CN105535715A - Traditional Chinese medicine skin-wash liquid for treating hot and damp eczema - Google Patents

Traditional Chinese medicine skin-wash liquid for treating hot and damp eczema Download PDF

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Publication number
CN105535715A
CN105535715A CN201610059970.8A CN201610059970A CN105535715A CN 105535715 A CN105535715 A CN 105535715A CN 201610059970 A CN201610059970 A CN 201610059970A CN 105535715 A CN105535715 A CN 105535715A
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China
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weight portion
radix
rhizoma
fructus
weight
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CN201610059970.8A
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Chinese (zh)
Inventor
王兰英
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Qingdao Municipal Hospital
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Qingdao Municipal Hospital
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Priority to CN201610059970.8A priority Critical patent/CN105535715A/en
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a traditional Chinese medicine skin-wash liquid for treating the hot and damp eczema. The traditional Chinese medicine skin-wash liquid is prepared from the following raw medicinal materials: radix scutellariae, rhizoma coptidis, Cortex Phellodendri, herba schizonepetae, alumen, radix sophorae flavescentis, fel ursi, cornu gorais, flos lonicerae, fructus forsythiae, radix trichosanthis, radix et Rhizoma Rhei, Galla Chinensis, raw liquorice root, fructus cnidii, rhizoma smilacis glabrae, raw radix sanguisorbae, herba portulacae, radix paeoniae rubra, cyrtomium rhizome, paniculate swallowwort root, radix angelicae, cortex magnoliae officinalis, tangerine peel, rhizoma atractylodis, radix aucklandiae, rhizoma arisaematis, fructus kochiae, extract of tribulus terrestris, semen persicae, radix rehmanniae, cortex moutan, earthworm, semen coicis and caulis spatholobi. The traditional Chinese medicine skin-wash liquid has the advantage of syndrome differentiation and treatment, overcomes the defect that the traditional Western medicine fails to differentiate patterns of syndromes and realize therapies for syndrome, can substitute the dosage of Western medicine hormone by external application of the traditional Chinese medicine, has the capability of reducing drug dependence, side effect and the like and has better curative effect and satisfaction degree.

Description

The traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema.
Background technology
Eczematosis, because of complexity, is often internal and external reasons interaction result.Endogenous cause of ill is as chronic digestive system disease, psychentonia, insomnia, overtired, emotion changes, endocrine disturbance, infection, dysbolism etc., and exopathogenic factor such as living environment, climate change, food etc. all can affect the generation of eczema.Environmental stimuli as daylight, cold, drying, sweltering heat, hot water is scalded and various animal skin, plant, cosmetics, soap, staple fibre etc. all can bring out.It is a kind of delayed allergy that the complicated inside and outside factor causes.
1. be divided into acute, subacute, chronic three phases by skin lesion performance.
(1) acute eczema: skin lesion is just the pimple of most intensive foxtail millet grain size, papulovesicle or phlysis, substrate flushing, merges in flakes, gradually owing to scratching, pimple, papulovesicle or vesicle top are oozed out and little rotten to the corn face in obvious point-like after scratching, blur margin.As secondary infection, inflammation is more obvious, can form pustule, pus crusts, folliculitis, furuncle etc.Conscious violent pruritus.After being apt to occur in women's head-ornaments, ear, distal limbs, scrotum, crissum etc., multipair title is issued.
(2) subacute eczema: after acute eczema inflammation alleviates, skin lesion based on little pimple, incrustation and squama, rarely seen a small amount of papulovesicle and erosion.Still have violent pruritus.
(3) chronic eczema: often because acute, subacute eczema recurrent exerbation more do not transfer chronic eczema to; Also can start to be chronic eczema.Show as illing skin to thicken, infiltrate, brownish red or pigmentation, rough surface, covers squama, or forms a scab because scratching.Conscious acute pruritus.Be common in the places such as shank, hands, foot, fossa cubitalis, popliteal nest, pudendum, anus.The course of disease is indefinite, easily recurs, and does not prolongedly heal.
2., according to the scope that skin lesion involves, be divided into limitation eczema and the large class of universal eczema two.
(1) limitation eczema: occur over just specific part, namely can name, as hand eczema, pudendum eczema, eczema scrotum, ear eczema, breast eczema, anal eczema, legs eczema etc. at position.
(2) universal eczema: skin lesion is many, general or distribute in the multiple position of whole body.As coin eczema, autosensitization dermatitis, weary fat eczema.
Eczematosis because of complexity, treatment still easy recurrent exerbation after taking a turn for the better, difficult radical cure.Because respectively there is feature at clinical form and position, therefore medication varies with each individual.
1. general control principle
Find possibility inducement, as working environment, living habit, diet, hobby, thought mood etc., and with or without chronic lesion and internal organs disease.
2. in, use therapy
Select antihistaminic antipruritic, two kinds coordinate or are used alternatingly if desired.Universal eczema can oral or injection glucocorticoid, but unsuitable life-time service.
3. Topical therapy
Appropriate dosage forms and medicine is selected according to skin lesion situation.Acute eczema local physiological saline, 3% boric acid or 1:2000 ~ 1:10000 potassium permanganate solution rinse, soak, Calamine Lotion convergence, protection.Subacute, chronic eczema applies suitable glucocorticoid cream, burnt oil-like formulations or immunomodulator, as Tacrolimus paste, pimecrolimus ointment.Secondary infection person's added with antibiotic preparation.
Theoretical based on Chinese traditional treatment, the invention provides a kind of traditional Chinese medicinal lotion being used for the treatment of retention of damp-heat in the interior type eczema, there is the advantage of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, overcome traditional Western medicine cannot distinguish pattern of syndrome carry out verification treatment, by the external of Chinese medicine, the use amount of Western medicine hormone can be substituted, can drug dependence and side effect etc. be reduced, there is better curative effect and satisfaction.
Summary of the invention
The invention provides a kind of traditional Chinese medicinal lotion being used for the treatment of retention of damp-heat in the interior type eczema, there is the advantage of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, overcome traditional Western medicine cannot distinguish pattern of syndrome carry out verification treatment, by the external of Chinese medicine, the use amount of Western medicine hormone can be substituted, can drug dependence and side effect etc. be reduced, there is better curative effect and satisfaction.
For solving the problems of the technologies described above, the invention provides a kind of traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema, its crude drug comprises Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Herba Schizonepetae, Alumen, Radix Sophorae Flavescentis, Fel Ursi, Cornu Naemorhedi, Flos Lonicerae, Fructus Forsythiae, Radix Trichosanthis, Radix Et Rhizoma Rhei, Galla Chinensis, Radix Glycyrrhizae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Radix Sangusorbae, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, the Fructus Kochiae, Fructus Tribuli, Semen Persicae, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi.
Wherein, in described traditional Chinese medicinal lotion, the weight portion of each crude drug is respectively Radix Scutellariae 25 weight portion ~ 40 weight portion, Rhizoma Coptidis 30 weight portion ~ 40 weight portion, Cortex Phellodendri 40 weight portion ~ 55 weight portion, Herba Schizonepetae 20 weight portion ~ 35 weight portion, Alumen 10 weight portion ~ 15 weight portion, Radix Sophorae Flavescentis 20 weight portion ~ 40 weight portion, Fel Ursi 15 weight portion ~ 20 weight portion, Cornu Naemorhedi 10 weight portion ~ 15 weight portion, Flos Lonicerae 25 weight portion ~ 40 weight portion, Fructus Forsythiae 15 weight portion ~ 25 weight portion, Radix Trichosanthis 10 weight portion ~ 15 weight portion, Radix Et Rhizoma Rhei 20 weight portion ~ 30 weight portion, Galla Chinensis 15 weight portion ~ 25 weight portion, Radix Glycyrrhizae 20 weight portion ~ 30 weight portion, Fructus Cnidii 15 weight portion ~ 20 weight portion, Rhizoma Smilacis Glabrae 25 weight portion ~ 35 weight portion, Radix Sangusorbae 20 weight portion ~ 25 weight portion, Herba Portulacae 25 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 20 weight portion ~ 30 weight portion, Rhizoma Osmundae 15 weight portion ~ 20 weight portion, Radix Cynanchi Paniculati 15 weight portion ~ 25 weight portion, the Radix Angelicae Dahuricae 15 weight portion ~ 25 weight portion, Cortex Magnoliae Officinalis 10 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 15 weight portion ~ 30 weight portion, Rhizoma Atractylodis 15 weight portion ~ 25 weight portion, the Radix Aucklandiae 15 weight portion ~ 20 weight portion, Rhizoma Arisaematis 10 weight portion ~ 15 weight portion, the Fructus Kochiae 15 weight portion ~ 25 weight portion, Fructus Tribuli 10 weight portion ~ 15 weight portion, Semen Persicae 15 weight portion ~ 25 weight portion, Radix Rehmanniae 25 weight portion ~ 35 weight portion, Cortex Moutan 15 weight portion ~ 25 weight portion, Pheretima 10 weight portion ~ 15 weight portion, Semen Coicis 25 weight portion ~ 35 weight portion and Caulis Spatholobi 25 weight portion ~ 40 weight portion.
