CN106902250A - A kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes - Google Patents
A kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes Download PDFInfo
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Abstract
The invention discloses a kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, it is made up of the raw material of following weight percentage：Metformin hydrochloride（Sustained release parcel）1.7%th, hydrochloric acid Glimepiride 0.003%, Pioglitazone 0.05%, pseudo-ginseng 19%, raw oyster 15%, Os Draconis 19%, gypsum 15%, Chinese medical concrete 30.247%, described Chinese medical concrete are made up of the raw material that following weight is matched：6 parts of the Radix Astragali, 7 parts of Radix Codonopsis, 5 parts of kuh-seng, 8 parts of the red sage root, 6 parts of radix achyranthis bidentatae, 9 parts of the dried rhizome of rehmannia, 8 parts of cultivated land, 5 parts of Chinese yam, 9 parts of chrysanthemum, 8 parts of the fruit of glossy privet, 7 parts of the fruit of summer cypress, 6 parts of dittany bark, 7 parts of rhizoma cyperi, 8 parts of Ligusticum wallichii, 9 parts of rhizoma cibotii, 8 parts of the tuber of dwarf lilyturf, 6 parts of adenophora tetraphylla, 5 parts of root of Chinese trichosanthes, 7 parts of radix polygonati officinalis.The medicine preparation is simple, can quickly reduce and stablize the blood glucose value of diabetic, treats diabetes and its complication effect is significant.
Description
Technical field
The present invention relates to pharmaceutical field, and in particular to a kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes.
Background technology
Diabetes (Diabetes Mellitus) are that the metabolism being characterized with chronic hyperglycemia caused by Different types of etiopathogenises is disorderly
Disorderly disease, is fatal rate, the third-largest disease of disability rate highest after cardiovascular and cerebrovascular disease, cancer.In recent years, as people give birth to
The reasons such as the flat raising of running water, overnutrition, motion reduction, onset diabetes rate increases severely year by year, it has also become a kind of serious
The disease of human health is influenceed, also brings tremendous economic to bear to society.At present, the medicine for the treatment of diabetes mainly has oral drop
Sugared medicine and insulin.In general, Western medicine determined curative effect, clear mechanism, but there are various side effects, cannot effect a radical cure etc. and lack
Point.Although and Chinese medicine have the advantages that to treat both principal and secondary aspect of disease, safety, few side effects, effective in cure imprecise, slowly effect etc. is not no
Foot.
Domestic and international prior art products：
Diabecron sustained-release tablet
Purpose：Reduce blood sugar.
Technical measures：The enteron aisle inwall of hyperglycemic patients is covered in, delays and block absorption of the enteron aisle to glucose, so that
Reach the purpose for reducing blood sugar.
Effect assessment：To mild diabetes, patient individually takes, you can completely by glycemic control in normal range (NR).But for
Intractable moderate, severe hyperglycemia population, individually take, it is impossible to blood sugar is down into normal level, less effective completely, it is necessary to join
Other hypoglycemic medicines are closed while taking.
Hydrochloric acid glimepiride tablet
Purpose：Reduce blood sugar.
Technical measures：This product belongs to sulfonylureas drugs for diabetes, by stimulating patient's pancreas, increases the secretory volume of insulin, so that
Reach the purpose of hypoglycemic.
Effect：For the mild diabetes patient of the hyposecretion of insulin, more it is applicable.For and have no lack of pancreas islet
Element, is only numerous patients of susceptibility reduction, is not applied to.For in, severe diabetic individually take, effect is undesirable.
Need to combine and take other kinds of hypoglycemic medicine.
Rates of Pioglitazone Hydrochloride Tablets Preparation
Purpose：Reduce blood sugar.
Technical measures：This product belongs to insulin sensitizer, itself not direct hypoglycemic, and this product is by improving patient to it
The susceptibility of secreted insulin itself reduces blood glucose value, and side effect is less.
Effect：This product individually is taken, hypoglycemic effect is weaker.Diabetic for all slight, moderate, severes fits
With being particularly suited for obese diabetic patient.
Chinese medicine Tangniaole capsule
Purpose：The various complication of diabetes are treated, blood sugar is steadily adjusted.
Technical measures：Pure Chinese medicinal preparation, by the way that for promoting blood circulation and removing blood stasis, combining for the medicine of supplementing qi and nourishing yin is enabled, and is reached flat
Steady hypoglycemic, eliminates the purpose of various complication.
Effect：Short-term hypoglycemic effect is slower, and long-term steady sugar effect is good, treats both principal and secondary aspect of disease.
Diabetes pill
Purpose：Regulation blood sugar, treats diabetic complication.
Technical measures：By the effect of glibenclamide, in a short time, fast gliquidone is made by the joint of ten plurality of Chinese
With, collaboration hypoglycemic is reached, stabilizing blood sugar eliminates the effect of complication.
The B of Chinese patent CN 103705711 are disclosed and a kind of are treated Chinese medicine compound prescription of diabetes and preparation method thereof.Carried
A kind of Chinese medicine composition for treating diabetes for supplying, by wolf's milk, the red sage root, the raw Radix Astragali, the wind-weed and the coptis constitute, by animal reality
Test and understand there is certain blood sugar decreasing effect.But be not directed to Severe Diabetes Mellitus patient blood glucose value remain high, and prevention and
Treat the complication triggered by diabetes.
Present invention seek to address that the high problem of intractable, severe blood sugar in diabetic patients, makes the blood glucose value of patient
After being reduced to normal level, stable for extended periods of time, while the effectively complication for the treatment of diabetes.
