CN1327874C - Chinese medicine formulation for treating chronic prostatitis and its preparing method - Google Patents
Chinese medicine formulation for treating chronic prostatitis and its preparing method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine preparation for treating chronic prostatitis and a preparation method thereof. The Chinese medicine preparation is mainly prepared from polygonum capitatum and hemlock parsley; the polygonum capitatum and the hemlock parsley are added into ethanol and extracted in a refluxing mode, and after the materials are filtered, filter liquid is obtained; the filter liquid is recycled into the ethanol, and the mixture is condensed into thick paste of certain relative density; the thick paste is dried and crumbled into fine powder, and then active components in the Chinese medicine preparation of the present invention are prepared; the obtained active components are prepared into the needed preparation in a conventional method. The Chinese medicine preparation has special curative effect on treating urinary system infections, and can effectively treat chronic prostatitis.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of chronic prostatitis and preparation method thereof, belong to technical field of Chinese medicine.
Background technology: chronic prostatitis belongs to categories such as " stranguria ", " nebulousurine ", " lumbago ", " smart turbid " of the traditional Chinese medical science, is common clinical, frequently-occurring disease and difficult treatment, is more common in male person between twenty and fifty.Its sickness rate is observed discovery from pathologic angle and is accounted for about 30～50% of postmortem; Epidemiology among the crowd is not seen the complete information statistics as yet, but most authors report accounts for Urologic Surgery Clinic adult male patient's about 35%.Chronic prostatitis is to serve as the clinical symptom grouping of main performance with lower urinary tract symptom drawn game portion pain, often form jointly by the disease due to several different reasons with unique forms, so be called again the chronic prostatitis syndrome (Chronic Prostatitis Syndromes, CPS).The pathological characteristic of chronic prostatitis is: 1. many focuses property; 2. inflammation is wrapped up; 3. glandular tube blocks, inadequate drainage; 4. gland leaf fibreization.The western medical treatment primary disease generally adopts antibiotic to carry out at present; But effect is dissatisfied, and reason is: the bacterial prostatitis that the clear and definite cause of disease is arranged that 1. occupies the minority because of the barrier action of prostate acinus epithelium, makes antibacterials fully not penetrate in glandular tube glandular cell and the secretions and goes; The nonbacterial prostatitis that is in the great majority then uses antibiotic invalid; 2. above-mentioned pathological anatomy characteristics make medicine be difficult to arrive sick institute, or can't form effective blood drug level again after arriving sick institute, and the medicine of low concentration very easily induces pathogenic microorganism to produce drug resistance; 3. whole body or local immunity power are unusual.
Though primary disease generally can not cause the grievous injury of important organ and threat to life, because the special condition of illness of this disease, it is usually painful unusual to suffer from the patient, has not only influenced patient's quality of life, and may have influence on happy family life and even social labour productivity.Increasing in recent years data shows that antibiotic resistant rate rises gradually, and antibacterial in case per urethram or blood follow and enter prostate, then make treatment become rather thorny.And for nonbacterial prostatitis, it is unnecessary and powerless that antibiotic then seems.Someone tries out alpha-blocking agent or non-steroidal drug anti symptom treatment, and its curative effect is also pessimistic.Abroad also occurred in recent years treating primary disease (as Prostat), obtained certain clinical efficacy, yet along with the improving constantly of living standard, people are the uphold nature therapy more, and the quality and quantity of health care is had higher requirement with plant amedica.Therefore, the medicine of seeking new high-efficiency low-toxicity is very necessary.In recent years, the report of relevant Chinese medicine chronic prostatitis increases year by year, and the developmental research of this disease being carried out new Chinese medicine is also more, but most of product function is single, therapeutic effect is not desirable especially yet.By secular clinical practice, we have carried out in depth inquiring into to the occurrence regularity of chronic prostatitis, think that damp invasion of lower energizer, qi and blood stagnation are its basic pathogenesis, have only to examine because of opinion and control, and could improve curative effect.
Summary of the invention: purpose of the present invention just provides a kind of Chinese medicine preparation for the treatment of chronic prostatitis and preparation method thereof.
The present invention utilizes the active characteristics of the good antimicrobial antiphlogistic of Herba Polygoni Capitati in conjunction with Chinese medical theory and distinguished veteran doctors of TCM clinical treatment experience for many years, the employing Herba Polygoni Capitati is a monarch drug, be equipped with Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae four flavor Chinese medicines composition experience sides, be used for the urine urgency-frequency due to damp invasion of lower energizer, the stagnation of QI-blood; dribbling urination is not well, urethra scorching hot or nebulousurine is arranged; Chronic prostatitiss such as perineum, lower abdomen, the bloated pain of lumbosacral region bob are seen above-mentioned patient.