Wherein, in described traditional Chinese medicinal lotion, the weight portion of each crude drug is respectively Radix Scutellariae 30 weight portion ~ 35 weight portion, Rhizoma Coptidis 35 weight portion ~ 40 weight portion, Cortex Phellodendri 45 weight portion ~ 50 weight portion, Herba Schizonepetae 25 weight portion ~ 30 weight portion, Alumen 10 weight portion ~ 15 weight portion, Radix Sophorae Flavescentis 30 weight portion ~ 35 weight portion, Fel Ursi 15 weight portion ~ 20 weight portion, Cornu Naemorhedi 10 weight portion ~ 15 weight portion, Flos Lonicerae 30 weight portion ~ 35 weight portion, Fructus Forsythiae 20 weight portion ~ 25 weight portion, Radix Trichosanthis 10 weight portion ~ 15 weight portion, Radix Et Rhizoma Rhei 25 weight portion ~ 30 weight portion, Galla Chinensis 15 weight portion ~ 20 weight portion, Radix Glycyrrhizae 25 weight portion ~ 30 weight portion, Fructus Cnidii 15 weight portion ~ 20 weight portion, Rhizoma Smilacis Glabrae 30 weight portion ~ 35 weight portion, Radix Sangusorbae 20 weight portion ~ 25 weight portion, Herba Portulacae 30 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 25 weight portion ~ 30 weight portion, Rhizoma Osmundae 15 weight portion ~ 20 weight portion, Radix Cynanchi Paniculati 20 weight portion ~ 25 weight portion, the Radix Angelicae Dahuricae 15 weight portion ~ 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 20 weight portion ~ 25 weight portion, Rhizoma Atractylodis 15 weight portion ~ 20 weight portion, the Radix Aucklandiae 15 weight portion ~ 20 weight portion, Rhizoma Arisaematis 10 weight portion ~ 15 weight portion, the Fructus Kochiae 20 weight portion ~ 25 weight portion, Fructus Tribuli 10 weight portion ~ 15 weight portion, Semen Persicae 20 weight portion ~ 25 weight portion, Radix Rehmanniae 30 weight portion ~ 35 weight portion, Cortex Moutan 15 weight portion ~ 20 weight portion, Pheretima 10 weight portion ~ 15 weight portion, Semen Coicis 30 weight portion ~ 35 weight portion and Caulis Spatholobi 30 weight portion ~ 35 weight portion.
Wherein, in described traditional Chinese medicinal lotion, the weight portion of each crude drug is respectively Radix Scutellariae 35 weight portion, Rhizoma Coptidis 35 weight portion, Cortex Phellodendri 50 weight portion, Herba Schizonepetae 30 weight portion, Alumen 10 weight portion, Radix Sophorae Flavescentis 30 weight portion, Fel Ursi 20 weight portion, Cornu Naemorhedi 10 weight portion, Flos Lonicerae 35 weight portion, Fructus Forsythiae 20 weight portion, Radix Trichosanthis 10 weight portion, Radix Et Rhizoma Rhei 25 weight portion, Galla Chinensis 20 weight portion, Radix Glycyrrhizae 25 weight portion, Fructus Cnidii 15 weight portion, Rhizoma Smilacis Glabrae 30 weight portion, Radix Sangusorbae 20 weight portion, Herba Portulacae 30 weight portion, Radix Paeoniae Rubra 25 weight portion, Rhizoma Osmundae 15 weight portion, Radix Cynanchi Paniculati 20 weight portion, the Radix Angelicae Dahuricae 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Pericarpium Citri Reticulatae 20 weight portion, Rhizoma Atractylodis 20 weight portion, the Radix Aucklandiae 15 weight portion, Rhizoma Arisaematis 10 weight portion, the Fructus Kochiae 20 weight portion, Fructus Tribuli 10 weight portion, Semen Persicae 20 weight portion, Radix Rehmanniae 30 weight portion, Cortex Moutan 20 weight portion, Pheretima 10 weight portion, Semen Coicis 30 weight portion and Caulis Spatholobi 30 weight portion.
Present invention also offers the preparation method of above-mentioned traditional Chinese medicinal lotion, it comprises:
The first step, Herba Schizonepetae, Galla Chinensis, Fructus Cnidii, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, Fructus Tribuli, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi are mixed by weight, use water vapour distillation volatile oil, the another device of the aqueous solution after distillation is collected;
Second step, all the other crude drug components are mixed with the medicinal residues after above-mentioned distillating extracting oil by weight, decoct with water extraction secondary, first time adds this volume of mixture sum 8 times amount soak by water 2 hours, second time adds this volume of mixture sum 5 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.10 ~ 1.15, let cool, adding determining alcohol is that the ethanol of 80% is to reaching 70% containing ethanol contend amount, stir evenly, 2 ~ 5 DEG C of standing cold preservation 24 hours, filter, it is 1.14 ~ 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, add the water dilution of equal volume amounts, stir evenly, 2 ~ 5 DEG C leave standstill cold preservation 24 hours again, filter,
3rd step, the concentrated solution first step being obtained the aqueous solution after distillation obtained with second step mixes, and stirs; And adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
Wherein, the described first step is specially further and Herba Schizonepetae, Galla Chinensis, Fructus Cnidii, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, Fructus Tribuli, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi is mixed by weight, first soak 20min ~ 40min, pour in volatile oil extractor, the way of distillation extracts volatile oil 4 ~ 6h, amount of water is 8-15 times of the mixture weight that this step obtains, and obtains volatile oil.
Useful technique effect
Traditional Chinese medicinal lotion provided by the invention, has the advantage of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, overcome traditional Western medicine cannot distinguish pattern of syndrome carry out verification treatment, by the external of Chinese medicine, the use amount of Western medicine hormone can be substituted, can drug dependence and side effect etc. be reduced, there is better curative effect and satisfaction.
Detailed description of the invention
The invention provides a kind of traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema, its crude drug comprises Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Herba Schizonepetae, Alumen, Radix Sophorae Flavescentis, Fel Ursi, Cornu Naemorhedi, Flos Lonicerae, Fructus Forsythiae, Radix Trichosanthis, Radix Et Rhizoma Rhei, Galla Chinensis, Radix Glycyrrhizae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Radix Sangusorbae, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, the Fructus Kochiae, Fructus Tribuli, Semen Persicae, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi.
For the eczema treatment of retention of damp-heat in the interior pattern of syndrome, Therapeutic Method is in the past main mainly with hormone, can quick symptom relief, reduce skin lesion, reduce pruritus etc., but its toxic and side effects is obvious, recur higher, and traditional oral medicinal herb medicine, when treatment primary disease, heat clearing away easily loses imapirment of the spleen and stomach, damp of being detained; Damp eliminating easily consumes impairment of YIN liquid, wife's calorific potential, and Chinese medicine preparation lotion of the present invention, change tradition mode for oral administration, adopt traditional Chinese medicinal lotion, directly act on affected part, by the misgivings can avoiding oral medicine, its prescription thinking is more effectively simple, embodies the feature that Chinese medicine letter effect is honest and clean.
Traditional Chinese medicinal lotion of the present invention uses Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis dispelling the damp pathogen with drugs of bitter in taste and cold in nature, use Fel Ursi, Cornu Naemorhedi, Radix Trichosanthis, Flos Lonicerae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Rhizoma Osmundae, Radix Cynanchi Paniculati, Herba Portulacae clearing away heat-fire detoxifies, Radix Paeoniae Rubra, Caulis Spatholobi, Radix Sangusorbae, Radix Rehmanniae, Cortex Moutan, Radix Glycyrrhizae clearing away heat and cooling blood, Radix Paeoniae Rubra, Semen Persicae, Radix Et Rhizoma Rhei blood stasis dispersing and fresh blood promoting, use Alumen, Galla Chinensis, Fructus Cnidii, Rhizoma Smilacis Glabrae, Rhizoma Arisaematis, the Fructus Kochiae, Fructus Tribuli killing parasites for relieving itching, alleviate skin lesion symptom, use Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, the Radix Aucklandiae, Semen Coicis, Chinese medicine preparation of the present invention is familiar with theory of Chinese medical science, " blood wind is from going out ", use Pheretima, Herba Schizonepetae, the loose wind medicine such as the Radix Angelicae Dahuricae coordinates blood circulation promoting medicine, antipruritic rapidly, improve symptom, wherein Fructus Tribuli, the Fructus Kochiae, Fructus Cnidii, Pheretima effectively improves allergic symptom, reduce eczema recurrent exerbation.All medicines share, and improve rapidly eczema symptom, substitute the use of Western medicine, reduce the recurrent exerbation of primary disease, are the use of clinical extensive popularization traditional Chinese medicinal lotion of the present invention, provide experimental basis.
Further preferably, described traditional Chinese medicinal lotion is only prepared from by above-mentioned raw materials medicine.
In described traditional Chinese medicinal lotion, the weight portion of each crude drug is respectively Radix Scutellariae 25 weight portion ~ 40 weight portion, Rhizoma Coptidis 30 weight portion ~ 40 weight portion, Cortex Phellodendri 40 weight portion ~ 55 weight portion, Herba Schizonepetae 20 weight portion ~ 35 weight portion, Alumen 10 weight portion ~ 15 weight portion, Radix Sophorae Flavescentis 20 weight portion ~ 40 weight portion, Fel Ursi 15 weight portion ~ 20 weight portion, Cornu Naemorhedi 10 weight portion ~ 15 weight portion, Flos Lonicerae 25 weight portion ~ 40 weight portion, Fructus Forsythiae 15 weight portion ~ 25 weight portion, Radix Trichosanthis 10 weight portion ~ 15 weight portion, Radix Et Rhizoma Rhei 20 weight portion ~ 30 weight portion, Galla Chinensis 15 weight portion ~ 25 weight portion, Radix Glycyrrhizae 20 weight portion ~ 30 weight portion, Fructus Cnidii 15 weight portion ~ 20 weight portion, Rhizoma Smilacis Glabrae 25 weight portion ~ 35 weight portion, Radix Sangusorbae 20 weight portion ~ 25 weight portion, Herba Portulacae 25 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 20 weight portion ~ 30 weight portion, Rhizoma Osmundae 15 weight portion ~ 20 weight portion, Radix Cynanchi Paniculati 15 weight portion ~ 25 weight portion, the Radix Angelicae Dahuricae 15 weight portion ~ 25 weight portion, Cortex Magnoliae Officinalis 10 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 15 weight portion ~ 30 weight portion, Rhizoma Atractylodis 15 weight portion ~ 25 weight portion, the Radix Aucklandiae 15 weight portion ~ 20 weight portion, Rhizoma Arisaematis 10 weight portion ~ 15 weight portion, the Fructus Kochiae 15 weight portion ~ 25 weight portion, Fructus Tribuli 10 weight portion ~ 15 weight portion, Semen Persicae 15 weight portion ~ 25 weight portion, Radix Rehmanniae 25 weight portion ~ 35 weight portion, Cortex Moutan 15 weight portion ~ 25 weight portion, Pheretima 10 weight portion ~ 15 weight portion, Semen Coicis 25 weight portion ~ 35 weight portion and Caulis Spatholobi 25 weight portion ~ 40 weight portion.
