CN104689151A - Traditional Chinese medicine composition for treating diabetes and use of composition - Google Patents
Traditional Chinese medicine composition for treating diabetes and use of composition Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicine composition for treating diabetes and use of composition. The traditional Chinese medicine composition is mainly prepared from the following raw materials: radices trichosanthis, radix scrophulariae, fried rhizoma atractylodis, ligusticum wallichii, fried semen coicis, fried Chinese yam, schisandra chinensis, dogwood and poria. The traditional Chinese medicine composition provided by the invention is remarkable in curative effect on diabetes, particularly diabetes induced by extreme heat with yin asthenia, so that the living quality of the patient can be obviously improved and the traditional Chinese medicine composition is free of remarkable toxic and side effects.
Description
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition for the treatment of diabetes and uses thereof.
Background technology
Diabetes are a kind of incretion metabolism diseases, be due to insulin in body relatively or definitely not enough and carbohydate metabolism that is that cause is disorderly, cause the disease of the water and electrolyte metabolism disorder of sugar, protein, fat and secondary.Diabetes divide two types clinically: insulin dependent diabetes mellitus (IDDM) (i.e. type i diabetes), non-insulin-dependent diabetes mellitus (i.e. type ii diabetes).
Current treatment diabetes, except positive mode of making the life better (control calorie diet, the selection on basis are reasonably moved), the treatment of oral antidiabetic drug and the application of insulin, also have the transplanting etc. of pancreatic stem cell.Although the prevention and controls of diabetes is more and more abundanter, also all have respective advantage, most action target spot is single, metabolic pathway is different, may develop immunity to drugs, the hepatorenal damage even side effect such as hypoglycemia, drug allergy.
The administering mode of Chinese medicine personalization, composition of prescription etc. flexibly, the negative and positive of qi and blood of human body self can be regulated to the full extent to balance, reach the object of self-regeneration, thus improving clinical symptoms, improve glycolipid metabolism, lose weight, alleviate in insulin resistant etc. and play a role, there is the advantage that doctor trained in Western medicine is incomparable.
Summary of the invention
In order to overcome prior art deficiency, the invention provides a kind of Chinese medicine composition for the treatment of diabetes, this Chinese medicine composition good effect, side effect is little, and it obtains primarily of following raw material: Radix Trichosanthis, Radix Scrophulariae, Rhizoma Atractylodis (parched), Rhizoma Chuanxiong, Semen Coicis (parched), Rhizoma dioscoreae (parched), Fructus Schisandrae Chinensis, Fructus Corni, Poria.
Radix Trichosanthis, sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Radix Scrophulariae, sweet, bitter, salty, be slightly cold.Return lung, stomach, kidney channel.Removing heat from blood YIN nourishing, eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Rhizoma Atractylodis (parched), pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Rhizoma Atractylodis: removing impurity, clean, run through, cut sheet, dry.Parched with bran Rhizoma Atractylodis: get Rhizoma Atractylodis sheet, fry to surperficial buff according to parched with bran method (appendix II D).This product is similar round or bar shaped sheet, and ash must not consider to be worth doing 3% (annex Ⅸ B).
The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.
Semen Coicis (parched) is sweet, light, cool.Return spleen, stomach, lung meridian.Spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.Semen Coicis: removing impurity.Semen Coicis (parched with bran): get clean Semen Coicis, fries to micro-yellow according to parched with bran method (appendix II D).
Rhizoma Dioscoreae, sweet; Flat lung; Spleen; Kidney channel spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Main diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula.Rhizoma Dioscoreae: pick decontamination, be soaked in water to Rhizoma Dioscoreae central part and soften as degree, pull out and slightly dry in the air, section is dried or is dried.Rhizoma dioscoreae (parched): first by even for wheat bran spreading in hot pot, cigarette of waiting rises, add yam slice stir to faint yellow for degree, take out, sieve remove wheat bran, cool (every yam slice 100, with 10 jin, wheat bran).
