CN105434915A - Pharmaceutical composition for treating urolithiasis for dogs and cats and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating urolithiasis for dogs and cats and preparation method of pharmaceutical composition Download PDFInfo
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Abstract
The invention discloses pharmaceutical composition for treating urolithiasis for dogs and cats and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises components in parts by weight as follows: 20-40 parts of christina loosestrife, 10-30 parts of Lygodium japonicum, 10-30 parts of pyrrosia leaves, 10-20 parts of Plantago asiatica, 5-15 parts of chicken's gizzard-skin, 10-20 parts of lalang grass rhizomes, 10-20 parts of amur cork-trees, 6-10 parts of dried tangerine peel, 15-25 parts of common knotgrass herbs, 10-20 parts of lilac pink herbs, 12-20 parts of Wolfiporia extensa, 10-20 parts of medicinal cyathula roots and 1-3 parts of allopurinol. The composition can be prepared in forms of oral liquids, tablets or capsules and can be prepared with a processing method generally known by technicians in the field, that is, the traditional Chinese medicine raw materials are ground, pharmaceutical excipients are added, dissolved and uniformly mixed, and the pharmaceutical composition is obtained. The pharmaceutical composition has the characteristics that the effect is taken quickly, the curative effect is accurate and toxic and side effects are avoided.
Description
Technical field
The invention belongs to house pet veterinary drug technical field, be specifically related to a kind ofly be used for the treatment of pharmaceutical composition of dog cat urinary stone and preparation method thereof.
Background technology
Dog urinary stone disease is referred to as urinary calculus, refer to that the salts substances of dissolved state in urine is under the effect of some factor, separate out into inorganic or organic saline crystallization, and with the foreign body in urine for core forms the coherent structure of mineral (as volume crystallization, calculus or JISHI etc.), stimulate urinary tract mucosa, cause inflammation, hemorrhage diseases of urinary system of even blocking, it is the calculous general name in each position of urinary system, belong to " husky pouring " Chinese veterinarian, " stranguria caused by urinary stone ", categories such as " stranguria with blood ", it is the clinical common disease of house pet, fall ill in person in middle and old age small-sized dog colony especially more.Urinary stone can be deposited on each position of urinary tract, and from renal pelvis, ureter, bladder until urethra, and size, quantity are not etc.; What have adheres on mucosa, and what have is free state.The mechanical stimulus that calculus is harmful to for a long time to urinary system, can cause the inflammatory reaction of kidney, ureter, bladder or urethra; If calculus move with urine and block urinary tract time, can cause animals urine discharge difficulty; When urinary tract total blockage, there is urine retention, can uremia be caused time serious, or cause rupture of bladder, peritonitis etc., jeopardize the life of infected animal.The formation of urinary stone is not the process that mineral salt is assembled simply, piled up, but under many factors comprehensive function, with the product of generalized metabolic disorder of urinary organs pathological state.Main and diet, drinking-water, endocrine function, the running function of the metabolic condition of body mineral etc. and urinary system organ, particularly kidney etc. are because have close relationship.Chinese veterinarian thinks, the basic pathogenesis of urinary calculus damp and hotly accumulates bet, turning into fire and then burning YIN for a long time, decocts urine, forms sandstone, injury of blood collaterals by heat, hinders in urinary tract.
For less or medium sized urinary stone, veterinary clinic adopts drug administration to promote the conservative treatments such as calculus discharge, anti-inflammation hemostasia, supporting treatment usually.Conservative treatment is little to body injury, and urethrotomy can be avoided to cause the postoperative complications such as urethral fistula.Clinical conventional fossil, calculus medicine are based on Chinese medicine, and research shows, the calculus of 1.0cm of discharge total effective rate Chinese medicine is less than to(for) diameter is 73% ~ 98%, has good therapeutic effect to this kind of urinary calculus.Because suffering from dog long-term taking Chinese medicine decoction, serious resentment can be produced, the Chinese patent medicine of capsule, pill, tablets and other formulations can be fed.Allopurinol and metabolite oxypurinol thereof, by suppressing the activity of xanthine oxidase, make uricopoiesis reduce, and the uric acid content in blood and in urine is reduced to the level of below dissolubility, thus prevents the deposition of urate calculus.Absorb rapidly after oral allopurinol, 2/3 is oxipurinol at liver through the metabolism of xanthine oxidase synthase, and the latter is through renal excretion.Half-life is 2-3 hour, also very effective when kidney merit goes down.Over nearly 20 years, allopurinol is the important method of prevention calculus, now confirm again that calcium oxalate calculus formers often occurs hyperuricuria, therefore calcium oxalate calculus formers is particularly with hyperuricuria, can take allopurinol and urate excretion is reduced, and also can reduce calcium calculus recurrence.
