CN103721131B - A kind of Chinese medicine suppository and its preparation method treating women's chronic pelvic inflammatory disease - Google Patents

Abstract

The present invention discloses a kind of Chinese medicine suppository treating women's chronic pelvic inflammatory disease, the weight part number of various raw material is: the red sage root 10��20 parts, Herba Andrographis 10��20 parts, Yunnan Caulis Spatholobi 10��20 parts, Motherwort Herb 10��20 parts, 10��20 parts, peach kernel, Herba Patriniae 10��20 parts, Stem of Sargentgloryvine 10��20 parts, the radix paeoniae rubrathe 10��20 parts, Flos Campsis 10��20 parts, Williams Elder Twig 10��20 parts, taraxacum 10��20 parts, the root of large-flowered skullcap 10��20 parts, the Fruit of Belveder 10��20 parts, indigo naturalis 10��20 parts, Fructus Cnidii 10��20 parts, White Mulberry Root-bark 10��20 parts, skunk bush 10��20 parts, raspberry 10��20 parts, the root of herbaceous peony 10��20 parts, rhizoma cyperi 10��20 parts, the root of Dahurain angelica 10��20 parts, kuh-seng 10��20 parts, Rhizome of Glabrous Greenbrier 10��20 parts. the present invention has effect of promoting blood circulation and removing blood stasis, eliminating damp-heat, through focus, and for the treatment of the common diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cysts, vaginitis, effect is remarkable. the present invention has dissolves fast, release advantage rapidly, reaches rapid recovery symptom object.

Description

A kind of Chinese medicine suppository and its preparation method treating women's chronic pelvic inflammatory disease

Technical field

The present invention relates to containing the medicinal preparation deriving from plant, animal or raw mineral materials, in particular to a kind of Chinese medicine suppository and its preparation method for the treatment of women's chronic pelvic inflammatory disease.

Background technology

Female pelvic inflammation refers to the inflammation of internal genitalia (comprising uterus, uterine tube, the other reticular tissue in palace and pelvic cavity peritonaeum), both can be confined to certain position of female body, it is possible to relate to whole internal genitalia. If when pathology is only confined to uterine tube and ovary, being commonly referred to appendagitis. Pathological development process according to female pelvic inflammation, clinical is divided into acute pelvic inflammatory disease and chronic pelvic inflammatory disease two kinds, in motherland's medical science, under this disease belongs to stomachache, invasion of the blood-chamber by heat, band, the category such as infertile.

Chronic pelvic inflammatory disease comprises chronic adnexitis and chronic pelvic inflammation of connective tissue. It is hardening that the former often shows as uterine tube wall thickening, and mucous layer has inflammatory exudation thing, and uterine tube sticks together, and pipe chamber is blocked, even ovary get involved simultaneously and with uterine tube break-through, form uterine tube ovarian cysts or abscess. The latter's Ze Yin acute inflammation fails thoroughly to cure and develop into chronic, owing to organizing hyperemia, oedema, proliferation of fibrous tissue, hardening then occurs again, its inflammation also may resemble the through pelvic cavity of external diffusion in sector, therefore uterus is often fixed, and this kind of chronic inflammatory diseases state of an illness is obstinate, not easily effects a radical cure.

Chronic pelvic inflammatory disease mainly shows as lower abdomen falling inflation pain, waist stock pain, sometimes uncomfortable with rectal tenesmus, increase the weight of after fatigue of being everlasting, sexual intercourse, when arranging just and before and after menstruation, in addition, it is also possible to frequent micturition, leucorrhea increasing, irregular menstruation, dysmenorrhoea and the symptom such as infertile. During gynaecological examination, if appendagitis, can be increase thick bar pallial siphuncle or sheet block in the one or both sides in uterus, and with tenderness; As formed hydrosalpinx or uterine tube tumour, then can touch cystic enclosed mass; If inflammation of pelvic connective tissue, both sides, uterus can increase thick in the form of sheets and have tenderness in various degree.

Chronic pelvic inflammatory disease is common gynecological disease, difficult treatment, has the feature of touching recurrence of not healing, be easy to, and is the big difficult problem of in domestic and international gyniatrics. It is thorough that chronic pelvic inflammatory disease mostly is acute pelvic inflammatory disease treatment, and patient meets flu, overwork etc. causes disease resistance low, and pathogeny bacterium is active again causes pelvic inflammation recurrence, also has part patient to there is no acute inflammation history, slowly sick because rising, caused by ignorance is treated. Its pathological change is inflammatory exudation in pelvic cavity, organ adhesion, local organization scar proliferation, and uterus maintains static. Pelvic congestion is hyper-menorrhea then, and ovarian function damages then menoxenia, and fallopian tube adhesion is then infertile, and hydrosalpinx is ovarian cysts then.

Motherland's medical science thinks that this disease is many by hollow through row born of the same parents in postpartum arteries and veins, invades uterus in affection of exogenous damp heat poison; Or spleen suffers from a deficiency of the kidney damage, retention of water-damp in the body is heat-transmission with the passing of time; Or overfeeding delicious food savoury, interior life is damp and hot, bet uterus; Or fire caused by depression of liver-QI, phlegm fire streamer uterus, causes pelvic cavity viscera inner membrance QI-blood circulation not smooth, and damp evil heat poison, phlegm fire hemostasis are tied mutually, suppuration, infringement pelvic tissue. Due to lose control or control by mistake, cause recurrent exerbation, delay do not heal, organ-tissue adhesion, hyperplasia and become lump in the abdomen enclosed mass. This disease actual situation is mingled with, the damp and hot phlegm stasis of blood is suffered from mutually each other, and spleen damage of suffering from a deficiency of the kidney is it, and damp and hot phlegm stasis blocking is stagnant is its mark.

Within the scope of China and the world, the sickness rate of women's chronic pelvic inflammatory disease is all in rising trend, and the grievous injury physical and mental health of numerous women, brings trouble not to the utmost to life, and treat this persistent ailment never effective method. The patient of chronic pelvic inflammatory disease mostly recurrent exerbation, touching difficulty more, affects quality of life. Though most patient seeks medical advice in many ways, but general all poor effect, cause anxiety, depression, and then further increase the weight of the state of an illness, seriously affect work and quality of life.

Summary of the invention

Technical problem to be solved by this invention is, chronic pelvic inflammatory disease, and appendagitis is common gynecological disease, and mostly being acute pelvic inflammatory disease, to fail appropriate thoroughly treatment or patient's physique poor, and caused by course of disease delay, this state of an illness is more obstinate. The medicine being used for the treatment of this disease at present has Western medicine, also has Chinese medicine. But mostly curative effect is not remarkable for these medicines, has been the effect of temporary transient mitigate the disease, and can not reach the object of thoroughly healing, can only maintain or alleviate the state of an illness, can not effect a radical cure. Therefore make many patient's delay treatments or obstinate recurrent exerbation, cause patient's menoxenia, cause sterile (Infertility). The present invention combines clinical experience for many years on the basis of traditional medicine, adopts modern processing method meticulously to develop. The present invention to each effective constituent scientific compatibility of raw material medicine, focus of going directly, and instant effect, side effect is little, biocidal property is strong preparation, can efficient solution except the misery of patient, reach the object of dispelling disease.

For solving the problems of the technologies described above, the present invention provides a kind of Chinese medicine preparation treating women's chronic pelvic inflammatory disease, in described Chinese medicine suppository, the weight part number of various raw material is: the red sage root 10��20 parts, Herba Andrographis 10��20 parts, Yunnan Caulis Spatholobi 10��20 parts, Motherwort Herb 10��20 parts, 10��20 parts, peach kernel, Herba Patriniae 10��20 parts, Stem of Sargentgloryvine 10��20 parts, the radix paeoniae rubrathe 10��20 parts, Flos Campsis 10��20 parts, Williams Elder Twig 10��20 parts, taraxacum 10��20 parts, the root of large-flowered skullcap 10��20 parts, the Fruit of Belveder 10��20 parts, indigo naturalis 10��20 parts, Fructus Cnidii 10��20 parts, White Mulberry Root-bark 10��20 parts, skunk bush 10��20 parts, raspberry 10��20 parts, the root of herbaceous peony 10��20 parts, rhizoma cyperi 10��20 parts, the root of Dahurain angelica 10��20 parts, kuh-seng 10��20 parts, Rhizome of Glabrous Greenbrier 10��20 parts.

