CN105770691A - Medicinal preparation for treating cervical cancer and application thereof - Google Patents

Medicinal preparation for treating cervical cancer and application thereof Download PDF

Info

Publication number
CN105770691A
CN105770691A CN201610141673.8A CN201610141673A CN105770691A CN 105770691 A CN105770691 A CN 105770691A CN 201610141673 A CN201610141673 A CN 201610141673A CN 105770691 A CN105770691 A CN 105770691A
Authority
CN
China
Prior art keywords
parts
herba
semen
pharmaceutical preparation
grams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610141673.8A
Other languages
Chinese (zh)
Inventor
陈红
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610141673.8A priority Critical patent/CN105770691A/en
Publication of CN105770691A publication Critical patent/CN105770691A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/68—Plantaginaceae (Plantain Family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/746—Morinda
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention relates to a medicinal preparation for treating cervical cancer and application thereof. The medicinal preparation contains hypericum perforatum, caulis sinomenii, okra, cowherb seeds, green tangerine peel, dandelion, plantain herb, chingma abutilon seeds, flatstem milkvetch seeds, mock-strawberries, red halloysite, fructus amomi, selfheal, diversifolious patrinia root, honeysuckle stem, liquorice root, folium artemisiae argyi, serissa japonica, Chinese pyrola herb, calamint, hedera helix, common bombax flower, Chinese birch, fructus forsythia, portulaca oleracea, mulberries, radish seeds and pepperweed seeds. According to the medicinal preparation for treating the cervical cancer, traditional Chinese medicinal materials with different medicinal properties are adopted to cooperate with one another scientifically; the medicinal preparation is a traditional Chinese medicinal preparation, but the traditional Chinese medicines with peaceful flavour are finely selected, so that the flavour of the traditional Chinese medicinal preparation is not thick; the compliance of a patient is high; clinical experiments show that the medicinal preparation used for treating the cervical cancer provided by the invention can effectively inhibit the development of the cervical cancer, improve symptoms of the patient, and inhibit, kill and reduce a tumour, so that the cure rate of the cervical cancer is greatly improved; moreover, the medicinal preparation has no obvious toxic or side effect.

