CN102205026B

CN102205026B - Chinese medicinal composition for treating children chronic sinusitis and preparation method thereof

Info

Publication number: CN102205026B
Application number: CN 201110139094
Authority: CN
Inventors: 鹿岩; 李佃场; 魏志刚
Original assignee: Individual
Current assignee: XI'AN BOAI PHARMACEUTICAL CO Ltd
Priority date: 2011-05-27
Filing date: 2011-05-27
Publication date: 2013-03-27
Anticipated expiration: 2031-05-27
Also published as: CN102205026A

Abstract

The invention discloses a Chinese medicinal composition for treating children chronic sinusitis. The oral taken medicine comprises the following active ingredients in part by weight: 10 to 20 parts of Chinese angelica, 10 to 20 parts of xanthium sibiricum, 10 to 20 parts of nutgrass galingale rhizome, 10 to 20 parts of weeping forsythia, 10 to 20 parts of wax gourd seed, 10 to 20 parts of Szechuan lovage rhizome, 10 to 20 parts of platycodon root, 10 to 20 parts of sargent gloryvine, 10 to 20 parts of heartleaf houttuynia herb, 10 to 20 parts of astragalus, 10 to 20 parts of biond magnolia flower, 10 to 20 parts of angelica dahurica, 10 to 20 parts of baical skullcap root, 10 to 20 parts of Mongolian dandelion herb, 10 to 20 parts of honeysuckle and 10 to 20 parts of fineleaf schizonepetaherb; the external application medicine comprises the following active ingredients in part by weight: 10 to 20 parts of honeysuckle, 10 to 20 parts of nutgrass galingale rhizome, 10 to 20 parts of borneol, 10 to 20 parts of mint, 10 to 20 parts of manchurian wildginger, 10 to 20 parts of chrysanthemum, 10 to 20 parts of safflower, 10 to 20 parts of bletilla striata, 10 to 20 parts of divaricate saposhnikovia root and 10 to 20 parts of frankincense. The Chinese medicinal composition makes a nasal part lesion subjected to benign simulation so as to clear the meridians, dispel blood block, accelerate blood smoothness and achieve an effect of strengthening body resistance and eliminating evil, and has a better clinical effect through combined treatment of oral administration and external application.

Description

A kind of Chinese medicine composition for the treatment of children chronic sinusitis and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly a kind of Chinese medicine preparation for the treatment of children chronic sinusitis and preparation method thereof.

Background technology

Chronic sinusitis is the hals,Nasen und Ohrenheilkunde commonly encountered diseases, and infecting the mucosa edema that causes with allergy is the main cause that sinusitis occurs, and secondly is that infant is vulnerable. immunity is poor.Because the symptom of children chronic sinusitis is except sniffle such as pus tears, nasal obstruction, postnasal drip, nose bleeding, often with adjacent organs symptom and whole body and Secondary Symptom, so usually at first go to a doctor in other section office.So that cause mistaken diagnosis or treat lack of standardizationly, form at last chronic sinusitis, because the chronic sinusitis symptom is lighter or asymptomatic, often easily out in the cold.Modern medicine is thought its pathogenic factor: (1) acute rhinitis is repeatedly shown effect and is failed in time treatment; (2) infect and loose paraphyte causes nasal obstruction, hinder the Mucociliary transport of nose and nasal sinuses; (3) allergy causes that the edema of nasal cavity and nasal sinuses hinders drain; (4) sinunasal mucosa dysfunction.At present, for the treatment of chronic sinusitis still with focal cleaning, unimpeded drain, infection, restore funcitons.Traditional nasal sinus opening, radical correction and in recent years extensively carry out functional nasal sinus opening under the intranasal mirror, drainage, be aided with art before, the infection of postoperative, suppress allergy, obtained than promising result, but this type of operation only is suitable for the adult mostly, the child is difficult to accept usually, especially child below 12 years old, almost can only take expectant treatment and as negative pressure displacement art, the maxillary sinus puncture of auxiliary treatment, be difficult for accepted more, and curative effect is also uncertain, infant is many can not adhere to systematic treating, has a strong impact on curative effect.And functional sinusitis is performed the operation because operation and the cleaning of postoperative oral cavity are all painful, and the sick child can not cooperate and affect the treatment, and causes sick child's chronic sinusitis to become clinical refractory disease.

Sinusitis is otorhinolaryngologic commonly encountered diseases, frequently-occurring disease.Each phylogeny imperfection of child, system of defense is weak, and the sickness rate of flu, respiratory tract infection and various infectious disease all is higher than the adult.And child's nasal sinuses is not yet physically well developed, and sinus mucosa is mutually continuous with bronchia mucosal, and Dou Kou is relatively roomy, and acute rhinitis is often involved nasal sinuses; Nasal mucosa is tender, is rich in blood vessel, and mucosa swelling makes Dou Kou block inadequate drainage during infection, so the sickness rate of sinusitis in children is higher.

Sinusitis belongs to Chinese medicine nasal sinusitis category.How because of wind-heat evil toxin coagulation nose key; Or accumulate in the pathogenic heat, evil poison follows through upper steaming; Or liver and gall lose in catharsis, and the gallbladder fire follows through upper criminal and injures the nose key, all can burn bright QI and blood, turn to that pus is turbid to be formed.Control suitable heat-clearing and toxic substances removing, the removing blood stasis evacuation of pus. modern medicine thinks that chronic sinusitis is the coefficient result of many factors, comprise that general immunity power is low, the body allergy increases the factors such as local pathogenic infection and hole mouth sinotunnel c omplex deformity, microcirculation disturbance.The patients with chronic sinusitis hypoimmunity in case flu is suffered from cold, causes the congested swelling of nasal mucosa, just can cause sinusitis.The primary disease course of disease is longer, and easily repeatedly outbreak is difficult for thoroughly radical cure, often brings worried and painful to the patient.There is no at present both at home and abroad desirable medicine conventional therapy effects such as (not good enough) anti-inflammations and method except nasal endoscopic surgery, especially Control in recurring is more difficult.

Chronic sinusitis belongs to Chinese medicine " nasal sinusitis " category, how because of the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure.Obstinate, impairment of purifying function of the lung, phlegm-damp is stopped at lung, and the lung meridian stagnated fire is due to the knot nose key that stagnates, the nasal sinuses sarolemma of burning.At dirty genus lung, also there is certain relation sick position with taste at nose." Ling Shu Miraculous Pivot or Divine Axis vessles length ": " lung-QI connecting with the nose, lung and then can know good and foul smells ".Chronic sinusitis is except due to acute sinusitis continues development, and also promising healthy energy is weak can not win due to the heresy." well-known doctor's essay ": " the nasal obstruction anosmia, or but meet cold month many plugs, or the just plug that takes a little cold, the not clear person of reporting, common customs are all thought lung cold, and with the hot using warming therapy medicine of the tonneau that induces sweat, do not imitate.Hardly realize that this is that lung meridian have pathogenic fire " its pathogenesis is deficiency in origin and excess in superficiality or simulataneous insufficiency and excessive.So the Therapeutic Principle should be strengthening vital QI to eliminate pathogenic factors, stuffy nose relieving is had one's ideas straightened out, heat-clearing and toxic substances removing.

