovered.Doctor advised CHENNU scholar consolidates continuing to take embodiment 3 gained Chinese medicine composition for one week.So far in the time more than 1 year, do not recur again.
embodiment 2treat a Chinese medicine composition for chronic pelvic inflammatory disease, take off the primary raw material of stating weight proportion and be prepared from (every part of 20g): 11 parts of Semen Citri Reticulataes, 12 parts of Semen Litchis, 12 parts of Fructus Foeniculi, 11 parts of Semen Trigonellaes, 11 parts of Rhizoma Corydalis, 12 parts of Oletum Trogopteroris, 12 parts of Radix Angelicae Sinensis, 11 parts of (system) Rhizoma Cyperis, 11 parts, Pericarpium Citri Reticulatae Viride, 12 parts of Caulis Spatholobis, 9 parts of the Radix Paeoniae Albas, 25 parts of the Radixs Astragali, 15 parts of Rhizoma Chuanxiongs, 12 parts of Fructus Corni.
The Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease, preparation process is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs mistake 60 mesh sieves to pieces;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with rice wine, moistening, is placed in marmite, slow fire heating, and fried dry, taking-up cools;
(3) step (2) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 20 minutes at a simmer;
(4) add the fine powder of step (1) gained after ceasing fire, slowly stir, filter to get filtrate, leave standstill, get supernatant, be aided with pharmaceutically acceptable carrier package.
model case twomerchant XX, female, 28 years old, Hou Ying people from town, Liaocheng of Shandong Province.Before 2 years, there is lower-left stomachache without obvious inducement, for paroxysmal, after morbidity, be once diagnosed as the rear poor effect of " pelvic inflammatory disease " treatment at diformazan examination in hospital, after again in the diagnosis and treatment of local institute of traditional Chinese medicine, consider that " enterospasm " gives oral liquid, pain is slightly alleviated, but just aggravation of pain in several days before and after every menstruation, have to oral analgesic.Until the year before, there is an about lump of 1.0 × 1.0cm at the position of finding the frequent pain of left lower quadrant,, again arrive diformazan hospital therapy, look into stomach wall B ultrasonic without extremely, patient requires operation, considers that lump is that lymph node is again less, so refusal is performed the operation.Patient arrives province front three hospital's row excision again, and does pathology.After excision, pain disappears, until before 3 months, again there is pain, and violent, endurable.When pain, involve whole lower abdomen, without feeling sick, vomitting, without diarrhoea, without frequent micturition, dysurea and gross hematuria.Diet and defecation are normal.Previously without hepatitis, tuberculosis and hereditary medical history.Medicine-less allergy history.Eumenorrhea, before 4 years, once did cesarean, produce a healthy boy.Have a medical check-up: body temperature 36.5 blood pressures 110/70, ordinary circumstance is good, and mucocutaneous without xanthochromia, lymph node is without enlargement.The flat lower abdomen of abdomen has the cicatrix of a 10cm, and left lower quadrant has the cicatrix of an about 3cm.Full abdomen is soft, and left lower quadrant mild tenderness, without rebound tenderness, muscle tonus.Liver spleen does not touch.Borborygmus normal presence, two lower limb are without edema, physiological reflex normal presence.
Take embodiment 2 gained Chinese medicine compositions after 5 days, the symptom of stomachache alleviates to some extent, sees that malaise symptoms alleviates to some extent, continues again to take embodiment 2 gained Chinese medicine composition 10 days, and various malaise symptoms are eased.Patient continues to take embodiment 2 gained Chinese medicine compositions and consolidates over 10 days, and various malaise symptoms all disappear, and patient's self-induction heals entirely.
embodiment 3treat a Chinese medicine composition for chronic pelvic inflammatory disease, take off the primary raw material of stating weight proportion and be prepared from (every part of 30g): 9 parts of Semen Citri Reticulataes, 9 parts of Semen Litchis, 10 parts of Fructus Foeniculi, 9 parts of Semen Trigonellaes, 9 parts of Rhizoma Corydalis, 9 parts of Oletum Trogopteroris, 8 parts of Radix Angelicae Sinensis, 9 parts of (system) Rhizoma Cyperis, 9 parts, Pericarpium Citri Reticulatae Viride, 8 parts of Caulis Spatholobis, 5 parts of the Radix Paeoniae Albas, 15 parts of the Radixs Astragali, 9 parts of Rhizoma Chuanxiongs, 7 parts of Fructus Corni.
The Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease, preparation process is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs mistake 80 mesh sieves to pieces;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with rice wine, moistening, is placed in marmite, slow fire heating, and fried dry, taking-up cools;
(3) step (2) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 40 minutes at a simmer;
(4) add the fine powder of step (1) gained after ceasing fire, slowly stir, filter to get filtrate, leave standstill, get supernatant, be aided with pharmaceutically acceptable carrier package.
embodiment 4treat a Chinese medicine composition for chronic pelvic inflammatory disease, take off the primary raw material of stating weight proportion and be prepared from (every part of 20g): 10 parts of Semen Citri Reticulataes, 11 parts of Semen Litchis, 11 parts of Fructus Foeniculi, 10 parts of Semen Trigonellaes, 10 parts of Rhizoma Corydalis, 11 parts of Oletum Trogopteroris, 10 parts of Radix Angelicae Sinensis, 10 parts of (system) Rhizoma Cyperis, 10 parts, Pericarpium Citri Reticulatae Viride, 10 parts of Caulis Spatholobis, 7 parts of the Radix Paeoniae Albas, 20 parts of the Radixs Astragali, 12 parts of Rhizoma Chuanxiongs, 10 parts of Fructus Corni.
The Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease, preparation process is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs mistake 80 mesh sieves to pieces;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with rice wine, moistening, is placed in marmite, slow fire heating, and fried dry, taking-up cools;
(3) step (2) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 40 minutes at a simmer;
(4) add the fine powder of step (1) gained after ceasing fire, slowly stir, filter to get filtrate, leave standstill, get supernatant, be aided with pharmaceutically acceptable carrier package.
model case threeopen XX, women, 21 years old, Zhang Lu people from market town, Liaocheng of Shandong Province, lower abdominal pain, eumenorrhea, anteversion of uterus.The clinical pelvic inflammatory disease anti-inflammatory treatment of pressing is after one week, and stomachache takes a turn for the better.Check B ultrasonic shows: anteversion of uterus, and palace body echo is owed evenly, and endometrium line is clear, cervix uteri no abnormality seen echo.In pelvic cavity, see a larger Combination enclosed mass echo, inside as seen slightly muddy opaque dark area of fluid is slightly euphotic zone separation, and slightly strong echo is rolled into a ball filling wherein as seen simultaneously, crude and the thickness of its wall is not etc., the visible peplos sample of enclosed mass echo, owe clearly on border, is connected with uterus and bilateral adnexa.Change position and have no obvious movement, the slightly modification of pressure.Its rear wall Echoenhance.Bilateral adnexa entirety echo is crude, and bilateral fallopian tube position echo thickens.Bilateral ovaries profile is bigger, and internal echo inequality all strengthens echo group accompanying sound shadow obvious as seen in a jumble.Hypogastric region intestinal tube wall Echoenhance, is shown in wriggling, has no obvious hydrops echo in intestinal tube.Ultrasonic diagnosis: 1. mixed type enclosed mass in pelvic cavity, inside see separation, in inflammatory mass companion pelvic cavity, first adhesion is considered; 2. bilateral fallopian tube thickens, and inflammation is considered 3. bilaterals (ovary) teratoma, 4. Echogenic bowels, adhesion.
The time of examining is JIUYUE in 2012 13 days.Take embodiment 4 gained Chinese medicine compositions after 7 days, the symptoms such as lower abdomen pendant pain, leucorrhea abnormal have had and have significantly alleviated, and continuing to take embodiment 4 gained Chinese medicine compositions has had significant curative effect after 10 days, the various malaise symptoms disappearances of self-induction, go hospital's further consultation, result chronic pelvic inflammatory disease is fully recovered.Doctor advised Ms Zhang consolidates continuing to take embodiment 4 gained Chinese medicine composition for one week.So far in the time more than 2 years, do not recur again soon,
embodiment 5treat a Chinese medicine composition for chronic pelvic inflammatory disease, take off the primary raw material of stating weight proportion and be prepared from (every part of 20g): 10 parts of Semen Citri Reticulataes, 10 parts of Semen Litchis, 11 parts of Fructus Foeniculi, 10 parts of Semen Trigonellaes, 10 parts of Rhizoma Corydalis, 10 parts of Oletum Trogopteroris, 9 parts of Radix Angelicae Sinensis, 10 parts of (system) Rhizoma Cyperis, 10 parts, Pericarpium Citri Reticulatae Viride, 9 parts of Caulis Spatholobis, 6 parts of the Radix Paeoniae Albas, 18 parts of the Radixs Astragali, 10 parts of Rhizoma Chuanxiongs, 9 parts of Fructus Corni.
