CN103585597A - Traditional Chinese medicine composition for relieving severe pain caused by renal calculus - Google Patents
Traditional Chinese medicine composition for relieving severe pain caused by renal calculus Download PDFInfo
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- CN103585597A CN103585597A CN201310488734.4A CN201310488734A CN103585597A CN 103585597 A CN103585597 A CN 103585597A CN 201310488734 A CN201310488734 A CN 201310488734A CN 103585597 A CN103585597 A CN 103585597A
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Abstract
The invention relates to a traditional Chinese medicine composition for relieving severe pain caused by renal calculus, belonging to the technical field of Chinese medicinal herbs. The composition is composed of the following active pharmaceutical ingredients in parts by weight: 25-35 parts of deer's horn deglued, 10-20 parts of cassia twig, 95-105 parts of Herba Lysimachiae, 15-25 parts of radix astragali, 15-25 parts of radix clematidis, 15-25 parts of chickens gizzard-skin, 5-15 parts of Reed Rhizome, 5-10 parts of dried ginger, 5-15 parts of rhubarb and 25-25 parts of malva seed. The composition has the characteristics of accessible materials, simple manufacturing process, low cost, high practicality, small dosage, low content of harmful ingredients, no toxic or side effect, obvious curative effect and the like.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind ofly for alleviating, cause the Chinese medicine composition having an intense pain because of renal calculus.
Background technology
Renal calculus as its name suggests, is exactly that kidney the inside has grown " stone ".In each organ of urinary system, the normally lithogenous position of kidney.Renal calculus is one of common disease of urinary system, in every 20 people, just has one may suffer from renal calculus.Known renal calculus composition has tens of kinds.Conventionally calculus is divided into four large classes clinically: containing calcium calculus, Infective calculus, urate calculus and cystine stone.The cause of disease of renal calculus is a lot, has hereditary factors, metabolic factor, infectious factors, environmental factors, dietary factor, anatomical factors, medicine factor etc.Although renal calculus is a kind of benign disease, sometimes may stop up the discharge that urinary tract hinders urine, cause pain, hydronephrosis, serious may cause even tumor of uremia.The pain causing for renal calculus at present mainly relies on medical respite pain, but Western medicine has the shortcomings such as side effect is large.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of cure rate high, safe and reliable for alleviating, causes the Chinese medicine composition having an intense pain because of renal calculus.
Technical problem to be solved by this invention realizes by the following technical solutions:
For alleviating because renal calculus causes the Chinese medicine composition having an intense pain, the medicament of being made by the crude drug of following weight portion,
Cornu Cervi Degelatinatum 25-35 part, Ramulus Cinnamomi 10-20 part, Herba Lysimachiae 95-105 part, Radix Astragali 15-25 part, Radix Clematidis 15-25 part, Endothelium Corneum Gigeriae Galli 15-25 part, Rhizoma Phragmitis 5-15 part, Rhizoma Zingiberis 5-10 part, Radix Et Rhizoma Rhei 5-15 part, Semen Abutili 25-25 part.
Preferred weight part of each crude drug is:
30 parts of Cornu Cervi Degelatinatums, 15 parts of Ramulus Cinnamomi, 100 parts of Herba Lysimachiaes, 20 parts of the Radixs Astragali, 20 parts of Radix Clematidis, 20 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Phragmitiss, 5 parts of Rhizoma Zingiberiss, 10 parts of Radix Et Rhizoma Rhei, 30 parts of Semen Abutilis.
The present invention's crude drug used can be bought and obtain from common Chinese shop, and its specification meets national Chinese crude drug standard.
Chinese medicine composition of the present invention can add various adjuvants required while preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., with conventional method of Chinese medicinal, be prepared into any conventional oral formulations, wherein, described oral formulations can be decoction, pill, capsule or tablet.
Another object of the present invention is to provide a kind of method of preparing the present composition, comprises the steps,
1) by following parts by weight, take each crude drug: 30 parts of Cornu Cervi Degelatinatums, 15 parts of Ramulus Cinnamomi, 100 parts of Herba Lysimachiaes, 20 parts of the Radixs Astragali, 20 parts of Radix Clematidis, 20 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Phragmitiss, 5 parts of Rhizoma Zingiberiss, 30 parts of Semen Abutilis.