The present invention constitutes like this: the Chinese medicine preparation of treatment chronic prostatitis: calculate according to components by weight percent, it mainly is to be prepared from by Herba Polygoni Capitati 10-50, Rhizoma Chuanxiong 5-20; Specifically: it is prepared into by Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g.The preparation method of the Chinese medicine preparation of described treatment chronic prostatitis: weighting raw materials Herba Polygoni Capitati, Rhizoma Chuanxiong, Herba Polygoni Capitati, the Rhizoma Chuanxiong of described weight proportion are added the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste of certain relative density; Thick paste is dry and be ground into fine powder, just be prepared into the active component of Chinese medicine preparation of the present invention; The active component that obtains is prepared into the preparation that needs according to conventional method.The Chinese medicine preparation of this treatment chronic prostatitis: calculate according to components by weight percent, wherein also have: Rhizoma Dioscoreae Hypoglaucae 5-25, Radix Angelicae Dahuricae 2-15g.That is to say: the Chinese medicine preparation of this treatment chronic prostatitis is prepared into by Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g and Radix Angelicae Dahuricae 10g.The preparation method of the Chinese medicine preparation of this treatment chronic prostatitis: weighting raw materials Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae and the Radix Angelicae Dahuricae, Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae and the Radix Angelicae Dahuricae of described weight proportion are added the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste of certain relative density; Thick paste is dry and be ground into fine powder, just be prepared into the active component of Chinese medicine preparation of the present invention; The active component that obtains is prepared into oral formulations or ejection preparation according to conventional method.
Furtherly: the Chinese medicine preparation of treatment chronic prostatitis: calculate according to components by weight percent, wherein also have Radix Achyranthis Bidentatae 5-25.So, this pharmaceutical preparation by: Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g are prepared from.
Its preparation method: weighting raw materials Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae and Radix Achyranthis Bidentatae, Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae and the Radix Achyranthis Bidentatae of described weight proportion are added the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste of certain relative density; Thick paste is dry and be ground into fine powder, just be prepared into the active component of Chinese medicine preparation of the present invention; The active component that obtains is prepared into oral formulations according to conventional method, comprises: granular preparation (containing effervescent granule), hard capsule preparation, soft capsule preparation, tablet formulation (containing effervescent tablet, controlled release tablet, slow releasing tablet, oral cavity disintegration tablet, chewable tablet etc.), dropping pill formulation, oral liquid, syrup preparation.More specific preparation method is: take by weighing Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g, add the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate, with filtrate recycling ethanol and be concentrated into the thick paste of certain relative density, dry, be ground into fine powder, add right amount of auxiliary materials, mixing is granulated, make granule 1000g, promptly get granular preparation.
Required various conventional adjuvant in the time of among the present invention the active component of the Chinese medicine preparation that obtains can being added the preparation different dosage form is prepared into any common dosage forms as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine.
The present invention is to serve as that the basis proposes the treatment urinary system infection is had the Miao Ethnomedicine Herba Polygoni Capitati of unique curative effect and the clear granule of single preparations of ephedrine pyretic stranguria thereof, select Herba Polygoni Capitati among the present invention for use, Rhizoma Chuanxiong Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae makes up, thereby make each efficacy of drugs produce synergism these drug regimens and can effectively treat chronic prostatitis, Herba Polygoni Capitati mildly bitter flavor wherein, hot, cool in nature, return kidney, urinary bladder channel is the dry herb or the aerial parts of polygonaceae plant Herba Polygoni Capitati, has clearing away heat-damp and promoting diuresis, the detoxifcation pain relieving, promoting blood circulation to remove blood stasis, the merit of inducing diuresis for treating stranguria syndrome is used for dysentery, nephritis, cystitis, lithangiuria, pelvic inflammatory disease, prostatitis, rheumatalgia, traumatic injury, skin infection eczema etc.This medicine is highly suitable for the card of " pyretic stranguria " that the traditional Chinese medical science says, is monarch drug so this side reuses Herba Polygoni Capitati.The Rhizoma Chuanxiong acrid in the mouth, warm in nature, return liver, gallbladder, pericardium, all warps of three warmers." medicine justice " carries: " Rhizoma Chuanxiong is gone into liver, gallbladder, three warmers three warps." " belonging to pure sun " " can rise and can fall." the Materia Medica of Decoction meaning: " Rhizoma Chuanxiong is started with, meridian of Foot-JUE YIN." Li Shizhen (1518-1593 A.D.) then is called " gas medicine in the blood ", kindly controls the stagnation of QI and blood disease, occupies first of the activating blood and removing stasis drug, has blood-activating and qi-promoting, the effect of stasis-dispelling and