The present invention is Chinese and western drugs compositions, Chinese medical discrimination in conjunction with doctor trained in Western medicine differential diagnosis of diseases, based on Chinese medicine, being aided with a small amount of Western medicine, is the good special product for the treatment of dog cat urinary stone effect, clearing away heat-damp and promoting diuresis, treating stranguria fossil, diuresis, promote that calculus is discharged, prevent recurrence of hepatolithiasis, three to surrounding rapid healing.
Summary of the invention
The object of the present invention is to provide a kind of more effective, side effect is little, free of contamination, has synergistic pharmaceutical composition; Another object of the present invention is to provide the preparation method of this veterinary drug and the application in treatment dog cat urinary stone thereof.
The present invention realizes especially by following technical scheme:
Be used for the treatment of a pharmaceutical composition for dog cat urinary stone, comprise by weight: Herba Lysimachiae 20 ~ 40 parts, Spora Lygodii 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 30 parts, Herba Plantaginis 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 5 ~ 15 parts, Rhizoma Imperatae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Pericarpium Citri Reticulatae 6 ~ 10 Fen, Herba Polygoni Avicularis 15 ~ 25, Herba Dianthi 10 ~ 20 parts, 12 ~ 20 parts, Poria, Radix Cyathulae 10 ~ 20 parts, allopurinol 1-3 part.
Preferably, be used for the treatment of a pharmaceutical composition for dog cat urinary stone, comprise by weight: Herba Lysimachiae 30 parts, Spora Lygodii 20 parts, Folium Pyrrosiae 20 parts, Herba Plantaginis 15 parts, Endothelium Corneum Gigeriae Galli 10 parts, Rhizoma Imperatae 15 parts, Cortex Phellodendri 15 parts, Pericarpium Citri Reticulatae 8 Fen, Herba Polygoni Avicularis 20 parts, Herba Dianthi 15 parts, 16 parts, Poria, Radix Cyathulae 15 parts, allopurinol 2 parts.
The medical mechanism of pharmaceutical composition of the present invention is: Herba Lysimachiae heat-clearing and toxic substances removing, and fossil is treating stranguria, dampness removing jaundice eliminating; Spora Lygodii clearing away damp-heat, treating stranguria pain relieving; Folium Pyrrosiae clearing heat and freeing strangury, cooling blood for hemostasis; Herba Plantaginis clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Endothelium Corneum Gigeriae Galli strengthening the spleen to promote digestion, fossil is treating stranguria; Rhizoma Imperatae cooling blood for hemostasis, heat-clearing and toxic substances removing; Cortex Phellodendri clearing away damp-heat, pathogenic fire purging poison; Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Herba Polygoni Avicularis relieving stranguria by diuresis, killing parasites for relieving itching; Herba Dianthi clearing away heat and promoting diuresis, promoting the circulation of blood blood stasis dispelling; Poria eliminating dampness and diuresis, spleen invigorating invigorating middle warmer; Radix Cyathulae blood circulation promoting and blood stasis dispelling, inducing diuresis for treating stranguria syndrome, invigorating the liver and kidney.All medicines share, and play fossil altogether treating stranguria, the merit of promoting urination and stopping pain; Allopurinol and metabolite thereof, can suppress xanthine oxidase, uric acid synthesized and reduces, and then reduce uric acid concentration in blood, reduces the calmness of urate at kidney.
The invention provides described pharmaceutical composition to apply in the medicine of preparation treatment dog cat Urolithiasis.
Pharmaceutical composition of the present invention can be processed into any additive acceptable dosage form, be more preferably wherein oral liquid, tablet or capsule, its preparation can well known to a person skilled in the art prepared by processing method by common, pulverize by raw material of Chinese medicine, add pharmaceutic adjuvant, dissolve, mix homogeneously, namely obtains the present composition.
The present composition can used through dissolving or direct spice before use by user.