The Chinese medicine suppository of described treatment women's chronic pelvic inflammatory disease, in Chinese medicine suppository described in it, the weight part number of various raw material can be: the red sage root 10��15 parts, Herba Andrographis 10��15 parts, Yunnan Caulis Spatholobi 10��15 parts, Motherwort Herb 10��15 parts, 10��15 parts, peach kernel, Herba Patriniae 10��15 parts, Stem of Sargentgloryvine 10��15 parts, the radix paeoniae rubrathe 10��15 parts, Flos Campsis 10��15 parts, Williams Elder Twig 10��15 parts, taraxacum 10��15 parts, the root of large-flowered skullcap 10��15 parts, the Fruit of Belveder 10��15 parts, indigo naturalis 10��20 parts, Fructus Cnidii 10��20 parts, White Mulberry Root-bark 10��20 parts, skunk bush 10��20 parts, raspberry 10��20 parts, the root of herbaceous peony 10��20 parts, rhizoma cyperi 10��20 parts, the root of Dahurain angelica 10��20 parts, kuh-seng 10��20 parts, Rhizome of Glabrous Greenbrier 10��20 parts.

The Chinese medicine suppository of described treatment women's chronic pelvic inflammatory disease, in Chinese medicine suppository described in it, the weight part number of various raw material can also be: the red sage root 10��20 parts, Herba Andrographis 10��20 parts, Yunnan Caulis Spatholobi 10��20 parts, Motherwort Herb 10��20 parts, 10��20 parts, peach kernel, Herba Patriniae 10��20 parts, Stem of Sargentgloryvine 10��20 parts, the radix paeoniae rubrathe 10��20 parts, Flos Campsis 10��20 parts, Williams Elder Twig 10��20 parts, taraxacum 10��20 parts, the root of large-flowered skullcap 10��20 parts, the Fruit of Belveder 10��20 parts, indigo naturalis 10��15 parts, Fructus Cnidii 10��15 parts, White Mulberry Root-bark 10��15 parts, skunk bush 10��15 parts, raspberry 10��15 parts, the root of herbaceous peony 10��15 parts, rhizoma cyperi 10��15 parts, the root of Dahurain angelica 10��15 parts, kuh-seng 10��15 parts, Rhizome of Glabrous Greenbrier 10��15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of Chinese medicine suppository treating women's chronic pelvic inflammatory disease, the preparation process of described suppository comprises: by described bulk drug except the root of Dahurain angelica and rhizoma cyperi, all the other add water soaking 30 minutes to 1 hour, heated and boiled 30��40 minutes, filtering, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 30��40 minutes, filters, and filtrate is for subsequent use; Filter residue adds water again, for the third time heated and boiled 30��40 minutes, filters; Three filtrates being combined, heating concentrates to paste, then the root of Dahurain angelica, rhizoma cyperi steam distillation is extracted, and obtains crystallisate, is mixed in ointment obtained above; Choosing matrix 50 DEG C��60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.

The preparation method of the Chinese medicine suppository of described treatment women's chronic pelvic inflammatory disease, the matrix used of suppository described in it is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, polyoxyethylene glycol, lanolin; Described matrix is heating and melting under temperature 50 DEG C��60 DEG C conditions, adds the medicine lotion that described preparation method obtains, and stirring in water bath is even, is mixed into sticky thick liquid, is poured in plastics calibration tube, the cotton bolt of insertion, and cooling and shaping makes bullet-shaped suppository; Described cotton bolt is the cotton bolt of afterbody with cotton thread.

For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of Chinese medicine suppository treating women's chronic pelvic inflammatory disease, and the preparation process of described suppository comprises further:

A. described bulk drug is put into except the root of Dahurain angelica and rhizoma cyperi pulverizer grinding and sieving,

B. the particulate matter being left after sieving is put into ethanol heating and refluxing extraction 2 times;

C. the dregs of a decoction after above-mentioned extraction using alcohol are got again, the heating and refluxing extraction that adds water 2 times;

D. rhizoma cyperi and the root of Dahurain angelica being distilled crystallization of vaporizing to obtain, add in above-mentioned two kinds of extracting solutions, matrix Mixer pot sets type, and ultraviolet is killed virus.

In described step a, it is possible to put into except the root of Dahurain angelica and rhizoma cyperi by described bulk drug after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 order sieves is reaching 30%, collects the raw material fine powder by 100 order sieves for subsequent use.

In described step b, it is possible to the particulate matter being left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1��2 hour, No. 2 extracting solutions are merged and leaves standstill;

In described step c, it is possible to the dregs of a decoction that above-mentioned extraction using alcohol is crossed are added 10 times amount water heating and refluxing extraction 2 times, each 1��2 hour, No. 2 extracting solutions are merged and leaves standstill.

In described steps d, it is possible to crystallization of rhizoma cyperi and root of Dahurain angelica distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solutions are merged, the filtrate of 1.37 when concentrating under reduced pressure relative density is 80 DEG C, reclaim ethanol, gained filtrate is adjusted proportion to 1.06, stir even after adding the fine powder and crystalline powder sieved, pour in matrix, 50 DEG C��60 DEG C heating and melting, cooling and shaping makes class warhead shape suppository, and the proportioning of described pulvis Chinese patent medicine and matrix is 1: 2��1: 4; Described cotton bolt is the cotton bolt of afterbody with cotton thread.

The present invention adopts stype and cotton bolt integrated technique, compensate for the deficiency of ordinary suppository, and ordinary suppository can not effectively be delivered to the depths of vagina. Due to the self-purification of vagina, when there being foreign matter to exist, increasing liquid secretion, be got rid of by medicine external within the short period of time, both reduce curative effect, extend again the course for the treatment of, increase expense pollutes again underwear underclothes. And the present invention overcomes this technical barrier, the suppository made can give full play to curative effect of medication, has security good, the advantage that feasibility is good, and focus of going directly, reaches the object that gets rid of illness.

The advantages such as compared with prior art, this technology has convenient drug administration, and medicament is easy to manufacture, with low cost. The present invention has effect promoting blood circulation and removing blood stasis, eliminating damp-heat, for the pelvic inflammatory disease that the stagnation of the circulation of vital energy is pented up, the diseases such as disease sees profuse leukorrhea, hypogastralgia, is applicable to the treatment of the common diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cysts, vaginitis simultaneously, and effect is remarkable. This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid recovery symptom and treatment.

Embodiment

Pelvic inflammatory disease, is equivalent in the disease categories such as " band is lower sick " in motherland's medical science, " menoxenia ", " dysmenorrhoea ", " abdominal mass ". After the pathogenic factor of this disease mostly is childbirth, miscarriage, gynecilogical operation or menstruation, blood sinus is open, and to some extent accidentally, toxic dampness and heat is taken advantage of a weak point, if excess of pathogen healthy tendency is also contained, then the state of an illness oncoming force is relatively violent, contains weakened body resistance if evil, then acute inflammation situation is very unobvious. Many controlling because of mistake is controlled by mistake and is transferred chronic phase to. Clinical the most common with chronic pelvic inflammatory disease person. Its interpretation of the cause, onset and process of an illness for wet turbid, damp and hot, that the evil poison of cold-dampness pents up the stasis of blood is stagnant at uterus, born of the same parents' arteries and veins so that channels and collaterals to close resistance obstructed, functional activity of QI being not smooth, coagulation of QI-blood and become. Thus acute phase heavy dose of clearing heat and detoxicating, the wet agent promoting blood circulation and removing blood stasis of profit. The chronic phase delays by acute phase, owing to the passing of time meridian stasis stagnant, so will with promoting blood circulation and removing blood stasis, it is main that heat-clearing, profit are wet, and drinks the product adding benefit gas, also to be differentiated wet turbid character, add invigorating spleen to remove dampness or medicine clearing heat and detoxicating, temperature sun dampness elimination flexibly, routine can not be stuck to. Therefore should tonifying speen and tonifying kidney dissipating bind soothing the liver, promoting blood circulation and removing blood stasis wet, clearing heat and detoxicating of eliminating the phlegm be basic therapy.