The in recent years extensive use of CT has been played vital effect to the Diagnosing children chronic sinusitis, but because patient age is less than normal, chronic sinusitis treatment time is grown (more than antibiotic 4 W, local glucocorticoid 3～6 months is more than mucus eccritic 4 w).And as negative pressure displacement art, the maxillary sinus puncture of auxiliary treatment, be difficult for accepted more, and curative effect and uncertain, and infant is many can not adhere to systematic treating, has a strong impact on curative effect.And functional sinusitis is performed the operation because operation and the cleaning of postoperative oral cavity are all painful, and the sick child can not cooperate and affect the treatment, and causes sick child's chronic sinusitis to become clinical refractory disease.Clinically can effectively change the new drug that the sick child resists Chinese medicine odor in the urgent need to a kind of not only Chinese medicine composition simply but also targetedly, it is painful to alleviate the sick child.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of prescription is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to make, and is with low cost, and abnormal smells from the patient does not affect the infant mouthfeel and causes the new drug that infant is resisted.The present invention makes the nose focus be subject to optimal stimulation, and dredging the meridian is eliminated the QI and blood retardance, promotes unblocked blood flowing, reaches the strengthening vital QI to eliminate pathogenic factors effect, combination of inner and outside treatment, and clinical efficacy is excellent.The present invention adopts the Chinese crude drug of different properties, has carried out the science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, is difficult for recurrence after curing.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of children chronic sinusitis, be comprised of endo-medicine and external used medicine, the ratio of weight and number of various crude drug is in the described endo-medicine: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Herba Xanthiis, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Semen Benincasaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Platycodoniss, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts of Herba Houttuyniae, 10～20 parts of the Radixs Astragali, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Schizonepetae;

The ratio of weight and number of various crude drug is in the described external used medicine: 10～20 parts of Flos Loniceraes, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Borneolum Syntheticums, 10～20 parts of Herba Menthaes, 10～20 parts of Herba Asaris, 10～20 parts of Flos Chrysanthemis; 10～20 parts on Flos Carthami, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Olibanums.

The Chinese medicine composition of described treatment children chronic sinusitis, the ratio of weight and number of various crude drug can also be 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Herba Xanthiis in the endo-medicine, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Semen Benincasaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Platycodoniss, 10～20 parts of Caulis Sargentodoxaes, 10～15 parts of Herba Houttuyniae, 10～15 parts of the Radixs Astragali, 10～15 parts of Flos Magnoliaes, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Scutellariaes, 10～15 parts of Herba Taraxacis, 10～15 parts of Flos Loniceraes, 10～15 parts of Herba Schizonepetae;

The ratio of weight and number of various crude drug can also be 10～15 parts of Flos Loniceraes, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Borneolum Syntheticums, 10～15 parts of Herba Menthaes, 10～15 parts of Herba Asaris, 10～20 parts of Flos Chrysanthemis in the described external used medicine; 10～20 parts on Flos Carthami, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Olibanums.

The Chinese medicine composition of described treatment children chronic sinusitis, the ratio of weight and number of various crude drug also can be 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Herba Xanthiis in the endo-medicine, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Semen Benincasaes, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Platycodoniss, 10～15 parts of Caulis Sargentodoxaes, 10～20 parts of Herba Houttuyniae, 10～20 parts of the Radixs Astragali, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Schizonepetae;

The ratio of weight and number of various crude drug also can be 10～20 parts of Flos Loniceraes, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Borneolum Syntheticums, 10～20 parts of Herba Menthaes, 10～20 parts of Herba Asaris, 10～15 parts of Flos Chrysanthemis in the described external used medicine; 10～20 parts on Flos Carthami, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Olibanums.

For solving the problems of the technologies described above, the invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of children chronic sinusitis, the dosage form of described oral preparations comprises for the preparation method of honey refining pill:

A, first Herba Xanthii, Rhizoma Cyperi, Flos Lonicerae distillation are crystallized into powder;

B, get the surplus stock medicine again and put into soak with ethanol, heat is extracted 2 times, becomes the extractum shape, is component 1;

C, medicinal residues extracting in water 1 time, thickening filtration are the extractum shape, are component 2;

D, above-mentioned two kinds of extractum are condensed into pasty state, add the powder that a step obtains, add Mel and be twisted into pill.

Among the described step b, can get crude drug and add 60-90% soak with ethanol 1-2 hour that 5-10 doubly measures, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, the 80-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, extracts active ingredient, concentrated solution is settled into the extractum shape, mass continues heating and is concentrated into the extractum shape, and stand for standby use becomes component 1; Among the described step c, medicinal residues add 5-10 times of water gaging and soaked 1-2 hour, extract 1 time in 1-1.5 hour, as component 2.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of children chronic sinusitis, and the preparation process that described endo-medicine dosage form is capsule comprises:

A, all crude drug are put into the ethanol heating and refluxing extraction;

B, again with medicinal residues water heating and refluxing extraction;

C, above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and concentrated sucking filtration absorption get medicated powder.

Among the described step a, raw medicinal material can be put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; Among the described step b, the medicinal residues that refined can be put into 10 times of water gagings, heating and refluxing extraction 3 times each 45 minutes～1 hour, merges filtering and standing with 3 extracting solution.

Among the described step c, above-mentioned two kinds of filtrates can be merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL is behind the sucking filtration, when the relative density of filtrate is about 20 ℃ 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, uses first deionized water or the distilled water eluting of 10 times of resin column volumes, uses 95% ethanol elution of 5 times of resin column volumes again, collects ethanol elution, removes solvent, obtains raw material medicated powder and incapsulates.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of the Chinese medicine preparation of children chronic sinusitis again, and the preparation process that described external used medicine dosage form is drop is: first all crude drug are just distilled with steam method, obtain crystal; Then distillation test residue is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing, remove supernatant; The crystal of distillation extraction is put into filtrate, soak 5-10 days available; Can directly splash into nasal cavity 2-5 during use and drip, face upward head and allow medicinal liquid nasal cavity profit reduction and reserving 5-10 minute, perhaps after medicinal liquid soaks, fill in nasal cavity 10-20 minute with the Cotton Gossypii of sterilizing.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of the Chinese medicine preparation of children chronic sinusitis, the endo-medicine dosage form can for: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, pin powder or slow releasing capsule; The external used medicine dosage form can be drop, spray, ointment, tincture, irrigation or absorbent cotton suppository.

The present invention fills a prescription simply, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to make, and is with low cost, and abnormal smells from the patient does not affect the infant mouthfeel and causes the infant resistance.The present invention makes the nose focus be subject to optimal stimulation, and dredging the meridian is eliminated the QI and blood retardance, promotes unblocked blood flowing, reaches the strengthening vital QI to eliminate pathogenic factors effect, combination of inner and outside treatment, and clinical efficacy is excellent.The present invention adopts the Chinese crude drug of different properties, has carried out the science compatibility, can reach desirable therapeutic effect, and safety, and toxic and side effects is little, and preparation is simple, the focus of going directly, and healing time is short, is difficult for recurrence after curing.

The specific embodiment

" Plain Questions gas fault opinion " day: " the gallbladder transferring pathogenic heat to the brain, then hot volume nasal sinusitis.The nasal sinusitis person, rhinorrhea with turbid discharge also." gallbladder-heat follows through moving in brain, body fluid steams turbid and the nasal sinuses of making a bet.The surfeit suffering is sweet, damp and hot interior life, stasis taste, upper steaming nose key.Affection due to external wind and heat, the successor crows dirty, and lung meridian is hot and suffocating, and vehement nasal sinuses burns.Chronic sinusitis belongs to the nasal sinusitis category of motherland's medical science, how to be invaded by exopathogen, and malpractice, remaining heresy is unclear, or internal organs are deficient, and sense is evil repeatedly, and evil poison is detained the hole key, and addle sarolemma or qi and blood stagnation form.Modern medicine is thought its pathogenic factor: (1) acute rhinitis is repeatedly shown effect and is failed in time treatment; (2) infect and loose paraphyte causes nasal obstruction, hinder the Mucociliary transport of nose and nasal sinuses; (3) allergy causes that the edema of nasal cavity and nasal sinuses hinders drain; (4) sinunasal mucosa dysfunction.At present, for the treatment of chronic sinusitis still with focal cleaning, unimpeded drain, infection, restore funcitons.Traditional nasal sinus opening, radical correction and in recent years extensively carry out functional nasal sinus opening under the intranasal mirror, drainage, be aided with art before, the infection of postoperative, suppress allergy, obtained than promising result, but this type of operation only is suitable for the adult mostly, the child is difficult to accept usually, especially child below 12 years old almost can only take expectant treatment.According to observations, course of disease weak point person effect is better, and cure rate is higher, and the short-term relapse rate is also lower, so primary disease should be advocated early prevention, diagnosis morning, early treatment, in order to avoid delay is difficult.Chronic sinusitis, the traditional Chinese medical science are called " nasal sinusitis ", " sinusitis with purulent discharge ".Clinical obstructed to have a stuffy nose, anosmia, nose rhinorrhea or stench, the neck distending pain, prolonged more than, hypomnesis etc. are cardinal symptom.The primary disease four seasons all can fall ill, and because its course of disease is long, normal delay is difficult, treats rather thorny.