Description

A kind of for pharmaceutical preparation treating cervical cancer and application thereof
Technical field
The present invention relates to for medicine treating cancer and application thereof, particularly to a kind of pharmaceutical preparation for treating cervical cancer and purposes, belong to field of medicaments.
Background technology
The change lived along with people and the cataclysm of environment, the continuous adjustment of diet structure, digestive system disease constantly rises, being continuously increased of various alimentary tract cancers, and cervical cancer, as the representative of digestive disease system, has the trend of annual increase.
Cervical cancer (cervicalcancer, CC) is one of modal malignant tumor of women, is only second to breast carcinoma and occupy second.The whole world there are about 500,000 people every year and is diagnosed as cervical cancer, just had every two minutes a women dead because of cervical cancer, there are about 300,000 people every year and therefore die.China has 130,000 newly to send out cases of cervical cancer every year, there are about 30,000 women and dies from cervical cancer.
Cervical cancer refers to cervical epithelial cell generation canceration, and disease penetrates basement membrane infiltration stroma, is the modal pernicious Genital neoplasms of whole world women.Cervical cancer pathogenesis reason great majority are relevant with patient's daily life, and such as viral infection, sexual behaviour and parturition number, other biological factor, other behavial factors are likely to increase prevalence.Cervical cancer symptom is mostly colporrhagia, and early stage mostly is contact bleeding, and middle and advanced stage is irregular colporrhagia, menostaxis, menorrhagia；The irregular colporrhagia of post menopausal, the patient in all ages and classes stage, Symptoms also can be different.Cervical cancer symptom is except vaginal hemorrhage, and most of patients there will be neoplasm (liquid is white or courageous and upright, can be thin such as water sample or water from washing rice shape, or has stench).Late period, symptom there will be different Secondary Symptoms.As frequent micturition, urgent micturition, constipation, lower limb swell and ache.
Therapeutic Method about cervical cancer has operative treatment, radiotherapy and chemotherapy at present, and operative treatment is generally adopted radical hysterectomy and pelvic lymph node eliminates.Excision extension includes standby group lymph node in full uterus, bilateral adnexa, vagina epimere and paracolpium and pelvic cavity (by cervix uteri, in closed pore, ilium, ilium is outer, the total hypomere lymph node of ilium), and operation requires thoroughly, safety, strictly grasp indication, prevent complication.But as easy as rolling off a log cause that women is sterile throughout one's life, bring certain obstacle to father's emotional lives；The treatment of a certain cervical cancer is had obvious action by radiotherapy, uses and is subject to certain limitation, and the effective percentage of chemotherapy is less than 15%, and patients with terminal can adopt the Comprehensive Treatment such as chemotherapy, radiotherapy.Chemotherapeutics can adopt 5-fluorouracil, and amycin etc. carries out vein or local injection.
Summary of the invention
For the defect of prior art, the present invention be directed to the present situation for the treatment of at present, it is provided that a kind of for pharmaceutical preparation treating cervical cancer and application thereof, toxic and side effects is little, effective.
Specifically, the concrete scheme of the present invention is achieved in that
First, inventor provides a kind of pharmaceutical preparation for treating cervical cancer according to drug matching experience, and the Chinese medicine ingredients contained in prescription is: Herba Hyperici Monogyni, Caulis Sinomenii, Flos abelmoschi manihot, Semen Vaccariae, Pericarpium Citri Reticulatae Viride, Herba Taraxaci, Herba Plantaginis, Semen Abutili, Semen Astragali Complanati, Herba Duchesneae Indicae, Halloysitum Rubrum, Fructus Amomi, Spica Prunellae, Radix Patriniae heterophyllae, Caulis Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi, Serissa foetida, Herba Pyrolae, Herba Clinopodii Polycephali, Caulis Hederae Sinensis, Flos Bombacis Malabarici, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Fructus Forsythiae, Herba portulacae, Fructus Mori, Semen Raphani, Semen Lepidii (Semen Descurainiae).
nullFurther，Inventor provides a kind of pharmaceutical preparation for treating cervical cancer according to drug matching experience，Each raw material dosage of prescription all has good curative effect in the weight portion scope of the present invention，Described formula and weight portion be: Herba Hyperici Monogyni 5-10 part、Caulis Sinomenii 3-8 part、Flos abelmoschi manihot 5-14 part、Semen Vaccariae 1-4 part、Pericarpium Citri Reticulatae Viride 2-8 part、Herba Taraxaci 10-16 part、Herba Plantaginis 6-14 part、Semen Abutili 3-7 part、Semen Astragali Complanati 1-4 part、Herba Duchesneae Indicae 2-7 part、Halloysitum Rubrum 3-8 part、Fructus Amomi 2-7 part、Spica Prunellae 9-17 part、Radix Patriniae heterophyllae 3-6 part、Caulis Lonicerae 2-8 part、Radix Glycyrrhizae 3-9 part、Folium Artemisiae Argyi 1-5 part、Serissa foetida 3-10 part、Herba Pyrolae 2-8 part、Herba Clinopodii Polycephali 1-5 part、Caulis Hederae Sinensis 3-7 part、Flos Bombacis Malabarici 1-6 part、Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 2-7 part、Fructus Forsythiae 10-18 part、Herba portulacae 10-20 part、Fructus Mori 12-7 part、Semen Raphani 2-5 part、Semen Lepidii (Semen Descurainiae) 2-6 part.
Further, the formula of above-mentioned weight portion is carried out preferably, reach superior technique effect, preferred formula is: Herba Hyperici Monogyni 7.5 parts, Caulis Sinomenii 5.5 parts, Flos abelmoschi manihot 10 parts, Semen Vaccariae 3 parts, 5 parts of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 13 parts, Herba Plantaginis 10 parts, Semen Abutili 5 parts, Semen Astragali Complanati 3 parts, Herba Duchesneae Indicae 4.5 parts, Halloysitum Rubrum 5.5 parts, Fructus Amomi 4 parts, Spica Prunellae 12 parts, Radix Patriniae heterophyllae 4 parts, Caulis Lonicerae 5 parts, 6 parts of Radix Glycyrrhizae, Folium Artemisiae Argyi 3 parts, Serissa foetida 6.5 parts, Herba Pyrolae 5 parts, Herba Clinopodii Polycephali 3 parts, Caulis Hederae Sinensis 5 parts, Flos Bombacis Malabarici 3.5 parts, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 4.5 parts, Fructus Forsythiae 14 parts, Herba portulacae 15 parts, Fructus Mori 9.5 parts, Semen Raphani 3.5 parts, Semen Lepidii (Semen Descurainiae) 4 parts.Or: Herba Hyperici Monogyni 8 parts, Caulis Sinomenii 6 parts, Flos abelmoschi manihot 11 parts, Semen Vaccariae 3.5 parts, 6 parts of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 14 parts, Herba Plantaginis 11 parts, Semen Abutili 5.5 parts, Semen Astragali Complanati 3.5 parts, Herba Duchesneae Indicae 5 parts, Halloysitum Rubrum 6 parts, Fructus Amomi 5 parts, Spica Prunellae 13 parts, Radix Patriniae heterophyllae 5 parts, Caulis Lonicerae 5.5 parts, 7 parts of Radix Glycyrrhizae, Folium Artemisiae Argyi 4 parts, Serissa foetida 7 parts, Herba Pyrolae 6 parts, Herba Clinopodii Polycephali 4 parts, Caulis Hederae Sinensis 6 parts, Flos Bombacis Malabarici 4 parts, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 5 parts, Fructus Forsythiae 15 parts, Herba portulacae 16 parts, Fructus Mori 10.5 parts, Semen Raphani 4 parts, Semen Lepidii (Semen Descurainiae) 4.5 parts.
