CN105148192A - Medicine for treating chronic cholecystitis and preparation method thereof - Google Patents
Medicine for treating chronic cholecystitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides medicine for treating chronic cholecystitis. The medicine is prepared from oriental wormwood, rhubarb, poria cocos, fructus aurantii immaturus, gentian, myrrh, liriope spicata, eclipta, polygonatum kingianum, radix pseudostellariae, saururus chinensis, saururus chinensis, merremia hungaiensis, corydalis cheilanthifolia, cynanchum mooreanum, eurya chinensis, finger citron, solanum lyratum thumb, herba desmodii styracifolii, caulis bambusae in taeniis and curcuma. The medicine is exact in therapeutic effect and is obviously superior to western medicine, the advantages of traditional Chinese medicine are embodied, a patient can tolerate the medicine easily, no obvious untoward effect exists, and the medicine can become a preferred alternative for clinically treating chronic cholecystitis, and is worthy of popularization.
Description
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of medicine being used for the treatment of chronic cholecystitis.
Background technology
Chronic cholecystitis is the gallbladder chronic inflammatory disease because some factors such as calculus or proliferation of fibrous tissue cause, and is common clinical, frequently-occurring disease, and the course of disease is chronic persistent, and easy recurrent exerbation, have a strong impact on the quality of life of patient.
Chronic cholecystitis morbidity has substantial connection with human body disturbance of lipoid metabolism and gallbladder emptying function obstacle, also may be that acute cholecystitis treatment is not thoroughly left over the chronic bacterial infection, the inspissated bile that cause or backflows into the chemical stimulation result of the pancreatic juice of gallbladder.Its pathogeny is attributable to: surfeit delicious food, thick greasy and hungry full immoderate; Disorder of emotion; Bacteriological infection; Biliary tract parasitic infection.Eat unclean thing, some roundworm eggs, relic or Hua Zhicui trematodiasis ovum drive in the wrong direction and enter biliary tract, bring out gallbladder and cause inflammation.In factors, any one factor individualism, all can make body dysfunction, causes the dysfunction of the nerve of biliary system, blood vessel, muscle and body of gland, brings out infection, causes gallbladder inflammation.
This disease belongs to the traditional Chinese medical science " hypochondriac pain ", " gallbladder-distention " category.Diseased region is in liver and gall, how relevant with taste.The excretion of bile is logical falls function, need lean on irritability free flow of qi, if irritability catharsis is not normal, and depression of liver-QI, perverse and unreasonable manner violates spleen, and damage of the spleen is wet poly-wine warm then; Or damp and hot friendship is steamed, strongly fragrant resistance gallbladder internal organs, then bile is stopped up stagnant, again burnt spleen and stomach function in impact, with the passing of time changes source deficient, venation block, and produces chronic cholecystitis symptom.The traditional Chinese medical science is thought, the gallbladder being attached to the liver, and with liver phase the exterior and the interior, gallbladder is " fu-viscera with clear juice ", with logical reduce to suitable.The factors such as feelings will not smooth, cold temperature discord, eating and drinking without temperance all can affect the catharsis of liver and the logical function of falling of gallbladder internal organs, make bile excretion not smooth.Gallbladder is clean FU-organ, does not damp and hotly for a long time change, and stifling bile, is condensed into sandstone.Therefore depression of liver-QI, damp-heat accumulation is main pathogenesis, and with depressed liver-energy dispersing and QI regulating in treatment, clear sharp purging FU-organs, clearing heat and expelling damp, invigorating the spleen and replenishing QI is principle.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of chronic cholecystitis, it adopts tcm syndrome differentiation and treatment, determined curative effect, obviously be better than doctor trained in Western medicine, embody the advantage of the traditional Chinese medical science, and patient easily tolerates, without obvious untoward reaction, the preferred option of clinical treatment chronic cholecystitis can be become, be worthy to be popularized.
For solving the problems of the technologies described above, the invention provides a kind of medicine being used for the treatment of chronic cholecystitis, its crude drug comprises Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Poria, Fructus Aurantii Immaturus, Radix Gentianae, Myrrha, Radix Liriopes, Herba Ecliptae, Rhizoma Polygonati, Radix Pseudostellariae, Rhizoma Saururi (Herba Saururi), Ipomoea hungaiensis Lingelsh. Et Borza., rock spring grass, Radix Tylophorae arenicolae, Radix Euryae Chinensis, Fructus Citri Sarcodactylis, Herba Solani Lyrati, Herba Desmodii Styracifolii, Caulis Bambusae In Taenia and Radix Curcumae.
Wherein, in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 23 weight portion ~ 28 weight portion, Radix Et Rhizoma Rhei 17 weight portion ~ 22 weight portion, Poria 13 weight portion ~ 18 weight portion, Fructus Aurantii Immaturus 13 weight portion ~ 18 weight portion, Radix Gentianae 20 weight portion ~ 25 weight portion, Myrrha 13 weight portion ~ 18 weight portion, Radix Liriopes 21 weight portion ~ 26 weight portion, Herba Ecliptae 15 weight portion ~ 20 weight portion, Rhizoma Polygonati 23 weight portion ~ 28 weight portion, Radix Pseudostellariae 31 weight portion ~ 36 weight portion, Rhizoma Saururi (Herba Saururi) 15 weight portion ~ 20 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 18 weight portion ~ 23 weight portion, rock spring grass 21 weight portion ~ 26 weight portions, Radix Tylophorae arenicolae 23 weight portion ~ 28 weight portion, Radix Euryae Chinensis 17 weight portion ~ 22 weight portion, Fructus Citri Sarcodactylis 25 weight portion ~ 30 weight portion, Herba Solani Lyrati 23 weight portion ~ 28 weight portion, Herba Desmodii Styracifolii 25 weight portion ~ 30 weight portion, Caulis Bambusae In Taenia 23 weight portion ~ 28 weight portion and Radix Curcumae 26 weight portion ~ 31 weight portion.