This disease is occupied larger proportion in teenager, the confused pain of Chang Yintou and affect study and intelligence development endangers greatlyr, should cause doctor and the head of a family's great attention.In addition, during treating and control maintenance should note anti-ly catch a cold, drenching with rain, be exposed to the sun, pay attention to nasal cavity hygienic, every day is at least with clean water or warm water's nasal cavity cleaning 1 time, eats less that Rhizoma Zingiberis Recens is peppery waits hot dry thing, to the recovery of primary disease and prevent from recurring certain help is arranged.

Main component in the side is Flos Magnoliae, Herba Xanthii, the Radix Angelicae Dahuricae, Herba Menthae, Radix Scutellariae etc.Flos Magnoliae, the Radix Angelicae Dahuricae are dredged clearing the nasal passage, heat-clearing and toxic substances removing, the dispelling wind removing damp and stopping pain, and the detumescence and apocenosis granulation promoting has astriction and can improve the absorption of local blood circulation promotion secretions; Fructus Xanthii dampness, spleen invigorating lung qi dispersing are sensible, and the detoxifcation pain relieving has inhibitory action to multiple fungus, has the antiallergic effect; Fructus Forsythiae have induce sweat, cold expelling, relieving asthma, the diuresis effect, blood vessel is had contraction, be used for tunica mucosa nasi swelling; Radix Scutellariae is cleared up part of the body cavity above the diaphragm housing the heart and lungs lung-heat, removing dampness heat clearing away, hemostasis and pain-relieving, and both anti-inflammation had again anti-allergic effects; Herba Menthae has dispelling wind heat, the function of dispeling the wind, and can promote the nasal mucosa secretion and removes mucus on the mucosa, has the anti-inflammatory analgetic effect.Other several flavors all have antibacterial, strengthen immunization.Complete square conception is to dispel absurd creature, and is clear, loose, logical, foster, and attack and just do not hinder, giving consideration to both the incidental and fundamental, medication is gentle, keeps away its bitter cold and hot loose too many, is convenient to clothes of a specified duration.Primary disease often brings out because of diseases caused by exogenous pathogenic factor or increases the weight of, and can suitably add flavor according to the difference of wind and cold or wind heat, and sick for a long time body void can add flavor according to the difference of insufficiency of lung-QI and deficiency of the kidney.The primary disease cure rate improves gradually along with the prolongation for the treatment of time, and to general property, chronic ten several years and did paracentesis or the patient of operation can reach the healing purpose equally.

Herba Xanthii cures mainly flu; Wind syndrome of head; Dizzy; Nasal sinusitis, conjunctival congestion, corneal nebula, pathogenic wind-warm arthralgia pain, contracture numbness, wind leprosy, furuncle, scabies, skin pruritus, hemorrhoid, dysentery, wind and heat eliminating, the detoxifcation parasite killing.The arthralgia chiefly caused by damp pathogen contracture, loose wind dehumidifying, understand things pain-stopping.Be used for nasosinusitis headache, headche due to wind-cold.Gentle the dredging of this product reaches, the acrid in the mouth wind that falls apart, bitter dampness is turbid, understand things pain-stopping, with control nasosinusitis headache, anosmia, the time flow turbid tears, Chang Peiwu Flos Magnoliae, the Radix Angelicae Dahuricae, the same usefulness of Herba Menthae, i.e. Fructus Xanthii powder.With controlling affection of exogenous wind-cold, aversion to cold is lossless, headache nasal obstruction person, can be equal to usefulness with Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici.Tang Materia Medica: " main strong wind, epilepsy, wind syndrome of head, arthralgia chiefly caused by damp pathogen, poison is at bone marrow, and except all poison are stung, infantile malnutrition is wet extremely hides pathogenic wind toxic in the main waist knee joint.Yi Zhu Rabid-dog Canis familiaris L. poison."

The Rhizoma Cyperi resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast.Antipyretic effect: the reports such as Deng Suzhen, give mouse subcutaneous injection 20% cyperol extract, can obviously improve the threshold of pain of mice.Liu Guoqing etc. measure the threshold of pain with hot plate method, and to mouse peritoneal injection Rhizoma Cyperi volatile oil 0.1ml/kg, 10mg/kg compares with lumbar injection salt morphine, respectively at the threshold of pain of measuring each Mus after the administration in 15,30,60 and 90 minutes.The result shows that Rhizoma Cyperi volatile oil is without obvious analgesic activity.Gupta MB report, the analgesic effect that contained triterpenoid compound (IV one B) 5mg/kg gavages in the cyperol extract is suitable with the 30mg/kg aspirin.The cyperol extract has refrigeration function to the microbial rat fever of injection yeast, and it is tired and is about 6 times of sodium salicylate, and its analgesic effective ingredient also is triterpenoid compound.

Semen Benincasae is sweet, and lung is returned in cold; Large intestine channel.Function cures mainly: removing heat from the lung and dissipating phlegm; The eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; The intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria " Bencao Jingshu ": the Pi that wakes up can whet the appetite." book on Chinese herbal medicine is stated ": cure mainly heart channel intrinsic heat, little water drenches pain, and nasal surface schlempe such as numb bean, pain, and yellow fluid goes out." Bencao Congxin ": tonifying liver makes eye bright." book on Chinese herbal medicine is stated hook unit ": knot is poly-in the main abdomen, stops up in the ulceration pus and blood, all the intestines and stomach, the most key medicine.

Caulis Sargentodoxae is the dry rattan of plants of Lardizabalaceae Caulis Sargentodoxae.Has heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide.Be applicable to stomachache, traumatic injury, dysmenorrhea, the diseases such as Fengshi Guanjie pain.Caulis Sargentodoxae is good at the heat-clearing and toxic substances removing eliminating stagnation, and for controlling the key medicine of acute appendicitis, normal and Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, Herba Taraxaci or Flos Lonicerae, Fructus Forsythiae, Cortex Moutan, Semen Coicis are equal to usefulness; Control acute mastitis and swell and ache, can be equal to usefulness with Herba Taraxaci, Radix Trichosanthis, Bulbus Fritillariae Uninbracteatae, Flos Lonicerae, Fructus Forsythiae, Spica Prunellae.In addition, this product still has the expelling wind and activating blood circulation effect, can be used for muscles and bones aching, and falls and pounces on grieved grade for disease.

Flos Magnoliae is the alabastrum of Magnoliaceae machaka plant Magnolia liliiflora (Magnolia liliiflora Desr.), enter lung meridian, on lead in nose, with dispersing wind and cold, so be used for the treatment of clinically the nasal sinusitis disease of the how turbid tears of nose, anosmia, normal and the compatibility application such as the Radix Angelicae Dahuricae, Herba Asari, Radix Saposhnikoviae, Fructus Xanthii.Local convergence, stimulation and anesthetic action: 0.2% aromatic water of Flos Magnoliae volatile oil or 2% Emulsion splash in the rabbit conjunctival capsule, can make immediately the iris vessels expansion, and pupil is slightly loose large; Directly drip on rabbit undertissue or intestinal mucosa, can produce one deck protein coagulation thing, mucosa becomes opaque milky, and vein is slightly expanded, and Marjoram Extract is more remarkable; 1:1 Flos Magnoliae extractum or 1:4 decoct show the infiltration anesthesia effect to the Cavia porcellus subcutaneous injection, and the Flos Magnoliae saturated solution has the block anesthesia effect to frog sciatic nerve.

