CN105412695A - Medicine for treating cow endometritis and preparation method thereof - Google Patents

Medicine for treating cow endometritis and preparation method thereof Download PDF

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Publication number
CN105412695A
CN105412695A CN201510878215.8A CN201510878215A CN105412695A CN 105412695 A CN105412695 A CN 105412695A CN 201510878215 A CN201510878215 A CN 201510878215A CN 105412695 A CN105412695 A CN 105412695A
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weight portion
herba
radix
medicine
mixed powder
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黄河
李鑫
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Shandong New Hope Liuhe Group Co Ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Abstract

The invention discloses a medicine for treating cow endometritis and a preparation method thereof. The medicine is prepared from endives, herba andrographitis, hemiphragma heterophyllum, patience dock roots, lygodium japonicum, pouzolzia zeylanica, serissa serissoides, herba portulacae, peperomia blanda, philippine violet herb, spinach beet, hematoxylon, beautiful sweetgum fruits, lamiophlomis rotate, the seed of cowherb, lumbricus, herba lycopi, moutan bark, huechys sanguinea, monthly rose, vervain, frankincense, sargentgloryvine stems, angelica sinensis, liquorice, cowpea roots, semen coicis, shorthairy antenoron herb and white atractylodes rhizome. The medicine has the advantages that the main effects of clearing away heat and toxic materials and promoting blood circulation to remove blood stasis are achieved, the auxiliary effects of diminishing inflammation and relieving pain are achieved, the resistance ability is enhanced, the treatment course is short, the treatment effect is good, no toxic or side effect is produced, the cost is low, the illness state can be effectively controlled, and cow endometritis is not likely to relapse after being cured.

Description

Medicine being used for the treatment of cattle endometritis and preparation method thereof
Technical field
The present invention relates to field of veterinary, particularly relate to a kind of medicine being used for the treatment of cattle endometritis and preparation method thereof.
Background technology
Endometritis when cow is given a birth or puerperal caused by infected by microbes, be one of infertile common cause of milch cow.The endometritis of cattle is the major reason causing cattle breeding difficulty, is also one of thorny problem affecting Cow product, should give attention.
Puerperal, acute endometritis mainly occurred in puerperal, sustain damage due to birth canal in childbirth and practise midwifery or take off because of placenta retention, uterus, miscarriage, subinvolution of uterus etc., uterus is infected, and causes uterus acute illness.There is body temperature risings, appetite, listless in sick cattle, the dirty redness of lochia of discharge, frowziness or fragment of tissue, even there is purulent secretion.Time lengthening (more than 10-14 days) examination per rectum that lochia is discharged can feel that cornua uteri is thick, and bounce back bad, wall thickness, contractile response is weak or do not have, and has pain when inflammation is serious, if treat in time, prognosis bona, comparatively fast can recover fertility.But as treatment delay or improper; septicemia or majority may be caused to change chronic endometritis into, become long-term Repeat breeding cow or can secondary miscarriage or because the migration of purulence embolus is in other orga-nogenesis abscess (common as wrist, instep, ball-joint purulent inflammation).
The cause of disease
Cause the main cause of cattle endometritis to be that delivery room sanitary condition is poor, the pudendum of down calver, root of the tail portion pollute feces and thorough washing and sterilizing; When practise midwifery or stripping afterbirth, arm, the sterilization of instruments of patient are tight, and placenta retention corruption is decomposed, lochia stagnation etc., all can cause endometrium infection in puerperal.Metritic antibacterial can be caused puerperal in early days to have: suppurative actinomycetes, actinomyces pseudonecrophorus, bacteroid, escherichia coli, Hemolytic streptococcus, Bacillus proteus, pseudomonas, clostridium.Postpartum therapy not in time or obstinate often transfer chronic metritis to, intrauterine becomes single suppurative actinomycotic infection by multiple mixed vaccine.In addition, hydrometra, twins uterus severe dilation, injury of birth canal, low blood calcium, Parturient Environment are dirty etc. can cause uterine infection.Extremely cold very hot time, passive protective physical fitness reduces and feeding and management is improper that metritic sickness rate all can be made to raise.In addition, some infectious disease such as trichomoniasis, leptospira, infectious bovine rhinotrachetis, viral diarrhea etc. can cause uterus inflammation.Chronic metritis is many to be transformed by acute inflammation, and what have causes because breeding sterilization is tight, does not have obvious General Symptoms.
Clinical symptoms
Primary disease was fallen ill usually within one week puerperal, and the lighter, without General Symptoms, oestruses normal, but can not become pregnant; Serious in General Symptoms, as body temperature raises, accelerated breathing, spirit is depressed, and appetite declines, and ruminates the performances such as minimizing.Suffer from cattle haunch, lift tail, sometimes exert duty, frequently flow out a large amount of dirty or brown color mucus purulent secretion from vagina, have bad smell, include floccule or afterbirth fragment, often adhere to root of the tail, form dry crusts.Examination per rectum, cornua uteri is thicker, and Uterus wall thickens.If during intrauterine accumulation exudate, that touches has fluctuation.
Modern medicine mainly comprises for the Therapeutic Method of cattle endometritis: 1. intrauterine target infusion chemotherapy: the sick cattle for acute and chronic endometritis uses medicine to have iodine glycerol, oxytetracycline, chlortetracycline or ethacridine etc.Penicillin, streptomycin, cod-liver oil etc. are had for chronic, recessive endometritis Niu Suoyong medicine.2. hormonotherapy: hormone used comprises prostate hormone, Cloprostenol etc.
But western modern medicine curative effect is undesirable, and the course for the treatment of is long, price, and side effect is larger.
The traditional Chinese medical science thinks that the formation of primary disease is main and wet, heat, malicious heresy are in close relations, many because of menstrual period, puerperal, when vessels of the uterus inanition, wet, heat, malicious heresy are taken advantage of a weak point, fighting with deteriorated blood ties in the heart, or injure punching, appoint, dai channel, dai channel is failed to keep an appointment, conception vessel is solid, or wet, heat, poison are stopped up to hinder and freely not formed in chong channel, QI-blood circulation.At the beginning of morbidity, stop up due to pathogen and contain, healthy energy rises vigorously to resist with it, thus the existing heating of multilist, shiver with cold, wet, heat, poison pent up in vessels of the uterus, QI and blood obstructed, therefore pain is also comparatively violent, and wet, heat, poison follow through bet, then profuse leukorrhea, and chromaticness is abnormal.Violent friendship through good and evil is striven, if healthy energy is gradually contained, and pathogen degradation, then patient's condition is gradually delayed; If the positive deficiency of vital energy declines, evil poison is flourishing, then patient's condition can be caused to worsen further.Also have non-menstrual period, puerperal, but because health preserving is usually unclean, the ground of sitting cold-damp, or paddle in spite of the rain, also can cause invading in the heresy of cold-damp, the stasis of blood is stagnant in vessels of the uterus, and see stomachache connect and waist sacrum, leukorrhagia abnormal; Or ferritic insufficiency of kidney-YANG, after experiencing damp, be detained in vivo with the passing of time, check yang-energy, make to tremble with fear by interior life, conversion of dampness into cold etc., cause vessels of the uterus deficiency and coldness, and continuous and dull pain in the abdomen, leukorrhagia exception etc.