pain-killing.Rhizoma Chuanxiong and Herba Polygoni Capitati are compatible, have both had clearing away heat-damp and promoting diuresis, and the merit of inducing diuresis for treating stranguria syndrome strengthens its unobstructed QI and blood again, and the effect of promoting blood circulation and stopping pain is so be ministerial drug.The Rhizoma Dioscoreae Hypoglaucae bitter in the mouth, property is flat.Return kidney, stomach warp.Compendium of Material Medica is carried: “ Rhizoma Dioscoreae Septemlobae and is controlled nebulousurine, pains in the penis, bad skin ulcer of anal fistula." " medical center is usurped and wanted the property of medicine " point out, Rhizoma Dioscoreae Septemlobae can " clear small intestine fire be changed bladder water for slow liver, hard kidney." function of " Chinese materia medica " Wei Rhizoma Dioscoreae Septemlobae is eliminating damp-heat, separating clear and excreting turbid, dispeiling pathogenic wind and removing dampness.Be mainly used in cards such as nebulousurine, stranguria marked by chyluria, leukorrhagia, rheumatic arthralgia.Be that treatment part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels turbid damp is retarded by silt, the key medicine of turbid urine.For example, bixie fenqing drink plus-minus commonly used is a monarch drug Yi Rhizoma Dioscoreae Septemlobae in the stranguria, and the treatment damp invasion of lower energizer is pure and impure mixed mutually, and disease sees that turbid urine is short red, diseases such as the puckery pain of urethra scorching hot, and curative effect is rather good.Then main compatible with Herba Polygoni Capitati among the we, to strengthen clearing away damp-heat from lower-JIAO, branch Qinghua is turbid, the effect of inducing diuresis for treating stranguria syndrome.Radix Angelicae Dahuricae acrid in the mouth, warm in nature, return lung, large intestine, stomach warp.The function understand things pain-stopping, the wind dehumidifying of loosing, detumescence and apocenosis.Be used for cards such as painful diseases and women's leukorrhagia, ulcer sores clinically more.As " herbal classic " day: " main woman's whitish metrorrhagia, blood closes swelling of the vulva." " property of medicine opinion " also cloud: " and the Radix Angelicae Dahuricae can be controlled the twinge of trusted subordinate's blood stasis, exorcising, and main woman's metrorrhagia and vomiting are treated married woman's lumbago with blood stasis, can lose pus." in the stranguria this medicine normal with the same usefulness of Rhizoma Chuanxiong, with the enhancing promoting flow of QI and blood, the effect of inducing menstruation to relieve menalgia (as beam balls all).In addition, the Radix Angelicae Dahuricae also is the common drug of surgery of Chinese medicine, as the golden yellow cream in surgery classics side, dash and loose in all use the Radix Angelicae Dahuricae, function promoting blood circulation and detumescence, promoting the circulation of QI to relieve pain.Generally be used for carbuncle from the beginning of, congestion and swelling pain, overflow swollen no first-class disease.So Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae are adjuvant altogether in the side, to help the power of monarch, ministerial drug thing.Radix Achyranthis Bidentatae sour in the mouth, hardship, property is flat, returns liver, kidney channel." China book on Chinese herbal medicine " is called Radix Achyranthis Bidentatae, to show the difference with Radix Cyathulae." Bencao Jingshu " pointed out: " the rich gas of Radix Achyranthis Bidentatae is thin, walks and can mend, and it is descending that property is apt to, so go into liver, kidney." " book on Chinese herbal medicine converge with speech " also carry: " go into Three Yin Channels of Foot, it is descending very prompt to draw all medicines." its function has nourishing the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, conducting blood to flow downwards, diuresis inducing function.Cure mainly soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, pyretic stranguria, stranguria with blood, cards such as carbuncle malignant boil.Point out that as Compendium of Material Medica Radix Achyranthis Bidentatae " is controlled the chronic malaria cold and heat, five types of stranguria hematuria, pains in the penis, dysentery, carbuncle malignant boil." etc.So, Radix Achyranthis Bidentatae normal with compatibilities such as Rhizoma Chuanxiong, the Cortex Eucommiae, parasitism, with enhancing nourishing the liver and kidney, strong muscles and bones, the effect of promoting blood circulation and stopping pain.Many again and Cortex Phellodendri, Rhizoma Dioscoreae Septemlobae, the same usefulness of Herba Plantaginis are gone into the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels with eliminating damp-heat, inducing diuresis for treating stranguria syndrome.It is descending that Radix Achyranthis Bidentatae can draw all medicines in addition, can also be as the tying-in medicine, so do messenger drug with it.Radix Achyranthis Bidentatae and above four Chinese medicine thing are compatible, and existing liver and kidney tonifying effect has strengthened full side's inducing diuresis for treating stranguria syndrome again, the function of blood circulation promoting and blood stasis dispelling.
Taking a broad view of full side, is guidance with the Chinese medical theory, the cool and usefulness of medicine temperature, and treating both the principal and the secondary aspects of a disease at the same time, reinforcement and elimination in combination is to attack heresy.Its reasonable recipe, medication is precise and appropriate, and has local characteristic, and all medicines share, and gather clearing away heat-damp and promoting diuresis altogether, inducing diuresis for treating stranguria syndrome, the merit of promoting blood circulation and stopping pain, and have the effect of nourishing the liver and kidney concurrently.
