CN105497353A - Chinese herbal preparation for preventing and controlling children dermatosis and preparing method and application thereof - Google Patents
Chinese herbal preparation for preventing and controlling children dermatosis and preparing method and application thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to the technical field of external preparations for children, in particular to a Chinese herbal preparation for preventing and controlling children dermatosis and improving disease resistance of skin of children and the preparing method and application thereof. The Chinese herbal preparation is prepared from, by weight, 60-100 parts of radix sophorae flavescentis, 30-80 parts of cortex dictamni, 10-50 parts of wild honeysuckle flower, 10-50 parts of fructus kochiae, 5-35 parts of herba portulacae, 5-30 parts of cortex phellodendri, 5-30 parts of rhizoma acori graminei, 5-35 parts of folium artemisiae argyi and 5-35 parts of radix angelicae. The Chinese herbal preparation can achieve bacteriostasis and skin care, relieve itching and diminish inflammation, and improve disease resistance of skin of children, children skin anaphylaxis and irritation are avoided, and the Chinese herbal preparation is suitable for children reddish sudamen, urticaria, infantile eczema, diaper dermatitis, insect bite dermatitis and other symptoms.
Description
Technical field
The present invention relates to child's external preparation technical field, be specifically related to a kind of control children's dermatosis, strengthen the Chinese medicine preparation of children's's skin resistance against diseases, preparation method and application thereof.
Background technology
Children's's dermatosis mainly contains the disease such as miliaria alba, urticaria, infantile eczema (milk moss), diaper dermatitis, insect bite dermatitis, it is Common Pediatric Diseases, cause infant irritated, cry and scream, spirit is uneasy, the physical and mental health of serious harm infant, also brings many worries to infants ' parents.
The dermopathic particularity of children's is bearing a pretty, delicate skin of child, and its feature is that skin development is complete, body surface area is relatively large.Be in particular in that horny layer is thin, sebum secretion is few, Thermoregulation ability is poor, resistance is poor, and the aspect such as absorption per unit area amount is large, volume of perspiration is large, much often to the skin of child, injury is produced to the external preparation that adult is without any side effects, in addition on the market mostly also be chemical medicine preparation for the dermopathic medicament of children's, great majority rely on 17-hydroxy-11-dehydrocorticosterone, antibiotic etc., above-mentioned preparation is used for child and is often restricted, and there is many potential dangers, easily there is dependence facial dermatitis in life-time service, and the symptom such as local pigment calmness, hirsutism.In addition, the way of being carried out cutting down according to the circumstance for children ' s dermatosis by the consumption of adult's medication is at present not scientific and normal yet, often produces unpredictable injury to child.
Summary of the invention
In view of this, the application provides a kind of control children's dermatosis, strengthen the Chinese medicine preparation of children's's skin resistance against diseases, preparation method and application thereof, described Chinese medicine preparation has the effect of bacteriostatic skin-care, itch stopping and diminish inflammation, enhancing children's skin resistance against diseases, for children's's skin without anaphylaxis and zest, be applicable to the diseases such as children's's miliaria alba, urticaria, infantile eczema, diaper dermatitis, insect bite dermatitis.
For solving above technical problem, technical scheme provided by the invention is the dermopathic Chinese medicine preparation of a kind of control children's, the raw materials by weight portion meter of described preparation, comprising: Radix Sophorae Flavescentis 60-100 parts, Cortex Dictamni 30-80 parts, Flos Lonicerae 10-50 parts, the Fructus Kochiae 10-50 parts, Herba Portulacae 5-35 parts, Cortex Phellodendri 5-30 parts, Rhizoma Acori Graminei 5-30 parts, Folium Artemisiae Argyi 5-35 parts, the Radix Angelicae Dahuricae 5-35 parts.
Preferably, the raw materials by weight portion meter of described preparation, comprising: Radix Sophorae Flavescentis 70-90 parts, Cortex Dictamni 40-70 parts, Flos Lonicerae 20-40 parts, the Fructus Kochiae 20-40 parts, Herba Portulacae 10-25 parts, Cortex Phellodendri 10-25 parts, Rhizoma Acori Graminei 15-25 parts, Folium Artemisiae Argyi 15-30 parts, the Radix Angelicae Dahuricae 10-30 parts.
