CN103007234B - Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation - Google Patents

Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation Download PDF

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CN103007234B
CN103007234B CN201210583276.8A CN201210583276A CN103007234B CN 103007234 B CN103007234 B CN 103007234B CN 201210583276 A CN201210583276 A CN 201210583276A CN 103007234 B CN103007234 B CN 103007234B
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radix
chinese medicine
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liver
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CN103007234A (en
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周少红
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Zhou Shaohong
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Abstract

The invention provides a traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis. The traditional Chinese medicine preparation comprises the following active ingredients in parts by weight: 10-20 parts of motherwort, 10-20 parts of white paeony root, 10-20 parts of raspberry, 10-20 parts of perilla stem, 10-20 parts of angelica, 10-20 parts of dogwood, 10-20 parts of polygala tenuifolia, 10-20 parts of dandelion, 10-20 parts of glossy privet fruit, 10-20 parts of prepared fleece flower root, 10-20 parts of bupleurum, 10-20 parts of shelled cedar seed, 10-20 parts of rhizome of chuanxiong, 10-20 parts of trogopterus dung, 10-20 parts of root of red-rooted salvia, 10-20 parts of fennel, 10-20 parts of rhizoma cyperi, 10-20 parts of poria with hostwood, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of dried ginger and 10-20 parts of cortex albiziae. The traditional Chinese medicine preparation is on the basis of syndrome differentiation and treatment and has good clinical curative effects by taking liver regulating medicines for smoothing the liver, warming the liver, nourishing the liver, removing heat from the liver and the like as well as medicines for invigorating blood circulation and eliminating stasis.

Description

A kind ofly treat endometriosis Chinese medicine preparation causing dysmenorrhea and preparation method thereof
Technical field
The present invention relates to the Chinese medicine containing deriving from plant, animal or mineral component, particularly a kind ofly treating endometriosis Chinese medicine preparation causing dysmenorrhea and preparation method thereof.
Background technology
Endometriosis is common gynecological disease, and main manifestations is that dysmenorrhea Secondary cases Progressive symmetric erythrokeratodermia increases the weight of, and in Women of Childbearing Age, sickness rate can reach 10%, and the endometriosis patients of 71% ~ 87% has chronic pelvic pain.Most scholar thinks, " stagnation of blood stasis uterus, punching times " is the basic pathogenesis of endometriosis dysmenorrhea, and blood circulation promoting and blood stasis dispelling is base therapy principle.But the decoction for the treatment that alone drug for invigorating blood circulation and eliminating stasis is piled up, effect is also unsatisfactory.In conjunction with clinical practice, endometriosis dysmenorrhea and Liver Channel functional disorder in close relations, treat time adopt treat from liver, based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, add soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. respectively at application drug for invigorating blood circulation and eliminating stasis simultaneously and adjust liver medicine, clinically obtain good curative effect.
Dysmenorrhea is that women is modal a kind of sick, and its pathogenic factor mostly is when row, by the impact of various paathogenic factor, makes punching appoint QI-blood circulation smooth, severe patient through stasis in uterus, collaterals of the uterus so that " stagnation of QI and blood may bring about pain "; Or deficient qi and blood, kidney qi loss cause uterus and lose in moistening foster, " not flourish and pain ".Sick position in uterus, punching appoints, with " stagnation of QI and blood may bring about pain " or " not Rong Ze pain " for main pathogenesis, clinical point functional (also known as constitutional) and organic (also known as Secondary cases).Often show stomachache to mostly occur at (1 ~ 2) d before tide, the 1d that passes through reaches peak, and can be paroxysmal spasmodic or distending pain companion bearing down, severe patient can emit to inside lumbosacral region, anus, vagina, stock.Even visible pale complexion, be in a cold sweat, hands and feet coolness etc. is fainted resembles.Also have minority in menses will clean or after clean (1 ~ 2) d begin to feel and suffer from abdominal pain or waist stomachache person.In conjunction with physical examination, generally do not accompany tension of abdominal muscle or rebound tenderness, adolescence or unpregnancy young woman person many function of dominants dysmenorrhea; Child-bearing period or repeatedly have in motherhood history and intrauterine surgical history companion pelvic cavity and have adhesion, enclosed mass, tuberosity or increase thick one, then belong to organic caused by the disease such as pelvic inflammation, endometriosis more.Some patients also shows body of uterus extremely flexing or cervix uteri stenostomy.
" Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " is pointed out: " passages through which vital energy circulates of the sufficient the moon of fainting of liver, arises from the dorsal hairy region of the big toe ... cross external genitals, and to lower abdomen ... the diseases resulting from the disorder of this meridian lumbago with inability of bending forward and backward, husband Hui hernia, married woman's lower abdominal pain, very then dry sensation in the pharynx, dusty face decolours." " Plain Questions lift pain opinion " also point out: " cold visitor in arteries and veins, then blood tears swift pulse, therefore costa sternales and abdomen phase dragging pain less ".Cold coagulation Liver Channel, passages through which vital energy circulates contracture, qi depression to blood stasis is the Etiological pathogenesis causing endometriosis dysmenorrhea.Clinical manifestation as lower abdomen contracture cold type of pain, aversion to cold and cold limbs, pale complexion.Many dispelling cold by warming the meridian medicines, as Fructus Foeniculi, Fructus Evodiae, Cortex Cinnamomi, all enter Liver Channel and reach effect of antalgic.Faint the arteries and veins of the moon, the arteries and veins person of the moon of fainting, hernia and colic lies in liver, the liver failing to maintain the normal flow of QI, the syndrome that depression and stagnation of QI shows.Many because of depressed emotion, or the invasion of unexpected direct stimulation and other pathogenic factor and falling ill.The liver failing to maintain the normal flow of QI, mechanism of qi pent-up, then depressed emotion; Of a specified duration strongly fragrant puzzled, lose its submissive happy property, therefore being irritable and getting angry easily.Production of phlegm due to stagnation of QI, phlegm rising following QI, fights to tie and then sees globus hystericus in pharynx, and accumulating in neck is then goiter, qi disease involving blood, qi depression to blood stasis, disharmony of Chong and Conception Channels, therefore menoxenia or abdominal pain during menstruation.Gas gathers blood agglomeration, with the passing of time becomes Guo abdominal mass to gather.Control suitable dispersing the stagnated live-QI to relieve the stagnation of QI, be equipped with activating QI to eliminate phlegm if desired, the methods such as movable blood soft hard.
