CN103341071B - Traditional Chinese medicine composition for treating canine and feline urocystitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating canine and feline urocystitis and preparation method thereof Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 30
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 241000282465 Canis Species 0.000 title abstract 3
- 241000282324 Felis Species 0.000 title abstract 3
- 239000002994 raw material Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 201000003146 cystitis Diseases 0.000 claims description 16
- 241000282326 Felis catus Species 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 15
- 238000009835 boiling Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000454 talc Substances 0.000 abstract description 6
- 229910052623 talc Inorganic materials 0.000 abstract description 6
- 235000012222 talc Nutrition 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 3
- 239000008280 blood Substances 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 208000004880 Polyuria Diseases 0.000 abstract description 2
- 230000035619 diuresis Effects 0.000 abstract description 2
- 210000004185 liver Anatomy 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 238000005728 strengthening Methods 0.000 abstract description 2
- 244000281702 Dioscorea villosa Species 0.000 abstract 2
- 241000146029 Lindera aggregata Species 0.000 abstract 2
- 240000003915 Lophatherum gracile Species 0.000 abstract 2
- 241000612166 Lysimachia Species 0.000 abstract 2
- 241001116757 Pyrrosia lingua Species 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 description 12
- 210000003932 urinary bladder Anatomy 0.000 description 10
- 230000003203 everyday effect Effects 0.000 description 6
- 230000036760 body temperature Effects 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 208000006750 hematuria Diseases 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 206010011793 Cystitis haemorrhagic Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000006568 Urinary Bladder Calculi Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 201000002802 hemorrhagic cystitis Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002559 palpation Methods 0.000 description 2
- 239000004576 sand Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000005070 sphincter Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 239000004254 Ammonium phosphate Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010063057 Cystitis noninfective Diseases 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 1
- 235000019289 ammonium phosphates Nutrition 0.000 description 1
- FOFYPMPFTYORPL-UHFFFAOYSA-N azanium;2,8-dioxo-7,9-dihydro-3h-purin-6-olate Chemical compound N.N1C(=O)NC(=O)C2=C1NC(=O)N2 FOFYPMPFTYORPL-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229960001732 pipemidic acid Drugs 0.000 description 1
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- 230000003202 urodynamic effect Effects 0.000 description 1
- 210000003741 urothelium Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating canine and feline urocystitis and a preparation method thereof. The traditional Chinese medicine composition for treating canine and feline urocystitis is prepared from the following raw materials: lysimachia chiristinae hance, pyrrosia lingua, spora lygodii, lindera aggregata, cimicifugae foetidae, radix bupleuri, yam rhizome, lophatherum gracile and talcum. In the formula of the traditional Chinese medicine composition, the lysimachia chiristinae hance, pyrrosia lingua and spora lygodii are taken as main drugs; based on the main drugs, the radix bupleuri is used so that the effects of soothing the liver, dispeling melancholy and regulating the flow of vital energy and removing obstruction toit can be achieved, the nourished qi can be circulated smooth and stagnation of the circulation of vital energy can be prevented; the cimicifugae foetidae is added, so that the effect of promoting middle qi can be achieved and the effect of tonifying middle-jiao and qi can be strengthened; the lophatherum gracile is added to remove heat to cool blood, discharge heart fire and induce diuresis, thereby helping to eliminate dampness-hear in lower jiao; the talcum, yam rhizome and lindera aggregata are used for achieving the effects of eliminating the dampness and turbidity, and promoting the circulation of qi and tonifying orifices, thereby achieving the purpose of strengthening the body resistance to eliminate pathogenic factors; the traditional Chinese medicine composition is free from toxic and side effects and obvious in curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, especially relate to Chinese medicine composition of a kind for the treatment of dog cat cystitis and preparation method thereof.
Background technology
Cystitis refers to the inflammation of mucous membrane of urinary bladder and submucous layer.Cat is more more common than dog clinically.Commonly hemorrhagic cystitis and Catarrhal cystitis.Clinical signs urodynamic, frequent micturition.During examination of urinary sediment, common urothelium, pyocyte and a large amount of erythrocyte and uric acid salt crystalline solid etc.Common crystalline solid has ammoniomagnesium phosphate and ammonium urate, secondly also has some carbonate, silicate and oxalates etc.
Cystitis mainly due to cause pathogeny imcrobe infection, serious long-pending urine, vesical calculus and close on organ inflammation spread and traumatic stimulation etc. causes.
Dog cat suffers from that this clinical symptoms cat spirit is after being ill depressed, and visual mucosa is pale, moving difficulty, slack anus and opening a business, and body temperature only has 36 DEG C ~ more than 41 DEG C.Minority body temperature 39 DEG C, great majority are 39.5 DEG C ~ 40 DEG C, breathe and pulse quickening.Afterbody and postabdomen are stained with the feces of Fructus Lycopersici esculenti sample, urine kermesinus or redness, and the bad smell having one special, have also with vomiting, there is the phenomenon of dehydration.
Pipemidic acid is generally adopted to treat for dog cat cystitis at present, but DeGrain.