More preferred, the raw materials by weight portion meter of described preparation, comprising: Radix Sophorae Flavescentis 80 parts, Cortex Dictamni 60 parts, Flos Lonicerae 30 parts, the Fructus Kochiae 30 parts, Herba Portulacae 20 parts, Cortex Phellodendri 20 parts, Rhizoma Acori Graminei 20 parts, Folium Artemisiae Argyi 20 parts, the Radix Angelicae Dahuricae 20 parts.
Preferably, the raw materials by weight portion meter of described preparation also comprises: Aloe 2-15 parts, Radix Angelicae Sinensis 1-15 parts, Borneolum Syntheticum 1-10 parts.
More preferred, mark is counted by weight: Aloe 8-12 parts, Radix Angelicae Sinensis 8-12 parts, Borneolum Syntheticum 4-6 parts.
More preferred, mark is counted by weight: Aloe 10 parts, Radix Angelicae Sinensis 10 parts, Borneolum Syntheticum 5 parts.
Preferably, the dosage form of described preparation is washing liquid, also comprises pharmaceutically acceptable adjuvant in described preparation.
Technical scheme also provides a kind of preparation method of preventing and treating the dermopathic Chinese medicine preparation of children's, comprises the following steps:
(1) raw material of following parts by weight is taken: Radix Sophorae Flavescentis 60-100 parts, Cortex Dictamni 30-80 parts, Flos Lonicerae 10-50 parts, the Fructus Kochiae 10-50 parts, Herba Portulacae 5-35 parts, Cortex Phellodendri 5-30 parts, Rhizoma Acori Graminei 5-30 parts, Folium Artemisiae Argyi 5-35 parts, the Radix Angelicae Dahuricae 5-35 parts, Radix Angelicae Sinensis 1-15 parts, twice is decocted with water after mixing, first time adds 7-9 times of water yields, decocts 1-1.5 hours; Second time adds 5-8 times of water yields, decocts 0.5-1 hour, merges twice filtrate after filtering;
(2) take the Aloe that parts by weight are 2-15 parts, add in the filtrate after step (1) merging, after concentrated, leave standstill 10-15 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take the Borneolum Syntheticum that parts by weight are 1-10 parts, adopt the dissolve with ethanol of 95%, join in the concentrated solution of step (2) gained, after mix homogeneously and get final product.
Technical scheme also provides a kind of above-mentioned preparation in preparation treatment children's dermatosis, the application strengthened on the medicine of children's's skin resistance against diseases.
Preferably, described children's's dermatosis is miliaria alba, urticaria, infantile eczema, diaper dermatitis, insect bite dermatitis.
In technical scheme, Flos Lonicerae: sweet in the mouth, cold in nature, has heat-clearing and toxic substances removing, effect of dispelling wind and heat pathogens, treats skin ulcer, sore throat, erysipelas, toxic-heat and blood stasis, epidemic febrile disease for carbuncle.
Aloe: bitter in the mouth, cold in nature, has pathogenic fire purging, removing toxic substances, blood stasis dispelling, and effect of parasite killing, also has sterilization, antiinflammatory, moistening beauty treatment, and let out under stomach invigorating, heart tonifying is invigorated blood circulation, immunity and regeneration, immunity and antitumor, removing toxic substances, defying age, and analgesia is calm, anti-sunlight function.Constipation can be treated, nebulousurine, hematuria, pediatric epilepsy scared, infantile malnutrition, burn and scald, women's amenorrhea, hemorrhoid, scabies, carbuncle furuncle and phyma poison, traumatic injury.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, there is heat clearing and damp drying, parasite killing, effect of diuresis, for hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy.
Herba Portulacae: sour in the mouth, cold in nature, have heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of dysentery relieving, for toxic-heat and blood stasis, carbuncle furuncle, eczema, erysipelas, snake bite and insect sting, has blood in stool, hemorrhoidal bleeding, metrostaxis.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, have the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis, effect of dispelling wind for relieving itching, for anemofrigid cold, headache, toothache, rheumatic arthralgia, nasal sinusitis, leukorrhagia is demonstrate,proved, sore and toxic.
Cortex Dictamni: bitter in the mouth, cold in nature, have heat clearing and damp drying, the effect of removing toxic substances of dispeling the wind, for damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia.
The Fructus Kochiae: acrid in the mouth, hardship, cold in nature, there is clearing away heat-damp and promoting diuresis, effect of dispelling wind for relieving itching, for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Cortex Phellodendri: bitter in the mouth, cold in nature, have heat clearing and damp drying, pathogenic fire purging is except steaming, and effect of detoxification sore treatment, for damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, beriberi flaccidity is knitted, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.
