CN101549113A - Traditional Chinese medicine composition for treating urinary system stones and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating urinary system stones. The traditional Chinese medicine composition is prepared by longhairy antenoron herb, Japanese climbing fern spore, clematis root, cassia seed, chicken's gizzard-membrane, officinal magnolia bark, reed rhizome, Chinese thorowax root, giant knotweed rhizome, talc, bitter orange, virgate wormwood herb, rhubarb, pyrrosia leaf, cluster mallow fruit, medicinal cyathula root and/or a pharmaceutically acceptable carrier. The invention further relates to a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the efficacies of clearing heat, promoting diuresis, invigorating spleen and kidney, removing dampness, relieving masses, regulating qi, activating stagnancy, softening hardness, resolving stones, treating stranguria and expelling stones and is used for treating kidney stones, gall-stones, ureteral stones, bladder stones and the like.

Description

A kind of Chinese medicine composition for the treatment of urinary system calculus and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of urinary system calculus and preparation method thereof.

Background technology

Calculus is in the catheter lumen or chamber sexual organ's (as gallbladder, bladder) chamber in the solid mass that forms.Be mainly seen in gallbladder and bladder, the renal pelvis, also be found in the chamber of pancreas conduit, glandula conduit etc., can cause tube chamber to block, the get involved discharge of organ liquid of influence produces symptoms such as pain, hemorrhage or infection.Calculus is made up of inorganic salt or Organic substance.One core is normally arranged in the calculus, be made up of the epithelial cell that comes off, bacterial aggregate, parasitic ovum or polypide, excrement piece or foreign body, inorganic salt or Organic substance deposit on the core more layer by layer.The difference of organ owing to get involved, the contained composition of lithogenous mechanism, shape, quality, all inequality to the influence of body etc.Common calculus has cholelithiasis, vesical calculus, ureteral calculus, pancreas catheter calculus, calculus of salivary duct, appendiceal fecalith, gastrolith, foreskin stone and tartar etc.

Urinary system calculus is the general designation of position calculus such as kidney, ureter, bladder and urethra, is one of common disease of urinary system.The urinary system calculus majority is primary in kidney and bladder, and ureteral calculus often is secondary to renal calculus, due to calculus of urethra is blocked when the intravesical calculus is gone out with urine stream often.Kidney, ureteral calculus are about 5.5～6: 1 with bladder, calculus of urethra ratio.The incidence rate male of urinary system calculus is higher than the women, and kidney and ureteral calculus are more common in 20～40 years old person between twenty and fifty, accounts for about 70%; Bladder and calculus of urethra mostly occur child below 10 years old and the gerontal patient more than 50 years old.After urinary system calculus causes urinary tract obstruction and infects, bigger to renal function injury, block for a long time with lower urinary tract especially and solitary kidney when blocking, even more serious to systemic effects, also complicated in the processing, but the severe patient threat to life.

Pathological lesion that calculus of urinary system causes and pathophysiological change mainly contain following three kinds:

(1) directly infringement

Urinary calculi can cause urinary tract mucosa hyperemia, edema, ulceration, hemorrhage, and the secular chronic stimulation of calculus also can cause the possibility of urothelium canceration sometimes.

(2) block

Last lithangiuria often causes urine stream to block and cause hydronephrosis and dilatation of ureter, infringement nephridial tissue and function thereof.Bladder and calculus of urethra can cause dysuria or urine retention, also can cause bilateral dilatation of ureter, kidney hydrops in the course of time, the infringement renal function.

(3) infect

Urinary calculi when particularly causing urinary tract obstruction, infects then easier generation with infection to uroepithelial direct infringement is many, infects severe patient and can cause pyelonephritis, pyonephrosis and perinephritis.

Calculus, block and infect three's reciprocal causation, impel pathological development.Calculus causes blocks, and blocks and brings out infection, infects and facilitates calculus again, increases the weight of to block, and finally destroys nephridial tissue, the infringement renal function.

