CN106692343A - Traditional Chinese medicine preparation for treating endometritis of black sheep, and preparation method and application thereof - Google Patents
Traditional Chinese medicine preparation for treating endometritis of black sheep, and preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating endometritis of black sheep, and a preparation method and application thereof. The preparation is prepared from the following raw materials in parts by weight: 18 to 26 parts of berchemia lineate, 10 to 18 parts of cimicifugae foetidae, 1 to 5 parts of fructus aristolochiae and 15 to 22 parts of oroxylum indicum. The preparation method comprises the following steps: smashing and screening the berchemia lineate and the cimicifugae foetidae, adding deionized water, boiling the solution with intense fire, decocting the solution with soft fire, and carrying out ultrasonic treatment and filtering to obtain filtrate; smashing and screening the fructus aristolochiae and the oroxylum indicum, adding 85 percent of ethyl alcohol for soaking, digesting the solution with water, and carrying out concentration to obtain a concentrated solution; mixing the concentrated solution with the filtrate, and heating, stirring and drying the concentrated solution and the filtrate to obtain the traditional Chinese medicine preparation. Under the synergistic action of all the raw materials, the traditional Chinese medicine preparation can enhance the organism immunity and has the effects of stopping bleeding and relieving pain; the curing rate of the sheep endometritis is effectively increased, and the fertility of the black sheep is greatly improved; the traditional Chinese medicine preparation has the advantages of low toxicity, no residue, difficulty in generation of drug resistance and the like, takes a quick response, and can effectively shorten the treating course and reduce the medicine dose.
Description
Technical field
The present invention relates to veterinary drug technical field, a kind of Chinese medicine preparation for treating black sheep endometritis and its preparation are referred specifically to
Method and application.
Background technology
The black sheep in Dehua has the characteristics of growing fast, meat production and dermatotome quality better.Black sheep muscle fibre is thin, and meat is thin
Tender, delicious flavour, smell of mutton is minimum, is of high nutritive value, and the particularly necessary amino acid of human body particularly enriches, and tonic effect is extremely strong, long
Phase eat, can qi-restoratives, Qiang Ti, be particularly well-suited to old, weak, many patients, often to eat is with black sheep or is equipped with suitable tonic,
To reach the effect of qi-restoratives, health, macrobiosis.The features such as black mutton quality is excellent liked by numerous consumers, hotel food and beverage row
Industry, meat products processing industry increasingly rises to this demand.This mutton is warm in nature sweet, both can tonic, again can dietotherapy, be excellent strong
Strong disease food of dispelling, under having QI invigorating qi-restoratives, middle benefit gas warm, tonifying kidney and strengthening yang, myogenic is good for power, increases immunity of organisms, and it is thin to suppress cancer
The growth of born of the same parents, plays an important role to anti-cancer, anticancer.
But endometritis is common black sheep genital organ disease, be also cause black ewe infertile key factor it
One.Pathogenic factor：Pathogenic microorganism invades uterus by birth canal in ewe birth process, or due to breeding, artificial insemination and connects
Sterilized during product not tight, especially incorrect midwifery, retention of afterbirth, Uterine Prolapse, vagina abjection, tire when having difficult labour
It is medium that youngster dies from abdomen, is easily caused infection and causes endometritis.As treated not in time, uterus necrosis can be developed into, and then
Secondary other organ infections, cause constitutional symptom to aggravate, and cause septicemia or septic septicemia.There is presently no for black sheep
The specific drug of endometritis.
The content of the invention
It is an object of the invention to provide a kind of toxicity is low, noresidue, be not likely to produce drug resistance, fast treatment of responding well to treatment
Chinese medicine preparation of black sheep endometritis and preparation method and application.
In order to solve the above-mentioned technical problem, the present invention is adopted the following technical scheme that：
A kind of Chinese medicine preparation for treating black sheep endometritis, is prepared from by the raw material of following weight portion：Berchemia lineata 18-26
Part, rattletop 10-18 parts, birthwort 1-5 parts and Oroxylum indicum 15-22 parts.
