CN108619355A - A kind of antitumor Chinese and preparation method thereof - Google Patents
A kind of antitumor Chinese and preparation method thereof Download PDFInfo
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- CN108619355A CN108619355A CN201810813409.3A CN201810813409A CN108619355A CN 108619355 A CN108619355 A CN 108619355A CN 201810813409 A CN201810813409 A CN 201810813409A CN 108619355 A CN108619355 A CN 108619355A
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Abstract
The invention discloses a kind of antitumor Chineses, including following raw material：Take rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Fructus Liquidambaris, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony.Preparation method is：Following raw material is weighed respectively and takes rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Fructus Liquidambaris, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, is crushed by micronizer after mixing；Particle is added water to cook and obtains decocting liquid three times, is filtered after the liquid decocted three times is merged, filtrate is extracted after filtering, filtrate is concentrated under reduced pressure and obtains concentrate；Auxiliary material is added into concentrate, and oral solution, capsule, tablet or granule is made.Chinese medicine composition provided by the invention has a wide range of application, and has no toxic side effect, quick, and recurrent is low, can effectively immunosupress, antitumor.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, and in particular to a kind of antitumor Chinese, the invention further relates to
The preparation method of the Chinese medicine composition.
Background technology
Tumour (Tumor) is body under the effect of various carcinogenic factors, some cell of local organization is in gene level
On lose normal regulation to growth, lead to its clonal abnormality hyperplasia and the abnormality that is formed.Educational circles is generally by tumour
It is divided into benign and malignant two major classes.Tumour has become the number one killer for 21 century threatening human survival, there is more than 600 ten thousand every year on average
People dies of various tumor diseases.China is one of world's cancer country occurred frequently, and is presented a rapidly rising trend every year.
Clinically the drug for the treatment of tumour mainly has chemicals at present, but since chemotherapeutics toxicity is big, swollen killing
Also human autoimmunes' cell such as kill leucocyte, lymphocyte of non-selectivity while oncocyte, cause patient usually by
It is complicated by infection in because of autoimmunity inferior capabilities, patient uses erious adverse reaction, and the course for the treatment of is long, costly, in Clinical practice
There is larger limitation.
Traditional Chinese medicine has unique advantage in terms for the treatment of tumour, has poison is secondary to make by the natural class drug of representative of Chinese medicine
With the features such as small, action target spot is various, tolerance is good, more and more it is taken seriously in terms for the treatment of tumour.But existing Chinese medicine
Medicine treats tumour, the unconspicuous defect of generally existing slowly effect, effect.
Invention content
The object of the present invention is to provide a kind of antitumor Chinese, which has a wide range of application, nontoxic pair
Effect, and quick, recurrent is low, can effectively immunosupress, antitumor.
It is a further object of the present invention to provide a kind of preparation methods of antitumor Chinese.
The technical solution adopted in the present invention is that a kind of antitumor Chinese includes each group of following mass fraction
Point：Rhizoma cyperi：20~30 parts, radix tetrastigme：10~30 parts, lance asiabell root：10~25 parts, corydalis tuber：5~15 parts, Radix Salviae Miltiorrhizae：8~16 parts,
Fingered citron：20~30 parts, ginkgo leaf：15~30 parts, myrrh：10~20 parts, herba aristolochiae：5~12 parts, Fructus Liquidambaris：9~20 parts, certainly
Pine torch：15~25 parts, pueraria lobata：7~18 parts, Radix Notoginseng：15~26 parts, garden burnet：10~20 parts, cacumen biotae：10~22 parts, red crowned crane
Grass：3~15 parts.
Another technical solution of the present invention is that a kind of preparation method of antitumor Chinese is specifically pressed
Implement according to following steps：
Step 1, rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Lu Lu are taken
Logical, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2, rhizoma cyperi is weighed respectively according to mass fraction：20~30 parts, radix tetrastigme：10~30 parts, lance asiabell root：10~25
Part, corydalis tuber：5~15 parts, Radix Salviae Miltiorrhizae：8~16 parts, fingered citron：20~30 parts, ginkgo leaf：15~30 parts, myrrh：10~20 parts, day
Celestial rattan：5~12 parts, Fructus Liquidambaris：9~20 parts, cassia seed：15~25 parts, pueraria lobata：7~18 parts, Radix Notoginseng：15~26 parts, garden burnet：
10~20 parts, cacumen biotae：10~22 parts, hairyvein agrimony：3~15 parts, 500 mesh or more are crushed to by micronizer after mixing
Particle；
Step 3, the particle obtained by step 2 is added water to cook and obtains decocting liquid three times, the liquid decocted three times is merged
After be filtered, extract filtrate after filtering, the relative density that filtrate to 65 DEG C~90 DEG C is concentrated under reduced pressure is 1.15~1.31, is obtained
Concentrate；
Step 4, into the concentrate obtained by step 3, oral solution, capsule, tablet or granule is made in addition auxiliary material.
