CN105920514A

CN105920514A - Traditional Chinese medicinal composition for treating metabolic syndrome

Info

Publication number: CN105920514A
Application number: CN201610268253.6A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao You Cheng New And High Technology Co Ltd
Current assignee: Qingdao You Cheng New And High Technology Co Ltd
Priority date: 2016-04-27
Filing date: 2016-04-27
Publication date: 2016-09-07

Abstract

The invention discloses a traditional Chinese medicinal composition for treating metabolic syndrome. The traditional Chinese medicinal composition consists of the following components: radix angelicae sinensis, radix notoginseng, ginseng, rhizoma alismatis, lotus leaves, dark plums, fiveleaf gynostemma herb, semen cassiae, platycodon root, liquorice root, fructus xanthii, bulbus allii macrostemi, cassia twig, radix paeoniae alba, radix salviae miltiorrhizae, rhizoma coptidis, fructus crataegi, herba houttuyniae, peach kernels, semen raphani, semen litchi, radix astragali, common dayflower herb, honeysuckle flowers, dandelion, mung beans, aloe, poria cocos, radix stephaniae tetrandrae, herba dianthi, lagenaria siceraria, radix curcumae, herba leonuri, fructus amomi, radix puerariae and folium lycii. The traditional Chinese medicinal composition disclosed by the invention, through the compatibility of the various medicines which complement each other, is effectively applicable to the dialectical treatment of the metabolic syndrome, and the traditional Chinese medicinal composition is capable of improving blood lipid level, relieving insulin resistance and obesity state, and the like. The traditional Chinese medicinal composition disclosed by the invention is convenient to prepare, low in side effect, high in safety and low in cost; and the traditional Chinese medicinal composition provides a technical basis for the research and development of medicines for treating integral metabolic syndrome and complications thereof.

Description

The Chinese medicine composition for the treatment of metabolism syndrome

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to treat the Chinese medicine composition of metabolism syndrome.

Background technology

Metabolism syndrome refers to the pathological state of the material generation metabolism disorders such as the protein of human body, fat, carbohydrate, It is a complex set of metabolism disorder disease group, is the risk factor causing diabetes cardiovascular and cerebrovascular disease.It has the following characteristics that The most multiple metabolism disorder is rolled into one, metabolic arthritis, height glutinous including obesity, hyperglycemia, hypertension, dyslipidemia, high blood Fatty liver incidence rate and hyperinsulinemia, these metabolism disorders are the pathologic basis of the heart, cerebrovascular disease and diabetes. Visible diabetes are not isolated diseases, but one of ingredient of metabolism syndrome.2. there is common pathologic basis, Think that at present their common cause is exactly the obesity insulin resistant that especially central obesity is caused and hyperinsulinemia more Disease.3. multiple disease can be caused to increase, such as hypertension, coronary heart disease, apoplexy, even some cancer, including with gonadal hormone Relevant breast carcinoma, carcinoma of endometrium, carcinoma of prostate, and the cancer of pancreas of digestive system, liver and gall cancer, colon cancer etc..④ There are common prevention and remedy measures, prevent and treat a kind of metabolism disorder, be also advantageous for the preventing and treating of other metabolism disorders.

At present, treatment metabolic syndrome many uses fat regulation medicine, antidiabetic drug, antihypertensive etc. are treated, but every kind of medicine can only pin Some or certain two pathology links to metabolic syndrome.It is of a great variety that this results in patient medication, adds medicine not Good reaction and untoward reaction each other, and add the financial burden of patient, it is unfavorable for long-term treatment.Chinese medicine has many targets The feature of some pharmacological action, it is possible to simultaneously improve insulin resistant, abnormal carbohydrate metabolism, obesity, blood fat disorder etc., and to generation Bad clinical consequences such as atherosclerosis, the diabetes etc. of thanking to syndrome are prevented and treated.It addition, the traditional Chinese medical science also has the side of taking Just, side effect is little, and safety is high, cheap, it is simple to long-term taking and reduce the advantages such as patient economy burden.Though it is existing Having treatment metabolism syndrome multi-medicament, including Chinese medicine, but for various reasons, its use and curative effect are the most unsatisfactory, because of This, treatment metabolism syndrome medicine on improvement and innovate imperative.

Summary of the invention

It is an object of the invention to provide the Chinese medicine composition for the treatment of metabolism syndrome.It is above-mentioned that the mesh of the present invention also resides in offer The preparation method and its usage of the Chinese medicine composition for the treatment of metabolism syndrome.

In order to solve above-mentioned technical problem, the technical solution used in the present invention is as follows: the Chinese medicine composition for the treatment of metabolism syndrome Thing is made up of each raw material components of following parts by weight proportioning:

The Chinese medicine composition for the treatment of metabolism syndrome, is made up of each component of following parts by weight: Radix Angelicae Sinensis 1-15 part, three Seven 1-10 parts, Radix Ginseng 1-8 part, Rhizoma Alismatis 1-10 part, Folium Nelumbinis 5-25 part, Fructus Mume 5-20 part, Herb Gynostemmae Pentaphylli 5-18 part, Semen Cassiae 2-13 part, Radix Platycodonis 2-8 part, Radix Glycyrrhizae 5-20 part, Fructus Xanthii 3-18 part, Bulbus Allii Macrostemonis 5-25 part, Ramulus Cinnamomi 2-11 Part, Radix Paeoniae Alba 2-14 part, Radix Salviae Miltiorrhizae 3-10 part, Rhizoma Coptidis 1-10 part, Fructus Crataegi 4-25 part, Herba Houttuyniae 1-10 part, Semen Persicae 2-6 Part, Semen Raphani 1-6 part, Semen Litchi 2-17 part, Radix Astragali 1-11 part, Herba Commelinae 1-8 part, Flos Lonicerae 1-12 part, Pu Herba Taraxaci 1-12 part, Semen phaseoli radiati 1-12 part, Aloe 1-13 part, Poria 4-12 part, Radix Stephaniae Tetrandrae 2-11 part, Herba Dianthi 1-10 part, Calabash 2-15 part, Radix Curcumae 1-8 part, Herba Leonuri 2-16 part, Fructus Amomi 2-11 part, Radix Puerariae 2-11 part, Folium Lycii 2-25 Part.

Furthermore, preferred each component parts by weight proportioning is:

Radix Angelicae Sinensis 1-11 part, Radix Notoginseng 1-10 part, Radix Ginseng 1-8 part, Rhizoma Alismatis 1-10 part, Folium Nelumbinis 5-25 part, Fructus Mume 5-16 Part, Herb Gynostemmae Pentaphylli 5-15 part, Semen Cassiae 2-10 part, Radix Platycodonis 2-5 part, Radix Glycyrrhizae 5-15 part, Fructus Xanthii 3-15 part, Bulbus Allii Macrostemonis 5-16 part, Ramulus Cinnamomi 2-10 part, Radix Paeoniae Alba 2-14 part, Radix Salviae Miltiorrhizae 3-10 part, Rhizoma Coptidis 1-10 part, Fructus Crataegi 4-16 part, fish raw meat Grass 1-10 part, Semen Persicae 2-6 part, Semen Raphani 1-4 part, Semen Litchi 2-15 part, Radix Astragali 1-10 part, Herba Commelinae 1-8 part, Flos Lonicerae 1-12 part, Herba Taraxaci 1-12 part, Semen phaseoli radiati 1-12 part, Aloe 1-13 part, Poria 4-12 part, Radix Stephaniae Tetrandrae 2-9 Part, Herba Dianthi 1-10 part, calabash 2-15 part, Radix Curcumae 1-8 part, Herba Leonuri 2-16 part, Fructus Amomi 2-11 part, Radix Puerariae 2-10 Part, Folium Lycii 2-16 part.

Furthermore, each component parts by weight proportioning being more highly preferred to is:

Radix Angelicae Sinensis 3 parts, Radix Notoginseng 3 parts, Radix Ginseng 1 part, Rhizoma Alismatis 2 parts, 6 parts of Folium Nelumbinis, Fructus Mume 5 parts, Herb Gynostemmae Pentaphylli 5 parts, Semen Cassiae 3 parts, Radix Platycodonis 4 parts, 6 parts of Radix Glycyrrhizae, Fructus Xanthii 3 parts, Bulbus Allii Macrostemonis 5 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 3 parts, pellet Join 3 parts, Rhizoma Coptidis 1 part, Fructus Crataegi 8 parts, Herba Houttuyniae 6 parts, 3 parts of Semen Persicae, Semen Raphani 1 part, Semen Litchi 6 parts, yellow Stilbene 4 parts, Herba Commelinae 4 parts, Flos Lonicerae 6 parts, Herba Taraxaci 5 parts, 6 parts of Semen phaseoli radiati, Aloe 2 parts, 4 parts of Poria, anti- Oneself 2 parts, Herba Dianthi 2 parts, 2 parts of calabash, Radix Curcumae 2 parts, Herba Leonuri 7 parts, Fructus Amomi 6 parts, Radix Puerariae 3 parts, Folium Lycii 7 parts.

Radix Angelicae Sinensis 2 parts, Radix Notoginseng 2 parts, Radix Ginseng 1 part, Rhizoma Alismatis 3 parts, 10 parts of Folium Nelumbinis, Fructus Mume 6 parts, Herb Gynostemmae Pentaphylli 6 parts, Semen Cassiae 4 parts, Radix Platycodonis 2 parts, 7 parts of Radix Glycyrrhizae, Fructus Xanthii 3 parts, Bulbus Allii Macrostemonis 7 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 5 parts, pellet Join 3 parts, Rhizoma Coptidis 1 part, Fructus Crataegi 6 parts, Herba Houttuyniae 2 parts, 3 parts of Semen Persicae, Semen Raphani 2 parts, Semen Litchi 8 parts, yellow Stilbene 2 parts, Herba Commelinae 2 parts, Flos Lonicerae 6 parts, Herba Taraxaci 4 parts, 3 parts of Semen phaseoli radiati, Aloe 5 parts, 4 parts of Poria, anti- Oneself 3 parts, Herba Dianthi 4 parts, 6 parts of calabash, Radix Curcumae 7 parts, Herba Leonuri 9 parts, Fructus Amomi 3 parts, Radix Puerariae 4 parts, Folium Lycii 7 parts.

Medicine of the present invention can be prepared as acceptable decoction, capsule on any pharmaceutics according to the common process of this area One in agent, pill, tablet, powder, oral liquid, granule.

