CN103721131A

CN103721131A - Traditional Chinese medicinal suppository for treating female chronic pelvic inflammation and preparation method thereof

Info

Publication number: CN103721131A
Application number: CN201310746423.3A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Zhuhai dry Cosmetics Co., Ltd.
Priority date: 2013-12-30
Filing date: 2013-12-30
Publication date: 2014-04-16
Anticipated expiration: 2033-12-30
Also published as: CN103721131B

Abstract

The invention discloses a traditional Chinese medicinal suppository for treating female chronic pelvic inflammation. The traditional Chinese medicinal suppository is prepared from the following raw materials in parts by weight: 10-20 parts of salviae miltiorrhizae, 10-20 parts of common andrographis herb, 10-20 parts of suberect spatholobus stem, 10-20 parts of motherwort, 10-20 parts of peach kernel, 10-20 parts of dahurian patrinia herb, 10-20 parts of sargentgloryvine stem, 10-20 parts of red peony root, 10-20 parts of Chinese trumpet creeper, 10-20 parts of sambucus williamsii hance, 10-20 parts of dandelion, 10-20 parts of scutellaria baicalensis, 10-20 parts of fructus kochiae, 10-20 parts of indigo naturalis, 10-20 parts of fructus cnidii, 10-20 parts of cortex mori radicis, 10-20 parts of dogwood, 10-20 parts of raspberry, 10-20 parts of white peony root, 10-20 parts of rhizoma cyperi, 10-20 parts of angelica root, 10-20 parts of sophora flavescens, and 10-20 parts of rhizoma smilacis glabrae. The traditional Chinese medicinal suppository has the effects of activating blood circulation to remove stasis, eliminating dampness and heat and directly reaching focus, and has a remarkable effect for treatment of chronic pelvic inflammation, chronic annexitis, ovarian cyst, elytritis and other common diseases, has the advantages of quick dissolution and quick drug release, and can achieve the aim of quickly relieving the symptom.

Description

A kind of Chinese medicine suppository for the treatment of women's chronic pelvic inflammatory disease and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine suppository for the treatment of women's chronic pelvic inflammatory disease and preparation method thereof.

Background technology

Female pelvic inflammation refers to the internal genitalia inflammation of (comprising uterus, fallopian tube, the other connective tissue in palace and pelvic peritoneum), both can be confined to certain position of female body, also can relate to whole internal genitalia.If when pathological changes is only confined to fallopian tube and ovary, be commonly referred to adnexitis.According to the pathological development process of female pelvic inflammation, clinical two kinds of acute pelvic inflammatory disease and the chronic pelvic inflammatory diseases that are divided into, in motherland's medical science, this disease belongs to stomachache, invasion of the blood-chamber by heat, leukorrhagia, the category such as infertile.

Chronic pelvic inflammatory disease comprises chronic adnexitis and chronic pelvic paramitritis.The former often shows as tubal wall and thickens hardening, and mucous layer has inflammatory exudate, and fallopian tube sticks together, and tube chamber is blocked, even ovary get involved simultaneously and with fallopian tube break-through, form tubo-ovarian cyst or abscess.Latter is failed thoroughly to cure because of acute inflammation and is developed into chronicly, because tissue is congested, edema, then occurs again proliferation of fibrous tissue, hardening, its inflammation also may be the fan-shaped through pelvic cavity of external diffusion that resembles, therefore uterus is often fixed, and this chronic inflammatory disease state of an illness stubbornness is difficult for radical cure.

Chronic pelvic inflammatory disease main manifestations is lower abdomen falling inflation pain, waist thigh pain, sometimes with rectal tenesmus discomfort, increases the weight of after the fatigue of being everlasting, sexual intercourse, during defecation and before and after menstruation, in addition, also may be with frequent micturition, leucorrhoea grow in quantity, irregular menstruation, dysmenorrhea and the symptom such as infertile.During gynaecological examination, if adnexitis can be in the one or both sides in uterus and increase thick streak thing or sheet block, and with tenderness; As formed hydrosalpinx or cyst of fallopian tube, can touch capsule enclosed mass; If inflammation of pelvic connective tissue, both sides, uterus can thicken and have tenderness in various degree in the form of sheets.

Chronic pelvic inflammatory disease is common gynecological disease, difficult treatment, has the touching feature that does not heal, is easy to recurrence, is a great problem in domestic and international gyniatrics.It is not thorough that chronic pelvic inflammatory disease mostly is acute pelvic inflammatory disease treatment, and patient meets flu, overwork etc. causes premunition low, and source of disease bacterium is active again causes pelvic inflammation recurrence, also has some patients were NAI history, because onset is slow, due to ignoring and treating.Its pathological change is inflammatory exudation in pelvic cavity, organ adhesion, local organization scar hyperplasia, and uterus maintains static.Pelvic congestion is menorrhagia, and ovarian function is damaged menoxenia, and fallopian tube adhesion is infertile, and hydrosalpinx is ovarian cyst.

Motherland's medical science thinks that this disease is many by through row vessels of the uterus in puerperal inanition, invades uterus in affection of exogenous damp pyretic toxicity; Or the spleen damage of suffering from a deficiency of the kidney, retention of water-damp in the body is heat-transformation with the passing of time; Or surfeit delicious food savoury, interior life is damp and hot, bet uterus; Or fire caused by depression of liver-QI, phlegm-fire multiple abscess uterus, causes pelvic cavity viscera inner membrance QI-blood circulation not smooth, and damp pyretic toxicity, phlegm-fire blood stasis are tied mutually, suppuration, infringement pelvic tissue.Because mistake is controlled or wrong treatment, cause outbreak repeatedly, protracted course of disease, organ-tissue adhesion, hypertrophy form abdominal mass enclosed mass.This disease simulataneous insufficiency and excessive, the wet hot phlegm stasis of blood are suffered from mutually each other, and spleen is suffered from a deficiency of the kidney and damaged is it, and wet hot phlegm stasis blocking is stagnant is its mark.

In China and world wide, the sickness rate of women's chronic pelvic inflammatory disease is all in rising trend, grievous injury numerous women's physical and mental health, to life, bring trouble not to the utmost, and treat this persistent ailment, never have effective method.The patient of chronic pelvic inflammatory disease shows effect mostly repeatedly, and touching difficulty more, affects quality of life.Though most patients seek medical advice in many ways, generally poor effect all, causes anxiety, depression, and then further increases the weight of the state of an illness, has a strong impact on work and quality of life.