Radix Angelicae Dahuricae meridian distribution of property and flavor: suffering, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.Analgesic, analgesia and antiinflammatory action: the Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 15g(crude drug)/the kg gavage, the rabbit that generates heat due to the subcutaneous injection peptone of back there is the trivial solution heat effect, its effect is better than the aspirin of 0.1g/kg. Radix Angelicae Dahuricae decoct, ether extract and water extract 8g(crude drug)/the kg gavage, suppression ratio to the reaction of mice acetic acid twisting is respectively 69.6%, 52.86% and 40.53%; The hot plate method in mice test also makes the pain approve obviously improve Radix Angelicae Dahuricae decoct 4g(crude drug)/the kg gavage, xylol rouses mice ear inflammation also obvious inhibitory action.Other has report, and the Radix Angelicae Dahuricae is to folder tail and boiling hot tail induced pain unrestraint effect.

Contain the multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in the Herba Taraxaci plant, the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, and abundant nutritive value is arranged, and is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Nature,taste and action: sweet, little hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Cure mainly: upper respiratory tract infection, eye conjunctivitis, mumps, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder is assisted inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.

Fructus Forsythiae is bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae mainly is fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.Have the effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in the prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.The mongolian medicine bitter in the mouth, cool in nature.Clearly " association's day ", antidiarrheal.Cure mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.The Sheng Nong's herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.

Herba Houttuyniae is hot, is slightly cold.Return lung meridian, be used as medicine, the traditional Chinese medical science is thought its acrid in the mouth, cold, skin ulcer, promoting urination to remove dampness, invigorating the stomach and promoting digestion are treated in energy heat-clearing and toxic substances removing, the detumescence of row's pain, be the lung abscess suffered from, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. with controlling excess-heat, pyretic toxicity, damp, disease heat, alone or compatibility compound recipe, the equal determined curative effect of the use of oral administration and externally or multiple Dietotherapy method among the people.Pharmacological research, the Herba Houttuyniae master contains volatile oil, and the multiple components such as decanoylacetaldehyde houttuynine sodium bisulfite have the inhibition antibacterial action to various Xenorhabduses, coccus, influenza virus, leptospira etc., and can improve the human immunity regulatory function.

The Flos Chrysanthemi acrid in the mouth, sweet, hardship; Cold nature.Return lung, Liver Channel.Loose wind heat clearing away, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.Calmness, refrigeration function are arranged.Staphylococcus aureus, group B streptococcus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, bacillus pyocyaneus, mycobacterium hominis and influenza virus all there is inhibitory action.Obviously coronary artery dilator, and increase blood flow.Can strengthen capillary resistance.The chrysanthemum glycoside has hypotensive effect.Be used for cold anemopyretic, heating is dizzy; Liver Channel has heat; The many tears of conjunctival congestion, or the hepatic and renal YIN deficiency, eyes is dim-sighted; Excessive rising of liver-YANG, dizziness and headache; Skin infection swells and ache.Modern times are used for again coronary heart disease, hypertension

The loose poison of Flos Lonicerae heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate the effect traditional Chinese medical science such as immunity and think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat the diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.The Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay Respirovirus to the pathological changes effect of cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Flos Lonicerae preparation lumbar injection can reduce obviously that the leukocyte count of rabbit descends due to the endotoxin of bacillus pyocyaneus, and deviation to the left phenomenon etc. has obvious antagonism.Flos Lonicerae compatibility Radix Scutellariae is prepared into poisoning symptom and the death that preparation can obviously alleviate bacillus pyocyaneus endotoxin caused rabbit.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are used in the fungal culture miscellaneous bacteria and infect special severity by the strong characteristics of broad-spectrum antibacterial action, and are fine with Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: so bitter in the mouth dampness; So YIN-cold wins heat, so main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, the disease of all damp and hot victory is also analysed it, then all diseases are from recover.Bitter cold can be except damp and hot, thus small intestinal profit and water from pursuing, the source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, instant heating human blood chamber, it is obstructed to make us amenorrhea, damp and hot solution, then Ying Qi is clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood is then stayed knot, and is that carbuncle stain is mashed also: the acute scleritis person, the fire of moxibustion blood trouble also, the removing heat from blood heat extraction, then spontaneous recovery also.Radix Scutellariae has antiallergic action and antiinflammatory action: the contained baicalin of Radix Scutellariae and baicalin can obviously suppress the anaphylaxis contractile response that sensitized guinea pig rat small intestine in vitro and isolated tracheal produce antigen, to passive general allergy and the Cavia porcellus passivity skin allergic reaction of Cavia porcellus and mice, baicalin and baicalin also have inhibitory action.Radix Scutellariae has refrigeration function, most evidences, and the active ingredient baicaligenin of Radix Scutellariae has refrigeration function.Radix Scutellariae has Detoxication, and baicalin has obvious Detoxication, and this may be because under the effect of glucuronidase, and baicalin decomposites glucuronic acid, and with due to multiple poisonous substance is combined.10 milligrams of LD 50 that can improve strychnine of baicalin reach 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mice is increased.

The Radix Astragali is take tonify deficiency as main, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of for a long time disunion.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation of some infectious disease of prevention." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Herba Menthae is one of Chinese conventional Chinese medicine.It is hot cold sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.But place's training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The Herba Menthae of light friend Greenhouse Fruit Picking is again the fresh vegetable on the dining table in the Spring Festival.Clearly good to eat.Usually with Herba Menthae for tea, clearing away heart-fire makes eye bright.Herba Menthae has extremely strong sterilization antibacterial action, often drinks its energy preventing viral flu, oral disease, makes breath freshening.Gargle with mint tea juice, can be anti-halitosis in advance.Steam face with the mint tea mist, also have the effect of shrinking pore.Take the blade that steeped tea to apply and on eyes, can feel refrigerant, can remove eyestrain.It is said that Herba Menthae also has the another name of " eyes grass ", can be used for treating ophthalmic.

Borneolum Syntheticum is used for conjunctival congestion and swelling pain, sore throat aphtha.The Borneolum Syntheticum bitter cold has the merit of clearing away heat to alleviate pain, detumescence, is the department of eye common medicine.Treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue, normal and Borax, Cinnabaris, Matrii Sulfas Exsiccatus grind to the powder altogether, blow deposited affected part, such as BINGPENG SAN.The treatment acute pharyngitis due to wind-heat is used for skin infection and swells and ache, and does not hold back after bursting.This product also has heat-clearing and toxic substances removing, erosion prevention and muscle growing effect.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters the blood chamber, and delirium is gone mad; Or blood is vexed interior swollen, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.It is all that cold and heat are handed over work as amenorrhea is obstructed, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are long-pending, or skin infection sufferings and swollen burst uneasyly, be cards of disharmony between QI and blood all, non-Flos Carthami can not be transferred, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, the thrombosis of inhibition, antiinflammatory, analgesic effect are arranged, have the vasoconstrictive effect of eliminating epinephrine, norepinephrine, " tonneau passages through which vital energy circulates " effect is arranged.

Rhizoma Chuanxiong is hot, temperature.Enter liver, gallbladder meridian.Activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." herbal classic " carries it: main apoplexy enters the brain headache, arthralgia due to cold, and the clonic spasm of the muscle emergency, the gold wound, married woman's blood closes loss of fecundity." not Lu " carries it: " except cold moving in the brain, urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, the soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." be the good medicine of regulating qi to disperse stagnation.