A kind of described Chinese medicine preparation for treating black sheep endometritis, is prepared from by the raw material of following weight portion：Iron
It is covered with gold leaf 20-24 parts, rattletop 12-16 parts, birthwort 2-4 parts and Oroxylum indicum 17-20 parts.
A kind of described Chinese medicine preparation for treating black sheep endometritis, is prepared from by the raw material of following weight portion：Iron
18 parts of covered with gold leaf 22 parts, 14 parts of rattletop, 3 parts of birthwort and Oroxylum indicum.
A kind of preparation method of described Chinese medicine preparation for treating black sheep endometritis, comprises the following steps：
（1）80-150 mesh sieves are crossed after berchemia lineata and rattletop are crushed, the deionized water of the two 8-10 times of quality is added, intense fire is boiled
Open, be cooked by slow fire 1.5-2h, then carry out ultrasonically treated 0.5-0.8h, sonification power is 800W, is filtered to get filtrate；
（2）200 mesh sieves are crossed after birthwort and Oroxylum indicum are crushed, 85% ethanol of the two 15-18 times of quality is added, at 70-75 DEG C
Lower immersion 2-3h, with 2-3 rear merging leaching liquor of flooding, is concentrated into the 22-25% of original volume, obtains final product concentrate；
（3）Concentrate is mixed with filtrate, the heating stirring 40-45min at 150-160 DEG C, then in drying at 100 DEG C
Medicine preparation.
The present invention also provides application of the above-mentioned Chinese medicine preparation in the black sheep endometritis medicine for the treatment of is prepared.
The medicinal efficacy of above-mentioned primary raw material：
Berchemia lineata：Reinforce the kidney QI invigorating, removing blood stasis and hemostasis, antibechic analgesic.For wind toxin streamer, tuberculosis is quenched one's thirst, stomachache, orchitis and epididymitis, seminal emission,
Rheumatic arthritis, soreness of waist and knee joint, traumatic injury, scrofula, urticaria, swollen ulcer drug, acute toothache.
Rattletop：Promoting eruption is delivered, clearing heat and detoxicating, yang invigorating.Gas plague when curing mainly, fever and chills of having a headache, laryngalgia, aphtha, macula
It is impermeable；The sinking of qi of middle-jiao, protracted dysentery and diarrhea, prolapse of the anus, women is collapsed, band, uterus tenesmus；Carbuncle sore tumefacting virus.
Birthwort：Have functions that clearing lung-heat sending down abnormally ascending, relieving cough and asthma, gut purge disappear hemorrhoid, its stem claims the herba aristolochiae to have qi-regulating, clearing damp, work
Effect of blood and relieving pain, its root claims the dutchmanspipe root to have functions that promoting qi circulation and relieving pain, removing toxicity for detumescence.
Oroxylum indicum：The effect of having removing heat from the lung and relieving sorethroat, soothing liver and harmonizing stomach.It is usually used in cough with lung heat, larynx numbness, sound is mute, stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach.
Knowable to the above-mentioned description of this invention, compared to the prior art, the advantage of the invention is that：
The present invention under the synergy of each raw material, for treating black sheep endometritis, cure rate more than 88%, up to
100%.The present invention improves immunity of organisms and takes into account the drug effect of hemostatic analgesia, effectively increases the cure rate of sheep endometritis,
The fertility of black sheep is substantially increased, the economic loss of raiser is reduced, to promoting sheep husbandry to develop in a healthy way with important
Meaning.It is of the invention that there is low toxicity, noresidue, drug resistance is not likely to produce, respond well to treatment fast, can effectively shorten treatment
The course for the treatment of simultaneously reduces dosage.
Specific embodiment
Specific embodiment of the invention is illustrated below
Embodiment one
A kind of Chinese medicine preparation for treating black sheep endometritis, is prepared from by the raw material of following weight portion：18 parts of berchemia lineata, liter
15 parts of 10 parts of fiber crops, 1 part of birthwort and Oroxylum indicum.Its preparation methods steps are as follows：
（1）80 mesh sieves are crossed after berchemia lineata and rattletop are crushed, the deionized water of the two 8 times of quality is added, intense fire is boiled, is cooked by slow fire
1.5h is boiled, then carries out ultrasonically treated 0.5h, sonification power is 800W, is filtered to get filtrate；
（2）200 mesh sieves are crossed after birthwort and Oroxylum indicum are crushed, 85% ethanol of the two 15 times of quality is added, soaked at 70 DEG C
2h, with leaching liquor is merged after flooding 2 times, is concentrated into the 22% of original volume, obtains final product concentrate；
（3）Concentrate is mixed with filtrate, the heating stirring 40min at 150 DEG C, then the drying Chinese medicine preparation at 100 DEG C.