Wherein, in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 24 weight portion ~ 27 weight portion, Radix Et Rhizoma Rhei 18 weight portion ~ 21 weight portion, Poria 14 weight portion ~ 17 weight portion, Fructus Aurantii Immaturus 14 weight portion ~ 17 weight portion, Radix Gentianae 21 weight portion ~ 24 weight portion, Myrrha 14 weight portion ~ 17 weight portion, Radix Liriopes 22 weight portion ~ 25 weight portion, Herba Ecliptae 16 weight portion ~ 19 weight portion, Rhizoma Polygonati 24 weight portion ~ 27 weight portion, Radix Pseudostellariae 32 weight portion ~ 35 weight portion, Rhizoma Saururi (Herba Saururi) 16 weight portion ~ 19 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 19 weight portion ~ 22 weight portion, rock spring grass 22 weight portion ~ 25 weight portions, Radix Tylophorae arenicolae 24 weight portion ~ 27 weight portion, Radix Euryae Chinensis 18 weight portion ~ 21 weight portion, Fructus Citri Sarcodactylis 26 weight portion ~ 29 weight portion, Herba Solani Lyrati 24 weight portion ~ 27 weight portion, Herba Desmodii Styracifolii 26 weight portion ~ 29 weight portion, Caulis Bambusae In Taenia 24 weight portion ~ 27 weight portion and Radix Curcumae 27 weight portion ~ 30 weight portion.
Wherein, in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 25 weight portion, Radix Et Rhizoma Rhei 19 weight portion, Poria 15 weight portion, Fructus Aurantii Immaturus 15 weight portion, Radix Gentianae 22 weight portion, Myrrha 15 weight portion, Radix Liriopes 23 weight portion, Herba Ecliptae 17 weight portion, Rhizoma Polygonati 25 weight portion, Radix Pseudostellariae 33 weight portion, Rhizoma Saururi (Herba Saururi) 17 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 20 weight portion, rock spring grass 23 weight portions, Radix Tylophorae arenicolae 25 weight portion, Radix Euryae Chinensis 19 weight portion, Fructus Citri Sarcodactylis 27 weight portion, Herba Solani Lyrati 25 weight portion, Herba Desmodii Styracifolii 27 weight portion, Caulis Bambusae In Taenia 25 weight portion and Radix Curcumae 28 weight portion.
Medicine provided by the invention is endo-medicine, can be prepared into pharmaceutically acceptable any dosage form as required, preferably be prepared into decoction liquor, powder, electuary, granule, tablet, capsule, be preferably prepared into capsule further.
The present invention also provides said medicine as the preparation method of capsule, specifically comprises:
The first step, puts into pulverizer grinding and sieving by described each crude drug;
Second step, puts into ethanol heating and refluxing extraction 2 times, merge extractive liquid, by the particulate matter be left after sieving;
3rd step, then get the medicinal residues after above-mentioned ethanol extraction, the heating and refluxing extraction that adds water 2 times, merge extractive liquid;
4th step, two kinds of extracting solution second step and the 3rd step obtained merge, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
The described first step is specially further, and put into by described raw material after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collects by the raw material fine powder of 100 mesh sieves for subsequent use;
In described second step, putting into relative to its volume 2 ~ 4 times of determining alcohols by the particulate matter be left after sieving is 70% ~ 80% ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by 2 extracting solution and leaves standstill, obtain the first extracting solution.
In described 3rd step, the medicinal residues crossed by ethanol extraction in second step add and extract 2 times relative to its volume 4 ~ 6 times of water gagings heating 1 ~ 2 hours reflux; Above-mentioned 2 extracting solution are merged and leaves standstill, obtain the second extracting solution.
In described 4th step, above-mentioned first extracting solution and the second extracting solution are merged, when concentrating under reduced pressure relative density is 50 DEG C 1.05 filtrate, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 80 DEG C, obtains raw material medicated powder, and the raw material medicated powder that the raw material fine powder obtained after the first step being sieved and the 4th step obtain mixes and incapsulates.
Beneficial effect of the present invention:
The medicine being used for the treatment of chronic cholecystitis provided by the invention, it adopts tcm syndrome differentiation and treatment, determined curative effect, obviously be better than doctor trained in Western medicine, embody the advantage of the traditional Chinese medical science, and patient easily tolerate, without obvious untoward reaction, the preferred option of clinical treatment chronic cholecystitis can be become, be worthy to be popularized.