Herba Schizonepetae is hot, tepor.Return lung, Liver Channel.The loose wind that induces sweat, rash.Be used for flu, headache, measles, rubella, skin infection from the beginning of.The parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Horse Herba Schizonepetae one medicine is given birth to the effect that expelling pathogenic wind from the body surface is arranged, and parch to black then is used for hemostasis.Join Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, control wind and cold table disease; Join Flos Lonicerae, Fructus Forsythiae, Herba Menthae, control wind heat table disease; Join Gypsum Fibrosum, control headache due to pathogenic wind-heat; Join Fructus Arctii, Radix Platycodonis, Radix Glycyrrhizae, control laryngopharynx swelling and pain; Join charred Flos Sophorae, treating hematochezia; Join Rhizoma Imperatae, control epistaxis.Herba Schizonepetae and Folium Perillae all can relieving the exterior syndrome by diaphoresis, but Folium Perillae cold expelling power is strong, partially enters edema caused by disorder of QI, again can regulating the flow of QI to ease the stomach; And the Herba Schizonepetae power of dispeling the wind wins, and partially enters blood system, and parch to black can stop blooding again.So Folium Perillae commonly used in the side of regulating the flow of vital energy, and in the middle of blood-regulating prescription multiplex Herba Schizonepetae.

Radix Platycodonis is the dried roots of Campanulaceae Radix Platycodonis, bitter in the mouth, suffering, slightly warm in nature.Enter lung meridian.The energy expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged.Contained platycodin makes the sputum dilution to the direct stimulation of oral cavity, throat, gastric mucosa thereby reflexive ground increases the bronchial mucosa hypersecretion, is easy to discharge; Radix Platycodonis has antitussive effect, and the antiinflammatory of enhancing and immunization are arranged, and its antiinflammatory intensity is similar to aspirin; Water extract can strengthen the phagocytic function of macrophage, strengthens the sterilizing power of neutrophilic leukocyte, improves lysozyme activity; Stress ulcer there is preventive effect.The thick saponin of Radix Platycodonis has calmness, analgesia, refrigeration function, again can blood sugar lowering, cholesterol reducing, and relaxing smooth muscle.Platycodin has very strong haemolysis, but destroy and lose haemolysis oral can the decomposition in digestive tract.

Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature.Return bladder, liver, spleen channel.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Cure mainly the diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.Be used for headache due to common cold, the rubella pruritus.Control exterior syndrome due to wind-cold, headache general pain, aversion to wind and cold person, Chang Peiwu Herba Schizonepetae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis etc.; Control diseases caused by exogenous pathogenic factor rheumatism, the headache as wrap up in, heavy sensation of the body acroesthesia person, be equal to usefulness with Rhizoma Et Radix Notopterygii, Rhizoma Ligustici; Control the rubella pruritus, polygamy 5 Radix Sophorae Flavescentiss, Herba Schizonepetae, Radix Angelicae Sinensis etc.

Olibanum is arduous, temperature.Regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge." not Lu ": it be swollen to treat the edema due to wind pathogen poison, removes bad odor.Treat the urticaria poison of itching.Supplement to the Herbal: treat deaf, the apoplexy locked mouth, married woman's vim and vigour can be sent out wine, manage air-cooledly, only large intestine is let out Bleach, treats all skin ulcers and makes internal diabetes.

Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation.Be used for hemoptysis and spit blood traumatic hemorrhage, sore swollen toxin, chapped skin; The pulmonary tuberculosis hemoptysis, ulcer haemorrhage.1. anastalsis: it is active that Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen the platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses the plasmin enzymatic activity, and local hemorrhage is had anastalsis; Zoopery shows, the external haemostatic effect is quite good to parenchymatous organ's (liver, spleen), muscle vascular be hemorrhage etc. for the Pseudobulbus Bletillae (Rhizoma Bletillae) water extraction.2. protection gastric mucosa: 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, the rat pipe film injury that hydrochloric acid is caused has protective effect; Experimental Stomach duodenum perforation has therapeutical effect to anesthetized dog.3. antibiotic, antifungic action: the immersion of Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to staphylococcus aureus, bacillus subtilis, Bacillus tuberculosis; The water logging agent has inhibitory action to microsporon audouini; Contained 3 biphenyl classes and 2 the luxuriant and rich with fragrance compounds of two hydrogen of Pseudobulbus Bletillae (Rhizoma Bletillae) have inhibitory action to staphylococcus aureus, bacillus subtilis, Candida albicans ATCC1057 and Trichophyton QM248.

Herba Asari, the Chinese medicine name cures mainly: dispels the wind, cold expelling, row water is had one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.All herbal medicine is with being analgesic, diuresis, analgesia, tranquilizer.Control headache, the effect of diaphoresis is arranged, eliminating the phlegm.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; The phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.The refrigeration function Herba Asari volatile oil gavages has obvious refrigeration function to many reasons such as Wen Cifa, tetrahydrochysene beta-naphthylamine, typhoid fever, the caused rabbit experiment heat pyrexia of paratyphoid fever mixed vaccine, and the rat fever due to the beer yeast is also had obvious solution thermal effect.Can also reduce the body temperature of normal rat.

The manufacturing process of endo-medicine honey refining pill of the present invention is: first Herba Xanthii 1000g, Rhizoma Cyperi 1000g, Flos Lonicerae 1000g distillation are crystallized into powder; Get again surplus stock medicine Radix Angelicae Sinensis 1000g, Fructus Forsythiae 1000g, Semen Benincasae 1000g, Rhizoma Chuanxiong 1000g, Radix Platycodonis 1000g, Caulis Sargentodoxae 1000g, Herba Houttuyniae 1000g, Radix Astragali 1000g, Flos Magnoliae 1000g, Radix Angelicae Dahuricae 1000g, Radix Scutellariae 1000g, Herba Taraxaci 1000g, Herba Schizonepetae 1000g; The 60-90% soak with ethanol that adding 5-10 doubly measures 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, the 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into the extractum shape, stand for standby use becomes component 1; Medicinal residues add 5-10 times of water gaging and soaked 1-2 hour, extract 1 time in 1-1.5 hour, as component 2; Above-mentioned two kinds of extractum are condensed into pasty state, add the powder that above-mentioned distillation obtains, add Mel and be twisted into pill.

The preparation process of endo-medicine capsule of the present invention is: get Herba Xanthii 1000g, Rhizoma Cyperi 1000g, Flos Lonicerae 1000g, Radix Angelicae Sinensis 1000g, Fructus Forsythiae 1000g, Semen Benincasae 1000g, Rhizoma Chuanxiong 1000g, Radix Platycodonis 1000g, Caulis Sargentodoxae 1000g, Herba Houttuyniae 1000g, Radix Astragali 1000g, Flos Magnoliae 1000g, Radix Angelicae Dahuricae 1000g, Radix Scutellariae 1000g, Herba Taraxaci 1000g, Herba Schizonepetae 1000g; The above-mentioned raw materials medical material is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; The medicinal residues that refined are put into 10 times of water gagings, and heating and refluxing extraction 3 times each 45 minutes～1 hour, merges filtering and standing with 3 extracting solution; Above-mentioned two kinds of filtrates are merged, and decompression recycling ethanol and to be concentrated into liquor strength be 0.4g crude drug/mL is behind the sucking filtration, when the relative density of filtrate is about 20 ℃ 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, uses first deionized water or the distilled water eluting of 10 times of resin column volumes, uses 95% ethanol elution of 5 times of resin column volumes again, collects ethanol elution, removes solvent, obtains raw material medicated powder and incapsulates.