Fructus Schisandrae Chinensis, is commonly called as Fructus Zanthoxyli Plansipini, sliding weight of steelyard, medicine Fructus Schisandrae Chinensis, face rattan, five Fructus Armeniacae Mumes etc., Tang etc. " Newly Revised Canon of Materia Medica " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, it is top grade to list in Sheng Nong's herbal classic the earliest, and herbal function is the power of strengthening by means of tonics, and medical value is high, and it has astringes the lung, and nourishing kidney, promotes the production of body fluid, receipts antiperspirant, effect of arresting seminal emission.
Fructus Corni, sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Poria, is commonly called as Poria, and sweet in the mouth, light, property are put down, and enter the heart, lung, spleen channel.Be used as medicine and there is the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.
Preferably, also Fructus Citri and Fructus Amomi is contained further in Chinese medicine composition of the present invention.Fructus Citri has another name called citron, is Rutaceae citrus plant, and Fructus Citri acrid in the mouth, micro-hardship, acid are warm in nature; Return liver, lung, spleen channel; Gas perfume row is loose, can rise and can fall; Have depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, dehumidifying and in effect, cure mainly distending pain in the chest and hypochondrium, cough with copious phlegm, gastral cavity abdomen painful abdominal mass pain, dyspepsia vomiting, edema beriberi.Fructus Amomi, pungent, temperature.Return spleen, stomach, kidney channel.Removing dampness is whetted the appetite, warming spleen and stopping diarrha, regulates the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing for the treatment of diabetes effect.As a preferred embodiment of the present invention, Chinese medicine composition of the present invention obtains primarily of the crude drug of following weight portion: Radix Trichosanthis 7-9 part, Radix Scrophulariae 11-13 part, Rhizoma Atractylodis (parched) 17-19 part, Rhizoma Chuanxiong 14-16 part, Semen Coicis (parched) 6-8 part, Rhizoma dioscoreae (parched) 7-9 part, Fructus Schisandrae Chinensis 6-9 part, Fructus Corni 9-11 part, Poria 9-11 part.Further preferably, Chinese medicine composition of the present invention is also containing, for example the crude drug of lower weight portion: Fructus Citri 5 parts and Fructus Amomi 7 parts.
Further preferably, Chinese medicine composition of the present invention obtains primarily of the crude drug of following weight portion: Radix Trichosanthis 8 parts, Radix Scrophulariae 12 parts, Rhizoma Atractylodis (parched) 18 parts, Rhizoma Chuanxiong 15 parts, Semen Coicis (parched) 7 parts, Rhizoma dioscoreae (parched) 8 parts, Fructus Schisandrae Chinensis 8 parts, Fructus Corni 10 parts, Poria 10 parts, Fructus Citri 5 parts and Fructus Amomi 7 parts.
For diabetes, with Radix Trichosanthis, Radix Scrophulariae enriching yin and nourishing kidney in we, to fry pale art, Semen Coicis (parched), Fructus Amomi, Poria replenishing QI to invigorate the spleen help fortune; Fructus Corni, Fructus Schisandrae Chinensis, Rhizoma dioscoreae (parched) arresting seminal emission solid-liquid, Fructus Citri depressed liver-energy dispersing and QI regulating, Rhizoma Chuanxiong is ignited descending, blood circulation promoting and blood stasis dispelling.Full side's nourishing YIN and clearing away heat, spleen invigorating fortune, can arresting seminal emission solid-liquid, blood circulation promoting and blood stasis dispelling, thus plays the remarkable result of blood sugar lowering, glucose in urine.We's change plus-minus is flexibly, accurately dialectical, and clinical practice curative effect certainly.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, powder, pill, sublimed preparation, unguentum, granule, tablet, capsule.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into capsule or tablet.