But Chinese medicine cattle endometritis can avoid the toxic and side effects for the treatment of with western, and determined curative effect, rapid-action, and processing technology is easy, medicament is easy to manufacture, and cost price is cheap, and healing time is short, not easily recurs after healing.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of medicine being used for the treatment of cattle endometritis, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, have based on heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hold concurrently with anti-inflammatory analgetic effect, its resistivity can be strengthened, the course for the treatment of is shorter, curative effect is better, and have no side effect, cost price is cheap, can effective symptom management, not easily recur after healing.
In order to realize foregoing invention object, the invention provides a kind of medicine being used for the treatment of cattle endometritis, described medicine comprises following raw medicinal material: Herba Sonchi Arvensis, Herba Andrographis, Herba hemipharagmatis heterophylli, Radix Rumicis Patientiae, Spora Lygodii, Herba Gonostegiae hirtae, Radix Serissae, Herba Portulacae, Herba Peperomiae Dindygulensis, Herba Violae dissectae, Radix Betae, Lignum Sappan, Fructus Liquidambaris, Radix Lamiophlomidis Rotatae, Semen Vaccariae, Pheretima, Herba Lycopi, Cortex Moutan, Huechys sanguinea De Geer., Flos Rosae Chinensis, Herba Verbenae, Olibanum, Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix vignae sinensis, Semen Coicis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) and the Rhizoma Atractylodis Macrocephalae.
In described medicine, the parts by weight of each raw medicinal material can be preferably: Herba Sonchi Arvensis 10-15 weight portion, Herba Andrographis 20-26 weight portion, Herba hemipharagmatis heterophylli 13-18 weight portion, Radix Rumicis Patientiae 16-22 weight portion, Spora Lygodii 21-27 weight portion, Herba Gonostegiae hirtae 15-25 weight portion, Radix Serissae 8-15 weight portion, Herba Portulacae 21-28 weight portion, Herba Peperomiae Dindygulensis 13-18 weight portion, Herba Violae dissectae 10-16 weight portion, Radix Betae 15-26 weight portion, Lignum Sappan 10-16 weight portion, Fructus Liquidambaris 13-18 weight portion, Radix Lamiophlomidis Rotatae 6-9 weight portion, Semen Vaccariae 10-17 weight portion, Pheretima 8-12 weight portion, Herba Lycopi 12-18 weight portion, Cortex Moutan 8-14 weight portion, Huechys sanguinea De Geer. 10-16 weight portion, Flos Rosae Chinensis 15-26 weight portion, Herba Verbenae 10-22 weight portion, Olibanum 18-23 weight portion, Caulis Sargentodoxae 11-22 weight portion, Radix Angelicae Sinensis 22-28 weight portion, Radix Glycyrrhizae 15-26 weight portion, Radix vignae sinensis 15-19 weight portion, Semen Coicis 21-29 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10-18 weight portion and Rhizoma Atractylodis Macrocephalae 13-24 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material also can be preferably: Herba Sonchi Arvensis 13 weight portion, Herba Andrographis 22 weight portion, Herba hemipharagmatis heterophylli 15 weight portion, Radix Rumicis Patientiae 19 weight portion, Spora Lygodii 23 weight portion, Herba Gonostegiae hirtae 18 weight portion, Radix Serissae 9 weight portion, Herba Portulacae 22 weight portion, Herba Peperomiae Dindygulensis 14 weight portion, Herba Violae dissectae 11 weight portion, Radix Betae 19 weight portion, Lignum Sappan 15 weight portion, Fructus Liquidambaris 16 weight portion, Radix Lamiophlomidis Rotatae 8 weight portion, Semen Vaccariae 13 weight portion, Pheretima 9 weight portion, Herba Lycopi 13 weight portion, Cortex Moutan 11 weight portion, Huechys sanguinea De Geer. 12 weight portion, Flos Rosae Chinensis 21 weight portion, Herba Verbenae 18 weight portion, Olibanum 19 weight portion, Caulis Sargentodoxae 21 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae 23 weight portion, Radix vignae sinensis 17 weight portion, Semen Coicis 23 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15 weight portion and the Rhizoma Atractylodis Macrocephalae 21 weight portion.
Preferably, described medicine also comprises Rhizoma Begoniae Fimbristipulatae, Rhizoma Curcumae, Herba youngiae japonicae, Cortex Myricae Rubrae (Cortex Myricae Esculentae) and Radix Salviae Miltiorrhizae.
In described medicine, the parts by weight of each raw medicinal material can also be preferably: Herba Sonchi Arvensis 10-15 weight portion, Herba Andrographis 20-26 weight portion, Herba hemipharagmatis heterophylli 13-18 weight portion, Radix Rumicis Patientiae 16-22 weight portion, Spora Lygodii 21-27 weight portion, Herba Gonostegiae hirtae 15-25 weight portion, Radix Serissae 8-15 weight portion, Herba Portulacae 21-28 weight portion, Herba Peperomiae Dindygulensis 13-18 weight portion, Herba Violae dissectae 10-16 weight portion, Radix Betae 15-26 weight portion, Lignum Sappan 10-16 weight portion, Fructus Liquidambaris 13-18 weight portion, Radix Lamiophlomidis Rotatae 6-9 weight portion, Semen Vaccariae 10-17 weight portion, Pheretima 8-12 weight portion, Herba Lycopi 12-18 weight portion, Cortex Moutan 8-14 weight portion, Huechys sanguinea De Geer. 10-16 weight portion, Flos Rosae Chinensis 15-26 weight portion, Herba Verbenae 10-22 weight portion, Olibanum 18-23 weight portion, Caulis Sargentodoxae 11-22 weight portion, Radix Angelicae Sinensis 22-28 weight portion, Radix Glycyrrhizae 15-26 weight portion, Radix vignae sinensis 15-19 weight portion, Semen Coicis 21-29 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10-18 weight portion and Rhizoma Atractylodis Macrocephalae 13-24 weight portion, Rhizoma Begoniae Fimbristipulatae 11-19 weight portion, Rhizoma Curcumae 15-23 weight portion, Herba youngiae japonicae 10-19 weight portion, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 12-19 weight portion and Radix Salviae Miltiorrhizae 21-26 weight portion.
