CN103142776A - Traditional Chinese medicine composition for treating endometritis of sheep and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating endometritis of sheep and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating endometritis of sheep. The traditional Chinese medicine composition comprises the following components by weight: 20-30 parts of climbing groundsel herb, 30-40 parts of radix sophorae flavescentis, 30-40 parts of scutellaria baicalensis, 30-40 parts of coptis root, 30-40 parts of bighead atractylodes rhizome, 30-40 parts of dandelion, 30-40 parts of herba epimedii, 50-70 parts of motherwort herb, 50-70 parts of codonopsis pilosula, 50-70 parts of herba aristolochiae, 50-70 parts of angelica sinensis, 30-40 parts of cowherb seed, 20-30 parts of pollen typhae, 20-30 parts of astragalus mongholicus and 20-30 parts of liquorice. The invention also discloses a preparation method of the traditional Chinese medicine composition for treating endometritis of sheep. By effectively combining the functions of four core medicines including angelica sinensis, motherwort herb, codonopsis pilosula and herba aristolochiae and eleven auxiliary medicines such as climbing groundsel herb, and by using the preparation method, the contraction of uterine smooth muscles is strengthened, the heat clearing, bacteriostatic and anti-inflammatory effects are achieved, the immunity of the organism is improved, and the pesticide effect of stopping bleeding and easing pain is realized, so that the cure rate of endometritis of sheep is effectively improved, the reproductive capacity of the sheep is enhanced, and financial loss of farmers is reduced. The traditional Chinese medicine composition has great significance for promoting the healthy development of sheep industry.
Description
Technical field
The invention belongs to animal medicinal composition, be specifically related to a kind of Chinese medicine composition and preparation method thereof, relate in particular to a kind of sheep endometritis composition and method of making the same for the treatment of.
Background technology
Endometritis is the inflammation of Uterine mucosa, often causes because the secondary antibacterials such as childbirth, practise midwifery, the prolapsus uteri, vagina are deviate from, placenta retention and peritonitis infect.The endometritis of sheep is a kind of commonly encountered diseases in sheep obstetrics disease, mostly betides ewe birth process or puerperal, and sheep and goat all can be fallen ill, and can occur in the links in reproductive process.
Endometritis can be divided into acute endometritis and chronic endometritis, and chronic endometritis is divided into again chronic mucus endometritis and chronic purulent endometritis according to the character of secretions.Wherein, acute intimitis generally betides birth process, post-abortion or is secondary to placenta retention, and sick sheep symptom is obvious, shows as fervescence more, lethargy, and appetite depression is ruminated and is reduced or give up absolutely; Common hogback, exert duty, often make to urinate posture, flow out dirty red stench secretions from vaginal orifice, but the secondary colpitis.If untimely treatment or treatment improper measures, can be transformed into chronic endometritis, it is not obvious that suffer from the sheep General Symptoms this moment, appetite is slightly poor, vaginal orifice is discharged a small amount of Catarrhal or muddy secretions, contaminated environment not only when the rheuminess thing is discharged from vagina, and can cause suffering from sheep irregular even the stopping that oestrusing and oestrus, Repeat breeding.The inflammation damnification of acute and chronic endometritis all may feed through to myometrium, forms metritis, and perhaps secondary pyometra causes permanent infertilely, causes serious economic loss to sheep husbandry.