Embodiment two
A kind of Chinese medicine preparation for treating black sheep endometritis, is prepared from by the raw material of following weight portion：26 parts of berchemia lineata, liter
22 parts of 18 parts of fiber crops, 5 parts of birthwort and Oroxylum indicum.Its preparation methods steps are as follows：
（1）150 mesh sieves are crossed after berchemia lineata and rattletop are crushed, the deionized water of the two 10 times of quality is added, intense fire is boiled, slow fire
2h is decocted, then carries out ultrasonically treated 0.8h, sonification power is 800W, is filtered to get filtrate；
（2）200 mesh sieves are crossed after birthwort and Oroxylum indicum are crushed, 85% ethanol of the two 18 times of quality is added, soaked at 75 DEG C
3h, with leaching liquor is merged after flooding 3 times, is concentrated into the 25% of original volume, obtains final product concentrate；
（3）Concentrate is mixed with filtrate, the heating stirring 45min at 160 DEG C, then the drying Chinese medicine preparation at 100 DEG C.
Embodiment three
A kind of Chinese medicine preparation for treating black sheep endometritis, is prepared from by the raw material of following weight portion：20 parts of berchemia lineata, liter
17 parts of 12 parts of fiber crops, 2 parts of birthwort and Oroxylum indicum.Its preparation methods steps are as follows：
（1）120 mesh sieves are crossed after berchemia lineata and rattletop are crushed, the deionized water of the two 9 times of quality is added, intense fire is boiled, slow fire
2h is decocted, then carries out ultrasonically treated 0.8h, sonification power is 800W, is filtered to get filtrate；
（2）200 mesh sieves are crossed after birthwort and Oroxylum indicum are crushed, 85% ethanol of the two 17 times of quality is added, soaked at 75 DEG C
3h, with leaching liquor is merged after flooding 3 times, is concentrated into the 25% of original volume, obtains final product concentrate；
（3）Concentrate is mixed with filtrate, the heating stirring 45min at 155 DEG C, then the drying Chinese medicine preparation at 100 DEG C.
Example IV
The implementation method of the present embodiment and embodiment three is essentially identical, and difference is：
The Chinese medicine preparation of the present embodiment is prepared from by the raw material of following weight portion：24 parts of berchemia lineata, 16 parts of rattletop, birthwort 4
20 parts of part and Oroxylum indicum.
Embodiment five
The implementation method of the present embodiment and embodiment three is essentially identical, and difference is：
The Chinese medicine preparation of the present embodiment is prepared from by the raw material of following weight portion：22 parts of berchemia lineata, 14 parts of rattletop, birthwort 3
18 parts of part and Oroxylum indicum.
Embodiment six
The implementation method of the present embodiment and embodiment five is essentially identical, and difference is：
The Chinese medicine preparation of the present embodiment is prepared from by the raw material of following weight portion：14 parts of rattletop, 3 parts of birthwort and Oroxylum indicum 18
Part.
Embodiment seven
The implementation method of the present embodiment and embodiment five is essentially identical, and difference is：
The Chinese medicine preparation raw material of the present embodiment only includes the weight portion of berchemia lineata 22.
350 are selected at random with the black sheep of endometritis in Dehua, are divided into 7 groups, every group 50, wherein treatment group totally five
Group, respectively treats 1 group, treats 2 groups, treat 3 groups, treat 4 groups, 5 groups for the treatment of, corresponds to use described in embodiment one ~ five respectively
Chinese medicine preparation, totally 2 groups of control group respectively compares 1 group, 2 groups of control, corresponds to respectively using described in embodiment six and embodiment seven
Chinese medicine preparation, age of each group, the course of disease and severity extent aspect comparing difference are without conspicuousness (P>0.05), with comparativity.