Endo-medicine method for preparing tablet thereof of the present invention: with Herba Taraxaci 1500g, Radix Scutellariae 1500g and Fructus Forsythiae 1500g put into 10 times of amount ethanol, heating and refluxing extraction 2 times, and each 1～2 hour, extract active ingredient, 2 extracting solution are merged leave standstill; Get again surplus stock Herba Xanthii 1500g, Rhizoma Cyperi 1500g, Radix Angelicae Sinensis 1500g among the above-mentioned side, Flos Lonicerae 1500g, Semen Benincasae 1500g, Rhizoma Chuanxiong 1500g, Radix Platycodonis 1500g, Caulis Sargentodoxae 1500g, Herba Houttuyniae 1500g, Radix Astragali 1500g, Flos Magnoliae 1500g, Radix Angelicae Dahuricae 1500g, Herba Schizonepetae 1500g; Put into 10 times of water gagings, heating and refluxing extraction 3 times each 30 minutes～1 hour, merges 3 extracting solution to leave standstill and adds the water heating and refluxing extraction; Above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrate is about 1.08 (20 ℃); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, uses first deionized water or the distilled water eluting of 10 times of resin column volumes, uses 95% ethanol elution of 5 times of resin column volumes again, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.

The preparation method of external drop of the present invention is: extracting honeysuckle 1000g, Rhizoma Cyperi 1000g, Borneolum Syntheticum 1000g, Herba Menthae 1000g, Herba Asari 1000g, Flos Chrysanthemi 1000g; Flos Carthami 1000g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1000g, Radix Saposhnikoviae 1000g, Olibanum 1000g.First all raw medicinal materials are distilled with steam method, obtain crystal; Then distillation test residue is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing, remove supernatant; The crystal of distillation extraction is put into filtrate, soak 5-10 days available; Can directly splash into nasal cavity 2-5 during use and drip, face upward head and allow medicinal liquid nasal cavity profit reduction and reserving 5-10 minute, perhaps after medicinal liquid soaks, fill in nasal cavity 10-20 minute with the Cotton Gossypii of sterilizing.

The preparation method of externally used paste of the present invention: extracting honeysuckle 1500g, Rhizoma Cyperi 1500g, Borneolum Syntheticum 1500g, Herba Menthae 1500g, Herba Asari 1500g, Flos Chrysanthemi 1500g; Flos Carthami 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Radix Saposhnikoviae 1500g, Olibanum 1500g obtains crystal with the steaming process distillation, is ground into fine powder; Then medicinal residues are extracted 2 times with ethanol heat, extract is left standstill, remove supernatant; The crystal that distillation is obtained mixes with the medicinal liquid of extraction and is condensed into paste, adds the vaseline paste making agent.Can directly smear during use.

Pharmacology's toxicity test

The acute toxicity testing data

1, experimental technique

Guinea pig back spinal column both sides are evenly coated depilatory, make about 20 square centimeters of unhairing scope.Clean depilatory returns cage to observe 24 hours, every group of Cavia porcellus is coated with respectively Chinese medicine preparation external drop 0.2,0.4 of the present invention and 0.8ml, contain respectively crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, and a continuous week is after experiment finishes, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin are done pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin and contrast word more also no significant difference.

Results suggest, Chinese medicine for external application of the present invention also have no the general toxicity performance without local irritant effect.Show that Chinese medicine for external application of the present invention uses safety.

The long term toxicity test data

1, experimental technique

Cavia porcellus at random part is become 4 groups, 15 every group.In guinea pig back spinal column both sides depilatory is evenly coated, made about 20 square centimeters of its depilation scope.Clean depilatory, observe after 24 hours every group of Cavia porcellus and be coated with respectively innerwear Chinese medicine preparation capsule 0.2 of the present invention, 0.4 and 0.8ml, contain respectively crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, put to death animal after experiment finishes and carry out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity activity, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, experiment is respectively organized the heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.

The aggregate toxicity experiment:

Chinese medicine preparation oral capsule of the present invention to mice by 7.69,19.18 and the 43.21g crude drug/15 weeks of kg continuous use (1.0ml/100g body weight, every day 2 times) and after 3 week of drug withdrawal, the result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 15 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation oral capsule of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

Pharmacological experiment

One: the external used medicine experiment material

L.1 laboratory animal Kunming kind white mice is 58, about body weight 20 g, and male and female half and half.Provided by Shandong medical college Experimental Animal Center.

1. 2 medicines and reagent Chinese herbal irrigative solution: Flos Lonicerae 15g, Rhizoma Cyperi 10g, Borneolum Syntheticum 10g, Herba Menthae 15g, Herba Asari 10g, Flos Chrysanthemi 15g; Flos Carthami 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Saposhnikoviae 15g part, Olibanum 15g; Fluocinonide ointment is produced (batch number: 06121) by Tianjin Pacific Pharmaceutical Co., Ltd.

1.3 experimental technique

L.3. l acute toxicity testing: only get white mice l8, male and female half and half are divided into normal saline matched group (matched group) and the concentrated liquid of tradition Chinese medicine treatment group (treatment group) at random, make marks with picric acid respectively.Use respectively 0.9% normal saline and the concentrated liquid of tradition Chinese medicine (during test irrigating solution being concentrated 35 times) collunarium, every day 8 times, successive administration 7 d for two groups.Behind administration 7 d, the ordinary circumstance of perusal two treated animal whole bodies is such as behavior, state, sign, amount of drinking water, the situation of ingesting, defecation character, body weight and the nasal mucosa irritation of mice.The perusal nasal mucosa changed after mice was put to death in cervical vertebra fracture, comprised the nasal mucosa color and luster, had or not hyperemia, edema, hemorrhage, ulcer etc. and each organ of mice has or not obvious change.

1.3.2 anti-chronic granuloma hypertrophy experiment

40 mices are divided into 4 groups of model group, the high low dose group of Chinese herbal irrigative solution and fluocinonide matched groups, 10 every group at random.Each organizes the mice sterile working, behind the Mus back of the body alcohol disinfecting in subcutaneous injection 2% agar solution 0.4 mL of Mus dorsal line place, then use respectively 0.9% normal saline, high dose Chinese herbal irrigative solution (8.4 g/kg), low dosage Chinese herbal irrigative solution (4.2 g/kg) and the fluocinonide ointment (2 mg/kg) of equivalent to smear the Mus back of the body, every day 2 times, continuous 7 d.Behind last administration 24 h, mice is put to death in the cervical vertebra fracture, carefully separates the granuloma agar block, takes by weighing weight in wet base, observes contrast and respectively organizes mice granuloma agar block weight in wet base.

2 statistical methods

Measurement data is with (t check between the expression of x ± S), capable group of SPSS10.0 software.

3 results

3.1 general status

Abnormal response does not appear in each animal 8 intranasal administration every day, Continuous Observation 7 d, two groups of mice outward appearance hair color lights, behavior, state, movable normal, occur without unusual pathologic neural reflex, ingest good, amount of drinking water is normal, has no other Novel presentations such as loose stool, hematuria, body weight is without obvious change.The nasal mucosa color is light red, occurs without edema, hemorrhage and ulcer, also occurs without the irritation of nasal mucosa such as sneeze, watery nasal discharge.After two groups of mices become celestial, the organs such as the perusal heart, liver,spleen,kidney, lung, Stomach duodenum, its size, form, color and luster, texture are showed no unusually.

The results are shown in Table 1 3.2 respectively organize mice granuloma anharmonic ratio.

Table 1 is respectively organized mice granuloma anharmonic ratio

Annotate: compare P＜0.05 with model group

As shown in Table 1, in the anti-chronic granuloma hypertrophy experiment, compare with model group, all there were significant differences for fluocinonide group and Chinese herbal irrigative solution high dose group (P＜0.05), and the Chinese herbal irrigative solution low dose group is without significant difference.

