Background technology
Cow in perinatal period typically refers to antenatal 21 days of milk cow to 21 days postpartum, and antenatal 21 days is pre-perinatal, and 21 days postpartum is for enclosing post-partum period.The milk cow experience is from the variation of physiology, endocrine, daily ration and external environment during this period, and this Nutrition and Metabolism to milk cow perinatal period, neuroendocrine, immune system all produce certain influence, make milk cow various metabolic diseases very easily occur in postpartum.People often more pay attention to the nutrition and the management of milking cow in the actual production, have ignored the concern to milk cow perinatal period, make cows in postpartum the phenomenon of various metabolic diseases and breeding difficulty occur, have had a strong impact on the economic benefit of dairy.Therefore study generation, have great importance for the general level of the health that guarantees milk cow and raising production performance through nutrition regulation measure control cow in perinatal period various diseases.Perinatal period, the physiological change characteristic of milk cow mainly contained:
(1) endocrine variation
Milk cow gets into third trimester of pregnancy; Endocrinosity takes place obviously to change, thereby is that childbirth and lactation are ready, and plasma insulin level descends in third trimester of pregnancy and lactation in early days; And level of growth hormone raises, and these two kinds of hormonal readinesses take place significantly to go up and down to change during childbirth.Estrogen level in the blood plasma raise in third trimester of pregnancy, but childbirth the time descends at once, and plasma progesterone concentration higherly is beneficial to keep gestation in the dry milk phase, and a few days ago descends rapidly in childbirth.The concentration of glucocorticoid and prolactin rose in childbirth the same day, and childbirth finishes the back and returned to original level in about one day again.Parathyroid hormone and 1, the secretion of 25-dihydroxy vitamin D increases, and especially suffers from more obvious that the serious milk cow that hangs down blood calcium raises.
(2) variation of dry matter intake (DMI)
In former weeks of milk cow calving, fetus and placenta reach maximum to the requirement of nutrition, and the DMI intake is compared in earlier stage with dry milk and reduced 10%-30%.Childbirth closes on, and fetus is caused slowing down of gastrointestinal peristalsis to the compressing aggravation in abdominal cavity, is one of reason that causes the reduction of DMI intake.Newborn heat symptom-complex that perinatal period, metabolic disorder caused and subclinical newborn heat symptom-complex reduce blood calcium concentration, cause the muscle tone forfeiture, and then influence gastrointestinal peristalsis function and chyme through gastral velocity of liquid assets, and this also can reduce DMI (Goff and Horst, 1997).The variation of daily ration composition and nutrient composition content also influences antenatal DMI before and after the childbirth.Milk cow dry absorption minimizing is accumulated with fetus increase and abdominal cavity fat and is caused mechanicalness compressing cud relevant also relevant with reproductive hormone.Plasma progesterone content descends and estrogenic content still remains on higher level or reality increases to some extent before the childbirth, and higher estrogen level is considered to reduce the principal element (Grummer, 1993) of DMI in the blood plasma before and after calving.
(3) variation of energetic supersession
Milk cow perinatal period DMI sharply reduce, cause the metabolism generation obvious variation of each histoorgan of milk cow perinatal period.The glucose that the cattle liver of suckling perinatal period utilizes propionic acid to generate; When lactation, utilized synthetic lactose by milk cow mostly; And milk cow is in the lactation period in postpartum; The lactose of secreting in milk is a lot, and these lactose are to be changed by glucose to form, so the requirement of glucose (galactopoiesis every day 20kg just needs glucose 1.24kg) very greatly.Under the normal condition, 50% the glucose of having an appointment is from propionic acid.And the propionic acid that perinatal milk cow makes generation because of DMI descends is not enough, finally causes glycogen heteroplasia obstacle.This is the one of the main reasons that the milk cow negative energy balance takes place.
Another function of propionic acid is to participate in the fat metabolism of milk cow, and when the energy demand of cow producing milk surpassed its energy of eating, milk cow just began to employ body fat, and fat at first is broken down into non-esterified fatty acid (NEFA), and is transported to liver.At liver, NEFA is broken down into acetate, and the acetate of generation thoroughly is decomposed into carbon dioxide and water with the generation more energy, but this process need propionic acid; Perinatal period, milk cow did not have enough propionic acid to be utilized because of DMI reduces; Too much acetate will be assembled in liver; Molecular acid can be converted into acetone, acetoacetate and beta-hydroxybutyric acid (BHBA) under the effect of enzyme; These products get in blood, accumulate certain level and cause the ketoacidosis symptom, thereby can increase the weight of the negative balance of energy.