The features of the present invention also characterized in that
In three amicron decoction processes of the step 3,8~10 times that amount of water is medicinal material amount are decocted for the first time, decoct 2
~4 hours, it was 4~8 times of medicinal material amount that second, which decocts amount of water, is decocted 2~3 hours, and it is medicinal material that third time, which decocts amount of water,
2~4 times of amount decoct 1~2 hour.
Auxiliary material in step 4 is sucrose, starch, methylcellulose, carboxymethyl cellulose sodium, magnesium stearate, superfine silica gel powder, ten
One or more kinds of combinations in sodium dialkyl sulfate, hydroxypropyl methyl cellulose, talcum powder.
The invention has the advantages that antitumor Chinese provided by the invention have soothing liver-qi stagnation, it is promoting blood circulation and removing obstruction in channels,
Toxin-expelling intestine-cleaning, astringing to arrest bleeding the effect of, using rhizoma cyperi, fingered citron, radix tetrastigme, lance asiabell root, corydalis tuber as monarch drug in a prescription, play qi-regulating solution
Strongly fragrant, The flat liver of heat-clearing effect plays promoting blood circulation and removing blood stasis, wind-dispelling and lives using Radix Salviae Miltiorrhizae, ginkgo leaf, myrrh, herba aristolochiae, Fructus Liquidambaris as ministerial drug
The effect of network, using cassia seed, pueraria lobata, garden burnet as adjutant, play relax bowel, clearing heat and detoxicating effect, with Radix Notoginseng, cacumen biotae,
Hairyvein agrimony is to make medicine, plays the role of astringing to arrest bleeding, detumescence ding-tong, and all medicines share collaboration works, while soothing liver-qi stagnation, also
Can be promoting blood circulation and removing obstruction in channels, it is notable for the therapeutic effect of tumour, and the Chinese medicine composition of the present invention has drawn from Chinese herbal medicine, it is nontoxic secondary to make
With good patient compliance, medical expense is low, easy to use, and mouth is made in the formulation method that the Chinese medicine composition can be routinely
Liquid, capsule, tablet or granule are taken, is improved using popularity.
Specific implementation mode
The present invention is described in detail With reference to embodiment.
A kind of antitumor Chinese of the present invention, includes each component of following masses number：Rhizoma cyperi：20~30 parts, three
Ye Qing：10~30 parts, lance asiabell root：10~25 parts, corydalis tuber：5~15 parts, Radix Salviae Miltiorrhizae：8~16 parts, fingered citron：20~30 parts, ginkgo
Leaf：15~30 parts, myrrh：10~20 parts, herba aristolochiae：5~12 parts, Fructus Liquidambaris：9~20 parts, cassia seed：15~25 parts, pueraria lobata：
7~18 parts, Radix Notoginseng：15~26 parts, garden burnet：10~20 parts, cacumen biotae：10~22 parts, hairyvein agrimony：3~15 parts.
The preparation method of above-mentioned antitumor Chinese, specifically implements according to the following steps：
Step 1, rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Lu Lu are taken
Logical, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2, rhizoma cyperi is weighed respectively according to mass fraction：20~30 parts, radix tetrastigme：10~30 parts, lance asiabell root：10~25
Part, corydalis tuber：5~15 parts, Radix Salviae Miltiorrhizae：8~16 parts, fingered citron：20~30 parts, ginkgo leaf：15~30 parts, myrrh：10~20 parts, day
Celestial rattan：5~12 parts, Fructus Liquidambaris：9~20 parts, cassia seed：15~25 parts, pueraria lobata：7~18 parts, Radix Notoginseng：15~26 parts, garden burnet：
10~20 parts, cacumen biotae：10~22 parts, hairyvein agrimony：3~15 parts, 500 mesh or more are crushed to by micronizer after mixing
Particle；
Step 3, the particle obtained by step 2 is added water to cook and obtains decocting liquid three times, the liquid decocted three times is merged
After be filtered, extract filtrate after filtering, the relative density that filtrate to 65 DEG C~90 DEG C is concentrated under reduced pressure is 1.15~1.31, is obtained
Concentrate；
Step 4, into the concentrate obtained by step 3, oral solution, capsule, tablet or granule is made in addition auxiliary material.