The content of the invention
In view of the deficiency of existing treatment diabetes medicament, can effectively reduce and stabilization it is an object of the invention to provide one kind
Blood glucose value, and can effectively treat the compound medicine of the traditional Chinese and western medicine therapeutic alliance diabetes of diabetic complication.Concrete technical scheme
It is as follows：
A kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, is made up of the raw material of following weight percentage：Hydrochloric acid
Melbine (sustained release parcel) 1.7%~5%, hydrochloric acid Glimepiride 0.003%~0.04%, Pioglitazone 0.05%~
0.3%th, pseudo-ginseng 16%~23%, raw oyster 12%~18%, Os Draconis 17%~25%, gypsum 10%~20%, Chinese medicine
Medicinal extract 27%~31%, described Chinese medical concrete is made up of the raw material that following weight is matched：6~10 parts of the Radix Astragali, Radix Codonopsis 7~12
Part, 5~8 parts of kuh-seng, 8~11 parts of the red sage root, 6~14 parts of radix achyranthis bidentatae, 9~11 parts of the dried rhizome of rehmannia, 8~13 parts of cultivated land, 5~15 parts of Chinese yam,
9~17 parts of chrysanthemum, 8~13 parts of the fruit of glossy privet, 7~15 parts of the fruit of summer cypress, 6~11 parts of dittany bark, 7~12 parts of rhizoma cyperi, Ligusticum wallichii 8~16
Part, 9~14 parts of rhizoma cibotii, 8~10 parts of the tuber of dwarf lilyturf, 6~10 parts of adenophora tetraphylla, 5~12 parts of root of Chinese trichosanthes, 7~9 parts of radix polygonati officinalis.
A kind of preparation method of the compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, comprises the following steps that：
(1) preparation method of Chinese medical concrete：Take 6~10 parts of the Radix Astragali, 7~12 parts of Radix Codonopsis, 5~8 parts of kuh-seng, the red sage root 8~11
Part, 6~14 parts of radix achyranthis bidentatae, 9~11 parts of the dried rhizome of rehmannia, 8~13 parts of cultivated land, 5~15 parts of Chinese yam, 9~17 parts of chrysanthemum, the fruit of glossy privet 8~13
Part, 7~15 parts of the fruit of summer cypress, 6~11 parts of dittany bark, 7~12 parts of rhizoma cyperi, 8~16 parts of Ligusticum wallichii, 9~14 parts of rhizoma cibotii, the tuber of dwarf lilyturf 8~10
Part, 6~10 parts of adenophora tetraphylla, 5~12 parts of root of Chinese trichosanthes, 7~9 parts of radix polygonati officinalis, to start to decoct after 6 times of volume distilled water immersion 2h, plus
Heat continues small fire and decocts 1h to seething with excitement after boiling, filtering is collected liquid, decocted altogether twice.The liquid for merging twice is depressurized
After low temperature concentration, in paste, drying is ground into fine powder, and 100~150 mesh sieves excessively are standby, and withdrawal ratio is 5:1；
(2) take pseudo-ginseng, raw oyster, Os Draconis, gypsum respectively, clean impurity elimination, fine powder is ground into after drying, cross 100~
It is standby after 200 mesh sieves；
(3) by containing Metformin hydrochloride (sustained release parcel) 1.7%~5%, hydrochloric acid Glimepiride in every 100 grams of medicines
0.003%~0.04%, Pioglitazone 0.05%~0.3%, pseudo-ginseng 16%~23%, raw oyster 12%~18%, Os Draconis
17%~25%, gypsum 10%~20%, the proportioning of Chinese medical concrete 27%~31% weigh each component, and are sufficiently stirred for
Uniformly；
(4) ball, packing, 10 grams every bag are made by well mixed medicinal powder is general.
Present invention selection Metformin hydrochloride (sustained release parcel), hydrochloric acid Glimepiride, Pioglitazone, its principle and act as
Melbine (sustained release) acts on the alimentary canal of patient, absorption and utilization of the intestines and stomach to glucose is reduced, so as to reduce blood sugar；
Hydrochloric acid Glimepiride increases the secretory volume of insulin by stimulating patient's pancreas excreting insulin, so as to reach reduction blood sugar
Purpose；PIOGITAZONE HYDROCHLORIDE can improve susceptibility and utilization rate of the diabetic to insulin, so as to reduce blood sugar.Institute
It is monarch drug in a prescription to be replenished qi to invigorate the spleen with the Radix Astragali, Radix Codonopsis, Chinese yam in traditional Chinese medicinal components；Adenophora tetraphylla, the tuber of dwarf lilyturf, root of Chinese trichosanthes, radix polygonati officinalis, dried rhizome of rehmannia enriching yin are clear
Heat, the fruit of glossy privet, cultivated land are enriched blood yin-nourishing, are ministerial drug；Ligusticum wallichii, the root of bidentate achyranthes, the red sage root, pseudo-ginseng, rhizoma cibotii are promoting blood circulation and removing blood stasis, kuh-seng, Huai Chrysanthemi, life
Gypsum is dispelled, and fire drop is dry, and Os Draconis, raw oyster tranquilizing and allaying excitement, are adjutant；Rhizoma cyperi is refreshed oneself and has one's ideas straightened out, the antipruritic hypoglycemic of the fruit of summer cypress, dittany bark
To make medicine, by supplementing qi and nourishing yin, it is promoting blood circulation and removing blood stasis, promote blood circulation promote the production of body fluid, qi-regulating of calming the nerves reaches reduction blood sugar, treatment diabetes and its concurrent
Effect of disease.
The formula that the present invention is provided is the science obtained by a large amount of practices and research under traditional Chinese and western medicine theory guiding by association
Proportioning, the medicine each component consumption of present invention treatment diabetes rationally breaches medicine in the market, only from an angle
Or one side carrys out the limitation of hypoglycemic, from multi-angle, many-sided effect simultaneously, comprehensive measure, effect is more preferable.