Summary of the invention

Technical problem to be solved by this invention is, chronic pelvic inflammatory disease, adnexitis is common gynecological disease, mostly be acute pelvic inflammatory disease fail appropriate thoroughly treatment or patient's body constitution poor, due to course of disease delay, this state of an illness is more obstinate.Being used for the treatment of at present this sick medicine has Western medicine, also has Chinese medicine.But these medicines mostly curative effect are not remarkable, have been the effect of the respite state of an illness, and can not reach the object of thorough healing, can only maintain or alleviate the state of an illness, can not effect a radical cure.Therefore make many patient's delay treatments or obstinate repeatedly show effect, cause patient's menoxenia, cause sterile (infertility).The present invention is combination clinical experience for many years on the basis of traditional medicine, adopts modern processing method meticulously to develop.The each effective ingredient science compatibility of the present invention to raw material medicine, the focus of going directly, and instant effect, side effect is little, biocidal property is strong preparation, can efficient solution except patient's misery, reach the object of dispelling disease.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of women's chronic pelvic inflammatory disease, in described Chinese medicine suppository, the parts by weight of various raw materials are: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Andrographis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Leonuris, 10～20 parts, Semen Persicae, 10～20 parts of Herba Patriniae, 10～20 parts of Caulis Sargentodoxae, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Flos Campsiss, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Fructus Kochiae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Cortex Mori, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Cyperis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Rhizoma Smilacis Glabraes.

The Chinese medicine suppository of described treatment women's chronic pelvic inflammatory disease, described in it, in Chinese medicine suppository, the parts by weight of various raw materials can be: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Herba Andrographis, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Leonuris, 10～15 parts, Semen Persicae, 10～15 parts of Herba Patriniae, 10～15 parts of Caulis Sargentodoxae, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Flos Campsiss, 10～15 parts of Ramulus Sambuci Williamsii, 10～15 parts of Herba Taraxacis, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Fructus Kochiae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Cortex Mori, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Cyperis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Rhizoma Smilacis Glabraes.

The Chinese medicine suppository of described treatment women's chronic pelvic inflammatory disease, described in it, in Chinese medicine suppository, the parts by weight of various raw materials can also be: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Andrographis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Leonuris, 10～20 parts, Semen Persicae, 10～20 parts of Herba Patriniae, 10～20 parts of Caulis Sargentodoxae, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Flos Campsiss, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Fructus Kochiae, 10～15 parts of Indigo Naturaliss, 10～15 parts of Fructus Cnidiis, 10～15 parts of Cortex Mori, 10～15 parts of Fructus Corni, 10～15 parts of Fructus Rubies, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Rhizoma Cyperis, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Sophorae Flavescentiss, 10～15 parts of Rhizoma Smilacis Glabraes.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine suppository for the treatment of women's chronic pelvic inflammatory disease, the preparation process of described suppository comprises: by described crude drug except the Radix Angelicae Dahuricae and Rhizoma Cyperi, all the other are soaked 30 minutes to 1 hour, heated and boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds water, and heating, boils 30～40 minutes for the second time, filters filtrate for later use; Filtering residue adds water again, and heated and boiled 30～40 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into paste, then the Radix Angelicae Dahuricae, Rhizoma Cyperi are extracted with steam distillation, obtains crystal, is mixed in ointment obtained above; Choose 50 ℃～60 ℃ heating and melting of substrate, add ointment cooling and shaping obtained above to make class warhead shape suppository, ultraviolet virus killing.

The preparation method of the Chinese medicine suppository of described treatment women's chronic pelvic inflammatory disease, described in it, suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under ℃ condition of temperature 50 C～60, the medicine mastic that adds described preparation method to make, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, inserts tampon, and cooling and shaping is made bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of Chinese medicine suppository for the treatment of women's chronic pelvic inflammatory disease again, and the preparation process of described suppository further comprises:

A. described crude drug is put into except the Radix Angelicae Dahuricae and Rhizoma Cyperi to pulverizer grinding and sieving,

B. particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues after above-mentioned ethanol extraction, add water heating and refluxing extraction 2 times;

D. Rhizoma Cyperi and the Radix Angelicae Dahuricae are distilled to the crystallization of vaporizing to obtain, add in above-mentioned two kinds of extracting solution, substrate Mixer pot sets type, ultraviolet virus killing.

In described step a, described crude drug can be put into except the Radix Angelicae Dahuricae and Rhizoma Cyperi after pulverizer is pulverized and be crossed 100 order dusting covers, the fine powder amount that enable pass is crossed 100 mesh sieves is reaching 30%, collects by the raw material fine powder of 100 mesh sieves standby.

In described step b, particulate matter remaining after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution be merged standing;

In described step c, the medicinal residues that above-mentioned ethanol extraction can be crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.

In described steps d, Rhizoma Cyperi and the Radix Angelicae Dahuricae can be distilled to the crystallization of vaporizing to obtain, be dried to powder; Again above-mentioned two kinds of extracting solution are merged, 1.37 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, after adding the fine powder that sieves and crystalline powder, stir evenly, pour in substrate 50 ℃～60 ℃ heating and melting into, cooling and shaping is made class warhead shape suppository, and the proportioning of described powder Chinese patent medicine and substrate is 1: 2～1: 4; Described tampon is the tampon of afterbody with cotton thread.

The present invention adopts stype and tampon integrated technique, has made up the deficiency of ordinary suppository, and ordinary suppository can not effectively be delivered to the depths of vagina.Due to the self purification of vagina, when having foreign body to exist, can increase liquid secretion, at short notice medicine is got rid of externally, both reduced curative effect, extended again the course for the treatment of, increase expense is polluted again underwear.And the present invention overcomes this technical barrier, the suppository of making can be given full play to curative effect of medication, has safety good, the advantage that feasibility is good, and the focus of going directly, reaches the object that gets rid of illness.

The advantages such as compared with prior art, this technology has convenient drug administration, and medicament is easy to manufacture, with low cost.The present invention has the effect of blood circulation promoting and blood stasis dispelling, eliminating damp-heat, the pelvic inflammatory disease of penting up for the stagnation of QI, and the disease such as disease is seen profuse leukorrhea, hypogastralgia is applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis simultaneously, and effect is remarkable.This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid recovery symptom and treatment.