In pharmaceutical preparation described above, the Chinese medicine used all uses its conventional medicinal part to be used as medicine, and the dosage of drug used is reasonable, and all medicines have, for treatment palace cancer, the effect treated preferably after share.
The function of each taste Chinese crude drug used in the pharmaceutical preparation of the treatment cervical cancer of the present invention is as follows:
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Folium Artemisiae Argyi: bitter in the mouth, warm in nature.
Gui Jing: return liver,spleen,kidney warp.
Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding, vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.
Herba Portulacae: sour in the mouth, cold in nature.
Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, for bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea；Furuncle swelling toxin, eczema, herpes zoster are controlled in external.
Radix Patriniae heterophyllae: bitter in the mouth, cool in nature.
Function cures mainly: heat clearing and damp drying, hemostasis, leukorrhagia stopping, preventing the attack (or recurrence) of malaria.
Caulis Lonicerae: sweet in the mouth, warm in nature.
Gui Jing: enter lung meridian.
Function cures mainly: heat-clearing and toxic substances removing, dispelling wind dredging collateral.Generate heat for epidemic febrile disease, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.
Serissa foetida: lightly seasoned, cool in nature.
Function cures mainly: dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.For catching a cold, cough, toothache, acute tonsillitis, pharyngolaryngitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, hypertension complicated headache, migraine, rheumatic arthralgia, leucorrhea；Stem ashing eye dripping controls mist.
Herba Pyrolae: sweet in the mouth, warm in nature.
Gui Jing: return liver, kidney channel.
Function cures mainly: wind-damp dispelling, bone and muscle strengthening, hemostasis.For rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Herba Clinopodii Polycephali: acrid in the mouth, cool in nature.
Function cures mainly: wind and heat dispersing, and detoxify dysentery relieving, hemostasis.For catching a cold, heatstroke, dysentery, hepatitis；Furuncle swelling toxin, skin pruritus, traumatic hemorrhage are controlled in external.
Caulis Hederae Sinensis: taste, property is put down
Gui Jing: return liver；Spleen；Lung meridian
Function cures mainly: dispel the wind；Dampness removing；Suppressing the hyperactive liver；Removing toxic substances.Main air pain of dampness syndrome；Paralysis；Mouth eye is oblique；Epistaxis；Menoxenia；Traumatic injury；Laryngopharynx swelling and pain；Furuncle furuncle carbuncle；Hepatitis；Snake bite and insect sting
Flos Bombacis Malabarici function cures mainly: heat clearing away, dampness removing, removing toxic substances, hemostasis.Controlling and have loose bowels, dysentery, metrorrhagia, sore, gold creates blood.
Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp.: bitter in the mouth；Cool
Function cures mainly: heat-clearing and toxic substances removing；Promoting blood circulation to remove blood stasis.Main cold, fever；Cough due to lung-heat；Gastroenteritis；Dysentery；Acute toothache；Swollen ulcer drug；Eczema；Traumatic injury；Traumatic hemorrhage
Fructus Forsythiae: bitter in the mouth, is slightly cold.
Gui Jing: return lung, the heart, small intestine meridian.
Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.
Spica Prunellae: acrid in the mouth, cold in nature.
Gui Jing: return liver, gallbladder meridian.
Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, dizziness of having a headache, scrofula, goiter, acute mastitis swells and ache；Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Herba Duchesneae Indicae: bitter in the mouth, cool in nature.
Function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, acute enteritis, bacillary dysentery, urinary system infection.
Halloysitum Rubrum: sweet in the mouth, warm in nature.
Gui Jing: return stomach, large intestine channel.
Function cures mainly: astringing intestine to stop diarrhea, and hemostasis, promoting tissue regeneration and ulcer healing, for chronic diarrhea chronic dysentery, fecal blood, bleeding not during menses.
Fructus Amomi: acrid in the mouth, warm in nature.
Gui Jing: return spleen, stomach, kidney channel.
Function cures mainly: removing dampness is whetted the appetite, and warming spleen and stopping diarrha, for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels.
Semen Astragali Complanati: sweet in the mouth, warm in nature.
Gui Jing: return liver, kidney channel.
Function cures mainly: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, premature ejaculation of passing out semen, nebulousurine leukorrhagia, dribbling urination, dizziness blurred vision.
Semen Abutili: bitter in the mouth, property is put down.
Gui Jing: return large intestine, small intestinal, bladder warp.
Function cures mainly: clearing away heat-damp and promoting diuresis, and detoxify nebula removing.For dysentery, the puckery pain of gonorrhea.
Herba Plantaginis: sweet in the mouth, cold in nature.
Gui Jing: return liver, kidney, lung, small intestine meridian.
Function cures mainly: clearing away heat and promoting diuresis, eliminates the phlegm, removing heat from blood, removing toxic substances, for edema oliguria, and the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, carbuncle sore tumefacting virus.
Herba Taraxaci: bitter in the mouth, cold in nature.
Gui Jing: return liver, stomach warp.
Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, for furuncle swelling toxin, acute mastitis scrofula, conjunctival congestion pharyngalgia, lung, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
Semen Vaccariae: bitter in the mouth, property is put down.
Gui Jing: return liver, stomach warp.
Function cures mainly: promoting blood circulation to restore menstrual flow, and stimulating milk secretion is subsided a swelling.For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache
Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, temperature.
Gui Jing: return liver, gallbladder, stomach warp.
Function cures mainly: soothing the liver dispelling the stagnated QI, removing food stagnancyization is stagnant.For distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, abdominal pain due to retention of food.
Flos abelmoschi manihot: lightly seasoned, cold in nature.
Gui Jing: enter kidney, stomach, bladder warp.
Function cures mainly: sore-throat relieving；Treating stranguria；Stimulating milk secretion regulating menstruation, main laryngopharynx swelling and pain；Urine leaching is puckery, and puerperal, milk was rare, menoxenia.