(4) variation of protein and amino acid metabolism
In third trimester of pregnancy, because being converted into clean protein efficiency ratio, PER, growth rate, breast tissue composition and the metabolizable protein of mammary gland parenchymal tissue increase, if satisfy the growth needs of mammary gland parenchymal tissue perinatal period, protein level will improve in the daily ration.Pre-perinatal daily ration crude protein was respectively 10.5%, 12.6%, 14.5% o'clock, and milk cow all is in positive nitrogen equilibrium, the daily ration of the same protein of feeding postpartum, and the performance of giving milk is also similar.Adding limiting amino acid maybe be more effective than improving crude protein total amount or by-pass protein.
In one week of postpartum of giving a birth, the amino acid whose requirement of milk cow the negative balance of protein generally occurs far above amino acid whose relative quantity delivered in one week of postpartum.Amino acid whose source mainly is a skeletal muscle, organizes the albumen of net loss to make the diameter of bone fiber reduce about 25% from these after the milk cow calving.Glutamine is the synthetic amino acid of restriction lactoprotein, also is simultaneously the material of the synthesis of glucose tolerance factor and the source of enteron aisle energy, is to keep the normal key substance of immunologic function.
(5) variation of calcium metabolism
It is very accurate keeping the constant regulation mechanism of blood calcium concentration in the milk cow body, but perinatal period this balance broken.This is because milk cow is very limited to the metabolism of calcium at first half period of gestation, is mainly used in fetal growth and through defecate, loses the endogenous calcium of about 10g-12g every day; Therefore need not replenish more calcium; But in the childbirth and the process of giving milk, the metabolism of calcium is very fast, causes the calcium metabolism imbalance.Because initiation of lactation, sharply increase the demand of calcium, so the calcium quantity that gets into mammary gland from extracellular fluid surpasses the quantity that heavily absorbs calcium through intestinal absorption and bone.The calcium content of colostrum is 2.3g/L, and the milk cow that once produces the 10L colostrum will lose 23g calcium, is equivalent to 9 times of cow head blood calcium reserves.Employing of blood calcium deposit, absorption that must be through increasing enteron aisle calcium and bone calcium employ additional.Therefore after calving a few days ago because intestinal absorption and bone are mobilized and machine-processedly be not ready to supply with the required calcium of lactation fully, low blood calcium in various degree all can appear in about 67% milk cow.Because a large amount of calcium are secreted in the milk, cause the rapid decline of extracellular and plasma calcium concentration, and then show the clinical or inferior clinical symptom of milk fever.It is individual that the paralysis symptom appears in cows in postpartum, and the ratio of suffering from other metabolic diseases is 3-9 a times of normal milk cow.
(7) variation of immunity function
Perinatal period milk cow experience physiology and metabolism stress; Cause the acute deficiency that guarantees the normal nutriment of milk cow function of immune system; The milk cow immunologic function is suppressed; Reduce the resistivity of milk cow to various diseases, this possibly be a milk cow environment property mammitis and the higher reason of hysteritis incidence of disease perinatal period.Early stage energy of lactation and metabolism imbalance have been damaged functions of immune system, and blood ketoboidies level raises and brings out ketoacidosis, further damages lymphatic system and central nervous system, thereby has increased the neurological susceptibility of milk cow to mammitis.The immune response to external world of milk cow perinatal period reduces, and changes nonspecific immune reaction, comprises the function that reduces neutrophil cell, reduces lymphopoietic quantity, reduces antibody quantity and plasmacytic generation.
