CN110393768A - A kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory and its preparation method and application - Google Patents
A kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory and its preparation method and application Download PDFInfo
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Abstract
The invention discloses combined traditional Chinese medicine dabbling drugs of a kind of Gilt Uterus anti-inflammatory and its preparation method and application, are related to technical field of traditional Chinese medicine.The raw material of the drug includes 15-22 parts of kuh-seng, 10-15 parts of field pennycress, 8-13 parts of cordate houttuynia, 5-8 parts of folium artemisiae argyi, 5-10 parts of Rhizoma Chuanxiong, 7-9 parts of lopseed, 5-8 parts of soft muscle rattan, 4-6 parts of Cortex Phellodendri, 2-5 parts of borneol and 2-5 parts of menthol according to parts by weight.Prescription element of the present invention chooses natural plant crude drugs as raw material, without any antibiotic ingredient, it is formulated safe and healthy, pollution-free, medicament residue will not be caused to body, and the present invention has the function of the antibacterial, antiviral, anti-inflammatory of wide spectrum, there is extensive preventive and therapeutic effect to bacterium infection or acute and chronic inflammation of uterus, improve uterus, birth canal restoration of old ways function while treating inflammation, solve the problems such as oestrus of sow is slow, heat is abnormal, Repeat breeding, it plays a role in health care to uterus, improves sow reproductive efficiency.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine, in particular to a kind of combined traditional Chinese medicine of Gilt Uterus anti-inflammatory
Dabbling drug and its preparation method and application.
Background technique
With the fast development of pig-breeding industry, the health status of sow more obtains culturist's attention, wherein female through producing
The hysteritis disease of pig is exactly to perplex the problem of numerous culturists.From the point of view of current breeding situations, most of sows are all
With different degrees of hysteritis.The generation of hysteritis not only will affect sow postpartum breastfeeding, while also will affect oestrus of sow,
The reproductive performance for reducing sow, increases the mortality of sow, brings huge economic loss to farm.The hair of Gilt Uterus inflammation
Cause of disease is because being roughly divided into: 1, bacterium infection.Sow due to difficult labour, retention of afterbirth, Uterine Prolapse, production environment is poor, midwifery when hand
Art is unclean, and operation is lack of standardization, causes vulneratio uteri, postpartum infection pathogen (such as escherichia coli, streptococcus and Pseudomonas aeruginosa)；
2, sow illness causes to infect.Sow is easy secondary infection hysteritis with diseases such as swine fever, parvovirus, pseudoabies；3,
Boar illness causes to infect.Boar genitals illness when natural mating, sperm have rheuminess object or pathogenic bacteria etc., pass through mating
Or insemination infects sow and causes hysteritis.The cause of disease of Gilt Uterus inflammation is complicated, and priming factors are numerous, only to the cause of disease of this disease
There is sufficient understanding with symptom, takes to have targetedly preventing and treating scheme, satisfied effect could be obtained, reduce sow
Hysteritis disease incidence promotes aquaculture to develop in a healthy way.
Currently, most method is all using injection such as pefloxacin, Lin Ke there are many methods for the treatment of Gilt Uterus inflammation
Also uterus is perfused with penicillin etc. in the antibiotic such as mycin, Amoxicillin, has the function that anti-inflammatory restores.But antibiosis in recent years
The abuse of element is widely paid close attention to, and country has issued a series of anti-bulletin of limit for the use of antibiotic.With antibiotic
Gradually limitation use, there is larger growth, Chinese medicine or prescription in treatment sow reproductive disease in the demand of Chinese medicine and products thereof
Research is in golden period, but existing patent document is perfect not enough.
As Chinese patent literature " it is a kind of for treat the slow Chinese veterinary medicinal composition of sow prolonged lochia, heat and
Preparation method (publication number: 104840581 A of CN) " discloses a kind of slow for treating sow prolonged lochia, heat
Chinese veterinary medicinal composition, composition is made of motherwort, Herba Epimedii, safflower, rhizoma corydalis, green peel and Cortex Phellodendri, can accelerate lochia
The exclusion time, but do not have good therapeutic effect also for inflammation of uterus；A for another example Chinese patent literature " broad sow postpartum
Anti-inflammation drugs and preparation method thereof (publication number: 103385919 A of CN) " disclose a kind of anti-inflammatory drug for postpartum sow and its system
Preparation Method, medicine group become: the general life of gentamicin sulphate, a kind of apple, metronidazole, Metoclopramide, big Supreme Being's sweet tea, motherwort, starch, pottery
Soil.Proportionally product is made through granulating process in the above ingredient.Experiments have shown that the invention facilitates the discharge of sow lochia, it is extensive
The restoration of old ways in multiple uterus, but the invention is oral preparations, suitable for the elimination of internal inflammatory factor, for the inflammation of mucomembranous surface
It can not directly act on, anti-inflammatory effects are not so good as topical agent, and most of ingredients are antibiotic or chemical drug ingredient, Yi Zao in prescription
At the drug resistance and medicament residue problem of flora in sow body.