Caulis Sinomenii: bitter in the mouth, property is pungent
Gui Jing: return liver, spleen channel
Function: wind-damp dispelling, the meridian dredging, diuresis.
Herba Hyperici Monogyni: acrid in the mouth, cold in nature.
Gui Jing: return Liver Channel.
Effect: dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, lactogenesis of subsiding a swelling.
Semen Raphani: acrid in the mouth, property is put down.
Gui Jing: return lung, spleen, stomach warp.
Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Semen Lepidii (Semen Descurainiae): acrid in the mouth, cold in nature.
Gui Jing: return lung, bladder warp.
Function cures mainly: eliminating pathogen from the lung for relieving asthma, line water detumescence.Stop up lung, dyspnea and cough with excessive sputum, fullness and distention in the chest and hypochondrium for sputum, must not put down sleeping, chest and abdomen edema, dysuria；Pulmonary heart disease edema.
Fructus Mori: sweet in the mouth, cold in nature.
Gui Jing: GUIXIN, liver, kidney channel.
Function cures mainly: YIN nourishing of enriching blood, and promotes the production of body fluid and moisturizes.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.
Herba portulacae: sour in the mouth, cold in nature.
Function cures mainly: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea；Furuncle swelling toxin, eczema, herpes zoster are controlled in external.
The pharmaceutical dosage form of the present invention one in granule, capsule, tablet, injection, tincture, suppository, pill, syrup, mixture, powder, lotion, membrane, drop pill.More preferably capsule.
Above prescription through conscientious research, the reasonability according to middle medical drugs, the preparation method inventors herein proposing concrete a kind of pharmaceutical preparation treating cervical cancer, is concretely comprised the following steps by the present invention:
(1) take Folium Artemisiae Argyi, Radix Patriniae heterophyllae, Fructus Forsythiae, Fructus Mori, Herba Pyrolae, Herba Clinopodii Polycephali, Serissa foetida, Halloysitum Rubrum, Flos Bombacis Malabarici, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Flos abelmoschi manihot, Herba Taraxaci, Herba Plantaginis, Spica Prunellae and Herba portulacae and soak 1.5-3.0 hour, the boiled 10-20min of intense fire, slow fire 1.5-2.5 hour, decoct twice, merge twice filtrate, being evaporated to 90 DEG C, density is the extractum of 1.10, standby；
(2) take Caulis Lonicerae, Caulis Hederae Sinensis, Herba Hyperici Monogyni, Caulis Sinomenii, Pericarpium Citri Reticulatae Viride, Semen Abutili and Fructus Amomi to grind to form coarse powder and add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, stand 24 hours, standby；
(3) extracting liquorice, Semen Raphani, Semen Lepidii (Semen Descurainiae), Semen Vaccariae, Semen Astragali Complanati and Herba Duchesneae Indicae are ground into appropriate 70% ethanol extraction of fine powder 2 times, each 1.5 hours, collect extracting solution, merge medicinal liquid, stand 24 hours, standby；
(4) taking the supernatant prepared in (2nd) and (3) step, decompression recycling ethanol, be concentrated into 70 DEG C, density is the extractum of 1.03, standby；
(5) the extractum mix homogeneously of step (1) and (4) is obtained mixture, prepare into pharmaceutical preparation with pharmaceutically acceptable adjuvant.
Pharmaceutical preparation in above-mentioned preparation method, granule, powder, capsule, pill, tablet and clinically acceptable dosage form are prepared in described pharmaceutical preparation.Wherein the preparation of capsule is the mixture adding the lactose of step (5) mixture weight 10% and dextrin, in the mixture of lactose and dextrin lactose and and the weight ratio of dextrin be 1:1；Stir heating to 75 DEG C, dry, add binding agent and cross 16 mesh sieves, granulate, dry and load capsule, obtaining capsule, capsule weight 200mg.
Compared with prior art, the present invention treats having the advantage that of cervical cancer
The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, although the present invention is Chinese medicine preparation, but the Chinese medicine that selected abnormal smells from the patient is gentle, making the abnormal smells from the patient of Chinese medicine preparation and light, the compliance of patient is higher, and the present invention is for treating the medicine of cervical cancer, through clinical trial, show that it can effectively suppress cervical cancer to develop, improve patients symptomatic, it is suppressed that, kill, reduce tumor, the cure rate making cervical cancer is greatly improved, and without obvious toxic-side effects.
Specific embodiment
It is obvious to a person skilled in the art that the details of the embodiment of the present invention, and when without departing substantially from the spirit of the present invention or basic feature, it is possible to realize the present invention in other specific forms.Embodiment all should be regarded as exemplary, and be nonrestrictive, it is intended that all changes in the implication of the equivalency dropping on claim and scope are included in the present invention.
Embodiment 1: a kind of pharmaceutical preparation for treating cervical cancer, containing the Chinese crude drug of following weight portion:
Herba Hyperici Monogyni 5 grams, Caulis Sinomenii 3 grams, Flos abelmoschi manihot 5 grams, Semen Vaccariae 1 gram, 2 grams of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 10 grams, Herba Plantaginis 6 grams, Semen Abutili 3 grams, Semen Astragali Complanati 1 gram, Herba Duchesneae Indicae 2 grams, Halloysitum Rubrum 3 grams, Fructus Amomi 2 grams, Spica Prunellae 9 grams, Radix Patriniae heterophyllae 3 grams, Caulis Lonicerae 2 grams, 3 grams of Radix Glycyrrhizae, Folium Artemisiae Argyi 1 gram, Serissa foetida 3 grams, Herba Pyrolae 2 grams, Herba Clinopodii Polycephali 1 gram, Caulis Hederae Sinensis 3 grams, Flos Bombacis Malabarici 1 gram, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 2 grams, Fructus Forsythiae 10 grams, Herba portulacae 10 grams, Fructus Mori 12 grams, Semen Raphani 2 grams, Semen Lepidii (Semen Descurainiae) 2 grams.
Concrete preparation method is:
(1) take Folium Artemisiae Argyi, Radix Patriniae heterophyllae, Fructus Forsythiae, Fructus Mori, Herba Pyrolae, Herba Clinopodii Polycephali, Serissa foetida, Halloysitum Rubrum, Flos Bombacis Malabarici, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Flos abelmoschi manihot, Herba Taraxaci, Herba Plantaginis, Spica Prunellae and Herba portulacae and soak 1.5-3.0 hour, the boiled 10-20min of intense fire, slow fire 1.5-2.5 hour, decoct twice, merge twice filtrate, being evaporated to 90 DEG C, density is the extractum of 1.10, standby；
(2) take Caulis Lonicerae, Caulis Hederae Sinensis, Herba Hyperici Monogyni, Caulis Sinomenii, Pericarpium Citri Reticulatae Viride, Semen Abutili and Fructus Amomi to grind to form coarse powder and add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, stand 24 hours, standby；