The Chinese medicine composition of above-mentioned treatment chronic pelvic inflammatory disease, preparation process is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs to pieces, and the powder of acquisition is crossed to 50-80 mesh sieve, adds subsequently appropriate sucrose, mix homogeneously;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis and the Radix Paeoniae Alba, mix thoroughly with rice vinegar, moistening, puts in marmite, with slow fire heating 30 minutes, fries to aobvious buff, and taking-up cools;
(3) get Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with yellow wine, vexed, put in marmite, by slow fire heating 30 minutes, fried dry, taking-up cools;
(4) step (2)-(3) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 30 minutes at a simmer;
(5) fine powder that adds step (1) to obtain after truce, slowly stirs, and filters to get filtrate, and leaves standstill 2 hours, gets supernatant, is aided with pharmaceutically acceptable carrier package.
experimental examplein order to verify the drug effect of Chinese medicine composition of embodiment 5 gained treatments chronic pelvic inflammatory diseases, we have carried out contrast test.In August, 2010-2012 are accepted patient 300 people because of chronic pelvic inflammatory disease hospitalization for medical treatment year August, are divided at random two groups, all case symptom typical cases, and diagnostic criteria is according to the diagnosis of " obstetrics and gynecology " the 6th edition chronic pelvic inflammatory disease.Be initial patient, all do not take before and after onset antibiotic and similar medicine.To be divided at random observation group and matched group, every group of number is identical, is 150 people.Test 1 week before, carries out Continuous Observation to this crowd, records symptom and variation.Embodiment 5 gained Chinese medicine compositions are taken by observation group, and take night and morning every day, and matched group is taken the tinidazole of antibiotic cephalo three generations and anaerobe resistant simultaneously, taken three times a day.Record symptom, sign remission time, the temperature decline time, medication is carried out gynecologial examination after 2 courses for the treatment of, from the course for the treatment of final day follow up a case by regular visits to 1 year, observe recurrence.Curative effect judging standard: recovery from illness: after taking 52 courses for the treatment of of gained Chinese medicine composition of embodiment, malaise symptoms disappears completely, and gynecologial examination pelvic cavity is without tenderness, and adnexa thickens completely and disappears; Effective: after taking 52 courses for the treatment of of gained Chinese medicine composition of embodiment, symptom and sign is obviously alleviated, and gynecologial examination obviously alleviates before treating; Invalid: after taking 52 courses for the treatment of of gained Chinese medicine composition of embodiment, symptom even has without alleviating the sign or the recurrence that increase the weight of.Wherein, total effective rate comprises effective and healing, within 15 days, is a course for the treatment of.Result is as shown in the table:
Table 1
Table 2
Table 3
efficacy analysis:short term effect comparison: paresthesia alleviateding time, enclosed mass extinction time, the high pyretolysis time of taking the observation group of embodiment 5 gained Chinese medicine compositions are all significantly shorter than the matched group of oral western medicine.Long-term efficacy comparison: observation group has 6 people invalid, wherein 1 people recurrence, for stopping treating recurrence in latter 8 months.And matched group has 42 people invalid, wherein there are 26 people recurrences, stopping after treatment each monthlyly has a recurrence, obviously finds out that the inefficiency of matched group of oral western medicine and relapse rate are apparently higher than the observation group of taking embodiment 5 gained Chinese medicine compositions.As can be seen from Table 2, take the only having 1 people recurrence of embodiment 5 gained Chinese medicine compositions and oral western medicine has 26 people's recurrences, and take the total effective rate of embodiment 5 gained Chinese medicine compositions and cure rate up to 96% and 80%, and the total effective rate of oral western medicine and cure rate only reach respectively 72% and 25.3%.Experiment shows to take compared with the administration group of embodiment 5 gained Chinese medicine compositions and the matched group of oral western medicine, and its curative effect is more remarkable, and cure rate is high and relapse rate is low, really solves patient's slight illness.
In sum, the Chinese medicine composition effect that the present invention treats chronic pelvic inflammatory disease is remarkable, and Most patients symptom after 2 courses for the treatment of of medication is clearly better, and sense of discomfort disappears, comparatively severe patient after medication 2-3 month symptom also can be improved significantly, malaise symptoms disappears.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. a Chinese medicine composition for the treatment of chronic pelvic inflammatory disease, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Semen Citri Reticulatae 9-11 part, Semen Litchi 8-12 part, Fructus Foeniculi 9-12 part, Semen Trigonellae 8-11 part, Rhizoma Corydalis 9-11 part, Oletum Trogopterori 8-12 part, Radix Angelicae Sinensis 6-12 part, (system) Rhizoma Cyperi 8-11 part, Pericarpium Citri Reticulatae Viride 9-11 part, Caulis Spatholobi 6-12 part, Radix Paeoniae Alba 3-9 part, Radix Astragali 10-25 part, Rhizoma Chuanxiong 6-15 part, Fructus Corni 5-12 part.