It has been investigated that existing Chinese medicine or prescription be in treatment sow reproductive disease, for Gilt Uterus mucomembranous surface
Inflammation cannot play positive therapeutic effect.
In consideration of it, the present invention is specifically proposed.
Summary of the invention
The purpose of the present invention is to provide a kind of combined traditional Chinese medicine dabbling drugs of Gilt Uterus anti-inflammatory, viscous to Gilt Uterus
The inflammation of film surface has positive therapeutic effect.
Another object of the present invention is to provide a kind of preparation method of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory,
The preparation method is simple, is easy to implement, and the combined traditional Chinese medicine dabbling drug for preparing the Gilt Uterus anti-inflammatory of formation is directly made through being perfused
For Gilt Uterus mucomembranous surface, to treat the inflammation on uterine mucosa surface.
Another object of the present invention is to provide a kind of applications of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory.
The present invention is implemented as follows:
In a first aspect, the embodiment of the present invention provides a kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory, raw material is pressed
Parts by weight meter include 15-22 parts of kuh-seng, 10-15 parts of field pennycress, 8-13 parts of cordate houttuynia, 5-8 parts of folium artemisiae argyi, 5-10 parts of Rhizoma Chuanxiong, thoroughly
7-9 parts of bone grass, 5-8 parts of soft muscle rattan, 4-6 parts of Cortex Phellodendri, 2-5 parts of borneol and 2-5 parts of menthol.
In alternative embodiments, raw material includes 15-18 parts of kuh-seng, 10-12 parts of field pennycress, fish according to parts by weight
8-10 parts of raw meat grass, 5-6 parts of folium artemisiae argyi, 5-7 parts of Rhizoma Chuanxiong, 7-8 parts of lopseed, 5-7 parts of soft muscle rattan, 4-5 parts of Cortex Phellodendri, 2-4 parts of borneol and
2-4 parts of menthol.
In alternative embodiments, the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory is gel, the sow
The raw material of the combined traditional Chinese medicine dabbling drug of uterus anti-inflammatory includes thickener；
Preferably, the thickener includes the mixture of one or both of Gantrez AN-119 and xanthan gum；
Preferably, the raw material is added to 8-12 times of quality of material of water, decocts 2-3h, extracting solution is collected, decocts 2-3
It is secondary, merge the extracting solution, extracting solution described after merging is concentrated into the 40-60% of the total volume of the extracting solution, obtains dense
Contracting liquid, the additional amount of the thickener are the 0.2-0.8% of the volume of the concentrate；
Preferably, the additional amount of the thickener is the 0.4-0.6% of the volume of the concentrate.
In alternative embodiments, the pH value of the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory is 4-5.
Second aspect, the embodiment of the present invention provide a kind of preparation side of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory
Method, the raw material of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory as described in the previous embodiments is extracted, and collection mentions
Take liquid.
In alternative embodiments, extracting the raw material includes:
First by the kuh-seng, field pennycress, the cordate houttuynia, the folium artemisiae argyi, the Rhizoma Chuanxiong, the lopseed, described
Soft muscle rattan and the Cortex Phellodendri crush, and mixing and water adding extracts, and the extracting solution is concentrated to give concentrate,
Then it is added in the concentrate after crushing the borneol and the menthol.
In alternative embodiments, extracting in water includes: the water for being added 8-12 times of quality of material, decocts 2-3h, is collected
Extracting solution decocts 2-3 times, merges the extracting solution, and extracting solution described after merging is concentrated into the total volume of the extracting solution
40-60%；
Preferably, before the extracting solution is concentrated, first the extracting solution is stood overnight, takes supernatant, so
The 40-60% of the volume of the supernatant is filtered and is concentrated into the supernatant afterwards.
In alternative embodiments, thickener is added to the concentrate, heating mixes, and gel is made；
Preferably, the additional amount of the thickener is the 0.2-0.8% of the volume of the concentrate.
It in alternative embodiments, further include adjusting the sow after the thickener is added and heats mixing
The pH value of the combined traditional Chinese medicine dabbling drug of uterus anti-inflammatory is to 4-5.