Detailed description of the invention
The traditional Chinese medical science is thought, the gallbladder being attached to the liver, built-in refined juice, and it is through venation liver." this defeated section of Ling Shu Miraculous Pivot or Divine Axis " claims it to be " the fu-organ that contains refined juice ".Thousand Golden Prescriptions is referred to as " fu-viscera with clear juice "." Plain Questions the five internal organs another matter " is referred to as again " extraordinary Fu-organ " because of its " installing but not discharging ".Though gallbladder belongs to one of six internal organs, but has the feature being different from other five hollow organs, i.e. " installing but not discharging ".Mainly cloth is mutually fiery for the function of gallbladder, secretes bile, and does not pass digesting and absorbing the essence of foodstuff waste matter.Gallbladder internal organs should profit, should clearly, should dredge, should lead to.If courage depression, sick.As " Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles " section is said: " six internal organs gas, wins for anger, courage strongly fragrant and not Shu Ze be easy to angry "; " excessive anger impairing the liver ".The liver belonging to wood, inside posts few sun mutually fiery." a Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates section ": " liver has strongly fragrant, and its air-flow is in two axils." the fiery same gas of wood, anger actually, void is then feared, and illustrates that liver and gallbladder are often carried mutually and claim on pathogenesis.Liver is fluent with catharsis is normal, and to fall behavior suitable with logical for gallbladder, the catharsis function of liver and the secretion of bile, drain closely related.The Nervous and Mental Factors such as worried, angry, easily causes stagnation of QI impairing the liver, stagnation of QI due to depression of the liver then bile to check interior life damp and hot and fall ill.Weather is not normal, the heresy that the bath that is affected by the cold is wet, all can be strongly fragrant and heat-transformation is lit a fire, and wood fire is with sick, then suffocating of liver and gall is unfavorable and fall ill.Eating and drinking without temperance, eating and drinking too much at one meal, eats too much greasy or is addicted to drink, or the pungent thing decocting stir-fry of state food, impairing the spleen and stomach, and dysfunction of the spleen in transportation, water-damp not being transformed, holds back to accumulate turning to heat for a long time, hinder in liver and gall, the liver failing to maintain the normal flow of QI, then bile excretion is not freely fallen ill.Malnutrition due to parasitic infestation can encourage damp and hot, the damp and hot parasitism being conducive to polypide, and worm property happiness brill is altered, and scurry into biliary tract, courage is obstructed and pathogenic.Occupy ground moist, daily life is inappropriate then affects transformation and transportation of the spleen and stomach for a long time, causes damp and hot stagnation and does not change, pent up with the passing of time then suffocating of liver and gall unfavorable, stagnation of QI due to depression of the liver, Yu Ze heat-transformation fire-transformation of a specified duration and causing a disease.In a word, the obstructed system of bile due to QI stagnation of the liver and galibladder and the stagnant knot of damp-heat in middle-JIAO, and the stagnation of QI and damp and hot be encourage mutually, QI depression of the liver and gallbladder perverse and unreasonable manner and gram taste, spleen injury, damp and hot accumulate long-pending, edema with the liver involved restriction or checking relation in five elements, then damp and hot more vehement.Burnt in damp and hot pent-up, affect the logical of gallbladder and fall, force on bile general, the skin and turning to be yellow of contaminating.Damp and hot heavier, QI and blood hypochondriac lump gallbladder internal organs, poly-not the faling apart of knot forms pain, and the long-pending not dispersion of heat forms pus of carbuncle.
In a word, the cause of disease of primary disease can be summarized as: 1, endogenous cause of ill: feelings will is not smooth, and mainly because rage anger is vexed or be worried to excess so that stagnation of liver-QI damage of the spleen, gallbladder loses logical falling, and forms primary disease.2, exopathogenic factor: eating and drinking without temperance, surfeit delicious food are grown greasy, process rich thing, so that make humidogene heat or diseases caused by exogenous pathogenic factor Shi Re Bing Pian, evil strongly fragrantly not to understand or evil turbid being detained forms because of the ascariasis of biliary tract.
In sum, the generation of primary disease is how unsuccessful by feelings will, depression of liver-QI, and perverse and unreasonable manner violates spleen; Or damage temper of overworking; Addicted to food rich and fatty diet, stagnant middle Jiao of Kui: and sense is cold by evil, direct attack is lunar, and temper is cut down; Or the impairment of the spleen of being worried to excess, damage of the spleen is wet poly-wine warm then; Or damp and hot friendship is steamed, strongly fragrant resistance gallbladder internal organs; Or the ascariasis of biliary tract is violated inverse, evil to be turbidly detained, finally all can causing gallbladder internal organs, logical to fall row not normal, and cholestasis is smooth, again burnt spleen and stomach function in impact, and with the passing of time change source short, venation tinea hinders, and produces the series of clinical manifestations of chronic cholecystitis.
Based on above-mentioned theory of Chinese medical science, the present invention proposes with depressed liver-energy dispersing and QI regulating, clear sharp purging FU-organs, clearing heat and expelling damp, invigorating the spleen and replenishing QI is principle, there is provided a kind of medicine being used for the treatment of chronic cholecystitis, its crude drug comprises Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Poria, Fructus Aurantii Immaturus, Radix Gentianae, Myrrha, Radix Liriopes, Herba Ecliptae, Rhizoma Polygonati, Radix Pseudostellariae, Rhizoma Saururi (Herba Saururi), Ipomoea hungaiensis Lingelsh. Et Borza., rock spring grass, Radix Tylophorae arenicolae, Radix Euryae Chinensis, Fructus Citri Sarcodactylis, Herba Solani Lyrati, Herba Desmodii Styracifolii, Caulis Bambusae In Taenia and Radix Curcumae.
Further preferably, described medicine is only prepared from by above-mentioned raw materials medicine.
In described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 23 weight portion ~ 28 weight portion, Radix Et Rhizoma Rhei 17 weight portion ~ 22 weight portion, Poria 13 weight portion ~ 18 weight portion, Fructus Aurantii Immaturus 13 weight portion ~ 18 weight portion, Radix Gentianae 20 weight portion ~ 25 weight portion, Myrrha 13 weight portion ~ 18 weight portion, Radix Liriopes 21 weight portion ~ 26 weight portion, Herba Ecliptae 15 weight portion ~ 20 weight portion, Rhizoma Polygonati 23 weight portion ~ 28 weight portion, Radix Pseudostellariae 31 weight portion ~ 36 weight portion, Rhizoma Saururi (Herba Saururi) 15 weight portion ~ 20 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 18 weight portion ~ 23 weight portion, rock spring grass 21 weight portion ~ 26 weight portions, Radix Tylophorae arenicolae 23 weight portion ~ 28 weight portion, Radix Euryae Chinensis 17 weight portion ~ 22 weight portion, Fructus Citri Sarcodactylis 25 weight portion ~ 30 weight portion, Herba Solani Lyrati 23 weight portion ~ 28 weight portion, Herba Desmodii Styracifolii 25 weight portion ~ 30 weight portion, Caulis Bambusae In Taenia 23 weight portion ~ 28 weight portion and Radix Curcumae 26 weight portion ~ 31 weight portion.