2. the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Semen Citri Reticulatae 9-10 part, Semen Litchi 9-11 part, Fructus Foeniculi 10-11 part, Semen Trigonellae 9-10 part, Rhizoma Corydalis 9-10 part, Oletum Trogopterori 9-11 part, Radix Angelicae Sinensis 8-10 part, (system) Rhizoma Cyperi 9-10 part, Pericarpium Citri Reticulatae Viride 9-10 part, Caulis Spatholobi 8-10 part, Radix Paeoniae Alba 5-7 part, Radix Astragali 15-20 part, Rhizoma Chuanxiong 9-12 part, Fructus Corni 7-10 part.
3. the Chinese medicine composition for the treatment of chronic pelvic inflammatory disease according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 10 parts of Semen Citri Reticulataes, 10 parts of Semen Litchis, 11 parts of Fructus Foeniculi, 10 parts of Semen Trigonellaes, 10 parts of Rhizoma Corydalis, 10 parts of Oletum Trogopteroris, 9 parts of Radix Angelicae Sinensis, 10 parts of (system) Rhizoma Cyperis, 10 parts, Pericarpium Citri Reticulatae Viride, 9 parts of Caulis Spatholobis, 6 parts of the Radix Paeoniae Albas, 18 parts of the Radixs Astragali, 10 parts of Rhizoma Chuanxiongs, 9 parts of Fructus Corni.
4. according to the preparation method of the Chinese medicine composition of the arbitrary described treatment chronic pelvic inflammatory disease of claim 1-3, it is characterized in that, step is as follows:
(1) Semen Citri Reticulatae, Semen Trigonellae and Semen Litchi are mixed, mix thoroughly with saline, slightly vexed, to put in marmite, slow fire is fried to micro-yellow, in the time having fragrance, takes out and dries, and smashs mistake 60-80 mesh sieve to pieces;
(2) get Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Rhizoma Corydalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Oletum Trogopterori, the Radix Astragali and Radix Angelicae Sinensis, mix thoroughly with rice wine, moistening, is placed in marmite, slow fire heating, and fried dry, taking-up cools;
(3) step (2) gains and Fructus Foeniculi, Caulis Spatholobi, Fructus Corni are joined in marmite, add suitable quantity of water, soaked medical material, intense fire is fried open, 20-40 minute at a simmer;
(4) add the fine powder of step (1) gained after ceasing fire, slowly stir, filter to get filtrate, leave standstill, get supernatant, be aided with pharmaceutically acceptable carrier package.
5. preparation method according to claim 4, is characterized in that: step (1) adds appropriate sucrose (preferably add the sucrose doubly with respect to fine powder quality 0.15-0.25, be more preferably the sucrose adding with respect to 0.2 times of fine powder quality).
6. preparation method according to claim 4, is characterized in that: step (2) moistening 3-4 hour (preferably moistening 2.5-3.5 hour, is more preferably moistening 3 hours).
7. preparation method according to claim 4, is characterized in that: step (2) slow fire heating 20-40 minute (preferably heat 25-35 minute, be more preferably heating 30 minutes).
8. preparation method according to claim 4, is characterized in that: step (3) was soaked the preferred 3-5cm of medical material 2-6cm(, was more preferably 4cm).
9. preparation method according to claim 4, is characterized in that: step (4) leaves standstill 1-3 hour (preferably 1.5-2.5 hour, is more preferably 2 hours).
10. the application of the Chinese medicine composition as described in as arbitrary in claim 1-3 in the time of the medicine of preparation treatment chronic pelvic inflammatory disease.
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| CN106266400A (en) * | 2016-09-10 | 2017-01-04 | 四川金堂海纳生物医药技术研究所 | A kind of endo-medicine treating chronic pelvic inflammatory disease and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105169251A (en) * | 2015-09-15 | 2015-12-23 | 程素芹 | Traditional Chinese medicine preparation for treating chronic pelvic inflammation and preparation method of traditional Chinese medicine preparation |
| CN106266400A (en) * | 2016-09-10 | 2017-01-04 | 四川金堂海纳生物医药技术研究所 | A kind of endo-medicine treating chronic pelvic inflammatory disease and preparation method thereof |
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