Chronic pelvic inflammatory disease is common gynecological disease, difficult treatment, has the feature of touching recurrence of not healing, be easy to, and is the big difficult problem of in domestic and international gyniatrics. It is thorough that chronic pelvic inflammatory disease mostly is acute pelvic inflammatory disease treatment, and patient meets flu, overwork etc. causes disease resistance low, and pathogeny bacterium is active again causes pelvic inflammation recurrence, also has part patient to there is no acute inflammation history, slowly sick because rising, caused by ignorance is treated. Its pathological change is inflammatory exudation in pelvic cavity, organ adhesion, local organization scar proliferation, and uterus maintains static. Pelvic congestion is hyper-menorrhea then, and ovarian function damages then menoxenia, and fallopian tube adhesion is then infertile, and hydrosalpinx is ovarian cysts then.

Motherland's medical science thinks that this disease is many by hollow through row born of the same parents in postpartum arteries and veins, invades uterus in affection of exogenous damp heat poison; Or spleen suffers from a deficiency of the kidney damage, retention of water-damp in the body is heat-transmission with the passing of time; Or overfeeding delicious food savoury, interior life is damp and hot, bet uterus; Or fire caused by depression of liver-QI, phlegm fire streamer uterus, causes pelvic cavity viscera inner membrance QI-blood circulation not smooth, and damp evil heat poison, phlegm fire hemostasis are tied mutually, suppuration, infringement pelvic tissue. Due to lose control or control by mistake, cause recurrent exerbation, delay do not heal, organ-tissue adhesion, hyperplasia and become lump in the abdomen enclosed mass. This disease actual situation is mingled with, the damp and hot phlegm stasis of blood is suffered from mutually each other, and spleen damage of suffering from a deficiency of the kidney is it, and damp and hot phlegm stasis blocking is stagnant is its mark.

The object of the present invention, the curative effect being exactly the medicine for pelvic inflammatory disease in gynaecopathia is all undesirable, takes effect slower, human body side effect is big, body of women harm is relatively big, and easy shortcoming repeatedly, the medicine that a kind of instant effect is produced in invention, side effect is little, biocidal property is strong, to release the misery of patient. The present invention inherits the medical science legacy of motherland, Traditional Chinese Medicine is developed, utilize Chinese herbal medicine resource advantage all over the mountains and plains, develop the Chinese medicine preparation of a kind of special efficacy, safety, convenience, inexpensive, pure natural, in order to treat the common gynecological diseases such as the various pelvic inflammatory disease of women, frequently-occurring disease, makes up Western medicine toxic side effect big, and body of women is endangered the defects such as dark. Preparation technology of the present invention is simple, and medicine material is cheap, good effect, can reach relatively good social effect and economic interests. The present invention has effect promoting blood circulation and removing blood stasis, eliminating damp-heat, for the pelvic inflammatory disease that the stagnation of the circulation of vital energy is pented up, the diseases such as disease sees profuse leukorrhea, hypogastralgia, is applicable to the treatment of the common diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cysts, vaginitis simultaneously, and effect is remarkable. This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid recovery symptom and treatment.

Flos Campsis selected by traditional Chinese medicine for oral administration of the present invention, sweet cool, clearing heat and promoting diuresis, it is hot and suffocating clearly that eliminating inflammation and expelling toxin makes it part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels uterus, and water is wet gets profit, and heat is malicious must be removed; Compendium of Material Medica cloud: " Patrinia scaniosaefolia, the broken blood of kind apocenosis, therefore Zhong Jing controls carbuncle, and ancient prescription married woman section is all with it, so that the thing being easy to get, and descendant does not know use, lid does not meet the knowledgeable's ear. " test the phagocytic activity proving that Herba Patriniae, Stem of Sargentgloryvine can strengthen skein cell and white corpuscle, it is to increase the anti-infectivity of body, enhancing antibody is formed and improves N,O-Diacetylmuramidase level in serum, thus reaches the object of antisepsis and anti-inflammation. And with peach kernel, red sage root promoting blood circulation to remove blood stasis, tonifying blood and regulating menstruation, thus become clearing heat and promoting diuresis altogether, stasis-dispelling and pain-killing, Radix Angelicae Sinensis, Herba Andrographis is mended and not dry, is beneficial to effect of temperature compensation. The real heat of the clear blood system of radix paeoniae rubrathe energy, it is treat in gynaecology the good medicine become silted up that loose hemostasis is detained real. Theory according to the traditional Chinese medical science " the many void of prolonged illness, the many stasis of bloods of prolonged illness ", treatment is principle taking strengthening vital QI to eliminate pathogenic factors, under really being treated dysmenorrhes band, the good recipe of the various inflammation such as pelvic cavity, vagina, annex.

Peach kernel is bitter, sweet, puts down the special medicine for blood hemostasis closes. Bitter to let out stagnant blood, the new blood of Gan Yisheng. " medicineization justice ": peach kernel, bitter can rush down blood-head, and it is dry that body profit can grow intestines. If gross weight grinds broken multiplex, walk Liver Channel, main broken storage blood, water month by month, and pain all over, four limbs wood numbness, left hemiplegia, left podalgia notably, is relaxed through promoting circulation of blood of invigorating blood circulation with it, the merit having the stasis of blood raw new, if few use is mashed in peeling, enters large intestine, control blood depletion just to close, blood is dry just difficult, moistens the cool blood of profit and blood with it, the power having out knot logical stagnant.

The red sage root is bitter, micro-cold. The thoughts of returning home, Liver Channel. Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness. For menoxenia, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, and hot numbness pain, sore swells and ache, dysphoria and insomnia. For sternal rib hypochondriac pain, rheumatic arthralgia, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, menoxenia, through closing dysmenorrhoea, postpartum stasis of blood pain etc. Treatment sternal rib pain, abdominal mass caking, and menoxenia, through amenorrhoea pain there is good effect. " detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it. The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.

Stem of Sargentgloryvine bitter is put down, and enters large intestine channel. Function is clearing heat and detoxicating, promoting blood circulation to remove blood stasis, wind dispelling insecticide. For abdominalgia with intestinal abscess, rheumatic arthralgia, traumatic pain, dysmenorrhes, dysentery characterized by blood in the stool, blood drenches, the diseases such as infantile malnutrition due to digestive disturbances or intestinalparasites worm pain.

Radix paeoniae rubrathe bitter, micro-cold. Return Liver Channel. Function cures mainly clearing heat and cooling blood, blood stasis removing analgesic. For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion with pain and swelling of the eye, hypochondriac pain due to stagnation of liverQI, through closing dysmenorrhoea, abdominal mass is suffered from abdominal pain, injury from falling down, and carbuncle swells sore. The radix paeoniae rubrathe can blood system be real warm clearly, and loose hemostasis is detained. This product function and the root bark of tree peony are close, thus normal be use with root bark of tree peony mutual reinforcement between. But the effect of root bark of tree peony clearing heat and cooling blood is better, can the real heat of blood system clearly, fever due to yin deficiency can be controlled again; And the radix paeoniae rubrathe can only be used for the real heat of blood system, it is good at promoting blood circulation to remove blood stasis.

Yunnan Caulis Spatholobi property is bitter, sweet, temperature. Return liver, kidney channel, enrich blood, invigorate blood circulation, logical network. For menoxenia, the deficiency of blood is sallow, paralysis and numbness, and rheumatic arthralgia is activated blood and relaxed tendons; Nourishing blood for regulating menstruation, " A Supplement to the Compendium of Materia Medica " is carried it and can be cured numb in every limb; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhoea.

A kind of traditional Chinese medicine material of Flos Campsis, has promoting circulation of blood and goes the stasis of blood, cooling blood, expelling wind profit wet, and clearing heat and detoxicating, taste is sad, and cold nature returns liver, pericardium warp, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind. Cure mainly menoxenia, through close abdominal mass, postpartum swollen, the skin pruritus of breast. " Amplification on Materia Medica addendum ": Flos Campsis, also, and tonifying yin victory is very, is stamped and keeps and walk alone for the key medicine controlling pain in blood, in married woman side multiplex how. " Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, apocenosis myogenic, controls red dysentery characterized by white mucous stool.