It addition, present invention also offers the preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, including following step Rapid: by described crude drug boiling twice, add water 5-10 times amount for the first time, boils 1-5 hour；Second time adds water 4-8 times amount, boils 0.5-3 hour, collecting decoction, filters, and in 55 DEG C, filtrate is concentrated into proportion is 1.14-1.47, Release concentrated solution, dilute, stand 24 hours, take supernatant and cross 300-400 mesh filter screen, concentrate, add appropriate tax Shape agent, is spray dried to granule；It is distributed into pouch, obtains powder.

Other preferred dosage form of the present invention also can be prepared as follows method and make: by described crude drug boiling twice, the Once add water 5-10 times amount, boils 1-5 hour；Add water 4-8 times amount for the second time, boils 0.5-3 hour, collecting decoction, Filtering, in 55 DEG C, filtrate is concentrated into proportion is 1.14-1.47, releases concentrated solution, dilute, stands 24 hours, Take supernatant and cross 300-400 mesh filter screen, concentrate, the most routinely preparation process be respectively prepared corresponding capsule, pill, Tablet, powder, oral liquid or granule.

Present invention additionally comprises the Chinese medicine composition of described treatment metabolism syndrome or described Chinese medicine composition with pharmaceutically The application in the pharmaceutical preparation of preparation treatment metabolism syndrome of the acceptable pharmaceutical carrier.

Present invention additionally comprises described Chinese medicine composition or described Chinese medicine composition and pharmaceutically acceptable pharmaceutical carrier In preparation treatment abnormal carbohydrate metabolism, central obesity, hypertension, hyperlipemia or the medicine system of atheromatosis Application in agent.

By technique scheme, the present invention has the advantage that and provides the benefit that: all medicine compatibilities of the present invention, benefits mutually Evident, can be effectively used for dialectical treatment metabolism syndrome, improve blood lipid level, alleviate insulin resistant and fat state etc.. The present invention is easy to make, side effect is little, safety is high, cheap, entirety and complication for metabolism syndrome are controlled The research and development treating medicine provides technical foundation.

Detailed description of the invention

The core that the application is claimed, with it is crucial that the compatibility of Chinese medicine composition, does not lies in dosage form, every this Chinese medicine of employing Any dosage form that compositions is made, belongs to the scope that the present invention is claimed.Its raw material components comprised is: Radix Angelicae Sinensis, Radix Notoginseng, Radix Ginseng, Rhizoma Alismatis, Folium Nelumbinis, Fructus Mume, Herb Gynostemmae Pentaphylli, Semen Cassiae, Radix Platycodonis, Radix Glycyrrhizae, Fructus Xanthii, Bulbus Allii Macrostemonis, Ramulus Cinnamomi, The Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Rhizoma Coptidis, Fructus Crataegi, Herba Houttuyniae, Semen Persicae, Semen Raphani, Semen Litchi, the Radix Astragali, Herba Commelinae, Flos Lonicerae, Herba Taraxaci, Semen phaseoli radiati, Aloe, Poria, Radix Stephaniae Tetrandrae, Herba Dianthi, calabash, Radix Curcumae, Herba Leonuri, Fructus Amomi, Radix Puerariae, Folium Lycii.

Wherein, main component and effect of each Chinese medicinal components is described below respectively:

Radix Angelicae Sinensis: sweet in the mouth is pungent, temperature, can rise and can drop, the YIN aspect of YANG is nontoxic.Though there being upper purgation to divide, enrich blood then one. Dong Yuan calls tail removing blood stasis person, by mistake.Enter the heart, spleen, liver three dirty.But its property is the most dynamic, then QI invigorating, the benefit entered in the Qi-tonifying drug entered Blood medicine is then enriched blood, the ascending medicine entered then carries gas, the fall entered by medicine then by blood also.And with cold then tremble with fear, use it Re Zere, without determining merit also.

Radix Notoginseng: nature and flavor: hardship sweet, micro-, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain. For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Radix Ginseng: nature and flavor: hardship sweet, micro-is flat.Gui Jing: return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, multiple arteries and veins Gu de-, invigorating the spleen to benefit the lung, promotes the production of body fluid, calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin is hindered Thirsty, interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb；Heart failure, cardiogenic shock.

Rhizoma Alismatis: nature and flavor: sweet, cold.Gui Jing: return kidney, bladder warp.Function cures mainly: diuresis, clearing away damp-heat.For little The most unfavorable, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria；Hyperlipidemia.

Folium Nelumbinis: nature and flavor: bitter is flat.Gui Jing: return liver, spleen, stomach warp.Function cures mainly: clearing away summer-heat, sending up the lucid YANG, Cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood tells nosebleed, metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy The stasis of blood is stopped blooding.For multiple hemorrhage and puerperal blood faints.

Fructus Mume: nature and flavor: sour, puckery is flat.Gui Jing: return liver, spleen, lung, large intestine channel.Function cures mainly: astringe the lung, astringing intestine to stop diarrhea, Promote the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat quenches one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.

Herb Gynostemmae Pentaphylli: nature and flavor: bitter in the mouth；Micro-sweet；Cool in nature.Gui Jing: return lung；Spleen；Kidney channel.Function cures mainly: heat clearing away；Mend Empty；Removing toxic substances.Main body void is weak；Nephrasthenia emission；Leukopenia；Hyperlipemia；Viral hepatitis；Chronic gastrointestinal Scorching；Chronic tracheitis.

Semen Cassiae: nature and flavor: sweet, bitter, salty, is slightly cold.Gui Jing: return liver, large intestine channel.Function cures mainly: clearing away heat to improve acuity of vision, Loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, poor vision, constipation.