In described medicine, the parts by weight of each raw medicinal material also can be preferably: Herba Sonchi Arvensis 13 weight portion, Herba Andrographis 22 weight portion, Herba hemipharagmatis heterophylli 15 weight portion, Radix Rumicis Patientiae 19 weight portion, Spora Lygodii 23 weight portion, Herba Gonostegiae hirtae 18 weight portion, Radix Serissae 9 weight portion, Herba Portulacae 22 weight portion, Herba Peperomiae Dindygulensis 14 weight portion, Herba Violae dissectae 11 weight portion, Radix Betae 19 weight portion, Lignum Sappan 15 weight portion, Fructus Liquidambaris 16 weight portion, Radix Lamiophlomidis Rotatae 8 weight portion, Semen Vaccariae 13 weight portion, Pheretima 9 weight portion, Herba Lycopi 13 weight portion, Cortex Moutan 11 weight portion, Huechys sanguinea De Geer. 12 weight portion, Flos Rosae Chinensis 21 weight portion, Herba Verbenae 18 weight portion, Olibanum 19 weight portion, Caulis Sargentodoxae 21 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae 23 weight portion, Radix vignae sinensis 17 weight portion, Semen Coicis 23 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15 weight portion, the Rhizoma Atractylodis Macrocephalae 21 weight portion, Rhizoma Begoniae Fimbristipulatae 17 weight portion, Rhizoma Curcumae 17 weight portion, Herba youngiae japonicae 18 weight portion, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13 weight portion and Radix Salviae Miltiorrhizae 23 weight portion.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method being used for the treatment of the medicine of cattle endometritis, and when the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method being used for the treatment of the medicine of cattle endometritis, and when the dosage form of described medicine is decoction, its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour; Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use; Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour; Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
The beneficial effect that embodiment of the present invention technical scheme is brought is: medicine of the present invention has based on heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hold concurrently with the effect of anti-inflammatory analgetic, treatment cattle endometritis, and its resistivity can be strengthened, the course for the treatment of is shorter, and curative effect is better, have no side effect, cost price is cheap, can effective symptom management, not easily recurs after healing.
Detailed description of the invention
The traditional Chinese medical science thinks that the formation of cattle endometritis is main and wet, heat, malicious heresy are in close relations, many because of menstrual period, puerperal, when vessels of the uterus inanition, wet, heat, malicious heresy are taken advantage of a weak point, fighting with deteriorated blood ties in the heart, or injure punching, appoint, dai channel, dai channel is failed to keep an appointment, conception vessel is solid, or wet, heat, poison are stopped up to hinder and freely not formed in chong channel, QI-blood circulation.At the beginning of morbidity, stop up due to pathogen and contain, healthy energy rises vigorously to resist with it, thus the existing heating of multilist, shiver with cold, wet, heat, poison pent up in vessels of the uterus, QI and blood obstructed, therefore pain is also comparatively violent, and wet, heat, poison follow through bet, then profuse leukorrhea, and chromaticness is abnormal.Violent friendship through good and evil is striven, if healthy energy is gradually contained, and pathogen degradation, then patient's condition is gradually delayed; If the positive deficiency of vital energy declines, evil poison is flourishing, then patient's condition can be caused to worsen further.Also have non-menstrual period, puerperal, but because health preserving is usually unclean, the ground of sitting cold-damp, or paddle in spite of the rain, also can cause invading in the heresy of cold-damp, the stasis of blood is stagnant in vessels of the uterus, and see stomachache connect and waist sacrum, leukorrhagia abnormal; Or ferritic insufficiency of kidney-YANG, after experiencing damp, be detained in vivo with the passing of time, check yang-energy, make to tremble with fear by interior life, conversion of dampness into cold etc., cause vessels of the uterus deficiency and coldness, and continuous and dull pain in the abdomen, leukorrhagia exception etc.
Therefore, medicine of the present invention is based on heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, hold concurrently with anti-inflammatory analgetic, provide a kind of medicine being used for the treatment of cattle endometritis, medicine comprises following raw medicinal material: Herba Sonchi Arvensis, Herba Andrographis, Herba hemipharagmatis heterophylli, Radix Rumicis Patientiae, Spora Lygodii, Herba Gonostegiae hirtae, Radix Serissae, Herba Portulacae, Herba Peperomiae Dindygulensis, Herba Violae dissectae, Radix Betae, Lignum Sappan, Fructus Liquidambaris, Radix Lamiophlomidis Rotatae, Semen Vaccariae, Pheretima, Herba Lycopi, Cortex Moutan, Huechys sanguinea De Geer., Flos Rosae Chinensis, Herba Verbenae, Olibanum, Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix vignae sinensis, Semen Coicis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) and the Rhizoma Atractylodis Macrocephalae.Preferably, Rhizoma Begoniae Fimbristipulatae, Rhizoma Curcumae, Herba youngiae japonicae, Cortex Myricae Rubrae (Cortex Myricae Esculentae) and Radix Salviae Miltiorrhizae.In its side, Herba Sonchi Arvensis, Herba Andrographis, Herba hemipharagmatis heterophylli, Radix Rumicis Patientiae, Spora Lygodii, Herba Gonostegiae hirtae, Radix Serissae, Herba Portulacae, Herba Peperomiae Dindygulensis, Herba Violae dissectae, Radix Betae heat-clearing and toxic substances removing; Lignum Sappan, Fructus Liquidambaris, Radix Lamiophlomidis Rotatae, Semen Vaccariae, Pheretima, Herba Lycopi, Cortex Moutan, Huechys sanguinea De Geer., Flos Rosae Chinensis, Herba Verbenae blood circulation promoting and blood stasis dispelling; Chinese Angelica blood replonishing QI invigorating; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription; Radix vignae sinensis, Semen Coicis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI; Rhizoma Begoniae Fimbristipulatae, Olibanum, Rhizoma Curcumae, Caulis Sargentodoxae, Herba youngiae japonicae, Cortex Myricae Rubrae (Cortex Myricae Esculentae), Radix Salviae Miltiorrhizae anti-inflammatory analgetic.Make a general survey of full side, compatibility is rigorous.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Herba Sonchi Arvensis: bitter in the mouth; Cold in nature.Heat-clearing and toxic substances removing; Promoting diuresis and pus discharge; Cooling blood for hemostasis.Main laryngopharynx swelling and pain; Furuncle toxic swelling; Hemorrhoid; Acute bacillary dysentery; Intestinal is scorching; Lung abscess; Acute appendicitis; Leaf blood; Epistaxis; Spitting of blood; Hematuria; Have blood in stool; Metrorrhagia.1. " Hebei Chinese medicine handbook ": heat-clearing and toxic substances removing.Control acute bacillary dysentery, acute laryngitis, internal hemorrhoid is deviate from.2. " the common identification obscuring Chinese herbal medicine ": control leucorrhea and postnatal blood stasis stomachache, appendicitis.