Liver controlling conveyance and dispersion, has the function of emotion regulation, syndrome of stagnation of liver qi, general depressed emotion, Liver Channel cross position feeling of distension and oppression pain occur, the breast side of body or few abdominal distention is vexed alters pain, uncomfortable in chest, sighing frequently, depressed emotion irritability, or foreign body in pharynx sense, or cervical region goiter, or the lower lump of the side of body.The visible following symptom of women: 1. what depression of liver-QI caused constrains, worry often causes women to have a headache, agitation, anxious state of mind irritability, distending pain in the chest and hypochondrium, abdominal part distension, endocrine regulation.2. whether whether normal closely related with the catharsis function of liver woman's eumenorrhea is, and irritability is not dredged can cause too short, Hypomenorrhea in menstrual period, intermenstrual bleeding, dizziness during menstruation, be insomnia through row.3. Liver Channel follows row at two sides of body, and Liver Channel arteries and veins runs freely also may not cause cyclomastopathy, the breast nodule even generation of breast carcinoma.4. stagnation of liver-QI causes insomnia, shows as and has difficulty in going to sleep, even if fall asleep also dreaming often and waking easily.Cannot ensure sleep quality, make femininity blood cervical carcinoma with cachexia, pachylosis, face is obscure.Wherein liver depression forming fire type aypnia is many because of angry impairing the liver.
In conjunction with clinical practice, endometriosis dysmenorrhea and Liver Channel functional disorder in close relations, adopting treat from liver when treating, based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adding soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. respectively at application drug for invigorating blood circulation and eliminating stasis simultaneously and adjusting liver medicine, clinically obtain good curative effect, reconcile temperament and interest, relieving dysmenorrhea, dispersing the stagnated live-QI to relieve the stagnation of QI is reasonable selection, generally being free from side effects, is very safe.
Medicine just under study for action comprises leukotriene inhibitors and vasopressin.Randomized control study confirms that starting first three day in dysmenorrhea uses vasopressin can effective relieving dysmenorrhea relative to placebo.Arachidonic acid is the precursor of synthesis of prostaglandins, (comprises the absorption reducing salmon fish, tuna, beans, Semen Sesami, sunflower seed etc., increases the absorption of whole wheat, vegetable and fruit) so low fat diet.Oral vitamin E and B1, magnesium sulfate, fish oil, low fat diet and Chinese medicine Toki-shakuyaku-san (TSS) all can relieving dysmenorrheas, but these sources of evidence are studied in small-scale nonrandomness.Data about exercise are limited, but think that it is effective.Local heat, acupuncture and transcutaneous electrical neural stimulation (TENS).Result of study thinks that blood-activating stasis-removing kind Chinese medicine also may be effectively.The effect of spinal manipulation is still treated to determine further.Traditional Chinese medicine preparation, often can be difficult to Symptomatic medicine, and specific aim is not strong, and therapeutic effect is general; Therefore find safety, effectively, dispersing the stagnated live-QI to relieve the stagnation of QI comprehensively, blood circulation promoting and blood stasis dispelling, relieving dysmenorrhea, be the important topic of pendulum in face of vast medical research worker it
Summary of the invention
Technical problem to be solved by this invention is, the conventional methods of current relieving dysmenorrhea is that oral vitamin E and B1, magnesium sulfate, fish oil, low fat diet and Chinese medicine Toki-shakuyaku-san (TSS) all can relieving dysmenorrheas, but these sources of evidence are studied in small-scale nonrandomness.Endometriosis dysmenorrhea and Liver Channel functional disorder in close relations, treat from liver is adopted when treating, based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, add soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. respectively at application drug for invigorating blood circulation and eliminating stasis simultaneously and adjust liver medicine, clinically obtain good curative effect traditional Chinese medicine preparation, often can be difficult to Symptomatic medicine, and specific aim is not strong, therapeutic effect is general.
For solving these technical barriers, the invention provides and a kind ofly treat the Chinese medicine preparation that endometriosis causes dysmenorrhea, in described Chinese medicine preparation, the parts by weight of various raw material comprise: Herba Leonuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Caulis Perillae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Poria cum Radix Pini 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts.
Described dispersing the stagnated live-QI to relieve the stagnation of QI, the Chinese medicine preparation of relieving dysmenorrhea, in Chinese medicine preparation described in it, the parts by weight of various raw material can be preferably: Herba Leonuri 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Caulis Perillae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Radix Bupleuri 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Poria cum Radix Pini 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts.
Described dispersing the stagnated live-QI to relieve the stagnation of QI, the Chinese medicine preparation of relieving dysmenorrhea, in Chinese medicine preparation described in it, the parts by weight of various raw material can also be preferably: Herba Leonuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Caulis Perillae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Bupleuri 10 ~ 15 parts, Semen Platycladi 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Foeniculi 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Poria cum Radix Pini 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Rhizoma Zingiberis 10 ~ 15 parts, Cortex Albiziae 10 ~ 15 parts.