Herba Patriniae nature and flavor hardship is flat, has effect clearing heat and detoxicating, the broken stasis of blood of apocenosis. Can cure acute appendicitis, lower dysentery, leucorrhea with red and white discharge, postpartum the stagnant stomachache of the stasis of blood, conjunctival congestion with pain and swelling of the eye. Enter stomach, large intestine, Liver Channel. Cure mainly clearing heat and detoxicating, the carbuncle that disappears apocenosis, blood circulation promoting competent silt. For acute appendicitis, lung carbuncle and sore and toxic, the stagnant caused chest and abdomen pain of the real hot stasis of blood, postpartum, the stagnant stomachache of the stasis of blood waited disease.

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous. Return kidney channel. Cure mainly warming the kidney to invigorate YANG, eliminating dampness, dispel the wind, kill worm. For impotence, Gong Leng, under cold-dampness band, arthritis with fixed pain caused by dampness pain in the back; Control vulval eczema outward, married woman's pruritus vulvae; Trichomonal vaginitis is gynecological external use good medicine. " Bencao Jingshu " carries: Fructus Cnidii, and bitter is put down; " not Lu " be pungent sweet nontoxic; Modern its smell in detail, when holding concurrently, temperature is dry, and sun is also. Therefore housewife people's the moon swells and ache, man's impotence is wet itches, and except numbness gas, profit joint, dislikes sore. " not Lu " warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, makes us there is son. Lid can dehumidify with tongue, and temperature can fall apart cold, pungent can moisten kidney, sweet can beneficial spleen, therefore all cold of insufficiency type of married woman man can be removed and wet sick. Cold-dampness was both removed, then disease is gone, performance Yiyang, thus can disease, and have help also.

The Fruit of Belveder is cold in nature, and taste is pungent, bitter. Energy clearing heat and promoting diuresis, dispellings wind and arresting itching. For under difficulty and pain in micturition, pruritus vulvae band, the disease such as rubella, eczema, skin pruritus. " key medicine divides agent " carries: " enter kidney, bladder two warp. Diuresis, clearing away damp-heat. Controlling dysuria, gonorrhoea, under band, hernia, rubella, sore poison, mange, private parts is wet itches.

Indigo naturalis has heat-clearing, cool blood, effect of removing toxic substances, and property is sweet, flat, nontoxic, enters liver, lung, stomach warp. Clearing heat and detoxicating, cool blood, arresting convulsion, for maculae caused by violent heat pathogen, blood-head tells nosebleed, pectoralgia hemoptysis, aphtha, mumps, carries according to " key medicine divides agent ": except thermal detoxification, and holding concurrently can cool blood. " Thunder God concocts property of medicine solution " load: " enter liver, spleen two warp. "

Taraxacum is the Chinese medicine commonly used simply, and its pharmaceutical use is loaded various medical book early. Its all herbal medicine, containing compositions such as taraxasterol, taraxerol, taraxacum bitter principle, coffic acid, choline, synanthrin. The property sweet micro-hardship of flat taste. Can be clearing heat and detoxicating, dispersing swelling and dissipating binds. Compendium of Material Medica is recorded: " heat-clearing poison, helping digestion poison, disappearing, evil is swollen, tuberculosis, malignant boil are swollen for Detoxicating food-poisoning, loose stagnant gas. " taraxacum hides sweet flat, its property is nontoxic. When being enter stomach into liver, the key medicine of antipyretic cool blood.

Herba Andrographis is acanthaceous plant Herba Andrographis (Andrographispaniculata(Burm.f.) Nees) full grass or leaf. Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, gold vanilla, gold tack, India's grass, eel grass etc. Bitter, cold in nature. The thoughts of returning home, lung, large intestine, bladder warp. There are clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect. Curing mainly bacillary dysentery, urinary tract infections, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external application can treat sore furuncle swollen poison, trauma infection contamination etc. " Guangxi herbal medicine ": stop blooding cool blood, and removing toxic substances and promoting tissue regeneration, controls lung abscess, stomatitis.

Yunnan Caulis Spatholobi property is bitter, sweet, temperature. Return liver, kidney channel, enrich blood, invigorate blood circulation, logical network. For menoxenia, the deficiency of blood is sallow, paralysis and numbness, and rheumatic arthralgia is activated blood and relaxed tendons; Nourishing blood for regulating menstruation, " A Supplement to the Compendium of Materia Medica " is carried it and can be cured numb in every limb; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhoea. External application is gynaecology's good medicine that invigorating blood circulation is become silted up.

Raspberry plant can be used as medicine, and has multiple drug value, and its fruit has the effect of kidney invigorating and YANG supporting. Raspberry seed oil belongs to unsaturated fatty acids, can promote that the severe that of prostatic secretions covers. Effect: liver-kidney tonifying, controlling nocturnal emission with astringent drugs contracting urine, bright order. Making observation index with the vaginal smear of rat, rabbit and inner membrance section, raspberry seemingly has estrogen-like effects. Bacteriostatic action 100% decoction beats hole method with dull and stereotyped, staphylococcus is had restraining effect, vibrio cholerae is also had restraining effect. The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, raspberry seemingly has estrogen-like effects.

Motherwort Herb taste is arduous, cool. Invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water. Treatment menoxenia, threatened abortion is had difficult labour, retention of placenta, puerperal blood faints, and hemostasis is suffered from abdominal pain, and metrorrhagia and metrostaxis, rushes down blood at hematuria, and carbuncle swells sore. Motherwort Herb alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg. Intravenous rabbit injection syringic acid.delta.-guanidinobutyl ester 1mg/kg, it is seen that urine volume significantly increases. Syringic acid.delta.-guanidinobutyl ester can make rabbit blood suspension generation hemolytic action when higher concentration. Syringic acid.delta.-guanidinobutyl ester infusion tube dilution method 1:13-1:10, to being permitted Lan Shi hair bacterium, wool sample sporidiole bacteria, red Epidermophyton, starlike nocadia all have restraining effect. Intestinal bacteria, dysentery bacterium, by dull and stereotyped paper disk method, are had restraining effect by Motherwort Herb decoction. Motherwort Herb can go to become silted up life newly, promoting blood flow to regulate menstruation, containing the various trace elements such as selenium, manganese, can be anti-oxidant, anti-aging, and there is pretty good beneficial face beauty treatment, anti-ageing anti-old effect.

The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions. Cure mainly the diseases such as febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, the swollen furuncle sore of carbuncle. The clinical application of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs. We are by the strong feature of broad-spectrum antibacterial action, are used in fungus culture miscellaneous bacteria and infect special severe, fine by root of large-flowered skullcap extracting solution effect. " Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: bitter is so eliminating dampness; Cloudy cold so victory is hot, therefore main all heat. All hot persons, heat symptoms caused by an exopathgen are with all over heat also, jaundice, intestines are out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover. Bitter cold can except damp and hot, so small intestine profit and water from by, source is clearly then flowed also clean. The blood person of closing, real heat is at blood system, i.e. hot human blood room, makes us obstructed through closing, damp and hot solution, then Ying Qi is clearly and voluntarily also. Disliking sore subcutaneous ulcer erosion person, blood-head then stays knot, and is that the swollen stain of carbuncle is also rotten: fire ulcer person, also, cool blood is except warm for internal heat blood trouble, then self-healing is also. The root of large-flowered skullcap has anti-allergic and anti-inflammatory action: baicaline contained by the root of large-flowered skullcap and scutellarin can obviously suppress the supersensitivity contractile response that antigen produces by sensitized guinea pig rat small intestine in vitro and isolated tracheal, to passive general transformation reactions and the cavy passivity skin allergic reaction of cavy and mouse, baicaline and scutellarin also have restraining effect. The root of large-flowered skullcap has refrigeration function, and most test proves, the effective ingredient baicaligenin of the root of large-flowered skullcap has refrigeration function. The root of large-flowered skullcap has detoxification, and baicaline has obvious detoxification, and this may be owing to, under the effect of beta-glucuronic acid glucoside enzyme, baicaline decomposites glucuronic acid, and caused by being combined with multiple poisonous substance. The LD50 that baicaline 10 milligrams can improve Strychnine reaches 2.5 times, and the hepatic glycogen content making carbon tetrachloride poisoning mouse increases.