Folium Artemisiae Argyi: acrid in the mouth, hardship, warm in nature, have warming the meridian for stopping bleeding, effect of dispersing cold for relieving pain, for removing dampness to relieve itching, spit blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, skin pruritus.
Rhizoma Acori Graminei: have and regulate the flow of vital energy, invigorates blood circulation, and loose wind, dries, removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, and effect of refreshment Fructus Alpiniae Oxyphyllae is not hungry for gastral cavity painful abdominal mass, to keep silent a mouthful dysentery, coma epilepsy, forgetful deafness, epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.
Borneolum Syntheticum: for the fresh branch and leaf of canella Borneolum Syntheticum Camphor tree are processed into through steam distillation and recrystallization, its acrid in the mouth, hardship, cold nature, GUIXIN, has delicate fragrance a surname loose, the loose poison of heat clearing away, effect of improving acuity of vision and removing nebula, for calentura unconsciousness due to high fever, apoplexy syncope due to accumulation of phlegm infantile convulsion, heat-damp in summer hoodwinks key clearly, sore throat is deaf, and aphtha tooth swells, carbuncle sore infantile malnutrition hemorrhoid, conjunctival congestion and swelling pain, pterygium.
Described miliaria alba is the shallow property of table, inflammatory dermatoses common under summer or hot environment, because of under the sultry environment of high temperature, a large amount of perspiration not easily evaporates, horny layer is made to flood swelling, sudoriferous duct narrows or blocks, cause perspiration retention, perspiration exosmoses surrounding tissue, form pimple, vesicle or pustule, be apt to occur in pleat position.
Described urticaria is a kind of localized edema reaction because skin, the expansion of mucosa thin vessels and permeability increase and occur, usually disappeared in 2-24 hours, but new erythra occurs repeatedly, the course of disease delay a few days is to the several months.
Described infantile eczema, is commonly called as infantile eczema, is a kind of allergic skin inflammation that is common, that caused by multiple internal and external factor.Skin lesion is that the pleomorphism being master by papulovesicle is damaged, and has and oozes out tendency, recurrent exerbation, and alternately, accompany violent pruritus, the cause of disease is often difficult to determine acute and chronic phase overlap.
Described diaper dermatitis refers to a kind of dermal inflammatory pathological changes occurred at the position of wrapping diaper, and also referred to as diaper rash or baby's diaper dermatitis, flushing, erythra appear in the skin showing as buttocks and diaper contact area, even occur festering and infecting.
Described insect bite dermatitis main and arthropodan bite relevant, common with spring, summer, autumn, due to the difference of caste and the difference of reactivity of organism, can cause and bite the different dermoreaction in place, be generally red edemous pimple, can there be phlysis in central authorities, Semen Glycines size, are apt to occur in exposure portion and waist week.
Technical scheme is for above-mentioned disease, dialectical medication, above-mentioned drug matching is adopted to form compound preparation, prevent, control combination, play the effect of raw material of Chinese medicine bacteriostatic skin-care, itch stopping and diminish inflammation, enhancing children's skin resistance against diseases, prove through test, technical scheme has antiinflammatory, antibacterial, antipruritic, antianaphylactic effect, in addition, for children's's skin without anaphylaxis, the disease such as children's's miliaria alba, urticaria, infantile eczema (milk moss), diaper dermatitis, insect bite dermatitis is applicable to.
Detailed description of the invention
In order to make those skilled in the art understand technical scheme of the present invention better, below in conjunction with specific embodiment, the present invention is described in further detail.
Embodiment 1
The dermopathic Chinese medicine preparation of one control children's described in the present embodiment, its raw materials by weight portion meter, comprising: Radix Sophorae Flavescentis 80 parts, Cortex Dictamni 60 parts, Flos Lonicerae 30 parts, the Fructus Kochiae 30 parts, Herba Portulacae 20 parts, Cortex Phellodendri 20 parts, Rhizoma Acori Graminei 20 parts, Folium Artemisiae Argyi 20 parts, the Radix Angelicae Dahuricae 20 parts, Aloe 10 parts, Radix Angelicae Sinensis 10 parts, Borneolum Syntheticum 5 parts.
