CN105412861A - Traditional Chinese medicine composition for treating tubal nowhere and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating tubal nowhere and preparation method thereof Download PDF

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CN105412861A
CN105412861A CN201510838690.2A CN201510838690A CN105412861A CN 105412861 A CN105412861 A CN 105412861A CN 201510838690 A CN201510838690 A CN 201510838690A CN 105412861 A CN105412861 A CN 105412861A
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chinese medicine
medicine composition
fallopian tube
radix
obstruction
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梁苑春
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Abstract

The invention relates to a traditional Chinese medicine composition for treating tubal nowhere and a preparation method thereof. The traditional Chinese medicine composition is prepared from radix maclurae, leeches, salvia miltiorrhiza, motherwort, dried gingers, pangolin scales, polygala fallax hemsl, herba saururi chinensis, eucommia barks, rhizoma polygoni cuspidati, radix angelica sinensis, flos carthami and liquidambaris fructus. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis and clearing and activating the channels and collaterals and is mainly used for treating infertility caused by the tubal nowhere.

Description

A kind of Chinese medicine composition for the treatment of obstruction of fallopian tube and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of obstruction of fallopian tube and preparation method thereof.
Background technology
Fallopian tube is the vitals of female reproductive system, at transport sperm, pickup ovum, after making it combination, and is grown by implantation in convey of fertilized ovum to cavity of uterus, is the fertility requisite position of link.So, when fallopian tube occur logical and not smooth or out of shape tortuous cause dysfunction time, sperm will be caused cannot to contact ovum, cause female acyesis; Even if or sperm and ovum
Can be in conjunction with, but germ cell can not arrive in cavity of uterus smoothly, and in fallopian tube implantation, very easily form ectopic pregnancy, serious harm women's health.
A lot of people knows, ectopic pregnancy can cause the hemorrhage and tormina of patients acuity, as treated not in time, then and entail dangers to life.In reality, there are many women to be exactly because ectopic pregnancy causes massive hemorrhage, and have to take operation fallopian tube side is excised, thus reduce the probability of becoming pregnant.
And causing fallopian tube to lead to and not smooth reason has a lot, inflammation infection is arch-criminal.Such as, it is sticky glutinous that Fallopian tube mucosa inflammation can make mucosa fold place occur, makes luminal stenosis, affect germ cell in intraluminal normal operation.After germ cell is hindered, will grow by implantation in tube chamber, cause ectopic pregnancy.
Western medical treatment fallopian tube is logical and smooth, mainly according to the concrete condition at fallopian tube position.In general, for the treatment of interstitial portion and isthmus, in the mode got involved, make not smooth position become unobstructed, become pregnant chance to increase and reduce the occurrence probability of ectopic pregnancy.But the treatment got involved has certain limitation, and the conceived time of postoperative the best is half a year, if also there is no pregnancy in half a year, suspect have again logical and not smooth.
In theory of Chinese medical science, the explanation of salpingemphraxis is qi depression to blood stasis.Qi depression to blood stasis can hinder that punching is appointed, internal organs play its function, and then have influence on the unimpeded of passages through which vital energy circulates, hinders sperm ovum binding.Therefore vital energy regualting and blood circulation-promoting, blood stasis dispelling, siphunculus should be treatment qi depression to blood stasis, the i.e. principles of salpingemphraxis, so need to start with from following 2 when treatment salpingemphraxis.
1, heat-clearing and toxic substances removing, bactericidal antiphlogistic
Chinese traditional treatment salpingemphraxis, with the medicine with heat-clearing and toxic substances removing, can work the effect reaching sterilization like this.Whether patient has infected mycoplasma, gonococcus, S. aureus L-forms, tubercule bacillus etc. by the chemical examination of doctor trained in Western medicine to understand patient, and the medicine of usual Chinese medicine sterilizing antiinflammatory kills various antibacterial, and virus, chlamydia was turned out cloudy at about 3 months.
2, blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating
The traditional Chinese medical science uses the medicine of blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and QI regulating, reduction of patient in various degree can there is the obstacle that microcirculation occurs, improve microcirculatory function, change hemorheology properties, thus impel the absorption of inflammation, slough and disappear, improve the fibrosis of fallopian tube lumen, promote regeneration and the reparation of damage stove inner membrance, be conducive to the unimpeded and functional rehabilitation of fallopian tube.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of obstruction of fallopian tube;
Another object of the present invention is to provide a kind of Chinese medicine composition preparation method for the treatment of obstruction of fallopian tube.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition for the treatment of obstruction of fallopian tube of the present invention, it is prepared from by the raw material comprising following weight portion:
Radix Cudraniae 10-30 part, Hirudo 10-30 part, Radix Salviae Miltiorrhizae 10-30 part, Herba Leonuri 10-30 part, Rhizoma Zingiberis 3-10 part, Squama Manis 10-30 part, Radix Polygalae fallacis 10-30 part, Rhizoma Saururi (Herba Saururi) 10-30 part, Cortex Eucommiae 5-15 part, Rhizoma Polygoni Cuspidati 10-30 part, Radix Angelicae Sinensis 10-30 part, Flos Carthami 10-30 part, Fructus Liquidambaris 10-30 part.
Preferably, be prepared from by the raw material comprising following weight portion:
Radix Cudraniae 15-25 part, Hirudo 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Herba Leonuri 15-25 part, Rhizoma Zingiberis 5-8 part, Squama Manis 15-25 part, Radix Polygalae fallacis 15-25 part, Rhizoma Saururi (Herba Saururi) 15-25 part, Cortex Eucommiae 8-12 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Angelicae Sinensis 15-25 part, Flos Carthami 15-25 part, Fructus Liquidambaris 15-25 part.
Below the crude drug source of Chinese medicine composition of the present invention:
Radix Cudraniae, Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudraniacochinchinensis(Lour.) KudoetMasam., is used as medicine with root.Micro-hardship, flat.Relieving cough and resolving phlegm, expelling wind and removing dampness, eliminating stasis to stop pain.For pulmonary tuberculosis, icterohepatitis, hepatosplenomegaly, taste-blindness rate, rheumatic lumbago and scelalgia; Fracture is controlled in external, traumatic injury.
Hirudo is the dry body of Hirudinidae animal whitmania WhitmaniapigraWhitman, Hirudo HirudonipponicaWhitman or Folium Salicis Babylonicae Hirudo Whit-maniaacranulataWhitman.Salty, bitter, flat; Slightly poisonous.Return Liver Channel.Removing blood stasis, removing blood stasis, stimulates the menstrual flow.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBunge..Hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Herba Leonuri is the fresh or dry aerial parts of labiate Herba Leonuri LeonurusjaponicusHoutt..Bitter, pungent, be slightly cold.Return liver, pericardium channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Rhizoma Zingiberis is the dry rhizome of zingiber ZingiberofficinaleRosc..Pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.
Squama Manis is the scute of Manidae animal Squama Manis ManispentadactylaLinnaeus.Salty, be slightly cold.Return liver, stomach warp.To stimulate the menstrual flow stimulating milk secretion, detumescence and apocenosis, expel wind to dredge collateral.For Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Radix Polygalae fallacis, Polygalaceae polygala Radix Polygalae fallacis PolygalaaureocaudaDunn, is used as medicine with root.Sweet, micro-hardship, flat.Benefiting vital QI and blood, invigorating spleen to remove dampness, promoting blood flow to regulate menstruation.For body is empty after being ill, soreness of waist and knee joint, traumatic injury, icterohepatitis, oedema due to nephritis, uterine prolapse, leucorrhea, menoxenia.
Rhizoma Saururi (Herba Saururi) is Saururaceae plant Rhizoma Saururi (Herba Saururi) Saururuschinensis(Lour.) dry rhizome of Baill. or herb.Sweet, pungent, cold.Return lung, urinary bladder channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.For dysuria, drench the puckery pain of drop, leucorrhea, urinary tract infection, oedema due to nephritis; External treatment sore swollen toxin, eczema.
The Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae EucommiaulmoidesOliv..Sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Rhizoma Polygoni Cuspidati is polygonaceae plant Rhizoma Polygoni Cuspidati PolygonumcuspidatumSieb.etZucc., dry rhizome and root.Micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.Expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Radix Angelicae Sinensis is umbelliferae angelica Angelicasinensis(Oliv.) dry root of Diels.Sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Flos Carthami is the dried floral of feverfew Flos Carthami CarthamustinctoriusL..Pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Fructus Liquidambaris is the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum LiquidambarformosanaHance.Hardship, flat.Return liver, kidney channel.Dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.Concrete preparation method is as follows:
Scheme one: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme two: get whole medical material, uses 40-80% alcohol reflux 2-3 time after mixing, and each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
Scheme three: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.