The formulation of the compound medicine finished product of the traditional Chinese and western medicine therapeutic alliance diabetes that the present invention is provided is the concentration water-bindered pill, daily one
It is secondary, 1~3 bag every time.
Each raw material pharmacology is as follows in Chinese medicine preparation of the present invention：
Pseudo-ginseng：It is warm in nature, sweet, slight bitter.Return liver, stomach.Dissipate stasis of blood hemostasis, detumescence ding-tong.For spitting blood, spit blood, bleeding from five sense organs or subcutaneous tissue, just
Blood, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, tumbling and swelling.
Raw oyster：Cold nature, taste is salty.Return liver, courage, kidney channel.Calming the liver, transquilization with heavy material, softening and resolving hard mass is restrained astringent or styptic treatment for spontaneous sweating.
With enriching yin, blood-nourishing, tonifying five zang organs, invigorate blood circulation, fill flesh the effects such as.
Os Draconis：It is mild-natured, sweet-puckery flavor.The thoughts of returning home, liver and kidney channel.Health product checking exuberant yang to ease mental strain, for hyperactivity of yang due to yin deficiency, irritable, the heart
Throb with fear insomnia, have a dizzy spell, it is demented frightened to wait disease；Forge rear work(and restrain partially astringent or styptic treatment for spontaneous sweating, be used for premature ejaculation of passing out semen, under band uterine bleeding, abnormal sweating chronic diarrhea,
Wet sore pruigo, the open sore part is not held back, traumatism and bleeding etc..Additionally, forge grinding external application, energy hygroscopic sore controls wet sore flowing water again, does not with the passing of time heal
Person.
Gypsum：It is sweet, pungent, Great Cold.Attach to the lung and stomach meridians.Expelling pathogenic factors from muscles for clearing heat；Relieving restlessness is quenched the thirst.Main pyreticosis high fever is not moved back；Vexed god
Dusk；Delirious speech is gone mad；Thirsty and dry pharynx；Lung heat breathes heavily urgency；Heatstroke spontaneous perspiration；Stomach headache due to fire-evil；Gastropyretic toothache；Heat toxin stops up Sheng；Spot dermexanthesis；Mouthful
Tongue gives birth to sore；Ulcer sores；Burst and do not close up；The burning hot wound of soup.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, the high Sheng of stomach fire, head
Bitterly, have a toothache.
The Radix Astragali：It is warm in nature, it is sweet.Return lung, the spleen channel.Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.For treatment deficiency of vital energy weak, long
Rush down the long disunion of prolapse of the anus, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the open sore part.
Radix Codonopsis：It is mild-natured, it is sweet.Tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.For spleen eating less loose stool, weakness of limbs,
Palpitaition, shortness of breath, dry, spontaneous perspiration, prolapse of the anus, the prolapse of uterus.
The red sage root：Cold nature, bitter.Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity
Abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
Radix achyranthis bidentatae：It is mild-natured, bitter acid.Promoting blood circulation to remove blood stasis, clearing damp diuresis is clearing heat and detoxicating.Control gonorrhoea, hematuria, women's Amenorrhea, disease
Lump in the abdomen, rheumatic arthritis, tinea pedis, oedema, dysentery, malaria, diphtheria, carbuncle swells, traumatic injury.
The dried rhizome of rehmannia：It is cold in nature, sweet, hardship.The thoughts of returning home, liver, kidney three are passed through.Enriching yin, cool blood.For fever due to yin deficiency, consumption of YIN caused by febrile disease is tired of
The diseases such as yearningly, hectic fever due to yin, macula, blood under hematemesis, menoxenia, fetal irritability.
Cultivated land：It is warm in nature, it is sweet.Return liver and kidney channel.Enrich blood moist, beneficial to spirit and marrow.Main blood tiger is sallow；Dizziness palpitaition；Menstruation is not
Adjust；Collapse more than；Liver-kidney Yin deficiency；Hectic fever night sweat；Seminal emission impotence；Infertility；Soreness and weakness of waist and knees；Hiccough and deaf；Head is dim-sighted；Beard and hair
It is early white；Quench one's thirst；Constipation；Syndrome characterized by dyspnea.For the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, the deficiency of blood
It is sallow, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, poliosis.
Chinese yam：It is mild-natured, it is sweet.Returns spleen warp, lung channel, kidney channel.With engender liquid and benefic lung, tonifying spleen nourishing the stomach, the function of the puckery essence of kidney tonifying.
For splenasthenic diarrhea, protracted dysentery, the deficiency syndrome of the lung is breathed with cough, and emission due to the kidney deficiency, under band, frequent micturition, abnormal heat is quenched one's thirst.
Chrysanthemum：Cold nature, pungent, sweet, hardship.Return lung, Liver Channel.Dispelling wind and heat from the body, flat liver improving eyesight is clearing heat and detoxicating.
The fruit of glossy privet：Sweet, hardship, it is cool in nature.Return liver and kidney channel.Filling liver kidney, strong waist and knee.Yin asthenia generating intrinsic heat is controlled, dizzy, mesh flower, ear
Ring, soreness and weakness of waist and knees, poliosis.It is nourishing liver and kidney, improving eyesight black hair.For dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, mesh are secretly not
It is bright.
The fruit of summer cypress：Sweetness and bitterness, trembles with fear.Enter kidney, bladder warp.Diuresis, clearing away damp-heat.Control difficult urination, gonorrhoea, under band, hernia, wind
Rash, sore, mange, private parts is wet to itch.
Dittany bark：It is bitter；It is salty；It is cold.Enter spleen, stomach.Heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances.Wind caused by main wind-heat wet poison
Rash；Eczema；Mange；Jaundice；Damp-heat arthralgia.For damp and hot sore, yellow water is dripping, eczema, rubella, mange sore leprosy, beriberoid pyretic arthralgia, yellow
Subcutaneous ulcer urine is red.