Present invention also offers a kind of preparation method preparing above-mentioned Chinese medicinal composition capsules agent, it mainly comprises following step: first, get Radix Trichosanthis, Radix Scrophulariae, Rhizoma Atractylodis (parched), Rhizoma Chuanxiong, Semen Coicis (parched), Rhizoma dioscoreae (parched), Fructus Schisandrae Chinensis, Fructus Corni, Poria, Fructus Citri and Fructus Amomi are broken into coarse powder, according to 6 times of soak by water 2 times of coarse powder gross weight, each 2 hours, merge decoction liquor, adding ethanol to concentration is 60%, place 24 hours, filter, alcohol deposit fluid decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, add appropriate amount of auxiliary materials mixing again, capsule is prepared into conventional fabrication process.Described adjuvant can be white vaseline, glyceryl monostearate, stearic acid.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment diabetes medicament.Test examples 7 of the present invention shows, and Chinese medicine composition Chinese medicine composition of the present invention exists significant synergism in treating diabetes, each group of Chinese medicine composition compared with pioglitazone reduction fasting glucose and 2h-plasma glucose in effect better.Be embodied in: no matter (1) is fasting glucose or 2h-plasma glucose, pioglitazone group and I, II, III, IV group, Chinese medicine have significant difference with model group, and Chinese drug-treated group compares with model group pole significant difference; (2) compared with pioglitazone group, each group of Chinese medicine has pole significant difference in reduction fasting glucose; (3) compared with pioglitazone group, I, III, IV group, Chinese medicine has significant difference in reduction 2h-plasma glucose, and II group, Chinese medicine has pole significant difference compared with pioglitazone group; (4) compared with I group, Chinese medicine, IV group, Chinese medicine has significant difference in reduction fasting glucose and 2h-plasma glucose, and II group, Chinese medicine has pole significant difference.In a word, the present invention compared with prior art has clear superiority.
In clinical observation process, treatment group efficacy result is as follows: effective 40 examples (66.7%), effective 17 examples (28.3%), invalid 3 examples (5.0%), total effective rate 95.0%; Effective 21 examples (35.0%) of matched group, effective 29 examples (48.3%), invalid 10 examples (16.7%), total effective rate 83.3%.Between two groups, total effective rate compares, and treatment group is apparently higher than matched group.In addition, have clear improvement before all comparatively treating after the indexs such as treatment group fasting glucose, 2h-plasma glucose, 24h glucose in urine are quantitative treatment, all have highly significant gender gap (P < 0.01) through statistical test (t inspection); Matched group indices also has certain improvement, but fall is less, has significant difference (P < 0.05) compared with treatment group.In treatment group therapeutic process, vital sign steadily and without serious adverse reactions such as allergy, show that the clinical application of we is safely and effectively.Therefore, compared with prior art, pharmaceutical composition of the present invention has clear superiority, is worth studying and applying further.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
EXAMPLE l
Each raw material is taken: Radix Trichosanthis 8 parts, Radix Scrophulariae 12 parts, Rhizoma Atractylodis (parched) 18 parts, Rhizoma Chuanxiong 15 parts, Semen Coicis (parched) 7 parts, Rhizoma dioscoreae (parched) 8 parts, Fructus Schisandrae Chinensis 8 parts, Fructus Corni 10 parts, Poria 10 parts by following weight portion.
Get Radix Trichosanthis, Radix Scrophulariae, Rhizoma Atractylodis (parched), Rhizoma Chuanxiong, Semen Coicis (parched), Rhizoma dioscoreae (parched), Fructus Schisandrae Chinensis, Fructus Corni, Poria be broken into coarse powder, according to 6 times of soak by water 2 times of coarse powder gross weight, each 2 hours, merge decoction liquor, adding ethanol to concentration is 60%, place 24 hours, filter, alcohol deposit fluid decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds appropriate white vaseline, glyceryl monostearate, stearic acid and distilled water, conveniently preparation technology is prepared into capsule, and every capsules is containing crude drug 0.4g.
Embodiment 2
Each raw material is taken: Radix Trichosanthis 9 parts, Radix Scrophulariae 13 parts, Rhizoma Atractylodis (parched) 19 parts, Rhizoma Chuanxiong 16 parts, Semen Coicis (parched) 8 parts, Rhizoma dioscoreae (parched) 9 parts, Fructus Schisandrae Chinensis 9 parts, Fructus Corni 11 parts, Poria 11 parts by following weight portion.