(3) extracting liquorice, Semen Raphani, Semen Lepidii (Semen Descurainiae), Semen Vaccariae, Semen Astragali Complanati and Herba Duchesneae Indicae are ground into appropriate 70% ethanol extraction of fine powder 2 times, each 1.5 hours, collect extracting solution, merge medicinal liquid, stand 24 hours, standby；
(4) taking the supernatant prepared in (2nd) and (3) step, decompression recycling ethanol, be concentrated into 70 DEG C, density is the extractum of 1.03, standby；
(5) the extractum mix homogeneously of step (1) and (4) is obtained mixture, claim its weight, and add the mixture (lactose and and the weight ratio of dextrin be 1:1) of the lactose of its weight 10% and dextrin；Stir heating to 75 DEG C, dry, add binding agent and cross 16 mesh sieves, granulate, dry and load capsule, obtaining capsule, capsule weight 200mg.
Embodiment 2: a kind of pharmaceutical preparation for treating cervical cancer, containing the Chinese crude drug of following weight portion:
Herba Hyperici Monogyni 10 grams, Caulis Sinomenii 8 grams, Flos abelmoschi manihot 14 grams, Semen Vaccariae 4 grams, 8 grams of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 16 grams, Herba Plantaginis 14 grams, Semen Abutili 7 grams, Semen Astragali Complanati 4 grams, Herba Duchesneae Indicae 7 grams, Halloysitum Rubrum 8 grams, Fructus Amomi 2-7 gram, Spica Prunellae 17 grams, Radix Patriniae heterophyllae 6 grams, Caulis Lonicerae 8 grams, 9 grams of Radix Glycyrrhizae, Folium Artemisiae Argyi 5 grams, Serissa foetida 10 grams, Herba Pyrolae 8 grams, Herba Clinopodii Polycephali 5 grams, Caulis Hederae Sinensis 7 grams, Flos Bombacis Malabarici 6 grams, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 7 grams, Fructus Forsythiae 18 grams, Herba portulacae 20 grams, Fructus Mori 7 grams, Semen Raphani 5 grams, Semen Lepidii (Semen Descurainiae) 6 grams.
Preparation method is with embodiment 1.
Embodiment 3: a kind of pharmaceutical preparation for treating cervical cancer, containing the Chinese crude drug of following weight portion:
Herba Hyperici Monogyni 7.5 grams, Caulis Sinomenii 5.5 grams, Flos abelmoschi manihot 10 grams, Semen Vaccariae 3 grams, 5 grams of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 13 grams, Herba Plantaginis 10 grams, Semen Abutili 5 grams, Semen Astragali Complanati 3 grams, Herba Duchesneae Indicae 4.5 grams, Halloysitum Rubrum 5.5 grams, Fructus Amomi 4 grams, Spica Prunellae 12 grams, Radix Patriniae heterophyllae 4 grams, Caulis Lonicerae 5 grams, 6 grams of Radix Glycyrrhizae, Folium Artemisiae Argyi 3 grams, Serissa foetida 6.5 grams, Herba Pyrolae 5 grams, Herba Clinopodii Polycephali 3 grams, Caulis Hederae Sinensis 5 grams, Flos Bombacis Malabarici 3.5 grams, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 4.5 grams, Fructus Forsythiae 14 grams, Herba portulacae 15 grams, Fructus Mori 9.5 grams, Semen Raphani 3.5 grams, Semen Lepidii (Semen Descurainiae) 4 grams.
Preparation method is with embodiment 1.
Embodiment 4: a kind of pharmaceutical preparation for treating cervical cancer, containing the Chinese crude drug of following weight portion:
Herba Hyperici Monogyni 8 grams, Caulis Sinomenii 6 grams, Flos abelmoschi manihot 11 grams, Semen Vaccariae 3.5 grams, 6 grams of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 14 grams, Herba Plantaginis 11 grams, Semen Abutili 5.5 grams, Semen Astragali Complanati 3.5 grams, Herba Duchesneae Indicae 5 grams, Halloysitum Rubrum 6 grams, Fructus Amomi 5 grams, Spica Prunellae 13 grams, Radix Patriniae heterophyllae 5 grams, Caulis Lonicerae 5.5 grams, 7 grams of Radix Glycyrrhizae, Folium Artemisiae Argyi 4 grams, Serissa foetida 7 grams, Herba Pyrolae 6 grams, Herba Clinopodii Polycephali 4 grams, Caulis Hederae Sinensis 6 grams, Flos Bombacis Malabarici 4 grams, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 5 grams, Fructus Forsythiae 15 grams, Herba portulacae 16 grams, Fructus Mori 10.5 grams, Semen Raphani 4 grams, Semen Lepidii (Semen Descurainiae) 4.5 grams.
Preparation method is with embodiment 1.
Embodiment 5: clinical trial
5.1, physical data
In December, 2012 my institute of in December ,-2014 year accepts 180 example cases altogether and is my Out-patient Department or inpatient, wherein 20～30 years old woman 22 example, 31～40 years old woman 80 example, 41～50 years old woman 60 example, more than 50 years old woman 18 example.It is randomly divided into three groups, treatment I group, treatment group II group and observation group, often organize 60 people, two groups of ages, diseased region, clinical manifestation and the equal not statistically significant of coincident with severity degree of condition comparing difference (p > 0.05).
5.2, administering mode
Treatment group I group: give the embodiment of the present invention 3 capsule every day 3 times, each 3.Within 20 days, it was 1 course for the treatment of, according to patient's suffered from cervical cancer time length, within 1 year, takes 2～3 courses for the treatment of continuously, within 1 year, took 3-4 the course for the treatment of continuously by 2 years, more than 2 years 4-5 the courses for the treatment of；
Treatment group II group: give the embodiment of the present invention 4 capsule every day 3 times, each 3.Within 20 days, it was 1 course for the treatment of, according to patient's suffered from cervical cancer time length, within 1 year, takes 2～3 courses for the treatment of continuously, within 1 year, took 3-4 the course for the treatment of continuously by 2 years, more than 2 years 4-5 the courses for the treatment of；
Observation group: adopt chemicotherapy treatment.Chemotherapy regimen: chemotherapeutics and radiotherapy are synchronously performed.DDP (cisplatin) 40mg, is used in conjunction 3d, 5-FU1.0g once a day, is used in conjunction 3d once a day, BLM (wins enzyme element) 15mg, once a day, is all used in conjunction 3d, after getting rid of chemotherapy contraindication, each patient is each 1 course for the treatment of before radiotherapy, in radiotherapy, after radiotherapy, totally 3 courses for the treatment of.
5.3, diagnostic criteria
Complete incidence graph: tumor disappearance, clinical symptom disappearance, the time was no less than 4 weeks；
Partial rcsponse: tumor mass reduction more than 1/2, clinical symptoms disappears substantially, and the time was no less than 4 weeks；
Invalid: tumor mass reduction less than 1/2, clinical symptoms takes a turn for the better to some extent, and occurs without new tumor focus during treating；
Progress: gross tumor volume increases and/or has new tumor focus to occur.
5.4, therapeutic effect
Three groups of patient's row gynecologial examinations weekly, record cervix neoplasms is shunk back situation, records that gastrointestinal reaction, colporrhagia, flow liquid, stomachache and lower abdomen are uncomfortable etc. improves situation.2 routines of having a blood test weekly, after treatment terminates, regularly outpatient service is checked, and statistical result is referring to table 1.
Table 1 therapeutic outcome is as follows
Complete incidence graph Partial rcsponse Invalid Progress
Treatment group I group 72 8 0 0
Treatment group II group 70 6 4 0
Observation group 55 17 6 2