Its preparation method is:
(1) take above-mentioned Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Fructus Kochiae, Herba Portulacae, Cortex Phellodendri, Rhizoma Acori Graminei, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, decoct with water twice after mixing, first time adds 8 times of water yields, decocts 1.5 hours; Second time adds 6 times of water yields, decocts 1.0 hours, merges twice filtrate after filtering;
(2) take above-mentioned Aloe, add in the filtrate after step (1) merging, after concentrated, leave standstill 12 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take above-mentioned Borneolum Syntheticum, adopt the dissolve with ethanol of 95%, join in the concentrated solution of step (2) gained, after mix homogeneously, be mixed with 1000ml, fill, packaging, to obtain final product.
Embodiment 2
The dermopathic Chinese medicine preparation of one control children's described in the present embodiment, its raw materials by weight portion meter, comprising: Radix Sophorae Flavescentis 60 parts, Cortex Dictamni 30 parts, Flos Lonicerae 10 parts, the Fructus Kochiae 10 parts, Herba Portulacae 5 parts, Cortex Phellodendri 5 parts, Rhizoma Acori Graminei 5 parts, Folium Artemisiae Argyi 5 parts, the Radix Angelicae Dahuricae 5 parts, Aloe 2 parts, Radix Angelicae Sinensis 1 part, Borneolum Syntheticum 1 part.
Its preparation method is:
(1) take above-mentioned Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Fructus Kochiae, Herba Portulacae, Cortex Phellodendri, Rhizoma Acori Graminei, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, decoct with water twice after mixing, first time adds 8 times of water yields, decocts 1.5 hours; Second time adds 6 times of water yields, decocts 1.0 hours, merges twice filtrate after filtering;
(2) take above-mentioned Aloe, add in the filtrate after step (1) merging, after concentrated, leave standstill 12 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take above-mentioned Borneolum Syntheticum, adopt the dissolve with ethanol of 95%, all join in the concentrated solution of step (2) gained, after mix homogeneously, be mixed with 1000ml, fill, packaging, to obtain final product.
Embodiment 3
The dermopathic Chinese medicine preparation of one control children's described in the present embodiment, its raw materials by weight portion meter, comprising: Radix Sophorae Flavescentis 100 parts, Cortex Dictamni 80 parts, Flos Lonicerae 50 parts, the Fructus Kochiae 50 parts, Herba Portulacae 35 parts, Cortex Phellodendri 30 parts, Rhizoma Acori Graminei 30 parts, Folium Artemisiae Argyi 35 parts, the Radix Angelicae Dahuricae 35 parts, Aloe 15 parts, Radix Angelicae Sinensis 15 parts, Borneolum Syntheticum 10 parts.
Its preparation method is:
(1) take above-mentioned Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Fructus Kochiae, Herba Portulacae, Cortex Phellodendri, Rhizoma Acori Graminei, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, decoct with water twice after mixing, first time adds 8 times of water yields, decocts 1.5 hours; Second time adds 6 times of water yields, decocts 1.0 hours, merges twice filtrate after filtering;
(2) take above-mentioned Aloe, add in the filtrate after step (1) merging, after concentrated, leave standstill 12 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take above-mentioned Borneolum Syntheticum, adopt the dissolve with ethanol of 95%, all join in the concentrated solution of step (2) gained, after mix homogeneously, be mixed with 1000ml, fill, packaging, to obtain final product.
Embodiment 4
The dermopathic Chinese medicine preparation of one control children's described in the present embodiment, its raw materials by weight portion meter, comprising: Radix Sophorae Flavescentis 70 parts, Cortex Dictamni 40 parts, Flos Lonicerae 20 parts, the Fructus Kochiae 20 parts, Herba Portulacae 10 parts, Cortex Phellodendri 10 parts, Rhizoma Acori Graminei 15 parts, Folium Artemisiae Argyi 15 parts, the Radix Angelicae Dahuricae 10 parts, Aloe 8 parts, Radix Angelicae Sinensis 8 parts, Borneolum Syntheticum 1.2 parts.
Its preparation method is:
(1) take above-mentioned Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Fructus Kochiae, Herba Portulacae, Cortex Phellodendri, Rhizoma Acori Graminei, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, decoct with water twice after mixing, first time adds 8 times of water yields, decocts 1.5 hours; Second time adds 6 times of water yields, decocts 1.0 hours, merges twice filtrate after filtering;
(2) take above-mentioned Aloe, add in the filtrate after step (1) merging, after concentrated, leave standstill 12 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take above-mentioned Borneolum Syntheticum, adopt the dissolve with ethanol of 95%, all join in the concentrated solution of step (2) gained, after mix homogeneously, be mixed with 1000ml, fill, packaging, to obtain final product.