The Chinese medicine composition for the treatment of obstruction of fallopian tube of the present invention, with pharmaceutically acceptable carrier combination, can also make various oral formulations, as tablet, capsule, oral liquid, syrup, mixture etc.
Pharmaceutically acceptable carrier of the present invention includes but not limited to following:
Oral formulations:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.
Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.
Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.
Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.
Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.
Correctives: sucrose, monosaccharide, aromatic etc.
Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.
Method 1: tablet
Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.
Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 2: capsule
Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into capsule of the present invention routinely.
Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3: syrup
Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.
Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
Method 4: mixture
Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.
Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.
Method 5: oral liquid
Get one of scheme one to scheme three gained active component, dissolve after-purification, concentrate, add oral liquid and commonly use adjuvant, production method is prepared into oral liquid of the present invention routinely.
Above-mentioned oral liquid is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.
The applicant is reference modern pharmacological research achievement on the basis of research tradition tcm syndrome differentiation and treatment, through test for many years, multiple formulations is screened, have found the Chinese medicine formula effectively treating obstruction of fallopian tube, Radix Cudraniae blood circulation promoting and blood stasis dispelling, circulation of qi promoting intestinal stasis relieving in side; Hirudo removing blood stasis; Squama Manis gas raw meat and altering, implements meridians, logical stagnant eliminating stagnation, and be monarch drug altogether, Radix Angelicae Sinensis is the yang aspect of yin medicine, and cooperation Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Polygalae fallacis, Flos Carthami, Fructus Liquidambaris blood-activating and qi-promoting, dissipating blood stasis regulating menstruation, relieving spasm to stop pain is ministerial drug altogether.Rhizoma Saururi (Herba Saururi) heat-clearing and toxic substances removing, Cortex Eucommiae tonifying liver and kidney and strengthening bones and muscles, Rhizoma Polygoni Cuspidati expelling wind and removing dampness is adjuvant drug altogether; Rhizoma Zingiberis warming spleen and stomach for dispelling cold, for making medicine.Full side works in coordination with mutually, has effect of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, and what cure mainly that obstruction of fallopian tube causes is infertile.
A kind of Chinese medicine composition for the treatment of obstruction of fallopian tube provided by the invention has the following advantages:
1, composite preparation provided by the invention is safe and effective, has heat-clearing and toxic substances removing, treating stranguria effect of invigorating blood circulation, and has effect of blood circulation promoting and blood stasis dispelling, dredge the meridian passage, and what cure mainly that obstruction of fallopian tube causes is infertile.
2, prove through clinical trial, patient, after traditional Chinese medicine composition for treating of the present invention, is 91.1% to the total effective rate of kidney obstruction of fallopian tube.
3, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, and mouthfeel is good, and cost is low.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 tablet
Take Radix Cudraniae 1kg, Hirudo 1kg, Radix Salviae Miltiorrhizae 1kg, Herba Leonuri 1kg, Rhizoma Zingiberis 0.3kg, Squama Manis 1kg, Radix Polygalae fallacis 1kg, Rhizoma Saururi (Herba Saururi) 1kg, Cortex Eucommiae 0.5kg, Rhizoma Polygoni Cuspidati 1kg, Radix Angelicae Sinensis 1kg, Flos Carthami 1kg, Fructus Liquidambaris 1kg.Extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 2 tablet
Take Radix Cudraniae 3kg, Hirudo 3kg, Radix Salviae Miltiorrhizae 3kg, Herba Leonuri 3kg, Rhizoma Zingiberis 1kg, Squama Manis 3kg, Radix Polygalae fallacis 3kg, Rhizoma Saururi (Herba Saururi) 3kg, Cortex Eucommiae 1.5kg, Rhizoma Polygoni Cuspidati 3kg, Radix Angelicae Sinensis 3kg, Flos Carthami 3kg, Fructus Liquidambaris 3kg.With 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filter, when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
Embodiment 3 granule
Take Radix Cudraniae 1.5kg, Hirudo 1.5kg, Radix Salviae Miltiorrhizae 1.5kg, Herba Leonuri 1.5kg, Rhizoma Zingiberis 0.5kg, Squama Manis 1.5kg, Radix Polygalae fallacis 1.5kg, Rhizoma Saururi (Herba Saururi) 1.5kg, Cortex Eucommiae 0.8kg, Rhizoma Polygoni Cuspidati 1.5kg, Radix Angelicae Sinensis 1.5kg, Flos Carthami 1.5kg, Fructus Liquidambaris 1.5kg.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, alcohol content is made to be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 4 capsule
Take Radix Cudraniae 2.5kg, Hirudo 2.5kg, Radix Salviae Miltiorrhizae 2.5kg, Herba Leonuri 2.5kg, Rhizoma Zingiberis 0.8kg, Squama Manis 2.5kg, Radix Polygalae fallacis 2.5kg, Rhizoma Saururi (Herba Saururi) 2.5kg, Cortex Eucommiae 1.2kg, Rhizoma Polygoni Cuspidati 2.5kg, Radix Angelicae Sinensis 2.5kg, Flos Carthami 2.5kg, Fructus Liquidambaris 2.5kg.With alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, in extractum, add supplementary product starch, ethanol, dextrin, magnesium stearate, make capsule according to a conventional method.