Herba Andrographis: bitter in the mouth; Cold in nature.GUIXIN; Lung; Large intestine; Urinary bladder channel.Heat-clearing and toxic substances removing; Pathogenic fire purging; Dampness.Main anemopyretic cold; Epidemic febrile disease is generated heat; Cough due to lung-heat; Pertussis; Lung abscess; Laryngopharynx swelling and pain; Jaundice due to damp-heat; Stranguria; Erysipelas; Skin infection carbuncle; Eczema; Venom.
Herba hemipharagmatis heterophylli: be the herb of goatweed Herba hemipharagmatis heterophylli.Taste is micro-sweet; Light; Warm in nature.GUIXIN; Liver Channel.Expelling wind and removing dampness; Heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Amenorrhea is suffered from abdominal pain; Scrofula; Skin ulcer swells noxious dampness; Pharyngalgia; Gingivitis; Traumatic injury.
Radix Rumicis Patientiae: be the root of polygonaceae plant Rumex patientia Linn..Bitter, sour, cold.Cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing.For dysfunctional uterine hemorrhage, spit blood, spitting of blood, epistaxis, gingival hemorrhage, tail, duodenal hemorrhage, have blood in stool, purpura, constipation, edema; Scabies is controlled in external, furuncle, seborrheic dermatitis.
Spora Lygodii: be the spore of Lygodiaceae plant Spora Lygodii.Sweet; Light; Cold; Return small intestinal; Spleen; Urinary bladder channel.Heat-clearing and toxic substances removing; Relieving stranguria by diuresis.Main pyretic stranguria; Stranguria with blood; Sha Lin; Nebulousurine; Woman's leukorrhagia; Water damp-edema is full; Damp-heat dysentery; Jaundice due to damp-heat; Spit blood; Epistaxis; Hematuria; Traumatic hemorrhage.
Herba Gonostegiae hirtae: be the whole herb with root of contrayerva Herba Gonostegiae Hirtae.Sweet; Micro-hardship; Cool in nature.Heat-clearing and toxic substances removing; Spleen invigorating removing food stagnancy; Inducing diuresis and reducing edema; Dissipating blood stasis stops blooding.Main acute mastitis; Toxic swelling; Dysentery; Dyspepsia; Abdominal pain due to retention of food; Glycoside amasss; Leukorrhagia; Edema; Dysuria; Dysmenorrhea; Traumatic injury; Hemoptysis; Spit blood; Traumatic hemorrhage.
Radix Serissae: toil; Cool.Return liver; Spleen channel.Dispel the wind; Dampness removing; Heat clearing away; Removing toxic substances.Main flu; Icterohepatitis; Oedema due to nephritis; Cough; Laryngalgia; Keratitis; Intestinal is scorching; Dysentery; Lumbago and skelalgia; Hemoptysis; Hematuria; Women's amenorrhea; Leucorrhea; Infantile malnutrition; Infantile convulsion; Acute toothache; Swollen ulcer drug; Traumatic injury.
Herba Portulacae: acid, cold.Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For bacillary dysentery, acute gastroenteritis, acute appendicitis, mastitis, bleeding hemorrhoids, leucorrhea; Furuncle swelling toxin is controlled in external, eczema, herpes zoster.
Herba Peperomiae Dindygulensis: pungent; Cool.Return lung; Spleen; Liver; Kidney channel.Heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Inducing diuresis to remove edema.Main lung-heat cough with asthma; Measles; Sore; Cancerous protuberance; Burn and scald; Traumatic injury; Oedema due to nephritis.
Herba Violae dissectae: for Violaceae plants herb or root, the rhizome of special decomposite leaf common violet.Bitter in the mouth; Cold in nature.GUIXIN; Gallbladder; Spleen; Liver Channel.Heat-clearing and toxic substances removing; Inducing diuresis and reducing edema.Main furuncle swelling toxin; Measles pyretic toxicity; Pneumonia; Pleuritis; Stranguria with turbid discharge; Leucorrhea; Nephritis.
Radix Betae: another name Radix Betae.For stem, the leaf of chenopod Radix Betae.Sweet; Bitter; Cold in nature.Return lung; Kidney; Large intestine channel.Heat-clearing and toxic substances removing; Clots absorbing stops blooding.Row calentura time main; Hemorrhoid; Measles is sent out not smooth thoroughly; Spit blood; Pyretic toxicity dysentery; Amenorrhea; Stranguria with turbid discharge; Carbuncle; Traumatic injury; Snakeworm hinders.
Lignum Sappan: sweet; Salty; Flat.GUIXIN; Liver; Stomach; Large intestine channel.Blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.Housewife people's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus.
Fructus Liquidambaris: bitter is flat; Return liver, kidney channel." detailed outline is picked up any lost article from the road ": " maple fruit, tree like Cortex Populi dividianae, inner circle as honeycomb, i.e. Fructus Liquidambaris.The large acupoints of twelve meridians that can pass through of its property, therefore " the lifesaving sea of bitterness " harnesses the river, swelling is with it, can search by FUSHUI also with it." " modern Practical Chinese medicinal ": " ashing is outer for skin exudative dermatitis, anal fistula etc., has convergence, antiinflammatory, disinfective action." dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Radix Lamiophlomidis Rotatae: sweet in the mouth; Bitter; Property is put down.Blood circulation promoting and blood stasis dispelling; Reducing swelling and alleviating pain.Main traumatic injury; Bones and muscles pain; Arthralgia; Dysmenorrhea; Metrorrhagia.
Semen Vaccariae: bitter is flat; Return liver, stomach warp.Can promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, lactogenesis of invigorating blood circulation, expedite the emergence of stimulating milk secretion, thymus dredging in puerperal.For blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, stranguria caused by urinary stone.