Further preferably, in described traditional Chinese medicinal lotion, the weight portion of each crude drug is respectively Radix Scutellariae 30 weight portion ~ 35 weight portion, Rhizoma Coptidis 35 weight portion ~ 40 weight portion, Cortex Phellodendri 45 weight portion ~ 50 weight portion, Herba Schizonepetae 25 weight portion ~ 30 weight portion, Alumen 10 weight portion ~ 15 weight portion, Radix Sophorae Flavescentis 30 weight portion ~ 35 weight portion, Fel Ursi 15 weight portion ~ 20 weight portion, Cornu Naemorhedi 10 weight portion ~ 15 weight portion, Flos Lonicerae 30 weight portion ~ 35 weight portion, Fructus Forsythiae 20 weight portion ~ 25 weight portion, Radix Trichosanthis 10 weight portion ~ 15 weight portion, Radix Et Rhizoma Rhei 25 weight portion ~ 30 weight portion, Galla Chinensis 15 weight portion ~ 20 weight portion, Radix Glycyrrhizae 25 weight portion ~ 30 weight portion, Fructus Cnidii 15 weight portion ~ 20 weight portion, Rhizoma Smilacis Glabrae 30 weight portion ~ 35 weight portion, Radix Sangusorbae 20 weight portion ~ 25 weight portion, Herba Portulacae 30 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 25 weight portion ~ 30 weight portion, Rhizoma Osmundae 15 weight portion ~ 20 weight portion, Radix Cynanchi Paniculati 20 weight portion ~ 25 weight portion, the Radix Angelicae Dahuricae 15 weight portion ~ 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 20 weight portion ~ 25 weight portion, Rhizoma Atractylodis 15 weight portion ~ 20 weight portion, the Radix Aucklandiae 15 weight portion ~ 20 weight portion, Rhizoma Arisaematis 10 weight portion ~ 15 weight portion, the Fructus Kochiae 20 weight portion ~ 25 weight portion, Fructus Tribuli 10 weight portion ~ 15 weight portion, Semen Persicae 20 weight portion ~ 25 weight portion, Radix Rehmanniae 30 weight portion ~ 35 weight portion, Cortex Moutan 15 weight portion ~ 20 weight portion, Pheretima 10 weight portion ~ 15 weight portion, Semen Coicis 30 weight portion ~ 35 weight portion and Caulis Spatholobi 30 weight portion ~ 35 weight portion.
Most preferably, in described traditional Chinese medicinal lotion, the weight portion of each crude drug is respectively Radix Scutellariae 35 weight portion, Rhizoma Coptidis 35 weight portion, Cortex Phellodendri 50 weight portion, Herba Schizonepetae 30 weight portion, Alumen 10 weight portion, Radix Sophorae Flavescentis 30 weight portion, Fel Ursi 20 weight portion, Cornu Naemorhedi 10 weight portion, Flos Lonicerae 35 weight portion, Fructus Forsythiae 20 weight portion, Radix Trichosanthis 10 weight portion, Radix Et Rhizoma Rhei 25 weight portion, Galla Chinensis 20 weight portion, Radix Glycyrrhizae 25 weight portion, Fructus Cnidii 15 weight portion, Rhizoma Smilacis Glabrae 30 weight portion, Radix Sangusorbae 20 weight portion, Herba Portulacae 30 weight portion, Radix Paeoniae Rubra 25 weight portion, Rhizoma Osmundae 15 weight portion, Radix Cynanchi Paniculati 20 weight portion, the Radix Angelicae Dahuricae 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Pericarpium Citri Reticulatae 20 weight portion, Rhizoma Atractylodis 20 weight portion, the Radix Aucklandiae 15 weight portion, Rhizoma Arisaematis 10 weight portion, the Fructus Kochiae 20 weight portion, Fructus Tribuli 10 weight portion, Semen Persicae 20 weight portion, Radix Rehmanniae 30 weight portion, Cortex Moutan 20 weight portion, Pheretima 10 weight portion, Semen Coicis 30 weight portion and Caulis Spatholobi 30 weight portion.
Each crude drug pharmacology is as follows:
Radix Scutellariae: latin name ScutellariaeRadix, bitter in the mouth, cold in nature, enter the heart, lung, stomach, gallbladder, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, antiabortive, the effect of hemostasis, is mainly used in damp and hot caused diarrhoea, dysentery, jaundice, pyretic stranguria; Cough due to lung-heat, thirsty pharyngalgia, also can be used for excessive fetal movement due to heat in pregnancy, and pyretic toxicity pathogenic fire invades the swollen card of carbuncle sore poison of excessive skin.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enter the heart, lung, gallbladder, stomach, large intestine channel, have heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for improving eyesight, be usually used in the fire for the treatment of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, the symptom such as vexed, thirsty.
Cortex Phellodendri: latin name PhellodendriChinensisCortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, and seminal emission, sore swollen toxin, the cards such as eczema pruritus, Cortex Phellodendri has good antibacterial action to multiple gram-positive bacterium.
Herba Schizonepetae: acrid in the mouth, slightly warm in nature, enters lung, Liver Channel, has expelling pathogenic wind from the body surface, declares malicious rash, and effect for the treatment of blood disorders relieving convulsion cures mainly flu cold and heat, headache, eye itching, pharyngalgia, cough, measles, rubella, carbuncle skin ulcer, brigadier, spit blood, clot blood, has blood in stool, metrorrhagia, the card such as postpartum apoplexy, bruise.
Alumen: sour in the mouth, puckery, cold in nature, returns lung; Spleen; Liver; Large intestine; Urinary bladder channel, external can be detoxified parasite killing, dampness removing to stop itchin; Interior hemostasis, antidiarrheal, reduces phlegm.Cure mainly: apoplexy; Epilepsy; Sore throat; Scabies eczema; Swollen ulcer drug; Burn due to hot liquid or fire; Aphtha of the mouth and tongue; Marginal blepharitis eye; Ting discharging ear; Polyp in nose; Skin ulcer hemorrhoid pain; Metrorrhagia; Epistaxis; Bleeding due to trauma; Chronic diarrhea nine dysentery; Leukorrhagia pudendal pruritus; Proctoptosis; The cards such as uterine prolapse.
Radix Sophorae Flavescentis: latin name SophoraeFlavescentisRadix, bitter in the mouth, cold in nature, enter the heart, stomach, large intestine, urinary bladder channel, there is the effect of heat clearing and damp drying, wind dispelling insecticide, be mainly used in damp-heat dysentery, jaundice, stranguria, Radix Sophorae Flavescentis has obvious inhibitory action to dysentery bacterium, escherichia coli, Bacillus proteus, group B streptococcus and staphylococcus aureus.
Fel Ursi: bitter in the mouth; Cold in nature, return liver; Gallbladder; The heart; Stomach warp, has heat-clearing and toxic substances removing; Suppressing the hyperactive liver improving eyesight; Effect of parasite killing hemostasis.Cure mainly jaundice due to damp-heat; Heat-damp in summer dysentery; Calentura infantile convulsion; Cataract; Sore throat; Nose loses; Furuncle; Anal fistula; Infantile malnutrition; Ascarid, multiple hemorrhage card such as grade.
Cornu Naemorhedi: salty in the mouth; Cold in nature, GUIXIN; Liver Channel, has heat clearing away, relieving convulsion, eliminating stasis to stop pain, effect of invigorating blood circulation of stopping blooding.Cure mainly fever of children infantile convulsion; Headache; Puerperal abdonimal pain; The cards such as dysmenorrhea.
Flos Lonicerae: latin name loniceraejaponicaeflos, sweet in the mouth, cold in nature, enter the heart, lung, stomach, large intestine channel, have the effect of heat-clearing and toxic substances removing, holding concurrently can eliminating pathogenic heat from blood to cure dysentery.Be mainly used in affection due to external wind and heat, epidemic febrile disease pyretic toxicity is comparatively contained, or when epidemic febrile disease is still not descending at the part of the body cavity above the diaphragm housing the heart and lungs from the beginning of pathogenic heat; Pyretic toxicity dysentery, stool hematochezia; Fever disease in summer is demonstrate,proved; The carbuncle sore that pyretic toxicity gathers is from the beginning of the, inflammation heat person of swelling and ache etc., Flos Lonicerae has good antipyretic effect, energy antiinflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, newcastle, bacillus pyocyaneus, tubercule bacillus etc.