The specific embodiment

Pelvic inflammatory disease, is equivalent in the disease categories such as " leukorrheal diseases ", " menoxenia " in motherland's medical science, " dysmenorrhea ", " lump in the abdomen ".The pathogenic factor of this disease mostly is after childbirth, miscarriage, gynecilogical operation or menstruation, and blood sinus is open, and careless to some extent, damp and hot evil poison is taken advantage of a weak point, if excess of pathogen healthy energy is also contained, the state of an illness oncoming force is more violent, if evil Sheng is weakened body resistance, acute inflammation situation is very unobvious.How because of mistake, to control wrong treatment and transfer chronic phase to.Clinical the most common with chronic pelvic inflammatory disease person.It is stagnant at uterus, vessels of the uterus that its pathogenesis is turbid damp, damp and hot, the evil poison of cold-damp pents up the stasis of blood, so that meridians impatency is obstructed, functional activity of QI being not smooth, and coagulation of QI-blood forms.Thereby heavy dose of heat-clearing and toxic substances removing for acute stage, the agent of dampness removing blood circulation promoting and blood stasis dispelling.Chronic phase is to be delayed by acute stage, because with the passing of time meridian stasis stagnant, so will be with blood circulation promoting and blood stasis dispelling, heat clearing away, dampness removing are main, drink the product that add QI invigorating, also will differentiate the character of turbid damp, add neatly the medicine of invigorating spleen to remove dampness or heat-clearing and toxic substances removing, warming YANG removing dampness, can not stick to routine.Therefore should tonifying speen and tonifying kidney eliminate the phlegm wet, heat-clearing and toxic substances removing is soothing the liver, blood circulation promoting and blood stasis dispelling eliminating stagnation is basic therapy.

Object of the present invention, is exactly all undesirable for the curative effect of the medicine of pelvic inflammatory disease in gynaecopathia, takes effect slower, large to human body side effect, larger to body of women harm, and easy shortcoming repeatedly, a kind of instant effect of invention production, the medicine that side effect is little, biocidal property is strong, to remove patient's misery.The present invention inherits the medical heritage of motherland, Traditional Chinese Medicine is developed, utilize Chinese herbal medicine resource advantage all over the mountains and plains, develop the Chinese medicine preparation of a kind of specially good effect, safety, convenience, inexpensive, pure natural, in order to treat the common gynecological diseases such as women's various pelvic inflammatory disease, frequently-occurring disease, makes up Western medicine toxic and side effects large, and body of women is endangered to the defects such as dark.Preparation technology of the present invention is simple, and medicine material is cheap, and good effect can reach reasonable social effect and economic interests.The present invention has the effect of blood circulation promoting and blood stasis dispelling, eliminating damp-heat, the pelvic inflammatory disease of penting up for the stagnation of QI, and the disease such as disease is seen profuse leukorrhea, hypogastralgia is applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis simultaneously, and effect is remarkable.This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid recovery symptom and treatment.

Chinese medicine for oral administration of the present invention is selected Flos Campsis, sweet cool, clearing away heat-damp and promoting diuresis, it is hot and suffocating clearly that eliminating inflammation and expelling toxin makes it part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels uterus, water is wet gets profit, pyretic toxicity must remove; < < Compendium of Materia Medica > > cloud: " Herba Patriniae, kind evacuation of pus removing blood stasis, therefore Zhong Jing controls carbuncle; and ancient prescription married woman section all uses it; so that the thing being easy to get, and descendant does not know use, lid is not met the knowledgeable's ear." experimental results show that Herba Patriniae, Caulis Sargentodoxae can strengthen skein cell and leukocytic phagocytic activity, improve body resistance infection, enhancing antibody forms and improves Lysozyme Levels in serum, thereby reaches the object of anti-inflammation.And with Semen Persicae, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, tonifying blood and regulating menstruation, thus become altogether clearing away heat-damp and promoting diuresis, stasis-dispelling and pain-killing, Radix Angelicae Sinensis, Herba Andrographis is mended and not dry, is beneficial to the effect of temperature compensation.The Radix Paeoniae Rubra point excess-heat that can purify the blood, it is the good medicine of silt in treatment gynecological that dissipating blood stasis blood is detained real.According to the theory of the traditional Chinese medical science " many empty, the many stasis of bloods of prolonged illness of prolonged illness ", treat take strengthening vital QI to eliminate pathogenic factors as principle the good recipe of the tangible various inflammation such as dysmenorrhes leukorrhagia, pelvic cavity, vagina, adnexa for the treatment of.

Semen Persicae hardship, sweet, put down the special medicine closing for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood.< < medicineization justice > >: Semen Persicae, bitter in the mouth can rush down heat in blood, and body profit can be grown dryness of the intestine.If it is multiplex that gross weight grinds, walk Liver Channel, main broken blood-retention, water month by month, and pain all over, extremity wood numbness, left hemiplegia, left sufficient patient, relaxes through the promoting the circulation of blood of invigorating blood circulation with it, there is the merit of eliminating blood stasis to promote regeneration of blood, if few use is mashed in peeling, enter large intestine, controlling blood depletion just closes, the dry dyschezia of blood, with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

Radix Salviae Miltiorrhizae hardship, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.< < detailed outline > > carries: Radix Salviae Miltiorrhizae, press the sensible opinion of < < married woman > > cloud, SIWU TANG is controlled gynecopathy, pay no attention to antenatal puerperal, how many through water, all can be general, only taste Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, the stillborn fetus that falls, only metrorrhagia dysentery, regulating menstruation arteries and veins.

Caulis Sargentodoxae bitter in the mouth is flat, enters large intestine channel.Function heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, wind dispelling insecticide.For abdominalgia with intestinal abscess, rheumatic arthralgia, traumatic pain, dysmenorrhes, bloody dysentery, stranguria with blood, the diseases such as infantile malnutrition worm pain.

Radix Paeoniae Rubra bitter in the mouth, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra point excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, therefore normal and Cortex Moutan mutual reinforcement between are use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, point excess-heat that can purify the blood, can control again fever due to yin deficiency; And Radix Paeoniae Rubra can only be used for blood system excess-heat, with promoting blood circulation to remove blood stasis, be good at.

Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, < < A Supplement to the Compendium of Materia Medica > > carries it and can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.

A kind of Chinese medicine material of Flos Campsis, has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. < < Amplification on Materia Medica addendum > >: Flos Campsis, control the key medicine of pain in blood also, and nourishing YIN victory very, be stamped and keep and walk alone, in married woman side multiplex what.The medicine will > > of < < Nanning City: have the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting, control red Hakuri.