Pharmacological room of Sichuan Industrial Institute of Antibiotics experimentation shows: Herba Polygoni Capitati, tangible resisting pathogenic microbes effect is arranged, has a broad antifungal spectrum, comprise multiple gram positive bacteria, escherichia coli, gonococcus, Bacillus proteus, Ureaplasma urealyticum, sand holes chlamydia or the like, and these all may be to cause prostatitic pathogen.The Herba Polygoni Capitati extract powder is tested the diuresis of anesthesia rabbit and normal rat: confirm that this medicine 17.4g crude drug in whole/kg dosage has tangible diuresis to the anesthesia rabbit; 8.7g crude drug in whole/kg dosage has tangible diuresis to normal rat.Simultaneously, the Herba Polygoni Capitati extract powder has good antiinflammatory action to inflammatory models such as rat paw edema, mice ear and rat granulomas, and dose-effect relationship is preferably arranged.In addition, Herba Polygoni Capitati is used for writhing method and the radiant heat stimulus method is made the mice pain model, confirms to have certain analgesic activity.Continuous 20 days of Herba Polygoni Capitati extract powder 4g/Kg irritates stomach prostatitis rat, and the prostatitis of rat is had obvious therapeutic action.Pharmacological actions such as above-mentioned antibiotic, antiinflammatory, diuresis, analgesia again at disadvantageous pathological factor, provide experimental basis for Herba Polygoni Capitati is selected as monarch drug both at pathogen.Rhizoma Chuanxiong contains ligustrazine, and the effect of regulating blood coagulation, reducing whole blood viscosity is arranged; Isolated rat or guinea pig heart had the effect of significant increase coronary flow; External rabbit and platelet aggregation by ADP, collagen and thrombin induction there are remarkable inhibitory action, and can make the rapid depolymerization of accumulative platelet; Can improve the effect of rabbit red blood cell deformation and reduction whole blood viscosity; In addition, ligustrazine can obviously increase the rabbit kidney blood flow, and remarkable diuresis is arranged.So modern study confirms that Rhizoma Chuanxiong truly has tangible blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain effect.Rhizoma Dioscoreae Hypoglaucae, its rhizome contain powder back of the body Saponin A, and Barrelierin etc. have tangible antifungic action, and blood fat reducing are arranged and reduce the effect of atherosclerosis of aorta incidence rate.The Radix Angelicae Dahuricae, its root contains imperatorin, different imperatorin and various trace elements etc.Have analgesic, analgesia and antiinflammatory action, Radix Angelicae Dahuricae decoct is irritated stomach, and the experiment of mice hot plate method can make the threshold of pain obviously improve, and xylol induced mice ear inflammation also has obvious inhibitory action.Experimentation confirms that isoimperatorin has spasmolysis to the rabbit ileum.The experiment in vitro result, the Radix Angelicae Dahuricae has in various degree inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus and some gram-positive bacterium etc.Radix Achyranthis Bidentatae contains triterpenoid saponin and multiple polysaccharide etc., has tangible antiinflammatory, analgesic activity; The Radix Achyranthis Bidentatae decoct is irritated stomach, and high low shear rate whole blood viscosity, the erythrocyte aggregation index of normal rat all had remarkable reduction effect, and prothrombin time and blood plasma recalcification time are prolonged, but the mechanism of the partial interpretation Radix Achyranthis Bidentatae effect of invigorating blood circulation.In addition, experiment shows that Radix Achyranthis Bidentatae all has immunological enhancement to the normal or low animal of immunologic function.More than these The pharmacological results provide experimental basis for we's reasonability, effectiveness.
This product prescription is on pharmacological research and the empirical basis of clinical practice, follows the Chinese medical theory and the principles of formulating prescriptions, designs at the damp and hot syndrome of blood stasis of chronic prostatitis.This product is a method of treatment with clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain, and the applicant has finished quality standard, safety and pharmacodynamic experiment again after finishing prescription demonstration, fixed dosage form, optimization technology, confirms that this side is safe, effective preparation of treatment chronic prostatitis.
The pharmacy part:
Prescription and technical study:
Determining on the basis of consulting domestic and international Chinese medicine modern study document of the extraction process route of this technology, according to this prescription function cure mainly and write out a prescription in the physicochemical property of the contained effective ingredient of each medicine, formulated with water extract-alcohol precipitation and two kinds of preparation technologies of alcohol extraction.And with the extract powder of the present invention of these two kinds of prepared for be subjected to sample this, from the quality of two kinds of extraction process extracts of antimicrobial antiphlogistic angle preparation more of the present invention, result of study shows: alcohol extraction process extract antimicrobial antiphlogistic is better respectively.Therefore determined that preparation technology of the present invention is alcohol extraction process.And it is preferred that alcohol extraction process is carried out orthogonal test, presses L
9(3
4) the orthogonal test calendar carries out repeated trials three times, is index with extractum yield and quercetin content, to concentration of alcohol, ethanol consumption, extraction time, four factors of extraction time are optimized investigation, optimize optimum extraction process.Carried out the selection of method of granulating at last, the determining of adjuvant type selecting and consumption, the determining of medicated powder water content, granulation pressure Study on Forming such as determine, determined preparation prescription and method for making.Simple for process, workable through pilot scale scale-up proof, adapt to big requirement of producing.
Quality standard research:
According to relevant requirements under Chinese Pharmacopoeia (2000 editions an one) the granule item and " medicine registration management way " regulation, and carry out the lot of documents retrieval, formulated clinical trial of the present invention on this basis with drug standard (draft) and draft explanation.Adopt thin layer chromatography that Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae among the present invention are carried out qualitative identification, be that qualitative index is differentiated Rhizoma Chuanxiong wherein with the Rhizoma Chuanxiong control medicinal material, with the diosgenin is that qualitative index is differentiated Rhizoma Dioscoreae Hypoglaucae, with Radix Angelicae Dahuricae control medicinal material is that qualitative index is differentiated the Radix Angelicae Dahuricae, is that qualitative index is differentiated Radix Achyranthis Bidentatae with the oleanolic acid.The result shows three batch samples (lot number is respectively 040801,40802,040803), all with reference substance or control medicinal material chromatograph relevant position on show the same color speckle, negative noiseless, the income text." Herba Polygoni Capitati " assay item that reference " Guizhou Province's Chinese crude drug, national quality of medicinal material standard " is recorded, with reference to high performance liquid chromatography (" appendix VID of Chinese pharmacopoeia version in 2000), assay to Quercetin among the present invention is studied, assay through methodology system thinking and three batch samples (lot number is respectively 040801,040802,040803), Quercetin and other component separating are good among the present invention, Quercetin is good in 0.0804～0.4823 μ g scope internal linear, average application of sample yield is 98.61%, RSD=1.13% (n=5).The result shows: the method is easy, quick, exclusive, sensitive, accurate.And regulation this product contains Quercetin for every bag and must not be less than 5.6mg.This particulate every index of regulation all meets " the pertinent regulations under an appendix IC of Chinese pharmacopoeia version in 2000 the granule item simultaneously.