Fructus Forsythiae: bitter in the mouth, cold nature, enters lung, the heart, small intestine meridian, has heat-clearing and toxic substances removing, effect of dispersing swelling and dissipating binds, for calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.Mongolian medicine is harnessed the Yellow River the cards such as subcutaneous ulcer, intestinal twinge, and Fructus Forsythiae is inhibited to various bacteria, has cooling effect to human body, and has obvious antiinflammatory action.
Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature, enters lung, stomach warp, has clearing away heat and promoting production of body fluid, effect of detumescence and apocenosis, for calentura excessive thirst, lung-heat type cough, the cards such as interior-heat is quenched one's thirst, sore swollen toxin.Radix Trichosanthis has immune system and suppresses and stimulate dual function, inhibited to blood dissolubility streptococcus, streptococcus pneumoniae.
Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach, large intestine, liver, spleen channel, there is effect of purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation, cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention; dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting; spit blood, spitting of blood, epistaxis, has blood in stool, hematuria; blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen; traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, the cards such as scald.
Galla Chinensis: sour in the mouth, puckery, cold in nature, return lung, large intestine, kidney channel, there is effect of astringent or styptic treatment for spontaneous sweating, the supplementing QI for promoting the production of body fluid of convergence, kidney calming, cure mainly: chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; The cards such as carbuncle furuncle, Galla Chinensis energy enhancing body, to the defence capability of nonspecific stimulation, can strengthen the immunologic function of cell, has inhibitory action to this pathogenic bacterium, and can grow by antiviral, has good anti-inflammation hemostasia function.
Radix Glycyrrhizae: sweet in the mouth, property put down, enter 12 warps, have heat-clearing and toxic substances removing, be in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviating medicine stimulates to the toxic and side effects of body or to gastrointestinal, can play QI invigorating neutralization by adding Radix Glycyrrhizae, is in harmonious proportion the effect of each component.
Fructus Cnidii: latin name cnidiifructus, acrid in the mouth, hardship, warm in nature, enter kidney channel, have the effect of warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the impotence in male caused for kidney yang deficiency, woman's cold womb are infertile, the diseases such as cold-damp leukorrhagia or chills and pain of the waist and kness.
Rhizoma Smilacis Glabrae: sweet in the mouth, light, property is put down, Liver Channel; Stomach warp; Spleen channel, has removing toxic substances, dehumidifying, and the effect in sharp joint, cures mainly syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, and furuncle treats skin ulcer, carbuncle, scrofula, syphilis and the limbs contracture caused by mercurialism, the cards such as bones and muscles pain.
Radix Sangusorbae: bitter in the mouth, acid, puckery, cold nature, enter large intestine, liver, stomach warp, there is cooling blood for hemostasis, the effect of removing toxic substances sore, for caused by heat in blood various go out blood disorder, especially part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels intenseness of heat is applicable to, having blood in stool of the absurd row of forcing blood, dysentery, the bottoms such as metrorrhagia go out blood disorder, Radix Sanguisorbae has good anastalsis, to staphylococcus aureus, beta hemolytic streptococcus, streptococcus pneumoniae etc. have stronger inhibitory action, containing tannin in Radix Sanguisorbae, detumescence hemostasis is had to hindering face, astriction, can reduce and ooze out, promote that new skin grows, Radix Sanguisorbae also has the antibacterial action of wide spectrum, the mode adopting charcoal to fry can prevent its hydrolysis of tannins contained by body absorption, strengthen its antibacterial action.
Herba Portulacae: latin name Portulacaeherba, sour in the mouth, cold in nature, return large intestine, Liver Channel, there is heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, and effect of hemostasis removing heat from blood, cures mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.
Radix Paeoniae Rubra: bitter in the mouth, micro-hardship, returns Liver Channel, has removing fire from the liver, clearing away heat and cooling blood, effect of stasis-dispelling and pain-killing, cure mainly the conjunctival congestion and swelling pain of high liver fire, have a dizzy spell, pain in chest and hypochondrium, the fever of the body crimson tongue of the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, and macule is hemorrhage, and blood stasis amenorrhea; The haematemesis hematuria of the absurd row of burning hot flourishing forcing blood; The trip of women's heat in blood is through too much; Various pain caused by blood retardance; The cards such as the furuncle carbuncle of heat in blood poison Sheng.
Rhizoma Osmundae: bitter in the mouth, puckery, cold in nature, returns liver, stomach warp, has parasite killing; Heat clearing away; Removing toxic substances; Effect of cooling blood for hemostasis, for anemopyretic cold; Warm skin eruption; Spit blood; Hemoptysis; Epistaxis; Have blood in stool; Metrorrhagia; Dysentery; The intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.
Radix Cynanchi Paniculati: acrid in the mouth, warm in nature, return liver, stomach warp, there is effect of removing dampness of dispeling the wind, antalgesic-antipruritic, cure mainly rheumatic arthralgia, stomachache distension, toothache, lumbago, fall cards such as flutterring the pain of injury, rubella, eczema.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, enters lung, spleen, stomach warp, has wind-damp dispelling, evacuation of pus of invigorating blood circulation, effect of granulation promoting pain relieving.For cards such as headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.
Cortex Magnoliae Officinalis: bitter in the mouth, pungent, warm in nature, returns spleen channel; Stomach warp; Large intestine channel, has circulation of qi promoting removing food stagnancy; Dampness is except full; Effect of lowering the adverse QI to relieve asthma, cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant stops up QI rising in reverse order; Fullness in the chest such as to be breathed with cough at the card.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, pungent loose logical temperature, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gathers around stagnant, chest and diaphragm feeling of fullness and the card such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi.
Rhizoma Atractylodis: acrid in the mouth, hardship, warm in nature, return spleen, stomach, Liver Channel, have drying damp and strengthening spleen, expelling wind and dampness, effect of improving eyesight, cure mainly the bellyache and diarrhea profit of retention of dampness in middle-JIAO; Incoordination between the spleen and stomach, to epigastric pain, is vomitted indigestion and loss of appetite; The distending pain in the chest and hypochondrium of incoordination between the liver and stomach, the cards such as vomiting with acid regurgitation.
The Radix Aucklandiae: acrid in the mouth, bitter, warm in nature, return spleen, stomach, liver, lung meridian, there are promoting the circulation of QI to relieve pain; Effect of intestinal stasis relieving in tune, cures mainly born of the same parents and coerces distension foot; Abdominal distention; Tell and have loose bowels; Heavily card is waited after dysentery.
Rhizoma Arisaematis: bitter, pungent, temperature, poisonous.Enter lung, liver, spleen channel, drying dampness to eliminate phlegm, expelling wind to relieve convulsion, dispersing swelling and dissipating binds, for the cough caused by pertinacious phlegm damp-phlegm, chest and diaphragm distension, the card such as to have a dizzy spell, for cough due to lung-heat, the sticky person of abundant expectoration yellow skin matter, for cold-phlegm cough, abundant expectoration is rare clearly, oblique for apoplexy accumulation and obstruction of sputum, the stupid fiber crops of brothers, hemiplegia, mouth eye, for wind and cold arthralgia pain, for gnathospasma, the opisthotonus of tetanus, dispersing swelling and dissipating binds is used for furuncle carbuncle, scrofula tuberculosis, for venom.
The Fructus Kochiae: latin name KochiaeFructus, cold in nature, acrid in the mouth, hardship, have clearing away heat-damp and promoting diuresis, effect of dispelling wind for relieving itching, cures mainly the cards such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Fructus Tribuli: latin name TribulusterrestrisL. is pungent, bitter, tepor.Return Liver Channel, suppressing the hyperactive liver is soothing the liver, dispelling pathogenic wind for improving eyesight, and treatment excessive rising of liver-YANG, has a dizzy spell; Distending pain in the chest and hypochondrium, breast closes distending pain; Wind heat is attacked, cataract; Rubella pruritus, the diseases such as vitiligo.
Semen Persicae: bitter in the mouth, sweet, property is put down, GUIXIN, liver, large intestine channel, there is blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, the effect of relieving cough and asthma, for blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, qi depression to blood stasis, channels numbness hinders, arthralgia, traumatic injury, congestion stays under the side of body, hurt like hell, lung abscess, acute appendicitis, the cards such as dryness of the intestine constipation.
Radix Rehmanniae: sweet in the mouth, hardship, cold in nature, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, eliminating blood stasis to promote regeneration of blood, effect of YIN nourishing and the production of body fluid promoting, cures mainly the Kidney-Yin cards of being robbed such as fever of the body thirsty of heat as battalion point; Or calentura later stage low grade fever does not move back; Chronic disease card belongs to yin asthenia generating intrinsic heat person; The thirst and drinking of accumulated heat in the lung and stomach, quenches one's thirst vexed, thirsty few Tianjin that stomach-Yin is injured; The having blood in stool of bleeding due to blood-heat, metrostaxis; The purple black card such as grade of a speckle of heat in blood poison Sheng.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enter the heart, liver, kidney channel, there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.
Pheretima: salty in the mouth, cold in nature, return liver, spleen, urinary bladder channel, have heat clearing away arresting convulsion, dredging collateral is relievingd asthma, effect of diuresis, cures mainly unconsciousness due to high fever, arthralgia, numb limbs and tense tendons, hemiplegia, lung-heat cough with asthma, effect of edema oliguria.
Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.Have the function of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, for weakness of the spleen and stomach, suffer from diarrhoea in loose stool, or vaginal discharge diseases of women, insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.
Caulis Spatholobi: latin name spatholobicaulis, bitter in the mouth, sweet, warm in nature, return liver, kidney channel, have blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, cure mainly the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.