The function of each raw material component is as follows：
Rhizoma cyperi：It is sweet in flavor, mild-natured, Return liver, tri-jiao channel；With regulating the flow of vital energy Xie Yu, menstruction regulating and pain relieving and other effects, for treating liver depression gas
It is stagnant, chest, the side of body, abdominal distention, indigestion, irregular menstruation, closed dysmenorrhea, cold hernia stomachache, the diseases such as swollen breasts.
Fingered citron：With soothing liver-qi stagnation, qi-regulating is in, eliminating dampness and eliminating phlegm, hypoglycemic, blood pressure and other effects, for treating liver depression gas
Stagnant distending pain in the chest and hypochondrium, liver-stomach disharmony, the taste stagnation of the circulation of vital energy, the illnesss such as evil of vomitting deficiency of food.
Radix tetrastigme：It is sweet in flavor, it is cool in nature, there are the work(such as clearing heat and detoxicating, blood circulation promoting and dispersing pathogen accumulation, anti-inflammatory analgetic, dispelling pathogenic wind and eliminating phlegm, regulating qi-flowing for strengthening spleen
Effect, for treating high fever, tonsillitis, bronchitis, pneumonia, sphagitis, hepatitis, gastritis, cervicitis, scrofula, losing
The diseases such as mass formed by blood stasis and viral meningitis.Modern medical studies have confirmed that Lemna paucicostata can also effectively inhibit tumor cell proliferation,
Promote apoptosis of tumor cells.
Lance asiabell root：It is sweet in flavor, mild-natured, return lung, liver, spleen, large intestine channel；With work(such as internal heat anticance, benefiting qi and nourishing blood, detumescence and apocenosis
Effect, for controlling lung carbuncle, acute appendicitis, pyogenic infections, scrofula, the diseases such as tonsillitis.
Corydalis tuber：Bitter, warm-natured, the thoughts of returning home, liver, the spleen channel；With promoting blood circulation, promoting the circulation of qi, analgesic and other effects, for treating pain of gastric cavity
Bitterly, heat symptom-complex stomachache, sympotoms caused by cold factors stomachache, energy-stagnation stomachache, extravasated blood stomachache, middle empty stomachache, the pain in chest and hypochondrium of stagnation of QI due to depression of the liver, liver depression forming fire it
The diseases such as pain in chest and hypochondrium, cold hernia stomachache, arthralgia pain due to rheumatism, qi depression to blood stasis, traumatic injury, pain caused by ecchymoma.
Radix Salviae Miltiorrhizae：Bitter, cold nature, converge to heart and liver channels；With promoting blood circulation scattered silt, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, expansion
Coronary artery is opened, improves myocardial ischemia situation, reduce blood pressure, with all worries set aside, hypoglycemic and antibacterial and other effects of calming the nerves, for treating the obstruction of qi in the chest
It is pained, gastral cavity abdomen hypochondriac pain, hot numbness heat pain, dysphoria and insomnia, in addition, modern medicine it is demonstrated experimentally that Radix Salviae Miltiorrhizae also have anti-platelet aggregation,
It reduces blood viscosity and adjusts the function of inside and outside blood coagulation system.
Ginkgo leaf：It is sweet in flavor, bitter, puckery, mild-natured, distributed in heart and lung channels；It with astringing the lung, relievings asthma, promoting blood circulation and removing blood stasis, analgesic and other effects is used
In treatment hypertension, artery sclerosis, aorto-arteritis, obliterans, angina pectoris, myocardial infarction, cerebral embolism, aplastic
The diseases such as anaemia.