Herba Patriniae nature and flavor are bitter flat, have the effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Can cure acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the breast abdomen pain due to the excess-heat stasis of blood is stagnant, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis is gynecological external use good medicine.< < Bencao Jingshu > > carries: Fructus Cnidii, and bitter in the mouth is flat; It is pungent sweet nontoxic that < < does not record > >; Modern its abnormal smells from the patient in detail, when the warm-dryness syndrome of must holding concurrently, sun also.Therefore swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil.< < does not record > > warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can cold expelling, pungently can moisten kidney, sweet can strengthening the spleen, therefore can be except all deficiency and coldness of married woman man disease of viscera connecting with this channel that wets.Cold-damp was both removed, and disease is gone, performance Yiyang, thus disease, and have tonification also.

The Fructus Kochiae is cold in nature, acrid in the mouth, hardship.Energy clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For diseases such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.< < key medicine divides agent > > to carry: " enter kidney, bladder two warps.Diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.

Indigo Naturalis has heat clearing away, removing heat from blood, and the effect of removing toxic substances, and property is sweet, and flat, nontoxic, enter liver, lung, stomach warp.Heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion, for maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, divides agent > > to carry according to < < key medicine: except thermal detoxification, holding concurrently can removing heat from blood.< < Thunder God is concocted property of medicine solution > > and is carried: " enter liver, spleen two warps.”

Herba Taraxaci is the Chinese medicine of commonly using simply, and its medical value is loaded various medical books early.Its all herbal medicine, containing compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.Can heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.< < Compendium of Materia Medica > > records: " Detoxicating food-poisoning, loose stagnant gas, heat clearing away poison, relieving dyspepsia poison, disappear dislike swollen, tuberculosis, furuncle is swollen." Herba Taraxaci hides sweet flatly, its property is nontoxic.When being enters stomach into liver, the key medicine of antipyretic removing heat from blood.

Herba Andrographis is acanthaceous plant Herba Andrographis (Andrographis paniculata(Burm.f.) Nees) herb or leaf.Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.Bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can be treated furuncle toxic swelling, trauma infection contamination etc.< < Guangxi Chinese herbal medicine > >: hemostasis removing heat from blood, removing toxic substances and promoting tissue regeneration, controls lung abscess, stomatitis.

Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, < < A Supplement to the Compendium of Materia Medica > > carries it and can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Fructus Rubi plant can be used as medicine, and has multi-medicament to be worth, and its fruit has the effect of kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote the severe that of prostate secretion to cover.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Observation index is made in vaginal smear and inner membrance section with rat, rabbit, and Fructus Rubi seemingly has estrogen-like effects.The flat board method that burrows for bacteriostasis 100% decoct, has inhibitory action to staphylococcus, and vibrio cholera is also had to inhibitory action.The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, Fructus Rubi seemingly has estrogen-like effects.

Herba Leonuri acrid in the mouth hardship, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.Treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine amount significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis when higher concentration.Leonurine infusion tube dilution method 1:13-1:10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, has inhibitory action to escherichia coli, dysentery bacterium.Herba Leonuri can remove the tissue regeneration promoting that becomes silted up, and promoting blood flow to regulate menstruation contains the various trace elements such as selenium, manganese, and energy antioxidation, anti-aging has pretty good beneficial face beauty treatment, anti-ageing anti-old effect.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in fungal culture miscellaneous bacteria and infect special severity by the strong feature of broad-spectrum antibacterial action, fine by Radix Scutellariae extracting solution effect.< < Bencao Jingshu > >: Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory also, is analysed it, all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from by, source is clearly flowed also clean.The blood person of closing, excess-heat is at blood system, and amenorrhea is made us obstructed in instant heating human blood chamber, damp and hot solution, Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is stayed knot, and is that carbuncle stain is also rotten: acute scleritis person, fire of moxibustion blood trouble also, removing heat from blood heat extraction, spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, passive general allergy to Cavia porcellus and mice and Cavia porcellus passivity skin allergic reaction, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and due to being combined with multiple poisonous substance.10 milligrams of LD50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

Cortex Mori is the root bark of moraceae plants Mulberry Morus alba L..Main product in Anhui, the ground such as Henan, Zhejiang, Jiangsu, Hunan.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.< < property of medicine opinion > >: make, flat.Can control lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, the aqueous vapor that disappears, the headache of asthenia exopathogenic heat, interior tonifying for the deficiency.< < Japan hanako materia medica > >: temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea.

Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, the merit that for a long time clothes have been made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopped dribbling urination; Take for a long time improving eyesight, brute force all the year round.Fructus Corni, has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is the conventional rare Chinese medicine of China, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties use that medical science is liked.Zhang Zhongjing has been formulated " JINGUI SHENQI WAN " take Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as cornin, tartaric acid, gallic acid, malic acid, resin, tannin and the multivitamin that physiologically active is stronger, having the immunity, antiinflammatory of enhancing, the pharmacological action such as antibacterial, is Herba indigoferae Pseudotinctoriae conventional in tcm clinical practice.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood.< < Japan hanako materia medica > >: control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, logical month water, brings down a fever, relieving restlessness, QI invigorating, the hot disease of it row, pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.< < detailed outline > > carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers, separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.< < Japan hanako materia medica > >: control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Radix Sophorae Flavescentis hardship, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment colpitis mycotica, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.

Rhizoma Smilacis Glabrae nature and flavor: sweet light, flat.Gui Jing: Liver Channel; Stomach warp; Spleen channel.Function: removing toxic substances, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, furuncle is treated skin ulcer, carbuncle, scrofula

The preparation process of suppository of the present invention is: get Radix Salviae Miltiorrhizae 1000g, Herba Andrographis 1000g, Caulis Spatholobi 1000g, Herba Leonuri 1000g, Semen Persicae 1000g, Herba Patriniae 1000g, Caulis Sargentodoxae 1000g, Radix Paeoniae Rubra 1000g, Flos Campsis 1000g, Ramulus Sambuci Williamsii 1000g, Herba Taraxaci 1000g, Radix Scutellariae 1000g, Fructus Kochiae 1000g, Indigo Naturalis 1000g, Fructus Cnidii 1000g, Cortex Mori 1000g, Fructus Corni 1000g, Fructus Rubi 1000g, Radix Paeoniae Alba 1000g, Radix Sophorae Flavescentis 1000g, Rhizoma Smilacis Glabrae 1000g, soaks heated and boiled 30～40 minutes 30 minutes to 1 hour, filter filtrate for later use; Filtering residue adds water, and heating, boils 30～40 minutes for the second time, filters filtrate for later use; Filtering residue adds water again, and heated and boiled 30～40 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into paste, then Radix Angelicae Dahuricae 1000g, Rhizoma Cyperi 1000g are extracted with steam distillation, obtains crystal, is mixed in ointment obtained above; Choose 50 ℃～60 ℃ heating and melting of substrate, add ointment cooling and shaping obtained above to make class warhead shape suppository, ultraviolet virus killing.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under ℃ condition of temperature 50 C～60, the medicine mastic that adds described preparation method to make, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, inserts tampon, and cooling and shaping is made bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.