At present, the economic loss of bringing in order to reduce the sheep endometritis, except taking various preventive measures, common treatment means comprises following several.(1) flushing purifies the uterus, and washing liquid commonly used is by 0.1%～0.2% ethacridine solution, 0.1% compound iodine solution, 0.1%～0.3% potassium permanganate solution, the mixed liquor of 1% alum solution of 0.1%～0.2% sodium bicarbonate solution and equivalent; Washing liquid is poured in cavity of uterus, then discharge with siphonage and pour into intrauterine disinfectant solution, every day 1 time is till can even doing the liquid-transparent of extremely discharging for 3～4 times; (2) rinse the uterus and be combined with subcutaneous injection, to promote uterine contraction, reduce or stop exudate to absorb; Adopted for 5%～10% sodium chloride solution 200～300ml every day or rinse every other day the uterus 1 time, and along with exudate reduces and the raising of strength of uterine contraction, gradually washing liquid concentration being reduced to 1%, and the minimizing consumption; Subcutaneous or intramuscular injection diethylstilbestrol, pituitrin or oxytocin etc. simultaneously; (3) flushing is combined with intrauterine perfusion antibiotic, after flushing and drain, selects penicillin, each 500,000～1,000,000 IU of streptomycin, or oxytetracycline 0.5g is dissolved in the 100ml cod-liver oil, then adds pituitrin 5IU, injects intrauterine, every day 1 time, after 4～6 days 1 time every other day; (4) Fructus Forsythiae 10g is used in treatment by Chinese herbs, Radix Paeoniae Rubra 4g, and Radix Scutellariae 5g, Cortex Moutan 4g, Semen Persicae 4g, Rhizoma Cyperi 5g, Rhizoma Corydalis 5g, Semen Coicis 5g, Herba Taraxaci 5g, decocting is waited temperature, once gavages; Chronic case is used Herba Leonuri 5g, Radix Angelicae Sinensis 8g, and Pollen Typhae 5g, Rhizoma Chuanxiong 3g, Poria 5g, Semen Persicae 3g, Oletum Trogopterori 4g, Rhizoma Cyperi 4g, decocting wait temperature and add yellow wine 20ml, once gavage, and 1 times/day, 2～3d is a course for the treatment of.
The method of above-mentioned treatment sheep endometritis is all to use the Therapeutic Method of cow endometritis, the method treatments of adopting intrauterine to inject antibiotic and antiseptic and disinfectant drug more, there is shortcomings in these methods: (1) pathogen produces drug resistance to antibiotic, reduces therapeutic effect; (2) antiseptic damages endometrium, and can upset to a certain extent the egodefense function in uterus; (3) inevitable drug residue can affect the fertility of sheep to a certain extent; (4) although intrauterine perfusion antibiotic can be removed some antibacterial, can't eliminate endometrial inflammation or recover reproductive capacity, and need heavy dose of minimal inhibitory concentration (5 μ g/g) that just can reach the endometrium local organization, and therapeutic effect is limited.
Summary of the invention
For the problems referred to above that exist in the treatment for the treatment of sheep endometritis, the present invention has developed a kind of sheep endometritis Chinese medicine composition for the treatment of, described Chinese medicine composition has not only increased substantially the cure rate of sheep endometritis, and with low cost, have no side effect; The invention also discloses the preparation method of described Chinese medicine composition.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of the sheep endometritis, and meter, comprise following various component: 20-30 part Herba Senecionis Scandentis by weight, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae.
A kind of preparation method for the treatment of the Chinese medicine composition of sheep endometritis comprises the following steps:
1. prepare medicament: take 20-30 part Herba Senecionis Scandentis, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae;
2. boil medicament: add 2500-3000 part normal-temperature water in the medicament that 1. prepares to step, soaked 30 minutes; After intense fire boils, adopt slow fire to continue to fry in shallow oil 40-50 minute, filter, obtain medicinal residues and a medicinal liquid; Add again 2000-2500 part normal-temperature water in described medicinal residues, adopted 40-45 at a simmer minute, filter, get the secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, namely obtain the Chinese medicine composition of potion treatment sheep endometritis.
Core drug in the Chinese medicine composition for the treatment of sheep endometritis of the present invention comprises Radix Angelicae Sinensis, Herba Leonuri, Radix Codonopsis and Herba Aristolochiae: (1) Radix Angelicae Sinensis can be strengthened the contraction of uterine smooth muscle, promote the discharge of endometrium foreign body, also have bacteriostasis, can effectively alleviate infection; (2) Herba Leonuri possesses the effect of shrinking the uterus, plays synergism with Radix Angelicae Sinensis; (3) Radix Codonopsis can enhancing human body immunity power, also further strengthened the hemopoietic function of Radix Angelicae Sinensis; (4) Herba Aristolochiae is used for anti-bacteria, and collaborative Radix Angelicae Sinensis alleviates the infection of pathogenic site.Remove above-mentioned core drug, Herba Senecionis Scandentis, Radix Sophorae Flavescentis, Radix Scutellariae, Rhizoma Coptidis, Herba Taraxaci and the Rhizoma Atractylodis Macrocephalae all have very strong analgesic antibacterial anti-inflammatory effect, the infection of auxiliary Radix Angelicae Sinensis, Herba Aristolochiae opposing pathogenic bacteria; Herba Epimedii, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae auxiliary Radix Angelicae Sinensis, Radix Codonopsis improve the immunity of ewe; The auxiliary Radix Angelicae Sinensis of Pollen Typhae, Semen Vaccariae, Herba Leonuri are strengthened uterine contraction, and Pollen Typhae promotes blood coagulation simultaneously, the Semen Vaccariae function of easing pain in addition.Radix Glycyrrhizae except can antiinflammatory, enhancing human body immunity power, also have the flavored action to Chinese medicine composition.