Described dispersing the stagnated live-QI to relieve the stagnation of QI, the Chinese medicine preparation of relieving dysmenorrhea, Chinese medicine preparation dosage form described in it can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine preparation, and when described preparation formulation is oral solutions, preparation method comprises:
A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.
In described step a, crude drug can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.
In described step b, the medicinal residues that ethanol extraction is crossed can be put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
In described step c, above-mentioned two kinds of component pastes can be condensed into pasty state, concentrated solution CO60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method preparation method of Chinese medicine preparation, and described preparation formulation is that the preparation method of capsule comprises:
A. described raw material is put into pulverizer grinding and sieving;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
In described step a, described raw material can be put into after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; In described step b, the particulate matter be left after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added 10 times of water gaging heating 1 ~ 2 hours reflux and extract 1 time; Above-mentioned 3 extracting solution are merged and leaves standstill; In described steps d, said extracted liquid can be merged, when concentrating under reduced pressure relative density is 80 DEG C 1.08 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m2, hothouse hot stream temperature is 80 DEG C, obtains raw material medicated powder; The raw material fine powder obtained after sieving and ethanol are refined medicated powder to mix and incapsulate.
Invention formulation is dispersing the stagnated live-QI to relieve the stagnation of QI, the dysmenorrhea that reply women causes because of endometriosis, have liver and kidney tonifying, nourishing YIN for decreasing fever, relieving restlessness is calmed the nerves the effect of merit, thus elimination dysmenorrhea, the easy dry irritability of disposition, spontaneous sweating occurs frequently, insomnia and dreamful sleep, vertigo and tinnitus, dysphoria unstable blood pressure etc. is levied, successful.Select drug matching again, regulating plant function of nervous system, reduce incretion balance obstacle, improve psychataxia symptom, maintain homergy, all medicine compatibilities play the kidney warming tonifying YIN altogether, the merit of adjusting and runing yang.In conjunction with clinical practice, endometriosis dysmenorrhea and Liver Channel functional disorder in close relations, treat time adopt treat from liver, based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, add soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. respectively at application drug for invigorating blood circulation and eliminating stasis simultaneously and adjust liver medicine, clinically obtain good curative effect.
Detailed description of the invention
There is no endometriosis name of disease in Chinese medicine ancient books to record, according to endometriosis clinical manifestation, dysmenorrhea, mass in the abdomen, menoxenia, the category such as infertile can be belonged to.Numerous discussion is had, the main and heart, liver, the dirty close relation of kidney three to the pathogeny of dysmenorrhea, wherein especially close with liver.Modern medicine observes endometriosis can cause various variety classes, pain in various degree, comprise dysmenorrhea, sexual anhedonia, defecation pain, chronic pelvic pain, low-back pain and be radiated to the pain etc. of part internal organs and limbs, widely distributedly distribute perfectly in harmony with Liver Channel." Medical Treasures of the Golden Chamber abdominal distention colic of cold type dyspepsia abnormal pulse card is controlled " cloud: " pulse at CUN KOU being stringy person, then contraction and pain in the hypochondrium." the many strings of pain arteries and veins, stringy pulse belongs to liver, liver governing tendons, and it is also relevant with liver that uterus is spasm shape contraction person.Illustrate dysmenorrhea and liver in close relations.Woman is congenital with liver, conditioning liver, and make its catharsis function normal, then store blood is devoted to one's duty, abundant CHONG meridian with unobstructed REN meridian, and QI and blood is in harmonious proportion, from the reason of painless warp.We think that treat from liver endometriosis dysmenorrhea is as the main rule for the treatment of at research, are significant to raising curative effect.
What dream precious jade " doctor's rock " of the Qing Dynasty carries: " all kinds of diseases and ailments are born in strongly fragrant, strongly fragrant and do not dredge, then the disease of all edema with the liver involved." woman's physiological cycle QI and blood easily fluctuates, feelings will is easy to melancholy, the pent-up of feelings will, depression of liver-QI, and the liver failing to maintain the normal flow of QI, causes depression and stagnation of QI, and QI and blood is tied mutually, and blood fortune is smooth, and a vessels of the uterus stasis blocking generation dysmenorrhea is appointed in punching.The essence of endometriosis dysmenorrhea is blood stasis, and key is then gas." qi being the governor of blood, blood being the material foundation of QI ", the interdependent and mutually promoting on physiology of gas and blood, interactional relation on pathology, finally determines in the treatment of dispersing the stagnated live-QI to relieve the stagnation of QI method in uterus endometriosis dysmenorrhea and has irreplaceable effect.Control when soothing the liver promoting QI circulation for relieving depression, liver controlling conveyance and dispersion function is normal, then QI and blood is in harmonious proportion, and smooth through working, general rule is not bitterly.Control suitable dispersing the stagnated live-QI to relieve the stagnation of QI, be equipped with activating QI to eliminate phlegm if desired, the methods such as movable blood soft hard.Before and after disconnected, Radix Semiaquilegiae gradually exhausts, kidney water dries up, edema with the liver involved is lost and is supported, the hepatic and renal YIN deficiency causes pre-postmenstrual syndromes, accordingly the pathogenesis side of sending, with the merit of its nourishing blood for regulating menstruation of the Radix Paeoniae Alba, suppressing the hyperactive liver pain relieving, astringing YIN to stop sweating in side, to separate blood deficiency, the deficiency of YIN has thermic menoxenia, and deficiecny of liver-YIN causes that headache is dizzy, card such as the rib side of body pain and night sweat due to yin deficiency etc.; Fructus Ligustri Lucidi has the effect of tonifying liver kidney yin, clearing away heat to improve acuity of vision, except soreness of waist and knee joint, and yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, the numbness of to have a dizzy spell etc.; Radix Salviae Miltiorrhizae heat clearing and damp drying, eliminating fire and detoxication, brings down a fever except steaming, and the solution deficiency of YIN causes warms sweating, the cards such as dysphoria with feverish sensation in the chest palms and soles.Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, Semen Cuscutae, Radix Polygoni Multiflori Preparata liver and kidney tonifying, nourishing YIN for decreasing fever, Semen Platycladi, Radix Polygalae, Fructus Foeniculi puies forward the effect that positive relieving restlessness is calmed the nerves, and all medicine compatibilities have clearing heat and relieving fidgetness, the kidney invigorating and essence nourishing, benefiting QI for activating blood circulation, bone strengthening mends marrow, eliminates forgetful insomnia, soreness of waist and knee joint, dizziness and tinnitus, xerostomia just difficult; Effect of menoxenia.
Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.
Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person, says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, then body is from light, sends out in vain also.Respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have son.Large bright main settling five organs, beneficial color, supports vital essence, long hair, Qiang Zhi.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food have son.Main impotence."
The flat sweet in the mouth of Semen Platycladi, the heart, kidney, large intestine channel.Effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, energy tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes the secret disease that Dengs." medicineization justice ": Semen Platycladi, the saturating heart of fragrance, body profit grows blood.Same Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis, be product clear in turbid, cure mainly mind void timid, palpitation with fear severe palpitation, color is wan and sallow, skin pruritus due to dryness, and the merit of the blood that all nourishes heart also.Get again abnormal smells from the patient all dense, return kidney in turbid, same to Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis, Fructus Lycii, Radix Achyranthis Bidentatae, be packing bone marrow, cure mainly damage of kidney-YIN, back severe disease, sufficient knee joint is weak, and night sweat due to yin deficiency, the power that all nourishing kidney is dry also.Sweet in the mouth also can delay liver, the deficiency of tonifying liver gallbladder, extremely reliable, but the flat power of property delay, should be multiplex be wonderful.
Radix Polygalae is bitter, pungent, tepor.GUIXIN, kidney, lung meridian.Function cures mainly Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Be applied to insomnia and dreamful sleep, severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off sensible, can happily gas and mind tranquilizing and the heart calming, kidney qi can be led to and strong will is not forgotten, be restoring normal coordination between the heart and kidney, stabilize mind, good merchantable brand that Fructus Alpiniae Oxyphyllae is known by force.Cure mainly the diseases such as the malaise of disarmony between the heart and kidney, insomnia, palpitation with fear, normal with Poria cum Radix Pini, Dens Draconis, Cinnabaris etc. the same use of medicinal for tranquilizing mind, as Radix Polygalae ball (" Zhang Shi doctor is led to "); Control forgetful card, normal and Radix Ginseng, Poria, the same use of Rhizoma Acori Graminei, as Kaixin San (" prescriptions worth thousand gold "), if Fang Zhongzai adds Poria cum Radix Pini, namely do not forget fall apart (" Standards of Diagnosis and Treatment ")." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, therefore can relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, thus same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, pole can lift fall into consolidating semen, handing-over extreme misery.
Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treatment scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.
Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation.
The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, QI invigorating, the capable hot disease in sky, pestilence miasma, mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.
Fructus Corni, cure mainly pathogen cold and heat under the heart, warming middle-JIAO, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., for China commonly uses rare Chinese medicine, applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " JINGUI SHENQI WAN " with Fructus Corni.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast." detailed outline " carries it: loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.
Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Caulis Perillae Caulis Perillae is a kind of Chinese medicine title.This product is the dry stem of labiate Folium Perillae Perillafrutescens (L.) Britt..Autumn taps after fruit maturation, and removing impurity, dries, or take advantage of fresh slices, dry.Meridian distribution of property and flavor: pungent, temperature.Return lung, spleen channel.Function cures mainly: regulating the flow of QI to ease the stomach, and pain relieving is antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement." book on Chinese herbal medicine is high former ": " main alleviating distention in middle-JIAO circulation of qi promoting, disappear diet, and reduce phlegm saliva.Control dysphagia and regurgitation, only cardiac and abdominal pain."
Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Dandelion Compositae belongs to herbaceos perennial.It is the plant of dietotherapeutic.Record according to Compendium of Material Medica, the flat sweet and slightly bitter taste of its property, has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and galgctogogue action, very effective to treatment mastitis.No matter decoct juice oral, or smash to mud external application, all there is effect.In addition, Herba Taraxaci also has the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, is widely used in clinical.Compendium of Material Medica has a cloud: " the tender Seedling of Herba Taraxaci is edible, eats that to control infectious disease especially good raw." Shennong's Herbal, Tang Materia Medica, the successive dynasties Medical monographs such as " Chinese medicine voluminous dictionary " all give high evaluation.
Radix Bupleuri clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia.Radix Bupleuri begins to be loaded in Shennong's Herbal, is classified as top grade.The phytomorph of history tree to Radix Bupleuri has description more." book on Chinese herbal medicine is just ": " Radix Bupleuri, cool loose with it with this person, the heat of suppressing the hyperactive liver.It is cool in nature, therefore separates alternate attack of chill and fever, flesh table hectic fever, and liver and gall fire is scorching, and chest and hypochondrium is tied, and doublely controls skin infection, and blood room is heated; Its property is fallen apart, therefore main typhoid fever pathogenic heat are not separated, epidemic febrile disease intenseness of heat, SHAO YANG headache, Liver Channel melancholia.
Oletum Trogopterori is the dry feces of trogopterus xanthipes Milne-Edwards, can be used for blood-stasis internal-depression, escape of blood from meridian hemorrhage, if woman uterine bleeding is through many, the purple polylith of color, stabbing pain of the lower abdomen.Both can single fry ground into powder, heat wine takes, again can with other drug with the use of.Promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.It is logical that Oletum Trogopterori hardship lets out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly." therefore " Bencao Jingshu " calls it, and " stasis passages through which vital energy circulates, gas must not be gone, and attacks the cards such as sharp pain, must use.”