Radix Platycodonis: nature and flavor: bitter, pungent is flat.Gui Jing: return lung meridian.Function cures mainly: lung qi dispersing, and sore-throat relieving eliminates the phlegm, evacuation of pus. For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Radix Glycyrrhizae: nature and flavor: sweet, flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " book on Chinese herbal medicine Spread out justice ": " micro-cool." 4. " pearl sac ": " is raw sweet, flat；Process sweet, temperature." return through: enter spleen, stomach, lung meridian.① Materia Medica of Decoction: " enter sufficient cloudy, lunar, shaoyin channel of fainting." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen two warp." 3. " explaining abstruseness of the canon of materia medica ": " enter spleen, stomach." 4. " book on Chinese herbal medicine is through solving ": " enters lung meridian, spleen meridian." function Cure mainly: and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain, overstrain Heating, consumptive lung disease cough, cardiopalmus, infantile convulsion；Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, solve poison of drug and Alimentary toxicosis.1. " herbal classic ": " main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, long muscle, times power, incised wound swells, and solves Poison." 2. " not Lu ": " warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, quenches the thirst, qualcomm meridian, profit vim and vigour, solves hundred medicines Poison."

Fructus Xanthii: nature and flavor: sweet, temperature, poisonous.1. " herbal classic ": " sweet in the mouth, temperature." 2. " not Lu ": " be bitter."③ " product remittance essence is wanted ": " bitter but sweet flavor, warm in nature, slightly poisonous." return through: enter lung, Liver Channel.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " beautiful Chinese catalpa medicine solution ": " enters liver channel of foot-Jueyin." 3. " book on Chinese herbal medicine is looked for the truth ": " enters liver, spleen." 4. " meeting About cure mirror ": " enter liver, kidney two warp." function cures mainly: dissipate wind, pain relieving, damp eliminating, parasite killing.Control headche due to wind-cold, nasal sinusitis, Toothache, anemofrigid-damp arthralgia, limb pain twin, mange, pruritus.

Bulbus Allii Macrostemonis: nature and flavor: pungent, bitter, temperature.Gui Jing: return lung, stomach, large intestine channel.Function cures mainly: activating YANG and eliminating stagnation, circulation of qi promoting Intestinal stasis relieving.For thoracic obstruction pain, phlegm retention cough with asthma, let out weight after dysentery.

Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, bladder warp.Function cures mainly: diaphoresis expelling pathogenic factors from muscles, Wen Tong Passages through which vital energy circulates, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, Edema, cardiopalmus, renal mass.

The Radix Paeoniae Alba: nature and flavor: picric acid is cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " paulownia monarch: sweet, Nontoxic.Qi primary: salty.Li Shi: the Slight Cold.Thunder God: acid." 3. " not Lu ": " acid, flat is slightly cold, slightly poisonous." return through: Enter liver, spleen channel.1. " product remittance essence is wanted ": " row hands is lunar, meridian of Foot-TAI YIN." 2. " Bencao Jingshu ": " brothers are lunar draws Through medicine, enter liver, spleen blood system." function cures mainly: nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing receives antiperspirant.Control the chest and abdomen pain over the hypochondriac region, Dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.

Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clearly Heart relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, vexed Sleeplessness；Hepatosplenomegaly, angina pectoris.

Rhizoma Coptidis: nature and flavor: bitter, cold.Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing away is dry Wet, eliminating fire and detoxication.For damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, vexed not Sleeping, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.Rhizoma Coptidis (processed with wine) is apt to The clear part of the body cavity above the diaphragm housing the heart and lungs is burning hot.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness Vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomit acid regurgitation.

Fructus Crataegi: nature and flavor: sour, sweet, tepor.Gui Jing: return spleen, stomach, Liver Channel.Function cures mainly: promoting digestion and invigorating the stomach, circulation of qi promoting Dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia is ached Bitterly；Hyperlipemia.Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving effect strengthens.For meat stagnation, dysentery is not well.

Herba Houttuyniae: nature and flavor: pungent, is slightly cold.Gui Jing: return lung meridian.Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, diuresis Treating stranguria.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.

Semen Persicae: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic."③ " a thousand pieces of gold dietetic therapy ": " bitter but sweet flavor is pungent, flat, nontoxic." return through: enter the heart, liver, large intestine channel.Function cures mainly: removing blood stasis Clots absorbing, moisturizes laxation.Controlling amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, blood is dry Constipation.

Semen Raphani: nature and flavor: acrid in the mouth；Sweet；Property flat.Gui Jing: spleen；Stomach；Lung；Large intestine channel.Function cures mainly: helps digestion and leads Stagnant；Lowering the adverse-rising QI to resolve phlegm.Main stagnation of QI due to dyspepsia；Distension and fullness in the abdomen；Diarrhoea；Weight after dysentery；Cough ant phlegm；QI rising in reverse order dyspnea with fullness of the chest.