Preferably, by the way that potassium dihydrogen phosphate, lemon are added into the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory
One of acid and potassium citrate or a variety of pH value to adjust the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory.
The third aspect, the embodiment of the present invention provide the combination such as the described in any item Gilt Uterus anti-inflammatory of aforementioned embodiments
The preparation of Chinese medicinal perfusion drug or the combined traditional Chinese medicine dabbling drug such as the described in any item Gilt Uterus anti-inflammatory of aforementioned embodiments
The combined traditional Chinese medicine dabbling drug for the Gilt Uterus anti-inflammatory that method is prepared is in the drug as treatment treating sow metritis
Using.
The invention has the following advantages: instant component selects kuh-seng and Cortex Phellodendri as monarch drug in a prescription, both of which has
The effect of bactericidal, can effectively inhibit the growth of uterine bacteria.It selects field pennycress and cordate houttuynia as ministerial drug, can rise
It is acted on to the clearing heat and detoxicating, carbuncle that disappears apocenosis, effectively inhibition inflammatory factor, control inflammation further development.Inhibit in kuh-seng and Cortex Phellodendri
While uterine bacteria is grown, inflammation can be further suppressed, to play the effect for the treatment of is reinforced in assistance.It selects deep
Grass, folium artemisiae argyi, Rhizoma Chuanxiong and soft muscle rattan have wind-expelling pain-stopping, relaxing tendons and activating collaterals and analgesic activity, answer as adjutant, the cooperation of these drugs
For uterus, uterine contraction can be effectively facilitated, accelerate the discharge of Inflammatory substances, lochia etc., reduce birth canal, uterus restoration of old ways when
Between.Select borneol and menthol as medicine is made, the cooperation of the two makes the perfusion medicine while capable of increasing product analgesic effect
Object has refrigerant sense, mitigates sow because of uterus because inflammation bring heat is keenly felt, plays dispelling wind, heat-clearing, analgesic effect.
In addition, the preparation method of the application is simple, it is easy to implement, the combined traditional Chinese medicine for preparing the Gilt Uterus anti-inflammatory of formation fills
Injection object is directly entered in Gilt Uterus through perfusion, and the effective component of drug directly acts on Gilt Uterus mucomembranous surface, sow
Body can fully absorb effective ingredient, more preferably to the therapeutic effect of the inflammation of uterus mucomembranous surface.In the present embodiment
It is extracted by the effective component to various raw materials, the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory of acquisition is to sow
The inflammation of palace mucomembranous surface has positive therapeutic effect.
Prescription element of the present invention chooses natural plant crude drugs as raw material substantially, is substantially free of antibiotic composition, formula peace
Entirely, health, pollution-free, will not cause medicament residue to body, and the present invention has the antibacterial, antiviral, anti-inflammatory of wide spectrum
Effect has extensive preventive and therapeutic effect to bacterium infection or acute and chronic inflammation of uterus, improves uterus, birth canal while treating inflammation
Restoration of old ways function solves the problems such as oestrus of sow is slow, heat is abnormal, Repeat breeding, plays a role in health care to uterus, improves female
Pig reproductive efficiency.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
The present invention provides a kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory, raw material includes according to parts by weight
15-22 parts of kuh-seng, 10-15 parts of field pennycress, 8-13 parts of cordate houttuynia, 5-8 parts of folium artemisiae argyi, 5-10 parts of Rhizoma Chuanxiong, 7-9 parts of lopseed, soft muscle
5-8 parts of rattan, 4-6 parts of Cortex Phellodendri, 2-5 parts of borneol and 2-5 parts of menthol.