White Mulberry Root-bark is the root skin of moraceae plants mulberry MorusalbaL.. Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan. Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema. Cough for lung heat and breathe heavily, the edema of the face, the diseases such as dysuria. " property of medicine opinion ": make, flat. Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, empty labor visitor's heat headache, interior tonifying for the deficiency. " Japan hanako materia medica ": temperature, in tune, lower gas. Dissolving phlegm is quenched the thirst, profit intestine and small intestine, appetizing, and lower food kills abdomen and hides worm, and only cholera is vomited and diarrhoea.

Skunk bush, cures mainly perverse trend fever and chills under the heart, and Wen Zhong, by cold temperature numbness, goes three worms, and clothes have been made light of one's life by commiting suicide strong cloudy benefit essence, five viscera settling, logical nine keys, the merit of stopping dribbling urination for a long time; Take bright order, brute force for a long time all the year round. Skunk bush, has another name called Fructus Corni, medicine jujube, real jujube, fructus corni, meat jujube etc., is the conventional rare traditional Chinese medicine of China, and applicating history is long. It is gentle with its benefit power, establishing-Yang and do not help fire, enriching yin and oiliness diaphragm, convergence and do not stay and evil wait special efficacy to be liked use by successive dynasties medical science. Zhang Zhongjing is that monarch has formulated " JINGUI SHENQI WAN " taking skunk bush. According to chemical analysis, skunk bush contains the effective constituents such as the stronger skunk bush glucoside of physiologically active, tartrate, gallic acid, oxysuccinic acid, tree ester, tannin and multivitamin, have and strengthen immunity, anti-inflammation, the pharmacological action such as antibacterial, be the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice.

The root of herbaceous peony enters liver, the spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, holds back cloudy receipts sweat. Controlling chest and abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, uterine bleeding, under band, married woman's blood closes obstructed, and disappear hemostasis, can lose purulence, benefit woman's blood. " Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, benefit gas, the capable hot disease in sky, pest miasma, and frightened mad, married woman's blood is transported, and intestines wind, rushes down blood, hemorrhoid fistula. Carbuncle on the back, sore scabies, headache, bright order, hot eyes exerts meat. The red many tonifying Qi of look person, white person controls blood.

The pungent micro-hardship of rhizoma cyperi is sweet, and flat function cures mainly: regulate the flow of vital energy Xie Yu, menstruction regulating and pain relieving. For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, maldigestion, menoxenia, through closing dysmenorrhoea, cold hernia stomachache, distending pain of the breast. " detailed outline " carries it: gas cold epidemic disease time loose, and profit three is burnt, Xie Liuyu, and the diet that disappears gathers, and phlegm and retained fluid ruffian is full, and instep swells, abdominal distension, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, lower blood, hematuria, under married woman's uterine bleeding band, the moon waits uncomfortable, all kinds of diseases and ailments in postpartum before tire.

Root of Dahurain angelica meridian distribution of property and flavor: pungent, temperature. Attach to the lung and stomach meridians. Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, eliminating dampness is band only. " Japan hanako materia medica ": control the hot eyes triangular mass of mucous membrane growing from the inner corner of the eye, and mend threatened abortion landing, broken place blood, mends new blood, acute mastitis, carbuncle on the back, scrofula, intestines wind, hemorrhoid fistula, apocenosis, desolation, mange, pain relieving myogenic, goes face defect scar.

Kuh-seng is bitter, cold. The thoughts of returning home, liver, stomach, large intestine, bladder, through heat-clearing and damp-drying drug, kill worm, diuresis. For hot dysentery, have blood in stool, jaundice renal shutdown, leucorrhea with red and white discharge, cloudy swollen pruritus vulvae, eczema, wet sore, skin pruritus, mange leprosy; Control colpitis mycotica outward, often it is combined with golden cypress, be the external use gynaecological good medicine for the treatment of vaginitis.

Rhizome of Glabrous Greenbrier nature and flavor: sweet light are flat. Gui Jing: Liver Channel; Stomach warp; The spleen channel. Function: removing toxic substances, dehumidifying, profit joint. Curing mainly: control syphilis, drench turbid, muscles and bones contraction pain, beriberi, malignant boil treats sore, and carbuncle swells, scrofula

The preparation process of suppository of the present invention is: get red sage root 1000g, Herba Andrographis 1000g, Yunnan Caulis Spatholobi 1000g, Motherwort Herb 1000g, peach kernel 1000g, Herba Patriniae 1000g, Stem of Sargentgloryvine 1000g, radix paeoniae rubrathe 1000g, Flos Campsis 1000g, Williams Elder Twig 1000g, taraxacum 1000g, root of large-flowered skullcap 1000g, Fruit of Belveder 1000g, indigo naturalis 1000g, Fructus Cnidii 1000g, White Mulberry Root-bark 1000g, skunk bush 1000g, raspberry 1000g, root of herbaceous peony 1000g, kuh-seng 1000g, Rhizome of Glabrous Greenbrier 1000g, adds water soaking 30 minutes to 1 hour, heated and boiled 30��40 minutes, filtering, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 30��40 minutes, filters, and filtrate is for subsequent use; Filter residue adds water again, for the third time heated and boiled 30��40 minutes, filters; Three filtrates being combined, heating concentrates to paste, then root of Dahurain angelica 1000g, rhizoma cyperi 1000g steam distillation is extracted, and obtains crystallisate, is mixed in ointment obtained above; Choosing matrix 50 DEG C��60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus. Described suppository matrix used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, polyoxyethylene glycol, lanolin; Described matrix is heating and melting under temperature 50 DEG C��60 DEG C conditions, adds the medicine lotion that described preparation method obtains, and stirring in water bath is even, is mixed into sticky thick liquid, is poured in plastics calibration tube, the cotton bolt of insertion, and cooling and shaping makes bullet-shaped suppository; Described cotton bolt is the cotton bolt of afterbody with cotton thread.

The preparation process of suppository of the present invention can also be: gets red sage root 1500g, Herba Andrographis 1500g, Yunnan Caulis Spatholobi 1500g, Motherwort Herb 1500g, peach kernel 1500g, Herba Patriniae 1500g, Stem of Sargentgloryvine 1500g, radix paeoniae rubrathe 1500g, Flos Campsis 1500g, Williams Elder Twig 1500g, taraxacum 1500g, root of large-flowered skullcap 1500g, Fruit of Belveder 1500g, indigo naturalis 1500g, Fructus Cnidii 1500g, White Mulberry Root-bark 1500g, skunk bush 1500g, raspberry 1500g, root of herbaceous peony 1500g, kuh-seng 1500g, Rhizome of Glabrous Greenbrier 1500g, by described bulk drug, put into after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 order sieves is reaching 30%, collect the raw material fine powder by 100 order sieves for subsequent use. the particulate matter being left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1��2 hour, No. 2 extracting solutions is merged and leaves standstill, No. 2 extracting solutions each 1��2 hour, are merged and leave standstill by the times amount water heating and refluxing extraction that adds 10 by the dregs of a decoction that above-mentioned extraction using alcohol is crossed 2 times. rhizoma cyperi 1500g and root of Dahurain angelica 1500g is distilled crystallization of vaporizing to obtain, is dried to powder, again above-mentioned two kinds of extracting solutions are merged, the filtrate of 1.37 when concentrating under reduced pressure relative density is 80 DEG C, reclaim ethanol, gained filtrate is adjusted proportion to 1.06, stir even after adding the fine powder and crystalline powder sieved, pour in matrix, 50 DEG C��60 DEG C heating and melting, cooling and shaping makes class warhead shape suppository, and the proportioning of described pulvis Chinese patent medicine and matrix is 1: 2��1: 4, described cotton bolt is the cotton bolt of afterbody with cotton thread.

The present invention treats chronic pelvic inflammatory disease Chinese medicine composition, topical agent makes suppository, then get matrix heating and melting, temperature 50 DEG C��60 DEG C, adds the medicine fine powder of the present invention, and stirring in water bath is even, it is mixed into sticky thick liquid, being poured in plastics calibration tube, the cotton bolt of insertion, cooling and shaping makes similar bullet-shaped suppository. General matrix used can be: semi-synthetic fatty acid glyceride, lanolin, polyoxyethylene glycol, the proportioning of medicine fine powder and matrix is 1: 2��1: 4, it is preferably 1: 3, or adopt poloxamer poloxamer as matrix, it has been widely used as the hydrophilic matrix of suppository, have the following advantages: softer than the solubleness of other matrix, quick, drug loading is also higher.