Rhizoma cyperi：Taste is pungent；It is slightly cold；It is nontoxic.Enter liver, tri-jiao channel.Regulating the flow of vital energy Xie Yu；Menstruction regulating and pain relieving；It is antiabortive.The main distending pain in hypochondrium；Breast
Room educated；Hernia pain；Irregular menstruation；Gastral cavity abdomen ruffian is full pain；Belch acid regurgitation, evil of vomitting；Dysmenorrhea；Uterine bleeding under band；Movement of the foetus is not
Peace.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, indigestion, chest gastral cavity ruffian, cold hernia stomachache, swollen breasts, irregular menstruation,
Closed dysmenorrhea.
Ligusticum wallichii：Taste is pungent；It is warm in nature.Enter liver, gallbladder channel.Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache rotation dizzy, the side of body
Pain abdomen ache, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block bitterly, ulcer sores.For irregular menstruation, closed dysmenorrhea, lump in the abdomen is suffered from abdominal pain,
Chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Rhizoma cibotii：It is bitter, sweet, it is warm in nature.Return liver and kidney channel.Wind-damp dispelling, filling liver kidney, strong waist and knee.For arthralgia pain due to rheumatism, waist and knee acid
It is soft, weakness of the lower extremities.
The tuber of dwarf lilyturf：Nature and flavor are sweet, slight bitter, are slightly cold.The thoughts of returning home, lung, stomach.Nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire.For dryness of the lung dry cough.It is empty
Consumptive disease is coughed, injury thirst, vexed insomnia, Heat Diabetes, dry constipation of intestines；Pharyngeal diphtheria.
Adenophora tetraphylla：It is sweet, cold nature.Attach to the lung and stomach meridians.Nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid, resolving sputum, QI invigorating.It is dry for lung heat
Cough, deficiency of Yin labor is coughed, dry cough phlegm is sticked, deficiency of stomach-Yin, deficiency of food vomiting, deficiency of both vital energy and Yin, restlessness and fever with thirst.
Root of Chinese trichosanthes：Sweet, slight bitter, is slightly cold.Attach to the lung and stomach meridians.Clearing heat-fire, promotes the production of body fluid to quench thirst, detumescence and apocenosis.Pyreticosis polydipsia, lung
Hot cough caused by dryness, Heat Diabetes, sore swollen toxin.
Radix polygonati officinalis：Nature and flavor are sweet, are slightly cold.Attach to the lung and stomach meridians.Nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst.For lung stomach impairment of yin, cough caused by dryness-heat, pharynx
Do thirsty, Heat Diabetes.
The compound medicine of the traditional Chinese and western medicine therapeutic alliance diabetes that the present invention is provided, compared with prior art with following beneficial
Effect：
1st, the medicine that the present invention is provided solves Chinese medicine hypoglycemic slowly, and the shortcoming that Western medicine hypoglycemic easily fluctuates, easily rebounds can be fast
The blood glucose value of the low diabetic of prompt drop, and blood glucose value is stably held in normal range (NR), for only taking one or two kind of medicine
Or only by dietotherapy be difficult to effectively control blood glucose value moderate, severe diabetic, it is especially suitable；
2nd, the medicine that the present invention is provided is treated both principal and secondary aspect of disease, and taking this medicine can mitigate diabetes, and blood sugar gradually recovers normal
Value, is not in the resistance to the action of a drug of Western medicine, and dosage can be gradually reduced to withdraws；
3rd, the medicine that the present invention is provided can also prevent and effectively treat diabetic complication, such as：Diabetic oculopathy (eye
Bottom retinal hemorrhage, optic atrophy etc.) the various complication such as diabetic keratopathy foot disease (bad numbness) diabetic cardiomyopathy, ephrosis,
It is evident in efficacy.
Brief description of the drawings
Fig. 1 is OGTT testing results before administration, in figure：1 is blank control group, and 2 is model control group, and 3 is hydrochloride
Biguanides group, 4 is that experimental group 1,5 is that experimental group 2,6 is experimental group 3.
Fig. 2 is OGTT testing results after administration, in figure：1 is blank control group, and 2 is model control group, and 3 is hydrochloride
Biguanides group, 4 is that experimental group 1,5 is that experimental group 2,6 is experimental group 3.
Specific embodiment
Further to illustrate technological means and its effect that the present invention is taken, it is preferable to carry out below in conjunction with of the invention
Example is described in detail.
Embodiment 1
A kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, is made up of the raw material of following weight percentage：Hydrochloric acid
Melbine (sustained release parcel) 1.7%, hydrochloric acid Glimepiride 0.003%, Pioglitazone 0.05%, pseudo-ginseng 19%, raw oyster
15%th, Os Draconis 19%, gypsum 15%, Chinese medical concrete 30.247%, the original that described Chinese medical concrete is matched by following weight
Material is made：6 parts of the Radix Astragali, 7 parts of Radix Codonopsis, 5 parts of kuh-seng, 8 parts of the red sage root, 6 parts of radix achyranthis bidentatae, 9 parts of the dried rhizome of rehmannia, 8 parts of cultivated land, 5 parts of Chinese yam, chrysanthemum
9 parts, 8 parts of the fruit of glossy privet, 7 parts of the fruit of summer cypress, 6 parts of dittany bark, 7 parts of rhizoma cyperi, 8 parts of Ligusticum wallichii, 9 parts of rhizoma cibotii, 8 parts of the tuber of dwarf lilyturf, 6 parts of adenophora tetraphylla,
5 parts of root of Chinese trichosanthes, 7 parts of radix polygonati officinalis.