2) above-mentioned each taste material medicine is mixed be placed on and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, add Radix Et Rhizoma Rhei to renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, can in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains pill, capsule or tablet.
Usage and consumption:
The dosage of medicine of the present invention depends on concrete dosage form, and the factor such as age of patient, body weight, health status.
Instruction: decoction, get a pair and take herb liquid, each oral 120-150 milliliter, one day twice, sub-service sooner or later, 1 day was a course for the treatment of; Pill or capsule or tablet, two ball/grain/sheets once, twice, 1 day on the one is a course for the treatment of.
Pharmacology analysis:
Cornu Cervi Degelatinatum: salty, temperature.Return liver, kidney channel.Warming the kidney to activate YANG, astringing to arrest bleeding.For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule.
Ramulus Cinnamomi: acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.
Herba Lysimachiae: there is heat clearing away, dampness removing, detumescence, removing toxic substances.The subcutaneous ulcer of harnessing the Yellow River, edema, cholelithiasis, renal calculus, vesical calculus, regurgitation is dysphagic, traumatic injury, the effect of furuncle swelling toxin.
The Radix Astragali: there is the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.
Radix Clematidis: for expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.
Endothelium Corneum Gigeriae Galli: sweet, cold.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach is aid digestion, arresting seminal emission.Can promote gastric secretion, improve gastric acidity and eupepsy, stomach motor function obviously be strengthened, rapid gastric emptying.
Rhizoma Phragmitis: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Rhizoma Zingiberis: acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.
Radix Et Rhizoma Rhei: have and attack the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.
Semen Abutili: row neatly intestinal, lactogenesis, clearing away heat and discharging pus.
Medicated diet prepared by the present invention has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and treatment disease, and the use link that this medicine is dropped into treatment disease provides science and objective foundation.Its test method and result of the test are as follows respectively:
1. the medicated diet that couple the present invention boils carries out animal acute toxicity test:
Medicine: the decoction being boiled by prescription of the present invention, saving backup ，You The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine in refrigerator provides.
Experimental animal: white mice, body weight is at 30-50g, and male and female select ，You Medical University Of Anhui to provide at random.
Method and result: get 50 of white mice, be divided into 5 groups, 10 every group, hungry about 15 hours, by every each 20ml, fill with medicine feed thing, in 24 hours, fill with respectively medicine feed thing 1,2,3,4,5 times, observe 5 days for the 1st, 2,3,4,5 groups, white mice is movable normal, and non-toxic reaction, without dead.Wherein white mice dosage is calculated by kg body weight dose, shows that oral liquid is without acute toxicity, clinical medicine dose safety.
2. the decoction that couple the present invention boils carries out long-term toxicity test for animals:
Experimental animal: rat, body weight, at 120-130g, all selects male white rat ，You Medical University Of Anhui to provide.
Method and result: get 50 of rat, be divided into 5 groups, every group 10, wherein the 1st, 2, 3, 4 groups as administration group, fill with respectively medicine feed thing 15ml for every group, 20ml, 30ml, 40ml, the 5th group of normal feeding as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the variation of tissues observed form, observe the effect of dosage, observe diet, movable variation, experimental results show that administration group and matched group are relatively without significant change, the visible kg body weight of pressing is calculated the equal non-toxic reaction of dosage doubly with respect to clinical 50-200, a kind of safe drugs.
3. diagnostic criteria
1) symptom and sign: suffer from renal calculus, occur having an intense pain.
2) in order to verify clinical efficacy, this prescription is tried out in First Attached Hospital, Anhui Medical Univ. and The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine respectively, and by choosing at random wherein 100 routine patients, the course for the treatment of is the shortest 1 day, and the longest is 3 days.
3) Therapeutic Method
According to drug ratios of the present invention, take raw material (dosage), according to the method for conventionally boiling medicine, obtain medicinal liquid, every day, potion, serviced once sooner or later, and taking 1 day is a course for the treatment of.
4) efficacy determination: adopt level Four standard;
Recovery from illness clinical improvements rate >=5%, effective clinical improvements rate >=72%, effective clinical improvement rate >=22%, invalid clinical improvements rate >=1%, concrete therapeutic outcome is referring to table 1.