Preparation method is with embodiment 1.
Embodiment 3
Each raw material is taken: Radix Trichosanthis 7 parts, Radix Scrophulariae 11 parts, Rhizoma Atractylodis (parched) 17 parts, Rhizoma Chuanxiong 14 parts, Semen Coicis (parched) 6 parts, Rhizoma dioscoreae (parched) 7 parts, Fructus Schisandrae Chinensis 6 parts, Fructus Corni 9 parts, Poria 9 parts by following weight portion.
Get Radix Trichosanthis, Radix Scrophulariae, Rhizoma Atractylodis (parched), Rhizoma Chuanxiong, Semen Coicis (parched), Rhizoma dioscoreae (parched), Fructus Schisandrae Chinensis, Fructus Corni, Poria be broken into coarse powder, according to 6 times of soak by water 2 times of coarse powder gross weight, each 2 hours, merge decoction liquor, adding ethanol to concentration is 60%, places 24 hours, filters, alcohol deposit fluid decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds appropriate amount of auxiliary materials, conveniently preparation technology is prepared into tablet, and every sheet is containing crude drug 0.4g.
Embodiment 4
Each raw material is taken: Radix Trichosanthis 8 parts, Radix Scrophulariae 12 parts, Rhizoma Atractylodis (parched) 18 parts, Rhizoma Chuanxiong 15 parts, Semen Coicis (parched) 7 parts, Rhizoma dioscoreae (parched) 8 parts, Fructus Schisandrae Chinensis 8 parts, Fructus Corni 10 parts, Poria 10 parts, Fructus Citri 5 parts and Fructus Amomi 7 parts by following weight portion.
Get Radix Trichosanthis, Radix Scrophulariae, Rhizoma Atractylodis (parched), Rhizoma Chuanxiong, Semen Coicis (parched), Rhizoma dioscoreae (parched), Fructus Schisandrae Chinensis, Fructus Corni, Poria, Fructus Citri and Fructus Amomi and be broken into coarse powder, according to 6 times of soak by water 2 times of coarse powder gross weight, each 2 hours, merge decoction liquor, adding ethanol to concentration is 60%, place 24 hours, filter, alcohol deposit fluid decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, adds appropriate white vaseline, glyceryl monostearate, stearic acid and distilled water, conveniently preparation technology is prepared into capsule, and every capsules is containing crude drug 0.4g.
Embodiment 5
Each raw material is taken: Radix Trichosanthis 7 parts, Radix Scrophulariae 11 parts, Rhizoma Atractylodis (parched) 17 parts, Rhizoma Chuanxiong 14 parts, Semen Coicis (parched) 6 parts, Rhizoma dioscoreae (parched) 7 parts, Fructus Schisandrae Chinensis 6 parts, Fructus Corni 9 parts, Poria 9 parts, Fructus Citri 5 parts and Fructus Amomi 7 parts by following weight portion.
Preparation method is with embodiment 4.
Embodiment 6
Each raw material is taken: Radix Trichosanthis 9 parts, Radix Scrophulariae 13 parts, Rhizoma Atractylodis (parched) 19 parts, Rhizoma Chuanxiong 16 parts, Semen Coicis (parched) 8 parts, Rhizoma dioscoreae (parched) 9 parts, Fructus Schisandrae Chinensis 9 parts, Fructus Corni 11 parts, Poria 11 parts, Fructus Citri 5 parts and Fructus Amomi 7 parts by following weight portion.
Preparation method is with embodiment 4.