Present invention also offers the preparation method of above-mentioned traditional Chinese medicinal lotion, it comprises:
The first step, mixes by weight by Herba Schizonepetae, Galla Chinensis, Fructus Cnidii, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, Fructus Tribuli, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi, uses water vapour distillation volatile oil;
Second step, all the other crude drug components are mixed with the medicinal residues after above-mentioned distillating extracting oil by weight, decoct with water extraction secondary, first time adds this volume of mixture sum 8 times amount soak by water 2 hours, second time adds this volume of mixture sum 5 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.10 ~ 1.15, let cool, adding determining alcohol is that the ethanol of 80% is to reaching 70% containing ethanol contend amount, stir evenly, 2 ~ 5 DEG C of standing cold preservation 24 hours, filter, it is 1.14 ~ 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, add the water dilution of equal volume amounts, stir evenly, 2 ~ 5 DEG C leave standstill cold preservation 24 hours again, filter,
3rd step, the volatile oil first step being obtained the acquisition after distillation mixes with the concentrated solution that second step obtains, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
The described first step is specially further and Herba Schizonepetae, Galla Chinensis, Fructus Cnidii, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, Fructus Tribuli, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi is mixed by weight, first soak 20min ~ 40min, pour in volatile oil extractor, the way of distillation extracts volatile oil 4 ~ 6h, amount of water is 8-15 times of the mixture weight that this step obtains, and obtains volatile oil.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 traditional Chinese medicinal lotion 1
By Herba Schizonepetae 30g, Galla Chinensis 20g, Fructus Cnidii 15g, Herba Portulacae 30g, Radix Paeoniae Rubra 25g, Rhizoma Osmundae 15g, Rhizoma Atractylodis 20g, Radix Aucklandiae 15g, Rhizoma Arisaematis 10g, Fructus Tribuli 10g, Radix Rehmanniae 30g, Cortex Moutan 20g, Pheretima 10g, Semen Coicis 30g and Caulis Spatholobi 30g mixes, and first soaks 30min, pours in volatile oil extractor, and the way of distillation extracts volatile oil 5h, and add water 3kg, obtains volatile oil, by Radix Scutellariae 35g, Rhizoma Coptidis 35g, Cortex Phellodendri 50g, Alumen 10g, Radix Sophorae Flavescentis 30g, Fel Ursi 20g, Cornu Naemorhedi 10g, Flos Lonicerae 35g, Fructus Forsythiae 20g, Radix Trichosanthis 10g, Radix Et Rhizoma Rhei 25g, Radix Glycyrrhizae 25g, Rhizoma Smilacis Glabrae 30g, Radix Sangusorbae 20g, Radix Cynanchi Paniculati 20g, Radix Angelicae Dahuricae 20g, Cortex Magnoliae Officinalis 15g, Pericarpium Citri Reticulatae 20g, Fructus Kochiae 20g, Semen Persicae 20g mixes with the medicinal residues after above-mentioned distillating extracting oil, decoct with water extraction secondary, first time adds this volume of mixture sum 8 times amount soak by water 2 hours, second time adds this volume of mixture sum 5 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.15, lets cool, and adding determining alcohol is that the ethanol of 80% is to reaching 70% containing ethanol contend amount, stir evenly, 2 DEG C of standing cold preservation 24 hours, filters, and it is 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, add the water dilution of equal volume amounts, stir evenly, 2 DEG C leave standstill cold preservation 24 hours again, filter, mixing obtaining volatile oil above with concentrated solution obtained above, stirring, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
Embodiment 2 traditional Chinese medicinal lotion 2
By Herba Schizonepetae 25g, Galla Chinensis 15g, Fructus Cnidii 15g, Herba Portulacae 30g, Radix Paeoniae Rubra 25g, Rhizoma Osmundae 15g, Rhizoma Atractylodis 15g, Radix Aucklandiae 15g, Rhizoma Arisaematis 10g, Fructus Tribuli 10g, Radix Rehmanniae 30g, Cortex Moutan 15g, Pheretima 10g, Semen Coicis 30g and Caulis Spatholobi 30g mixes, and first soaks 30min, pours in volatile oil extractor, and the way of distillation extracts volatile oil 5h, and add water 3kg, obtains volatile oil, by Radix Scutellariae 30g, Rhizoma Coptidis 35g, Cortex Phellodendri 45g, Alumen 10g, Radix Sophorae Flavescentis 30g, Fel Ursi 15g, Cornu Naemorhedi 10g, Flos Lonicerae 30g, Fructus Forsythiae 20g, Radix Trichosanthis 10g, Radix Et Rhizoma Rhei 25g, Radix Glycyrrhizae 25g, Rhizoma Smilacis Glabrae 30g, Radix Sangusorbae 20g, Radix Cynanchi Paniculati 20g, Radix Angelicae Dahuricae 15g, Cortex Magnoliae Officinalis 15g, Pericarpium Citri Reticulatae 20g, Fructus Kochiae 20g, Semen Persicae 20g mixes with the medicinal residues after above-mentioned distillating extracting oil, decoct with water extraction secondary, first time adds this volume of mixture sum 8 times amount soak by water 2 hours, second time adds this volume of mixture sum 5 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.15, lets cool, and adding determining alcohol is that the ethanol of 80% is to reaching 70% containing ethanol contend amount, stir evenly, 2 DEG C of standing cold preservation 24 hours, filters, and it is 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, add the water dilution of equal volume amounts, stir evenly, 2 DEG C leave standstill cold preservation 24 hours again, filter, mixing obtaining volatile oil above with concentrated solution obtained above, stirring, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
Embodiment 3 traditional Chinese medicinal lotion 3
By Herba Schizonepetae 30g, Galla Chinensis 20g, Fructus Cnidii 20g, Herba Portulacae 35g, Radix Paeoniae Rubra 30g, Rhizoma Osmundae 20g, Rhizoma Atractylodis 20g, Radix Aucklandiae 20g, Rhizoma Arisaematis 15g, Fructus Tribuli 15g, Radix Rehmanniae 35g, Cortex Moutan 20g, Pheretima 15g, Semen Coicis 35g and Caulis Spatholobi 35g mixes, and first soaks 30min, pours in volatile oil extractor, and the way of distillation extracts volatile oil 5h, and add water 3kg, obtains volatile oil, by Radix Scutellariae 35g, Rhizoma Coptidis 40g, Cortex Phellodendri 50g, Alumen 15g, Radix Sophorae Flavescentis 35g, Fel Ursi 20g, Cornu Naemorhedi 15g, Flos Lonicerae 35g, Fructus Forsythiae 25g, Radix Trichosanthis 15g, Radix Et Rhizoma Rhei 30g, Radix Glycyrrhizae 30g, Rhizoma Smilacis Glabrae 35g, Radix Sangusorbae 25g, Radix Cynanchi Paniculati 25g, Radix Angelicae Dahuricae 20g, Cortex Magnoliae Officinalis 20g, Pericarpium Citri Reticulatae 25g, Fructus Kochiae 25g, Semen Persicae 25g mixes with the medicinal residues after above-mentioned distillating extracting oil, decoct with water extraction secondary, first time adds this volume of mixture sum 8 times amount soak by water 2 hours, second time adds this volume of mixture sum 5 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.15, lets cool, and adding determining alcohol is that the ethanol of 80% is to reaching 70% containing ethanol contend amount, stir evenly, 2 DEG C of standing cold preservation 24 hours, filters, and it is 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, add the water dilution of equal volume amounts, stir evenly, 2 DEG C leave standstill cold preservation 24 hours again, filter, mixing obtaining volatile oil above with concentrated solution obtained above, stirring, and adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
The anxious toxicity of embodiment 4 and long term toxicity research
Experimental technique
Adopt short-term passive cutaneous anaphylaxis test to carry out the anxious toxicity research of medicine, adopt long term vascular irritation test to carry out medicine long term toxicity test, and then draw the safety of Chinese medicine preparation of the present invention.
Laboratory animal
Cavia porcellus, male and female half and half, body weight 350 ± 50g (regular grade), SD rat, male and female half and half, body weight 250 ~ 300g (SPF level), New Zealand's white big ear rabbit, body weight 2.5 ± 0.5kg (regular grade), all purchased from Shandong University's Experimental Animal Center, is numbered every animal and weighs, and quarantine is tested after observing 3d.Carry out outward appearance sign, behavioral activity, food ration and body weight to laboratory animal to observe.Feeding environment, room temperature 19 ~ 26 DEG C, temperature difference per day≤4 DEG C, relative humidity 40% ~ 70%, round the clock light and shade alt time 12h/12h.
Experimental drug
Ovalbumin, Hua Ying Bioisystech Co., Ltd
Traditional Chinese medicinal lotion 1 prepared by the embodiment of the present invention 1, being condensed into crude drug concentration is 0.75g/ml solution, and 4 DEG C save backup, return to room temperature during use.
Method and result
Short-term passive cutaneous anaphylaxis test
Get rat 6, be divided into 3 groups at random: positive controls (ovalbumin 3mg/ only), negative control group (0.9% sodium chloride injection), traditional Chinese medicinal lotion group of the present invention, often organize 2.Lumbar injection relative medicine sensitization, the next day 1 time, totally 5 times.Blood sampling in 12nd day after last sensitizing injection, the centrifugal 10min of 2000r/min, separation of serum ,-20 DEG C of preservations, for subsequent use in 2 weeks.Separately get rat 18 to be divided at random 3 groups (method is the same), often organize 6.Back, rat both sides depilation 3cm × 4cm 2, above-mentioned each group of antiserum normal saline dilution becomes 1: 2 and 1: 8, respectively gets 0.1ml difference intradermal injection in the respective sets rat back left and right sides.The common 1ml of 0.5% azovan blue dyestuff that the challenging antigen that after 24h, the intravenous injection of each group is identical with priming dose adds equivalent excites.Each treated animal ventral aorta blood sampling after exciting 20min, centrifuging and taking determination of serum SERUM IgE content, puts to death animal after blood sampling at once, measures the blue spot size of skin inner layer, and diameter > 5mm person is positive.The general status such as the activity of administration treated animal and feed show no obvious abnormalities.