A kind of preparation method of the compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, comprises the following steps that：
(1) preparation method of Chinese medical concrete：Take 6 parts of the Radix Astragali, 7 parts of Radix Codonopsis, 5 parts of kuh-seng, 8 parts of the red sage root, 6 parts of radix achyranthis bidentatae, life
Ground 9 parts, 8 parts of cultivated land, 5 parts of Chinese yam, 9 parts of chrysanthemum, 8 parts of the fruit of glossy privet, 7 parts of the fruit of summer cypress, 6 parts of dittany bark, 7 parts of rhizoma cyperi, 8 parts of Ligusticum wallichii,
9 parts of rhizoma cibotii, 8 parts of the tuber of dwarf lilyturf, 6 parts of adenophora tetraphylla, 5 parts of root of Chinese trichosanthes, 7 parts of radix polygonati officinalis, to start to decoct after 6 times of volume distilled water immersion 2h,
Boiling is heated to, small fire is continued after boiling and is decocted 1h, filtering is collected liquid, decocted altogether twice.The liquid for merging twice is subtracted
After forcing down temperature concentration, in paste, drying is ground into fine powder, and 120 mesh sieves excessively are standby, and withdrawal ratio is 5:1；
(2) pseudo-ginseng, raw oyster, Os Draconis, gypsum are taken respectively, impurity elimination is cleaned, fine powder is ground into after drying, cross 130 mesh
It is standby after sieve；
(3) by containing Metformin hydrochloride (sustained release parcel) 1.7%, hydrochloric acid Glimepiride in every 100 grams of medicines
0.003%th, Pioglitazone 0.05%, pseudo-ginseng 19%, raw oyster 15%, Os Draconis 19%, gypsum 15%, Chinese medical concrete
30.247% proportioning weighs each component, and is stirred；
(4) ball, packing, 10 grams every bag are made by well mixed medicinal powder is general.
Embodiment 2
A kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, is made up of the raw material of following weight percentage：Hydrochloric acid
Melbine (sustained release parcel) 5%, hydrochloric acid Glimepiride 0.04%, Pioglitazone 0.3%, pseudo-ginseng 18%, raw oyster 19%, life
Keel 18%, gypsum 11%, Chinese medical concrete 28.66%, described Chinese medical concrete are made up of the raw material that following weight is matched：It is yellow
10 parts of stilbene, 12 parts of Radix Codonopsis, 8 parts of kuh-seng, 11 parts of the red sage root, 14 parts of radix achyranthis bidentatae, 11 parts of the dried rhizome of rehmannia, 13 parts of cultivated land, 15 parts of Chinese yam, chrysanthemum 17
Part, 13 parts of the fruit of glossy privet, 15 parts of the fruit of summer cypress, 11 parts of dittany bark, 12 parts of rhizoma cyperi, 16 parts of Ligusticum wallichii, 14 parts of rhizoma cibotii, 10 parts of the tuber of dwarf lilyturf, Nansha
10 parts of ginseng, 12 parts of root of Chinese trichosanthes, 9 parts of radix polygonati officinalis.
A kind of preparation method of the compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, comprises the following steps that：
(1) preparation method of Chinese medical concrete：Take 10 parts of the Radix Astragali, 12 parts of Radix Codonopsis, 8 parts of kuh-seng, 11 parts of the red sage root, radix achyranthis bidentatae 14
Part, 11 parts of the dried rhizome of rehmannia, 13 parts of cultivated land, 15 parts of Chinese yam, 17 parts of chrysanthemum, 13 parts of the fruit of glossy privet, 15 parts of the fruit of summer cypress, 11 parts of dittany bark, rhizoma cyperi
12 parts, 16 parts of Ligusticum wallichii, 14 parts of rhizoma cibotii, 10 parts of the tuber of dwarf lilyturf, 10 parts of adenophora tetraphylla, 12 parts of root of Chinese trichosanthes, 9 parts of radix polygonati officinalis, with 6 times of volume distilled water
Start to decoct after immersion 2h, be heated to boiling, small fire is continued after boiling and decocts 1h, filtering is collected liquid, decocted altogether twice.Close
And after liquid twice carries out decompression low temperature concentration, in paste, drying is ground into fine powder, it is standby to cross 120 mesh sieves, extracts ratio
Example is 5:1；
(2) pseudo-ginseng, raw oyster, Os Draconis, gypsum are taken respectively, impurity elimination is cleaned, fine powder is ground into after drying, cross 130 mesh
It is standby after sieve；
(3) by containing Metformin hydrochloride (sustained release parcel) 5%, hydrochloric acid Glimepiride 0.04%, pyrrole in every 100 grams of medicines
Lattice row ketone 0.3%, pseudo-ginseng 18%, raw oyster 19%, Os Draconis 18%, gypsum 11%, the proportioning of Chinese medical concrete 28.66% claim
Each component is taken, and is stirred；
(4) ball, packing, 10 grams every bag are made by well mixed medicinal powder is general.
Embodiment 3
A kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, is made up of the raw material of following weight percentage：Hydrochloric acid
Melbine (sustained release parcel) 2%, hydrochloric acid Glimepiride 0.01%, Pioglitazone 0.15%, pseudo-ginseng 18%, raw oyster 15%,
Os Draconis 20%, gypsum 15%, Chinese medical concrete 29.84%, described Chinese medical concrete are made up of the raw material that following weight is matched：
8 parts of the Radix Astragali, 10 parts of Radix Codonopsis, 7 parts of kuh-seng, 9 parts of the red sage root, 10 parts of radix achyranthis bidentatae, 10 parts of the dried rhizome of rehmannia, 11 parts of cultivated land, 10 parts of Chinese yam, chrysanthemum 12
Part, 11 parts of the fruit of glossy privet, 12 parts of the fruit of summer cypress, 8 parts of dittany bark, 9 parts of rhizoma cyperi, 14 parts of Ligusticum wallichii, 12 parts of rhizoma cibotii, 9 parts of the tuber of dwarf lilyturf, adenophora tetraphylla 8
Part, 9 parts of root of Chinese trichosanthes, 8 parts of radix polygonati officinalis.