Pheretima: salty, cold.Return liver, spleen, urinary bladder channel.Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Herba Lycopi: bitter, pungent, tepor.Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Huechys sanguinea De Geer.: be the entirety of Cicadidae animal Huechys sanguinea, brachypterism Huechys sanguinea De Geer., brown wing Huechys sanguinea De Geer..Bitter in the mouth; Pungent; Property is put down.GUIXIN; Liver; Gallbladder meridian.Removing blood stasis with potent drugs; Eliminating stagnation; Rose poison.Main blood stasis amenorrhea; Lumbago; Infertile scrofula; Tinea skin ulcer; Lyssodexis.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer." " Japan hanako materia medica ": " except pathogen, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, logical menstruation, disappear and flutter damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of heat in blood.Therefore to diseases such as intense heat in the blood, Liver and kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.
Flos Rosae Chinensis: Flos Rosae Chinensis is not only the gorgeous ornamental flower of florescence long, fragrant color, and be gynecological's good medicine simply.The traditional Chinese medical science is thought, Chinese rose sweet in the mouth, warm in nature, enters Liver Channel, has effect of promoting blood flow to regulate menstruation, subduing swelling and detoxicating.Because the blood stasis dispelling of Flos Rosae Chinensis, circulation of qi promoting, analgesic effect are obvious, therefore be often used to the stasis for the treatment of stagnation of liver-QI, menoxenia, dysmenorrhea, amenorrhea and distending pain in the chest and hypochondrium.Traumatic injury, pain caused by ecchymoma, swollen ulcer drug, scrofula.Clinical report, there is amenorrhea in women or menstruation is thin, color is light and amount less, lower abdominal pain, have the smooth and constipation due to dry stool of spirit etc. concurrently, or occur above-mentioned symptom in menstrual phase, with winning, spring soup therapeutic effect is good.
Herba Verbenae: bitter, cool.Return liver, spleen channel." Bencao Jingshu ": " Herba Verbenae is originally the medicine of removing heat from blood removing blood stasis.Bottom abscess person, the pole of heat in blood, furthermore damp and hot, therefore blood stains are turbid forms skin ulcer, and have worm also.The cool pyrolysis of blood, the broken and row of dirty person, waste and be not recovered.CHEN Zang-Qi calls its removing blood stasis parasite killing, also this meaning ear." " Japan hanako materia medica ": " logical menstruation, controls married woman's vim and vigour tripe swollen, and the moon waits irregular." venbenalin is in a small amount excited to SNE, suppress in a large number; Galactopoiesis can be promoted to mammal.Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema.For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, enters liver, the heart, spleen channel, " Treatise on Febrile Disease with Notes ": " the arteries and veins person house of blood, all blood all belongs to the heart, and all persons of promoting blood circulation must first reinforcing the heart benefit blood, therefore Zhang Zhongjing is controlled brothers and fainted cold, thready pulse being about to disappear person, by the hardship temperature of Radix Angelicae Sinensis to help painstaking effort." " book on Chinese herbal medicine is newly organized ": " Radix Angelicae Sinensis, sweet in the mouth is pungent, temperature, can rise and can fall, the YIN aspect of YANG, nontoxic.Though there is upper purgation to divide, enrich blood then one.Enter the heart, spleen, liver three are dirty.But its property is very dynamic, then QI invigorating in the Qi-tonifying drug entered, then enriches blood in the hematonic entered, without determining merit also." have to enrich blood and invigorate blood circulation, the effect of menstruction regulating and pain relieving, the relieving constipation of profit soup, for cards such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.1. oxygen lack resistant function; 2. conditioner body immunity function, there is antitumaous effect; 3. cosmetology effect; 4. to enrich blood the effect of invigorating blood circulation; 5. antibacterial, arteriosclerosis effect.Modern study shows, Radix Angelicae Sinensis has conditioner body immunity function, enriches blood and invigorate blood circulation, antibacterial effect of Denging.It can improve uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea, in addition, Radix Angelicae Sinensis can the immunity of enhancing body.
Radix vignae sinensis: sweet; Flat.Return spleen; Stomach warp.Invigorating the spleen and benefiting QI; Removing food stagnancy; Removing toxic substances.Main weakness of the spleen and stomach; Food stagnation; Leucorrhea; Stranguria with turbid discharge; Hemorrhoidal bleeding; Furuncle.
Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.The several amino acids of rich in starch and needed by human body, has the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, is applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the disease such as edema, beriberi, acute appendicitis, leucorrhea.
Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis): pungent, temperature.Wind-expelling pain-stopping, the spleen strengthening and damp drying, dissipating blood stasis for subsidence of swelling.Control cholera to vomit and diarrhoea, rheumatalgia, carbuncle scrofula.Expelling wind and removing dampness, regulating QI to relieve pain, hemostasis, dissipating blood stasis.Dispelling the wind and dampness pathogens osteodynia, stomachache, hemoptysis, spit blood, have blood in stool, metrorrhagia, abdominal pain in menstruation, puerperal abdominal pain due to blood stasis, traumatic injury.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Olibanum: acrid in the mouth; Bitter; Tepor.GUIXIN; Liver; Spleen channel.Blood-activating and qi-promoting; Inducing menstruation to relieve menalgia; Detumescence and promoting granulation.Main trusted subordinate's pain; Rheumatic arthralgia; Amenorrhea dysmenorrhea; Traumatic injury stasis of blood pain; Swollen ulcer drug; Intestinal carbuncle; The sore being festered and unhealed.
Caulis Sargentodoxae: bitter; Flat.Return liver; Large intestine channel.Removing toxicity for eliminating carbuncles; Promoting blood circulation and stopping pain; Expelling wind and removing dampness; Parasite killing.Main intestinal carbuncle; Dysentery; Mastalgia; Dysmenorrhea; Amenorrhea; Traumatic injury; Rheumatic arthralgia; Abdominal pain due to worm stagnation.
Rhizoma Begoniae Fimbristipulatae: sweet in the mouth, cool in nature.Clearing away heat and cooling blood; Relieving cough and resolving phlegm; Removing toxic substances and promoting subsidence of swelling.Main exogenous high fever; Heatstroke; Cough due to lung-heat; Laryngopharynx swelling and pain; Furuncle; Scrofula; Scabies; Burn and scald; Traumatic injury stasis of blood pain.1. " conventional Chinese herbal medicine color atlas ": pneumonia is coughed, spitting of blood, chronic bronchitis.2. " the practical Chinese herbal medicine in Guangxi newly selects ": removing heat from blood and promoting blood circulation, anti-inflammatory analgetic.Cure mainly spitting of blood, abdominal pain due to blood stasis, bruise, fracture, burn, tinea scabies.