Present invention also offers a kind of preparation method being used for the treatment of dog cat urinary stone oral liquid, specifically comprise the following steps:
1) take by weight: Herba Lysimachiae 20 ~ 40 parts, Spora Lygodii 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 30 parts, Herba Plantaginis 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 5 ~ 15 parts, Rhizoma Imperatae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Pericarpium Citri Reticulatae 6 ~ 10 Fen, Herba Polygoni Avicularis 15 ~ 25, Herba Dianthi 10 ~ 20 parts, 12 ~ 20 parts, Poria, Radix Cyathulae 10 ~ 20 parts, allopurinol 1-3 part;
2) Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae are added its gross weight 5-10 water doubly and first soak 1-2 hour, decoct again, boil and boil rear slow fire 30min, leach decocting liquid, decoct twice altogether, merging filtrate, concentrates to obtain Chinese herbs;
3) the decocting liquid of gained is added the alcoholic solution of Chinese crude drug gross mass 2-4 concentration 60-80% doubly, reflux 3-5 hour, extract, filter acquisition first extracting solution; Filter the alcoholic solution that the medicinal residues obtained add the 1-4 concentration 60-80% doubly of medicinal residues quality again, reflux 2-5 hour, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol, gets supernatant with the centrifugal 20min of 2000r/min for subsequent use after solution cooling;
4) get the appropriate distilled water of allopurinol to dissolve, add in gained supernatant and both obtained.
Preferably, a kind of preparation method being used for the treatment of dog cat urinary stone oral liquid, specifically comprises the following steps:
1) take by weight: Herba Lysimachiae 30 parts, Spora Lygodii 20 parts, Folium Pyrrosiae 20 parts, Herba Plantaginis 15 parts, Endothelium Corneum Gigeriae Galli 10 parts, Rhizoma Imperatae 15 parts, Cortex Phellodendri 15 parts, Pericarpium Citri Reticulatae 8 Fen, Herba Polygoni Avicularis 20 parts, Herba Dianthi 15 parts, 16 parts, Poria, Radix Cyathulae 15 parts, allopurinol 2 parts;
2) Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae are added its gross weight 5-10 water doubly and first soak 1-2 hour, decoct again, boil and boil rear slow fire 30min, leach decocting liquid, decoct twice altogether, merging filtrate, concentrates to obtain Chinese herbs;
3) the decocting liquid of gained is added the alcoholic solution of Chinese crude drug gross mass 2-4 concentration 60-80% doubly, reflux 3-5 hour, extract, filter acquisition first extracting solution; Filter the alcoholic solution that the medicinal residues obtained add the 1-4 concentration 60-80% doubly of medicinal residues quality again, reflux 2-5 hour, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol, gets supernatant with the centrifugal 20min of 2000r/min for subsequent use after solution cooling;
4) get the appropriate distilled water of allopurinol to dissolve, add in gained supernatant and both obtained.
Pharmaceutical composition of the present invention according to weight portion as proportioning, can increase according to corresponding ratio when producing or reduce, as large-scale production can by kilogram or in units of ton, small-scale production also can be in grams, weight can increase or reduce, but the raw medicinal herbs weight proportion constant rate between each composition.
Beneficial effect of the present invention is: Herba Lysimachiae joins Spora Lygodii, Folium Pyrrosiae, Endothelium Corneum Gigeriae Galli make its fossil treating stranguria, and promoting urination and stopping pain effect is strengthened; Poria compatibility Pericarpium Citri Reticulatae gets the merit of its spleen invigorating strength, strengthens transporting effect that body wets to water; Herba Polygoni Avicularis, Herba Dianthi compatibility Rhizoma Imperatae, Herba Plantaginis get the function of its heat-clearing and toxic substances removing, cooling blood for hemostasis, improve the hematuria card marquis caused by calculus; Cortex Phellodendri compatibility Radix Cyathulae gets its conducting blood to flow downwards, removing summer-heat damp-heat in the urinary bladder, and has nourishing characteristic to Liver and kidney, removes waist caused by calculus across pain, urinates puckery pain; Take allopurinol and can reduce uric acid concentration in blood, reduce urate in the calmness of kidney, also can reduce and prevent recurrence of hepatolithiasis.The present invention has instant effect, and curative effect is certain, feature without any side effects, and this medicine makes tablet or capsule, more adapts to the clinical application characteristic of house pet.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
One, embodiment part
Embodiment 1
Treat a Chinese and western medicinal composition for dog cat Urolithiasis, comprise Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae and allopurinol, concrete preparation method is as follows:
(1) Herba Lysimachiae 30 parts is got; Spora Lygodii 20 parts; Folium Pyrrosiae 20 parts; Herba Plantaginis 15 parts; Endothelium Corneum Gigeriae Galli 10 parts; Rhizoma Imperatae 15 parts; Cortex Phellodendri 15 parts; Pericarpium Citri Reticulatae 8 parts; Herba Polygoni Avicularis 20 parts; Herba Dianthi 15 parts; 16 parts, Poria; Radix Cyathulae 15 parts is raw material;
(2) water described Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae being added its gross weight 10 times first soaks 2 hours, then decocts, slow fire 30min after boiling.Leach decocting liquid, decoct twice altogether, merging filtrate, the Chinese herbs of concentrated 1g/ml.