Embodiment 7: Chinese medicine composition of the present invention causes the therapeutical effect of diabetes rat model to streptozotocin
Body weight 160 ~ 180gWistar rat, male and female half and half, first feed with high-sugar-fat-diet (albumen selects matter 5%, carbohydrate 60%, and wherein sucrose is 30%, fatty 32%, and wherein refining Adeps Sus domestica is 30%) after 4 weeks, Rat Fast 18h.Lumbar injection 0.6% streptozotocin (STZ) 30mg/kg, STZ are dissolved in pH4.0, and in 0.1mol/L citric acid-sodium citrate buffer, each dose is finished in 10min.Blank group rats by intraperitoneal injection equal-volume citric acid-sodium citrate buffer, normally raises.Within 5 days, dock afterwards and get blood survey whole blood sugar, with blood glucose value horizontal > 10.0mmol/L person for modeling success.
Modeling success rat is divided into model control group, pioglitazone group, I, II, III, IV group totally 6 groups, Chinese medicine composition Chinese medicine at random according to blood sugar level, often organizes 10.Each group gives following medicine respectively:
Model control group: gavage gives equal-volume normal saline;
Pioglitazone group: gavage gives pioglitazone 2.5mg/kgd;
I group, Chinese medicine: it is the Chinese medicinal composition capsules agent of 0.4g/kgd that gavage gives crude drug amount prepared by embodiment 1;
II group, Chinese medicine: it is the Chinese medicinal composition capsules agent of 0.4g/kgd that gavage gives crude drug amount prepared by embodiment 4;
III group, Chinese medicine: it is the Chinese medicinal composition capsules agent of 0.1g/kgd that gavage gives crude drug amount prepared by embodiment 5;
IV group, Chinese medicine: the crude drug amount that gavage gives embodiment 6 preparation is the agent of 1.0g/kgd Chinese medicinal composition capsules.
Above-mentioned administration group is administered once every day, according to dosage gastric infusion, continuous 10 weeks, normally raises.All rats detect fasting glucose (FBG), 2h blood glucose (PBG) after feed respectively at getting weekly tail vein in 4 weeks before treatment and after treatment.The blood sample of taking-up is put into protein precipitant, and after room temperature places 7min, centrifugal 5min (3000r/min), gets supernatant, surveys whole blood sugar with glucose oxidase method.Chinese medicine composition of the present invention on the impact of blood glucose in diabetic rats, in table 1.
Table 1 Chinese medicine composition of the present invention is on the impact of 2h blood glucose after diabetes rat fasting glucose and feed
*compare with model group, P < 0.05,
*compare with model group, P < 0.01;
#compare with pioglitazone group, P < 0.05,
##compare with pioglitazone group, P < 0.01;
☆compare with I group, Chinese medicine, P < 0.05,
☆ ☆compare with I group, Chinese medicine, P < 0.01.
Above-mentioned experimental result shows, each group of Chinese medicine composition compared with pioglitazone reduction fasting glucose and 2h-plasma glucose in effect better.Be embodied in: no matter (1) is fasting glucose or 2h-plasma glucose, pioglitazone group and I, II, III, IV group, Chinese medicine have significant difference with model group, and Chinese drug-treated group compares with model group pole significant difference.(2) compared with pioglitazone group, each group of Chinese medicine has pole significant difference in reduction fasting glucose.(3) compared with pioglitazone group, I, III, IV group, Chinese medicine has significant difference in reduction 2h-plasma glucose, and II group, Chinese medicine has pole significant difference compared with pioglitazone group.(4) compared with I group, Chinese medicine, IV group, Chinese medicine has significant difference in reduction fasting glucose and 2h-plasma glucose, and II group, Chinese medicine has pole significant difference.
The clinical observation of embodiment 8 medicine composite for curing diabetes of the present invention
1, case-data: that selects hospital ward and outpatient clinic meets intense heat due to deficiency of YIN diabetes mellitus type 120 example, more than 45 years old age; Be inclined to without ketoacidosis; Without serious liver, kidney, the heart, brain illness; Do not use insulinize.Meet the Yin Xu Nei Re Zheng diagnostic criteria (with reference to " diabetes (diabetes) guideline of clinical investigations treated by new drug (Chinese medicine) ") of traditional Chinese medical science diabetes: main symptom: 1. thirst with desire to drink, 2. polyorexia, pollakiuria of 3. urinating is many; Secondary card: it is vexed that 1. To Be Protected from Heat, 2. being irritable and getting angry easily, 8. constipation with dry stool.Tongue arteries and veins: red tongue, yellow fur or few; Stringy and thready pulse or stringy and rolling pulse.Possess main symptom 2 double card 2 persons, can make a definite diagnosis with reference to above-mentioned tongue arteries and veins.