As it can be seen from table 1 treatment group I group effective percentage is 100%, the effective percentage for the treatment of group II group is 99.5%, and the effective percentage of observation group is 90%, but has 2 examples deterioration occur over the course for the treatment of, it can thus be seen that the scheme for the treatment of group is better than observation group.In above-mentioned therapeutic process, treatment group I group has 2 example mild fever, 2 example mild diarrhea, and 2 example skins have erythema to occur, through dealing carefully with, treatment group II group has 3 example mild fever, 3 example mild diarrhea, and 2 example skins have erythema to occur, through dealing carefully with, is all eliminated.Observation group's fever is serious, and hair drops phenomenon 40 example, and all the other cases all have diarrhoea in various degree, fever phenomenon.It can thus be seen that the medicine of the present invention is safer.
5.5, model case
Case 1: record certain, women, 44 years old, Lianyungang of Jiangsu people, pharmaceutical factory workman.Finding cervical cancer sign in unit organization physical examination, go to work as districts and cities' examination in hospital, through CT and other inspections, being diagnosed as cervical cancer, deep pulse is thin and delicate, empty big unrooted, dimly red tongue.Giving Chinese medicine embodiment 3 capsule of the present invention 2, every day 3 times, after treating 3 months, tumor disappears substantially, continues to take 1 month and strengthens curative effect, and recovery from illness is followed up a case by regular visits to 1 year and do not recurred.
Case 2: Lu, women, 36 years old, people from Weihai in Shandong province, profession, because there being colporrhagia time after sexual life, does not originally take notice of, single phenomenon increases, and neoplasm increases, white, through thin such as rice water sample, through CT and other inspections, it is diagnosed as cervical cancer, gives Chinese medicine embodiment 4 capsule of the present invention 2, every day 3 times, after treating 3 months, tumor disappears substantially, continue to take 1 month and strengthen curative effect, recovery from illness, follow up a case by regular visits to 1 year and do not recur.
Case 3: Liao, women, 57 years old, people from Linyi, Shandong, retired professor.Patient's private prosecution is suffered from abdominal pain, a small amount of bloodstain sometimes during stool, has 3 scleromas, contact bleeding by certain examination in hospital cervix uteri.Pale tongue with thin fur is white, weight in patients/height is 44/164, through CT and other inspections, is diagnosed as cervical cancer, give Chinese medicine embodiment 3 capsule of the present invention 2, every day 3 times, after treating 3 months, tumor disappears substantially, weight in patients becomes 50/164, continue to take 1 month and strengthen curative effect, recovery from illness, follow up a case by regular visits to 1 year and do not recur.
Case 4: Zhu, female, 42 years old, people from Weihai in Shandong province, laid-off worker.This patient because feeling hypogastralgia, with leucorrhea be rice water shape with abnormal flavour, defecate sometimes hemorrhage, through examination in hospital be diagnosed as cervical cancer early stage.Giving Chinese medicine embodiment 1 capsule of the present invention 2, every day 3 times, after treating 3 months, tumor disappears substantially, continues to take 1 month and strengthens curative effect, and recovery from illness is followed up a case by regular visits to 1 year and do not recurred.
Case 5: Xue, female, 35 years old, Yancheng, Jiangsu Province people, these administrative affairs of village agriculture.Patient's sexual intercourse abnormal vaginal bleeding, hypogastralgia, is cervical cancer mid-term by the section diagnosis of certain Hospital Pathological Department.Once was there is the phenomenon such as depression, suicide and refusal operative treatment in patient, gave Chinese medicine embodiment 2 capsule of the present invention 2, every day 3 times, and after treating 3 months, tumor disappears substantially, continues to take 1 month and strengthens curative effect, and recovery from illness is followed up a case by regular visits to 1 year and do not recurred.
Embodiment 6: clinical trial result
The capsule of the embodiment 3 used in the capsule alternate embodiment 5 that embodiment 1,2 is prepared, repeat embodiment 5, found that the capsule of embodiment 1,2 preparation is still equally authentic at the therapeutic effect of cervical cancer, further demonstrate that the weight portion Chinese crude drug of the present invention effect in treatment group cervical cancer.
Embodiment 7: toxicity is verified
7.1, acute toxicity test
Tested Chinese medicine preparation: the capsule manufactured by embodiment of the present invention 1-4, adds purified water by 1:2, makes solution, standby.Experimental animal: regular grade kunming mice, body weight 20g ± 5g, male and female half and half, female mice is all without pregnant.
The solution of mouse stomach Chinese medicine capsules preparation of the present invention, when given low reaches 735.5g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal.
7.1.1, result of the test shows
The maximum dosage-feeding of the capsule manufactured by mouse stomach embodiment 1-4 is 735.5g crude drug/kg/d (LD50 > 735.5g crude drug/kg).The Chinese medicine powder clinical application every day total amount of the present invention is 0.15g crude drug/kg/d to the maximum；By weighing machine, the dosis tolerata of mouse stomach capsule is 4903.3 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
7.2, long-term toxicity test for animals
Tested Chinese medicine preparation: embodiment of the present invention 2-4 gained Chinese medicine capsules, adds purified water by 1:2, makes solution, standby.Experimental animal: regular grade SD rat, body weight 210g ± 14g, male and female half and half, female rats is all without pregnant.
7.2.2, method and result:
3 kinds of Chinese medicine capsules: be divided into high, medium and low three dosage groups, per weight dosage respectively the 180 of patient's dose, 60,20 times；Experimental mouse is randomly divided into 10 groups, and wherein the capsule solution of 9 groups of difference 3 kinds of three dosage of gavage, remains 1 group of gavage normal saline (40 times of patient's dose)；All 10 groups of gavages 180 days all continuously, observe animal general toxic reaction and the order of severity, and place after death checks each position by rule of operation, and carries out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach；Through long-term feeding, all there is not toxic reaction in 10 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, it is therefore contemplated that through proved by pathology, animal is showed by 3 kinds of Chinese medicine capsules without chronic toxicity.
By two above toxicity test, it was demonstrated that the present invention is safe by the embodiment 1-4 Chinese medicine capsules made, and has no side effect, it is possible to taken by patient.