The traditional Chinese medical science thinks that urinary system calculus belongs to " stranguria caused by urinary stone " category." stranguria caused by urinary stone person, drench and go out stone also ", damp-heat in lower-JIAO pents up into stone.Patient shows as dysurea, urine color muddiness or color, lumbago, companion's frequent micturition, urgent micturition.Yellow, greasy and thin fur, the lubricated number of arteries and veins.

Clinical excess syndrome and the syndrome of intermingled deficiency and excess of often being divided into:

(1) excess syndrome type, burning into sand stone when disease is seen in the urine, it is involved and abstruse to urinate, or interrupts suddenly when urinating, the poverty-stricken pain of urethra, cramp and pain in the lower abdomen, or the waist angina abdominis is unbearably, is with blood in the urine, red tongue, yellow and thin fur, stringy pulse or band number.Control suitable clearing away heat-damp and promoting diuresis, Tonglin Paishi, cooling blood for hemostasis.

(2) simulataneous insufficiency and excessive type, disease see that disease sandstone of a specified duration does not go, and can accompany and see spiritlessness and weakness, down in spirits, the few China of pallor, light red tongue has indentation, thready and weak pulse without strength, or companion's waist abdomen has a dull ache soreness of the waist and knees, feverish sensation in the palms and soles, hectic fever, night sweat, spiritlessness and weakness, the few tongue of red tongue, pulse condition is counted accurately.It is treating stranguria to control suitable diuresis and expelling stone, or double benefiting vital QI and blood, or double vital essence replenishing.

The traditional Chinese medical science adopts clearing away heat-damp and promoting diuresis, strengthening spleen, tonifying kidney, removing dampness to remove loose this disease of decoction for the treatment of stone, Tonglin Paishi of long-pending, regulating qi-flowing for activating stagnancy, softening the hard mass.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of urinary system calculus.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of urinary system calculus, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Herba Lysimachiae 10-20 part Spora Lygodii 15-20 part Radix Clematidis 5-10 part

Semen Cassiae 20-30 part Endothelium Corneum Gigeriae Galli 10-15 part Cortex Magnoliae Officinalis 20-25 part

Rhizoma Phragmitis 10-20 part Radix Bupleuri 20-30 part Rhizoma Polygoni Cuspidati 20-30 part

Talcum 10-15 part Fructus Aurantii 25-35 part Herba Artemisiae Scopariae 15-25 part

Radix Et Rhizoma Rhei 10-15 part Folium Pyrrosiae 20-25 part Semen Abutili 10-20 part

Radix Cyathulae 20-30 part

Effective ingredient is preferably made by weight by following raw materials according:

8 parts of 18 parts of Radix Clematidis of 16 parts of Spora Lygodii of Herba Lysimachiae

23 parts of 13 parts of Cortex Magnoliae Officinalis of 26 parts of Endothelium Corneum Gigeriae Galli of Semen Cassiae

26 parts of 26 parts of Rhizoma Polygoni Cuspidati of 16 parts of Radix Bupleuri of Rhizoma Phragmitis

20 parts of 30 portions of Herba Artemisiae Scopariaes of 13 parts of Fructus Aurantiis of Talcum

15 parts of 23 parts of Semen Abutilis of 13 parts of Folium Pyrrosiaes of Radix Et Rhizoma Rhei

26 parts of Radix Cyathulaes

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) Talcum, that Rhizoma Phragmitis is ground into impalpable powder is standby;

(2) Cortex Magnoliae Officinalis, Radix Bupleuri, Herba Artemisiae Scopariae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Lysimachiae, Spora Lygodii, Radix Clematidis, Semen Cassiae, Endothelium Corneum Gigeriae Galli, Rhizoma Polygoni Cuspidati, Fructus Aurantii, Radix Et Rhizoma Rhei, Folium Pyrrosiae, Semen Abutili, Radix Cyathulae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has clearing away heat-damp and promoting diuresis, strengthening spleen, tonifying kidney, removing dampness and removes the loose effect of stone, Tonglin Paishi of long-pending, regulating qi-flowing for activating stagnancy, softening the hard mass, is used for diseases such as renal calculus, cholelithiasis, ureteral calculus and vesical calculus.