(3) adding relative to the determining alcohol of mixture quality 3 times by the decocting liquid of gained is the ethanol of 80%, reflux 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of 3 times of described medicinal residues quality again, reflux 4 hours, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol.Supernatant is got with the centrifugal 20min of 2000r/min after solution cooling.
(4) get allopurinol 2 parts by above-mentioned weight portion, dissolve with appropriate distilled water, add in above-mentioned supernatant; Add pharmaceutic adjuvant again, dissolve, mix homogeneously, makes corresponding preparations.
(5) preparation method of the Chinese and western medicinal composition of above-mentioned treatment dog cat urinary stone, the dosage form of the Chinese and western medicinal composition that described step is made is oral liquid.
Embodiment 2
Treat a Chinese and western medicinal composition for dog cat Urolithiasis, comprise Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae and allopurinol, concrete preparation method is as follows:
(1) Herba Lysimachiae 20 parts is got; Spora Lygodii 10 parts; Folium Pyrrosiae 30 parts; Herba Plantaginis 10 parts; Endothelium Corneum Gigeriae Galli 15 parts; Rhizoma Imperatae 20 parts; Cortex Phellodendri 20 parts; Pericarpium Citri Reticulatae 10 parts; Herba Polygoni Avicularis 15 parts; Herba Dianthi 10 parts; 20 parts, Poria; Radix Cyathulae 20 parts is raw material;
(2) water described Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae being added its gross weight 10 times first soaks 2 hours, then decocts, slow fire 30min after boiling.Leach decocting liquid, decoct twice altogether, merging filtrate, the Chinese herbs of concentrated 1g/ml.
(3) adding relative to the determining alcohol of mixture quality 2 times by the decocting liquid of gained is the ethanol of 80%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of 1 times of described medicinal residues quality again, reflux 4 hours, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol.Supernatant is got with the centrifugal 20min of 2000r/min after solution cooling.
(4) get allopurinol 3 parts by above-mentioned weight portion, dissolve with appropriate distilled water, add in above-mentioned supernatant; Add pharmaceutic adjuvant again, dissolve, mix homogeneously, makes corresponding preparations.
(5) preparation method of the Chinese and western medicinal composition of above-mentioned treatment dog cat urinary stone, the dosage form of the Chinese and western medicinal composition that described step is made is oral liquid.
Embodiment 3
Treat a Chinese and western medicinal composition for dog cat Urolithiasis, comprise Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae and allopurinol, concrete preparation method is as follows:
(1) Herba Lysimachiae 40 parts is got; Spora Lygodii 30 parts; Folium Pyrrosiae 10 parts; Herba Plantaginis 20 parts; Endothelium Corneum Gigeriae Galli 5 parts; Rhizoma Imperatae 10 parts; Cortex Phellodendri 10 parts; Pericarpium Citri Reticulatae 6 parts; Herba Polygoni Avicularis 25 parts; Herba Dianthi 20 parts; 12 parts, Poria; Radix Cyathulae 10 parts is raw material;
(2) water described Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae being added its gross weight 5 times first soaks 2 hours, then decocts, slow fire 30min after boiling.Leach decocting liquid, decoct twice altogether, merging filtrate, the Chinese herbs of concentrated 1g/ml.
(3) adding relative to the determining alcohol of mixture quality 4 times by the decocting liquid of gained is the ethanol of 80%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of 4 times of described medicinal residues quality again, reflux 4 hours, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol.Supernatant is got with the centrifugal 20min of 2000r/min after solution cooling.