Rhizoma Curcumae: acrid in the mouth; Bitter; Warm in nature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis; Removing food stagnancy pain relieving.Main vim and vigour are pained; Eating accumulation; Abdominal distention; Amenorrhea due to stagnation of blood; Dysmenorrhea; Lump in the abdomen tumor mass in the abdomen; Traumatic injury.
Herba youngiae japonicae: Compositae Youngia plant Herba youngiae japonicae is used as medicine with herb or root.Sweet, micro-hardship, cool.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, pain relieving.For pharyngitis, mastitis, toothache, dysuria, cirrhotic ascites; Furuncle toxic swelling is controlled in external.
Cortex Myricae Rubrae (Cortex Myricae Esculentae): be bark or the root bark of Myruca ceas vegetable hair Fructus Myricae rubrae.Antiinflammatory, convergence, antidiarrheal, upper blood, pain relieving, controls dysentery, enteritis, metrorrhagia, stomachache.
Radix Salviae Miltiorrhizae: bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments provide a kind of medicine being used for the treatment of cattle endometritis, be made up of the raw medicinal material of following parts by weight: Herba Sonchi Arvensis 13 weight portion, Herba Andrographis 22 weight portion, Herba hemipharagmatis heterophylli 15 weight portion, Radix Rumicis Patientiae 19 weight portion, Spora Lygodii 23 weight portion, Herba Gonostegiae hirtae 18 weight portion, Radix Serissae 9 weight portion, Herba Portulacae 22 weight portion, Herba Peperomiae Dindygulensis 14 weight portion, Herba Violae dissectae 11 weight portion, Radix Betae 19 weight portion, Lignum Sappan 15 weight portion, Fructus Liquidambaris 16 weight portion, Radix Lamiophlomidis Rotatae 8 weight portion, Semen Vaccariae 13 weight portion, Pheretima 9 weight portion, Herba Lycopi 13 weight portion, Cortex Moutan 11 weight portion, Huechys sanguinea De Geer. 12 weight portion, Flos Rosae Chinensis 21 weight portion, Herba Verbenae 18 weight portion, Olibanum 19 weight portion, Caulis Sargentodoxae 21 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae 23 weight portion, Radix vignae sinensis 17 weight portion, Semen Coicis 23 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15 weight portion and the Rhizoma Atractylodis Macrocephalae 21 weight portion.
Its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3cm, soak 6 hours; Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate a, for subsequent use; Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2cm, soaks 5 hours; Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 150ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Embodiment 2 pharmaceutical composition 2
Embodiments provide a kind of medicine being used for the treatment of cattle endometritis, be made up of the raw medicinal material of following parts by weight: Herba Sonchi Arvensis 13 weight portion, Herba Andrographis 22 weight portion, Herba hemipharagmatis heterophylli 15 weight portion, Radix Rumicis Patientiae 19 weight portion, Spora Lygodii 23 weight portion, Herba Gonostegiae hirtae 18 weight portion, Radix Serissae 9 weight portion, Herba Portulacae 22 weight portion, Herba Peperomiae Dindygulensis 14 weight portion, Herba Violae dissectae 11 weight portion, Radix Betae 19 weight portion, Lignum Sappan 15 weight portion, Fructus Liquidambaris 16 weight portion, Radix Lamiophlomidis Rotatae 8 weight portion, Semen Vaccariae 13 weight portion, Pheretima 9 weight portion, Herba Lycopi 13 weight portion, Cortex Moutan 11 weight portion, Huechys sanguinea De Geer. 12 weight portion, Flos Rosae Chinensis 21 weight portion, Herba Verbenae 18 weight portion, Olibanum 19 weight portion, Caulis Sargentodoxae 21 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae 23 weight portion, Radix vignae sinensis 17 weight portion, Semen Coicis 23 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15 weight portion, the Rhizoma Atractylodis Macrocephalae 21 weight portion, Rhizoma Begoniae Fimbristipulatae 17 weight portion, Rhizoma Curcumae 17 weight portion, Herba youngiae japonicae 18 weight portion, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13 weight portion and Radix Salviae Miltiorrhizae 23 weight portion.
Its preparation method is as follows:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
The toxicity test 1 of pharmaceutical composition:
1, trial drug
Choose Herba Sonchi Arvensis 13g, Herba Andrographis 22g, Herba hemipharagmatis heterophylli 15g, Radix Rumicis Patientiae 19g, Spora Lygodii 23g, Herba Gonostegiae hirtae 18g, Radix Serissae 9g, Herba Portulacae 22g, Herba Peperomiae Dindygulensis 14g, Herba Violae dissectae 11g, Radix Betae 19g, Lignum Sappan 15g, Fructus Liquidambaris 16g, Radix Lamiophlomidis Rotatae 8g, Semen Vaccariae 13g, Pheretima 9g, Herba Lycopi 13g, Cortex Moutan 11g, Huechys sanguinea De Geer. 12g, Flos Rosae Chinensis 21g, Herba Verbenae 18g, Olibanum 19g, Caulis Sargentodoxae 21g, Radix Angelicae Sinensis 25g, Radix Glycyrrhizae 23g, Radix vignae sinensis 17g, Semen Coicis 23g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15g and Rhizoma Atractylodis Macrocephalae 21g mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
The toxicity test 2 of pharmaceutical composition:
1, trial drug
Choose Herba Sonchi Arvensis 13g, Herba Andrographis 22g, Herba hemipharagmatis heterophylli 15g, Radix Rumicis Patientiae 19g, Spora Lygodii 23g, Herba Gonostegiae hirtae 18g, Radix Serissae 9g, Herba Portulacae 22g, Herba Peperomiae Dindygulensis 14g, Herba Violae dissectae 11g, Radix Betae 19g, Lignum Sappan 15g, Fructus Liquidambaris 16g, Radix Lamiophlomidis Rotatae 8g, Semen Vaccariae 13g, Pheretima 9g, Herba Lycopi 13g, Cortex Moutan 11g, Huechys sanguinea De Geer. 12g, Flos Rosae Chinensis 21g, Herba Verbenae 18g, Olibanum 19g, Caulis Sargentodoxae 21g, Radix Angelicae Sinensis 25g, Radix Glycyrrhizae 23g, Radix vignae sinensis 17g, Semen Coicis 23g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15g, Rhizoma Atractylodis Macrocephalae 21g, Rhizoma Begoniae Fimbristipulatae 17g, Rhizoma Curcumae 17g, Herba youngiae japonicae 18g, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13g and Radix Salviae Miltiorrhizae 23g mixes, be ground into powder, added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue, again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate, merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
Shandong Province's veterinary station, in March ,-2013 in February, 2012, sees and treat patients 185 and suffers from the sick cattle of cattle endometritis, course of disease 8-50 days.Suffer from cattle haunch, lift tail, sometimes exert duty, frequently flow out a large amount of brown color mucus purulent secretion from vagina, have be also mingled with the blood streak, matter thickness has smelly dirty taste, include floccule or afterbirth fragment, often adhere to root of the tail, form dry crusts, the high heat of companion, shiver with cold, inappetence, oliguria with reddish urine, constipation.Examination per rectum, cornua uteri is thicker, and Uterus wall thickens.Be diagnosed as cattle endometritis disease.