The pharmacological action of various Chinese medicines in the Chinese medicine composition for the treatment of sheep endometritis of the present invention:
(1) Herba Senecionis Scandentis: have heat clearing away, detoxifcation, parasite killing, make eye bright and treat various acutely inflamed effects.Herba Senecionis Scandentis has the broad ectrum antibiotic effect, and staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A, Bacillus paratyphosus B, will he, Bao Shi, bacterium sonnei are all had stronger inhibitory action; The decoct of Herba Senecionis Scandentis, ether extracting solution have In Vitro Anti spirillum effect in various degree; The decoct of Herba Senecionis Scandentis also has certain inhibitory action to trichomonas vaginitis.
(2) Radix Sophorae Flavescentis: the effect with heat clearing and damp drying, parasite killing, diuresis.Radix Sophorae Flavescentis is mainly used in treating hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus and external treatment trichomonal vaginitis; Matrine has obvious diuresis, and the ether extract of Radix Sophorae Flavescentis and ethanol extract have stronger bacteriostasis to staphylococcus aureus.
(3) Radix Scutellariae: the effect with heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive and blood pressure lowering.Radix Scutellariae is mainly used in treating hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood and tells nosebleed, carbuncle sore tumefacting virus and frequent fetal movement.Baicalin, baicalin can effectively suppress acute inflammatory reaction, and baicalin can improve the quantity of macrophage, NK cell in body, thereby improve the immunologic function of body.
(4) Rhizoma Coptidis: the effect with heat clearing and damp drying, eliminating fire and detoxication.Rhizoma Coptidis is inhibited to dysentery bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, Diplococcus pneumoniae, influenza virus, leptospira, ameba and dermatophytes.Rhizoma Coptidis can strengthen leukocytic phagocytic activity, thereby produces function of gallbladder promoting, expansion peripheral vessel, blood pressure lowering and gentle refrigeration function.
(5) Rhizoma Atractylodis Macrocephalae: the effect with invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive and diuresis.The Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic function of reticuloendothelial system, improves lymphocytic conversion ratio, promotes the immunologic function of cell.The decoct of the Rhizoma Atractylodis Macrocephalae all has in various degree bacteriostasis to meningococcus, Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus, acrothesium floccosum, star nocardia etc.
(6) Herba Taraxaci: the effect with heat-clearing and toxic substances removing and dispersing swelling and dissipating binds.Herba Taraxaci has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus, and Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis are also had certain bactericidal action.The decoct of Herba Taraxaci can significantly improve human peripheral lymphocyte blast transformation rate external, improves immunologic function.
(7) Herba Epimedii: have the effect of antibacterial, kidney-replenishing, bone and muscle strengthening and wind-damp dispelling significantly.The active component of Herba Epimedii is icariin and epimedium brevicornum polysaccharide, and Staphylococcus albus, staphylococcus aureus are had remarkable inhibitory action.3,5,7-trihydroxy-2-(4-methoxy-phenyl)-8-(3-methyl-but-2-enyl)-chromen-4-one has excitatory neuron and promotes gonepoietic effect.
(8) Herba Leonuri: be mainly used in treating vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rush down blood and carbuncle skin infection.Leonurine is to escherichia coli, dysentery bacterium, achorion schoenleinii, and Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.Herba Leonuri decoct, ethanol extractum and contained leonurine etc. all are excitation to the uterus of the many animals such as rabbit, cat, dog, Cavia porcellus.
(9) Radix Codonopsis: the effect that possesses invigorating the spleen and replenishing QI and spleen invigorating lung benefiting.Radix Codonopsis contains various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.
(10) Herba Aristolochiae: the effect with circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Herba Aristolochiae can be used for having a stomachache, colicky, edema during pregnancy, puerperal vim and vigour stomachache and the treatment of rheumatalgia.Herba Aristolochiae has certain inhibitory action to staphylococcus aureus and common dermatophytes.