Further preferably, in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 24 weight portion ~ 27 weight portion, Radix Et Rhizoma Rhei 18 weight portion ~ 21 weight portion, Poria 14 weight portion ~ 17 weight portion, Fructus Aurantii Immaturus 14 weight portion ~ 17 weight portion, Radix Gentianae 21 weight portion ~ 24 weight portion, Myrrha 14 weight portion ~ 17 weight portion, Radix Liriopes 22 weight portion ~ 25 weight portion, Herba Ecliptae 16 weight portion ~ 19 weight portion, Rhizoma Polygonati 24 weight portion ~ 27 weight portion, Radix Pseudostellariae 32 weight portion ~ 35 weight portion, Rhizoma Saururi (Herba Saururi) 16 weight portion ~ 19 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 19 weight portion ~ 22 weight portion, rock spring grass 22 weight portion ~ 25 weight portions, Radix Tylophorae arenicolae 24 weight portion ~ 27 weight portion, Radix Euryae Chinensis 18 weight portion ~ 21 weight portion, Fructus Citri Sarcodactylis 26 weight portion ~ 29 weight portion, Herba Solani Lyrati 24 weight portion ~ 27 weight portion, Herba Desmodii Styracifolii 26 weight portion ~ 29 weight portion, Caulis Bambusae In Taenia 24 weight portion ~ 27 weight portion and Radix Curcumae 27 weight portion ~ 30 weight portion.
Most preferably, in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 25 weight portion, Radix Et Rhizoma Rhei 19 weight portion, Poria 15 weight portion, Fructus Aurantii Immaturus 15 weight portion, Radix Gentianae 22 weight portion, Myrrha 15 weight portion, Radix Liriopes 23 weight portion, Herba Ecliptae 17 weight portion, Rhizoma Polygonati 25 weight portion, Radix Pseudostellariae 33 weight portion, Rhizoma Saururi (Herba Saururi) 17 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 20 weight portion, rock spring grass 23 weight portions, Radix Tylophorae arenicolae 25 weight portion, Radix Euryae Chinensis 19 weight portion, Fructus Citri Sarcodactylis 27 weight portion, Herba Solani Lyrati 25 weight portion, Herba Desmodii Styracifolii 27 weight portion, Caulis Bambusae In Taenia 25 weight portion and Radix Curcumae 28 weight portion.
Each crude drug pharmacology is as follows:
Herba Artemisiae Scopariae: acrid in the mouth, hardship, cold nature, returns spleen, stomach, liver, gallbladder meridian, cures mainly jaundice, dysuria, the cards such as eczema pruritus, the effects such as pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach, large intestine, liver, spleen channel, have attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald.
Poria: sweet in the mouth, light, property is put down, and enters spleen, lung, bladder, heart channel, has the effect of eliminating dampness and diuresis, spleen invigorating mind calming, be mainly used in the edema of retention of water-damp, dysuria; The pyretic stranguria of damp-heat accumulation, the card such as anorexia and loose stool, phlegm retention stagnation, epilepsy of stagnation of dampness due to deficiency of the spleen.
Fructus Aurantii Immaturus: bitter in the mouth, pungent, cold nature, enters spleen, stomach warp, has dispelling the stagnated QI removing food stagnancy, expectorant except the effect of painful abdominal mass, be mainly used in stagnant in stop, the YangmingFushi syndrome of distension and fullness in the abdomen, constipation.
Radix Gentianae: bitter in the mouth, cold in nature, enters liver, gallbladder meridian, has heat clearing and damp drying, falls the effect of letting out liver-fire and function of gallbladder promoting, and the breast side of body being mainly used in dampness-heat of the liver caused is had a pain, and bitter taste is deaf, conjunctival congestion and swelling pain; Jaundice due to damp-heat; The dizzy order of flaming up of liver-fire swells; The high heat of liver-fire wind-transformation is through taking out; The card such as leucorrhea, dysuria of damp invasion of lower energizer.
Myrrha: bitter in the mouth, pungent, property is put down, and enters liver, spleen, the heart, kidney channel, has loose blood blood stasis removing, effect of subduing swelling and relieving pain, for controlling the cards such as traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Radix Liriopes: latin name liriopesradix, sweet in the mouth, micro-hardship, cold nature, GUIXIN, lung, stomach warp, have YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire, and for dryness of the lung dry cough, cough due to consumptive disease, Tianjin wound is thirsty, vexed insomnia, the cards such as dryness of the intestine constipation.
Herba Ecliptae: have another name called Herba Ecliptae, ink grass, floods and droughts lotus, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play not liver and kidney tonifying, the effect of cooling blood for hemostasis, for having a dizzy spell caused by the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Be suitable for the deficiency of YIN and have hot person, be used for the treatment of the haematemesis of accumulated heat in stomach, the cards such as the hemoptysis of injury of blood vessel of the lung by heat.
Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and return spleen, lung meridian, have effect of air making-up and spleen enlivening, the lung moistening and production of body fluid promoting, cure mainly the inappetence caused by deficiency-weakness of spleen-QI, fatigue and weakness, deficiency of the lung cough caused by dryness, dyspnea with rapid and short breath is breathed hard, the convalescent stage of febrile disease, and gas Tianjin two is hindered, and interior-heat is thirsty waits card.