Two, innerlich anwenden thing experiment

Impact on the Guinea Pigs otitis media

1, experimental technique

The selection body weight is 350 ± 30g male guinea pig random packet, and is aseptic lower to lumbar puncture needle perforation in the middle part of every Cavia porcellus auris dextra ear drum membrane, causes inflammation with being about to 0.1ml dimethylbenzene through perforation place injection middle ear.One group of Cavia porcellus auris dextra injects 0.08ml (46.6mg/ only) Chinese medicine preparation solution of the present invention after 30 minutes, and another group is injected equivalent solvent, continuous 12 days.Then the solvent group is only used Chinese medicine preparation of the present invention (oral capsule) 21.3mg/ instead, and the medication group continues administration, observes medicine in continuous six days to impact and the subacute toxicity of acute inflammation and hypertrophy variation again.It is the same that another batch test causes scorching method.Cause scorching rear 48 hours, one group of Cavia porcellus is only injected Chinese medicine preparation 42.6mg/ of the present invention in auris dextra, another group is injected the equivalent solvent, and observation index was that the inflammatory different time oozes out liquid measure total white blood cells and classification in continuous 4 days once a day, the general performance that how much reaches kind and inflammation of antibacterial.When experiment finishes, get external ear, tympanum, auditory ossicles and the heart, liver, kidney is done the pathology histological examination.

2, result

Scorching rear 30 minutes of caused by dimethylbenzene xylene, inject Chinese medicine preparation of the present invention (oral capsule) 0.08ml (42.6mg) in every Cavia porcellus auris dextra, compare with matched group, administration has no obvious transudate after 4 hours, red and swollen cancellation, the auditory meatus normal in size, continuous use 18 days, also have no tympanum, auditory ossicles and the heart, liver, kidney has obvious histopathology to change, and solvent disappears to impinging upon to rear 120 hours rednesses of inflammation, scar tissue appears in the road, and auditory meatus narrows down, and middle in ear sees that a large amount of focus neutrophilic leukocytees invade profit.Cause scorching rear the 12 day, this group is used Chinese medicine preparation of the present invention instead, once a day (42.6mg), continuous six, see that auditory meatus is tending towards normal size, scar tissue reduces, histopathologic examination shows, the appearance of external ear and tympanum and cartilage have no obvious pathological changes, and intradermal is seen two lymph nodes, are reactive hyperplasia and change.The above results prompting: Chinese medicine preparation of the present invention not only has inhibitory action but also hypertrophy is also had certain antagonism acute transudate, this medicine continuous application 18 days, and do not regard sb. as an outsider middle ear and the heart, liver, kidney have obvious histopathology to change.Middle ear only ooze out the right injection 42.6mg/ in peak period (48 hours) after the caused by dimethylbenzene xylene inflammation, and Chinese medicine preparation of the present invention is treated two days later, and transudate and cell number obviously reduce (P＜0.05) redness and disappear.Cavia porcellus in ear transudate antibacterial culturing and count of bacteria result show, (namely ooze out the peak period) before the administration, in the Cavia porcellus ear transudate of test group, take golden Portugal bacterium as main, bacterial population is (1,600 ten thousand, 3,360,000 and 100,000,000/ml) and medication two days (causing scorching rear 96 hours), the bacterial population in the transudate be (without bacterial growth, 34 and 170,000/ml).Compare after the medication with before the medication, bacterial population obviously reduces.And the bacterial population of matched group Cavia porcellus ear transudate by cause scorching rear 48 hours (23.5 10,000 19 ten thousand and 450,000/ml) rise to 96 hours (4,400,000,1,200,000 and 85.6 ten thousand/ml).The above results prompting, Chinese medicine preparation of the present invention can not only reduce oozes out and treats acute inflammation and the cell infection that causes after the inflammation is also had obvious bacteriostasis.

Clinical data

1 object and method

1.1 object child patient 200 examples are divided into matched group 5O example, male 35 examples, women 15 examples, 3～6 months 24 examples of the course of disease, 7～12 months 17 examples, above person's 9 examples of 1 a at random; Treatment group 150 examples, male 90 examples, women 60 examples, 3～6 months 62 examples of the course of disease, 7～12 months 78 examples, above 10 examples of 1 a.Two groups of ages are asking in 6-14 year all.

1.2 diagnostic criteria reference " otolaryngology " clinical manifestation: nasal obstruction, many pus tears; Some patients were is with headache, and is vexed swollen, hyposmia, and medical history is person more than 3 months.Sign: nasal mucosa is in various degree hyperemia, swelling or plumpness, and middle nasal concha hypertrophy or Polypoid changes have a large amount of puss in the middle nasal meatus.Larger child's row x line or CT examination: nasal cavity is fuzzy, increase in density, and hole wall mucosa thickens, sometimes visible fluid level.The older maxilla of children hole of minority is punctured with pus and extracts out.

1.3 Therapeutic Method treatment group: take oral medicine of the present invention, the side uses: Radix Angelicae Sinensis 10g, Herba Xanthii 15g, Rhizoma Cyperi 10g, Fructus Forsythiae 10g, Semen Benincasae 15g, Rhizoma Chuanxiong 10g, Radix Platycodonis 15g, Caulis Sargentodoxae 10g, Herba Houttuyniae 15g, Radix Astragali 10g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 10g, Radix Scutellariae 10g, Herba Taraxaci 15g, Flos Lonicerae 10g, Herba Schizonepetae 10g makes honey refining pill, 6～8 years old each 5 g of child, 9～12 years old each 7.5 g, 13-14 years old each 10 g, equal 3 times/d.Boiled water is taken after mixing it with water, and 20 d are a course for the treatment of.External drop of the present invention, the side uses: Flos Lonicerae 15g, Rhizoma Cyperi 10g, Borneolum Syntheticum 10g, Herba Menthae 15g, Herba Asari 10g, Flos Chrysanthemi 15g; Flos Carthami 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Saposhnikoviae 15g part, Olibanum 15g.Matched group: 1 week of Administration of roxithromycin.The while nasal cavity splashes into 0.5% ephedrine liquid, 5 ml and adds gentamycin 40,000 U, 3 times/d collunarium, and 2 weeks were a course for the treatment of.

1.4 efficacy assessment standard (1) clinical recovery: clinical symptoms, sign disappear, and follow up a case by regular visits to 3 months without recurrence.(2) produce effects: nasal obstruction alleviates, and the pus tears obviously reduce, and headache disappears.(3) effectively nasal obstruction slightly alleviates, the attenuation of pus tears, and headache alleviates.(4) invalid: clinical symptoms, sign are without change.

I.5 statistical procedures uses SPSS 12.0 softwares to carry out statistical analysis, and each group asks that mean relatively adopts one factor analysis of variance, and group is asked in twos and relatively adopted.Check.There is significance P＜0.05 for difference.

2 results

Matched group 22 examples of fully recovering account for 44%; Produce effects 11 examples account for 22%; Effective 8 examples account for 16%; No effect 9 accounts for 18%, total effective rate 82%.Treatment group 98 examples of fully recovering account for 65.33%; Produce effects 32 examples account for 21.33%; Effective 15 examples account for 10%; Invalid 5 examples account for 3.33%.Total effective rate accounts for 96.66%.Through checking two groups of differences that significance (P＜O.05) is arranged.