(11) Radix Angelicae Sinensis: possess enrich blood, invigorate blood circulation, menstruction regulating and pain relieving and the effect of moisturizing laxation.Radix Angelicae Sinensis has " amphicheirality " to the effect in uterus, and the excited uterine smooth muscle of its water solublity non-volatile matter mass-energy makes to shrink and strengthens, and its volatile ingredient has the inhibition uterus, reduces its rhythmicity and shrinks, and makes atony of uterus, but both take the composition of excitement as main.Radix Angelicae Sinensis all has certain inhibitory action to dysentery bacterium, Bacillus typhi, escherichia coli, Hemolytic streptococcus.
(12) Semen Vaccariae: possess promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, the lactogenesis of invigorating blood circulation, expedite the emergence of the effect of stimulating milk secretion and thymus dredging in puerperal.Its decoct has contraction to isolated uterine, and the effect of its ethanol immersion is stronger, and aqueous extract makes that tablet is for oral administration has positive effect to lactogenic and the involution of uterus.
(13) Pollen Typhae: the effect that possesses cooling blood for hemostasis and blood circulation promoting and blood stasis dispelling.Pollen Typhae promotes the contraction in uterus, shortens clotting time.Staphylococcus aureus, bacterium flexneri, bacillus pyocyaneus, escherichia coli, Bacillus typhi, the close Shigella flexneri of history and 2 type Salmonella paratyphi all there is stronger inhibitory action.
(14) Radix Astragali: the effect that possesses invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus and expelling pus and promoting granulation.The Radix Astragali can be strengthened normal heart and shrink, and the heart of exhaustion is had cardiotonic; Can expand coronary vasodilator and whole body peripheral vessel, make blood pressure drops; The secretory pit of the inaccessible skin of energy suppresses diaphoresis, therefore anti-hidropoiesis is arranged.
(15) Radix Glycyrrhizae: the effect that possesses invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough and relieving spasm to stop pain.Glycyrrhizin in Radix Glycyrrhizae has stronger Detoxication to the poisoning and diphtheria toxin, diphtherotoxin of food, interior metabolism product, tetanus toxin, snake venom etc.; Glycyrrhizin and enoxolone and its esters have obvious antidiuretic activity; Radix Glycyrrhizae also has antiinflammatory, antianaphylaxis reagentia, and dysentery bacterium, anthrax bacillus, Hemolytic streptococcus, Diplococcus pneumoniae, staphylococcus aureus etc. are had inhibitory action.
Beneficial effect of the present invention:
(1) Chinese medicine composition of the present invention effectively combines Radix Angelicae Sinensis, Herba Leonuri, Radix Codonopsis and Herba Aristolochiae four flavor core medical materials and Herba Senecionis Scandentis etc. ten effect of auxiliary medical material simply, and the preparation method of employing coupling, realized the reinforcement uterine myometrium, analgesic antibacterial anti-inflammatory, improve immunity of organisms and take into account the drug effect of hemostatic analgesia, effectively improved the cure rate of sheep endometritis, improve the fertility of sheep, reduced raiser's economic loss, had great importance to promoting sheep husbandry to develop in a healthy way;
(2) Chinese medicine composition of the present invention is drawn materials extensive, with low cost, easy to use and safe and effective, not only has anti-inflammation, heat-clearing and toxic substances removing, promoting blood circulation and stopping pain and the clear corruption turbid effect of dispelling, and immunity that can enhancing body, not only can reduce and cure the probability that sheep falls ill again, also can improve the resistance against diseases of healthy flock of sheep;
(3) Chinese medicine composition of the present invention has not only improved the cure rate of sheep endometritis greatly, but also improved cure after the fertility of sheep, efficiently solve the problem that the prior art drug residue impacts sheep fertility;
(4) Chinese medicine composition of the present invention has been avoided antibiotic use, and the therefore also drug resistance problem with regard to having avoided causing due to antibiotic use also can not upset the egodefense function in uterus; Adopt this pharmaceutical treatment the case of 82 sheep and goat endometritis show, cure 67, dead and eliminate 15, cure rate reaches 81.7%, and the sheep reproductive capacity after curing increases.
The specific embodiment
The present invention is described further below in conjunction with embodiment.