Embodiment 5 oral liquid
Take Radix Cudraniae 2kg, Hirudo 2kg, Radix Salviae Miltiorrhizae 2kg, Herba Leonuri 2kg, Rhizoma Zingiberis 0.6kg, Squama Manis 2kg, Radix Polygalae fallacis 2kg, Rhizoma Saururi (Herba Saururi) 2kg, Cortex Eucommiae 1kg, Rhizoma Polygoni Cuspidati 2kg, Radix Angelicae Sinensis 2kg, Flos Carthami 2kg, Fructus Liquidambaris 2kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, adds adjuvant mannitol, sorbic acid, water stirs in extractum, subpackage, obtained oral liquid.
Embodiment 6 granule
Take Radix Cudraniae 1.8kg, Hirudo 2kg, Radix Salviae Miltiorrhizae 1.5kg, Herba Leonuri 1.5kg, Rhizoma Zingiberis 0.7kg, Squama Manis 1.2kg, Radix Polygalae fallacis 1.5kg, Rhizoma Saururi (Herba Saururi) 2kg, Cortex Eucommiae 0.8kg, Rhizoma Polygoni Cuspidati 1.2kg, Radix Angelicae Sinensis 2kg, Flos Carthami 1.8kg, Fructus Liquidambaris 1.5kg.Extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, and each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filter, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, adds ethanol, alcohol content is made to be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 70 DEG C, relative density is the extractum of 1.25, add starch, dextrin, granulate, dry, granulate and get final product.
Embodiment 7 syrup
Take Radix Cudraniae 1.2kg, Hirudo 1.2kg, Radix Salviae Miltiorrhizae 1.2kg, Herba Leonuri 1.2kg, Rhizoma Zingiberis 0.4kg, Squama Manis 1.2kg, Radix Polygalae fallacis 1.2kg, Rhizoma Saururi (Herba Saururi) 1.2kg, Cortex Eucommiae 0.6kg, Rhizoma Polygoni Cuspidati 1.2kg, Radix Angelicae Sinensis 1.2kg, Flos Carthami 1.2kg, Fructus Liquidambaris 1.2kg.Extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.
Embodiment 8 mixture
Take Radix Cudraniae 1.8kg, Hirudo 1.8kg, Radix Salviae Miltiorrhizae 1.8kg, Herba Leonuri 1.8kg, Rhizoma Zingiberis 0.7kg, Squama Manis 1.8kg, Radix Polygalae fallacis 1.8kg, Rhizoma Saururi (Herba Saururi) 1.8kg, Cortex Eucommiae 1.2kg, Rhizoma Polygoni Cuspidati 1.8kg, Radix Angelicae Sinensis 1.8kg, Flos Carthami 1.8kg, Fructus Liquidambaris 1.8kg.Extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, filtrate is concentrated into 3 times that gross weight is medical material gross weight, fill, add mixture adjuvant sucrose, ethyl ester, water, sorbic acid stir, obtained mixture.
Embodiment 9 powder
Take Radix Cudraniae 1.2kg, Hirudo 1.5kg, Radix Salviae Miltiorrhizae 1.8kg, Herba Leonuri 2.2kg, Rhizoma Zingiberis 0.7kg, Squama Manis 2.5kg, Radix Polygalae fallacis 1kg, Rhizoma Saururi (Herba Saururi) 2kg, Cortex Eucommiae 0.9kg, Rhizoma Polygoni Cuspidati 1.5kg, Radix Angelicae Sinensis 1.8kg, Flos Carthami 1.2kg, Fructus Liquidambaris 2kg.Pulverize, sieve, to obtain final product.
clinical trial
1 physical data
Observe 56 routine patients, all through radiography or hydrotubation inspection, bilateral obstructed person 12 example, one-sided obstructed person 25 example, bilateral or one-sided logical and impassable patient 19 is routine.