Choose 90 ill cattle, be divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, three groups in body weight, the state of an illness etc. all without significant difference, there is comparability.Embodiment group 1, embodiment group 2 and matched group use the injectable powder of the decoction of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively.Wherein, decoction adopt brown sugar water gavage, each 0.5mg/kg, every day secondary; Injectable powder adopts intramuscular injection, each 0.6mg/kg, once a day, uses 7 days continuously; Conventional medicament adopts penicillin 2,400,000 unit, streptomycin 1,000,000 unit is dissolved in uterine perfusion in 30ml normal saline, once a day.Experimental period is 7 days, and result is as shown in table 1.Wherein, curative effect determinate standard: clinical symptom disappearance after medication, uterus function recovers normal, and secretions is normal, is judged to recovery from illness; Symptom obviously alleviates, and is judged to effectively; Symptom is even dead without improvement, and it is invalid to be judged to.
The therapeutic effect synopsis of table 1 three experimental group cattle
Group Sum Recovery from illness number Significant figure Invalid number Total effective rate
Embodiment group 1 30 25 4 1 96.7%
Embodiment group 2 30 27 3 0 100%
Matched group 30 12 11 7 76.7%
Data from table 1: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has determined curative effect, rapid-action, evident in efficacy, cheap, the advantage that has no side effect in treatment cattle endometritis.
Simultaneously to recovery from illness and the effective trouble Niu Jinhang tracking of three groups of experimental grouies, after treatment, the situation of the becoming pregnant statistics of milch cow is as follows:
Embodiment group 1 is fully recovered and effective is suffered from cattle 29, wherein, 25 of recovery from illness, become pregnant 25, effective 4, become pregnant 3, after treatment, pregnancy rate is 96.6%;
Embodiment group 2 is fully recovered and effective is suffered from cattle 30, wherein, 27 of recovery from illness, become pregnant 27, effective 3, become pregnant 3, after treatment, pregnancy rate is 100%;
Matched group recovery from illness and effective suffer from cattle 23, wherein, 12 of recovery from illness, become pregnant 11, effective 11, become pregnant 8, after treatment, pregnancy rate is 82.6%.
Known by above data, the medicine of the embodiment of the present invention 1 and 2, while treatment cattle endometritis, improves the pregnancy rate of the rear ill cattle for the treatment of.
Model case
There is cattle haunch, lift tail in farm, Binzhou, Shandong milch cow 10 of seeing and treating patients in March, 2012, sometimes duty is exerted, frequently flow out a large amount of brown color mucus purulent secretion from vagina, have be also mingled with the blood streak, matter thickness has smelly dirty taste, include floccule or afterbirth fragment, normal attachment root of the tail, forms dry crusts, the high heat of companion, shiver with cold, inappetence, oliguria with reddish urine, constipation.Examination per rectum, cornua uteri is thicker, and Uterus wall thickens.Be diagnosed as cattle endometritis disease.Gavage the decoction of the embodiment of the present invention 1 immediately, each 0.5mg/kg, every day secondary, after 4 days, sick cattle secretions starts normally, and symptom is obviously improved, the 5th day recovery from illness 8, the 6th day residue 2 recoveries from illness.Follow up a case by regular visits to all after 2 years normal, 10 cattle are all normally become pregnant.
In November, 2012 there is cattle haunch, lifts tail in the cattle 26 of Distributions in Liaocheng of Shandong Province farmer breed, frequently flow out a large amount of brown color mucus purulent secretion from vagina, have be also mingled with the blood streak, matter thickness has smelly dirty taste, include floccule or afterbirth fragment, normal attachment root of the tail, form dry crusts, the high heat of companion, shiver with cold, inappetence, oliguria with reddish urine, constipation.Examination per rectum, cornua uteri is thicker, and Uterus wall thickens.Be diagnosed as cattle endometritis disease.Inject the injectable powder of the embodiment of the present invention 2 immediately, each 0.6mg/kg, once a day.After 3 days, sick cattle secretions starts normally, and symptom is obviously improved, recovery from illness in the 5th day 23,3 recoveries from illness of the 6th day residue.Follow up a case by regular visits to all after 2 years normal, 26 cattle are all normally become pregnant.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. be used for the treatment of the medicine of cattle endometritis, it is characterized in that, described medicine comprises following raw medicinal material: Herba Sonchi Arvensis, Herba Andrographis, Herba hemipharagmatis heterophylli, Radix Rumicis Patientiae, Spora Lygodii, Herba Gonostegiae hirtae, Radix Serissae, Herba Portulacae, Herba Peperomiae Dindygulensis, Herba Violae dissectae, Radix Betae, Lignum Sappan, Fructus Liquidambaris, Radix Lamiophlomidis Rotatae, Semen Vaccariae, Pheretima, Herba Lycopi, Cortex Moutan, Huechys sanguinea De Geer., Flos Rosae Chinensis, Herba Verbenae, Olibanum, Caulis Sargentodoxae, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix vignae sinensis, Semen Coicis, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) and the Rhizoma Atractylodis Macrocephalae.
2. the medicine being used for the treatment of cattle endometritis according to claim 1, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Sonchi Arvensis 10-15 weight portion, Herba Andrographis 20-26 weight portion, Herba hemipharagmatis heterophylli 13-18 weight portion, Radix Rumicis Patientiae 16-22 weight portion, Spora Lygodii 21-27 weight portion, Herba Gonostegiae hirtae 15-25 weight portion, Radix Serissae 8-15 weight portion, Herba Portulacae 21-28 weight portion, Herba Peperomiae Dindygulensis 13-18 weight portion, Herba Violae dissectae 10-16 weight portion, Radix Betae 15-26 weight portion, Lignum Sappan 10-16 weight portion, Fructus Liquidambaris 13-18 weight portion, Radix Lamiophlomidis Rotatae 6-9 weight portion, Semen Vaccariae 10-17 weight portion, Pheretima 8-12 weight portion, Herba Lycopi 12-18 weight portion, Cortex Moutan 8-14 weight portion, Huechys sanguinea De Geer. 10-16 weight portion, Flos Rosae Chinensis 15-26 weight portion, Herba Verbenae 10-22 weight portion, Olibanum 18-23 weight portion, Caulis Sargentodoxae 11-22 weight portion, Radix Angelicae Sinensis 22-28 weight portion, Radix Glycyrrhizae 15-26 weight portion, Radix vignae sinensis 15-19 weight portion, Semen Coicis 21-29 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10-18 weight portion and Rhizoma Atractylodis Macrocephalae 13-24 weight portion.