Embodiment 1:
1. prepare medicament: take the 20g Herba Senecionis Scandentis, 30g Radix Sophorae Flavescentis, 30g Radix Scutellariae, 30g Rhizoma Coptidis, the 30g Rhizoma Atractylodis Macrocephalae, 40g Herba Taraxaci, 30g Herba Epimedii, 50g Herba Leonuri, 50g Radix Codonopsis, 50g Herba Aristolochiae, 50g Radix Angelicae Sinensis, 30g Semen Vaccariae, 20g Pollen Typhae, the 20g Radix Astragali, 20g Radix Glycyrrhizae.
2. boil medicament: add the 2500ml normal-temperature water in the medicament that 1. prepares to step, soaked 30 minutes; After intense fire boils, adopt slow fire to continue to fry in shallow oil 50 minutes, filter, obtain approximately 100ml of medicinal residues and medicinal liquid; Add again the 2000ml normal-temperature water in described medicinal residues, adopted 40 minutes at a simmer, filter, get approximately 100ml of secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, namely obtain the Chinese medicine composition of potion treatment sheep endometritis.
The compositions of the above-mentioned treatment sheep endometritis that is mixed with is down to 25～30 ℃ gavages to sheep, each once, is used in conjunction 5～7 doses 1 dose of every day sooner or later, takes the circumstances into consideration to add and subtract each component dosage according to the state of an illness and the large I of body weight in formula range.
Treatment case 1:2000 April, the author buys the cold sheep of 30 little tails of gestation and is used for the test of the monitoring involution of uterus, treats that sheep divides the puerperium, has 5 sheep to suffer from endometritis.During beginning, suffer from sheep lochia efflux time and extend, lassitude appears in the development along with the state of an illness, fervescence, and loss of appetite, is exerted duty at the back of a bow, flows out mucus or mucopurulent secretion thing from vaginal orifice, and when keeping down, output, is more.5 equal significant prolongations of involution of uterus time of suffering from sheep.Collection intrauterine sample is the bacteriology and is cultivated discovery, and escherichia coli, bacillus cereus, streptococcus, staphylococcus, corynebacterium, klebsiella, micrococcus luteus and bacillus pyocyaneus are arranged.Use sodium ampicillin (3mg/kg, 1 times/day) treatment during beginning, after use enrofloxacin (3mg/kg, 2 times/days) instead, be showed no effect.Use above-mentioned traditional Chinese medicine composition for treating instead, serve on 7 doses 1 dose of every day, medication was suffered from the sheep mental status and is taken a turn for the better after 2 days, and feed intake increases; No longer discharged the mucopurulent secretion thing after medication in 4 days; Gather the uterus sample after medication the 8th day the time and do the antibacterial cultivation, result is all negative, cure rate 100%.After rutting, 5 sheep are all pregnant.
Treat case 2:2001 April, when above-mentioned test is given a birth with sheep, have again 4 sheep to suffer from endometritis, wherein have 1 to be secondary to difficult labour, 1 is secondary to placenta retention.Clinical symptoms shows as: the lochia efflux time extends, fervescence, and loss of appetite, the time is slightly long just from vaginal orifice outflow brown secretions frowzy.This time directly use above-mentioned Chinese medicine composition to treat, divide sooner or later to gavage for 2 times 1 dose of every day, be used in conjunction 7 doses.After 2 doses of medicines, 3 sheep temperature declines are arranged, amount of drinking water and food-intake increase; With fully recovering after 7 doses of medicines, cure rate 75%.There is 1 sheep to die from pyaemia septica.
Embodiment 2:
1. prepare medicament: take the 25g Herba Senecionis Scandentis, 35g Radix Sophorae Flavescentis, 35g Radix Scutellariae, 35g Rhizoma Coptidis, the 35g Rhizoma Atractylodis Macrocephalae, 30g Herba Taraxaci, 40g Herba Epimedii, 65g Herba Leonuri, 60g Radix Codonopsis, 65g Herba Aristolochiae, 60g Radix Angelicae Sinensis, 35g Semen Vaccariae, 25g Pollen Typhae, the 25g Radix Astragali, 30g Radix Glycyrrhizae.
2. boil medicament: add the 2800ml normal-temperature water in the medicament that 1. prepares to step, soaked 30 minutes; After intense fire boils, adopt slow fire to continue to fry in shallow oil 40 minutes, filter, obtain approximately 100ml of medicinal residues and medicinal liquid; Add again the 2200ml normal-temperature water in described medicinal residues, adopted 45 minutes at a simmer, filter, get approximately 100ml of secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, namely obtain the Chinese medicine composition of potion treatment sheep endometritis.