Semen Litchi: the dry mature seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn..Summer harvesting ripe Fruit, removes peel and meat aril, cleans, dries.Nature and flavor: sweet puckery, temperature.1. " detailed outline ": " sweet, temperature, Puckery, nontoxic." 2. " medical center bun is wanted ": " is sweet puckery, and temperature is micro-salty." 3. " Guangxi Chinese medicinal herbal ": " sweet and slightly bitter taste is puckery, and property is put down, Nontoxic." return through: enter liver, kidney channel.1. " detailed outline ": " enter the moon of fainting." 2. " Bencao Jingshu ": " enters liver, kidney." 3. " this Grass brief points ": " enter lunar, the JUE YIN meridian of foot." function cures mainly: warming middle-JIAO, regulates the flow of vital energy, pain relieving.Control gastric abscess, colicky, woman Female's pricking caused by the stagnation of QI and blood.1. control the long pain of trusted subordinate's gastral cavilty, touch originator repeatly repeatly: Semen Litchi one money, the Radix Aucklandiae eight points.For end.Often take one Money, clear soup is taken after mixing with liquid.(Jing-Yue Complete Works litchi perfume (or spice) dissipate) 2. controls pained and small intestine-QI: Semen Litchi one piece.Forging sustainability, wine is adjusted Clothes, (amplification on Canon of Materia Medica) 3. controls kidney greatly such as bucket: Fructus Foeniculi, Pericarpium Citri Reticulatae Viride (full person), Semen Litchi decile on oceangoing ship.File dissipates, and fries, Go out fire-toxin, for end.Two money under wine, taking medicine three times daily.(Effective Formulas Tested by Physicians for Generations litchi core dissipates) is 4. controlled hernia TUI and is swollen: Semen Litchi Four nineteens, Pericarpium Citri Reticulatae (the whitest) nine money, sulfur four money, for end, it is big that lake, face ball Semen phaseoli radiati bought by saline.When meeting pain, hollow wine Take nine balls, take the most again, also control all pain due to disorder of QI.(" smooth celestial being all efficacious prescriptions " Yuhuan reflex is red) 5. controls pricking caused by the stagnation of QI and blood: Semen Litchi (burns Sustainability) half two, Rhizoma Cyperi one or two.Upper for end.Often taking two money, salt wine send down.

The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, Expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, gas Empty edema, carbuncle difficulty is burst, and bursts for a long time and does not holds back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, diabetes.

Herba Commelinae: nature and flavor: sweet, light, cold.Gui Jing: return lung, stomach, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, profit Water is subsided a swelling.For anemopyretic cold, hyperpyrexia, laryngopharynx swelling and pain, edema oliguria, the puckery pain of pyretic stranguria, carbuncle furunculosis.

Flos Lonicerae: nature and flavor: sweet, cold.Gui Jing: return lung, the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating. For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.

Herba Taraxaci: nature and flavor: bitter sweet, cold.1. Tang Materia Medica: " sweet in the mouth, flat, nontoxic." 2. Li Gao: " micro-hardship, cold. " 3. " book on Chinese herbal medicine is stated ": " is sweet, puts down and is slightly cold." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " is bitter sweet, cold." return through: Enter liver, stomach warp.1. Li Gao: " meridian of Foot-SHAO YIN." 2. " Amplification on Materia Medica addendum ": " enters bright, the Taiyin channels of sun." function master Control: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, Cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Semen phaseoli radiati: nature and flavor: sweet, cold.Gui Jing: enter the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, relieves summer heat.For summer-heat Excessive thirst, the disease such as sore carbuncle.Radix Aconiti Lateralis Preparata, Fructus Crotonis poison can be solved.

Aloe: nature and flavor: bitter, cold.Gui Jing: return liver, stomach, large intestine channel.Function cures mainly: removing heat from the liver, relieving constipation.For Constipation, infantile malnutrition, infantile convulsion；External treatment exudative dermatitis.

Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, strong Spleen mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, irritability, palpitation with fear insomnia.

Radix Stephaniae Tetrandrae: nature and flavor: bitter, cold.Gui Jing: return bladder, lung meridian.Function cures mainly: inducing diuresis to remove edema, wind-expelling pain-stopping.With In edema tinea pedis, dysuria, eczema sore, rheumatic arthralgia；Hypertension.

Herba Dianthi: nature and flavor: bitter；Cold in nature.Gui Jing: the heart；Liver；Small intestinal；Bladder warp.Function cures mainly: diuresis；The wettest Heat；Promoting blood circulation to restore menstrual flow.Main urinary obstruction；Pyretic stranguria；Stranguria with blood；Stranguria caused by urinary stone；Amenorrhea；Conjunctival congestion and swelling pain；Carbuncle sore tumefacting virus；Eczema scabies Itch.

Calabash: sweet in the mouth, light, cold in nature.The moon is also.Cold stomach, dynamic cold disease.Having cold disease to eat it, tripe abdomen aches, send out rheumatism in abdomen, Accumulation of phlegm.Have winddamp phlegm food stagnation it, send rubella, pruritus, unsuitable polyphagia.Cure mainly antipyretic, relieving restlessness, lung moistening, treating stranguria, Diuresis, polyphagia makes us vomiting and diarrhea foot pain.

Radix Curcumae: nature and flavor: pungent, bitter, cold.Gui Jing: return liver, the heart, lung meridian.Function cures mainly: regulating qi to disperse stagnation, and clear away heart-fire solution Strongly fragrant, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy goes mad, jaundice dark coloured urine.

Herba Leonuri: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, diuresis Detumescence.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria；Acute nephritis edema.

Fructus Amomi: nature and flavor: pungent, temperature.Gui Jing: return spleen, stomach, kidney channel.Function cures mainly: removing dampness is whetted the appetite, warming spleen and stopping diarrha, Regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is the most hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.