The detailed directions of described suppository is as follows: medicine suppository of the present invention is removed plastics shell, takes out stype, and pull-out afterbody cotton thread, includes vagina deep in by stype, and cotton thread is stayed external, 1 every night, plays pull-out cotton bolt morning next day, and continuous use 7 days is a course for the treatment of.

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test materials:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, the room breeding of Shandong University's biological test. Medicine: suppository of the present invention.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve suppository, are made into peak concentration, by the maximum permission capacity administration of mouse, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, point twice administration (interval half an hour) in one day, each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female. Suppository adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion. In animal fasting (can't help water) after 18 hours, point twice administration (interval half an hour) in one day, each 0.5ml (every ml is containing crude drug 0.36g), total medicine amount is 18g crude drug/kg.d, 300 times of quite clinical adult's 50Kg body weight consumption. Observe 7 days continuously after administration.

Three, test-results:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, seek maximum tolerated dose only, observed interim at 7 days, its appetite of animal, activity, hair look, the mental status etc. are all normal, grow normal, there are no death. Namely select the 300 times of medicine amounts being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test of the present invention is reported

1, experiment purpose: detection suppository is to the stimulation/corrosive nature of laboratory animal skin and intensity

2, materials and methods:

2.1. tested material: title: the present invention washes suppository (embodiment method obtains)

2.2. laboratory animal: one grade of big ear white race rabbit, 10, female, body weight 2.1-2.3kg; There is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. test method:

Its backbone both sides, back are cut by the healthy rabbits selecting skin intact 10 in test for first 24 hours by hair, go hair side to amass left and right each about 4cm �� 4cm. Getting tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm �� 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, and adhesive plaster is fixed. Another side skin is as blank. Closing after 4 hours, remove coverture, and clean with warm water and go residual tested material, 1,24 and 48 hour after removing tested material is observed and is smeared position skin reaction, and marks.

3, experimental result: any erythema does not occur in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: judging according to skin wound repair standards of grading in " disinfection technology standard " (1999), animal skin stimulus intensity is belonged to nonirritant by ointment of the present invention.

Embodiment 3: vaginal mucomembranous irritant test result

1. test method:

After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, it is divided into three groups at random, often organize each 6, be respectively: the comparison of blank, vehicle, suppository group of the present invention (by application liquid 5 times of concentration). It is placed in vehicle control group and tested material treated animal intravaginal with sterile saline and tested material with the sterilizing sliver leaching of suitable size respectively, contacts 6 hours with vaginal mucosa, after 24 hours, put to death animal. Take out local vagina tissue, observe pathology situation.

2, test-results: vaginal mucomembranous irritant test result

Embodiment 4: skin anaphylactic test result

Using suppository of the present invention, carry out inducing and exciting contact test, viewing test mouse after 24 hours and 48 hours, all loseing skin has the phenomenon such as erythema and oedema, with negative control group without difference. Result shows, skin reaction intensity is bordering on zero by this suppository, namely without skin allergic reaction.

Embodiment 5: long term toxicity test data

1, experimental technique

Random for cavy part is become 4 groups, often organizes 15. In guinea pig back backbone both sides, trichogen is evenly coated so that it is depilation scope about 40 square centimeters. Clean trichogen, observe and often organize cavy after 24 hours and be coated with suppository solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observing the generalized case of cavy, experiment is put to death animal after terminating and is carried out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication cavy trunk Qu Mao districts, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer. Medication group and control animals chroma of hair, ingest, the control group no significant difference such as four limbs are movable, blood biochemistry checking, medication group and control group are all in normal range. Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathology. Prompting, local skin and whole body important organ are showed no obvious toxic action by Chinese medicine suppository long-term prescription of the present invention.

Test-results shows: Chinese medicine suppository experiment safety of the present invention. The minimum inhibition concentration of beta streptococcus, streptococcus aureus, intestinal bacteria is 1: 150 by this medicine, gonococcus is 1: 150, Candida albicans is 1: 300, it it is 5 minutes to the time of killing during 1: 20 extent of dilution, it is 10 minutes when 1: 50, it is 20 minutes when 1: 100, it is 40 minutes when 1: 200, be 8 hours when 1: 400.

Pharmacodynamics test

Test 1, medicine of the present invention are on the impact of mouse peritoneal inflammation

Experimental technique: get some amount healthy male mice, body weight is between 18��22 grams, it is divided into 6 groups at random, it is respectively high, medium and low three the dosage groups of suppository of the present invention, ten thousand logical XIAOMI SHUAN groups (the accurate word Z20025663 of traditional Chinese medicines, TongHua WanTong Pharmacy Co., Ltd of manufacturing enterprise), hydrocortisone control group and Normal group. except hydrocortisone group intraperitoneal administration, all the other are the equal vagina administration of group respectively, after the administration of each group 40 minutes, with the 1% blue 4.0mg/kg tail vein injection of she Wen, and simultaneously abdominal injection 0.25% acetic acid 0.4ml/10g, sacrificed by decapitation after 30 minutes, bloodletting, cut open the belly, by sagging for every animal belly, abdominal cavity is repeatedly rinsed with appropriate distilled water, collect washing lotion and adjust to 10ml, move in scale test tube, centrifugal 2500 revs/min, throw out is abandoned after 10 minutes, supernatant liquor adds 0.1N sodium peroxide 0.1ml, its optical density(OD) is surveyed with spectrophotometer 590nm, the amount of oozing out of she Wen is obtained by typical curve. experimental result is in table 1.

Note: compare with Normal group, �� p < 0.05, �� �� p < 0.01; Compare with FUKE QIANJIN PIAN solution, �� p < 0.05, �� �� p < 0.01. From upper table result, each administration group is compared with control group, the amount of oozing out of her Wen orchid all has obvious restraining effect, and (p < 0.05 or p < 0.01, taking hydrocortisone group as the best, is secondly each dosage group of the present invention. The present invention's each dosage group is compared with FUKE QIANJIN PIAN also has obvious otherness, illustrates that her the oozing out of Wen orchid of mouse that acetic acid is caused by suppository of the present invention has obvious restraining effect, and its effect is better than FUKE QIANJIN PIAN, but not as good as hydrocortisone group.

Test 2. in-vitro antibacterial tests

Substratum: broth culture, broth agar culture medium, blood agar, chocolate flat board; Bacterial classification: select the bacterial classifications such as intestinal bacteria, Pseudomonas aeruginosa, streptococcus aureus, Candida albicans, Bacillus proteus, gonococcus, gamma streptococcus, micrococcus catarrhalis; Method: dilution method, by high, medium and low for suppository solution of the present invention dosage meat soup from 1: 5,1:50 to 1: 100 make doubling dilution, often pipe is containing liquid 2ml, 9th pipe is for without medicine comparison, often adding dilution bacterium liquid 1, hatch 18h for 37 DEG C in pipe, visual results is still the minimal inhibitory concentration (MIC) of this medicine in obvious haze-free pipe containing medicine minimum concentration. Gonococcus is poor growth in meat soup, uses chocolate plate dilution method instead and surveys minimal inhibitory concentration. Such as following table:

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Candida albicans	4.135
Gonococcus	11.8
		Gamma streptococcus	27
Pseudomonas aeruginosa	5.95
		Intestinal bacteria	51
Micrococcus catarrhalis	23
		Streptococcus aureus	6.18

Result shows that the minimal inhibitory concentration of intestinal bacteria, Pseudomonas aeruginosa, streptococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, gamma streptococcus is all 5mg/ml by the present invention, and gonococcus is 10mg/ml. Intestinal bacteria, Pseudomonas aeruginosa, streptococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, gamma streptococcus, gonococcus all there is obvious bacteriostatic action.

3. anti-vagina mould test

Substratum is prepared in proportion, packing 4 bottles, be respectively charged into etc. hold physiological saline (blank group), 0.5%, 1%, the suppository solution of the present invention of 2%, be sub-packed in sterility test pipe, often pipe is about 2ml. Get the sample 0.2ml of the bright mould positive of fresh mirror probatio inspectionem pecuoarem, add in above-mentioned 7 not congruent test tubes, send into 37 DEG C of warm casees immediately and put 24��48 hours, opaque is observed after taking-up, without membranoid substance, minimum precipitation, then draw the upper, middle and lower layer observations of every root test tube with aseptic long sucking pipe. Result shows that mould is had very strong killing action by washing lotion of the present invention.