The preparation process of suppository of the present invention can also be: get Radix Salviae Miltiorrhizae 1500g, Herba Andrographis 1500g, Caulis Spatholobi 1500g, Herba Leonuri 1500g, Semen Persicae 1500g, Herba Patriniae 1500g, Caulis Sargentodoxae 1500g, Radix Paeoniae Rubra 1500g, Flos Campsis 1500g, Ramulus Sambuci Williamsii 1500g, Herba Taraxaci 1500g, Radix Scutellariae 1500g, Fructus Kochiae 1500g, Indigo Naturalis 1500g, Fructus Cnidii 1500g, Cortex Mori 1500g, Fructus Corni 1500g, Fructus Rubi 1500g, Radix Paeoniae Alba 1500g, Radix Sophorae Flavescentis 1500g, Rhizoma Smilacis Glabrae 1500g, by described crude drug, put into after pulverizer is pulverized and cross 100 order dusting covers, the fine powder amount that enable pass is crossed 100 mesh sieves is reaching 30%, collect by the raw material fine powder of 100 mesh sieves standby.Particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing; The medicinal residues that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged standing.Rhizoma Cyperi 1500g and Radix Angelicae Dahuricae 1500g are distilled to the crystallization of vaporizing to obtain, be dried to powder; Again above-mentioned two kinds of extracting solution are merged, 1.37 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.06, after adding the fine powder that sieves and crystalline powder, stir evenly, pour in substrate 50 ℃～60 ℃ heating and melting into, cooling and shaping is made class warhead shape suppository, and the proportioning of described powder Chinese patent medicine and substrate is 1: 2～1: 4; Described tampon is the tampon of afterbody with cotton thread.

The present invention treats chronic pelvic inflammatory disease Chinese medicine composition, topical agent is made suppository, get substrate heating and melting, temperature 50 C～60 ℃, add medicine fine powder of the present invention, and stirring in water bath is even, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping is made similar bullet-shaped suppository.General substrate used can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, the proportioning of medicine fine powder and substrate is 1: 2～1: 4, be preferably 1: 3, or adopt poloxamer poloxamer as substrate, it has been widely used as the hydrophilic matrix of suppository, have the following advantages: the dissolubility than other substrate is soft, quick, and drug loading is also higher.

The detailed directions of described suppository is as follows: drug suppository of the present invention is removed to cabinet, take out stype, pull-out afterbody cotton thread, includes stype in vagina deep, and cotton thread is stayed external, and 1 every night, play pull-out tampon morning next day, continuous use 7 days is a course for the treatment of.

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: suppository of the present invention.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, 10 every group, male and female half and half, dissolve suppository, are made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.Suppository adding distil water is dissolved, be made into maximum concentration, by the maximum tolerated dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

LD50 calculate in when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test report of the present invention

1, experiment purpose: detect stimulation/corrosiveness and the intensity of suppository to laboratory animal skin

2, materials and methods:

2.1. tested material: title: the present invention washes suppository (embodiment method makes)

2.2. laboratory animal: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; By Affiliated Hospital of Qingdao University biology department Experimental Animal Center, provided;

2.3. test method:

Select 10 of the healthy rabbits that skin is intact, in test, its spinal column both sides, back were cut in first 24 hours to the left and right each about 4cm × 4cm of unhairing area by hair.During test, get on two layers of gauze that tested material 0.2ml is applied to 2.5cm × 2.5cm, be applied to a side skin of unhairing surface, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Seal after 4 hours, dismantle, and clean and go residual tested material with warm water, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and scoring.

3, experimental result: any erythema does not appear in laboratory animal skin, redness, inflammation phenomenon.

4, brief summary: judge according to skin irritation reaction standards of grading in < < disinfection technology standard > > (1999), ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Embodiment 3: vaginal mucomembranous irritant test result

1. test method:

Laboratory animal quarantine, after 3 days, is selected 18 above-mentioned healthy rabbits, is divided at random three groups, every group each 6, is respectively: blank, excipient contrast, suppository group of the present invention (by 5 times of concentration of application liquid).With suitably big or small sterilizing cotton sliver, soak with sterile saline and tested material and be placed in excipient matched group and the intravaginal of tested material treated animal respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Take out local vagina tissue, observe pathological changes situation.

2, result of the test: vaginal mucomembranous irritant test result

Embodiment 4: skin anaphylactic test result

Use suppository of the present invention, induce and excite contact test, viewing test mice after 24 hours and 48 hours, all loseing skin has the phenomenons such as erythema and edema, with negative control group zero difference.Result shows, this suppository is bordering on zero to dermoreaction intensity, without skin allergic reaction.

Embodiment 5: long term toxicity test data

1, experimental technique

By random Cavia porcellus part, become 4 groups, 15 every group.In guinea pig back spinal column both sides, depilatory is evenly coated, made approximately 40 square centimeters of its depilation scopes.Clean depilatory, observe every group of Cavia porcellus after 24 hours and be coated with respectively suppository solution 0.2,0.4 of the present invention and 0.8ml, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment finishes rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity activity, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine suppository long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Result of the test shows: Chinese medicine suppository experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, the time of killing during to 1: 20 dilution factor is 5 minutes, it within 1: 50 o'clock, is 10 minutes, within 1: 100 o'clock, being 20 minutes, 1: 200 o'clock is 40 minutes, within 1: 400 o'clock, is 8 hours.