Myrrh：Bitter, mild-natured, Return liver, spleen, the heart, kidney channel；With scattered blood stasis eliminatings, detumescence ding-tong and other effects falls for treating
Beat the diseases such as damage, metal-inflicted wound, muscles and bones, all pains of trusted subordinate, abdominal mass, Amenorrhea, ulcer sore pain, anal fistula, mesh barrier.
Herba aristolochiae：Bitter, warm-natured, Return liver, spleen, kidney channel；With the promoting flow of qi and blood circulation, inducing diuresis for removing edema and other effects, for controlling
Stomachache, hernia pain, cyesedema, postpartum vim and vigour abdominal pain, the diseases such as rheumatalgia pain.
Fructus Liquidambaris：Bitter, it is mild-natured, return liver and kidney channel；With dispelling, collateral-activating, Li Shui stimulates the menstrual flow and other effects, for treating joint numbness
Bitterly, numbness contracture, oedema turgor, the diseases such as few Amenorrhea of breast.
Cassia seed：Bitter, cold nature, Return liver, large intestine channel；With heat-clearing improving eyesight, relax bowel and other effects, for treating mesh
Red puckery pain, the more tears of photophobia, dizziness of having a headache, mesh is secretly unknown, constipation, the diseases such as hypertension.
Pueraria lobata：It is sweet in flavor, it is cool in nature, have the function of that heat-clearing, fall fire, toxin expelling, reinforcing liver and gall cell autoimmunity, resistance virus enter
It invades, slow down aging, adjust the effect of blood-fat and blood sugar, for treating myocardial ischemia and cerebral ischemic condition, prevention and treatment of coronary heart disease, the heart twist
Bitterly, the cranial vascular diseases such as myocardial infarction, cerebral infarction, hemiplegia, vascular dementia.
Garden burnet：Bitter, cold in nature, Return liver, lung, kidney and large intestine channel；It is clearing heat and detoxicating with cooling blood and hemostasis, clear yin-nourishing is trained, is subsided a swelling
Sore and other effects, for treat haematemesis, bloody flux, burn wound, eczema, upper gastrointestinal bleeding, canker massive haemorrhage, have blood in stool, uterine bleeding,
The diseases such as Tuberculous purulence ulcer and chronic osteomyelitis.
Radix Notoginseng：Sweet in flavor, slight bitter, warm-natured, Return liver, stomach；With dissipate stasis of blood hemostasis, the effect of detumescence ding-tong, coughed up for treating
Blood is spitted blood, and bleeding from five sense organs or subcutaneous tissue is had blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen shouting pain, the diseases such as tumbling and swelling.
Cacumen biotae：Bitter, cold in nature, return lung, liver, the spleen channel；With cooling blood and hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair and other effects is used
It spits blood in treatment, bleeding from five sense organs or subcutaneous tissue, spitting of blood is had blood in stool, metrostaxis, cough with lung heat, blood-head alopecia, the diseases such as poliosis.
Hairyvein agrimony：Bitter, it is warm-natured, there is astringing to arrest bleeding, stop dysentery, desinsection and other effects, be widely used in the various bleedings for the treatment of it
Card, such as：Haematemesis, hematuria, have blood in stool, uterine bleeding, spitting of blood, bleeding from five sense organs or subcutaneous tissue, dysentery, internal lesion caused by overexertion power off, carbuncle swells, bruise, traumatic bleeding etc.
Card.
Embodiment 1
A kind of antitumor Chinese includes each component of following masses part (every part of 100g)：
30 parts of rhizoma cyperi, 30 parts of radix tetrastigme, 10 parts of lance asiabell root, 8 parts of corydalis tuber, 8 parts of Radix Salviae Miltiorrhizae, 25 parts of fingered citron, 30 parts of ginkgo leaf,
14 parts of myrrh, 5 parts of herba aristolochiae, 20 parts of Fructus Liquidambaris, 20 parts of cassia seed, 13 parts of pueraria lobata, 25 parts of Radix Notoginseng, 15 parts of garden burnet, cacumen biotae 18
Part, 6 parts of hairyvein agrimony.