(8) postpartum breeding function variation
Time in calving interval and to divide required time of recovering normally to oestrus in puerperium be an important indicator estimating cow reproduction power quality; Should be able to observe estrus of cow general the branch in 60 days puerperiums; Yet morbidity during childbirth, for example difficult labour, retained afterbirth, hysteritis and the metabolic disorder of lactation early nutrition; Like milk fever, fat syndrome and ketoacidosis etc. is the main cause that delay is oestrused, and therefore reducing the childbirth complication to greatest extent has great help to improving whole milk cows reproductive capacity.Ovary is main organ of multiplication, and it is the organ of follicular development and ovulation, justacrine estrogen and progesterone.A certain amount of estrogen is the direct factor of estrus of cow, and corpus luteum can be secreted progesterone, and it is to keep one of conceived necessary hormone, and cow ovary in postpartum functional recovery is normal, and conception rate is high, and the nonpregnant time is short; The ovary functional recovery is slow, and conception rate obviously descends, nonpregnant time lengthening.Divide the puerperium, the milk cattle uterus returns to pregravidic state and function from various variations conceived and that childbirth is taken place, returns to the past in the whistle palace.Under the normal condition, the state when uterus, 40 days left and right sides returns to unpregnancy basically behind the cow birth if this process prolongs, just is called the atony of uterus or the subinvolution of uterus.The milk cow involution of uterus influences the production performance of reproductive capacity in postpartum, calving interval and cows in postpartum, and the reproduction function of recovering cows in postpartum as early as possible is significant to the economic benefit that improves milk cow production.
Summary of the invention
An object of the present invention is to disclose a kind of perinatal period of milk cow special nutritional control additive.
Another object of the present invention is the method for using that discloses milk cow special nutritional control additive perinatal period.
A further object of the present invention is to disclose milk cow special nutritional control additive preparation improvement perinatal period cows in postpartum negative energy balance state, the application of aspects such as promotion body condition recovery.
For realizing above-mentioned purpose, the invention discloses following technology contents:
A kind of perinatal period milk cow special nutritional control additive, it is characterized in that per kilogram is made up of following raw material:
Rumen-undegraded fat 300-400g/kg
Vitamin A 50-60 ten thousand IU
Vitamin E 5000-6000IU
Selenium 3-5mg/kg
Compound Chinese herb 100-200g/kg
All the other are carrier silica;
Wherein said compound Chinese herb by percetage by weight is: 10% Radix Astragali, 10% Radix Codonopsis, 5% rhizoma cyperi, 5% bighead atractylodes rhizome, 10% Radix Angelicae Sinensis, 10% root of herbaceous peony, 10% cultivated land, 10% barrenwort, 10% play both sides of the street, 10% seed of cowherb, 10% motherwort are pulverized mixed preparing and formed.
The present invention further discloses the method for using of milk cow special nutritional control additive perinatal period, it is to bring into use in antenatal 30 days from milk cow, finishes to 30 days postpartum, and addition is 100-200g/ (a d head).
The present invention also discloses simultaneously perinatal period milk cow special nutritional control additive and existed: milk cow immunity perinatal period is regulated in (1)
Function improves premunition, reduces the application of cows in postpartum mammitis, endometritis, ketoacidosis, puerperal fever disease aspect.(2) improve milk cow negative energy balance state, promote the application of cows in postpartum body condition recovery aspect.(3) promote cows in postpartum to oestrus, improve the application of reproductive performance aspect.
It is long chain fatty acid calcium salt (99% calcium palmitate and 1% antioxidant BHT) that rumen-undegraded fat of the present invention refers to main component, has commercially available.
Selenium of the present invention refers to a kind of trace selenium element to be added with the form of sodium selenite.
Perinatal period of the present invention milk cow special nutritional control additive the preparation method:
(1) various Chinese herbal medicines are pulverized, mixed then, subsequent use.
(2) with the compound Chinese medicinal herbs after rumen-undegraded fat, vitamin A, vitamin E, sodium selenite, the pulverizing and silica mixing in proportion, promptly get.
Perinatal period, the dairy cow nutrition regulation measure comprised:
(1) improves cows in postpartum feed intake perinatal period
The milk cow daily ingestion amount is the basis of daily ration design, and it has determined whether the energy through the feed supply milk cow can satisfy it with other nutriments and kept physiology, growth and production needs every day.Add flavor enhancement and can effectively increase the voluntary feed intake of milk cow, improve cows in postpartum dry matter intake perinatal period.
(2) suitably increase dietary digestibility of energy concentration
Suitably increasing the especially rumen-undegraded fat and the content of crossing cud starch (or glucose) in the beneficiated burden material complemental feed of dietary digestibility of energy concentration, is the good approach that effectively improves dairy cow diet net energy level.