Pharmacodynamics test

Test 1, the impact of medicine of the present invention on mouse peritoneal inflammation

Experimental technique: get some healthy male mices, body weight is between 18～22 grams, be divided at random 6 groups, be respectively high, medium and low three the dosage groups of suppository of the present invention, ten thousand logical XIAOMI SHUAN group (the accurate word Z20025663 of traditional Chinese medicines, TongHua WanTong Pharmacy Co., Ltd of manufacturing enterprise), hydrocortisone matched group and Normal groups.Except hydrocortisone group intraperitoneal administration, the equal vagina administration of all the other each groups, after the administration of each group 40 minutes, with the blue 4.0mg/kg tail vein injection of 1% she Wen, and while lumbar injection 0.25% acetic acid 0.4ml/10g, sacrificed by decapitation after 30 minutes, blood-letting, cut open the belly, by sagging every animal abdominal part, repeatedly rinse abdominal cavity with appropriate distilled water, collect washing liquid and adjust to 10ml, move into scale in vitro, centrifugal 2500 revs/min, after 10 minutes, discard precipitate, supernatant adds 0.1N sodium peroxide 0.1ml, survey its optical density with spectrophotometer 590nm, by standard curve, obtain she Wen's seepage discharge.Experimental result is in Table 1.

Note: compare ※ p < 0.05, ※ ※ p < 0.01 with Normal group; With FUKE QIANJIN PIAN solution phase ratio, Δ p < 0.05, Δ Δ p < 0.01.From upper table result, each administration group is compared with matched group, the seepage discharge of her Wen orchid is all had to obvious inhibitory action, and (p < 0.05 or p < 0.01, take hydrocortisone group as best, are secondly the each dosage group of the present invention.The each dosage group of the present invention is compared and is also had obvious diversity with FUKE QIANJIN PIAN, illustrates that her the oozing out of Wen orchid of mice that suppository Dichlorodiphenyl Acetate of the present invention causes has obvious inhibitory action, and its effect is better than FUKE QIANJIN PIAN, but not as good as hydrocortisone group.

Test 2. In vitro Bactericidal Experiments

Culture medium: broth bouillon, broth agar culture medium, blood plate, chocolate flat board; Strain: select the strains such as escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, gonococcus, γ-streptococcus, micrococcus catarrhalis; Method: dilution method, by the high, medium and low dosage of suppository solution of the present invention with meat soup from 1: 5,1:50 to 1: 100 make doubling dilution, every pipe is containing medicinal liquid 2ml, the 9th pipe, for without medicine contrast, adds 1 of dilution bacterium liquid in every pipe, hatch 18h for 37 ℃, perusal result, pastille least concentration is still the minimal inhibitory concentration (MIC) that obvious haze-free pipe is this medicine.Gonococcus is undergrowth in meat soup, uses chocolate plate dilution method instead and surveys minimal inhibitory concentration.As following table:

Bacterial strain	Minimum inhibitory concentration (MIC) (mg/ml)
		Candida albicans	4.135
Gonococcus	11.8
		γ-streptococcus	27
Bacillus pyocyaneus	5.95
		Escherichia coli	51
Micrococcus catarrhalis	23
		Staphylococcus aureus	6.18

Result shows that the present invention is all 5mg/ml to the minimal inhibitory concentration of escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, and gonococcus is 10mg/ml.Escherichia coli, bacillus pyocyaneus, staphylococcus aureus, Candida albicans, Bacillus proteus, micrococcus catarrhalis, γ-streptococcus, gonococcus are all had to obvious bacteriostasis.

3. anti-vagina mould test

Culture medium is prepared in proportion, and 4 bottles of subpackages, are respectively charged into etc. and hold normal saline (blank group), 0.5%, 1%, 2% suppository solution of the present invention, are sub-packed in sterility test pipe the about 2ml of every pipe.Getting fresh microscopy proves the specimen 0.2ml of the mycete positive, add above-mentioned 7 heterogeneities in vitro, sending into immediately 37 ℃ of incubators puts 24～48 hours, after taking-up, observe liquid muddiness, without membranoid substance, minimum precipitation, then with aseptic long sucking pipe, draw the upper, middle and lower layer observed result of every test tube.Result shows that washing liquid of the present invention has very strong killing action to mycete.

Clinical trial:

1, case selection standard

Undergoing chronic pelvic inflammation 110 examples of observing altogether.Age distribution: 18～30 years old 16 people, 30～40 years old 46 people, 40～50 years old 48 people; The state of an illness distributes: slight 53 people, moderate 47 people, severe 10 people.

2, the diagnostic criteria of disease

2.1. the Western medicine diagnose standard of chronic pelvic inflammatory disease:

(1) symptom: how not obvious a. General Symptoms is, only has low grade fever sometimes, the tired grade of susceptible disease, and can there is neurasthenia symptom in course of disease elder's some patients were, as lassitude, the whole body is uncomfortable, the diseases such as insomnia.

B. chronic inflammatory disease forms cicatricial adhesion or pelvic congestion, can occur sagging distention in the smaller abdomen, pain, and lumbosacral region swelling and pain, after the fatigue of being everlasting, sexual intercourse, increase the weight of before and after menstruation.

C. chronic inflammatory disease causes pelvic congestion, or affects ovarian function, can cause menoxenia, common with menorrhagia or menostaxis; Can there is leucorrhoea grow in quantity, be yellow or yellowish water sample; Fallopian tube adhesion obstruction can cause infertile.

(2) sign: uterus is often hypsokinesis position, limitation of activity or adhesion are fixed, and during myometritis, can there be tenderness in uterus; If salpingitis, touches the thick fallopian tube of streak increasing, and has mild tenderness in one or both sides, uterus; If hydrosalpinx or tubo-ovarian cyst, touch the swollen thing of capsule in pelvic cavity one or both sides, how limited activity is, can have mild tenderness; If during the inflammation of pelvic cavity connective tissue, one or both sides, uterus have that lamellar thickens, tenderness, or have uterosacral ligament to increase thick, hardening, tenderness.

Above-mentioned sign at least needs to possess following 2 simultaneously: the limited or adhesion of uterine activity is fixed; Attachment area tenderness.

2.2, the Chinese medical discrimination diagnostic criteria of chronic pelvic inflammatory disease:

Primary symptom: a. inferior belly gas pain or twinge, sore spot is fixed; B. waist sacrum distending pain; C. profuse leukorrhea, yellow skin matter is thick, frowziness.Inferior disease: a. abdominal pain during menstruation increases the weight of, menstruation increases piece, menostaxis, spiritlessness and weakness, constipation due to dry stool or half congealed and not well, yellow urine, waste heat does not eliminate or low thermal fluctuation.Tongue arteries and veins: red tongue or dark red, or see petechia or ecchymosis, and yellow and greasy fur or greasy in vain, slippery and rapid pulse or stringy and rapid pulse or stringy and rolling pulse or string are puckery.Above primary symptom possesses 2, and inferior disease possesses 2, diagnosable in conjunction with picture of the tongue, pulse condition.