Rhizoma Saururi (Herba Saururi): latin name SaururiHerba, sweet in the mouth, pungent, cold in nature, return lung, urinary bladder channel, there is clearing away heat and promoting diuresis; Effect of removing toxic substances and promoting subsidence of swelling, cures mainly pyretic stranguria; Stranguria with blood; Edema; Foot gas; Jaundice; Dysentery; Leukorrhagia; Carbuncle sore tumefacting virus; Eczema; The cards such as venom.
Ipomoea hungaiensis Lingelsh. Et Borza.: be the root of the wild Semen vignae sinensis of pulse family Vigna plant, sweet in the mouth, hardship, property is put down, and has supplementing QI for promoting the production of body fluid, effect of liyan jiedu, and cure mainly dizzy weak, insomnia, the prolapse of the uterus, proctoptosis, breast is few, summer-heat excessive thirst, acute toothache, laryngopharynx swelling and pain, the cards such as venom.
Rock spring grass: be the herb of Aspleniaceae spleen wort tiger tail Asplenium trchomanes L., bitter in the mouth, sweet, cool in nature, have heat-clearing and toxic substances removing, suppressing the hyperactive liver, effect of diuresis, cures mainly jaundice due to damp-heat, cough due to lung-heat, infantile convulsion, dysuria, the cards such as dactylitis.
Radix Tylophorae arenicolae: the root disappeared for the spirit of asclepiadaceae Cynanchum plant bamboo or aerial parts, bitter in the mouth, micro-pungent, property is put down, and returns lung meridian, has clearing away heat and cooling blood, function of gallbladder promoting, effect of removing toxic substances, cures mainly fever due to yin deficiency, chronic consumptive disease chronic cough, hemoptysis, distending pain over the hypochondrium, vomiting and nausea, dysentery, puerperal fidgets due to deficiency, innominate toxic swelling, snakeworm, mad dog such as to be bitten at the card.
Radix Euryae Chinensis: be stem, the leaf of Theaceae Eurya plant platymiscium Radix Euryae Chinensis, bitter in the mouth, micro-puckery, cool in nature, have removing damp-heat, effect of removing toxic substances sore, cures mainly cold, fever, jaundice due to damp-heat, sore swollen toxin, burn due to hot liquid or fire, rushes venom, the cards such as traumatic hemorrhage.
Fructus Citri Sarcodactylis: acrid in the mouth, hardship, warm in nature, return liver, stomach, lung meridian, there is soothing the liver circulation of qi promoting, and in the effect of reducing phlegm, for the distending pain in the chest and hypochondrium of stagnation of QI due to depression of the liver, incoordination between the liver and stomach, stagnation of QI in spleen and stomach, the cards such as vomiting and nausea lack of appetite.
Herba Solani Lyrati: latin name SolanumlyratumThunb, bitter in the mouth, property is put down, and have clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, anticancer effect, cures mainly cold, fever, icterohepatitis, cholecystitis, cholelithiasis, cancer, uterine erosion, leucorrhea, oedema due to nephritis; External is controlled carbuncle furuncle and phyma poison and is waited card.
Herba Desmodii Styracifolii: sweet in the mouth, light, property is put down, and have clearing heat and removing internal wetness, effect of inducing diuresis for treating stranguria syndrome, cures mainly urinary tract infection, urinary system calculus, cholelithiasis, nephritis edema, jaundice, infantile malnutrition, the cards such as carbuncle.
Caulis Bambusae In Taenia: cold nature, sweet in the mouth, attaches to the lung and stomach meridians, and has removing heat-phlegm, the effect relieved restlessness and prevented vomiting, and holds the card such as expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.
Radix Curcumae: acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian, there is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice, cure mainly amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, the cards such as epilepsy is gone mad, jaundice dark coloured urine.
Medicine provided by the invention is endo-medicine, can be prepared into pharmaceutically acceptable any dosage form as required, preferably be prepared into decoction liquor, powder, electuary, granule, tablet, capsule, be preferably prepared into capsule further.
The present invention also provides said medicine as the preparation method of capsule, specifically comprises:
The first step, puts into pulverizer grinding and sieving by described each crude drug;
Second step, puts into ethanol heating and refluxing extraction 2 times, merge extractive liquid, by the particulate matter be left after sieving;
3rd step, then get the medicinal residues after above-mentioned ethanol extraction, the heating and refluxing extraction that adds water 2 times, merge extractive liquid;
4th step, two kinds of extracting solution second step and the 3rd step obtained merge, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
The described first step is specially further, and put into by described raw material after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collects by the raw material fine powder of 100 mesh sieves for subsequent use;
In described second step, putting into relative to its volume 2 ~ 4 times of determining alcohols by the particulate matter be left after sieving is 70% ~ 80% ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by 2 extracting solution and leaves standstill, obtain the first extracting solution.
In described 3rd step, the medicinal residues crossed by ethanol extraction in second step add and extract 2 times relative to its volume 4 ~ 6 times of water gagings heating 1 ~ 2 hours reflux; Above-mentioned 2 extracting solution are merged and leaves standstill, obtain the second extracting solution.