(4) get allopurinol 1 part by above-mentioned weight portion, dissolve with appropriate distilled water, add in above-mentioned supernatant; Add pharmaceutic adjuvant again, dissolve, mix homogeneously, makes corresponding preparations.
(5) preparation method of the Chinese and western medicinal composition of above-mentioned treatment dog cat urinary stone, the dosage form of the Chinese and western medicinal composition that described step is made is oral liquid.
Two, Application Example
Embodiment 4
For verifying the therapeutical effect of pharmaceutical composition of the present invention further, the clinical trial that inventors performed pet dog is investigated:
1) experiment material
Animal: suffer from calculus pet dog 20 clinically.
For reagent thing: make oral liquid.Get Herba Lysimachiae 30 parts; Spora Lygodii 20 parts; Folium Pyrrosiae 20 parts; Herba Plantaginis 15 parts; Endothelium Corneum Gigeriae Galli 10 parts; Rhizoma Imperatae 15 parts; Cortex Phellodendri 15 parts; Pericarpium Citri Reticulatae 8 parts; Herba Polygoni Avicularis 20 parts; Herba Dianthi 15 parts; 16 parts, Poria; Radix Cyathulae 15 parts is raw material; The water adding its gross weight 10 times first soaks 2 hours, then decocts, slow fire 30min after boiling.Leach decocting liquid, decoct twice altogether, merging filtrate, the Chinese herbs of concentrated 1g/ml.Adding relative to the determining alcohol of mixture quality 3 times by the decocting liquid of gained is the ethanol of 80%, reflux 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 80% that the medicinal residues that filtration obtains add relative to the determining alcohol of 3 times of described medicinal residues quality again, reflux 4 hours, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol.Supernatant is got with the centrifugal 20min of 2000r/min after solution cooling.Get allopurinol 2 parts, dissolve with appropriate distilled water, add in above-mentioned supernatant, dissolve, mix homogeneously, makes oral liquid.
Control drug: Shilintong Granule.
2) method and result
Suffer from calculus pet dog symptom: sick dog spirit is depressed, and poor appetite, becomes thin gradually, be reluctant to move, the symptoms such as urodynamic, hematuria, urgent micturition, frequent micturition, dysuria, bladder are full of, abdominal circumference Peng Long; The symptoms such as stomachache appears in indivedual several cases, the back of a bow.Abdominal touch inspection can feel that the comparatively hard or intravesical of kidney quality has rubble sample granule to suspect primary disease; Can be made a definite diagnosis by shadowgraph inspection, B-mode ultrasonography.
Therapeutic Method: get and suffer from calculus pet dog 20, be divided into 2 groups at random, test group of the present invention and matched group.Every day 2 times, successive administration 1 month, observes calculus and discharges situation and disease improvement situation.
Test group: oral 20mL/kg body weight, 2 times/day 1 month is a course for the treatment of.
Matched group: oral 5g/kg body weight, 3 times/day 1 month is a course for the treatment of.
Curative effect determinate standard:
Recovery from illness: calculus is discharged completely, urinate normal, abdominal touch is normal;
Effective: urodynamic and difficult symptom obviously alleviate, and without hematuria, calculus is discharged gradually;
Effective: urodynamic and difficult symptom alleviate to some extent, urinate normal;
Invalid: calculus is not discharged, dysuria, hematuria, urgent micturition, frequent micturition, dysuria, bladder are full of, abdominal circumference Peng Long, stomachache, and the symptoms such as the back of a bow still exist.
Therapeutic effect statistics is specifically in table 1.
Table 1 pet dog calculi therapy result
| Group | Number of animals | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Invention group | 10 | 5 | 3 | 1 | 1 | 90％ |
| Positive drug | 10 | 3 | 2 | 2 | 3 | 70％ |
Above result of the test shows, can obviously treat pet dog urinary stone for of the present invention group, more effective than control drug group.
Claims (5)
1. one kind is used for the treatment of the pharmaceutical composition of dog cat urinary stone, it is characterized in that, comprise by weight: Herba Lysimachiae 20 ~ 40 parts, Spora Lygodii 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 30 parts, Herba Plantaginis 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 5 ~ 15 parts, Rhizoma Imperatae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Pericarpium Citri Reticulatae 6 ~ 10 Fen, Herba Polygoni Avicularis 15 ~ 25, Herba Dianthi 10 ~ 20 parts, 12 ~ 20 parts, Poria, Radix Cyathulae 10 ~ 20 parts, allopurinol 1-3 part.