Summary of the invention
The problem to be solved in the present invention is to provide a kind of Chinese medicine composition of safe and efficient, treatment dog cat cystitis that compatibility is reasonable, evident in efficacy.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
Treat a Chinese medicine composition for dog cat cystitis, it is characterized in that: it contains the raw material of Chinese medicine of following weight parts:
Preferably, the weight portion of its each raw material is:
The Chinese medicine composition that the present invention treats dog cat cystitis can be prepared into containing or not contain the various conventional extract oral medicine dosage form of pharmaceutic adjuvant.Described preparation can be water decoction.
Another object of the present invention is to provide a kind of preparation method treating the Chinese medicine composition of dog cat cystitis: step one: take each raw medicinal material respectively by described proportioning, after mixing, join be raw material of Chinese medicine 8-10 times weight portion water in, soak 1 hour, rear slow fire boiling 0.5 hour, filter, obtain medicinal residues and filtrate;
Step 2: the medicinal residues getting gained in step one, join be medicinal residues 8-10 times weight portion water in, soak 1 hour, rear slow fire boiling 0.5 hour, filter, abandon or adopt medicinal residues, by filtrate and step one filtrate merging, obtain water decoction.
The advantage that the present invention has and good effect are:
The present invention adopts Chinese medicine formula, is principal agent with Herba Lysimachiae, Folium Pyrrosiae, Spora Lygodii, mix Radix Bupleuri can soothing the liver, resolving depression, regulate the flow of vital energy, what make tonification is so incensed that with unimpeded, in case the stagnation of QI; Be aided with Rhizoma Cimicifugae can promote in gas have and strengthen the effect of invigorating the spleen and replenishing QI, Rhizoma Cimicifugae also can directly act on smooth muscle of bladder, and its contractility short is strengthened, and is the good medicine for the treatment of bladder; Add that Herba Lophatheri clearing away heat and cooling blood, eliminating heart-fire, diuresis are to help removing damp-heat in lower-JIAO; Be intended to secrete effect that is turbid, the sharp key of circulation of qi promoting with its dampness removing with Talcum, BIXUAN, the Radix Linderae, reach the object of strengthening vital QI to eliminate pathogenic factors, this formula has no side effect, and evident in efficacy.And the preparation technology that the present invention relates to has simply, processing ease, advantage easy to use, to be applicable to expanding production.
Detailed description of the invention
In embodiment, various raw material of Chinese medicine used all can be bought from market.
Embodiment 1
1, prescription composition
Herba Lysimachiae 15g, Folium Pyrrosiae 15g, Spora Lygodii 15g, Radix Linderae 15g, Rhizoma Cimicifugae 15g, Radix Bupleuri 15g, BIXUAN 15g, Herba Lophatheri 10g, Talcum 10g.
2, preparation method
Step one: each raw medicinal material taking prescription proportioning, after mixing, adds 1200ml water, soaks 1 hour, rear slow fire boiling 0.5 hour, filters, obtains medicinal residues and filtrate;
Step 2: the medicinal residues getting gained in step one, join be medicinal residues 8 times of weight portions water in, soak 1 hour, rear slow fire boiling 0.5 hour, filter, abandon or adopt medicinal residues, by filtrate and step one filtrate merging, obtain water decoction.
Usage and dosage: every day potion, every day early, late each 5ml, gavage after temperature.
Embodiment 2
1, prescription composition
Herba Lysimachiae 13g, Folium Pyrrosiae 13g, Spora Lygodii 15g, Radix Linderae 15g, Rhizoma Cimicifugae 15g, Radix Bupleuri 14g, BIXUAN 13g, Herba Lophatheri 10g, Talcum 12g.
2, preparation method
Step one: each raw medicinal material taking prescription proportioning, after mixing, adds 1200ml water, soaks 1 hour, rear slow fire boiling 0.5 hour, filters, obtains medicinal residues and filtrate;
Step 2: the medicinal residues getting gained in step one, join be medicinal residues 8 times of weight portions water in, soak 1 hour, rear slow fire boiling 0.5 hour, filter, abandon or adopt medicinal residues, by filtrate and step one filtrate merging, obtain water decoction.
Usage and dosage: every day potion, every day early, late each 5ml, gavage after temperature.
Embodiment 3
1, prescription composition
Herba Lysimachiae 15g, Folium Pyrrosiae 14g, Spora Lygodii 15g, Radix Linderae 13g, Rhizoma Cimicifugae 13g, Radix Bupleuri 13g, BIXUAN 13g, Herba Lophatheri 10g, Talcum 13g.
2, preparation method
Step one: each raw medicinal material taking prescription proportioning, after mixing, adds 1000ml water, soaks 1 hour, rear slow fire boiling 0.5 hour, filters, obtains medicinal residues and filtrate;
Step 2: the medicinal residues getting gained in step one, join be medicinal residues 8 times of weight portions water in, soak 1 hour, rear slow fire boiling 0.5 hour, filter, abandon or adopt medicinal residues, by filtrate and step one filtrate merging, obtain water decoction.
Usage and dosage: every day potion, every day early, late each 5ml, gavage after temperature.