Wherein, kuh-seng, Cortex Phellodendri have clearing heat and detoxicating, bacterio static itching-relieving and other effects；Kuh-seng is used for hot dysentery, leukorrhea with reddish discharge, swelling of vulva
The illnesss such as itch, kuh-seng have significant ground curative effect to trichomonas vaginitis；Cortex Phellodendri is used for stranguria with turbid discharge, hematochezia, leukorrhea with reddish discharge, aphthae
Etc. illnesss, and to trichomonas vaginitis have good therapeutic effect.Field pennycress, cordate houttuynia have clearing heat and detoxicating, the carbuncle that disappears apocenosis
And other effects；Field pennycress is for illnesss such as acute appendicitis, pulmonary abscess, sore and toxic, postpartum stasis abdominal pain；Cordate houttuynia is for lung carbuncle pyemesis heat
Leaching, the illnesss such as carbuncle sore tumefacting virus.Folium artemisiae argyi, Rhizoma Chuanxiong, lopseed, soft muscle rattan have blood-activating and qi-promoting, wind-expelling pain-stopping and other effects；Folium artemisiae argyi is used for
Blood under vaginal bleeding during pregnancy, abdomen crymodynia are uncomfortable through trembling with fear, and uterus cold infertile controls the illnesss such as pruitus outside；Rhizoma Chuanxiong is used for irregular menstruation, menostasis
Dysmenorrhea, the illnesss such as abdominal mass abdominal pain；Lopseed is for controlling rheumatic arthralgia, muscles and bones contracture, the illnesss such as ringworm sore pyogenic infections；Soft muscle rattan is used for wind
The illnesss such as arthritis with fixed pain caused by dampness pain, lumbar muscle strain, limb paralysis, traumatic injury.Borneol and menthol have dispelling wind, heat dissipation, clearing away heat to and alleviating pain etc.
Effect；Borneol is for illnesss such as pyreticosis coma, hot eyes, aphtha, abscess of throat, purulent ear canals；Menthol is swollen for hot eyes, throat
Bitterly, the illnesss such as food stagnation inflatable, aphtha, toothache, sore scabies, urticaria.
Instant component selects kuh-seng and Cortex Phellodendri as monarch drug in a prescription, and both of which has effects that bactericidal, can be effective
Inhibit the growth of uterine bacteria.Pig trichomoniasis is the trichomonal a kind of protozoon of pig by Trichomonadidae Trichomonas
Disease.Sow is increased after pig infection with vaginal fluid, oestrous cycle disorder, and early stage stream occurs after Repeat breeding and gestation after heat
Situations such as production, the application are cooperated by kuh-seng and Cortex Phellodendri, wherein 15-22 parts of kuh-seng, 4-6 parts of Cortex Phellodendri can sufficiently inhibit uterus
The growth of interior bacterium is conducive to reinforce the therapeutic effect to trichomonas vaginitis.
It selects field pennycress and cordate houttuynia as ministerial drug in the application, the clearing heat and detoxicating, carbuncle that disappears apocenosis can be played the role of, effectively
Inhibit inflammatory factor, control inflammation further development.It, can be into one while kuh-seng and Cortex Phellodendri inhibit intrauterine bacterial growth
Step inhibits inflammation, to play the effect for the treatment of is reinforced in assistance.
Select lopseed, folium artemisiae argyi, Rhizoma Chuanxiong and soft muscle rattan as adjutant in the application, the cooperation of these drugs stops with wind-dispelling
Bitterly, relaxing tendons and activating collaterals and analgesic activity are applied to uterus, can effectively facilitate uterine contraction, accelerate the row of Inflammatory substances, lochia etc.
Out, the restoration of old ways time of birth canal, uterus is reduced.Especially, the cooperation of lopseed, folium artemisiae argyi, Rhizoma Chuanxiong and soft muscle rattan these four drugs, energy
Enough play the role of complementary.Wherein, soft muscle rattan can reinforce the effect of the drug, accelerate the discharge of lochia, shorten birth canal,
The recovery time in uterus.
Select borneol and menthol as medicine is made in the application, the cooperation of the two can increase the same of product analgesic effect
When make the perfusion gel have refrigerant sense, mitigate sow because uterus because inflammation bring heat keenly feel, play dispelling wind, heat-clearing, analgesia
Effect.
Preferably, raw material include according to parts by weight 15-18 parts of kuh-seng, 10-12 parts of field pennycress, 8-10 parts of cordate houttuynia,
5-6 parts of folium artemisiae argyi, 5-7 parts of Rhizoma Chuanxiong, 7-8 parts of lopseed, 5-7 parts of soft muscle rattan, 4-5 parts of Cortex Phellodendri, 2-4 parts of borneol and 2-4 parts of menthol.