(3) pre-perinatal interpolation anion salt is regulated the milk cow calcium metabolism
Daily ration anion-cation balance (DCAD) is meant main cation (Na in the dairy cow diet
+, K
+, Ca
2+, Mg
2+) and main anion (Cl
-, S
2-, PO
4 3-) content and mM number (mmol) thereof poor.When DCAD on the occasion of the time be called cationic daily ration, be called the anionic daily ration during for negative value.Daily ration DCAD directly influences the electrolyte balance of milk cow alimentary canal and body.DCAD changes, and osmotic pressure, acid-base balance, water-electrolyte metabolism and physiological and biochemical index in the milk cow body all can change.At milk cow dry milk later stage (promptly pre-perinatal) the anionic daily ration of feeding, inducing cows body fluid is subacute metabolic acidity and rises, and helps the absorption of calcium ion and improves the blood calcium concentration, prevents the generation of milk fever.Since most of feedstuff DCAD be on the occasion of or near 0 value, so can in daily ration, add the purpose that anion salt reaches reduction daily ration DCAD.
(4) add immunomodulator and regulate the milk cow immunologic function, promote recover postpartum
Metabolic disorder takes place cow in perinatal period easily stimulates the oxidative stress due to waiting relevant with latter half of gestation and childbirth.Selenium and vitamin E are all participated in the anti-oxidative defense system of body, have synergy between them.In recent years, people further investigate the importance of vitamin E in milk cow produces, and think to play a significant role at the aspects such as generation of anti-oxidant, as to regulate body immune response, minimizing perinatal period disease.Selenium is the essential a kind of trace nutrient of animal, is bringing into play the various biological effect in vivo, yet, the anti-oxidation function of selenium most importantly wherein.Replenishing vitamins E and selenium can reduce the incidence of disease of mammitis, retention of afterbirth in dairy cow diet.
The main active substances retinoic acid of vitamin A and retinol can promote the synthetic of immunoglobulin (Ig), also can stimulate polymorphonuclear granulocyte to produce a large amount of superoxides, thereby strengthen its sterilizing power.Vitamin A is participated in the cellular immunity process, and it can strengthen the antigentic specificity reaction of cell, changes the stability of cell membrane and immunocyte mycoderm, improves immunocompetence, has anti-infectious function (Li Tingxin etc., 2005).Replenishing vitamins A can strengthen the immunity function of milk cow in dairy cow diet, improves premunition.
A lot of researchs show that Chinese herb feed additive has antibiotic, antibacterial, promotion lymphocyte transformation; Strengthen the phagocytic function of macrophage, improve cellular immunity and humoral immunity level, regulate the immunity of body; Strengthen resistance against diseases, important function such as control recessive mastitis.Simultaneously, use Chinese herb feed additive regulation and control milk cow reproductive endocrine function, the treatment uterine disease is oestrused to impel cows in postpartum fast, promotes follicular development, ovulates, is impregnated, gestation obtained obvious effects.In dairy cow diet, use Chinese herb feed additive can improve the immunologic function of milk cow, promote cows in postpartum to recover, improve the cow reproduction function.
Chinese herb astragalus, Radix Codonopsis, rhizoma cyperi, Radix Angelicae Sinensis, the bighead atractylodes rhizome, the root of herbaceous peony that the present invention selects have antibiotic, antiviral, anti-stress effect, can the non-specific and specific immune function of enhancing body, improve premunition; Simultaneously can tonifying middle-Jiao and Qi, strengthening the spleen and stomach improves appetite.The seed of cowherb and the coupling that plays both sides of the street have activating blood to promote menstruation, and swelling and pain relieving expedites the emergence of the function of lactogenesis.Motherwort, promoting blood circulation and removing blood stasis, the difficult labour of treatment threatened abortion, retention of afterbirth.Cultivated land, the lean marrow is mended in the enriching yin of enriching blood.
Barrenwort, the kidney tonifying clearing damp, it is cold infertile to control the palace.Generally speaking Chinese medicine preparation has following function:
(1) promoting blood circulation and removing blood stasis, improve the cow blood circulation.
(2) strengthening the spleen and stomach improves milk cow appetite.
(3) immunologic function of adjusting milk cow improves premunition.
(4) promote cows in postpartum to oestrus, improve reproductive performance.
The present invention finds through experimental study: the method for using of the nutrition regulation additive that milk cow perinatal period of being developed is special-purpose, generally brought into use in antenatal 30 days from milk cow, and finished to 30 days postpartum.Addition is 100-200g/ (a d head).