Main component contained by Fructus Foeniculi is all Oleum Anisi Stellati, energy stimulating gastrointestinal neural blood vessel, and facilitating digestion liquid is secreted, and increases gastrointestinal peristalsis, gets rid of the gas accumulated, so there is effect of stomach invigorating, circulation of qi promoting; Sometimes gastrointestinal peristalsis can reduce again after excitement, thus contributes to alleviating spasm, easing the pain.Chinese medicine is used as medicine, and warm in nature, acrid in the mouth, returns liver,kidney,spleen, stomach warp.Function warming the liver kidney, warming the stomach gas, loose plug knot, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.For colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhes, few abdomen cold type of pain, abdominal distention, the diseases such as lack of appetite and vomiting.
Poria cum Radix Pini to crouch the sclerotium of hole platymiscium Poria [(Poria cocos Schw.) Wolf] for Polyporaceae, and original kind is rudimentary plant, is the fungus colonized on pinaster.Medicinal effects is dry sclerotia body.Nature and flavor are sweet, light flat.There are the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.For phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.Cortex Sclerotii Poriae, inducing diuresis to remove edema, the diseases such as the edema that wets for water." property of medicine opinion ": main infantile convulsion, tranquilizing the mind, mends tired; Main acute pain in the epigastrium heavily fortified point is full, and small intestinal is unfavorable.Poria cum Radix Pini is the Chinese medicine product of plant Poria, and former plant multiparasitization is on Pinus massoniana Lamb or Duan Mu, and its growth promoter can be divided into two stages: i.e. mycelia (white filament) stage and the sclerotium stage.Vegetative stage, mainly mycelia absorbs moisture and nutrition from wood surface, and secretase decomposes and transforms the organic matter (cellulose) in timber simultaneously, makes mycelia spread vigorous growth in wood.Second stage is that mycelia is coalescent agglomerating to middle and late stage, forms sclerotium (also known as knot etc.) gradually.Tie the quality of Siberian cocklebur size and strain, nutritional condition and the envirment factor such as temperature, humidity and have substantial connection.The strain of different cultivars, the time length of knot Siberian cocklebur is also different, and some kinds start to tie Siberian cocklebur after planting for 3 ~ 4 months, and some is then comparatively slow, needs 6 ~ 7 months.Early seasonal strain can be gathered in the crops after planting for 9 ~ 10 months, and late-maturing kind then needs 12 ~ 14 months.The common person of Poria cum Radix Pini is its sclerote.Mostly be irregular bulk, spherical, flat, Long Circle or oblong etc., not of uniform size, little person is as fist, and large person's diameter reaches 20 ~ 30 centimetres, or larger.The light taupe brown of epidermis or pitchy, in warty shrinkage, inner white is slightly with pink, is made up of countless mycelia.Sporophore umbrella shape, diameter 0.5 ~ 2 millimeter, peristoma is tooth slightly; Sexual generation is not easily seen, cellular, the crust of usual attached sclerotium and giving birth to, just white, after change light brown gradually into, polygon is made in hole, and load is bar-shaped, and basidiospore is oval to cylindrical, slightly flexing, one end point, smoothly, colourless, has special foul smell.
Rhizoma Zingiberis acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.Coldness and pain in the epigastrium; Vomiting; Have loose bowels, YANG-depletion is fainted inverse; Cold fluid-retention is breathed with cough; Arthralgia due to cold-dampnes." not Lu ": " control abdominal pain due to cold, attacked by pestiferous factors, cholera, distension, all poison of ailment said due to cold or exposure, stagnation of QI between skin, only hemoptysis.”
Rhizoma Chuanxiong is pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, is gynecological's common drug, has the effect of activating blood cirulation to regulate QI flow.
Cortex Albiziae: nature and flavor are sweet, flat.There is the merit of resolving depression and blood, mind calming, subduing inflammation.There is the effect controlling irritability, melancholy, insomnia, lung abscess, carbuncle, scrofula, injured bone.Antifertility action Cortex Albiziae cold water extract has significant antifertility action, and amniotic membrane intracavitary administration can make the young atrophy of middle pregnant rat tire, the pale and interruption of pregnancy of color and luster.People's gravid uterus bar is under the effect of Cortex Albiziae extracting solution, and shrink tension and amplitude all significantly increase, and contraction frequency then obviously reduces, and the effect of Cortex Albiziae is similar to oxytocin, but onset time is comparatively slow, and the persistent period is long.Cortex Albiziae antifertility effective ingredient is Saponin, and Cortex Albiziae Total saponin 1.78mg/kg subcutaneous injection has remarkable Antiimplantation Action, can reduce Rat Pregnancy number of animals and fetal tissues number, and termination of pregnancy rate is 86%.Also have remarkable interceptive effect in gestation administration on the 4th ~ 6th, termination of pregnancy rate is 40%.The injection of Cortex Albiziae general glycoside official jargon can make gestation rat afterbirth atrophy on the 6th ~ 7 dead, and mortality rate is 88%.70 μ g/kg lumbar injections (l/50 of mice LD50), every day 1 time, totally 3 days, can not make female Mus uterus weight childhood, show that its no estrogen sample is active.The bark of the multiple congener of Herba Albiziae all has significant excited uterus and causes Induction of abortion, and triterpenoid saponin as contained in principal columns of a hall tree (A, chinensis) all can cause animal to miscarry in each period administration of gestation, has significant excitation to the uterus of arteries and veins Mus or people.Contained by Alibizia Kalkora (Roxb.) Prain (A, kalkora) bark, Saponin also has the effects such as anti-implantation and antiearly fertility to rat.