The result shows: the stable easily row of this standard, and controllability is strong, and good reproducibility can be controlled quality of the present invention.
The preliminarily stabilised Journal of Sex Research:
Cold test:
According to " specification requirement of new Chinese medicine stability study " and regulation,,, under room temperature condition, investigate with the clinical trial drug packaging with three batch samples (lot number 040801,040802,040803).The investigation time is 3 months, and except that investigating this month once, later examination every month once.The examination project, by clinical trial drug quality draft standard, and, draft the examination project and be: character, discriminating, inspection (granularity, moisture, melting, content uniformity, microbial limit), assay in conjunction with " requirements of new Chinese medicine stability test " investigation project formulation to granule requirement.Detect with the detection method of clinical trial with drug quality draft standard regulation.The result of appraisal: three batch samples were at room temperature placed 3 months, and every detection index relatively there is no significant change with " 0 " moon, illustrates that this product quality is basicly stable.
Accelerated test research:
The investigation project is with reference to the quality standard (draft) of clinical trial of the present invention with medicine, and combination " requirement of new Chinese medicine stability test " has been carried out accelerated test research to the investigation project formulation that granule requires to the present invention.Three batch samples (lot number is respectively 040801,040802,040803) are carried out (40 ℃ ± 2 ℃, 75% ± 5%RH) of 3 months accelerated tests with clinical trial with drug packaging, by preparation appearance character (moisture absorption, softening), discriminating, inspection (granularity, moisture, melting, content uniformity, microbial limit), assay project are investigated, projects detect index and compare with " 0 " moon, there is no significant change, illustrate that this product quality is basicly stable, used packaging material do not have influence to medicine.
Result of study by above pharmacy part shows: technology of the present invention is rationally feasible, and is stable and controllable for quality.
Pharmacology, toxicity part:
Main pharmacodynamics research:
The antiinflammatory result of the test shows, compare with the solvent matched group, the high, medium and low dosage group of the present invention (20.0,10.0,5.0g crude drug/kg) can obviously suppress the ear swelling (p＜0.01) that dimethylbenzene causes, inhibitory rate of intumesce is respectively 80.6%, 77.4% and 67.7%.The high, medium and low dosage group of the present invention (14.4,7.2,3.6g/kg) all is formed with inhibitory action to rat granuloma is swollen, and suppression ratio is respectively 28.8%, 15.7% and 21.5%.
The analgesic test is the result show, compares with the solvent matched group, and the mouse writhing number of times that high dose group of the present invention (20.0g/kg) Dichlorodiphenyl Acetate causes can more obviously suppress (p＜0.05).With compare before the administration, high dose group of the present invention has inhibitory action to the pain that irradiated with thermal radiation Mus tail causes, the threshold of pain improves 69.1%.
The carbon clearance result of the test shows, the high, medium and low dosage group of the present invention (20.0,10.0,5.0g/kg) all can obviously increase and engulf speed K value, engulfs the half-life obviously to prolong, and can promote the phagocytic activity of mice reticuloendothelial system.
Carrageenin causes rat acute prostatitis result of the test and shows, compare with model group, height of the present invention, middle dosage (14.4,7.2g/kg) significantly reduce the leukocyte count in the rat prostate liquid, lecithin density obviously increases, remarkable statistical significance (p＜0.01, p＜0.05) is arranged.Histopathology result shows that the prostata tissue morphology of normal control group does not have remarkable change, and the visible prostata tissue hyperemia of model group, edema, cell infiltration is obvious.Compare with model group, low dose group of the present invention (3.6g/kg) does not have obvious improvement to the morphology of rat prostate, visible obviously prostatic edema, cell infiltration, but body of gland destruction is lighter.Compare with model group, height of the present invention, middle dosage group (14.4,7.2g/kg) have clear improvement to the morphology of rat prostate, wherein, both all obviously alleviate interstitial edema and body of gland and destroy (p＜0.01), high dose more obviously alleviates cell infiltration (p＜0.05), and middle dosage obviously alleviates cell infiltration (p＜0.01).Check conclusion: compare with model group, the middle and high dosage group of the present invention makes moderate progress both no significant differences to the morphology of rat prostate inflammation.
Carrageenin causes rat chronic prostatitis result of the test and shows, with model group relatively, high dose group rat prostate coefficient of the present invention obviously reduces, the rat prostate hypertrophy has inhibitory action (p＜0.05) due to the on Carrageenan.Histopathology result shows, compares with model group, and the tectology of low, the middle dosage group of the present invention does not have obvious improvement.High dose group of the present invention obviously alleviates fibroblast proliferation and cell infiltration (p＜0.05), and high dose group tectology of the present invention has clear improvement.
The stasis syndrome rat test is the result show, rat is after modeling, and the basic, normal, high whole blood viscosity of cutting is compared obvious increase with packed cell volume with the normal control group.With model group relatively, height of the present invention, middle dosage group (14.4,7.2g/kg) can significantly reduce the whole blood viscosity (p＜0.01) under the high, medium and low shear rate of stasis syndrome rat; High dose group of the present invention can obviously reduce packed cell volume (p＜0.05).