For the good effect of the present invention of explanation further, following test is provided:
1. the composition of per kilogram nutrition regulation additive: rumen-undegraded fat 300-400g/kg, vitamin A 50-60 ten thousand IU, vitamin E 5000-6000IU, selenium 3-5mg/kg, compound Chinese herb 100-200g/kg, all the other are carrier (silica).
Chinese herbal medicine is that pharmacy buys, and said compound Chinese herb by percetage by weight is: 10% Radix Astragali, 10% Radix Codonopsis, 5% rhizoma cyperi, 5% bighead atractylodes rhizome, 10% Radix Angelicae Sinensis, 10% root of herbaceous peony, 10% cultivated land, 10% barrenwort, 10% play both sides of the street, 10% seed of cowherb, 10% motherwort mixed preparing form.
2, the result of use of nutrition regulation additive:
2.1 add of the influence of 200 g/ (d head) nutrition regulation additive in the milk cow TMR daily ration in perinatal period to the body condition scoring of milk cow
The standard of table 1 milk cow five position body condition scorings
Table 2 nutrition regulation additive is to the influence of milk cow body condition scoring
Explanation is added 200 g/ (d head) and is added the nutrition regulation additive scoring has the trend of raising to the milk cow body condition in perinatal period milk cow TMR daily ration, can improve the body condition of milk cow.
2.2 add the influence of 200 g/ (d head) in the milk cow TMR daily ration in perinatal period to the milk cow energy balance
Table 3 nutrition regulation additive is to the influence of milk cow blood plasma energetic supersession product
The energy balance of milk cow can be estimated through measuring blood plasma associated metabolic product.Result of the test shows; Add the nutrition regulation additive and can improve the concentration of glucose in milk cow blood plasma perinatal period, reduce the concentration of free fatty and beta-hydroxybutyric acid, show that the satisfaction degree of glucose in the milk cow body improves; The degree of decomposition of body fat reduces, and it is less that milk cow is employed body fat.The concentration of free aliphatic acid and beta-hydroxybutyric acid is lower than the critical value (free fatty 500 μ Eq/L, beta-hydroxybutyric acid 1200 μ mol/mL) that clinical ketoacidosis is diagnosed in the milk cow blood plasma in postpartum simultaneously.Promptly use the special-purpose nutrition regulation additive of milk cow perinatal period can prevent the generation of milk cow negative energy balance.
2.3 add 200 g/ (d head) to the milk cow Immune Effects in the milk cow TMR daily ration in perinatal period
Table 4 nutrition regulation additive is to the influence of cow serum immunoglobulin content perinatal period
The content of Immunoglobulin IgA, IgM, IgG is the important indicator of judging the milk cow humoral immunity level in the cow serum.Can be known that by result of the test cow birth stress cause serum immune globulin IgA, IgM, IgG content sharply to descend, humoral immune function is suppressed.The content of 1 week, the childbirth same day and branch all serum IgAs of puerperium 1, IgM, IgG strengthens humoral immune function before using special-purpose nutrition regulation additive to increase cow birth in the dairy cow diet perinatal period.
Table 5 nutrition regulation additive is to the influence of milk cow blood plasma T-cell subsets perinatal period
T lymphocyte subset crowd stable is that to keep the normal immunoloregulation function of body necessary.CD4
+/ CD8
+Ratio is high, shows that body is in high immune level, works as CD4
+/ CD8
+When out of proportion, explain that there is defective in the body cell immunologic function, can cause various immunological diseases to take place.
Can know by result of the test, use special-purpose nutrition regulation additive can improve t lymphocyte subset crowd CD4 in the dairy cow diet in perinatal period
+, CD8
+Content and CD4
+/ CD8
+Ratio, can strengthen the milk cow cellular immune function, help to improve the resistance of milk cow for various diseases.
2.4 add 200 g/ (d head) to the cow reproduction Effect on Performance in the milk cow TMR daily ration in perinatal period
Table 6 nutrition regulation additive is to cow reproduction Effect on Performance perinatal period
Result of the test shows that use milk cow special nutritional control additive perinatal period can shorten the time that cows in postpartum is oestrused for the first time, improves the conception rate of the first feelings phase of postpartum milk cow, increases the ratio of oestrusing of milk cow colony in postpartum, improves the reproductive performance of milk cow.