Further, the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory in the application is gel, is also wrapped in component
Include the thickener as auxiliary material；Preferably, thickener includes the mixing of one or both of Gantrez AN-119 and xanthan gum
Object.Thickener enables to extract sticky, forms gel preparations, and on the market the dosage form of relevant product mainly with suppository and
Based on lotion.Suppository is disadvantageous in that medication is uneven because of medicine retention vagina or uterus overlong time, there is foreign body sensation,
Tablet acting surface is too small, cannot cover affected part comprehensively, and therapeutic effect is undesirable, and tablet largely absorbs moisture in birth canal, and needs
Certain temperature could dissolve, and easily cause local drug concentration excessive, damage mucous membrane, cause bleeding, use for a long time can generate greatly
Measure novel drug-resistant virus.The place of supplying of lotion is that time of contact is short, is easy to run off, cannot go deep at gauffer inner disease foci, loses
Hidden danger is stayed, and influences the acid-base balance of uterus or vagina, does not advocate use.Prescription of the invention is quenched by preparation process's
It is in afterwards gel, can be very good to be adhered to skin surface, be injected into the uterus of sow, it is not easy to flows out, while the perfusion is solidifying
Glue has certain mobility again, and uterus surface can be completely covered, and effective component is easy to go deep into gauffer, and sow body can fill
Divide the effective component that absorbs the drug.
And specifically, it is preferable to which ground, raw material is mixed after extracting, concentration, concentrate is obtained, the additional amount of thickener is concentrate
Volume 0.2-0.8%；Preferably, the additional amount of thickener is the 0.4-0.6% of the volume of concentrate.The dosage can protect
Demonstrate,proving gelling agent has good adhesiveness and mobility.
In addition, the pH value of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory is 4-5, the pH value and sow in the application
Reproductive organs pH value is close, has no effect on the acid-base balance of sow biological organs.
Prescription element of the present invention chooses natural plant crude drugs as raw material, and no any antibiotic ingredient is formulated safe, strong
It is health, pollution-free, medicament residue will not be caused to body, and the present invention has the function of the antibacterial, antiviral, anti-inflammatory of wide spectrum,
There is extensive preventive and therapeutic effect to bacterium infection or acute and chronic inflammation of uterus, improves uterus, birth canal restoration of old ways function while treating inflammation
Can, the problems such as oestrus of sow is slow, heat is abnormal, Repeat breeding is solved, is played a role in health care to uterus, sow breeding is improved
Efficiency.
Second aspect, present invention also provides the preparation method of the combined traditional Chinese medicine dabbling drug of above-mentioned Gilt Uterus anti-inflammatory,
Itself the following steps are included:
S1, extraction.
Extracting in water after all raw materials are mixed.Specific in the application, first by kuh-seng, field pennycress, cordate houttuynia, Chinese mugwort
Leaf, Rhizoma Chuanxiong, lopseed, soft muscle rattan and Cortex Phellodendri crush respectively, and cross 20-30 mesh, then put into Chinese medicine extracting tank, admixture
The water of 8-12 times of quality of material decocts 2-3h, collects extracting solution, decocts 2-3 times, combined extract, extracting solution after merging is concentrated
To the 40-60% of the total volume of extracting solution.
Before extracting solution is concentrated, selectively first extracting solution is stood overnight, supernatant is taken, then to supernatant
Liquid is filtered and is concentrated into the 40-60% of the volume of supernatant.The operation of supernatant is taken to enable to extract after standing overnight
Constituent part sedimentation in liquid, so that last component is more stable.
Then it is added in concentrate after crushing borneol and menthol.
S2, gel is made.
Thickener is added to concentrate, heating mixes；Preferably, the additional amount of thickener is the volume of concentrate
0.2-0.8%.
S3, pH is adjusted.
The pH value of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory is adjusted to 4-5.In the application, for adjusting sow
The material of the pH of the combined traditional Chinese medicine dabbling drug of palace anti-inflammatory can for one of potassium dihydrogen phosphate, citric acid and potassium citrate or
It is a variety of.
S4, sterilizing, encapsulating.
Product after the completion of above-mentioned adjusting carries out to conventional disinfecting action, subsequent encapsulating to get.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment one
A kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory the preparation method is as follows:
Choose 20 parts of kuh-seng, 12 parts of field pennycress, 11 parts of cordate houttuynia, 6 parts of folium artemisiae argyi, 8 parts of Rhizoma Chuanxiong, 8 parts of lopseed, soft muscle rattan 6
Part, 5 parts of Cortex Phellodendri crushed the mixing of 24 meshes respectively, puts into Chinese medicine extracting tank, 10 times of water of quality of material are added, decocts 3 times,
Each 2h is collected, combined extract, is stood overnight, take supernatant, is filtered, and filtrate is concentrated into the 50% of supernatant volume；By ice
3 parts and 4 parts of menthol of piece are ground together, are added in concentrate；Gantrez AN-119 is added by 0.6% volume of concentrate,
Heating mixes, and adjusting pH value is 4.5, and sticky liquid is made, and sterilizes, encapsulating is to get medical fluid one.