A kind of preparation method of the compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, comprises the following steps that:
(1) preparation method of Chinese medical concrete：Take 8 parts of the Radix Astragali, 10 parts of Radix Codonopsis, 7 parts of kuh-seng, 9 parts of the red sage root, 10 parts of radix achyranthis bidentatae,
10 parts of the dried rhizome of rehmannia, 11 parts of cultivated land, 10 parts of Chinese yam, 12 parts of chrysanthemum, 11 parts of the fruit of glossy privet, 12 parts of the fruit of summer cypress, 8 parts of dittany bark, 9 parts of rhizoma cyperi,
14 parts of Ligusticum wallichii, 12 parts of rhizoma cibotii, 9 parts of the tuber of dwarf lilyturf, 8 parts of adenophora tetraphylla, 9 parts of root of Chinese trichosanthes, 8 parts of radix polygonati officinalis, after 6 times of volume distilled water immersion 2h
Start to decoct, be heated to boiling, small fire is continued after boiling and decocts 1h, filtering is collected liquid, decocted altogether twice.Merge twice
After liquid carries out decompression low temperature concentration, in paste, drying is ground into fine powder, and 100~150 mesh sieves excessively are standby, and withdrawal ratio is
5:1；
(2) take pseudo-ginseng, raw oyster, Os Draconis, gypsum respectively, clean impurity elimination, fine powder is ground into after drying, cross 100~
It is standby after 200 mesh sieves；
(3) by containing Metformin hydrochloride (sustained release parcel) 2%, hydrochloric acid Glimepiride 0.01%, pyrrole in every 100 grams of medicines
Lattice row ketone 0.15%, pseudo-ginseng 18%, raw oyster 15%, Os Draconis 20%, gypsum 15%, the proportioning of Chinese medical concrete 29.84%
Each component is weighed, and is stirred；
(4) ball, packing, 10 grams every bag are made by well mixed medicinal powder is general.
The hypoglycemic effect of compound medicine：
First, animal packet
It is divided into following 6 groups：
Blank control group：Healthy male C 57 BL/6 J mouse, 25-30g, 9 week old, totally 8.
Diabetes group：Healthy male kk/Upj-Ay mouse, 30-40g, 9 week old, totally 60.By healthy male kk/Upj-
Ay mouse adaptability is raised 1 week, surveys random blood sugar>11.1mmol·L-1Or fasting blood-glucose>7.0mmol·L-1It is considered as diabetes
Model, selects 45, and be randomly divided into model control group, Metformin hydrochloride group (200mg/kg), experimental group 1, reality altogether
Test group 2, experimental group 3, every group 9.
2nd, the dosage of each group mouse
Give distilled water during blank control group mouse stomach, according to 0.1mL10g-1Gavage is carried out, daily gavage 1 time connects
Continuous gavage 2 weeks.
Give distilled water during model control group gavage, according to 0.1mL10g-1Gavage is carried out, daily gavage 1 time is continuous to fill
Stomach 2 weeks.
The administration of Metformin hydrochloride group is Metformin hydrochloride, gavage is carried out according to 200mg/kg, by hydrochloric acid two during gavage
First biguanides is dissolved with distilled water, is configured to 20mg/mL concentration, daily gavage 1 time, continuous gavage 2 weeks.
The administration of experimental group 1 is Metformin hydrochloride (the sustained release parcel) 1.7%, hydrochloric acid Glimepiride of embodiment 1
0.003%th, the Western medicine compound of Pioglitazone 0.05%, gavage is carried out according to 8g/kg, and the Western medicine compound is steamed with double during gavage
Water is dissolved, and is configured to 0.8g/mL concentration, daily gavage 1 time, continuous gavage 2 weeks.
Experimental group 2 is pseudo-ginseng 19%, raw oyster 15%, Os Draconis 19%, the gypsum 15%, Chinese medicine that embodiment 1 is prepared
The Traditional Chinese drug mixture of medicinal extract 30.247%, gavage is carried out according to 8g/kg, is carried out the Traditional Chinese drug mixture with distilled water during gavage molten
Solution, is configured to 0.8g/mL concentration, daily gavage 1 time, continuous gavage 2 weeks.
Experimental group 3 is Metformin hydrochloride (the sustained release parcel) 1.7%, hydrochloric acid Glimepiride that embodiment 1 is prepared
0.003%th, Pioglitazone 0.05%, pseudo-ginseng 19%, raw oyster 15%, Os Draconis 19%, gypsum 15%, Chinese medical concrete
The compound medicine of 30.247% traditional Chinese and western medicine therapeutic alliance diabetes, gavage is carried out according to 8g/kg, by the compound medicine during gavage
Dissolved with distilled water, be configured to 0.8g/mL concentration, daily gavage 1 time, continuous gavage 2 weeks.
3rd, be administered before and administration after blood sugar detection
(1) detection of index before being administered
1st, the body weight of each group mouse is weighed.
2nd, water 4h is can't help into each group mouse fasting, takes tail point venous blood and fasting blood-glucose is detected using glucose oxidase method.
3rd, oral glucose tolerance (OGTT) detection.
After fasting blood-glucose has been surveyed, each group mouse stomach glucose solution is given immediately by the dosage of 2g/kg, and in administration
Afterwards 30,60,120min collects Mouse Tail-tip venous blood, and each time point blood sugar is detected using glucose oxidase method, sees Fig. 1, and
Blood sugar concentration TG-AUC (AUCg) is calculated, as a result as shown in table 1.