The manufacturing process of the present invention's honey refining pill is: get Herba Leonuri 1000, Radix Paeoniae Alba 1000g, Fructus Rubi 1000g, Caulis Perillae 1000g, Radix Angelicae Sinensis 1000g, Fructus Corni 1000g, Herba Ecliptae 1000g, Radix Polygalae 1000g, Herba Taraxaci 1000g, Placenta Hominis 1000g, Fructus Ligustri Lucidi 1000g, Radix Polygoni Multiflori Preparata 1000g, Semen Cuscutae 1000g, Radix Bupleuri 1000g, Semen Platycladi 1000g, Rhizoma Chuanxiong 1000g, Oletum Trogopterori 1000g, vinegar Pericarpium Citri Reticulatae 1000g, Radix Salviae Miltiorrhizae 1000g, Fructus Foeniculi 1000g, Rhizoma Cyperi 1000g, Poria cum Radix Pini 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Zingiberis 1000g, Cortex Albiziae 1000g, getting described crude drug is soaked in 70%-80% ethanol, heating and refluxing extraction three times, 1.5 hours time, 1 hour, 1 hour, merge extractive liquid, filter, filtrate recycling ethanol, be concentrated into dry, vacuum drying at 60 DEG C, take out, pulverize, cross 100 mesh sieves, fine powder is for subsequent use, add Mel and make honey refining pill.
The manufacturing process of capsule of the present invention is: get Herba Leonuri 1100, Radix Paeoniae Alba 1200g, Fructus Rubi 1300g, Caulis Perillae 1200g, Radix Angelicae Sinensis 1300g, Fructus Corni 1200g, Radix Polygalae 1300g, Herba Taraxaci 1400g, Fructus Ligustri Lucidi 1100g, Radix Polygoni Multiflori Preparata 1300g, Radix Bupleuri 1400g, Semen Platycladi 1200g, Rhizoma Chuanxiong 1100g, Oletum Trogopterori 1300g, Radix Salviae Miltiorrhizae 1300g, Fructus Foeniculi 1300g, Rhizoma Cyperi 1100g, Poria cum Radix Pini 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Rhizoma Zingiberis 1200g, Cortex Albiziae 1200g, to add in 10 times amount ethanol heating extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill.Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, puts into oven drying and obtain component medicated powder, incapsulate and be made as capsule.Every capsules dress 0.3g.Can every 12 be one edition.
The manufacturing process of oral solutions of the present invention is: get Herba Leonuri 1300, Radix Paeoniae Alba 1100g, Fructus Rubi 1400g, Caulis Perillae 1200g, Radix Angelicae Sinensis 1300g, Fructus Corni 1400g, Radix Polygalae 1300g, Herba Taraxaci 1400g, Fructus Ligustri Lucidi 1100g, Radix Polygoni Multiflori Preparata 1300g, Radix Bupleuri 1400g, Semen Platycladi 1400g, Rhizoma Chuanxiong 1200g, Oletum Trogopterori 1400g, Radix Salviae Miltiorrhizae 1100g, Fructus Foeniculi 1300g, Rhizoma Cyperi 1200g, Poria cum Radix Pini 1200g, Rhizoma Atractylodis Macrocephalae 1300g, Rhizoma Zingiberis 1400g, Cortex Albiziae 1300g, get the soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, concentrated 30 minutes ~ 45 minutes of heating, be concentrated into extractum shape, stand for standby use, become component 1, 10 times of water gagings put into by the medicinal residues crossed by water extraction, heating and refluxing extraction 1 time, extraction time is 1 ~ 2 hour, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.38 extractum, concentrated 30 minutes ~ 45 minutes of heating, be concentrated into extractum shape, stand for standby use, become component 2.Above-mentioned two kinds of extractum are condensed into pasty state, concentrated solution CO 60 sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product.
Powder preparation process of the present invention is: get Herba Leonuri 1200g, Radix Paeoniae Alba 1500g, Fructus Rubi 1200g, Caulis Perillae 1200g, Radix Angelicae Sinensis 1400g, Fructus Corni 1400g, Radix Polygalae 1300g, Herba Taraxaci 1400g, Fructus Ligustri Lucidi 1100g, Radix Polygoni Multiflori Preparata 1500g, Radix Bupleuri 1400g, Semen Platycladi 1400g, Rhizoma Chuanxiong 1200g, Oletum Trogopterori 1400g Radix Salviae Miltiorrhizae 1100g, Fructus Foeniculi 1300g, Rhizoma Cyperi 1400g, Poria cum Radix Pini 1400g, Rhizoma Atractylodis Macrocephalae 1300g, Rhizoma Zingiberis 1400g, Cortex Albiziae 1300g, medical material soaks 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; The second time that adds water filtering residue heats, and boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state medicinal liquid, puts into 80 degree, baking oven and dries to Powdered.
Pharmacological toxicity is tested
1, acute toxicity test
Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage preparation capsule of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
2, long term toxicity test
Select SD rat, give the Chinese medicine preparation granule of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Pharmacological experiment illustrates:
1 data and method
1.1 physical data: choose my institute's department of Chinese medicine and outpatients of gynecology 96 example.With consultation time successively by patient according to A/B circular order random packet, A group includes treatment group in, and B group includes matched group in.Treatment group 48 example, 15 ~ 30 years old age, average 20.3 years old; The course of disease 3 months ~ 7 years, average 3.03.Pain degree classification: light, in, severe person is respectively 6 examples, 28 examples, 14 examples.Matched group 48 example, 16 ~ 29 years old age, average 19.8 years old; The course of disease 5 months ~ 7 years, average 3.04.Pain degree classification: light, in, severe person is respectively 7 examples, 26 examples, 15 examples.The detailed gynecological clinic inspection of equal warp, result is endometriosis, and other show no obvious abnormalities.The factor no significant difference (P > 0.05) such as two groups of patient ages, the course of disease, state of an illness, have comparability.