Preparation method is as follows：
Step 1, rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Lu Lu are taken
Logical, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2,30 parts of rhizoma cyperi, 30 parts of radix tetrastigme, 15 parts of lance asiabell root, 8 parts of corydalis tuber, pellet are weighed respectively according to mass fraction
8 parts of ginseng, 25 parts of fingered citron, 30 parts of ginkgo leaf, 14 parts of myrrh, 5 parts of herba aristolochiae, 20 parts of Fructus Liquidambaris, 20 parts of cassia seed, 13 parts of pueraria lobata,
25 parts of Radix Notoginseng, 15 parts of garden burnet, 18 parts of cacumen biotae, 6 parts of hairyvein agrimony are crushed to the particle of 550 mesh by micronizer after mixing；
Step 3, the particle obtained in step 2 is added water to cook obtain three times decoct liquid, first time amount of water be medicinal material
8 times of amount decoct 4 hours, and second of amount of water is 6 times of medicinal material amount, is decocted 3 hours, and third time amount of water is the 4 of medicinal material amount
Times, it decocts 2 hours, is then combined with each decoction liquid and filters, filtrate is extracted after filtering, the phase at filtrate to 85 DEG C is concentrated under reduced pressure
It is 1.31 to density, obtains concentrate；
Step 4, adaptable (auxiliary material) sucrose, methylcellulose, stearic acid are added in the concentrate obtained into step 3
Magnesium, talcum powder are according to mass ratio 343:15:3:1.5:4 uniformly mixed starch, superfine silica gel powder, lauryl sodium sulfate, hydroxypropyl
Methylcellulose is uniformly mixed, and granulation, is filled into capsule shells drying, and capsule is made.
Embodiment 2
A kind of antitumor Chinese includes each component of following masses part (every part of 100g)：
25 parts of rhizoma cyperi, 12 parts of radix tetrastigme, 20 parts of lance asiabell root, 13 parts of corydalis tuber, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of fingered citron, ginkgo leaf 15
Part, 12 parts of myrrh, 12 parts of herba aristolochiae, 14 parts of Fructus Liquidambaris, 15 parts of cassia seed, 15 parts of pueraria lobata, 18 parts of Radix Notoginseng, 10 parts of garden burnet, arbor-vitae
10 parts of leaf, 15 parts of hairyvein agrimony.
Preparation method is as follows：
Step 1, rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Lu Lu are taken
Logical, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2,25 parts of rhizoma cyperi is weighed respectively according to mass fraction, 12 parts of radix tetrastigme, 20 parts of lance asiabell root, 13 parts of corydalis tuber,
15 parts of Radix Salviae Miltiorrhizae, 20 parts of fingered citron, 15 parts of ginkgo leaf, 12 parts of myrrh, 12 parts of herba aristolochiae, 14 parts of Fructus Liquidambaris, 15 parts of cassia seed, pueraria lobata 15
Part, 18 parts of Radix Notoginseng, 10 parts of garden burnet, 10 parts of cacumen biotae, 15 parts of hairyvein agrimony are crushed to 600 purposes after mixing by micronizer
Particle；
The particle obtained in step 2 is added water to cook and obtains decocting liquid for 3 times by step 3, and first time amount of water is medicinal material amount
10 times, decoct 3 hours, second amount of water is 4 times of medicinal material amount, is decocted 2 hours, and third time amount of water is the 3 of medicinal material amount
Times, it decocts 1.5 hours, is then combined with each decoctions liquid and filters, extract filtrate after filtering, reduced pressure filtrate is at 80 DEG C
Relative density is 1.21, obtains concentrate；
Step 4, adaptable (auxiliary material) starch, methylcellulose, carboxymethyl are added in the concentrate obtained into step 3
Fiber sodium, magnesium stearate are according to mass ratio 343:10:2:4:1.5 are uniformly mixed, and tablet is made in granulation, dry, tabletting.
Embodiment 3
A kind of antitumor Chinese includes each component of following masses part (every part of 100g)：
20 parts of rhizoma cyperi, 10 parts of radix tetrastigme, 15 parts of lance asiabell root, 5 parts of corydalis tuber, 12 parts of Radix Salviae Miltiorrhizae, 30 parts of fingered citron, ginkgo leaf 17
Part, 20 parts of myrrh, 8 parts of herba aristolochiae, 9 parts of Fructus Liquidambaris, 25 parts of cassia seed, 18 parts of pueraria lobata, 15 parts of Radix Notoginseng, 14 parts of garden burnet, cacumen biotae
22 parts, 3 parts of hairyvein agrimony.