Result: after exciting, all there is locus coeruleus in all 6 rat left and right sides of positive controls, diameter > 5mm, left side locus coeruleus diameter (11.1 ± 2.92) mm, right side locus coeruleus diameter (7.17 ± 2.01) mm, there is not diameter > 5mm locus coeruleus in all the other Group Animals.Compared with negative control group, positive controls SERUM IgE content obviously increases (P < 0.01), and all the other are respectively organized SERUM IgE content and have no obvious change.Above result shows that lotion of the present invention does not cause allotransplantation in rats passive cutaneous anaphylaxis, PCA under this experiment condition.Illustrate that traditional Chinese medicinal lotion short-term heavy dose of the present invention is safe and reliable, instruct clinical heavy dose of medicines such as substituting hormone that uses in a short time to have safety.
Long term vascular irritation test
Get normal healthy rabbits 18, be divided into 3 groups at random, be i.e. high, medium and low dosage group (traditional Chinese medicinal lotion 0.75g/ml, 0.5g/ml, 0.25g/ml prepared by the embodiment of the present invention 1).By 0.5ml/kg body weight, through filtering, dispel suspended impurity, rabbit auricular vein left ear instillation said medicine, dosage 0.9% sodium chloride injections such as auris dextra instillation, administration every day 1 time, continuous 14d, 48h carries out perusal to animal and injection site before administration every day and after last administration, and observed and recorded injection site is with or without the stimulation phenomenon such as red and swollen, congested.After last administration, 48h often organizes and puts to death half animal, with auricular vein injection point to centripetal direction (avoiding injection site) 2cm, get 3 sections of blood vessels continuously together with surrounding tissue, every section of 1cm, fix by 10% formalin, do histopathologic examination, observe venous vascular tissue with or without inflammatory reaction, the even significance such as degeneration, necrosis irritant reaction.Residue animal carries out histopathological examination, again to understand the reversibility of irritative response after continuing to observe 14d.Experimental session, left ear and the auris dextra administration local vascular of laboratory animal are showed no any irritant reaction symptom, and irritant reaction scoring is 0 point.Pathological examination result display administration terminated and at the end of convalescent period, and laboratory animal 0.9% sodium chloride injection control sides and high, medium and low dosage group blood vessel and surrounding tissue are showed no obvious abnormalities.Under this experimental condition, rabbit vein injection gives traditional Chinese medicinal lotion of the present invention high, medium and low dosage, to injection site nonirritant.Traditional Chinese medicinal lotion life-time service safety of the present invention is described, to the clinical life-time service of guidance Chinese medicine preparation of the present invention, provides experimental basis.
Embodiment 5 clinical observation
Eczema is department of dermatologry common clinical, frequently-occurring disease, eczema form of diverse, symmetrical, be easy to ooze out, acute pruritus, touching difficulty more, is one of difficult miscellaneous diseases of department of dermatologry, the court is in May, 2013 ~ in October, 2013 clinical position, Chinese herb decoction treatment retention of damp-heat in the interior eczema 375 example, achieve satisfied effect, existing report is as follows:
Data and method
Physical data
Collect in May, 2013 ~ in October, 2013, carry out 375 routine patients of the Chinese herb decoction treatment retention of damp-heat in the interior eczema of going to a doctor the court, wherein, man 219 example, female 156 example; 13 ~ 76 years old age, average 35.5 years old; The shortest 2d of the course of disease, the longest 12 years, skin lesion is distributed in health everywhere.
Therapeutic Method
According to skin skin lesion feature, in conjunction with patient's medical history and clinical symptoms determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, be divided into 3 type treatments.
Damp and hot and heavy
Totally 95 examples.Skin lesion is based on erythematous papules, obvious with pruritus during skin burns heat, red tongue with thin and yellow fur, floating pulse or sliding number.Be more common in eczema just originator.
Matched group: 43 examples, uses Tacrolimus paste to be coated with outward, 0.3g/ time, 2 times/day, keeps eczema place health.
Treatment group: 52 examples, traditional Chinese medicinal lotion 1 washout that side prepares by the embodiment of the present invention 1, keeps eczema place health by 2 times/day.
Thermogravimetric is in wet type
Totally 134 examples, with skin lesion flushing, scorching hot, mild swelling, pimple is in blocks or vesicle is intensive, sepage then, pruritus without stopping, companion's fever of the body, thirsty, bitter taste, fidgety, oliguria with reddish urine, constipation, red tongue, yellow and greasy fur, stringy and rolling pulse number.Common with acute eczema, morbidity is anxious, and the course of disease is short.
Matched group: 51 examples, uses Tacrolimus paste to be coated with outward, 0.3g/ time, 2 times/day, keeps eczema place health.
Treatment group: 83 examples, traditional Chinese medicinal lotion 1 washout that side prepares by the embodiment of the present invention 1, keeps eczema place health by 2 times/day.
Weight in wet base is in pattern of fever
Totally 146 examples, skin lesion has pimple or papulovesicle and phlysis with local, and flushing is not obvious, and color is filbert, oozes out many, rotten to the corn, and pruritus is acute, and touching difficulty is more disease.Accompany indigestion and loss of appetite lack of appetite, distension and fullness in the abdomen, large loose stool is thin, and lassitude is uncomfortable, and light red tongue, white and thin fur or micro-greasy, moderate pulse is unable.Be more common in nummular eczema, atoipc dermatitis.
Matched group: 56 examples, uses Tacrolimus paste to be coated with outward, 0.3g/ time, 2 times/day, keeps eczema place health.
Treatment group: 90 examples, traditional Chinese medicinal lotion 1 washout that side prepares by the embodiment of the present invention 1, keeps eczema place health by 2 times/day.
The equal medication of all prescriptions 14 days 28 days is 1 course for the treatment of.
Criterion of therapeutical effect
From plan criterion of therapeutical effect.Skin lesion all disappears or disappears more than 95% for curing; Skin lesion disappears more than 50% for taking a turn for the better; Skin lesion disappears less than 30% as invalid.
Result
Damp and hot and the patient's comparitive study of recombinating of table 1 (example, %)
Group N Cure Take a turn for the better Invalid Total effective rate %
Matched group 43 13 28 12 72.09
Treatment group 52 19 30 3 94.23
Table 2 thermogravimetric is in wet group of patient's comparitive study (example, %)
Group N Cure Take a turn for the better Invalid Total effective rate %
Matched group 51 10 32 9 82.35
Treatment group 83 19 60 4 95.18
Table 3 weight in wet base is in heat group patient comparitive study (example, %)
Group N Cure Take a turn for the better Invalid Total effective rate %
Matched group 56 13 32 11 80.36
Treatment group 90 26 58 6 93.33
Discuss
Best in pattern of fever curative effect with weight in wet base in three kinds of pattern of syndrome, therapeutic effect is best, and not easily repeatedly; Thermogravimetric is cumbersome in the treatment of wet type, and the improvement of skin lesion is cured low, and easily repeatedly, treatment group is better than matched group; Damp and hot and therapeutic effect of recombinating is also relatively good, treatment group curative effect is obviously better than matched group.
Comprehensive analysis traditional Chinese medicinal lotion of the present invention is for the therapeutic effect of the eczema of various pattern of syndrome, and traditional Chinese medicinal lotion of the present invention has good curative effect.Clinic is promoted.
Embodiment 6 experimentation
Experiment reagent
Histamine: Shanghai Inst. of Biochemistry, Chinese Academy of Sciences;
10% chloral hydrate: purchased from Concord Hospital pharmacy;
Dimethylbenzene: Beijing Fine Chemical Works;
Acetone solution: Beijing Fine Chemical Works;
She Wen is blue: Serva company of West Germany produces, Solution on Chemical Reagents in Shanghai factory subpackage;
Epidermis S. aureus L-forms stock solution: China-Japan Friendship Hospital's Bacteriology Room provides;
0.9% normal saline: Beijing Sen Yousi Pharmaceuticals Ltd;
Boric acid powder: Beijing Fine Chemical Works;
Skin bacterial flora: Beijing Hua Yangkui dragon pharmaceutical Co. Ltd produces.
Traditional Chinese medicinal lotion 1 prepared by the embodiment of the present invention 1, is concentrated into containing crude drug 0.85g/ml, then prepares wet tissue, for subsequent use.
Laboratory animal
Animal Wistar rat, Male Kunming strain mice, albino guinea-pig; There is provided by the Chinese Academy of Sciences (Jinan) Experimental Animal Center.
Experimental apparatus
Thermostat water bath: Beijing Xicheng District medical apparatus and instruments factory produces;
721 spectrophotometers: Shanghai the 3rd analytical tool factory produces;
800 type centrifuges: Shanghai Medical Apparatus and Instruments Factory produces;
WXS mono-53B microscope: Shanghai optical instrument factory;
Analytical balance F people 2104: Shanghai balance equipment factory produces.
Statistical method
All data are all applied SPSS13.0 software and are carried out statistical analysis, and experimental data adopts represent, between group, mean compares and carries out t inspection.