Radix Puerariae: nature and flavor: sweet, pungent is cool.Gui Jing: return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, Yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels；High blood Pressure neck pain.

Folium Lycii: there is antipyretic, the treatment curative effect such as diabetes, relieving cough and resolving phlegm, effect: the liver and the kidney tonifying, only promote the production of body fluid Yearningly, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.Control deficient fever, excessive thirst, conjunctival congestion dusk pain, nyctalopia of hiding from view, bleeding not during menses, pyretic toxicity Skin ulcer swells.

Below by way of concrete preferred embodiment, the present invention is described in further detail, but the present invention is not limited in following Embodiment.

Embodiment 1

The preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprises the following steps: added water by described crude drug Decocting twice, add water 5 amounts for the first time, when boiling 2；Add water 5 amounts, when boiling 2, collecting decoction for the second time, filters, In 55 DEG C, filtrate is concentrated into proportion is 1.14, releases concentrated solution, dilute, stands 24 hours, take supernatant mistake 300-400 mesh filter screen, concentrates, adds appropriate excipient, be spray dried to granule；It is distributed into pouch, obtains powder.

Embodiment 2

The preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprises the following steps: added water by described crude drug Decocting twice, add water 5 amounts for the first time, when boiling 2；Add water 4 amounts, when boiling 1, collecting decoction for the second time, filters, In 55 DEG C, filtrate is concentrated into proportion is 1.47, releases concentrated solution, dilute, stands 24 hours, take supernatant mistake 300-400 mesh filter screen, concentrates, and preparation process makes corresponding capsule the most routinely.

Embodiment 3

Radix Angelicae Sinensis 2 parts, Radix Notoginseng 2 parts, Radix Ginseng 1 part, Rhizoma Alismatis 3 parts, 10 parts of Folium Nelumbinis, Fructus Mume 6 parts, Herb Gynostemmae Pentaphylli 6 parts, Semen Cassiae 4 parts, Radix Platycodonis 2 parts, 7 parts of Radix Glycyrrhizae, Fructus Xanthii 3 parts, Bulbus Allii Macrostemonis 7 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 5 parts, pellet Join 3 parts, Rhizoma Coptidis 1 part, Fructus Crataegi 6 parts, Herba Houttuyniae 2 parts, 3 parts of Semen Persicae, Semen Raphani 2 parts, Semen Litchi 8 parts, yellow Stilbene 2 parts, Herba Commelinae 2, Flos Lonicerae 6, Herba Taraxaci 3, Semen phaseoli radiati 2, Aloe 2, Poria 4, Radix Stephaniae Tetrandrae 2, Herba Dianthi 2, calabash Reed 3, Radix Curcumae 2, Herba Leonuri 3, Fructus Amomi 2, Radix Puerariae 3, Folium Lycii 4.

The preparation method of the Chinese medicine composition of above-mentioned treatment metabolism syndrome, comprises the following steps: added water by described crude drug Decocting twice, add water 5 amounts for the first time, when boiling 2；Add water 4 amounts, when boiling 1, collecting decoction for the second time, filters, In 55 DEG C, filtrate is concentrated into proportion is 1.47, releases concentrated solution, dilute, stands 24 hours, take supernatant mistake 300-400 mesh filter screen, concentrates, and preparation process makes pill the most routinely.

Toxicity test

Taking West Germany rabbit 80, male and female half and half, body weight 2.0-3.0kg, divide two groups, often group 40, one of which is super large Dosetest group, another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, gives Prescription formula is that administration by gavage is administered, and every day, secondary, serve on 7 days, observes every day and is administered reaction, and result shows that two groups of rabbit live Dynamic, diet normal, medicine is without bad toxic and side effects.

One, blood fat reducing effect experiment

Materials and methods

1.1 material: laboratory animal takes 3 week old ablactation male Wister rats, body weight 55 ± 10g.

1.2 animal packet and 70 rats of method are randomly divided into Normal group, high fat high salt (model) group, diformazan is double Guanidine group, atorvastatin group, the present composition high, medium and low dosage group, totally 7 groups, every treated animal 10.Just Often control animals gives normal diet, and other respectively organize rat all with high fat (49% Adeps Sus domestica) high salt (4% sodium chloride) feedstuff Feeding, each group rat drinks normal saline, feeds 8 weeks continuously.And fill respectively in modelling each administration on same day group rat Stomach gives Drug therapy, and once a day, wherein atorvastatin group gives atorvastatin 8mg/kg, and blood sugar lowering group gives Metformin 670mg/kg, Chinese medicine low (TCM-H), in (TCM-M), high (TCM-L) dosage component do not give Give and be equivalent to crude drug amount 2g/kg, 4g/kg, 8g/kg body weight present composition.Put to death animal fasted for one day prior and can't help water, Experiment terminates, and abdominal vein takes blood, detects serum insulin, insulin resistance index.

1.3 statistical procedures the data obtaineds are analyzed through statistics software SPSS13.0.Each group data are all with ± s table Show that multiple comparisons one factor analysis of variance between measurement data sample average compares between group and checks with t.P ＜ 0.05 For statistically significant.