Claims (8)

1. the pharmaceutical preparation being used for treating cervical cancer, it is characterized in that, described pharmaceutical preparation includes following Chinese crude drug: Herba Hyperici Monogyni, Caulis Sinomenii, Flos abelmoschi manihot, Semen Vaccariae, Pericarpium Citri Reticulatae Viride, Herba Taraxaci, Herba Plantaginis, Semen Abutili, Semen Astragali Complanati, Herba Duchesneae Indicae, Halloysitum Rubrum, Fructus Amomi, Spica Prunellae, Radix Patriniae heterophyllae, Caulis Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi, Serissa foetida, Herba Pyrolae, Herba Clinopodii Polycephali, Caulis Hederae Sinensis, Flos Bombacis Malabarici, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Fructus Forsythiae, Herba portulacae, Fructus Mori, Semen Raphani, Semen Lepidii (Semen Descurainiae).
null2. pharmaceutical preparation according to claim 1，It is characterized in that，Described pharmaceutical preparation includes following weight portion Chinese crude drug: Herba Hyperici Monogyni 5-10 part、Caulis Sinomenii 3-8 part、Flos abelmoschi manihot 5-14 part、Semen Vaccariae 1-4 part、Pericarpium Citri Reticulatae Viride 2-8 part、Herba Taraxaci 10-16 part、Herba Plantaginis 6-14 part、Semen Abutili 3-7 part、Semen Astragali Complanati 1-4 part、Herba Duchesneae Indicae 2-7 part、Halloysitum Rubrum 3-8 part、Fructus Amomi 2-7 part、Spica Prunellae 9-17 part、Radix Patriniae heterophyllae 3-6 part、Caulis Lonicerae 2-8 part、Radix Glycyrrhizae 3-9 part、Folium Artemisiae Argyi 1-5 part、Serissa foetida 3-10 part、Herba Pyrolae 2-8 part、Herba Clinopodii Polycephali 1-5 part、Caulis Hederae Sinensis 3-7 part、Flos Bombacis Malabarici 1-6 part、Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 2-7 part、Fructus Forsythiae 10-18 part、Herba portulacae 10-20 part、Fructus Mori 12-7 part、Semen Raphani 2-5 part、Semen Lepidii (Semen Descurainiae) 2-6 part.
3. pharmaceutical preparation according to claim 1, it is characterized in that, described pharmaceutical preparation includes following weight portion Chinese crude drug: Herba Hyperici Monogyni 7.5 parts, Caulis Sinomenii 5.5 parts, Flos abelmoschi manihot 10 parts, Semen Vaccariae 3 parts, 5 parts of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 13 parts, Herba Plantaginis 10 parts, Semen Abutili 5 parts, Semen Astragali Complanati 3 parts, Herba Duchesneae Indicae 4.5 parts, Halloysitum Rubrum 5.5 parts, Fructus Amomi 4 parts, Spica Prunellae 12 parts, Radix Patriniae heterophyllae 4 parts, Caulis Lonicerae 5 parts, 6 parts of Radix Glycyrrhizae, Folium Artemisiae Argyi 3 parts, Serissa foetida 6.5 parts, Herba Pyrolae 5 parts, Herba Clinopodii Polycephali 3 parts, Caulis Hederae Sinensis 5 parts, Flos Bombacis Malabarici 3.5 parts, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 4.5 parts, Fructus Forsythiae 14 parts, Herba portulacae 15 parts, Fructus Mori 9.5 parts, Semen Raphani 3.5 parts, Semen Lepidii (Semen Descurainiae) 4 parts.
4. pharmaceutical preparation according to claim 1, it is characterized in that, described pharmaceutical preparation includes following weight portion Chinese crude drug: Herba Hyperici Monogyni 8 parts, Caulis Sinomenii 6 parts, Flos abelmoschi manihot 11 parts, Semen Vaccariae 3.5 parts, 6 parts of Pericarpium Citri Reticulatae Viride, Herba Taraxaci 14 parts, Herba Plantaginis 11 parts, Semen Abutili 5.5 parts, Semen Astragali Complanati 3.5 parts, Herba Duchesneae Indicae 5 parts, Halloysitum Rubrum 6 parts, Fructus Amomi 5 parts, Spica Prunellae 13 parts, Radix Patriniae heterophyllae 5 parts, Caulis Lonicerae 5.5 parts, 7 parts of Radix Glycyrrhizae, Folium Artemisiae Argyi 4 parts, Serissa foetida 7 parts, Herba Pyrolae 6 parts, Herba Clinopodii Polycephali 4 parts, Caulis Hederae Sinensis 6 parts, Flos Bombacis Malabarici 4 parts, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp. 5 parts, Fructus Forsythiae 15 parts, Herba portulacae 16 parts, Fructus Mori 10.5 parts, Semen Raphani 4 parts, Semen Lepidii (Semen Descurainiae) 4.5 parts.
5. pharmaceutical preparation according to claim 1, it is characterised in that described pharmaceutical dosage form one in granule, capsule, tablet, injection, tincture, suppository, pill, syrup, mixture, powder, lotion, membrane, drop pill.
6. pharmaceutical preparation according to claim 1, it is characterised in that described pharmaceutical dosage form is selected from capsule.
7. the preparation method of the pharmaceutical preparation described in a claim 1, it is characterised in that concrete step is:
(1) take Folium Artemisiae Argyi, Radix Patriniae heterophyllae, Fructus Forsythiae, Fructus Mori, Herba Pyrolae, Herba Clinopodii Polycephali, Serissa foetida, Halloysitum Rubrum, Flos Bombacis Malabarici, Saurauia tristyla DC. var. oldhamii (Hemsl.) Finet & Gagncp., Flos abelmoschi manihot, Herba Taraxaci, Herba Plantaginis, Spica Prunellae and Herba portulacae and soak 1.5-3.0 hour, the boiled 10-20min of intense fire, slow fire 1.5-2.5 hour, decoct twice, merge twice filtrate, being evaporated to 90 DEG C, density is the extractum of 1.10, standby；
(2) take Caulis Lonicerae, Caulis Hederae Sinensis, Herba Hyperici Monogyni, Caulis Sinomenii, Pericarpium Citri Reticulatae Viride, Semen Abutili and Fructus Amomi to grind to form coarse powder and add 70% ethanol extraction 2 times, each 2 hours, merge medicinal liquid, stand 24 hours, standby；
(3) extracting liquorice, Semen Raphani, Semen Lepidii (Semen Descurainiae), Semen Vaccariae, Semen Astragali Complanati and Herba Duchesneae Indicae are ground into appropriate 70% ethanol extraction of fine powder 2 times, each 1.5 hours, collect extracting solution, merge medicinal liquid, stand 24 hours, standby；
(4) taking the supernatant prepared in (2nd) and (3) step, decompression recycling ethanol, be concentrated into 70 DEG C, density is the extractum of 1.03, standby；
(5) the extractum mix homogeneously of step (1) and (4) is obtained mixture, prepare into pharmaceutical preparation with pharmaceutically acceptable adjuvant.
8. pharmaceutical preparation according to claim 1, it is characterised in that described pharmaceutical preparation purposes in the medicine in preparation cervical cancer.
CN201610141673.8A 2016-03-12 2016-03-12 Medicinal preparation for treating cervical cancer and application thereof Withdrawn CN105770691A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610141673.8A CN105770691A (en) 2016-03-12 2016-03-12 Medicinal preparation for treating cervical cancer and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610141673.8A CN105770691A (en) 2016-03-12 2016-03-12 Medicinal preparation for treating cervical cancer and application thereof