Be divided into treatment group, matched group at random.Wherein, treatment group: in 60 routine patients, man 39 example, female 21 example; The oldest 73 years old, minimum 45 years old, course of disease 1-10.5.Matched group: in 60 routine patients, man 40 example, female 20 example; The oldest 74 years old, minimum 45 years old, course of disease 1-10.The physical data there was no significant differences such as two groups of Genders, age, courses of disease, have comparability.
2, usage and dosage:
Treatment group: take medicine composite for curing of the present invention, capsule prepared by Example 5, every containing crude drug amount 0.4g, every day 3 times, each 3-4 grain, after meal half an hour warm water delivery service.
Matched group: the oral ball that more disappears before the meal, each 10g, every day 3 times.(ball that more disappears forms: Radix Astragali 30g, Radix Puerariae 15g, Radix Trichosanthis 30g, the each 15g of raw Radix Rehmanniae Preparata, Radix Scrophulariae 20g, fries grey, each 15g of the Rhizoma Atractylodis Macrocephalae, Poria 20g, Semen Coicis (parched) 15g, RHIIZOMA DIOSCOREAE fr0m Henan of China 15g, Fructus Amomi 5g, Fructus Aurantii 15g, Radix Paeoniae Alba 15g, stir-baked RHIZOMA ANEMARRHENAE, each 5g of Cortex Phellodendri, Radix Achyranthis Bidentatae 15g, Fructus Corni 10g, Rhizoma Coptidis 10g, Radix Asparagi 15g).
Two groups 1 month is 1 course for the treatment of, all observes 2 months for two groups, carries out therapeutic evaluation after treatment terminates.
3, curative effect determinate standard:
(1) effective: after treatment, symptom disappears substantially, fasting glucose < 7.2mmol/L, 2h-plasma glucose < 8.3mmol/L, the quantitative < 10.0g of 24h glucose in urine; Or blood glucose, 24h glucose in urine quantitatively comparatively treatment before decline more than 30%;
(2) effective: after treatment, symptom is obviously improved, fasting glucose < 8.3mmol/L, 2h-plasma glucose < 10.0mmol/L, the quantitative < 25.0g of 24h glucose in urine; Or blood glucose, 24h glucose in urine quantitatively comparatively treatment before decline more than 10%;
(3) invalid: after treatment, symptom is not improved, blood glucose, glucose in urine decline and do not reach above-mentioned standard.
4, therapeutic effect:
In clinical observation process, treatment group comes off 5 routine cases, and matched group comes off 4 routine cases, and this 9 routine patient is all improvement backed off after randoms, and effectively to add up curative effect, all the other all complete clinical observation.Treatment group efficacy result is as follows: effective 40 examples (66.7%), effective 17 examples (28.3%), invalid 3 examples (5.0%), total effective rate 95.0%; Effective 21 examples (35.0%) of matched group, effective 29 examples (48.3%), invalid 10 examples (16.7%), total effective rate 83.3%.Between two groups, total effective rate compares, and treatment group is apparently higher than matched group.
In addition, give blood glucose, glucose in urine before and after two groups of treatments in table 2 to compare.Have clear improvement before all comparatively treating after the index treatments such as result display treatment group fasting glucose, 2h-plasma glucose, 24h glucose in urine are quantitative, all have highly significant gender gap (P < 0.01) through statistical test (t inspection); Matched group indices also has certain improvement, but fall is less, has significant difference (P < 0.05) compared with treatment group.In treatment group therapeutic process, vital sign steadily and without serious adverse reactions such as allergy, show that the clinical application of we is safely and effectively, is worth studying and applying further.