The Chinese medicine preparation of the treatment sheep endometritis that each embodiment is configured to is gavaged to sheep, sooner or later respectively once, daily
3g, is used in conjunction 5 days.Treatment results such as following table（Table 1）It is shown.More than 88%, therapeutic effect is preferably to implement to cure rate of the present invention
Example 3,4,5, cure rate more than 98%, optimal is using 5 groups of the treatment of embodiment five, cure rate 100%.The present invention can also be improved
The fertility of the black sheep after healing.
The treatment results of each group of table 1
Treatment case 1：In April, 2014,30 black sheep in pregnant Dehua are used to monitor involution of uterus experiment, after sheep is given a birth, there is 5
Sheep suffers from endometritis.During beginning, suffer from the extension of sheep lochia efflux time, with the development of the state of an illness, lassitude, body temperature occur
Raise, anorexia, the back of a bow, exert duty, from vaginal orifice outflow mucus or mucopurulent secretion thing, discharge rate is more when keeping down.5 trouble
The involution of uterus time of sheep significantly extends.Collection intrauterine specimens do bacteriology culture discovery, there is Escherichia coli, gemma bar
Bacterium, streptococcus, staphylococcus, corynebacteria, klebsiella, micrococcus luteus and Pseudomonas aeruginosa.Start with ammonia benzyl mould
Plain sodium（3mg/kg, 1 times/day）Treatment, after use Enrofloxacin instead（3mg/kg, 2 times/day）, it is showed no effect.Use embodiment 5 instead
Preparation for treating, once a day, each 3g takes medicine continuously 5, after medication 2 days, suffers from the improvement of sheep mental status, and feed intake increases；Medication
Afterwards mucopurulent secretion thing is not then exhausted within 4 days；Uterus sample is gathered after medication at the 6th day and does Bacteria Culture, be as a result feminine gender,
Cure rate 100%.After rutting, 5 sheep are pregnant.
Specific embodiment of the invention is above are only, but design concept of the invention is not limited thereto, it is all to utilize this
Design carries out the change of unsubstantiality to the present invention, all should belong to the behavior for invading the scope of the present invention.
Claims (5)
1. a kind of Chinese medicine preparation for treating black sheep endometritis, it is characterised in that be prepared from by the raw material of following weight portion：
Berchemia lineata 18-26 parts, rattletop 10-18 parts, birthwort 1-5 parts and Oroxylum indicum 15-22 parts.
2. a kind of Chinese medicine preparation for treating black sheep endometritis as claimed in claim 1, it is characterised in that by following weight
The raw material of part is prepared from：Berchemia lineata 20-24 parts, rattletop 12-16 parts, birthwort 2-4 parts and Oroxylum indicum 17-20 parts.
3. a kind of Chinese medicine preparation for treating black sheep endometritis as claimed in claim 2, it is characterised in that by following weight
The raw material of part is prepared from：18 parts of 22 parts of berchemia lineata, 14 parts of rattletop, 3 parts of birthwort and Oroxylum indicum.
4. the preparation method of a kind of Chinese medicine preparation for treating black sheep endometritis as described in claim 1 or 2 or 3, it is special
Levy and be, comprise the following steps：
（1）80-150 mesh sieves are crossed after berchemia lineata and rattletop are crushed, the deionized water of the two 8-10 times of quality is added, intense fire is boiled
Open, be cooked by slow fire 1.5-2h, then carry out ultrasonically treated 0.5-0.8h, sonification power is 800W, is filtered to get filtrate；
（2）200 mesh sieves are crossed after birthwort and Oroxylum indicum are crushed, 85% ethanol of the two 15-18 times of quality is added, at 70-75 DEG C
Lower immersion 2-3h, with 2-3 rear merging leaching liquor of flooding, is concentrated into the 22-25% of original volume, obtains final product concentrate；
（3）Concentrate is mixed with filtrate, the heating stirring 40-45min at 150-160 DEG C, then in drying at 100 DEG C
Medicine preparation.
5. application of the Chinese medicine preparation as described in claim 1 or 2 or 3 in the black sheep endometritis medicine for the treatment of is prepared.
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Application publication date: 20170524 |