Publications (1)

Publication Number Publication Date
CN105770691A true CN105770691A (en) 2016-07-20

Family

ID=56392604

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610141673.8A Withdrawn CN105770691A (en) 2016-03-12 2016-03-12 Medicinal preparation for treating cervical cancer and application thereof

Country Status (1)

Country Link
CN (1) CN105770691A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108741245A (en) * 2018-05-04 2018-11-06 四川生命源健康管理有限公司 Prevent the plastotype trousers of cervical carcinoma
CN112022964A (en) * 2020-10-09 2020-12-04 杨大华 Traditional Chinese medicine composition for preventing and treating cervical cancer and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157737A (en) * 1996-10-24 1997-08-27 张文善 ''Shanzhiai'' oral dosage
CN104840596A (en) * 2015-05-29 2015-08-19 鲁文娟 Traditional Chinese medicine for treating qi-blood deficient cervical carcinoma and preparation method of traditional Chinese medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157737A (en) * 1996-10-24 1997-08-27 张文善 ''Shanzhiai'' oral dosage
CN104840596A (en) * 2015-05-29 2015-08-19 鲁文娟 Traditional Chinese medicine for treating qi-blood deficient cervical carcinoma and preparation method of traditional Chinese medicine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108741245A (en) * 2018-05-04 2018-11-06 四川生命源健康管理有限公司 Prevent the plastotype trousers of cervical carcinoma
CN112022964A (en) * 2020-10-09 2020-12-04 杨大华 Traditional Chinese medicine composition for preventing and treating cervical cancer and preparation method thereof

Similar Documents

Publication Publication Date Title
CN104288701A (en) Traditional Chinese medicine composition for treating cholecystitis
CN105213974A (en) One treats lymphadenomatous Chinese medicine composition and application thereof
CN104524071A (en) Pharmaceutical composition for treating primary renal disease and application thereof
CN101569738A (en) Plaster for treating mastitis, hyperplasia of mammary glands, breast lumps, join thydrops, traumatic injury, preparation method and application thereof
CN105770691A (en) Medicinal preparation for treating cervical cancer and application thereof
CN104587206A (en) Medicament for treating bedsore and preparation method of medicament
CN105749127A (en) Pharmaceutic preparation for treating stomach cancer and application thereof
CN105521246A (en) Medicinal preparation for treating lung cancer and applications of medicinal preparation
CN105833209B (en) Traditional Chinese medicine composition for treating endometriosis
CN105106696A (en) Traditional Chinese medicinal composition for treating chronic prostatitis
CN104491670A (en) Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease
CN100371016C (en) Chinese traditional medicine preparation for curing mastopathy in installments
CN104288581A (en) Traditional Chinese medicine for treating threatened abortion
CN104257871B (en) Scorching pharmaceutical composition of the acute lymphatic meshwork of type and preparation method thereof is accumulate for treating damp and hot poison
CN103494991B (en) Traditional Chinese medicine preparation for treating female metrorrhagia and preparation method thereof
CN105169111A (en) Traditional Chinese medicine composition for treating chronic urticaria and application of traditional Chinese medicine composition
CN105726823A (en) Chinese herbal preparation for treating allergic rhinitis and preparation method of Chinese herbal preparation
CN105250634A (en) Traditional Chinese medicine composition for treating postpartum constipation and application thereof
CN105412695A (en) Medicine for treating cow endometritis and preparation method thereof
CN104189400B (en) Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof
CN105597004A (en) Traditional Chinese medicine combination for treating cancer
CN105327299A (en) Medicine for treating idiopathic thrombocytopenic purpura
CN105288344A (en) Traditional Chinese medicinal composition for treating liver and gall calculi, and application thereof
CN105213885A (en) A kind of pharmaceutical composition and application thereof for the treatment of acute pancreatitis
CN104436043A (en) Analgesic anti-inflammatory ointment for treating sore and ulcer yang syndrome and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20160720

WW01 Invention patent application withdrawn after publication