Table 1
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effective percentage (%) |
| 100 | 5 | 72 | 22 | 1 | 99 |
The invention has the beneficial effects as follows: the present invention draws materials easily, makes the features such as simple, with low cost, practicality is good, and taking dose is little, and Harmful ingredient content is low, has no side effect, evident in efficacy.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
By following parts by weight, take each crude drug: 30 parts of Cornu Cervi Degelatinatums, 15 parts of Ramulus Cinnamomi, 100 parts of Herba Lysimachiaes, 20 parts of the Radixs Astragali, 20 parts of Radix Clematidis, 20 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Phragmitiss, 5 parts of Rhizoma Zingiberiss, 10 parts of Radix Et Rhizoma Rhei, 30 parts of Semen Abutilis.
Above-mentioned each taste material medicine is mixed to be placed on except Radix Et Rhizoma Rhei in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, add Radix Et Rhizoma Rhei to renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction.Instruction: decoction, get a pair and take herb liquid, each oral 150 milliliters, one day twice, sub-service sooner or later, 1 day was a course for the treatment of.
Embodiment 2
By following parts by weight, take each crude drug: 25 parts of Cornu Cervi Degelatinatums, 10 parts of Ramulus Cinnamomi, 95 parts of Herba Lysimachiaes, 15 parts of the Radixs Astragali, 15 parts of Radix Clematidis, 15 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Phragmitiss, 5 parts of Rhizoma Zingiberiss, 5 parts of Radix Et Rhizoma Rhei, 25 parts of Semen Abutilis.
Above-mentioned each taste material medicine is mixed to be placed on except Radix Et Rhizoma Rhei and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, add Radix Et Rhizoma Rhei to renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains capsule.Within 1st, take twice, each 2, sub-service sooner or later, 1 day is a course for the treatment of.
Embodiment 3
By following parts by weight, take each crude drug: 35 parts of Cornu Cervi Degelatinatums, 20 parts of Ramulus Cinnamomi, 105 parts of Herba Lysimachiaes, 25 parts of the Radixs Astragali, 25 parts of Radix Clematidis, 25 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Rhizoma Phragmitiss, 0 part of Rhizoma Zingiberis, 15 parts of Radix Et Rhizoma Rhei, 25 parts of Semen Abutilis.
Above-mentioned each taste material medicine is mixed to be placed on except Radix Et Rhizoma Rhei in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, add Radix Et Rhizoma Rhei to renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains pill, within 1st, take twice, each 2 balls, sub-service sooner or later, 1 day is a course for the treatment of.
Embodiment 4
By following parts by weight, take each crude drug: 35 parts of Cornu Cervi Degelatinatums, 20 parts of Ramulus Cinnamomi, 100 parts of Herba Lysimachiaes, 25 parts of the Radixs Astragali, 25 parts of Radix Clematidis, 15 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Rhizoma Phragmitiss, 5 parts of Rhizoma Zingiberiss, 5 parts of Radix Et Rhizoma Rhei, 25 parts of Semen Abutilis.
Above-mentioned each taste material medicine is mixed to be placed on except Radix Et Rhizoma Rhei and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, add Radix Et Rhizoma Rhei to renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains using capsule; Instruction: decoction, get a pair and take herb liquid, each oral 150 milliliters, one day twice, sub-service sooner or later, 1 day was a course for the treatment of.
Model case
Case 1
High certain ，Nan ，32Sui， working people.Suffer from renal calculus existing 2 years, hurt like hell all while at every turn falling ill, cannot work.After when its pain, take capsule prepared by the present invention, take one day pain and disappeared, after taken continuously a week again, follow up a case by regular visits to so far substantially pain and do not occur.
Case 2
Revive so-and-so, man, 28 years old, suffer from renal calculus, the calculus that always has Western medicine, but all do not have to remove totally through bimestrial treatment, pain often occurs.Take the decoction that the present invention boils, occur calculus phenomenon after 7 days, pain slowly disappears; After take continuously again 7 days, follow up a case by regular visits to pain so far and remain dormant.