2. a kind of pharmaceutical composition being used for the treatment of dog cat urinary stone according to claim 1, it is characterized in that, comprise by weight: Herba Lysimachiae 30 parts, Spora Lygodii 20 parts, Folium Pyrrosiae 20 parts, Herba Plantaginis 15 parts, Endothelium Corneum Gigeriae Galli 10 parts, Rhizoma Imperatae 15 parts, Cortex Phellodendri 15 parts, Pericarpium Citri Reticulatae 8 Fen, Herba Polygoni Avicularis 20 parts, Herba Dianthi 15 parts, 16 parts, Poria, Radix Cyathulae 15 parts, allopurinol 2 parts.
3. pharmaceutical composition according to claim 1 and 2 is applied in the medicine of preparation treatment dog cat Urolithiasis.
4. application according to claim 3, is characterized in that, described pharmaceutical composition makes oral liquid, tablet or capsule.
5. be used for the treatment of a preparation method for dog cat urinary stone oral liquid, it is characterized in that, comprise the following steps:
1) take by weight: Herba Lysimachiae 20 ~ 40 parts, Spora Lygodii 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 30 parts, Herba Plantaginis 10 ~ 20 parts, Endothelium Corneum Gigeriae Galli 5 ~ 15 parts, Rhizoma Imperatae 10 ~ 20 parts, Cortex Phellodendri 10 ~ 20 parts, Pericarpium Citri Reticulatae 6 ~ 10 Fen, Herba Polygoni Avicularis 15 ~ 25, Herba Dianthi 10 ~ 20 parts, 12 ~ 20 parts, Poria, Radix Cyathulae 10 ~ 20 parts, allopurinol 1-3 part;
2) Herba Lysimachiae, Spora Lygodii, Folium Pyrrosiae, Herba Plantaginis, Endothelium Corneum Gigeriae Galli, Rhizoma Imperatae, Cortex Phellodendri, Pericarpium Citri Reticulatae, Herba Polygoni Avicularis, Herba Dianthi, Poria, Radix Cyathulae are added its gross weight 5-10 water doubly and first soak 1-2 hour, decoct again, boil and boil rear slow fire 30min, leach decocting liquid, decoct twice altogether, merging filtrate, concentrates to obtain Chinese herbs;
3) the decocting liquid of gained is added the alcoholic solution of Chinese crude drug gross mass 2-4 concentration 60-80% doubly, reflux 3-5 hour, extract, filter acquisition first extracting solution; Filter the alcoholic solution that the medicinal residues obtained add the 1-4 concentration 60-80% doubly of medicinal residues quality again, reflux 2-5 hour, extracts, and filters acquisition second extracting solution; Merge twice filtrate, concentrating under reduced pressure removing ethanol, gets supernatant with the centrifugal 20min of 2000r/min for subsequent use after solution cooling;
4) get the appropriate distilled water of allopurinol to dissolve, add in gained supernatant and both obtained.
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| CN201510835325.6A CN105434915A (en) | 2015-11-25 | 2015-11-25 | Pharmaceutical composition for treating urolithiasis for dogs and cats and preparation method of pharmaceutical composition |
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| CN201510835325.6A CN105434915A (en) | 2015-11-25 | 2015-11-25 | Pharmaceutical composition for treating urolithiasis for dogs and cats and preparation method of pharmaceutical composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106615872A (en) * | 2016-11-30 | 2017-05-10 | 钟梅 | Cat food for preventing urinary tract diseases |
| CN107375350A (en) * | 2017-08-23 | 2017-11-24 | 赵庆春 | Clear stone Chinese medicine composition and preparation method thereof |
| CN117159655A (en) * | 2023-10-12 | 2023-12-05 | 华南农业大学 | Cat soup capable of promoting urination and removing urinary calculus and preparation method of cat soup |
-
2015
- 2015-11-25 CN CN201510835325.6A patent/CN105434915A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106615872A (en) * | 2016-11-30 | 2017-05-10 | 钟梅 | Cat food for preventing urinary tract diseases |
| CN107375350A (en) * | 2017-08-23 | 2017-11-24 | 赵庆春 | Clear stone Chinese medicine composition and preparation method thereof |
| CN117159655A (en) * | 2023-10-12 | 2023-12-05 | 华南农业大学 | Cat soup capable of promoting urination and removing urinary calculus and preparation method of cat soup |
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