Experimental example 1
Sick dog, cat 16 example, spirit is depressed, and visual mucosa is pale, moving difficulty, slack anus and opening a business, and body temperature only has 36 DEG C ~ more than 41 DEG C.Minority body temperature 39 DEG C, great majority are 39.5 DEG C ~ 40 DEG C, breathe and pulse quickening.Afterbody and postabdomen are stained with the feces of Fructus Lycopersici esculenti sample, urine kermesinus or redness, and the bad smell having one special, have also with vomiting, there is the existing picture of dehydration.Ill domestic animal Chang Duoci urinates on a small quantity or does posture of urinating, and during urine, pain is uneasy, even moans.Due to the swelling of neck of bladder mucosa or sensitivity time serious, pain is uneasy, causes urine retention because sphincter vesicae shrinks, external palpation bladder, ill domestic animal performance is responsive, and pain is uneasy, is because the bladder height that sphincter vesicae causes the swelling of spasmodic contraction or neck of bladder mucosa to cause fills.The muddy Catarrhal cystitis of urine color, containing a large amount of mucus and a small amount of protein in urine; Suppurative or cellulitis, containing pus in urine; Croupus cystitis, containing pseudomembrane in urine; Hemorrhagic cystitis, containing blood in urine; All containing leukocyte in various cystitis urine, Urothelial Cell, erythrocyte and ammonium phosphate crystallization.Seemingly, but the course of disease is slightly long for chronic cystitis symptom and Acute Phase, and symptom is slight, and often without performance of urinating, palpation wall of urinary bladder thickens, insensitive.By embodiment 1 treatment by Chinese herbs, within 5 days, cure.
Model case:
Case 1: dog, male, 4 years old, the cystitis that vesical calculus causes, x-ray examination had obvious calculus, long-term hematuria, and daily ration, based on commodity dog grain, is treated by embodiment 2, within 5 days, cures.
Case 2: cat, male, 2 years old, fear stranger, long-pending urine is serious, and bladder height fills, and during May Day, in family, guest is more, and 1-3 day has no urinates, so morbidity.Urinate color during urethral catheterization normal, be hematuria in the future.Treat by embodiment 3, within 5 days, cure.
Case 3: cat, male, 6 years old, daily ration was based on commodity cat grain, and urethral orifice place blocks has grains of sand calculus, filling of bladder, and also seeing during urethral catheterization has grains of sand calculus, hematuria.Treat by embodiment 3, within 5 days, cure.
Above embodiments of the invention have been described in detail, but described content being only preferred embodiment of the present invention, can not being considered to for limiting practical range of the present invention.All equalizations done according to the present patent application scope change and improve, and all should still belong within patent covering scope of the present invention.
Claims (6)
1. treat a Chinese medicine composition for dog cat cystitis, it is characterized in that: be made up of the raw material of Chinese medicine of following weight parts:
2. Chinese medicine composition according to claim 1, is characterized in that: the weight portion of its each raw material is:
3. Chinese medicine composition according to claim 1 and 2, is characterized in that: it is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. Chinese medicine composition according to claim 3, is characterized in that: described preparation can be water decoction.
5. prepare a method for Chinese medicine composition as claimed in claim 4, it is characterized in that:
Step one: take each raw medicinal material respectively by proportioning described in claim 1 or 2, after mixing, join be raw material of Chinese medicine 8-10 times weight portion water in, soak 1 hour, rear slow fire boiling 0.5 hour, filter, obtain medicinal residues and filtrate;
Step 2: the medicinal residues getting gained in step one, joining is that medicinal residues 8-10 doubly weighs in the water of part, soaks 1 hour, rear slow fire boiling 0.5 hour, filters, abandon or adopt medicinal residues, filtrate in filtrate and step one merged, obtain water decoction.
6. the application of the Chinese medicine composition described in any one of claim 1-4 in the medicine of preparation treatment dog cat cystitis.
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Effective date of registration: 20180420 Address after: 300384 Taihua Road 38, Xin Kou Town, Xiqing District, Tianjin (Xin Kou Town) Patentee after: Tianjin Jiaruixing Technology Development Co., Ltd. Address before: 251200, 6, Dezhou, Shandong City, Yucheng Province Patentee before: Liu Deying |
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Effective date of registration: 20191217 Address after: No.6 factory building, No.38, Taihua Road, Xinkou Town, Xiqing District, Tianjin 300000 Patentee after: Tianjin Xize Bioengineering Co., Ltd Address before: 300384 No.38, Taihua Road, Xinkou Town, Xiqing District, Tianjin (Xinkou town) Patentee before: Tianjin Jiaruixing Technology Development Co., Ltd. |
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Effective date of registration: 20220121 Address after: 430073 No. b274-20, second floor, building B1, Guanggu biological city, No. 666, Gaoxin Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan Yanxin Biotechnology Co.,Ltd. Patentee after: Jiang Ziying Address before: 300000 No.6 factory building, No.38, Taihua Road, Xinkou Town, Xiqing District, Tianjin Patentee before: Tianjin Xize Bioengineering Co.,Ltd. |
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