Case 3
Together so-and-so, female, 45 years old, suffer from renal calculus, once morbidity, hurt like hell, all will arrive hospital transfusion at every turn and treat.Take the decoction that the present invention boils, occur calculus phenomenon after 7 days, pain slowly disappears, and through looking into, calculus is got rid of totally substantially; After take continuously again 7 days, follow up a case by regular visits to pain so far and remain dormant.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; that in above-described embodiment and description, describes just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.The claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (7)
1. for alleviating because renal calculus causes the Chinese medicine composition having an intense pain, it is characterized in that: the medicament of being made by the crude drug of following weight portion,
Cornu Cervi Degelatinatum 25-35 part, Ramulus Cinnamomi 10-20 part, Herba Lysimachiae 95-105 part, Radix Astragali 15-25 part, Radix Clematidis 15-25 part, Endothelium Corneum Gigeriae Galli 15-25 part, Rhizoma Phragmitis 5-15 part, Rhizoma Zingiberis 5-10 part, Radix Et Rhizoma Rhei 5-15 part, Semen Abutili 25-25 part.
2. according to claim 1 a kind of for alleviating because renal calculus causes the Chinese medicine composition having an intense pain, it is characterized in that: the medicament of being made by the crude drug of following weight portion,
30 parts of Cornu Cervi Degelatinatums, 15 parts of Ramulus Cinnamomi, 100 parts of Herba Lysimachiaes, 20 parts of the Radixs Astragali, 20 parts of Radix Clematidis, 20 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Phragmitiss, 5 parts of Rhizoma Zingiberiss, 10 parts of Radix Et Rhizoma Rhei, 30 parts of Semen Abutilis.
3. according to claim 1 and 2 a kind of for alleviating because renal calculus causes the Chinese medicine composition having an intense pain, it is characterized in that: described medicament is any suitable preparation clinically.
4. according to claim 3 a kind of for alleviating because renal calculus causes the Chinese medicine composition having an intense pain, it is characterized in that: described preparation is oral formulations.
5. according to claim 4 a kind of for alleviating because renal calculus causes the Chinese medicine composition having an intense pain, it is characterized in that: described oral formulations is decoction or capsule or pill or tablet.
6. prepare a kind of for alleviating a method that causes the Chinese medicine composition having an intense pain because of renal calculus described in claim 1 or 2 any one, it is characterized in that: comprise the following steps,
A. by described weight portion, take each taste crude drug;
B. above-mentioned each taste material medicine is mixed to be placed on and in marmite, add water and do not have powder, soak after 20～40 minutes, with slow fire boiling, after boiling, add Radix Et Rhizoma Rhei to renew and decoct 30 minutes, decoct altogether three times, merge three decocting liquids and filter, obtain decoction, can in decoction, add after the conventional adjuvant of preparation or carrier, preparations shaping, obtains pill, capsule or tablet.
7. the purposes in treatment renal calculus medicine according to the Chinese medicine composition described in claim 1 or 2 any one.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106511395A (en) * | 2016-11-30 | 2017-03-22 | 四川旭华制药有限公司 | Traditional Chinese medicine composition for fast treating kidney stone |
| CN107692192A (en) * | 2016-08-08 | 2018-02-16 | 李艳青 | Formula of kidney stone pain and preparation method thereof is alleviated in a kind of dietotherapy |
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| CN101549113A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating urinary system stones and preparation method thereof |
| CN102872437A (en) * | 2012-09-27 | 2013-01-16 | 强红兵 | Special-disease calculus-removing decoction for treating renal calculus |
| CN103142752A (en) * | 2013-02-08 | 2013-06-12 | 安耀苍 | Urinary calculus treatment medicine and its preparation method |
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2013
- 2013-10-18 CN CN201310488734.4A patent/CN103585597B/en not_active Expired - Fee Related
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| CN101549113A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating urinary system stones and preparation method thereof |
| CN102872437A (en) * | 2012-09-27 | 2013-01-16 | 强红兵 | Special-disease calculus-removing decoction for treating renal calculus |
| CN103142752A (en) * | 2013-02-08 | 2013-06-12 | 安耀苍 | Urinary calculus treatment medicine and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107692192A (en) * | 2016-08-08 | 2018-02-16 | 李艳青 | Formula of kidney stone pain and preparation method thereof is alleviated in a kind of dietotherapy |
| CN106511395A (en) * | 2016-11-30 | 2017-03-22 | 四川旭华制药有限公司 | Traditional Chinese medicine composition for fast treating kidney stone |
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