Traditional Chinese medicinal lotion of the present invention is on the impact of rat aorta permeability
Method
Get body weight 180-210g, Wistar male rat, 32 are divided into 4 groups at random, often organize 8; Whole rats by intraperitoneal injection 10% chloral hydrate lml anaesthetizes; With electric shaver manually by back cropping (3x3cm 2), all use normal saline, 3% borate, Skin bacterial flora (1:50), traditional Chinese medicinal lotion wet tissue soak cropping place of the present invention 1 hour respectively, and then injection histamine and 5 causes inflammation once tryptamines 0.lml respectively, at once animal is put to death after injecting she Wen blue 50mg/kg, 15min by femoral vein; Measure back mottle transverse diameter (a) and vertical footpath (b) with ruler, bring a and b into formula: by S=[(a+b)/2] 2π, calculates mottle area; Get each Mus back from mottle centre to cause scorching Pigmented Skin and be about 0.5/2.5cm 2, cutting perpendicularly skin lesion, measures skin thickness under vertical section being placed in wxs-53B microscope; Shredded by skin, the acetone mixed liquor of normal saline 5ml being placed in 7:3 soaks again, and inserts in 65 DEG C of incubators and hatch 48h, to take out in 1500r/min centrifugal 10 minutes, gets supernatant, by the optical density of 721 spectrophotometer 620nm place its filtrates of side.Finally institute's value is carried out statistical procedures.
Result
Between four groups of rats, body weight, mottle area, skin thickness, optical density compare.Four groups of mutual rat body weight ratios are P>0.05, there was no significant difference.Four groups of mutual mottle area ratio: A are respectively compared with B, C, D, and B and D compares and is P<0.01, has pole significant difference; C is P>0.05 with B, D respectively, there was no significant difference. four groups of mutual rat skin lesion Thickness Ratio A respectively compared with B, C, D, B and D compares and is P<0.01, has pole significant difference; B and C, C and D compare and are P<0.05, have significant difference.Four groups of mutual optical density ratios: A is P<0.01 respectively compared with B, C, D, has pole significant difference; B is P<0.05 respectively compared with C, D, has significant difference; C and D compares P>0.05, there was no significant difference.Illustrate that skin health group is close with Chinese medicine preparation wet tissue group of the present invention, and boric acid group is not as skin health and traditional Chinese medicinal lotion wet tissue group of the present invention, and normal saline group is the most weak in reduction rat aorta permeability.In table 4.
Table 4: four groups of medicines are to the comparison of rat aorta permeability effect
Group Body weight g Skin thickness mm Mottle area cm 2 Optical density
Control group A 213.0±10.5 2.12±0.05 3.35±0.55 0.65±0.06
Boric acid group B 221.9±8.5 2.10±0.02 3.02±0.08 0.54±0.05
Skin health group C 220.3±6.58 2.04±0.08 2.95±0.14 0.48±0.06
Wet tissue group D 213.8±7.32 1.95±0.07 2.85±0.17 0.43±0.12
Traditional Chinese medicinal lotion Anti-inflammatory Mechanism research of the present invention
Method
Get body weight 25-30g, Male Kunming strain mice 40, be divided into 4 groups at random, often organize 10, normal saline, 3% borate, Skin bacterial flora (l:50), traditional Chinese medicinal lotion wet tissue of the present invention is smeared respectively at every mouse right ear wide place cotton balls, 10 minutes once, continuous 6 times, amounts to 1 hour; Then 100% dimethylbenzene 20 section 1 is applied to two sides before and after each mouse right ear, respectively at cause scorching after 0.5h l.5h 2.5h repaste and smear 3 above-mentioned four kinds of medicinal liquids, left ear normal saline concurrent control; Cause scorching latter 4 hours by animal sacrificed by decapitation, cut two ears along auricle baseline, two ear 6llun diameter puncheres are laid auricle and weighs, the difference of every Mus two auricle weight is swelling.
Result
Four groups of mutual Mouse Weight ratios are P>0.05, there was no significant difference.Four groups of mutual left ear heavy phase ratios are P>0.05, there was no significant difference.Four groups of mutual auris dextra weights: A and B and C and D compare respectively and be P>0.05, there was no significant difference; A and C, D and B and C compare respectively and are P<0.05, have significant difference; B and D compares P<0.01, has pole significant difference.Four groups of mutual mice interaural difference value (swelling) ratios: A and B, C, D and D and B, C compare respectively and be P<0.01, have pole significant difference; B and c compares P<0.05, has significant difference.Illustrate that Chinese medicine preparation wet tissue of the present invention is the strongest in antiinflammatory action, skin health group is better than boric acid group, and NS is the most weak.In table 5.
The comparable group of table 5 four kinds of medicine antiinflammatory actions
The research of Chinese medicine preparation itching-relieving action mechanism of the present invention
Method
4 groups are divided at random by body weight 310-350g albino guinea-pig, often organize 8, respectively at right back instep cropping position soak (adhesive tape is fixed) normal saline of each Cavia porcellus, 3% borate, Skin bacterial flora (1:50) and traditional Chinese medicinal lotion wet tissue of the present invention, 10 minutes liquid feedings once, continuous 6 times, amount to 1 hour; The histamine phosphate 50 μ l/ pawl of 0.01% is dripped at each position, drip at same position the histamine phosphate that increasing concen-trations is 0.02%, 0.03%, 0.04% equivalent every 3min more later, till there is licking foot in Cavia porcellus, with give in this period each animal the total amount of histamine phosphate of dripping cut off from for causing to itch.And the itch-threshold often organizing interior each animal is carried out statistical analysis.
Result
Four groups of mutual Cavia porcellus weight ratios are P>0.05, there was no significant difference.Four groups of mutual Cavia porcellus histamine phosphate amount ratios: A and C, D, B and C, D, C and D compares respectively and is P<0.01, has pole significant difference; A and B is in a ratio of P<0.05, has significant difference.Illustrate that Chinese medicine preparation wet tissue of the present invention and skin health group itching-relieving action are better than matched group and boric acid group, and Chinese medicine preparation wet tissue group of the present invention is better than skin health group, boric acid group is better than matched group.In table 6.
Relatively grinding of table 6 four kinds of medicine itching-relieving actions
Group Body weight g Skin thickness mm
Control group A 313.0±6.89 0.15±0.35
Boric acid group B 321.9±8.65 0.19±0.22
Skin health group C 328.3±7.38 0.26±0.38
Wet tissue group D 323.8±5.52 0.34±0.47
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (6)

1. treat a traditional Chinese medicinal lotion for retention of damp-heat in the interior type eczema, it is characterized in that: crude drug comprises Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Herba Schizonepetae, Alumen, Radix Sophorae Flavescentis, Fel Ursi, Cornu Naemorhedi, Flos Lonicerae, Fructus Forsythiae, Radix Trichosanthis, Radix Et Rhizoma Rhei, Galla Chinensis, Radix Glycyrrhizae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Radix Sangusorbae, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, the Fructus Kochiae, Fructus Tribuli, Semen Persicae, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi.
2. the traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema as claimed in claim 1, is characterized in that: the weight portion of each crude drug is respectively Radix Scutellariae 25 weight portion ~ 40 weight portion, Rhizoma Coptidis 30 weight portion ~ 40 weight portion, Cortex Phellodendri 40 weight portion ~ 55 weight portion, Herba Schizonepetae 20 weight portion ~ 35 weight portion, Alumen 10 weight portion ~ 15 weight portion, Radix Sophorae Flavescentis 20 weight portion ~ 40 weight portion, Fel Ursi 15 weight portion ~ 20 weight portion, Cornu Naemorhedi 10 weight portion ~ 15 weight portion, Flos Lonicerae 25 weight portion ~ 40 weight portion, Fructus Forsythiae 15 weight portion ~ 25 weight portion, Radix Trichosanthis 10 weight portion ~ 15 weight portion, Radix Et Rhizoma Rhei 20 weight portion ~ 30 weight portion, Galla Chinensis 15 weight portion ~ 25 weight portion, Radix Glycyrrhizae 20 weight portion ~ 30 weight portion, Fructus Cnidii 15 weight portion ~ 20 weight portion, Rhizoma Smilacis Glabrae 25 weight portion ~ 35 weight portion, Radix Sangusorbae 20 weight portion ~ 25 weight portion, Herba Portulacae 25 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 20 weight portion ~ 30 weight portion, Rhizoma Osmundae 15 weight portion ~ 20 weight portion, Radix Cynanchi Paniculati 15 weight portion ~ 25 weight portion, the Radix Angelicae Dahuricae 15 weight portion ~ 25 weight portion, Cortex Magnoliae Officinalis 10 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 15 weight portion ~ 30 weight portion, Rhizoma Atractylodis 15 weight portion ~ 25 weight portion, the Radix Aucklandiae 15 weight portion ~ 20 weight portion, Rhizoma Arisaematis 10 weight portion ~ 15 weight portion, the Fructus Kochiae 15 weight portion ~ 25 weight portion, Fructus Tribuli 10 weight portion ~ 15 weight portion, Semen Persicae 15 weight portion ~ 25 weight portion, Radix Rehmanniae 25 weight portion ~ 35 weight portion, Cortex Moutan 15 weight portion ~ 25 weight portion, Pheretima 10 weight portion ~ 15 weight portion, Semen Coicis 25 weight portion ~ 35 weight portion and Caulis Spatholobi 25 weight portion ~ 40 weight portion.