Embodiment two
A kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory the preparation method is as follows:
Choose 15 parts of kuh-seng, 10 parts of field pennycress, 8 parts of cordate houttuynia, 5 parts of folium artemisiae argyi, 5 parts of Rhizoma Chuanxiong, 7 parts of lopseed, soft muscle rattan 5
Part, 4 parts of Cortex Phellodendri, crushed the mixing of 24 meshes respectively, put into Chinese medicine extracting tank, 8 times of water of quality of material are added, decoct 3 times, often
Secondary 2h is collected, combined extract, is stood overnight, take supernatant, is filtered, and filtrate is concentrated into the 50% of supernatant volume；By borneol
2 parts and 2 parts of menthol are ground together, are added in concentrate；Gantrez AN-119 is added by 0.5% volume of concentrate, adds
Heat mixes, and adjusting pH value is 4.5, and sticky liquid is made, and sterilizes, encapsulating is to get medical fluid two.
Embodiment three
A kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory the preparation method is as follows:
Choose 22 parts of kuh-seng, 15 parts of field pennycress, 13 parts of cordate houttuynia, 8 parts of folium artemisiae argyi, 10 parts of Rhizoma Chuanxiong, 9 parts of lopseed, soft muscle rattan 8
Part, 6 parts of Cortex Phellodendri crushed the mixing of 24 meshes respectively, puts into Chinese medicine extracting tank, 12 times of water of quality of material are added, decocts 3 times,
Each 2h is collected, combined extract, is stood overnight, take supernatant, is filtered, and filtrate is concentrated into the 45% of supernatant volume；By ice
5 parts and 5 parts of menthol of piece are ground together, are added in concentrate；Xanthan gum is added by 0.8% volume of concentrate, heating is mixed
Even, adjusting pH value is 4, and sticky liquid is made, and is sterilized, encapsulating is to get medical fluid three.
Example IV
A kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory the preparation method is as follows:
Choose 19 parts of kuh-seng, 11 parts of field pennycress, 13 parts of cordate houttuynia, 7 parts of folium artemisiae argyi, 9 parts of Rhizoma Chuanxiong, 8 parts of lopseed, soft muscle rattan 7
Part, 6 parts of Cortex Phellodendri crushed the mixing of 24 meshes respectively, puts into Chinese medicine extracting tank, 11 times of water of quality of material are added, decocts 3 times,
Each 2h is collected, combined extract, is stood overnight, take supernatant, is filtered, and filtrate is concentrated into the 50% of supernatant volume；By ice
4 parts and 4 parts of menthol of piece are ground together, are added in concentrate；Xanthan gum is added by 0.2% volume of concentrate, heating is mixed
Even, adjusting pH value is 5, and sticky liquid is made, and is sterilized, encapsulating is to get medical fluid four.
Embodiment five
The present embodiment and embodiment two are essentially identical, and difference is, by Gantrez AN-119 (thickener) in embodiment two
It omits, is prepared into lotion.
Embodiment six
Clinical application case: to the therapeutic effect of Gilt Uterus inflammation
Hysteritis identification is carried out to a group Postpartum anestrus or repeatly with the sow that do not cherish, choosing has being produced for inflammation infection female
Pig 180,6 groups are randomly divided into, every group 30, group is control group, one group of medical fluid, two groups of medical fluid, three groups of medical fluid, four groups of medical fluid
With five groups of medical fluid.Control group is dissolved in 100ml physiological saline using the penicillin of 3,000,000 units and is irrigated, and one group of medical fluid
~five groups are perfused the resulting medical fluid 100ml of above-described embodiment respectively, and each test group is primary every perfusion in 2 days, is used in conjunction 3 times；Each group
Uterus is cleaned using the potassium permanganate of 0.9% sodium chloride+0.1% before drug is perfused.The heat of test data sheet sow
Situation and pregnancy rate, record result please refer to table 1.
The heat situation and pregnancy rate of 1. sow of table
Note: pregnancy rate %=becomes pregnant number/heat number * 100%
Interpretation of result: test result shows that gel is perfused compared to penicillin using the test group of present invention perfusion gel
Control group, the Oestrus rate that one group to five groups of medical fluid of medical fluid is superior to control group；Sow is followed by being bred in heat, and one group of medical fluid
Also it is significantly better than control group to five groups of pregnancy rate of medical fluid, the effect that two groups of medical fluid is substantially better than other medical fluid groups, this is because
The combination of drug formulations dosage in two groups of medical fluid is more preferably.The effect that five groups of medical fluid is significantly worse than remaining medical fluid group, this is because
Washing lotion can not be goed deep at gauffer inner disease foci, and hidden danger is left, and be easy to run off, and one group to four groups of the application Chinese medicine liquid, manufactured gel
It can be very good to be adhered to skin surface, be injected into the uterus of sow, it is not easy to flow out, while the perfusion gel has centainly again
Mobility, uterus surface can be completely covered, effective component is easy to go deep into gauffer, and sow body, which can fully absorb drug, to be had
Imitate ingredient.