2. experimental result

Result shows, compares with model group and atorvastatin group, and the present composition all can obviously reduce metabolism syndrome Rat blood serum insulin level and insulin resistance index (P ＜ 0.05 or 0.01)

Table 1 present composition is on rats with metabolic syndrome serum insulin and the impact of insulin resistance index

Packet	INS(mU/L)	HONA-IR
			Normal group	0.672±0.141※	1.75±0.352※
Model group	0.905±0.235※	2.65±0.472
			Metformin	0.660±0.173※	1.93±0.287※
Atorvastatin	0.823±0.210	2.30±0.421
			TCM-H	0.616±0.150※※⊿	1.87±0.349※※⊿
TCM-M	0.669±0.123※⊿	1.79±0.413※⊿
			TCM-L	0.616±0.150※⊿	1.86±0.331※⊿

Compare with model group, * P < 0.05；**P<0.01.△ P < 0.05 is compared with atorvastatin group.Experiment shows, Chinese medicine composition of the present invention has significant impact to rat blood serum insulin and insulin resistance index, can be effectively used for treatment Metabolism syndrome, and try out through clinical practice, achieve very satisfied Advantageous Effects.

Two, the clinical observation of Drug therapy metabolism syndrome of the present invention

The medication combined fasting of the present invention observes 68 example Metabolic Syndrome Patients clinically, and result shows this medication combined taboo Food has good therapeutic effect to overweight/obesity and associated metabolic disease.Hypoglycemia is had no during use Reaction and other untoward reaction.

(1) diabetes branch of Chinese Medical Association (CSS) diagnostic criteria in 2004 is pressed in metabolic syndrome diagnostic criteria: tool Standby following 3 or above person.(1) overweight and (or) fat: BMI >=25kg/m2；(2) blood fat disorder: on an empty stomach Blood TG >=1.7mmol/L, and (or) fasting blood HDL-C man ＜ 0.9mmol/L or female ＜ 1.0mmol/L person, (or) make a definite diagnosis blood fat disorder person；(3) hyperglycemia: FPG >=6.1mmol/L (110mg/dl) and (or) 2hPG >= 7.8mmol/L (140mg/dl), (or) person that is diagnosed as treating diabetes；(4) hypertension: SBP/DBP >= 140/90mmHg, and (or) it is diagnosed as hyperpietic.

(2) case inclusive criteria

1 diagnostic criteria meeting metabolic syndrome；Between 2 age 18-70 years.

(3) case exclusion standard

1 age is under-18s or the patient of more than 70 years old；2 have Diabetic Acute complications (bag in nearly 1 month Include in diabetic Hypoglycemia, diabetic hyperosmolar coma, Diabetic ketosis and ketoacidosis, diabetes lactate acid Poison, Diabetic Acute infect)；3 merge the infull patient of severe cardiac, Liver and kidney function；4 mental diseases fail partner； 5 pregnant or age of sucking and preparation gravid woman；6 noncooperationists (refer to coordinate fasting maybe can not take Chinese medicine by regulation And the person of affecting the treatment)；7 malignant tumor and inpatient with haematological diseases；8 active tuberculosis patients；Bursting of 9 serious gastrorrhagias Infections patient；101 diabetes mellitus types；112 patients with type Ⅰ DM control bad, need insulin injection patient；12 is primary Property hypertension enalapril meleate control the best, secondary hypertension patient；13 researcheres are deemed unsuitable for into other of group Situation.

(4) all patients of Therapeutic Method all sign Informed Consent Form before starting treatment, all on the basis maintaining former treatment On, carry out fasting (strict diet control) and add this Chinese medicine, one month course for the treatment of.

(5) observation index

1 curative effect index body weight, waistline, blood pressure, blood fat, change of blood sugar.

2 safety indexes hypoglycemic incidence, hunger intensity and curative compliance, hepatic and renal function, routine blood test.

(6) Comprehensive Clinical the standard of curative effect evaluation

Effective: weight loss more than 3.5 kilograms after month, blood fat, blood glucose, blood pressure are obviously improved the most earlier above.

Effective: weight loss more than 2 kilograms after month, improve before the most relatively fasting of blood fat, blood glucose, blood pressure.

Invalid: not reach above standard person.

(7) result

1 body weight and waistline change

In 68 example overweight/obesity persons, male's weight average declines more than 6 kilograms；Women averagely decline 10 kilograms with On；Women waistline declines inconspicuous, may be more with women waist and belly capsule meat, measures not accurate enough relevant.

2 Blood Lipid

Project	Number	Before treatment	After treatment
				TC(mmom/L)	68	7.13±1.03	4.03±0.37
HDL-c(mmom/L)	68	0.87±0.19	1.32±0.29
				LDL-c(mmom/L)	68	4.18±0.86	2.19±0.17
TG(mmom/L)	68	5.96±1.14	1.53±1.01

3 change of blood sugar

Project	Number	Before treatment	After treatment
				FBG(mmom/L)	68	9.1±2.3	6.2±1.1
P0.5hBG(mmom/L)	68	13.9±4.9	9.6±2.1
				P2hBG(mmom/L)	68	11.9±3.1	6.9±1.4

4 Evaluation of Synthetic Effect of Holistics

The medication combined fasting of the present invention observes 68 example Metabolic Syndrome Patients, the most effective 43 examples, effective 24 examples, nothing clinically Imitate 1 example.

The medication combined fasting of the present invention has good therapeutic effect to metabolism syndrome, and without obvious adverse reaction；Permissible The ability of patient resistance to hunger is greatly improved and accepts the compliance of diet control.