Table 1 is administered preceding each group Mouse Weight, fasting blood-glucose and OGTT TG-AUCs
| Group | Body weight (g) | AUCg(OGTT) | |
| Blank control group | 23.36±2.57 | 5.51±2.05 | 8.59±3.15 |
| Model control group | 26.32±1.85 | 10.26±2.05 | 17.47±3.01 |
| Metformin hydrochloride group | 31.45±2.48 | 10.17±2.87 | 16.66±5.34 |
| Experimental group 1 | 34.48±3.18 | 10.14±3.46 | 18.62±4.94 |
| Experimental group 2 | 35.87±3.76 | 10.32±3.08 | 17.77±4.66 |
| Experimental group 3 | 33.74±1.94 | 10.56±3.15 | 16.87±4.87 |
(2) detection of index after being administered
1st, the body weight of each group mouse is weighed after last time gavage.
2nd, each group mouse is after last time gavage, and water 4h is can't help in fasting, surveys fasting blood-glucose, surveys 2h gavages before fasting blood-glucose
Administration.
3rd, oral glucose tolerance (OGTT) detection.
After fasting blood-glucose has been surveyed, each group mouse stomach glucose solution is given immediately by the dosage of 2g/kg, and in administration
Afterwards 30,60,120min collects Mouse Tail-tip venous blood, and each time point blood sugar is detected using glucose oxidase method, sees Fig. 2, and
Blood sugar concentration TG-AUC (AUCg) is calculated, as a result as shown in table 2.
Each group Mouse Weight, fasting blood-glucose and OGTT TG-AUCs after the administration of table 2
Metformin hydrochloride, the western medicine composition of this compound medicine, traditional Chinese medicine ingredients and compound medicine as can be seen from Table 2
The overall influence to each group Mouse Weight, fasting blood-glucose and OGTT TG-AUCs.After two weeks, Western medicine of the invention into
Divide, traditional Chinese medicine ingredients and compound medicine are integrally respectively provided with the effect for reducing diabetic mice fasting blood-glucose and reducing OGTT TG-AUCs
Really, the overall effect of compound medicine is more notable.
Below in conjunction with treatment case clinically to the usage of the compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes of the present invention
Consumption, indication, and effect is explained in detail：
From 2009 to 2016, using this kind of drug treatment of diabetic 523, women 257, male 266, averagely
Age 43-74 Sui, the course of disease most short half a year is most long 30 years.Wherein upper elimination type 125, blood sugar level is tested after treating three months, is had
More apparent descender 100,1 blood sugar level slightly declines, and 1 invalid.In disappear 216, type, blood sugar is put down after treatment five months
Equal level reaches normal level 189, declines but still more slightly biased person high 17, total effective rate 95.4%, 6 sugar in remaining 10
The sick complication symptom of urine has been alleviated.Under disappear 182, type, test result show effective 127 after treatment half a year, before treatment averagely
Fasting blood-glucose 14.6mmol/L, postprandial blood sugar 19.2mmol/L, average fasting blood-glucose 7.3mmol/L, postprandial blood sugar after treatment
11.02mmol/L, declines 50% and 42.6% respectively.In above-mentioned all types of case therapeutic processes, complication rate significantly subtracts
It is low.
Model case
1st, Li Yunlin, man, 62 years old, suffers from diabetes 12 years, and type II diabetes takes glibenclamide before this, 3 times/day, 2/
It is secondary, DB2,3 times/day, 1 piece/times, blood sugar is in more than 10mmol/L, and glycemic control is very undesirable, occupies height and does not drop, and
And blood glucose value is unstable, often fluctuation occurs in that eye-blurred, and numb limb is done, the sugar such as gastrointestinal dysfunction when dilute during stool
The sick complication of urine, while suffering from hypertension, heart disease etc., after taking this product, progressively withdraws taken medicine thing originally, after one month,
This product is only taken, blood glucose value is down to 5.6mmol/L, and glucose in urine stops, and Urine proteins stop, prostatic function enhancing, evening does not get up in the night to urinate, blood
Sugared value stabilization, does not fluctuate, and after two months, eyesight takes a turn for the better, and trick is not numb, and stool is normal, and blood pressure tends towards stability.
2nd, Kang Meili, female 70 years old, suffers from diabetes 30 years, insulin injection, three times a day, while coordinating oral diformazan double
Guanidine, blood glucose value is influenceed very big by mood, weather, diet etc., and frequent fluctuation, so as to aggravate disease, because blood sugar is high, causes
Pruritus vulvue, shank accidentally after injury, have a sleepless night, irritability by the long-term disunion of wound.Oral this product is after one month, injection of insulin
Progressively halve, after two months, an insulin only injected daily, take this product once a day, 3 bags every time, blood sugar is down to normally,
Wound progressively heals, vulva no longer itch, sleeps, and mood is not irritated, happy.
3rd, Xing Liushu, man, 57 years old, suffers from diabetes 19 years, complicated with diabetes ephrosis, Urine proteins, anasarca, blood glucose value
15mmol/L, its father is diabetes, there is household heredity factors, takes this product, and after one month, Urine proteins stop, blood sugar 6.5mmol/
L, edema is eliminated, muscle power enhancing, can above 6 buildings, and blood indices check normal.
The compound medicine treatment diabetic complication effect of the traditional Chinese and western medicine therapeutic alliance diabetes that the present invention is provided is good.For
The diabetic of eye-blurred, is taken medicine three to six months, and eyesight can be made clear, and fundus hemorrhage stops；The glycosuria of pruitus
Patient, medication takes effect for ten days, antipruritic, two to three months, makes skin smooth, fine and smooth, flexible；Numb in every limb patient of diabetes
Person, takes medicine one or two moon, and brothers are not numb, not bitterly, does not itch, and wound healing accelerates；Nephrosis, one month, eliminates
Urine proteins, gradually recover renal function.