Comparative example one
Lopseed, folium artemisiae argyi, Rhizoma Chuanxiong and soft muscle rattan in embodiment two, which is replaced with, conventional there is blood-activating and qi-promoting, wind-dispelling to stop
The component of pain effect, i.e., by lopseed replace with it is deep disappear, folium artemisiae argyi replaces with motherwort, Rhizoma Chuanxiong replaces with Radix Angelicae Sinensis and soft muscle rattan is replaced
It is changed to ramulus cinnamomi.
Comparative example two
Soft muscle rattan in embodiment two is replaced with into ramulus cinnamomi.
Comparative example three
Soft muscle rattan in embodiment two is omitted.
Hysteritis identification is carried out to a group Postpartum anestrus or repeatly with the sow that do not cherish, choosing has being produced for inflammation infection female
Pig 90,3 groups are randomly divided into, every group 30, group is one group of comparative example, two groups of comparative example, three groups of comparative example.Comparative example one
Group, two groups of comparative example, three groups of comparative example the resulting medical fluid 100ml of above-mentioned comparative example one-three is perfused respectively, each test group is every 2
Its perfusion is primary, is used in conjunction 3 times；Each group is cleaned using the potassium permanganate of 0.9% sodium chloride+0.1% before drug is perfused
Uterus.The heat situation and pregnancy rate of test data sheet sow are compared with two groups of medical fluid.Record result please refers to table 2.
The heat situation and pregnancy rate of 2. sow of table
As can be seen from the above table, two groups of medical fluid of effect is best, thus illustrates, uses the medical fluid two of present invention perfusion gel
For group compared to comparative example group, two groups of medical fluid of oestrus of sow rate and pregnancy rate are above the level of comparative example group；Experimental result table
Bright, the combination of lopseed, folium artemisiae argyi, Rhizoma Chuanxiong and soft muscle rattan these four Chinese medicines can effectively facilitate uterine contraction, accelerate inflammatory object
The discharge of matter, lochia etc. reduces the restoration of old ways time of birth canal, uterus, and Oestrus rate and pregnancy rate to sow increase significantly.
In conclusion instant component selects kuh-seng and Cortex Phellodendri as monarch drug in a prescription, both of which has effects that bactericidal,
The growth of uterine bacteria can effectively be inhibited.It selects field pennycress and cordate houttuynia as ministerial drug, can play that clearing heat and detoxicating, disappear carbuncle
Apocenosis effect, effectively inhibition inflammatory factor, control inflammation further development.Inhibit intrauterine bacterial growth in kuh-seng and Cortex Phellodendri
Meanwhile, it is capable to inflammation be further suppressed, to play the effect for the treatment of is reinforced in assistance.Select lopseed, folium artemisiae argyi, Rhizoma Chuanxiong and soft muscle
Rattan has wind-expelling pain-stopping, relaxing tendons and activating collaterals and analgesic activity, is applied to uterus as adjutant, the cooperation of these drugs, can be effective
Promote uterine contraction, accelerate the discharge of Inflammatory substances, lochia etc., reduces the restoration of old ways time of birth canal, uterus.Select borneol and peppermint
For brain as medicine is made, the cooperation of the two makes the perfusion gel have refrigerant sense while capable of increasing product analgesic effect, mitigates
Sow, because inflammation bring heat is keenly felt, plays dispelling wind, heat-clearing, analgesic effect because of uterus.
In addition, the preparation method of the application is simple, it is easy to implement, the gel prepared can be directly entered mother through perfusion
Pig intrauterine is simultaneously adhered to skin surface well, it is not easy to it flows out, while the perfusion gel has certain mobility again, it can
Uterus surface is completely covered, effective component is easy to go deep into gauffer, and the effective component of drug directly acts on Gilt Uterus mucous membrane
Surface, sow body can fully absorb effective ingredient, and to treat the inflammation on uterine mucosa surface, therapeutic effect is more preferably.