The compositions of the above-mentioned treatment sheep endometritis that is mixed with is down to 25～30 ℃ gavages to sheep, each once, is used in conjunction 5～7 doses 1 dose of every day sooner or later, takes the circumstances into consideration to add and subtract each component dosage according to the state of an illness and the large I of body weight in formula range.
Case 3:2007 is between year May in May to 2009 in treatment, and the author treats for the sick sheep that endometritis is suffered from by the cold sheep of 2 little tails of difference of County of Shandong Province plant.2 plants have respectively endometritis to suffer from 26 and 31 of sheep, and ill sheep all occurs in puerperal, wherein have respectively 3 and 6 sheep to have difficult labour when giving a birth, and 3 and 4 sheep generation placenta retention are separately arranged.Clinical manifestation is: poor appetite, and lassitude, fervescence is ground one's teeth in sleep, and exerts duty, often does the posture of urinating, and flows out dirty red secretions from vaginal orifice, oestruses irregular or stops oestrusing, Repeat breeding.
In two, table 1. sheep field, endometritis is suffered from morbidity and the treatment situation (unit: only) of sheep
| Yang Chang | Suffer from the sheep number | Difficult labour | Placenta retention | Average lambing | Cure | Dead washing in a pan | Cure rate (%) |
| Sheep field 1 | 26 | 3 | 3 | 2.31 | 22 | 4 | 84.6 |
| Sheep field 2 | 31 | 6 | 4 | 2.19 | 25 | 6 | 80.6 |
Embodiment 3:
1. prepare medicament: take the 30g Herba Senecionis Scandentis, 40g Radix Sophorae Flavescentis, 40g Radix Scutellariae, 40g Rhizoma Coptidis, the 40g Rhizoma Atractylodis Macrocephalae, 35g Herba Taraxaci, 35g Herba Epimedii, 70g Herba Leonuri, 70g Radix Codonopsis, 70g Herba Aristolochiae, 70g Radix Angelicae Sinensis, 40g Semen Vaccariae, 30g Pollen Typhae, the 30g Radix Astragali, 25g Radix Glycyrrhizae.
2. boil medicament: add the 3000ml normal-temperature water in the medicament that 1. prepares to step, soaked 30 minutes; After intense fire boils, adopt slow fire to continue to fry in shallow oil 45 minutes, filter, obtain approximately 100ml of medicinal residues and medicinal liquid; Add again the 2500ml normal-temperature water in described medicinal residues, adopted 45 minutes at a simmer, filter, get approximately 100ml of secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, namely obtain the Chinese medicine composition of potion treatment sheep endometritis.
The compositions of the above-mentioned treatment sheep endometritis that is mixed with is down to 25～30 ℃ gavages to sheep, each once, is used in conjunction 5～7 doses 1 dose of every day sooner or later, takes the circumstances into consideration to add and subtract each component dosage according to the state of an illness and the large I of body weight in formula range.
Treat case 4:2003 July 26,2 years old goat of Laiyang City citizen Qi raising is ill.1 lamb is given birth in lambing of this sheep of main suit 5 days, and appetite is bad ever since, and spirit is depressed, and the back of a bow is often done the posture of urinating, and climbs sleepingly, is reluctant to walk about, and cannot see and ruminates.The author checks discovery, and this Corii Caprae seu Ovis hair is slightly random, and spiritual depressed, 39.5 ℃ of body temperature, 82 beats/mins, pulse are breathed 21 beats/mins, and the palpation abdominal part finds have fetus to be stranded in intrauterine, process treatment, the successfully fetus of taking-up delay.But, 2 days future trouble sheep fervescence to 41.5 ℃, vaginal orifice is flowed out dirty red secretions, and drinking-water and feed stop.Be diagnosed as acute endometritis, in the vein fluid infusion, get above-mentioned prescription treatment, be used in conjunction 3 doses, sb.'s illness took a favorable turn, and appetite and drink wish are recovered, and use again 2 doses, discontinue medication, and pay a return visit, and the main suit fully recovers.