Experiment and case more than, the compound medicine of the traditional Chinese and western medicine therapeutic alliance diabetes of offer of the invention, respectively
Component compatibility science, rationally, low cost can quickly reduce the blood glucose value of diabetic to consumption, keep blood sugar value stabilization
In normal range (NR), various diabetic complications are prevented and treated, with great medical value and application prospect.
The above, specific embodiment only of the invention, but protection scope of the present invention is not limited thereto, ability
Other modifications or equivalent that domain those of ordinary skill is made to technical scheme, without departing from skill of the present invention
The spirit and scope of art scheme, all should cover in the middle of scope of the presently claimed invention.
Claims (2)
1. a kind of compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes, it is characterised in that by the raw material of following weight percentage
Composition：Metformin hydrochloride（Sustained release parcel）1.7% ~ 5%, hydrochloric acid Glimepiride 0.003% ~ 0.04%, Pioglitazone 0.05% ~
0.3%th, pseudo-ginseng 16% ~ 23%, raw oyster 12% ~ 18%, Os Draconis 17% ~ 25%, gypsum 10% ~ 20%, Chinese medical concrete 27% ~ 31%, institute
The Chinese medical concrete stated is made up of the raw material that following weight is matched：6 ~ 10 parts of the Radix Astragali, 7 ~ 12 parts of Radix Codonopsis, 5 ~ 8 parts of kuh-seng, the red sage root 8 ~ 11
Part, 6 ~ 14 parts of radix achyranthis bidentatae, 9 ~ 11 parts of the dried rhizome of rehmannia, 8 ~ 13 parts of cultivated land, 5 ~ 15 parts of Chinese yam, 9 ~ 17 parts of chrysanthemum, 8 ~ 13 parts of the fruit of glossy privet, summer cypress
7 ~ 15 parts of son, 6 ~ 11 parts of dittany bark, 7 ~ 12 parts of rhizoma cyperi, 8 ~ 16 parts of Ligusticum wallichii, 9 ~ 14 parts of rhizoma cibotii, 8 ~ 10 parts of the tuber of dwarf lilyturf, adenophora tetraphylla 6 ~ 10
Part, 5 ~ 12 parts of root of Chinese trichosanthes, 7 ~ 9 parts of radix polygonati officinalis.
2. a kind of preparation method of the compound medicine of traditional Chinese and western medicine therapeutic alliance diabetes according to claim 1, its feature
It is to comprise the following steps that：
（1）The preparation method of Chinese medical concrete：Take 6 ~ 10 parts of the Radix Astragali, 7 ~ 12 parts of Radix Codonopsis, 5 ~ 8 parts of kuh-seng, 8 ~ 11 parts of the red sage root, radix achyranthis bidentatae
6 ~ 14 parts, 9 ~ 11 parts of the dried rhizome of rehmannia, 8 ~ 13 parts of cultivated land, 5 ~ 15 parts of Chinese yam, 9 ~ 17 parts of chrysanthemum, 8 ~ 13 parts of the fruit of glossy privet, 7 ~ 15 parts of the fruit of summer cypress,
6 ~ 11 parts of dittany bark, 7 ~ 12 parts of rhizoma cyperi, 8 ~ 16 parts of Ligusticum wallichii, 9 ~ 14 parts of rhizoma cibotii, 8 ~ 10 parts of the tuber of dwarf lilyturf, 6 ~ 10 parts of adenophora tetraphylla, root of Chinese trichosanthes 5
~ 12 parts, 7 ~ 9 parts of radix polygonati officinalis, to start to decoct after 6 times of h of volume distilled water immersion 2, are heated to boiling, and small fire is continued after boiling
1 h is decocted, is filtered, collect liquid, decocted altogether twice；After the liquid for merging twice carries out decompression low temperature concentration, in paste, dry
It is dry, fine powder is ground into, 100 ~ 150 mesh sieves excessively are standby, and withdrawal ratio is 5:1；
（2）Pseudo-ginseng, raw oyster, Os Draconis, gypsum are taken respectively, impurity elimination is cleaned, fine powder is ground into after drying, cross 100 ~ 200 mesh
It is standby after sieve；
（3）By containing Metformin hydrochloride in every 100 grams of medicines（Sustained release parcel）1.7% ~ 5%, hydrochloric acid Glimepiride 0.003% ~
0.04%th, Pioglitazone 0.05% ~ 0.3%, pseudo-ginseng 16% ~ 23%, raw oyster 12% ~ 18%, Os Draconis 17% ~ 25%, gypsum 10% ~
20%th, the proportioning of Chinese medical concrete 27% ~ 31% weighs each component, and is stirred；
（4）Ball, packing, 10 grams every bag are made by well mixed medicinal powder is general.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115814029A (en) * | 2022-11-17 | 2023-03-21 | 杨杰 | A Chinese and western medicinal composition for treating diabetes |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903323A (en) * | 2005-07-26 | 2007-01-31 | 李展杰 | Capsule for treating diabetes |
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2017
- 2017-04-10 CN CN201710228401.6A patent/CN106902250A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903323A (en) * | 2005-07-26 | 2007-01-31 | 李展杰 | Capsule for treating diabetes |
Non-Patent Citations (1)
| Title |
|---|
| 柳怡等: "补气养阴方二甲双胍结合远红外磁疗治疗糖尿病36例", 《陕西中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115814029A (en) * | 2022-11-17 | 2023-03-21 | 杨杰 | A Chinese and western medicinal composition for treating diabetes |
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