Clinical trial:

1, case selection standard

Undergoing chronic pelvic inflammation 110 example observed altogether. Age structure: 18��30 years old 16 people, 30��40 years old 46 people, 40��50 years old 48 people; The state of an illness distributes: slight 53 people, middle degree 47 people, severe 10 people.

2, the Case definition of disease

2.1. the Western medicine diagnose standard of chronic pelvic inflammatory disease:

(1) symptom: how not obvious a. constitutional symptom is, only has low-heat sometimes, and easily sense is tired waits disease, and neurasthenia symptom can occur in course of disease elder part patient, and such as lassitude, the whole body is uncomfortable, the diseases such as insomnia.

B. chronic inflammatory diseases forms scar adhesion or pelvic cavity hyperemia, underbelly falling inflation, pain can occurs, lumbosacral region swelling and pain, after fatigue of being everlasting, sexual intercourse, increase the weight of before and after menstruation.

C. chronic inflammatory diseases causes pelvic congestion, or affects ovarian function, can cause menoxenia, with menorrhagia or that menostaxis is common; Can there is leucorrhea increasing, in yellow or yellowish water sample; Fallopian tube adhesion obstruction can cause infertile.

(2) sign: uterus is often in hypsokinesis position, and limitation of activity or adhesion are fixed, and during myometritis, can there be tenderness in uterus; If salpingitis, then touch bar rope shape in one or both sides, uterus and increase thick uterine tube, and have mild tenderness; If hydrosalpinx or uterine tube ovarian cysts, then touching Cystic lesions in pelvic cavity one or both sides, how limited activity is, can have mild tenderness; If during pelvic cavity reticular tissue inflammation, one or both sides, uterus have sheet to increase thick, tenderness, or have palace sacrum ligament to increase thick, hardening, tenderness.

Above-mentioned sign at least needs to possess following 2 simultaneously: uterine activity is limited or adhesion is fixed; Attachment area tenderness.

2.2, the Chinese medical discrimination Case definition of chronic pelvic inflammatory disease:

Primary symptom: a. inferior belly gas pain or shouting pain, sore spot is fixed; B. the swollen pain of waist sacrum; C. profuse leukorrhea, look xanthin is thick, has stink. Secondary disease: a. dysmenorrhea increases the weight of, and menstruation increases block, and menostaxis, spiritlessness and weakness, constipation due to dry stool or half congealed and not well, yellow urine, waste heat does not eliminate or low-heat rises and falls. Tongue arteries and veins: red tongue body or dark red, or see petechia or ecchymosis, yellow and greasy fur or greasy in vain, slippery and rapid pulse or string number or string is sliding or string is puckery. Above primary symptom possesses 2, and secondary disease possesses 2, in conjunction with tongue picture, pulse condition and diagnosable.

3, medication ingredient: the medicine using the present invention, i.e. red sage root 15g, Herba Andrographis 15g, Yunnan Caulis Spatholobi 13g, Motherwort Herb 12g, peach kernel 13g, Herba Patriniae 14g, Stem of Sargentgloryvine 14g, radix paeoniae rubrathe 15g, Flos Campsis 12g, Williams Elder Twig 13g, taraxacum 15g, root of large-flowered skullcap 12g, Fruit of Belveder 13g, indigo naturalis 15g, Fructus Cnidii 12g, White Mulberry Root-bark 12g, skunk bush 13g, raspberry 13g, root of herbaceous peony 15g, kuh-seng 15g, Rhizome of Glabrous Greenbrier 15g, root of Dahurain angelica 12g, rhizoma cyperi 13g, makes suppository.

4, administrated method: after the menstrual period, removes plastics shell by medicine suppository of the present invention, takes out stype, and pull-out afterbody cotton thread, includes vagina deep in by stype, and cotton thread is stayed external, 1 every night, plays pull-out cotton bolt morning next day, and continuous use 7 days is a course for the treatment of. It is used in conjunction 4 courses for the treatment of.

5, curative effect judging standard,

5.1, the disconnected standard of tcm symptom curative effect

With reference to nimodipine method: [before (before treatment integration after integration-treatment)/treatment integration] �� 100%. Clinical recovery: TCM symptom score reduces >=90%. Effective: TCM symptom score reduces >=70%. Progressive: TCM symptom score reduces >=30%. Invalid: TCM symptom score reduces < 30%.

5.2, local sign efficacy assessment standard:

Clinical recovery: after treatment, local sign disappears, and integration is 0. Effective: after treatment, local sign obviously alleviates, after treatment, relatively the front integration for the treatment of reduces >=2/3. Progressive: after treatment, local sign alleviates to some extent, and before relatively treating after treatment, integration reduces >=1/3 and < 2/3. Invalid: after treatment, sign increases the weight of without improving or have, after treatment, relatively the front integration for the treatment of reduces < 1/3.

6, efficacy result analysis: see the following form by the curative effect of the suppository of the present invention treatment chronic pelvic inflammatory disease

To sum up, through clinical observation, by the product of the present invention treatment pelvic inflammatory disease, no matter tcm symptom or local sign to patient all achieve good curative effect, tcm symptom curative effect: always there is efficiency to be 96.36%; Local sign curative effect: always have efficiency to be 80.90%.

Specific embodiment 1: palace, 47 years old, patient's sterilization 3 years, the lower dysmenorrhoea of band more than 2 years. Over nearly 1 year serious under yellowish-white band, taste is smelt as of rotten fish, waist abdomen pendant pain, and before menses mistake, look dim matter is dense, and 10d side is clean, and through the swollen pain of presensation perineum and belly, shape, as given birth to a child, pained can't bear, and can must alleviate with tablet for alleviating pain. Patient's tongue is red, yellow and thin fur, thready and rapid pulse string. Gynecologial examination: vulva has produced formula, vaginal congest, rotten in uterine neck lower lip, increase thick tenderness on the right side of annex, palace body size is normal, and leukorrhea mirror is examined: red blood corpuscle (+), purulence ball (+++), card belongs to wet turbid heresy stagnant dai channel of a specified duration, under stagnation of blood stasis and heat becomes band, controlling suitable eliminating dampness, heat-clearing, profit is wet. Use following formula: red sage root 12g, Herba Andrographis 12g, Yunnan Caulis Spatholobi 13g, Motherwort Herb 14g, peach kernel 13g, Herba Patriniae 14g, Stem of Sargentgloryvine 14g, radix paeoniae rubrathe 15g, Flos Campsis 12g, Williams Elder Twig 13g, taraxacum 15g, root of large-flowered skullcap 12g, Fruit of Belveder 13g, indigo naturalis 15g, Fructus Cnidii 12g, White Mulberry Root-bark 12g, skunk bush 13g, raspberry 13g, root of herbaceous peony 15g, kuh-seng 15g, Rhizome of Glabrous Greenbrier 15g, root of Dahurain angelica 12g, rhizoma cyperi 13g, makes suppository. After the menstrual period, medicine suppository of the present invention being removed plastics shell, take out stype, pull-out afterbody cotton thread, includes vagina deep in by stype, and cotton thread is stayed external, 1 every night, plays pull-out cotton bolt morning next day, and continuous use 7 days is a course for the treatment of. It is used in conjunction 4 courses for the treatment of. 4 courses for the treatment of take effect. Gradually feeling that band is lower to reduce, look turns light, and waist abdomen pendant pain obviously alleviates, and re-uses this Chinese medicine preparation and gradually heals three courses for the treatment of.