Water load anesthesia rabbit intra-ureteral cannula diuretic test is the result show, height of the present invention, middle dosage group (7.6,3.8g/kg) have obvious diuresis (p＜0.05, p＜0.01) to the anesthesia rabbit, and onset time is than positive drug hydrochlorothiazide and QIANLIEHUICHU WAN.
In sum, the present invention has analgesia, antiinflammatory, raising immunity, diuresis, can improve simultaneously clinical indices and histopathologic change that rat acute due to the carrageenin, chronic prostatitis cause, can also reduce the whole blood viscosity of stasis syndrome rat, have function of promoting blood circulation to disperse blood clots.
In-vitro antibacterial experimental result of the present invention shows: external antibacterial tests result to 221 strain clinical bacterias shows that the present invention has certain antibacterial activity to test strain; The minimum bactericidal concentration result of the test shows that the present invention is better to the bactericidal activity of each test strain; The change of inoculation bacterium amount has certain influence to antibacterial activity of the present invention, and when inoculum concentration increased, MIC also raise.The change of culture medium pH value is to not significantly influence of antibacterial activity of the present invention.
Studies on acute toxicity:
With maximum drug level, maximum administration volume 1.0ml/20g, 193g/kg
-1Behind gastric infusion or the lumbar injection, observed continuously 14, as a result mice none is only dead.Animals administer same day, the individual animal autonomic activities slightly reduces, and other shows no obvious abnormalities; All animal Non Apparent Abnormality situations are found after 1 day; Experimental session, do not find mice on the feed, aspects such as breathing, heart rate, chroma of hair unusual.Show that mouse gavaging or lumbar injection maximum tolerated dose of the present invention is 193g/kg
-1, 152 times (it is 76g crude drug/day/people for human dosage that clinical people intends consumption, by 60kg/ people) of intending consumption for clinical people.
Long term toxicity research:
(38.6g/kg, 19.3g/kg 9.7g/kg), are equivalent to (30 times, 15 times, 7.5 times) of human dosage to the high, medium and low dosage group of the present invention approximately, and non-toxic is 19.3g.kg
-115 times (human dosage is 76g/ day/people, by 60kg/ people) that are equivalent to human dosage approximately.Gastric infusion in 13 weeks of successive administration, is learned index in hematological indices, the blood biochemical of 13 weeks of administration and drug withdrawal 2 convalescent periods in week measurement rats, and is observed the general performance of rat in experimentation, record food consumption and body weight change.Get 20,10 rats respectively and carry out system and become celestial in finishing every group in 2 weeks of administration three months, convalescent periods, calculate organ index, and internal organs are carried out histopathology detect.The result shows, 13 weeks of gastric infusion of the present invention the activity situation of rat, body weight, food ration etc. do not had obviously to change; High dose group (38.6g.kg of the present invention
-1) (red blood cell count(RBC), content of hemoglobin, packed cell volume reduce the animal part hematological indices, and lymphocyte quantity increases), indivedual blood biochemistry index (blood urea nitrogen and uric acid increase) has to a certain degree and changes, 2 week of drug withdrawal the back These parameters all can recover; High dose group animal lungs and male rat testicular weight and matched group have alleviated 3.6% and 8% more respectively.In, the low dose group animal do not find the significantly toxic reaction relevant with drug effect.The pathological change relevant with medication of the present invention all do not found in histological examination, each dosage group.Under this experimental condition, continuous 13 weeks of gastric infusion of the present invention the non-toxic to rat be 19.3g.kg
-1, be equivalent to approximately 15 times (human dosage is 76g/ day/people, by 60kg/ people) of human dosage.
The specific embodiment:
Embodiments of the invention 1: take by weighing Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g, the ethanol that adds 10 times of amounts 60%, reflux, extract, 3 times, each 1.5 hours, merge 3 times extracting solution, filter filtrate, with filtrate recycling ethanol and to survey relative density when being concentrated into 60 ℃ be the thick paste of 1.25-1.30, with the thick paste drying under reduced pressure and be ground into fine powder, add aspartame 10g then, lactose is an amount of, magnesium stearate 3g, mixing, dry-pressing is granulated, make granule 1000g, promptly get granular preparation.This product boiled water is taken after mixing it with water, one time 1 bag, three times on the one.
Embodiments of the invention 2: take by weighing Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g, the ethanol that adds 8 times of amounts 60%, reflux, extract, 1 time, 1 hour, merge extractive liquid,, filter filtrate, survey relative density with filtrate recycling ethanol and when being concentrated into 60 ℃ and be 1.25 thick paste, dry, be ground into fine powder, add right amount of auxiliary materials, mixing, granulate, make granule 1000g, promptly get granular preparation.
Embodiments of the invention 3: take by weighing Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g, add the ethanol of 20 times of amounts 80%, reflux, extract, 5 times, each 5 hours, merge extractive liquid,, filter filtrate, survey relative density with filtrate recycling ethanol and when being concentrated into 60 ℃ and be 1.30 thick paste, dry, be ground into fine powder, add right amount of auxiliary materials, mixing is granulated, make granule 1000g, promptly get granular preparation.