The above, be only presently preferred embodiments of the present invention, and the present invention not makees any pro forma restriction, therefore Every without departing from technical solution of the present invention content, according to the technical spirit of the present invention above example is made any simply Amendment, equivalent variations and modification, all still fall within the range of technical solution of the present invention.

Claims

1. treat the Chinese medicine composition of metabolism syndrome, it is characterised in that: it is made up of each component of following parts by weight: Radix Angelicae Sinensis 1-15 part, Radix Notoginseng 1-10 part, Radix Ginseng 1-8 part, Rhizoma Alismatis 1-10 part, Folium Nelumbinis 5-25 part, Fructus Mume 5-20 part, Herb Gynostemmae Pentaphylli 5-18 part, Semen Cassiae 2-13 part, Radix Platycodonis 2-8 part, Radix Glycyrrhizae 5-20 part, Fructus Xanthii 3-18 part, Bulbus Allii Macrostemonis 5-25 Part, Ramulus Cinnamomi 2-11 part, Radix Paeoniae Alba 2-14 part, Radix Salviae Miltiorrhizae 3-10 part, Rhizoma Coptidis 1-10 part, Fructus Crataegi 4-25 part, Herba Houttuyniae 1-10 Part, Semen Persicae 2-6 part, Semen Raphani 1-6 part, Semen Litchi 2-17 part, Radix Astragali 1-11 part, Herba Commelinae 1-8 part, Flos Lonicerae 1-12 part, Herba Taraxaci 1-12 part, Semen phaseoli radiati 1-12 part, Aloe 1-13 part, Poria 4-12 part, Radix Stephaniae Tetrandrae 2-11 part, Qu Wheat 1-10 part, calabash 2-15 part, Radix Curcumae 1-8 part, Herba Leonuri 2-16 part, Fructus Amomi 2-11 part, Radix Puerariae 2-11 part, Folium Lycii 2-25 part.

The Chinese medicine composition for the treatment of metabolism syndrome the most according to claim 1, it is characterised in that: it is by following Each component composition of parts by weight:

4. the Chinese medicine composition of the treatment metabolism syndrome according to any one of claim 1-3, it is characterised in that: when Return 2 parts, Radix Notoginseng 2 parts, Radix Ginseng 1 part, Rhizoma Alismatis 3 parts, 10 parts of Folium Nelumbinis, Fructus Mume 6 parts, Herb Gynostemmae Pentaphylli 6 parts, Semen Cassiae Son 4 parts, Radix Platycodonis 2 parts, 7 parts of Radix Glycyrrhizae, Fructus Xanthii 3 parts, Bulbus Allii Macrostemonis 7 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 5 parts, Radix Salviae Miltiorrhizae 3 Part, Rhizoma Coptidis 1 part, Fructus Crataegi 6 parts, Herba Houttuyniae 2 parts, 3 parts of Semen Persicae, Semen Raphani 2 parts, Semen Litchi 8 parts, the Radix Astragali 2 Part, Herba Commelinae 2 parts, Flos Lonicerae 6 parts, Herba Taraxaci 4 parts, 3 parts of Semen phaseoli radiati, Aloe 5 parts, 4 parts of Poria, Radix Stephaniae Tetrandrae 3 Part, Herba Dianthi 4 parts, 6 parts of calabash, Radix Curcumae 7 parts, Herba Leonuri 9 parts, Fructus Amomi 3 parts, Radix Puerariae 4 parts, Folium Lycii 7 parts.

5. according to the Chinese medicine composition of the treatment metabolism syndrome according to any one of claim 1-4, it is characterised in that: Dosage form is the one in decoction, capsule, pill, tablet, powder, oral liquid, granule.

6. according to the preparation method of the Chinese medicine composition treating metabolism syndrome according to any one of claim 1-5, It is characterized in that: comprise the following steps: by described crude drug boiling twice, add water 5-10 times amount for the first time, boils Boil 1-5 hour；Add water 4-8 times amount for the second time, boils 0.5-3 hour, collecting decoction, filters, by filtrate in 55 DEG C Being concentrated into proportion is 1.14-1.47, releases concentrated solution, dilute, stands 24 hours, take supernatant and cross 300-400 mesh Filter screen, concentrates, adds appropriate excipient, be spray dried to granule；It is distributed into pouch, obtains powder.

7. according to the preparation method of the Chinese medicine composition treating metabolism syndrome according to any one of claim 1-6, It is characterized in that: comprise the following steps: by described crude drug boiling twice, add water 5-10 times amount for the first time, boils Boil 1-5 hour；Add water 4-8 times amount for the second time, boils 0.5-3 hour, collecting decoction, filters, by filtrate in 55 DEG C Being concentrated into proportion is 1.14-1.47, releases concentrated solution, dilute, stands 24 hours, take supernatant and cross 300-400 mesh Filter screen, concentrates, and preparation process is respectively prepared corresponding capsule, pill, tablet, powder, oral liquid the most routinely Or granule.

The Chinese medicine composition for the treatment of metabolism syndrome the most according to claim 1 or described Chinese medicine composition and medicine Acceptable pharmaceutical carrier application in the pharmaceutical preparation of preparation treatment metabolism syndrome on.

Application the most according to claim 8, it is characterised in that described Chinese medicine composition or described Chinese drug-treated group Compound and pharmaceutically acceptable pharmaceutical carrier are at preparation treatment abnormal carbohydrate metabolism, central obesity, hypertension, hyperlipemia Application in the pharmaceutical preparation of disease or atheromatosis.