2.5 add the influence of 200 g/ (d head) in the milk cow TMR daily ration in perinatal period to postpartum disease of cow
Table 7 nutrition regulation additive is to the influence of postpartum disease of cow generation perinatal period
Result of the test shows, adds the special-purpose nutrition regulation additive of milk cow perinatal period and can reduce disease incidence rate such as cows in postpartum mammitis, endometritis, ketoacidosis, puerperal fever and retention of afterbirth, improves the health status of milk cow.
The prescription of milk cow basal diet:
Table 8 milk cow perinatal period basal diet is formed and trophic level
Every kilogram of daily ration contains: vitamin A 3800 IU; Vitamin D
31200 IU; Vitamin E 30 IU; Iron 50 mg; Copper 10 mg; Zinc 40 mg; Manganese 40 mg; Iodine 0.5 mg; Selenium 0.3mg; Cobalt 0.1mg; Net energy for lactating cow is formed the calculating gained according to raw material, and all the other are measured value.
The good effect that perinatal period disclosed by the invention, milk cow special nutritional control additive was compared with prior art had is:
special nutritional control additive of the present invention is high in technological content; Comprehensive nutrition, equilibrium, be rich in the required various nutritional labelings of milk cow perinatal period; Increased dietary digestibility of energy concentration; Prevent milk cow generation negative energy balance, promoted the cows in postpartum body condition to recover;
special nutritional control additive of the present invention has strengthened the immunologic function of milk cow, improves premunition;
special nutritional control additive of the present invention has promoted the cows in postpartum recovery; Improve reproductive performance, can reduce the generation of diseases such as cows in postpartum mammitis, endometritis, ketoacidosis, puerperal fever.
The specific embodiment
Through following examples the present invention is described further, but not as restriction of the present invention.Parts by weight raw material described in the embodiments of the invention refers to gram, kilogram or ton, can adjust according to producing actual needs.Vitamin A wherein, vitamin E, rumen-undegraded fat, selenium element, silica, various Chinese herbal medicines etc. all have commercially available.
Embodiment 1
Perinatal period, the milk cow additive formulations was formed (preparing 1 kg):
Rumen-undegraded fat 300/kg
Vitamin A 500,000 IU
Vitamin E 5000IU
Selenium 3mg/kg
Compound Chinese herb 100g/kg
All the other are carrier silica;
Said compound Chinese herb material by percetage by weight is: 10% Radix Astragali, 10% Radix Codonopsis, 5% rhizoma cyperi, 5% bighead atractylodes rhizome, 10% Radix Angelicae Sinensis, 10% root of herbaceous peony, 10% cultivated land, 10% barrenwort, 10% play both sides of the street, 10% seed of cowherb, 10% motherwort are pulverized mixed preparing and formed.
The preparation method:
(1) ratio is pulverized various Chinese herbal medicines, mix then, subsequent use.
(2) with the compound Chinese herbal medicine after rumen-undegraded fat, vitamin A, vitamin E, sodium selenite, the pulverizing and silica mixing in proportion, can use.
Embodiment 2
Perinatal period, the milk cow additive formulations was formed (preparing 1 kg):
Rumen-undegraded fat 400g/kg
Vitamin A 600,000 IU
Vitamin E 6000IU
Selenium 5mg/kg
Compound Chinese herb 200g/kg
All the other are carrier silica;
Said compound Chinese herb by percetage by weight is: 10% Radix Astragali, 10% Radix Codonopsis, 5% rhizoma cyperi, 5% bighead atractylodes rhizome, 10% Radix Angelicae Sinensis, 10% root of herbaceous peony, 10% cultivated land, 10% barrenwort, 10% play both sides of the street, 10% seed of cowherb, 10% motherwort are pulverized mixed preparing and formed.Preparation method: the same.
Embodiment 3
Perinatal period, the milk cow additive formulations was formed (preparing 1 kg):
Rumen-undegraded fat 350g/kg
Vitamin A 600,000 IU
Vitamin E 5000IU
Selenium 4g/kg
Compound Chinese herb 150g
All the other are carrier silica;
Said compound Chinese herb by percetage by weight is: 10% Radix Astragali, 10% Radix Codonopsis, 5% rhizoma cyperi, 5% bighead atractylodes rhizome, 10% Radix Angelicae Sinensis, 10% root of herbaceous peony, 10% cultivated land, 10% barrenwort, 10% play both sides of the street, 10% seed of cowherb, 10% motherwort are pulverized mixed preparing and formed.Preparation method: the same.