Embodiments of the invention 4: take by weighing Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g, the ethanol that adds 8 times of amounts 60%, reflux, extract, 2 times, each 1 hour, merge 2 times extracting solution, filter filtrate, with filtrate recycling ethanol and to survey relative density when being concentrated into 60 ℃ be the thick paste of 1.25-1.30, with the thick paste drying under reduced pressure and be ground into fine powder, add an amount of Macrogol 4000, after heating is mixed thoroughly, splash in the another kind of not miscible liquid coolant dimethicone, drip and make ball, promptly get drop pill.This Macrogol 4000 can be used instead and be polyoxyethylene (40) monostearate; The dimethicone liquid coolant can change any one in liquid paraffin or the vegetable oil into.
Embodiments of the invention 5: weighting raw materials Herba Polygoni Capitati 10g, Rhizoma Chuanxiong 5g, Rhizoma Dioscoreae Hypoglaucae 5g, Radix Angelicae Dahuricae 2g and Radix Achyranthis Bidentatae 5g, the ethanol that adds 8 times of amounts 60%, reflux, extract, 2 times, each 1 hour, merge 2 times extracting solution, filter filtrate, with filtrate recycling ethanol and to survey relative density when being concentrated into 60 ℃ be the thick paste of 1.25-1.30, with the thick paste drying under reduced pressure and be ground into fine powder, directly incapsulate or to add 2% carboxymethylcellulose sodium solution an amount of, the moistening granulation of water, mixing, incapsulate, make 1000 of capsules, promptly get capsule preparations.2% carboxymethylcellulose sodium solution can be used instead and be ethanol.
Embodiments of the invention 6: weighting raw materials Herba Polygoni Capitati 50g, Rhizoma Chuanxiong 20g, Rhizoma Dioscoreae Hypoglaucae 25g, Radix Angelicae Dahuricae 15g and Radix Achyranthis Bidentatae 25g, the ethanol that adds 20 times of amounts 60%, reflux, extract, 4 times, each 4 hours, merge 4 times extracting solution, filter filtrate, with filtrate recycling ethanol and be concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃ of survey); With the thick paste drying under reduced pressure and be ground into fine powder, add 2% carboxymethylcellulose sodium solution, the moistening granulation of water, drying, tabletting is pressed into 1000, promptly gets tablet formulation.
Embodiments of the invention 7: weighting raw materials Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g and Radix Angelicae Dahuricae 10g, add 10 times of amount ethanol of 60%, reflux, extract, 3 times, each 1.5 hours, merge 3 times extracting solution, filter filtrate; Filtrate recycling ethanol is to an amount of, refining, to filter, it is an amount of that filtrate adds active carbon, boiled 15 minutes, filter, it is an amount of to add water for injection, stirs evenly, and the pH value of regulator solution is 7.0～7.4, to clear and bright, embedding was sterilized 30 minutes, and was promptly got injection for 100 ℃ with filtering with microporous membrane.
Embodiments of the invention 8: weighting raw materials Herba Polygoni Capitati 10g, Rhizoma Chuanxiong 5g, Rhizoma Dioscoreae Hypoglaucae 5g and Radix Angelicae Dahuricae 2g, add 8 times of amount ethanol of 30%, reflux, extract, 1 time, 1 hour, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste that relative density is 1.25 (60 ℃ of surveys); With the thick paste drying under reduced pressure and be ground into fine powder, add an amount of Macrogol 4000, after heating is mixed thoroughly, splash in the another kind of not miscible liquid coolant dimethicone, drip and make ball, promptly get drop pill.This Macrogol 4000 can be used instead and be that polyoxyethylene (40) monostearate, dimethicone liquid coolant can be used instead and be in liquid paraffin or the vegetable oil any one.
Embodiments of the invention 9: weighting raw materials Herba Polygoni Capitati 50g, Rhizoma Chuanxiong 20g, Rhizoma Dioscoreae Hypoglaucae 25g and Radix Angelicae Dahuricae 15g, add 20 times of amount ethanol of 80%, reflux, extract, 5 times, each 5 hours, merge 5 times extracting solution, filter filtrate; With filtrate recycling ethanol and be concentrated in right amount, it is an amount of to add antiseptic and simple syrup, regulates total amount to 1000ml, stirs evenly, filter, and fill, every 10ml, sterilization promptly gets oral liquid.Correctives simple syrup wherein also can be used instead and be Mel.
Embodiments of the invention 10: weighting raw materials Herba Polygoni Capitati 30g and Rhizoma Chuanxiong 12g, add 10 times and measure 60% ethanol, reflux, extract, 3 times, each 1.5 hours, merge 3 times extracting solution, filter; With filtrate recycling ethanol and be concentrated in right amount, it is an amount of to add antiseptic and simple syrup, makes total amount to 1000ml, stirs evenly, and filters, and promptly gets syrup preparation.
Embodiments of the invention 11: weighting raw materials Herba Polygoni Capitati 10g and Rhizoma Chuanxiong 5g, add 8 times of amount ethanol of 60%, reflux, extract, 1 time, 1 hour, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste that relative density is 1.25 (60 ℃ of surveys); With the thick paste drying under reduced pressure and be ground into fine powder, it is an amount of to add the diluent that PEG400 and Cera Flava form, and grinds well, standby; It is standby that other gets gelatin solution (100 parts in gelatin, 50 parts of glycerol, 120 parts in water); Under the condition of 23 ± 2 ℃ of room temperatures, relative humidity 40%, medicinal liquid and gelatin solution are pressed into ball, promptly get soft capsule preparation.PEG400 can use instead for vegetable oil (can be one or more the miscella in soybean oil, Oleum Arachidis hypogaeae semen, the Oleum Camelliae.)