Embodiment 5
The dermopathic Chinese medicine preparation of one control children's described in the present embodiment, its raw materials by weight portion meter, comprising: Radix Sophorae Flavescentis 90 parts, Cortex Dictamni 70 parts, Flos Lonicerae 40 parts, the Fructus Kochiae 40 parts, Herba Portulacae 25 parts, Cortex Phellodendri 25 parts, Rhizoma Acori Graminei 25 parts, Folium Artemisiae Argyi 30 parts, the Radix Angelicae Dahuricae 30 parts, Aloe 12 parts, Radix Angelicae Sinensis 12 parts, Borneolum Syntheticum 5 parts.
Its preparation method is:
(1) take above-mentioned Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, the Fructus Kochiae, Herba Portulacae, Cortex Phellodendri, Rhizoma Acori Graminei, Folium Artemisiae Argyi, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, decoct with water twice after mixing, first time adds 8 times of water yields, decocts 1.5 hours; Second time adds 6 times of water yields, decocts 1.0 hours, merges twice filtrate after filtering;
(2) take above-mentioned Aloe, add in the filtrate after step (1) merging, after concentrated, leave standstill 12 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take above-mentioned Borneolum Syntheticum, adopt the dissolve with ethanol of 95%, all join in the concentrated solution of step (2) gained, after mix homogeneously, be mixed with 1000ml, fill, packaging, to obtain final product.
Embodiment 6
One, antiinflammatory experiment (xylol of the present invention causes the Inhibition test of mice auricle swelling)
1, medicament: medicament described in embodiment 1 to embodiment 5; Commercially available fluocinonide cream.
2, animal: KM (Kunming kind) mice, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: the healthy mice 70 selecting body weight 18-22g, Quan Xiong, is divided into 7 groups at random by body weight, is specifically divided into positive controls, experimental group (1-5), commercially available matched group.By table 1 administration, often organize mouse right ear embrocate, each 0.1mL, every day 2 times, each 1 time of upper and lower noon, continuous 4 days, 30min after last coating, smear dimethylbenzene 50 μ L cause inflammation by often organizing mouse right ear, after causing scorching 50min, carry out test processes.
4, experimental result: calculate swelling and suppression ratio, the results are shown in Table 1.
Table 1 embodiment 6 xylol of the present invention causes the Inhibition test result of mice auricle swelling
Grouping | Number of animals (only) | Medicament | Swelling (mg) | Suppression ratio (%) |
Positive controls | 10 | Distilled water | 34.30±12.65 | — |
Experimental group 1 | 10 | Embodiment 1 | 14.80±6.76 | 56.85 |
Experimental group 2 | 10 | Embodiment 2 | 18.80±5.56 | 45.19 |
Experimental group 3 | 10 | Embodiment 3 | 18.60±7.70 | 45.77 |
Experimental group 4 | 10 | Embodiment 4 | 16.80±5.46 | 51.02 |
Experimental group 5 | 10 | Embodiment 5 | 19.80±6.55 | 42.27 |
Commercially available matched group | 10 | FUQINGSONG RUGAO | 9.20±1.70 | 73.18 |
As can be seen from the above table, experimental group 1-5 xylol causes mice auricle swelling and has good inhibition, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament FUQINGSONG RUGAO is hormones ointment, is according to patience therapeutant, child is used and has side effect, easily there is dependence facial dermatitis in life-time service, and the symptom such as local pigment calmness, hirsutism.And the application adopts pure Chinese medicinal components, there is no hormone, can not dependence be produced, be free from side effects.
Two, antiinflammatory experiment (the present invention causes the Inhibition test of rat paw edema to carrageenin)
1, medicament: medicament described in embodiment 1 to embodiment 5; Commercially available fluocinonide cream.
2, animal: SD rat, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: the healthy rat 70 selecting body weight 120-180g, Quan Xiong, is divided into 7 groups at random by body weight, is specifically divided into positive controls, experimental group (A-E), commercially available matched group.By table 2 administration, often organize the right sufficient sole of the foot embrocate of mice, each 0.1mL, every day 2 times, each 1 time of upper and lower noon, continuous 4 days, 30min after last coating, cause inflammation in Rat Right metapedes plantar aponeurosis hemostasis 1% carrageenin 0.05ml, adopt rat foot claw volume measuring apparatus to measure to cause scorching before and cause scorching after 1,2,4,6,8h rat's foot volume.