Prescription element of the present invention chooses natural plant crude drugs as raw material, and no any antibiotic ingredient is formulated safe, strong
It is health, pollution-free, medicament residue will not be caused to body, and the present invention has the function of the antibacterial, antiviral, anti-inflammatory of wide spectrum,
There is extensive preventive and therapeutic effect to bacterium infection or acute and chronic inflammation of uterus, improves uterus, birth canal restoration of old ways function while treating inflammation
Can, the problems such as oestrus of sow is slow, heat is abnormal, Repeat breeding is solved, is played a role in health care to uterus, sow breeding is improved
Efficiency.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory, which is characterized in that its raw material includes hardship according to parts by weight
Join 15-22 parts, 10-15 parts of field pennycress, 8-13 parts of cordate houttuynia, 5-8 parts of folium artemisiae argyi, 5-10 parts of Rhizoma Chuanxiong, 7-9 parts of lopseed, soft muscle rattan
5-8 parts, 4-6 parts of Cortex Phellodendri, 2-5 parts of borneol and 2-5 parts of menthol.
2. the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 1, which is characterized in that its raw material is by weight
Measuring number meter includes 15-18 parts of kuh-seng, 10-12 parts of field pennycress, 8-10 parts of cordate houttuynia, 5-6 parts of folium artemisiae argyi, 5-7 parts of Rhizoma Chuanxiong, lopseed
7-8 parts, 5-7 parts of soft muscle rattan, 4-5 parts of Cortex Phellodendri, 2-4 parts of borneol and 2-4 parts of menthol.
3. the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 1, which is characterized in that sow
The combined traditional Chinese medicine dabbling drug of palace anti-inflammatory is gel, and the raw material of the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory includes increasing
Thick dose；
Preferably, the thickener includes the mixture of one or both of Gantrez AN-119 and xanthan gum；
Preferably, the raw material is added to 8-12 times of quality of material of water, decocts 2-3h, extracting solution is collected, decocts 2-3 times, is closed
And the extracting solution, extracting solution described after merging is concentrated into the 40-60% of the total volume of the extracting solution, obtains concentrate,
The additional amount of the thickener is the 0.2-0.8% of the volume of the concentrate；
Preferably, the additional amount of the thickener is the 0.4-0.6% of the volume of the concentrate.
4. the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 3, which is characterized in that sow
The pH value of the combined traditional Chinese medicine dabbling drug of palace anti-inflammatory is 4-5.
5. a kind of preparation method of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory, which is characterized in that will be such as claim 1 institute
The raw material of the combined traditional Chinese medicine dabbling drug for the Gilt Uterus anti-inflammatory stated extracts, and collects extracting solution.
6. the preparation method of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 5, which is characterized in that
Extracting the raw material includes:
First by the kuh-seng, the field pennycress, the cordate houttuynia, the folium artemisiae argyi, the Rhizoma Chuanxiong, the lopseed, the soft muscle
Rattan and the Cortex Phellodendri crush, and mixing and water adding extracts, and the extracting solution is concentrated to give concentrate,
Then it is added in the concentrate after crushing the borneol and the menthol.
7. the preparation method of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 6, which is characterized in that
Extracting in water includes: the water for being added 8-12 times of quality of material, decocts 2-3h, collects extracting solution, decocts 2-3 times, mention described in merging
Liquid is taken, extracting solution described after merging is concentrated into the 40-60% of the total volume of the extracting solution；
Preferably, before the extracting solution is concentrated, first the extracting solution is stood overnight, takes supernatant, it is then right
The supernatant is filtered and is concentrated into the 40-60% of the volume of the supernatant.
8. the preparation method of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 7, which is characterized in that
It further include that thickener is added to the concentrate, heating mixes, and gel is made；
Preferably, the additional amount of the thickener is the 0.2-0.8% of the volume of the concentrate.
9. the preparation method of the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to claim 8, which is characterized in that
It further include the combined traditional Chinese medicine dabbling drug for adjusting the Gilt Uterus anti-inflammatory after the thickener is added and heats mixing
PH value is to 4-5；
Preferably, by into the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory be added potassium dihydrogen phosphate, citric acid and
One of potassium citrate or a variety of pH value to adjust the combined traditional Chinese medicine dabbling drug of the Gilt Uterus anti-inflammatory.
10. the combined traditional Chinese medicine dabbling drug of Gilt Uterus anti-inflammatory according to any one of claims 1-4 or such as claim 5-9
The Gilt Uterus anti-inflammatory that the preparation method of the combined traditional Chinese medicine dabbling drug of described in any item Gilt Uterus anti-inflammatory is prepared
Application of the combined traditional Chinese medicine dabbling drug in the drug as treatment treating sow metritis.
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