3, medication ingredient: use medicine of the present invention, i.e. Radix Salviae Miltiorrhizae 15g, Herba Andrographis 15g, Caulis Spatholobi 13g, Herba Leonuri 12g, Semen Persicae 13g, Herba Patriniae 14g, Caulis Sargentodoxae 14g, Radix Paeoniae Rubra 15g, Flos Campsis 12g, Ramulus Sambuci Williamsii 13g, Herba Taraxaci 15g, Radix Scutellariae 12g, Fructus Kochiae 13g, Indigo Naturalis 15g, Fructus Cnidii 12g, Cortex Mori 12g, Fructus Corni 13g, Fructus Rubi 13g, Radix Paeoniae Alba 15g, Radix Sophorae Flavescentis 15g, Rhizoma Smilacis Glabrae 15g, Radix Angelicae Dahuricae 12g, Rhizoma Cyperi 13g, makes suppository.

4, administrated method: after menstrual phase, drug suppository of the present invention is removed to cabinet, take out stype, pull-out afterbody cotton thread, includes stype in vagina deep, and cotton thread is stayed external, 1 every night, play pull-out tampon morning next day, continuous use 7 days is a course for the treatment of.Be used in conjunction 4 courses for the treatment of.

5, curative effect judging standard,

5.1, the disconnected standard of tcm symptom curative effect

With reference to nimodipine method: [(before treatment after integration-treatment integration) the front integration of/treatment] × 100%.Clinical recovery: TCM symptom score reduces >=90%.Effective: TCM symptom score reduces >=70%.Progressive: TCM symptom score reduces >=30%.Invalid: TCM symptom score reduces < 30%.

5.2, local sign efficacy assessment standard:

Clinical recovery: after treatment, local sign disappears, and integration is 0.Effective: after treatment, local sign obviously alleviates, after treatment, the front integration for the treatment of reduces >=2/3.Progress: after treatment, local sign alleviates to some extent, integration reduction >=1/3 and < 2/3 before treating after treatment.Invalid: after treatment, sign increases the weight of without improving or having, after treatment, the front integration for the treatment of reduces < 1/3.

6, efficacy result analysis: see the following form by the curative effect of suppository in treatment chronic pelvic inflammatory disease of the present invention

To sum up, through clinical observation, treat pelvic inflammatory disease with product of the present invention, no matter the tcm symptom to patient or local sign has all obtained good curative effect, tcm symptom curative effect: total effective rate is 96.36%; Local sign curative effect: total effective rate is 80.90%.

Specific embodiment 1: palace, 47 years old, patient's sterillization 3 years, leukorrhagia dysmenorrhea more than 2 years.Over nearly 1 year, HUANGBAI(sic) leukorrhagia is serious, and taste is stench, waist abdomen pendant pain, and before menses mistake, the dim matter of color is dense, and 10d side is clean, and through presensation perineum and abdominal part distending pain, shape is as given birth to a child, and painedly can't bear, and must can alleviate with tablet for alleviating pain.Patient's red tongue, yellow and thin fur, thready and rapid pulse string.Gynecologial examination: pudendum is presentation, vaginal congest, rotten in cervix uteri lower lip, adnexa right side thickens tenderness, palace body normal in size, leucorrhea microscopy: erythrocyte (+), pyocyte (+++), card belongs to the heresy stagnant dai channel of a specified duration of turbid damp, stagnation of blood stasis and heat becomes leukorrhagia, controls suitable dampness, heat clearing away, dampness removing.Use following formula: Radix Salviae Miltiorrhizae 12g, Herba Andrographis 12g, Caulis Spatholobi 13g, Herba Leonuri 14g, Semen Persicae 13g, Herba Patriniae 14g, Caulis Sargentodoxae 14g, Radix Paeoniae Rubra 15g, Flos Campsis 12g, Ramulus Sambuci Williamsii 13g, Herba Taraxaci 15g, Radix Scutellariae 12g, Fructus Kochiae 13g, Indigo Naturalis 15g, Fructus Cnidii 12g, Cortex Mori 12g, Fructus Corni 13g, Fructus Rubi 13g, Radix Paeoniae Alba 15g, Radix Sophorae Flavescentis 15g, Rhizoma Smilacis Glabrae 15g, Radix Angelicae Dahuricae 12g, Rhizoma Cyperi 13g, makes suppository.After menstrual phase, drug suppository of the present invention is removed to cabinet, take out stype, pull-out afterbody cotton thread, includes stype in vagina deep, and cotton thread is stayed external, and 1 every night, play pull-out tampon morning next day, continuous use 7 days is a course for the treatment of.Be used in conjunction 4 courses for the treatment of.Take effect 4 courses for the treatment of.Gradually feel that leukorrhagia reduces, it is light that color turns, and waist abdomen pendant pain obviously alleviates, and re-uses three convalesces course for the treatment of of this Chinese medicine preparation.