In described 4th step, above-mentioned first extracting solution and the second extracting solution are merged, when concentrating under reduced pressure relative density is 50 DEG C 1.05 filtrate, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 80 DEG C, obtains raw material medicated powder, and the raw material medicated powder that the raw material fine powder obtained after the first step being sieved and the 4th step obtain mixes and incapsulates.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 capsule
By Herba Artemisiae Scopariae 25g, Radix Et Rhizoma Rhei 19g, Poria 15g, Fructus Aurantii Immaturus 15g, Radix Gentianae 22g, Myrrha 15g, Radix Liriopes 23g, Herba Ecliptae 17g, Rhizoma Polygonati 25g, Radix Pseudostellariae 33g, Rhizoma Saururi (Herba Saururi) 17g, Ipomoea hungaiensis Lingelsh. Et Borza. 20g, rock spring grass 23g, Radix Tylophorae arenicolae 25g, Radix Euryae Chinensis 19g, Fructus Citri Sarcodactylis 27g, Herba Solani Lyrati 25g, Herba Desmodii Styracifolii 27g, Caulis Bambusae In Taenia 25g and Radix Curcumae 28g puts into after pulverizer is pulverized and crosses 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collect for subsequent use by the raw material fine powder of 100 mesh sieves, putting into relative to its volume 3 times of determining alcohols by the particulate matter be left after sieving is 80% ethanol heating and refluxing extraction 2 times, each 2 hours, 2 extracting solution are merged and leaves standstill, obtain the first extracting solution, the medicinal residues crossed by ethanol extraction add and heat 2 hours reflux relative to its volume 5 times of water gagings and extract 2 times, 2 extracting solution are merged and leaves standstill, obtain the second extracting solution, first extracting solution and the second extracting solution are merged, when concentrating under reduced pressure relative density is 50 DEG C 1.05 filtrate, pass into spray dryer and carry out spraying dry, the compressed air pressure crossing spray dryer shower nozzle is 4kg/m
2, hothouse hot stream temperature is 80 DEG C, obtains raw material medicated powder, and mixed with the raw material medicated powder that the 4th step obtains by the raw material fine powder obtained after sieving above and incapsulate, the weight of every capsules is 0.5g.
The acute toxicity test of Chinese medicine capsules
The Chinese medicine capsules provided by embodiment 1 to ICR Strains of Mouse gavage, does not all measure LD respectively
50, administration 2 times in 24 hours, observes 14 days, and mice is all without dead, and its maximum test medicine amount is 61.4g/kg, is about 345.6 times that clinical people intends consumption, under this dosage, does not observe any toxic reaction.
The long term toxicity test of Chinese medicine capsules
Six months long term toxicity tests: respectively with the Chinese medicine capsules provided in embodiment 1 to rat oral gavage, consumption is equivalent to 80,40,20 times of the clinical plan consumption of people.Observation item comprises General observation and complete observation, and Detection of content has hematological examination 12, blood borne chemical examination 15 and organ index and histopathologic examination 29.Result Hair of Rat coloured light is clean, and behavioral activity, glandular secretion, breathing, feces character are all normal, and body weight generally increases, and hematological examination, blood biochemical analysis inspection and organ index and pathological examination are all normal, prove that this product belongs to nontoxic level.
The long-term stable experiment of Chinese medicinal tablet
The Chinese medicine capsules provided in Example 1, by commercially available back, storage 24 months under the room temperature storehouse condition meeting GSP requirement, every Index for examination i.e. 0 month measurement result more equal no significant difference front with test, indices all meets statutory standards, illustrates that this product has good stability.
Embodiment 2 animal experiment
Anti-inflammatory effects
Get healthy ICR mice 60, male and female half and half, divide 2 groups, 30/group, i.e. model group and Chinese drug-treated group of the present invention.The capsule of every oral administration embodiment 1 dissolves the solution made 1 time/d, 1g (crude drug)/kg, administration 14d, 60min after last medicine, mouse right ear uniform application dimethylbenzene 0.03mL/ only causes swollen, cuts ears and beat auricle and weigh after 2h, calculates ear swelling value (mg).Swelling value=auris dextra weight-left ear weight, the results are shown in Table 1.
Statistical analysis
—
Applied statistics software SPSS (edition17.0) carries out statistical analysis, data represent with X ± s (average ± standard deviation), measurement data unary variance analysis, between group, difference t checks, P<0.05 is that difference has significance, and P<0.01 is significant differences.
The impact of table 1 Chinese medicine xylol of the present invention induced mice ear swelling
| Group | Ear swelling value (mg) |
| Model group | 11.75+2.63 |
| Chinese drug-treated group | 6.28+1.02 * |
Note: compare with model group,
*p<0.01
Result shows, compare with model group, medicine of the present invention significantly can reduce the ear swelling value (P < 0.01) of dimethylbenzene induced mice, show that Chinese medicine composition of the present invention has the effect of the mice ear significantly suppressing dimethylbenzene induction, and it exists significant dose-effect relationship to the reduction effect of ear swelling, anti-inflammatory effects is good.
Embodiment 3 clinical data
My institute accepts chronic cholecystitis patient 150 example altogether for medical treatment from October, 2013 ~ 2014 year JIUYUE and is divided into 2 groups at random, matched group 75 example, man 43 example, female 32 example; Age, 43.6 years old mean age, treatment group 75 was routine at 23 ~ 69 years old, man 40 example, female 35 example; Age, 45.8 years old mean age, 2 groups of state of an illness, the course of disease, sex, the age, there was no significant difference, had comparability through statistical procedures at 25 ~ 71 years old.
Diagnostic criteria
TCM syndrome diagnostic criteria
In this patients all, the patient belonging to retention of damp-heat in the interior pattern of syndrome is selected about the diagnostic criteria of syndrome of dampness-heat of liver and gallbladder with reference in " Chinese Internal Medicine " 5 editions teaching materials.Diagnostic criteria is as follows: primary symptom: persistence hypochondriac pain, and more so, neglect and heavily neglect gently, pain draws the right back of the body, and bitter taste is uncomfortable in chest, stringy pulse on right side.Secondary disease: generate heat thirsty, or fever with aversion to cold, loss of appetite, bitter taste in the mouth and dry throat, tending to vomit of feeling sick, yellowish fur, rapid pulse.