3. the medicine being used for the treatment of cattle endometritis according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Sonchi Arvensis 13 weight portion, Herba Andrographis 22 weight portion, Herba hemipharagmatis heterophylli 15 weight portion, Radix Rumicis Patientiae 19 weight portion, Spora Lygodii 23 weight portion, Herba Gonostegiae hirtae 18 weight portion, Radix Serissae 9 weight portion, Herba Portulacae 22 weight portion, Herba Peperomiae Dindygulensis 14 weight portion, Herba Violae dissectae 11 weight portion, Radix Betae 19 weight portion, Lignum Sappan 15 weight portion, Fructus Liquidambaris 16 weight portion, Radix Lamiophlomidis Rotatae 8 weight portion, Semen Vaccariae 13 weight portion, Pheretima 9 weight portion, Herba Lycopi 13 weight portion, Cortex Moutan 11 weight portion, Huechys sanguinea De Geer. 12 weight portion, Flos Rosae Chinensis 21 weight portion, Herba Verbenae 18 weight portion, Olibanum 19 weight portion, Caulis Sargentodoxae 21 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae 23 weight portion, Radix vignae sinensis 17 weight portion, Semen Coicis 23 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15 weight portion and the Rhizoma Atractylodis Macrocephalae 21 weight portion.
4. the medicine being used for the treatment of cattle endometritis according to any one of claim 1-3, is characterized in that, described medicine is bag Rhizoma Begoniae Fimbristipulatae, Rhizoma Curcumae, Herba youngiae japonicae, Cortex Myricae Rubrae (Cortex Myricae Esculentae) and Radix Salviae Miltiorrhizae also.
5. the medicine being used for the treatment of cattle endometritis according to any one of claim 1-4, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Sonchi Arvensis 10-15 weight portion, Herba Andrographis 20-26 weight portion, Herba hemipharagmatis heterophylli 13-18 weight portion, Radix Rumicis Patientiae 16-22 weight portion, Spora Lygodii 21-27 weight portion, Herba Gonostegiae hirtae 15-25 weight portion, Radix Serissae 8-15 weight portion, Herba Portulacae 21-28 weight portion, Herba Peperomiae Dindygulensis 13-18 weight portion, Herba Violae dissectae 10-16 weight portion, Radix Betae 15-26 weight portion, Lignum Sappan 10-16 weight portion, Fructus Liquidambaris 13-18 weight portion, Radix Lamiophlomidis Rotatae 6-9 weight portion, Semen Vaccariae 10-17 weight portion, Pheretima 8-12 weight portion, Herba Lycopi 12-18 weight portion, Cortex Moutan 8-14 weight portion, Huechys sanguinea De Geer. 10-16 weight portion, Flos Rosae Chinensis 15-26 weight portion, Herba Verbenae 10-22 weight portion, Olibanum 18-23 weight portion, Caulis Sargentodoxae 11-22 weight portion, Radix Angelicae Sinensis 22-28 weight portion, Radix Glycyrrhizae 15-26 weight portion, Radix vignae sinensis 15-19 weight portion, Semen Coicis 21-29 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 10-18 weight portion and Rhizoma Atractylodis Macrocephalae 13-24 weight portion, Rhizoma Begoniae Fimbristipulatae 11-19 weight portion, Rhizoma Curcumae 15-23 weight portion, Herba youngiae japonicae 10-19 weight portion, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 12-19 weight portion and Radix Salviae Miltiorrhizae 21-26 weight portion.
6. the medicine being used for the treatment of cattle endometritis according to any one of claim 1-5, is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Herba Sonchi Arvensis 13 weight portion, Herba Andrographis 22 weight portion, Herba hemipharagmatis heterophylli 15 weight portion, Radix Rumicis Patientiae 19 weight portion, Spora Lygodii 23 weight portion, Herba Gonostegiae hirtae 18 weight portion, Radix Serissae 9 weight portion, Herba Portulacae 22 weight portion, Herba Peperomiae Dindygulensis 14 weight portion, Herba Violae dissectae 11 weight portion, Radix Betae 19 weight portion, Lignum Sappan 15 weight portion, Fructus Liquidambaris 16 weight portion, Radix Lamiophlomidis Rotatae 8 weight portion, Semen Vaccariae 13 weight portion, Pheretima 9 weight portion, Herba Lycopi 13 weight portion, Cortex Moutan 11 weight portion, Huechys sanguinea De Geer. 12 weight portion, Flos Rosae Chinensis 21 weight portion, Herba Verbenae 18 weight portion, Olibanum 19 weight portion, Caulis Sargentodoxae 21 weight portion, Radix Angelicae Sinensis 25 weight portion, Radix Glycyrrhizae 23 weight portion, Radix vignae sinensis 17 weight portion, Semen Coicis 23 weight portion, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 15 weight portion, the Rhizoma Atractylodis Macrocephalae 21 weight portion, Rhizoma Begoniae Fimbristipulatae 17 weight portion, Rhizoma Curcumae 17 weight portion, Herba youngiae japonicae 18 weight portion, Cortex Myricae Rubrae (Cortex Myricae Esculentae) 13 weight portion and Radix Salviae Miltiorrhizae 23 weight portion.
7. the medicine being used for the treatment of cattle endometritis according to any one of claim 1-6, is characterized in that, the dosage form of described medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. the medicine being used for the treatment of cattle endometritis according to any one of claim 1-6, is characterized in that, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour; Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use; Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour; Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
9. the preparation method being used for the treatment of the medicine of cattle endometritis as described in any one of claim 1-6, is characterized in that, the dosage form of described medicine is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
10. the preparation method being used for the treatment of the medicine of cattle endometritis as described in any one of claim 1-6, is characterized in that, the dosage form of described medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour; Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use; Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour; Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
CN201510878215.8A 2015-12-04 2015-12-04 Medicine for treating cow endometritis and preparation method thereof Pending CN105412695A (en)

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CN105853960A (en) * 2016-04-12 2016-08-17 董雅娟 Preparation for improving conception rate of cows, and method for improving conception rate of cows

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