Preparation method is as follows：
Step 1, rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Lu Lu are taken
Logical, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2,20 parts of rhizoma cyperi, 10 parts of radix tetrastigme, 15 parts of lance asiabell root, 5 parts of corydalis tuber, pellet are weighed respectively according to mass fraction
12 parts of ginseng, 30 parts of fingered citron, 17 parts of ginkgo leaf, 20 parts of myrrh, 8 parts of herba aristolochiae, 9 parts of Fructus Liquidambaris, 25 parts of cassia seed, 18 parts of pueraria lobata,
15 parts of Radix Notoginseng, 14 parts of garden burnet, 22 parts of cacumen biotae, 3 parts of hairyvein agrimony are crushed to the particle of 700 mesh by micronizer after mixing；
Step 3, the particle obtained in step 2 is added water to cook and obtains decocting liquid three times, first time amount of water is medicinal material
8 times of amount decoct 2 hours, and second of amount of water is 8 times of medicinal material amount, is decocted 3 hours, and third time amount of water is the 2 of medicinal material amount
Times, it decocts 1 hour, is then combined with each decoction liquid and filters, filtrate is extracted after filtering, the phase at filtrate to 65 DEG C is concentrated under reduced pressure
It is 1.15 to density, obtains concentrate；
Step 4, adaptable (auxiliary material) starch, superfine silica gel powder, dodecyl sulphur are added in the concentrate obtained into S3
Sour sodium, hydroxypropyl methyl cellulose are according to mass ratio 343:10:3:4:2 are uniformly mixed, and granulation, dry, arrangement classification will be made
Particle directly pack, granule is made.
Embodiment 4
A kind of antitumor Chinese includes each component of following masses part (every part of 100g)：
21 parts of rhizoma cyperi, 12 parts of radix tetrastigme, 25 parts of lance asiabell root, 15 parts of corydalis tuber, 16 parts of Radix Salviae Miltiorrhizae, 23 parts of fingered citron, ginkgo leaf 15
Part, 10 parts of myrrh, 12 parts of herba aristolochiae, 10 parts of Fructus Liquidambaris, 15 parts of cassia seed, 7 parts of pueraria lobata, 26 parts of Radix Notoginseng, 20 parts of garden burnet, cacumen biotae
12 parts, 9 parts of hairyvein agrimony.
Preparation method is as follows：
Step 1, rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Lu Lu are taken
Logical, cassia seed, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2,21 parts of rhizoma cyperi is weighed respectively according to mass fraction, 12 parts of radix tetrastigme, 25 parts of lance asiabell root, 15 parts of corydalis tuber,
16 parts of Radix Salviae Miltiorrhizae, 23 parts of fingered citron, 15 parts of ginkgo leaf, 10 parts of myrrh, 12 parts of herba aristolochiae, 10 parts of Fructus Liquidambaris, 15 parts of cassia seed, pueraria lobata 7
Part, 26 parts of Radix Notoginseng, 20 parts of garden burnet, 12 parts of cacumen biotae, it is micro- by micronizer to be crushed to 750 purposes 9 parts of hairyvein agrimony after mixing
Grain；
Step 3, the particle obtained in step 2 is added water to cook and obtains decocting liquid three times, first time amount of water is medicinal material
9 times of amount decoct 4 hours, and second of amount of water is 7 times of medicinal material amount, is decocted 2.5 hours, and third time amount of water is medicinal material amount
4 times, decoct 1 hour, be then combined with each decoctions liquid and filter, extract filtrate after filtering, reduced pressure filtrate is at 90 DEG C
Relative density be 1.23, obtain concentrate；
Step 4, adaptable (auxiliary material) sucrose, carboxymethyl cellulose sodium, talcum are added in the concentrate obtained into step 3
Powder is according to mass ratio 343:15:2:2 are uniformly mixed, and add suitable quantity of water to 1000ml, oral solution is made.
Examples 1 to 4 has prepared the antitumor Chinese to work well, is prepared due to Examples 1 to 4
Antitumor Chinese effect is substantially parallel, therefore comes to this only with the antitumor Chinese that embodiment 1 is prepared
The effect of invention illustrates.
Further the effect of the present invention is illustrated using animal experiment and clinical test below.