Western medicine diagnose standard
" new Chinese medicine treatment guideline of clinical investigations " developed and published with reference to National Drug Administration (2002 May the 1st edition) is diagnosed all selected patients.Diagnostic criteria is as follows: 1. upper right abdomen persistence dull pain, discomfort, or omoplate district pain; 2. with feeling sick, the dyspeptic symptom such as belch, pantothenic acid, abdominal distention and scorching hot, above-mentioned symptom can in the postemphasis of patients diet's greasy food; 3. the course of disease is longer, and has the advantages that acute attack and remission alternately occur; 4. there are slight tenderness sense or percussion pain in gallbladder area; 5. thicken through the visible gallbladder wall of color ultrasound examination is crude, gallbladder reduces or is out of shape; 6. reduce through the visible gallbladder of gallbladder examination or be out of shape, the development of the contractile function of gallbladder bad or gallbladder thin (note: allly to possess 5., 6. two one of them, add 1. ~ 4. four two persons wherein, can make its state of an illness and clarifying a diagnosis).
With reference to the B ultrasonic diagnostic criteria in Ministry of Public Health " new Chinese medicine guideline of clinical investigations ", all selected patients are diagnosed.Diagnostic criteria is as follows: the first stage: the shape of blister cavities and gallbladder, size Non Apparent Abnormality, or with the situation that gallbladder wall slightly thickens, or have calculus in gallbladder.Second stage: gollbladder dilation, cyst wall thickens > 0.3cm, and it is broadening that the lighter shows as cyst wall echo zone, and dark hypoecho layer can appear in severe one.Phase III: gallbladder wall significantly thickens (proliferous type), cyst wall thickens and can reach 1.5cm, shows medium or more weak echo, and mucosa chamber significantly reduces, and mucous membrane surface is more complete; Gallbladder reduces (atrophic type), and blister cavities narrows, and can be full of calculus and show " WES " to levy in it.
Therapeutic Method
Matched group: give erythromycin: 0.3g, every day 4 times, taking medicine after meal; XIAOYAN LIDAN PIAN 3 ~ 5, every day 3 times is oral, and serveing on 15d is 1 course for the treatment of.Treatment group adds the capsule treatment prepared by embodiment 1 on this basis, every day 2 times, and each 3, one after each meal sooner or later, two groups for the treatment of times are 2 courses for the treatment of.
Statistical analysis
—
Applied statistics software SPSS (edition17.0) carries out statistical analysis, data represent with X ± s (average ± standard deviation), measurement data unary variance analysis, between group, difference t checks, P<0.05 is that difference has significance, and P<0.01 is significant differences.
Result
Two groups of patient clinical comparitive study, the results are shown in Table 2.
Table 2 liang group patient clinical comparitive study
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate |
| Treatment group | 75 | 32 | 17 | 23 | 3 | 96.0％ * |
| Matched group | 75 | 20 | 23 | 16 | 16 | 78.6％ |
Note: compare with matched group,
*p<0.01
As can be seen from Table 2, adopt medicine capsule provided by the invention to coordinate traditional therapy, better can improve the therapeutic effect of chronic cholecystitis, compared with matched group, significant difference, P<0.01.
Chinese medicine syndrome integral before and after two groups of patient treatments compares, and the results are shown in Table 3.
A table 3 liang group patient Chinese medicine syndrome integral compares
| Group | n | Before treatment | After treatment |
| Treatment group | 75 | 15.13+2.66 | 3.95+1.02 * |
| Matched group | 75 | 14.79+2.97 | 8.83+2.01 |
Note: compare with matched group,
*p<0.01
As can be seen from Table 3, Chinese medicine syndrome integral before and after medicine capsule provided by the invention treatment is adopted to change comparatively matched group more obvious, two groups of significant differences, P<0.01.
Before and after two groups of patient treatments, color ultrasound change is compared, and the results are shown in Table 4.
Before and after table 4 liang group patient treatment, color ultrasound change is compared
| Group | Before treatment | After treatment | ||||
| First stage | Second stage | Phase III | First stage | Second stage | Phase III | |
| Treatment | 13 | 39 | 23 | 36 | 28 | 11 |
| Contrast | 11 | 41 | 23 | 19 | 36 | 20 |
Table 4 can be found out, the gallbladder color ultrasound situation of change for the treatment of group patient will significantly better than matched group.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. be used for the treatment of a medicine for chronic cholecystitis, it is characterized in that: crude drug comprises Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Poria, Fructus Aurantii Immaturus, Radix Gentianae, Myrrha, Radix Liriopes, Herba Ecliptae, Rhizoma Polygonati, Radix Pseudostellariae, Rhizoma Saururi (Herba Saururi), Ipomoea hungaiensis Lingelsh. Et Borza., rock spring grass, Radix Tylophorae arenicolae, Radix Euryae Chinensis, Fructus Citri Sarcodactylis, Herba Solani Lyrati, Herba Desmodii Styracifolii, Caulis Bambusae In Taenia and Radix Curcumae.