Between treatment case 5:2010 year JIUYUE in July to 2011, be total to the diagnosis and treatment endometritis at Shandong Province's Laiyang City goat feed lot and suffer from 15 of sheep, wherein have 6 to be acute endometritis, clinical symptoms shows as inappetence, fervescence, spirit is depressed, ruminate and weaken or stop, slight distension gas flows out the kermesinus juice in vaginal orifice, when keeping down output more, often stick secretions and dry incrustation around vaginal orifice; Other 9 is chronic endometritis, and trouble sheep General Symptoms is not obvious, and appetite slightly subtracts, and lactation amount reduces, and discharges the juice that contains floccule from intravaginal, and the estrus cycle is normal, but Repeat breeding.Through above-mentioned composition treatment, acute 6 merely hit cures 5 (cure rate 83.3%), dead 1; Chronic 9 merely hit cures 6 (cure rate 77.8%), eliminates 3.
Table 2. uses the statistics of traditional Chinese medicine composition for treating sheep endometritis of the present invention
| The treatment case | The treatment number | Cure number | The dead number of washing in a pan | Cure rate % |
| 1 | 5 | 5 | 0 | 100 |
| 2 | 4 | 3 | 1 | 75 |
| 3 | 26 | 22 | 4 | 84.6 |
| 3 | 31 | 25 | 6 | 80.6 |
| 4 | 1 | 1 | 0 | 100 |
| 5 | 15 | 11 | 4 | 73.3 |
| Amount to | 82 | 67 | 15 | 81.7 |
Claims (2)
1. a Chinese medicine composition for the treatment of the sheep endometritis, is characterized in that: count by weight, comprise following various component: 20-30 part Herba Senecionis Scandentis, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae.
2. preparation method for the treatment of the Chinese medicine composition of sheep endometritis is characterized in that: comprise the following steps:
1. prepare medicament: take 20-30 part Herba Senecionis Scandentis, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae;
2. boil medicament: add 2500-3000 part normal-temperature water in the medicament that 1. prepares to step, soaked 30 minutes; After intense fire boils, adopt slow fire to continue to fry in shallow oil 40-50 minute, filter, obtain medicinal residues and a medicinal liquid; Add again 2000-2500 part normal-temperature water in described medicinal residues, adopted 40-45 at a simmer minute, filter, get the secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, namely obtain the Chinese medicine composition of potion treatment sheep endometritis.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104958703A (en) * | 2015-07-17 | 2015-10-07 | 战汪涛 | Pharmaceutical composition for treating chronic endometritis of sheep and preparation method of pharmaceutical composition |
| CN106692343A (en) * | 2017-01-11 | 2017-05-24 | 永安市仁迈信息技术服务有限公司 | Traditional Chinese medicine preparation for treating endometritis of black sheep, and preparation method and application thereof |
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN110938619A (en) * | 2019-12-19 | 2020-03-31 | 北京农学院 | Immobilized enzyme transformed radix scutellariae and application thereof in repairing acetaminophen damage |
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| CN102114171A (en) * | 2009-12-31 | 2011-07-06 | 天津瑞普生物技术股份有限公司 | Traditional Chinese medicine composition for treating cow endometritis |
| CN102578430A (en) * | 2012-03-20 | 2012-07-18 | 天津市畜牧兽医研究所 | Nutrition regulating and controlling additive special for dairy cattle in perinatal period |
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| CN101396464A (en) * | 2008-11-06 | 2009-04-01 | 武瑞 | Traditional Chinese medicine composition for treating cow endometritis |
| CN101623056A (en) * | 2009-07-31 | 2010-01-13 | 山西天沐合生农牧科技开发有限公司 | Chinese herbal medicine feed additive for ewes |
| CN102114171A (en) * | 2009-12-31 | 2011-07-06 | 天津瑞普生物技术股份有限公司 | Traditional Chinese medicine composition for treating cow endometritis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104958703A (en) * | 2015-07-17 | 2015-10-07 | 战汪涛 | Pharmaceutical composition for treating chronic endometritis of sheep and preparation method of pharmaceutical composition |
| CN106692343A (en) * | 2017-01-11 | 2017-05-24 | 永安市仁迈信息技术服务有限公司 | Traditional Chinese medicine preparation for treating endometritis of black sheep, and preparation method and application thereof |
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN110938619A (en) * | 2019-12-19 | 2020-03-31 | 北京农学院 | Immobilized enzyme transformed radix scutellariae and application thereof in repairing acetaminophen damage |
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