One, animal experiment
1, acute toxicity testing
Using NIH mouse 60, SPF grades, half male and half female, weight 18-22g carries out acute toxicity test.Mouse is divided at random
It is four groups, every group 15, i.e. A groups：Blank control group；B groups：Chinese medicine composition small dose group of the present invention；C groups：Chinese medicine of the present invention
Composition middle dose group；D groups：Chinese medicine composition large dosage group of the present invention；Fasting 12 hours before experiment；By the embodiment of the present invention
The 1 anti-tumor Chinese medicine granule prepared is dissolved in water, and every milliliter of liquid 0.5g containing raw medicinal herbs (small dose group), 3.5g is made
(middle dose group), the liquid of 6g (large dosage of group) is primary to the daily gastric infusion of mouse after grouping, and A groups fill physiological saline
30mL/kg, B group fill Chinese medicine composition low dose liquid 30mL/kg, C group of the present invention and fill Chinese medicine composition middle dosage medicine of the present invention
Liquid 30mL/kg, D group fills Chinese medicine composition large dosage liquid 30mL/kg of the present invention, and continuous fill is raised one month respectively, and is recorded small
The toxic reaction and death toll of mouse.
The experimental results showed that：Compared with the control group, mouse has no that notable difference, experiment are observed continuously one month after administration,
Mouse systemic situation, diet, drinking-water, body weight increase are normal；The experiment of high, medium and low three dosage is observed by dissection animal tissue
For group compared with blank control group, animal tissue's form does not have notable difference.Therefore the Chinese medicine preparation acute toxicity of the present invention is low, faces
Bed drug safety.
2, long term toxicity test
Anti-tumor Chinese medicine granules of rats prepared by the embodiment of the present invention 1 presses 12g and 180g raw medicinal herbs/kg continuous uses
10 weeks (1.0mL/100g weight, 1 time a day) and drug withdrawal are observed mouse after 4 weeks, are detected.
The experimental results showed that：It is the hair of anti-tumor Chinese medicine granules of rats prepared by the embodiment of the present invention 1, behavior, big
The indexs such as urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes are not found
After abnormal variation and histological indications show medication 10 weeks and are discontinued 4 weeks, each internal organs of rat nothing is substantially change.Explanation
Small toxicity after anti-tumor Chinese medicine granules of rats long-term administration prepared by the embodiment of the present invention 1, also without abnormal anti-after drug withdrawal
It answers, application is safe.
Two, clinical trial
1, clinical case
The cancer patient made a definite diagnosis is development test object, chooses 45 clinical cases, wherein male 27, women 18,
It is eldest 69 years old, 40 years old minimum, clinical manifestation：Palpitaition weak, nausea and vomiting, is had blood in stool, body heat, abdomen distending pain.
2, therapy
The granule that the embodiment of the present invention 1 is prepared is taken during treatment, is respectively taken daily morning and evening once, once 2 bags, one
Bag 3g, treatment cycle are 10 weeks.
3, treatment effectiveness evaluation
It is effective：Tumour reduces, and immunity improves, energetic, painless；
Effectively：Tumour is substantially achieved inhibition, and immunity increases, and spirit is not good enough；Pain relief；
In vain：Tumour is reduction or even continued growth, and mental status is poor, still has pain, symptom apparent.
4, experimental result
Effective 30 in 45 patients, effective 13, invalid 2, total effective rate is up to 95.6%.
5, model case
Chinese medicine composition of the present invention has significant curative effect, case case as follows oncotherapy：
Example 1, XX, man, 50 years old, the beginning body heat in March, 2015, the soft inability of people was uncomfortable in chest, was lung through hospital diagnosis
Cancer, right lung pain, expiratory dyspnea are not hospitalized, and hospital opens Chinese medicine, and patient goes home to take after the several months without improvement, takes of the invention real
The capsule of example 1 is applied after one month, patient body gradually improves, and continues after taking 6 months, and recovery from illness is not recurred, and can descend ground
Dry farm work.
Example 2, XX, female, 45 years old, the first half of the year in 2016 was diagnosed as gastric cancer, and symptom is nauseous, weak, uncomfortable in chest, low-heat chilly,
Abdomen distending pain is not operated on and is performed an operation, and using conservative treatment, takes the capsule of the embodiment of the present invention 1 after one month, the state of an illness is good
Turn, symptom mitigates, and can arrive outdoor activity, continue to take 2 months, can take a walk daily to outside, can do housework work.