The specific embodiment:

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1: Chinese medicinal composition granules of the present invention

(1) Talcum 130g, that Rhizoma Phragmitis 200g is ground into impalpable powder is standby;

(2) Cortex Magnoliae Officinalis 230g, Radix Bupleuri 260g, Herba Artemisiae Scopariae 200g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Lysimachiae 160g, Spora Lygodii 180g, Radix Clematidis 80g, Semen Cassiae 260g, Endothelium Corneum Gigeriae Galli 130g, Rhizoma Polygoni Cuspidati 260g, Fructus Aurantii 300g, Radix Et Rhizoma Rhei 130g, Folium Pyrrosiae 230g, Semen Abutili 150g, Radix Cyathulae 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 900g, lactose 400g, mixing, with 70% ethanol wet granulation promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) Talcum 130g, that Rhizoma Phragmitis 200g is ground into impalpable powder is standby;

(2) Cortex Magnoliae Officinalis 230g, Radix Bupleuri 260g, Herba Artemisiae Scopariae 200g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Lysimachiae 160g, Spora Lygodii 180g, Radix Clematidis 80g, Semen Cassiae 260g, Endothelium Corneum Gigeriae Galli 130g, Rhizoma Polygoni Cuspidati 260g, Fructus Aurantii 300g, Radix Et Rhizoma Rhei 130g, Folium Pyrrosiae 230g, Semen Abutili 150g, Radix Cyathulae 260g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 720g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) Talcum 130g, that Rhizoma Phragmitis 200g is ground into impalpable powder is standby;

(2) Cortex Magnoliae Officinalis 230g, Radix Bupleuri 260g, Herba Artemisiae Scopariae 200g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Lysimachiae 160g, Spora Lygodii 180g, Radix Clematidis 80g, Semen Cassiae 260g, Endothelium Corneum Gigeriae Galli 130g, Rhizoma Polygoni Cuspidati 260g, Fructus Aurantii 300g, Radix Et Rhizoma Rhei 130g, Folium Pyrrosiae 230g, Semen Abutili 150g, Radix Cyathulae 260g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, tabletting, coating are promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of urinary system calculus is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Herba Lysimachiae 10-20 part Spora Lygodii 15-20 part Radix Clematidis 5-10 part

Semen Cassiae 20-30 part Endothelium Corneum Gigeriae Galli 10-15 part Cortex Magnoliae Officinalis 20-25 part

Rhizoma Phragmitis 10-20 part Radix Bupleuri 20-30 part Rhizoma Polygoni Cuspidati 20-30 part

Talcum 10-15 part Fructus Aurantii 25-35 part Herba Artemisiae Scopariae 15-25 part

Radix Et Rhizoma Rhei 10-15 part Folium Pyrrosiae 20-25 part Semen Abutili 10-20 part

Radix Cyathulae 20-30 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

8 parts of 18 parts of Radix Clematidis of 16 parts of Spora Lygodii of Herba Lysimachiae

23 parts of 13 parts of Cortex Magnoliae Officinalis of 26 parts of Endothelium Corneum Gigeriae Galli of Semen Cassiae

26 parts of 26 parts of Rhizoma Polygoni Cuspidati of 16 parts of Radix Bupleuri of Rhizoma Phragmitis

20 parts of 30 portions of Herba Artemisiae Scopariaes of 13 parts of Fructus Aurantiis of Talcum

15 parts of 23 parts of Semen Abutilis of 13 parts of Folium Pyrrosiaes of Radix Et Rhizoma Rhei

26 parts of Radix Cyathulaes.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) Talcum, that Rhizoma Phragmitis is ground into impalpable powder is standby;

(2) Cortex Magnoliae Officinalis, Radix Bupleuri, Herba Artemisiae Scopariae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Herba Lysimachiae, Spora Lygodii, Radix Clematidis, Semen Cassiae, Endothelium Corneum Gigeriae Galli, Rhizoma Polygoni Cuspidati, Fructus Aurantii, Radix Et Rhizoma Rhei, Folium Pyrrosiae, Semen Abutili, Radix Cyathulae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.