2 evaluation criterias
Recovery from illness: clinical symptom disappearance, hydrotubation non-resistance;
Take a turn for the better: clinical symptom disappearance, hydrotubation is resistance slightly;
Invalid: clinical symptoms partial disappearance, hydrotubation resistance is larger.
3 Therapeutic Method
Give the embodiment of the present invention 5 oral liquid treatment, each 10ml, premenstrual through after respectively serve on 4 days, be 1 course for the treatment of.
4 results
Through the treatment of three courses for the treatment of, clinical efficacy is in table 1.
Table 1 the present invention treats the clinical efficacy of obstruction of fallopian tube
n Recovery from illness Take a turn for the better Invalid Total effective rate (%)
Curative effect 56 20 31 5 91.1
As shown in Table 1, after the treatment of two courses for the treatment of, the present invention is 92.5% to the total effective rate of obstruction of fallopian tube.Result shows: Chinese medicine composition of the present invention has good therapeutical effect to obstruction of fallopian tube.
model case
Lee X, 32 years old.3 years after marriage unpregnancies.Patient is normal for menstrual period, and color purple is dark red, and amount is few, and companion's lower abdominal pain, the soreness of waist, bitter taste in the mouth and dry throat, purplish tongue, yellow and thin fur, the tip of the tongue have tired blood point, deep and stringy pulse.Gynaecological examination: vagina uterine no abnormality seen, looks into fallopian tube bilateral obstructed, gives the embodiment of the present invention 4 and treats 4 courses for the treatment of and pregnant.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (7)

1. treat a Chinese medicine composition for obstruction of fallopian tube, it is characterized in that it is made up of the raw material of Chinese medicine comprising following weight portion:
Radix Cudraniae 10-30 part, Hirudo 10-30 part, Radix Salviae Miltiorrhizae 10-30 part, Herba Leonuri 10-30 part, Rhizoma Zingiberis 3-10 part, Squama Manis 10-30 part, Radix Polygalae fallacis 10-30 part, Rhizoma Saururi (Herba Saururi) 10-30 part, Cortex Eucommiae 5-15 part, Rhizoma Polygoni Cuspidati 10-30 part, Radix Angelicae Sinensis 10-30 part, Flos Carthami 10-30 part, Fructus Liquidambaris 10-30 part.
2. the Chinese medicine composition for the treatment of obstruction of fallopian tube as claimed in claim 1, is characterized in that it is made up of the raw material of Chinese medicine comprising following weight portion:
Radix Cudraniae 15-25 part, Hirudo 15-25 part, Radix Salviae Miltiorrhizae 15-25 part, Herba Leonuri 15-25 part, Rhizoma Zingiberis 5-8 part, Squama Manis 15-25 part, Radix Polygalae fallacis 15-25 part, Rhizoma Saururi (Herba Saururi) 15-25 part, Cortex Eucommiae 8-12 part, Rhizoma Polygoni Cuspidati 15-25 part, Radix Angelicae Sinensis 15-25 part, Flos Carthami 15-25 part, Fructus Liquidambaris 15-25 part.
3. the Chinese medicine composition for the treatment of obstruction of fallopian tube as claimed in claim 1 or 2, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
4. the Chinese medicine composition for the treatment of obstruction of fallopian tube as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
5. the Chinese medicine composition for the treatment of obstruction of fallopian tube as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, 40-80% alcohol reflux 2-3 time is used after mixing, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, obtains active component.
6. the Chinese medicine composition for the treatment of obstruction of fallopian tube as claimed in claim 3, it is characterized in that its active component is prepared from by the following method: get whole medical material, extracting in water 2-3 time after mixing, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.15-1.20, add ethanol, alcohol content is made to be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtain active component.
7. treat a Chinese medicine composition for obstruction of fallopian tube, be prepared from by the Chinese medicine composition of the treatment obstruction of fallopian tube described in claim 1 or 2 and pharmaceutically acceptable carrier combination.
CN201510838690.2A 2015-11-27 2015-11-27 Traditional Chinese medicine composition for treating tubal nowhere and preparation method thereof Pending CN105412861A (en)

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