1.2 diagnostic criterias: it is as follows that " Chinese medical disease Standardization of diagnosis and curative effect " with reference to State Administration of Traditional Chinese Medicine's issue drafts diagnostic criteria: menstrual period or lower abdomen pain before and after row, pain and waist sacrum, very then faint; In periodical attack; And the stomachache caused by eliminating organic disease.
1.3 inclusive criterias: meet diagnostic criteria, at 15 ~ 30 years old age, are ready accept inactive other treatment this therapy and complete 3 menstrual cycle therapists.
1.4 exclusion standards: the gynaecopathia caused by genitals's organic disease is as pelvic inflammatory disease, adenomyosis, hysteromyoma etc.; Intrauterine places birth control apparatus (being commonly called as intrauterine device); Be associated with the serious life-threatening primary disease patient such as cardiovascular and cerebrovascular vessel and disease of hematopoietic system; The organ function injury persons such as Liver and kidney; Mental sickness, acute infectious disease, tumor patient; Get rid of and accepted other associated therapy, this research effect index observer can be affected.
1.5 Therapeutic Method: matched group is with ibuprofen modified release capsule oral medication, and treatment group Chinese medicine preparation of the present invention is treated.Matched group is oral with ibuprofen modified release capsule (ibuprofen, Sino-America Tianjin Shike Pharmaceutical Co., Ltd. produces) 0.3g, and 1 time/d, severe pain person can 2 times/d.Start to take medicine when dysmenorrhea, pain disappears then drug withdrawal.Take 3 menstrual cycle continuously;
Invention formulation raw material is: Herba Leonuri 10g, Radix Paeoniae Alba 12g, Fructus Rubi 13g, Caulis Perillae 12g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 11g, Oletum Trogopterori 13g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 13g, Rhizoma Cyperi 11g, Poria cum Radix Pini 12g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Zingiberis 12g, Cortex Albiziae 12g, makes oral solutions, 1 dose/d, divide 3 decoction being taken warmly after meal, serve on 7 doses, continuous 3 menstrual cycle.
1.6 efficacy assessment standards: formulate with reference to " new Chinese medicine guideline of clinical investigations " and " Chinese medical disease Standardization of diagnosis and curative effect ".Cure: pain disappears, and recurrence is seen at continuous 3 menstrual cycle ends; Take a turn for the better: pain relief or pain disappear, but can not maintain more than 3 months; Do not heal: pain has no improvement.
2 results
Two groups of comparitive study: in table 1.
Table 1 liang group comparitive study (example)
Note: compare with matched group, 1. P < 0.01 clinical data
Detailed description of the invention:
Embodiment 1: example 1: Hu, female, 28 years old.Abdominal pain during menstruation increases the weight of more than 3 years.Patient moves ahead peritoneoscope right ovary chocolate cyst Excision for 4 years, within nearly 2 years, occurs that menstrual period, lower abdominal distention pain gradually increased the weight of, and drink cold drink then pain is acute, hot compress alleviation of pain, medium through measuring, color is dark red block, companion's vomiting during dysmenorrhea, coolness of extremities, be in a cold sweat, very then faint, purplish tongue is dark, white and thin fur, stringy and hesitant pulse.Ultrasound diagnosis: uterus, adnexa show no obvious abnormalities.Tcm diagnosis is dysmenorrhea, and card belongs to liver-cold blood stasis.Control with dispelling cold by warming the meridian, promoting blood circulation, removing blood stasis and relieving pain, side with SHAOFU ZHUYN DECOCTION plus-minus, but do not get better always turn.Use invention formulation, Fang Yong: Herba Leonuri 12g, Radix Paeoniae Alba 14g, Fructus Rubi 14g, Caulis Perillae 12g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 11g, Oletum Trogopterori 15g, vinegar Pericarpium Citri Reticulatae 11g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 13g, Rhizoma Cyperi 11g, Poria cum Radix Pini 12g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Zingiberis 13g, Cortex Albiziae 14g, makes oral liquid, every day 1 dose 3, and patient takes medicine to suffer from abdominal pain after 7 doses menstrual period and obviously alleviates.Starting to take oral liquid with premenstrual 1 week was again 1 course for the treatment of, basic alleviation of suffering from abdominal pain after treating for 3 courses for the treatment of continuously, successful pregnancies in 2012.
Embodiment 2: example 2: pay certain, female, 32 years old.Abdominal pain during menstruation companion does not practise contraception unpregnancy more than 6 years.Dysmenorrhea generally at premenstrual 1 ~ 2 day to menstruation the 2nd day obviously, treats that menstrual blood volume is gradually many, pain relief after having large clot to discharge.Menstruation 30 days one tide, measure medium, color is purple, have clot, with distention and pain of breast before menstruation, there is purple gas on red tongue limit, wiry and frequent pulse.Tcm diagnosis is dysmenorrhea, and card belongs to stagnation of liver-QI blood stasis.Control with dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, side's Gexia Zhuyu Tang plus-minus, but always intermittent, DeGrain.Use invention formulation instead, Fang Yong: Herba Leonuri 13g, Radix Paeoniae Alba 14g, Fructus Rubi 14g, Caulis Perillae 12g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 11g, Oletum Trogopterori 15g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 12g, Rhizoma Cyperi 13g, Poria cum Radix Pini 14g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Zingiberis 13g, Cortex Albiziae 14g, makes granule, and every day, three guarantees were taken after mixing it with water.Advise premenstrual 1 week clothes, serve on 7 days.Patient took medicine in premenstrual 1 week of continuous 3 cycles, and symptom is obviously alleviated, and successful pregnancies.