2. be used for the treatment of the medicine of chronic cholecystitis as claimed in claim 1, it is characterized in that: in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 23 weight portion ~ 28 weight portion, Radix Et Rhizoma Rhei 17 weight portion ~ 22 weight portion, Poria 13 weight portion ~ 18 weight portion, Fructus Aurantii Immaturus 13 weight portion ~ 18 weight portion, Radix Gentianae 20 weight portion ~ 25 weight portion, Myrrha 13 weight portion ~ 18 weight portion, Radix Liriopes 21 weight portion ~ 26 weight portion, Herba Ecliptae 15 weight portion ~ 20 weight portion, Rhizoma Polygonati 23 weight portion ~ 28 weight portion, Radix Pseudostellariae 31 weight portion ~ 36 weight portion, Rhizoma Saururi (Herba Saururi) 15 weight portion ~ 20 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 18 weight portion ~ 23 weight portion, rock spring grass 21 weight portion ~ 26 weight portions, Radix Tylophorae arenicolae 23 weight portion ~ 28 weight portion, Radix Euryae Chinensis 17 weight portion ~ 22 weight portion, Fructus Citri Sarcodactylis 25 weight portion ~ 30 weight portion, Herba Solani Lyrati 23 weight portion ~ 28 weight portion, Herba Desmodii Styracifolii 25 weight portion ~ 30 weight portion, Caulis Bambusae In Taenia 23 weight portion ~ 28 weight portion and Radix Curcumae 26 weight portion ~ 31 weight portion.
3. be used for the treatment of the medicine of chronic cholecystitis as claimed in claim 1 or 2, it is characterized in that: in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 24 weight portion ~ 27 weight portion, Radix Et Rhizoma Rhei 18 weight portion ~ 21 weight portion, Poria 14 weight portion ~ 17 weight portion, Fructus Aurantii Immaturus 14 weight portion ~ 17 weight portion, Radix Gentianae 21 weight portion ~ 24 weight portion, Myrrha 14 weight portion ~ 17 weight portion, Radix Liriopes 22 weight portion ~ 25 weight portion, Herba Ecliptae 16 weight portion ~ 19 weight portion, Rhizoma Polygonati 24 weight portion ~ 27 weight portion, Radix Pseudostellariae 32 weight portion ~ 35 weight portion, Rhizoma Saururi (Herba Saururi) 16 weight portion ~ 19 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 19 weight portion ~ 22 weight portion, rock spring grass 22 weight portion ~ 25 weight portions, Radix Tylophorae arenicolae 24 weight portion ~ 27 weight portion, Radix Euryae Chinensis 18 weight portion ~ 21 weight portion, Fructus Citri Sarcodactylis 26 weight portion ~ 29 weight portion, Herba Solani Lyrati 24 weight portion ~ 27 weight portion, Herba Desmodii Styracifolii 26 weight portion ~ 29 weight portion, Caulis Bambusae In Taenia 24 weight portion ~ 27 weight portion and Radix Curcumae 27 weight portion ~ 30 weight portion.
4. the medicine being used for the treatment of chronic cholecystitis as described in claims 1 to 3, it is characterized in that: in described medicine, the weight portion of each crude drug is respectively Herba Artemisiae Scopariae 25 weight portion, Radix Et Rhizoma Rhei 19 weight portion, Poria 15 weight portion, Fructus Aurantii Immaturus 15 weight portion, Radix Gentianae 22 weight portion, Myrrha 15 weight portion, Radix Liriopes 23 weight portion, Herba Ecliptae 17 weight portion, Rhizoma Polygonati 25 weight portion, Radix Pseudostellariae 33 weight portion, Rhizoma Saururi (Herba Saururi) 17 weight portion, Ipomoea hungaiensis Lingelsh. Et Borza. 20 weight portion, rock spring grass 23 weight portions, Radix Tylophorae arenicolae 25 weight portion, Radix Euryae Chinensis 19 weight portion, Fructus Citri Sarcodactylis 27 weight portion, Herba Solani Lyrati 25 weight portion, Herba Desmodii Styracifolii 27 weight portion, Caulis Bambusae In Taenia 25 weight portion and Radix Curcumae 28 weight portion.
5. the medicine being used for the treatment of chronic cholecystitis as described in Claims 1-4, is characterized in that: described medicine is endo-medicine.
6. the medicine being used for the treatment of chronic cholecystitis as described in claim 1 to 5, is characterized in that: described medicine is prepared into decoction liquor, powder, electuary, granule, tablet, capsule.
7. the preparation method of medicine described in claim 1 to 6, is characterized in that, comprising:
The first step, puts into pulverizer grinding and sieving by described each crude drug;
Second step, puts into ethanol heating and refluxing extraction 2 times, merge extractive liquid, by the particulate matter be left after sieving;
3rd step, then get the medicinal residues after above-mentioned ethanol extraction, the heating and refluxing extraction that adds water 2 times, merge extractive liquid;
4th step, two kinds of extracting solution second step and the 3rd step obtained merge, decompression recycling ethanol spraying dry, obtain medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.
8. the preparation method of medicine as claimed in claim 7, it is characterized in that: the described first step is specially further, put into by described raw material after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 mesh sieves is reaching 50%, collects by the raw material fine powder of 100 mesh sieves for subsequent use.
9. the preparation method of medicine as claimed in claim 7, it is characterized in that: in described second step, putting into relative to its volume 2 ~ 4 times of determining alcohols by the particulate matter be left after sieving is 70% ~ 80% ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, obtain the first extracting solution.
10. the preparation method of medicine as claimed in claim 7, is characterized in that: in described 3rd step, and the medicinal residues crossed by ethanol extraction in second step add and extract 2 times relative to its volume 4 ~ 6 times of water gagings heating 1 ~ 2 hours reflux; Above-mentioned 2 extracting solution are merged and leaves standstill, obtain the second extracting solution.
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Citations (1)
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| CN103007234A (en) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation |
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| CN103007234A (en) * | 2012-12-28 | 2013-04-03 | 青岛华仁信息技术开发有限公司 | Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation |
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Application publication date: 20151216 |