Before and after table 2 liang group treatment, blood glucose, glucose in urine compare
Claims (8)
1. treat a Chinese medicine composition for diabetes, it is characterized in that, it obtains primarily of the crude drug of following weight portion:
Radix Trichosanthis 7-9 part, Radix Scrophulariae 11-13 part, Rhizoma Atractylodis (parched) 17-19 part, Rhizoma Chuanxiong 14-16 part, Semen Coicis (parched) 6-8 part, Rhizoma dioscoreae (parched) 7-9 part, Fructus Schisandrae Chinensis 6-9 part, Fructus Corni 9-11 part, Poria 9-11 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, it is also containing, for example the crude drug of lower weight portion: Fructus Citri 5 parts and Fructus Amomi 7 parts.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that, it obtains primarily of the crude drug of following weight portion: Radix Trichosanthis 8 parts, Radix Scrophulariae 12 parts, Rhizoma Atractylodis (parched) 18 parts, Rhizoma Chuanxiong 15 parts, Semen Coicis (parched) 7 parts, Rhizoma dioscoreae (parched) 8 parts, Fructus Schisandrae Chinensis 8 parts, Fructus Corni 10 parts, Poria 10 parts, Fructus Citri 5 parts and Fructus Amomi 7 parts.
4. the Chinese medicine composition as described in claim 1-3, is characterized in that, it is powder, tablet, capsule or water preparation.
5. Chinese medicine composition as claimed in claim 4, its feature, it is capsule, containing white vaseline, glyceryl monostearate and stearic acid in described capsule.
6. prepare the method for Chinese medicine composition as claimed in claim 5 for one kind, it is characterized in that, it comprises the following steps: first, get Radix Trichosanthis, Radix Scrophulariae, Rhizoma Atractylodis (parched), Rhizoma Chuanxiong, Semen Coicis (parched), Rhizoma dioscoreae (parched), Fructus Schisandrae Chinensis, Fructus Corni, Poria, Fructus Citri and Fructus Amomi are broken into coarse powder, according to 6 times of soak by water 2 times of coarse powder gross weight, each 2 hours, merge decoction liquor, adding ethanol to concentration is 60%, place 24 hours, filter, alcohol deposit fluid decompression recycling ethanol, be concentrated into extractum, extract dry becomes fine powder, add appropriate white vaseline again, glyceryl monostearate and stearic acid mixing, capsule is made with conventional fabrication process.
7. the purposes of the Chinese medicine composition as described in claim 1-3 in the medicine of preparation treatment diabetes.
8. the purposes of the Chinese medicine composition as described in claim 1-3 in the medicine of preparation treatment intense heat due to deficiency of YIN patients with type Ⅰ DM.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105011278A (en) * | 2015-07-05 | 2015-11-04 | 青岛浩大海洋保健食品有限公司 | Blood sugar lowering chitosan health-care beverage |
| CN109364211A (en) * | 2018-12-28 | 2019-02-22 | 上海优童医药科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating fever |
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| CN1931334A (en) * | 2006-09-26 | 2007-03-21 | 李卓伦 | Diabetes treating medicine |
| CN103405658A (en) * | 2013-08-28 | 2013-11-27 | 安耀苍 | Drug for treating diabetes mellitus and preparation method thereof |
| CN103989899A (en) * | 2014-04-21 | 2014-08-20 | 李本楠 | Traditional Chinese medicine for treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931334A (en) * | 2006-09-26 | 2007-03-21 | 李卓伦 | Diabetes treating medicine |
| CN103405658A (en) * | 2013-08-28 | 2013-11-27 | 安耀苍 | Drug for treating diabetes mellitus and preparation method thereof |
| CN103989899A (en) * | 2014-04-21 | 2014-08-20 | 李本楠 | Traditional Chinese medicine for treating diabetes |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105011278A (en) * | 2015-07-05 | 2015-11-04 | 青岛浩大海洋保健食品有限公司 | Blood sugar lowering chitosan health-care beverage |
| CN109364211A (en) * | 2018-12-28 | 2019-02-22 | 上海优童医药科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating fever |
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