Embodiment 3: poplar, female is 32 years old, married.First visit on May 2 in 2011.To be admitted to hospital through going and feel the lower abdomen pain main suit of 2 years after clean, once from taking YUANHU ZHITONG PIAN and FUKE QIANJIN PIAN etc., heavy time light during stomachache.Previously menstruation rule, amount can, occurred before 2 years feeling lower abdomen pain through row and after clean, few through row amount, color be light red, accompany that waist hip is aching and tired, both legs are unable, dizzy, tinnitus.Pregnant 1 produces 1, last menstrual period: on July 21st, 2011.Gynecologial examination: pudendum: product type; Vagina: smooth, a small amount of secretions; Cervix uteri: loose, eck is shown in several adenocele; Gong Ti: bend position afterwards, Chang great, in matter, touches a tender spot (+); Double accessory: all slightly thicken.Look into anti-endometrial antibodies IgG, IgM all (-), CA125 is negative, ultrasound diagnosis: uterus adnexa no abnormality seen.Body of the tongue is light red, white and thin fur, thready pulse without strength.Tcm diagnosis: married woman suffers from abdominal pain; Western medicine diagnose: endometriosis.Control suitable the kidney invigorating temperature palace, blood-activating analgetic.Oral liquid is made with invention formulation.Fang Yong: Herba Leonuri 12g, Radix Paeoniae Alba 13g, Fructus Rubi 13g, Caulis Perillae 14g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 14g, Oletum Trogopterori 12g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 12g, Rhizoma Cyperi 13g, Poria cum Radix Pini 13g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 13g, Cortex Albiziae 14g, further consultation after serveing on March, private prosecution disappears through row or postmenstrual abdominal pain, and follow-up study 3 months, has no recurrence.Now success is conceived.

Claims (10)

1. treat the Chinese medicine preparation that endometriosis causes dysmenorrhea for one kind, it is characterized in that, the raw material of Chinese medicine composition of described Chinese medicine preparation is made up of the various medical materials of following parts by weight: Herba Leonuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Caulis Perillae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Poria cum Radix Pini 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts.
2. treat the Chinese medicine preparation that endometriosis causes dysmenorrhea according to claim 1, it is characterized in that, the raw material of Chinese medicine composition of described Chinese medicine preparation is made up of the various medical materials of following parts by weight: Herba Leonuri 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Caulis Perillae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Radix Polygalae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Radix Bupleuri 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Oletum Trogopterori 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Fructus Foeniculi 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Poria cum Radix Pini 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Rhizoma Zingiberis 10 ~ 20 parts, Cortex Albiziae 10 ~ 20 parts.
3. treat the Chinese medicine preparation that endometriosis causes dysmenorrhea according to claim 1, it is characterized in that, the raw material of Chinese medicine composition of described Chinese medicine preparation is made up of the various medical materials of following parts by weight: Herba Leonuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Caulis Perillae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Polygalae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Radix Bupleuri 10 ~ 15 parts, Semen Platycladi 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Oletum Trogopterori 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Fructus Foeniculi 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Poria cum Radix Pini 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Rhizoma Zingiberis 10 ~ 15 parts, Cortex Albiziae 10 ~ 15 parts.
4. according to any one of claims 1 to 3, treat the Chinese medicine preparation that endometriosis causes dysmenorrhea, it is characterized in that, the dosage form of described Chinese medicine preparation is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup.
5. according to any one of claims 1 to 3, treat the preparation method that endometriosis causes the Chinese medicine preparation of dysmenorrhea, it is characterized in that, described preparation formulation is oral solutions, and its preparation method comprises:
A, get raw material and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, medicinal residues water extraction 2 times, thickening filtration is paste, is component 2;
C, above-mentioned two kinds of pastes are condensed into pasty state, sterilizing, add dextrin, then vacuum freezing sealing.
6. preparation method according to claim 5, is characterized in that, in described step a, get raw material to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.
7. preparation method according to claim 6, it is characterized in that, in described step b, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
8. preparation method according to claim 6, is characterized in that, in described step c, above-mentioned two kinds of component pastes are condensed into pasty state, concentrated solution Co 60sterilizing, irradiation dose 8k, adds dextrin, then vacuum canning sealing and get final product, and directly drinks during use.
9. according to any one of claims 1 to 3, treat the preparation method that endometriosis causes the Chinese medicine preparation of dysmenorrhea, it is characterized in that, described preparation formulation is capsule, and its preparation method comprises:
A. described raw material is put into pulverizer grinding and sieving;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 1 time;
D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
10. the preparation method of capsule according to claim 9, it is characterized in that, in described step a, described raw material is put into after pulverizer is pulverized and cross 120 order dusting covers, the enable fine powder amount by 120 mesh sieves reaches 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; In described step b, the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating 1 ~ 2 hours reflux and extract 1 time; Above-mentioned 3 extracting solution are merged and leaves standstill; In described steps d, by said extracted liquid merge, when concentrating under reduced pressure relative density is 80 DEG C 1.08 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m 2, hothouse hot stream temperature is 80 DEG C, obtains raw material medicated powder; The raw material fine powder obtained after sieving and ethanol are refined medicated powder to mix and incapsulate.
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WO2019092579A1 (en) * 2017-11-09 2019-05-16 Sistemi Salute S.R.L. Substances and compositions for the use in the treatment of endometriosis and endometriosis associated symptoms

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559204A (en) * 2009-05-22 2009-10-21 邓丽菊 Traditional Chinese medicine compound treating irregular menstruation and dysmenorrheal and application thereof in preparing hygienic products of women

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559204A (en) * 2009-05-22 2009-10-21 邓丽菊 Traditional Chinese medicine compound treating irregular menstruation and dysmenorrheal and application thereof in preparing hygienic products of women

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
南京中医药大学.五灵脂等.《中药大辞典》.上海科学技术出版社,2006, *

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