Example 3, XX, man 70 years old, are diagnosed as intestinal cancer in January, 2017, and symptom is palpitaition, weak, nausea and vomiting, has blood in stool, takes
The capsule of the embodiment of the present invention 1 is after one month, and sb.'s illness took a favorable turn, and each symptom is light and slow, continues to be almost recovered after taking half a year,
So far without recurrence.
To sum up, Chinese prescription of the present invention is reasonable, at low cost, drug convenient material drawing, preparation are simple, short treating period, treatment
Effect is notable, has no toxic side effect.
Claims (4)
1. a kind of antitumor Chinese, which is characterized in that include each component of following mass fraction：Rhizoma cyperi：20~30 parts,
Radix tetrastigme：10~30 parts, lance asiabell root：10~25 parts, corydalis tuber：5~15 parts, Radix Salviae Miltiorrhizae：8~16 parts, fingered citron：20~30 parts, silver
Apricot leaf：15~30 parts, myrrh：10~20 parts, herba aristolochiae：5~12 parts, Fructus Liquidambaris：9~20 parts, cassia seed：15~25 parts, Pueraria lobota
Root：7~18 parts, Radix Notoginseng：15~26 parts, garden burnet：10~20 parts, cacumen biotae：10~22 parts, hairyvein agrimony：3~15 parts.
2. a kind of preparation method of antitumor Chinese, which is characterized in that be specifically to implement according to the following steps：
Step 1, it takes rhizoma cyperi, radix tetrastigme, lance asiabell root, corydalis tuber, Radix Salviae Miltiorrhizae, fingered citron, ginkgo leaf, myrrh, herba aristolochiae, Fructus Liquidambaris, determine
Pine torch, pueraria lobata, Radix Notoginseng, garden burnet, cacumen biotae, hairyvein agrimony, clean, dry；
Step 2, rhizoma cyperi is weighed respectively according to mass fraction：20~30 parts, radix tetrastigme：10~30 parts, lance asiabell root：10~25 parts,
Corydalis tuber：5~15 parts, Radix Salviae Miltiorrhizae：8~16 parts, fingered citron：20~30 parts, ginkgo leaf：15~30 parts, myrrh：10~20 parts, beauty
Rattan：5~12 parts, Fructus Liquidambaris：9~20 parts, cassia seed：15~25 parts, pueraria lobata：7~18 parts, Radix Notoginseng：15~26 parts, garden burnet：10
~20 parts, cacumen biotae：10~22 parts, hairyvein agrimony：3~15 parts, the micro- of 500 mesh or more is crushed to by micronizer after mixing
Grain；
Step 3, the particle obtained by step 2 is added water to cook and obtains decocting liquid three times, the liquid decocted three times merged laggard
Row filtering, extracts filtrate after filtering, the relative density that filtrate to 65 DEG C~90 DEG C is concentrated under reduced pressure is 1.15~1.31, is concentrated
Liquid；
Step 4, into the concentrate obtained by step 3, oral solution, capsule, tablet or granule is made in addition auxiliary material.
3. the preparation method of the Chinese medicine composition for the treatment of digestive tract ulcer according to claim 2, which is characterized in that described
In three amicron decoction processes of step 3, it is 8~10 times of medicinal material amount to decoct amount of water for the first time, decoction 2~4 hours, second
The secondary amount of water that decocts is 4~8 times of medicinal material amount, is decocted 2~3 hours, third time decocts 2~4 times that amount of water is medicinal material amount, pan-fried
It boils 1~2 hour.
4. the preparation method of the Chinese medicine composition for the treatment of digestive tract ulcer according to claim 2, which is characterized in that described
Auxiliary material in step 4 is sucrose, starch, methylcellulose, carboxymethyl cellulose sodium, magnesium stearate, superfine silica gel powder, dodecyl sulphur
One or more kinds of combinations in sour sodium, hydroxypropyl methyl cellulose, talcum powder.
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| CN112168684A (en) * | 2020-10-28 | 2021-01-05 | 王秀琴 | Moxa cone for treating cyst, nodule, hyperplasia and tumor and preparation method thereof |
| CN113274447A (en) * | 2021-06-10 | 2021-08-20 | 衢州市王德裕堂国药有限公司 | Anti-tumor traditional Chinese medicine composition |
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Application publication date: 20181009 |