Specific embodiment 2, Lee, 33 years old, marries and does not give birth to for 4 years always. Readme over the past half year, two sides underbelly secret anguish, pendant pain is more than, and with soreness of waist pain, leukorrhea amount is many, look yellow, menstruation basic law, time susceptible to lose temper due to restlessness, constipation with dry stool, outer institute once examined: right side hydrosalpinx 4 �� 3 �� 2cm, left side hydrosalpinx 5 �� 6 �� 5cm. Suggestion operation, does not agree to, antibiotic therapy half month, symptom is not obviously alleviated. Examine and see: dim red, the tip of the tongue of emaciated physique, tongue nature has petechia, stringy and thready pulse. Two conjunction is examined: retroposition of uterus, Chang great, movable not good enough. Act pain (+), B ultrasonic is pointed out: left side hydrosalpinx 7 �� 5 �� 3cm, right side hydrosalpinx 2 �� 3 �� 3cm. Control suitable promoting blood circulation to remove blood stasis, eleminating phlegm and freeing channels. Use following formula: red sage root 13g, Herba Andrographis 15g, Yunnan Caulis Spatholobi 13g, Motherwort Herb 14g, peach kernel 13g, Herba Patriniae 14g, Stem of Sargentgloryvine 14g, radix paeoniae rubrathe 15g, Flos Campsis 12g, Williams Elder Twig 13g, taraxacum 15g, root of large-flowered skullcap 12g, Fruit of Belveder 13g, indigo naturalis 15g, Fructus Cnidii 14g, White Mulberry Root-bark 12g, skunk bush 13g, raspberry 13g, root of herbaceous peony 15g, kuh-seng 15g, Rhizome of Glabrous Greenbrier 15g, root of Dahurain angelica 12g, rhizoma cyperi 13g, makes suppository. After the menstrual period, medicine suppository of the present invention being removed plastics shell, take out stype, pull-out afterbody cotton thread, includes vagina deep in by stype, and cotton thread is stayed external, 1 every night, plays pull-out cotton bolt morning next day, and continuous use 7 days is a course for the treatment of. Traditional Chinese medicine for outer use external application 5 takes effect the course for the treatment of, obviously alleviates through looking into symptom, and leukorrhea look clear. Check B ultrasonic: ride side attachment no abnormality seen, left side uterine tube increases thick about about 2cm, and after continual cure 3 course for the treatment of, hydrotubation inspection, water flowing process is smooth, becomes pregnant in last Dec, next year natural labor one girl.

Claims (9)

1. treat the Chinese medicine suppository of women's chronic pelvic inflammatory disease for one kind, it is characterized in that, in described Chinese medicine suppository, the weight part number of various raw material is: the red sage root 10��20 parts, Herba Andrographis 10��20 parts, Yunnan Caulis Spatholobi 10��20 parts, Motherwort Herb 10��20 parts, 10��20 parts, peach kernel, Herba Patriniae 10��20 parts, Stem of Sargentgloryvine 10��20 parts, the radix paeoniae rubrathe 10��20 parts, Flos Campsis 10��20 parts, Williams Elder Twig 10��20 parts, taraxacum 10��20 parts, the root of large-flowered skullcap 10��20 parts, the Fruit of Belveder 10��20 parts, indigo naturalis 10��20 parts, Fructus Cnidii 10��20 parts, White Mulberry Root-bark 10��20 parts, skunk bush 10��20 parts, raspberry 10��20 parts, the root of herbaceous peony 10��20 parts, rhizoma cyperi 10��20 parts, the root of Dahurain angelica 10��20 parts, kuh-seng 10��20 parts, Rhizome of Glabrous Greenbrier 10��20 parts.

2.Treat the Chinese medicine suppository of women's chronic pelvic inflammatory disease according to claim 1, it is characterized in that, in described Chinese medicine suppository, the weight part number of various raw material is: the red sage root 10��15 parts, Herba Andrographis 10��15 parts, Yunnan Caulis Spatholobi 10��15 parts, Motherwort Herb 10��15 parts, 10��15 parts, peach kernel, Herba Patriniae 10��15 parts, Stem of Sargentgloryvine 10��15 parts, the radix paeoniae rubrathe 10��15 parts, Flos Campsis 10��15 parts, Williams Elder Twig 10��15 parts, taraxacum 10��15 parts, the root of large-flowered skullcap 10��15 parts, the Fruit of Belveder 10��15 parts, indigo naturalis 10��20 parts, Fructus Cnidii 10��20 parts, White Mulberry Root-bark 10��20 parts, skunk bush 10��20 parts, raspberry 10��20 parts, the root of herbaceous peony 10��20 parts, rhizoma cyperi 10��20 parts, the root of Dahurain angelica 10��20 parts, kuh-seng 10��20 parts, Rhizome of Glabrous Greenbrier 10��20 parts.

3.Treat the Chinese medicine suppository of women's chronic pelvic inflammatory disease according to claim 1, it is characterized in that, in described Chinese medicine suppository, the weight part number of various raw material is: the red sage root 10��20 parts, Herba Andrographis 10��20 parts, Yunnan Caulis Spatholobi 10��20 parts, Motherwort Herb 10��20 parts, 10��20 parts, peach kernel, Herba Patriniae 10��20 parts, Stem of Sargentgloryvine 10��20 parts, the radix paeoniae rubrathe 10��20 parts, Flos Campsis 10��20 parts, Williams Elder Twig 10��20 parts, taraxacum 10��20 parts, the root of large-flowered skullcap 10��20 parts, the Fruit of Belveder 10��20 parts, indigo naturalis 10��15 parts, Fructus Cnidii 10��15 parts, White Mulberry Root-bark 10��15 parts, skunk bush 10��15 parts, raspberry 10��15 parts, the root of herbaceous peony 10��15 parts, rhizoma cyperi 10��15 parts, the root of Dahurain angelica 10��15 parts, kuh-seng 10��15 parts, Rhizome of Glabrous Greenbrier 10��15 parts.

4.The preparation method of a kind of Chinese medicine suppository treating women's chronic pelvic inflammatory disease as according to any one of claims 1 to 3, it is characterized in that, the preparation process of described suppository comprises: by described bulk drug except the root of Dahurain angelica and rhizoma cyperi, all the other add water soaking 30 minutes to 1 hour, heated and boiled 30��40 minutes, filtering, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 30��40 minutes, filters, and filtrate is for subsequent use; Filter residue adds water again, for the third time heated and boiled 30��40 minutes, filters; Three filtrates being combined, heating concentrates to paste, then the root of Dahurain angelica, rhizoma cyperi steam distillation is extracted, and obtains crystallisate, is mixed in the ointment obtained; Choosing matrix 50 DEG C��60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.

5.Treat the preparation method of the Chinese medicine suppository of women's chronic pelvic inflammatory disease according to claim 4, it is characterised in that, described suppository matrix used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, polyoxyethylene glycol, lanolin; Described matrix is heating and melting under temperature 50 DEG C��60 DEG C conditions, adds the medicine lotion that described preparation method obtains, and stirring in water bath is even, is mixed into sticky thick liquid, is poured in plastics calibration tube, the cotton bolt of insertion, and cooling and shaping makes class warhead shape suppository; Described cotton bolt is the cotton bolt of afterbody with cotton thread.

6.The preparation method of a kind of Chinese medicine suppository treating women's chronic pelvic inflammatory disease as according to any one of claims 1 to 3, it is characterised in that, the preparation process of described suppository comprises:

a. described bulk drug is put into except the root of Dahurain angelica and rhizoma cyperi pulverizer grinding and sieving,

b. the particulate matter being left after sieving is put into ethanol heating and refluxing extraction 2 times;

c. get the dregs of a decoction after above-mentioned extraction using alcohol again, the heating and refluxing extraction that adds water 2 times;

d. crystallization of rhizoma cyperi and root of Dahurain angelica distillation being vaporized to obtain, adds in above-mentioned two kinds of extracting solutions, and matrix Mixer pot sets type, and ultraviolet is killed virus.

7.The preparation method of suppository according to claim 6, it is characterized in that, in described step a, described bulk drug is put into except the root of Dahurain angelica and rhizoma cyperi after pulverizer is pulverized and cross 100 order dusting covers, the enable fine powder amount by 100 order sieves reaches 30%, collects the raw material fine powder by 100 order sieves for subsequent use.

8.The preparation method of suppository according to claim 6, it is characterised in that, in described step b, the particulate matter being left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1��2 hour, No. 2 extracting solutions are merged and leaves standstill.

9.The preparation method of suppository according to claim 6, it is characterised in that, in described step c, No. 2 extracting solutions each 1��2 hour, are merged and leave standstill by the heating and refluxing extraction that added water by the dregs of a decoction that above-mentioned extraction using alcohol is crossed 2 times.