Specific embodiment 2, Lee, 33 years old, the not fertility always in 4 years of marrying.Readme over the past half year, bilateral lower abdomen dull pain, pendant pain is more than, with soreness of waist pain, leucorrhea amount is many, yellow skin, menstruation basic law, time susceptible to lose temper due to restlessness, constipation with dry stool, once examined outer court: right side hydrosalpinx 4 × 3 × 2cm, left side hydrosalpinx 5 × 6 × 5cm.Suggestion operation, does not agree to, antibiotic therapy first quarter moon, and condition of illness is not obviously alleviated.Examine and see: dim red, the tip of the tongue of emaciated physique, body of the tongue has petechia, stringy and thready pulse.Bimanual examination: retroposition of uterus, often large, movable not good enough.Lift pain (+), B ultrasonic prompting: left side hydrosalpinx 7 × 5 × 3cm, right side hydrosalpinx 2 × 3 × 3cm.Control suitable promoting blood circulation to remove blood stasis, eleminating phlegm and freeing channels.Use following formula: Radix Salviae Miltiorrhizae 13g, Herba Andrographis 15g, Caulis Spatholobi 13g, Herba Leonuri 14g, Semen Persicae 13g, Herba Patriniae 14g, Caulis Sargentodoxae 14g, Radix Paeoniae Rubra 15g, Flos Campsis 12g, Ramulus Sambuci Williamsii 13g, Herba Taraxaci 15g, Radix Scutellariae 12g, Fructus Kochiae 13g, Indigo Naturalis 15g, Fructus Cnidii 14g, Cortex Mori 12g, Fructus Corni 13g, Fructus Rubi 13g, Radix Paeoniae Alba 15g, Radix Sophorae Flavescentis 15g, Rhizoma Smilacis Glabrae 15g, Radix Angelicae Dahuricae 12g, Rhizoma Cyperi 13g, makes suppository.After menstrual phase, drug suppository of the present invention is removed to cabinet, take out stype, pull-out afterbody cotton thread, includes stype in vagina deep, and cotton thread is stayed external, and 1 every night, play pull-out tampon morning next day, continuous use 7 days is a course for the treatment of.Chinese medicine for outer use external application takes effect for 5 courses for the treatment of, through looking into symptom, obviously alleviates, and leucorrhea color is clear.Check B ultrasonic: right side adnexa no abnormality seen, left side fallopian tube increases thick about 2cm left and right, after 3 courses for the treatment of of continual cure, hydrotubation inspection, water flowing process is smooth, in last Dec, becomes pregnant, next year natural labor one girl.

Claims

1. treat the Chinese medicine suppository of women's chronic pelvic inflammatory disease for one kind, it is characterized in that, in described Chinese medicine suppository, the parts by weight of various raw materials comprise: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Andrographis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Leonuris, 10～20 parts, Semen Persicae, 10～20 parts of Herba Patriniae, 10～20 parts of Caulis Sargentodoxae, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Flos Campsiss, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Fructus Kochiae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Cortex Mori, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Cyperis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Rhizoma Smilacis Glabraes.

2. treat according to claim 1 the Chinese medicine suppository of women's chronic pelvic inflammatory disease, it is characterized in that, in described Chinese medicine suppository, the parts by weight of various raw materials are: 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Herba Andrographis, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Leonuris, 10～15 parts, Semen Persicae, 10～15 parts of Herba Patriniae, 10～15 parts of Caulis Sargentodoxae, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Flos Campsiss, 10～15 parts of Ramulus Sambuci Williamsii, 10～15 parts of Herba Taraxacis, 10～15 parts of Radix Scutellariaes, 10～15 parts of the Fructus Kochiae, 10～20 parts of Indigo Naturaliss, 10～20 parts of Fructus Cnidiis, 10～20 parts of Cortex Mori, 10～20 parts of Fructus Corni, 10～20 parts of Fructus Rubies, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Cyperis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Sophorae Flavescentiss, 10～20 parts of Rhizoma Smilacis Glabraes.

3. treat according to claim 1 the Chinese medicine suppository of women's chronic pelvic inflammatory disease, it is characterized in that, in described Chinese medicine suppository, the parts by weight of various raw materials are: 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Herba Andrographis, 10～20 parts of Caulis Spatholobis, 10～20 parts of Herba Leonuris, 10～20 parts, Semen Persicae, 10～20 parts of Herba Patriniae, 10～20 parts of Caulis Sargentodoxae, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Flos Campsiss, 10～20 parts of Ramulus Sambuci Williamsii, 10～20 parts of Herba Taraxacis, 10～20 parts of Radix Scutellariaes, 10～20 parts of the Fructus Kochiae, 10～15 parts of Indigo Naturaliss, 10～15 parts of Fructus Cnidiis, 10～15 parts of Cortex Mori, 10～15 parts of Fructus Corni, 10～15 parts of Fructus Rubies, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Rhizoma Cyperis, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Sophorae Flavescentiss, 10～15 parts of Rhizoma Smilacis Glabraes.

4. as described in any one in claim 1～3, treat the preparation method of the Chinese medicine suppository of women's chronic pelvic inflammatory disease for one kind, it is characterized in that, the preparation process of described suppository comprises: by described crude drug except the Radix Angelicae Dahuricae and Rhizoma Cyperi, all the other are soaked 30 minutes to 1 hour, heated and boiled 30～40 minutes, filter filtrate for later use; Filtering residue adds water, and heating, boils 30～40 minutes for the second time, filters filtrate for later use; Filtering residue adds water again, and heated and boiled 30～40 minutes is for the third time filtered; Three filtrates are combined, and heating is concentrated into paste, then the Radix Angelicae Dahuricae, Rhizoma Cyperi are extracted with steam distillation, obtains crystal, is mixed in ointment obtained above; Choose 50 ℃～60 ℃ heating and melting of substrate, add ointment cooling and shaping obtained above to make class warhead shape suppository, ultraviolet virus killing.

5. according to the preparation method of Chinese medicine suppository for the treatment of women's chronic pelvic inflammatory disease described in any one in claim 1～4, it is characterized in that, described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under ℃ condition of temperature 50 C～60, the medicine mastic that adds described preparation method to make, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, inserts tampon, and cooling and shaping is made bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.

6. a preparation method for the treatment of the Chinese medicine suppository of women's chronic pelvic inflammatory disease as described in any one in claim 1～3, is characterized in that, the preparation process of described suppository further comprises:

7. the preparation method of suppository according to claim 6, it is characterized in that, in described step a, described crude drug is put into except the Radix Angelicae Dahuricae and Rhizoma Cyperi after pulverizer is pulverized and crossed 100 order dusting covers, the fine powder amount that enable pass is crossed 100 mesh sieves is reaching 30%, collects by the raw material fine powder of 100 mesh sieves standby.

8. the preparation method of suppository according to claim 6, is characterized in that, in described step b, particulate matter remaining after sieving is put into ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution is merged standing.

9. the preparation method of suppository according to claim 6, is characterized in that, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add water heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution is merged standing.

10. the preparation method of suppository according to claim 6, is characterized in that, the crystallization of in described steps d, Rhizoma Cyperi and Radix Angelicae Dahuricae distillation being vaporized to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, 1.37 filtrate when concentrating under reduced pressure relative density is 80 ℃, reclaim ethanol, gained filtrate is adjusted to proportion to 1.60, after the fine powder sieving and crystalline powder are added in filtrate, stir evenly, pour in substrate 50 ℃～60 ℃ heating and melting into, cooling and shaping is made class warhead shape suppository, and the proportioning of described powder Chinese patent medicine and substrate is 1: 2～1: 4; Described tampon is the tampon of afterbody with cotton thread.