3. the traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema as claimed in claim 1 or 2, is characterized in that: the weight portion of each crude drug is respectively Radix Scutellariae 30 weight portion ~ 35 weight portion, Rhizoma Coptidis 35 weight portion ~ 40 weight portion, Cortex Phellodendri 45 weight portion ~ 50 weight portion, Herba Schizonepetae 25 weight portion ~ 30 weight portion, Alumen 10 weight portion ~ 15 weight portion, Radix Sophorae Flavescentis 30 weight portion ~ 35 weight portion, Fel Ursi 15 weight portion ~ 20 weight portion, Cornu Naemorhedi 10 weight portion ~ 15 weight portion, Flos Lonicerae 30 weight portion ~ 35 weight portion, Fructus Forsythiae 20 weight portion ~ 25 weight portion, Radix Trichosanthis 10 weight portion ~ 15 weight portion, Radix Et Rhizoma Rhei 25 weight portion ~ 30 weight portion, Galla Chinensis 15 weight portion ~ 20 weight portion, Radix Glycyrrhizae 25 weight portion ~ 30 weight portion, Fructus Cnidii 15 weight portion ~ 20 weight portion, Rhizoma Smilacis Glabrae 30 weight portion ~ 35 weight portion, Radix Sangusorbae 20 weight portion ~ 25 weight portion, Herba Portulacae 30 weight portion ~ 35 weight portion, Radix Paeoniae Rubra 25 weight portion ~ 30 weight portion, Rhizoma Osmundae 15 weight portion ~ 20 weight portion, Radix Cynanchi Paniculati 20 weight portion ~ 25 weight portion, the Radix Angelicae Dahuricae 15 weight portion ~ 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 20 weight portion ~ 25 weight portion, Rhizoma Atractylodis 15 weight portion ~ 20 weight portion, the Radix Aucklandiae 15 weight portion ~ 20 weight portion, Rhizoma Arisaematis 10 weight portion ~ 15 weight portion, the Fructus Kochiae 20 weight portion ~ 25 weight portion, Fructus Tribuli 10 weight portion ~ 15 weight portion, Semen Persicae 20 weight portion ~ 25 weight portion, Radix Rehmanniae 30 weight portion ~ 35 weight portion, Cortex Moutan 15 weight portion ~ 20 weight portion, Pheretima 10 weight portion ~ 15 weight portion, Semen Coicis 30 weight portion ~ 35 weight portion and Caulis Spatholobi 30 weight portion ~ 35 weight portion.
4. the traditional Chinese medicinal lotion of the treatment retention of damp-heat in the interior type eczema as described in claims 1 to 3, is characterized in that: the weight portion of each crude drug is respectively Radix Scutellariae 35 weight portion, Rhizoma Coptidis 35 weight portion, Cortex Phellodendri 50 weight portion, Herba Schizonepetae 30 weight portion, Alumen 10 weight portion, Radix Sophorae Flavescentis 30 weight portion, Fel Ursi 20 weight portion, Cornu Naemorhedi 10 weight portion, Flos Lonicerae 35 weight portion, Fructus Forsythiae 20 weight portion, Radix Trichosanthis 10 weight portion, Radix Et Rhizoma Rhei 25 weight portion, Galla Chinensis 20 weight portion, Radix Glycyrrhizae 25 weight portion, Fructus Cnidii 15 weight portion, Rhizoma Smilacis Glabrae 30 weight portion, Radix Sangusorbae 20 weight portion, Herba Portulacae 30 weight portion, Radix Paeoniae Rubra 25 weight portion, Rhizoma Osmundae 15 weight portion, Radix Cynanchi Paniculati 20 weight portion, the Radix Angelicae Dahuricae 20 weight portion, Cortex Magnoliae Officinalis 15 weight portion, Pericarpium Citri Reticulatae 20 weight portion, Rhizoma Atractylodis 20 weight portion, the Radix Aucklandiae 15 weight portion, Rhizoma Arisaematis 10 weight portion, the Fructus Kochiae 20 weight portion, Fructus Tribuli 10 weight portion, Semen Persicae 20 weight portion, Radix Rehmanniae 30 weight portion, Cortex Moutan 20 weight portion, Pheretima 10 weight portion, Semen Coicis 30 weight portion and Caulis Spatholobi 30 weight portion.
5. the preparation method of traditional Chinese medicinal lotion described in Claims 1-4, is characterized in that, comprising:
The first step, Herba Schizonepetae, Galla Chinensis, Fructus Cnidii, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, Fructus Tribuli, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi are mixed by weight, use water vapour distillation volatile oil, the another device of the aqueous solution after distillation is collected;
Second step, all the other crude drug components are mixed with the medicinal residues after above-mentioned distillating extracting oil by weight, decoct with water extraction secondary, first time adds this volume of mixture sum 8 times amount soak by water 2 hours, second time adds this volume of mixture sum 5 times amount soak by water 1 hour, collecting decoction, filter, filtrate 60 DEG C is concentrated into the concentrated solution that relative density is 1.10 ~ 1.15, let cool, adding determining alcohol is that the ethanol of 80% is to reaching 70% containing ethanol contend amount, stir evenly, 2 ~ 5 DEG C of standing cold preservation 24 hours, filter, it is 1.14 ~ 1.20 that filtrate recycling ethanol 60 DEG C are concentrated into relative density, add the water dilution of equal volume amounts, stir evenly, 2 ~ 5 DEG C leave standstill cold preservation 24 hours again, filter,
3rd step, the concentrated solution first step being obtained the aqueous solution after distillation obtained with second step mixes, and stirs; And adjust ph to 5.0 ~ 6.0, add water and be adjusted to 1000ml, filter, sterilizing, to obtain final product.
6. the preparation method of the traditional Chinese medicinal lotion for the treatment of retention of damp-heat in the interior type eczema as claimed in claim 5, it is characterized in that: the described first step is specially further and Herba Schizonepetae, Galla Chinensis, Fructus Cnidii, Herba Portulacae, Radix Paeoniae Rubra, Rhizoma Osmundae, Rhizoma Atractylodis, the Radix Aucklandiae, Rhizoma Arisaematis, Fructus Tribuli, Radix Rehmanniae, Cortex Moutan, Pheretima, Semen Coicis and Caulis Spatholobi is mixed by weight, first soak 20min ~ 40min, pour in volatile oil extractor, the way of distillation extracts volatile oil 4 ~ 6h, amount of water is 8-15 times of the mixture weight that this step obtains, and obtains volatile oil.
CN201610059970.8A 2016-01-28 2016-01-28 Traditional Chinese medicine skin-wash liquid for treating hot and damp eczema Pending CN105535715A (en)

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CN106038835A (en) * 2016-06-28 2016-10-26 农雪梅 Plant external-use lotion for treating eczema and preparation method thereof
CN106177703A (en) * 2016-07-29 2016-12-07 安徽新盛中药饮片有限公司 A kind of external application Chinese medicine treating eczema
CN106691950A (en) * 2017-02-27 2017-05-24 陕西理工学院 Selfheal-containing Chinese herbal hand sanitizer and preparation method
CN106859962A (en) * 2017-01-23 2017-06-20 安徽绿莹彩龙艾绒制药有限公司 A kind of medicine moxa-moxibustion of moxibustion bite by mosquitos
CN107260864A (en) * 2017-08-15 2017-10-20 习水县格林生态农业科技有限公司 A kind of bath lotion of Chinese medicinal herbs for increasing pig immunity and preparation method thereof
CN108159198A (en) * 2018-03-21 2018-06-15 亳州市君臣佐使药业有限公司 A kind of skin eczema external preparation and preparation method thereof
CN109453336A (en) * 2018-10-16 2019-03-12 吴蓓莉 It is a kind of for treating the Chinese medicine composition of wet disease
CN111067987A (en) * 2019-12-24 2020-04-28 潘广健 Sweating method formula for regulating damp-heat constitution and using method
CN114569673A (en) * 2022-04-24 2022-06-03 李宗霞 Traditional Chinese medicine preparation for treating skin scald scars
CN117229862A (en) * 2023-09-18 2023-12-15 广州桦欣塑胶制品有限公司 Perfumed soap with mite-removing and bacteria-inhibiting effects and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN106038835A (en) * 2016-06-28 2016-10-26 农雪梅 Plant external-use lotion for treating eczema and preparation method thereof
CN106177703A (en) * 2016-07-29 2016-12-07 安徽新盛中药饮片有限公司 A kind of external application Chinese medicine treating eczema
CN106859962A (en) * 2017-01-23 2017-06-20 安徽绿莹彩龙艾绒制药有限公司 A kind of medicine moxa-moxibustion of moxibustion bite by mosquitos
CN106691950A (en) * 2017-02-27 2017-05-24 陕西理工学院 Selfheal-containing Chinese herbal hand sanitizer and preparation method
CN107260864A (en) * 2017-08-15 2017-10-20 习水县格林生态农业科技有限公司 A kind of bath lotion of Chinese medicinal herbs for increasing pig immunity and preparation method thereof
CN108159198A (en) * 2018-03-21 2018-06-15 亳州市君臣佐使药业有限公司 A kind of skin eczema external preparation and preparation method thereof
CN109453336A (en) * 2018-10-16 2019-03-12 吴蓓莉 It is a kind of for treating the Chinese medicine composition of wet disease
CN111067987A (en) * 2019-12-24 2020-04-28 潘广健 Sweating method formula for regulating damp-heat constitution and using method
CN114569673A (en) * 2022-04-24 2022-06-03 李宗霞 Traditional Chinese medicine preparation for treating skin scald scars
CN114569673B (en) * 2022-04-24 2024-04-23 李宗霞 Traditional Chinese medicine preparation for treating skin scald and scar
CN117229862A (en) * 2023-09-18 2023-12-15 广州桦欣塑胶制品有限公司 Perfumed soap with mite-removing and bacteria-inhibiting effects and preparation method thereof

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