Embodiments of the invention 12: weighting raw materials Herba Polygoni Capitati 50g and Rhizoma Chuanxiong 20g, add 20 times of amount ethanol of 80%, reflux, extract, 5 times, each 5 hours, merge 5 times extracting solution, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste that relative density is 1.30 (60 ℃ of surveys); With the thick paste drying under reduced pressure and be ground into fine powder, mixing adds aspartame 10g then, and lactose is an amount of, magnesium stearate 3g, and mixing is granulated, and makes granule 1000g, promptly gets granular preparation.Correctives aspartame wherein can change sucrose into, and lactose can be used instead and be dextrin.
Claims (10)
1, a kind of Chinese medicine preparation for the treatment of chronic prostatitis is characterized in that: calculate according to components by weight percent, it mainly is to be prepared from by Herba Polygoni Capitati 10-50, Rhizoma Chuanxiong 5-20.
2, according to the Chinese medicine preparation of the treatment chronic prostatitis of claim 1, it is characterized in that: it is prepared into by Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g.
3, treat the preparation method of the Chinese medicine preparation of chronic prostatitis as claimed in claim 1 or 2, it is characterized in that: weighting raw materials Herba Polygoni Capitati, Rhizoma Chuanxiong, Herba Polygoni Capitati, the Rhizoma Chuanxiong of described weight proportion are added the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste of certain relative density; Thick paste is dry and be ground into fine powder, just be prepared into the active component of this preparation; The active component that obtains is prepared into the preparation that needs according to conventional method.
4, according to the Chinese medicine preparation of the described treatment chronic prostatitis of claim 1, it is characterized in that: calculate according to components by weight percent, wherein also have: Rhizoma Dioscoreae Hypoglaucae 5-25, Radix Angelicae Dahuricae 2-15.
5, according to the Chinese medicine preparation of the described treatment chronic prostatitis of claim 4, it is characterized in that: it is prepared into by Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g and Radix Angelicae Dahuricae 10g.
6, according to the Chinese medicine preparation of the described treatment chronic prostatitis of claim 4, it is characterized in that: calculate according to components by weight percent, wherein also have Radix Achyranthis Bidentatae 5-25.
7, according to the Chinese medicine preparation of the described treatment chronic prostatitis of claim 6, it is characterized in that: it by: Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g are prepared from.
8, as the preparation method of the Chinese medicine preparation of treatment chronic prostatitis as described in the claim 5, it is characterized in that: weighting raw materials Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae and the Radix Angelicae Dahuricae, Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae and the Radix Angelicae Dahuricae of described weight proportion are added the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste of certain relative density; Thick paste is dry and be ground into fine powder, just be prepared into the active component of this preparation; The active component that obtains is prepared into oral formulations or ejection preparation according to conventional method.
9, as the preparation method of the Chinese medicine preparation of treatment chronic prostatitis as described in the claim 7, it is characterized in that: weighting raw materials Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae and Radix Achyranthis Bidentatae, Herba Polygoni Capitati, Rhizoma Chuanxiong, Rhizoma Dioscoreae Hypoglaucae, the Radix Angelicae Dahuricae and the Radix Achyranthis Bidentatae of described weight proportion are added the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate; With filtrate recycling ethanol and be concentrated into the thick paste of certain relative density; Thick paste is dry and be ground into fine powder, just be prepared into the active component of this preparation; The active component that obtains is prepared into granular preparation, hard capsule preparation, soft capsule preparation, tablet formulation, dropping pill formulation, oral liquid or syrup preparation according to conventional method.
10, according to the preparation method of the Chinese medicine preparation of the described treatment chronic prostatitis of claim 9, it is characterized in that: take by weighing Herba Polygoni Capitati 30g, Rhizoma Chuanxiong 12g, Rhizoma Dioscoreae Hypoglaucae 12g, Radix Angelicae Dahuricae 10g and Radix Achyranthis Bidentatae 12g, add the ethanol that 8-20 doubly measures 30-80%, reflux, extract, 1-5 time, each 1-5 hour, merge extractive liquid,, filter filtrate, with filtrate recycling ethanol and be concentrated into the thick paste of certain relative density, dry, be ground into fine powder, add right amount of auxiliary materials, mixing, granulate, make granule 1000g, promptly get granular preparation.
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| CN112071179B (en) * | 2020-09-27 | 2022-02-11 | 北京博医时代教育科技有限公司 | Method for manufacturing training model for medical transurethral resection |
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| CN1435218A (en) * | 2002-11-15 | 2003-08-13 | 贵州奇凯制药有限责任公司 | Medicine for treating stranguria |
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| CN1435218A (en) * | 2002-11-15 | 2003-08-13 | 贵州奇凯制药有限责任公司 | Medicine for treating stranguria |
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Address after: Guizhou province Guiyang city Wudang District High Road No. 23 Patentee after: Guizhou Warmen Pharmaceutical Co., Ltd. Address before: Torch Avenue, industrial zone, Guiyang hi tech Development Zone, Guizhou, China Patentee before: Guizhou Warmen Pharmaceutical Co., Ltd. |