Specific embodiment 1: clock, the man, 10 years old, in March, 2008 was medical.Readme: nose is responsive, often feels stuffiness, 5 d causes flu.Disease is seen: it is obstructed to have a stuffy nose, and flows yellow pus tears, little frowziness, and the forehead distending pain, superciliary ridge has tenderness, heating, 38.6 ℃ of body temperature, the enlargement of bilateral concha nasalis inferior, mucosa is scarlet.Red tongue, yellow fur, floating and rapid pulse.Card belongs to: wind heat is stopped up pulmonary type, and controlling should wind and heat dispersing, the tears of dispelling are sensible.Side's medicine: Radix Angelicae Sinensis 10g, Herba Xanthii 15g, Rhizoma Cyperi 10g, Fructus Forsythiae 15g, Semen Benincasae 10g, Rhizoma Chuanxiong 10g, Radix Platycodonis 15g, Caulis Sargentodoxae 10g, Herba Houttuyniae 15g, Radix Astragali 10g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 15g, Radix Scutellariae 10g, Herba Taraxaci 15g, Flos Lonicerae 10g, Herba Schizonepetae 15g, 1 d1 agent; External: Flos Lonicerae 15g, Rhizoma Cyperi 10g, Borneolum Syntheticum 10g, Herba Menthae 15g, Herba Asari 10g, Flos Chrysanthemi 15g; Flos Carthami 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Saposhnikoviae 15g part, Olibanum 15g makes drop; Cooperate Chinese medicine plug nose method and massotherapy.Be used in conjunction 7 d, nasal obstruction is light, and the pus tears are few, and heating is moved back, and the forehead distending pain obviously alleviates; The top plus-minus shares 30 d, sick announcement recovery from illness.Massaged continuously 3 months again for consolidating curative effect, follow up a case by regular visits to so far not recurrence.

Specific embodiment 2: Chen, woman, 5 years old.The sick child is not healed because of flu, nasal obstruction, many pus tears; With headache, vexed expanding, hyposmia, medical history is person more than 3 months.Sign: nasal mucosa is in various degree hyperemia, swelling or plumpness, and middle nasal concha hypertrophy or Polypoid changes have a large amount of puss in the middle nasal meatus.Carry out CT examination: nasal cavity is fuzzy, increase in density, and hole wall mucosa thickens; Be diagnosed as chronic sinusitis.The side uses: Radix Angelicae Sinensis 15g, Herba Xanthii 15g, Rhizoma Cyperi 10g, Fructus Forsythiae 15g, Semen Benincasae 15g, Rhizoma Chuanxiong 10g, Radix Platycodonis 15g, Caulis Sargentodoxae 10g, Herba Houttuyniae 15g, Radix Astragali 10g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 10g, Radix Scutellariae 10g, Herba Taraxaci 15g, Flos Lonicerae 10g, Herba Schizonepetae 15g, 1 d1 agent; External: Flos Lonicerae 15g, Rhizoma Cyperi 15g, Borneolum Syntheticum 10g, Herba Menthae 15g, Herba Asari 10g, Flos Chrysanthemi 10g; Flos Carthami 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Saposhnikoviae 15g part, Olibanum 15g makes drop.After being used in conjunction 7 d, nasal obstruction is light, and the pus tears are few, and heating is moved back, and the forehead distending pain obviously alleviates; The top plus-minus shares 36 d, sick announcement recovery from illness.Massaged continuously 4 months again for consolidating curative effect, follow up a case by regular visits to so far not recurrence.

Specific embodiment 3: the side certain, man, 8 years old.Because flu causes a large amount of stickiness or purulence nasal mucus, nasal obstruction, headache, giddy, acute nasal sinusitis occur together heat and General Symptoms; The nasal cavity inspection shows that mucosa is congested, swelling, and nasal cavity or choana have more stickiness or purulent secretion.The x line is taken the photograph sheet positive performance, the dense shadow of the increase in density of hole chamber, hole cavity edge different-thickness, the visible fluid level of intracavity etc.Be diagnosed as chronic sinusitis.The side uses: Radix Angelicae Sinensis 15g, Herba Xanthii 10g, Rhizoma Cyperi 10g, Fructus Forsythiae 15g, Semen Benincasae 15g, Rhizoma Chuanxiong 10g, Radix Platycodonis 15g, Caulis Sargentodoxae 10g, Herba Houttuyniae 15g, Radix Astragali 15g, Flos Magnoliae 10g, Radix Angelicae Dahuricae 10g, Radix Scutellariae 10g, Herba Taraxaci 15g, Flos Lonicerae 10g, Herba Schizonepetae 10g, 1 d1 agent; External: Flos Lonicerae 15g, Rhizoma Cyperi 15g, Borneolum Syntheticum 10g, Herba Menthae 15g, Herba Asari 10g, Flos Chrysanthemi 15g; Flos Carthami 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Saposhnikoviae 15g part, Olibanum 15g makes drop.After being used in conjunction 5 d, nasal obstruction is light, and the pus tears are few, and heating is moved back, and the forehead distending pain obviously alleviates; The top plus-minus shares 36 d, sick announcement recovery from illness.Massaged continuously 3 months again for consolidating curative effect, follow up a case by regular visits to so far not recurrence.

Claims

1. a Chinese medicine composition for the treatment of children chronic sinusitis is characterized in that, formed by endo-medicine and external used medicine,

The ratio of weight and number of various crude drug is in the described endo-medicine: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Herba Xanthiis, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Semen Benincasaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Platycodoniss, 10～20 parts of Caulis Sargentodoxaes, 10～20 parts of Herba Houttuyniae, 10～20 parts of the Radixs Astragali, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Schizonepetae;

2. the Chinese medicine composition of described treatment children chronic sinusitis according to claim 1 is characterized in that,

The ratio of weight and number of various crude drug is in the described endo-medicine: 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Herba Xanthiis, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Semen Benincasaes, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Radix Platycodoniss, 10～20 parts of Caulis Sargentodoxaes, 10～15 parts of Herba Houttuyniae, 10～15 parts of the Radixs Astragali, 10～15 parts of Flos Magnoliaes, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Radix Scutellariaes, 10～15 parts of Herba Taraxacis, 10～15 parts of Flos Loniceraes, 10～15 parts of Herba Schizonepetae;

The ratio of weight and number of various crude drug is in the described external used medicine: 10～15 parts of Flos Loniceraes, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Borneolum Syntheticums, 10～15 parts of Herba Menthaes, 10～15 parts of Herba Asaris, 10～20 parts of Flos Chrysanthemis; 10～20 parts on Flos Carthami, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Olibanums.

3. the Chinese medicine composition of described treatment children chronic sinusitis according to claim 1 is characterized in that,

The ratio of weight and number of various crude drug is in the described endo-medicine: 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Herba Xanthiis, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Semen Benincasaes, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Radix Platycodoniss, 10～15 parts of Caulis Sargentodoxaes, 10～20 parts of Herba Houttuyniae, 10～20 parts of the Radixs Astragali, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Flos Loniceraes, 10～20 parts of Herba Schizonepetae;

The ratio of weight and number of various crude drug is in the described external used medicine: 10～20 parts of Flos Loniceraes, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Borneolum Syntheticums, 10～20 parts of Herba Menthaes, 10～20 parts of Herba Asaris, 10～15 parts of Flos Chrysanthemis; 10～20 parts on Flos Carthami, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Radix Saposhnikoviaes, 10～20 parts of Olibanums.

4. one kind such as the preparation method of the Chinese medicine composition for the treatment of children chronic sinusitis as described in each in the claim 1～3, it is characterized in that the dosage form of described oral preparations is honey refining pill, and its preparation method comprises:

5. described preparation method according to claim 4, it is characterized in that, among the described step b, get crude drug and add 60-90% soak with ethanol 1-2 hour that 5-10 doubly measures, heating extraction 2 times, each 1-2 hour, get supernatant, merge extractive liquid,, the 80-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, extracts active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into the extractum shape, and stand for standby use becomes component 1; Among the described step c, medicinal residues add 5-10 times of water gaging and soaked 1-2 hour, extract 1 time in 1-1.5 hour, as component 2.

6. one kind such as the preparation method of the Chinese medicine composition for the treatment of children chronic sinusitis as described in each in the claim 1～3, it is characterized in that, described external used medicine dosage form is drop, and its preparation process is: first all raw medicinal materials are distilled with steam method, obtain crystal; Then distillation test residue is put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing, get supernatant; The crystal of distillation extraction is put into filtrate, soaked 5-10 days.