4, experimental result: calculate each time point rat paw edema rate, the results are shown in Table 2.
Table 2 embodiment 6 the present invention causes the Inhibition test result of rat paw edema to carrageenin
As can be seen from the above table, experimental group A-E causes rat paw edema to carrageenin and has good inhibition, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament FUQINGSONG RUGAO is hormones ointment, is according to patience therapeutant, child is used and has side effect, easily there is dependence facial dermatitis in life-time service, and the symptom such as local pigment calmness, hirsutism.And the application adopts pure Chinese medicinal components, there is no hormone, can not dependence be produced, be free from side effects.
Three, antiinflammatory experiment (xylol of the present invention causes the Inhibition test that mouse web portion capillary permeability increases)
1, medicament: medicament described in embodiment 1 to embodiment 5; Commercially available fluocinonide cream.
2, animal: KM (Kunming kind) mice, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: the healthy mice 70 selecting body weight 18-22g, Quan Xiong, is divided into 7 groups at random by body weight, is specifically divided into positive controls, experimental group (a-e), commercially available matched group.By table 3 administration, often organize embrocate on mouse web portion skin of unhairing, each 0.4ml/, every day 2 times, each 1 time of upper and lower noon, continuous 4 days, after last administration after 30min, through mouse tail vein injection 0.5% azovan blue normal saline solution 0.1ml/10gB.W., on position, mouse web portion skin of unhairing center, melted paraxylene 0.03ml/ is only immediately, carry out agent treated after 20min, within 3rd, measure A value (absorbance) afterwards.
4, experimental result: test A value and suppression ratio, the results are shown in Table 3.
Table 3 embodiment 6 xylol of the present invention causes the Inhibition test result that mouse web portion capillary permeability increases
Grouping | Number of animals (only) | Medicament | A value | Suppression ratio (%) |
Positive controls | 10 | Distilled water | 0.66±0.18 | — |
Experimental group a | 10 | Embodiment 1 | 0.27±0.09 | 59.09 |
Experimental group b | 10 | Embodiment 2 | 0.27±0.08 | 59.09 |
Experimental group c | 10 | Embodiment 3 | 0.39±0.09 | 40.90 |
Experimental group d | 10 | Embodiment 4 | 0.33±0.11 | 50.00 |
Experimental group e | 10 | Embodiment 5 | 0.29±0.08 | 56.06 |
Commercially available matched group | 10 | FUQINGSONG RUGAO | 0.15±0.03 | 77.27 |
As can be seen from the above table, experimental group a-e xylol causes the increase of mouse web portion capillary permeability and has good inhibition, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament FUQINGSONG RUGAO is hormones ointment, is according to patience therapeutant, child is used and has side effect, easily there is dependence facial dermatitis in life-time service, and the symptom such as local pigment calmness, hirsutism.And the application adopts pure Chinese medicinal components, there is no hormone, can not dependence be produced, be free from side effects.
Four, antiinflammatory experiment (the present invention causes the Inhibition test of mouse skin capillary permeability increase to histamine)
1, medicament: medicament described in embodiment 1 to embodiment 5; Commercially available cyproheptadine hydrochloride cream.
2, animal: SD rat, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: the healthy SD rat 70 selecting body weight 180-220g, Quan Xiong, is divided into 7 groups at random by body weight, is specifically divided into positive controls, experimental group (I-V), commercially available matched group.By table 3 administration, often organize rat at its unhairing back embrocate, each 0.4ml/, every day 2 times, each 1 time of upper and lower noon, continuous 4 days.30min after last administration, tail vein injection 1% azovan blue normal saline solution 0.4ml/10gB.W., immediately at back coating center position intradermal injection 0.1% histamine phosphate 0.1ml/ only, after 30min, carry out agent treated, within 3rd, measure A value (absorbance) afterwards.
4, experimental result: test A value and suppression ratio, the results are shown in Table 4.
Table 4 embodiment 6 the present invention causes the Inhibition test result of mouse skin capillary permeability increase to histamine
Grouping | Number of animals (only) | Medicament | A value | Suppression ratio (%) |
Positive controls | 10 | Distilled water | 0.48±0.11 | — |
Group I | 10 | Embodiment 1 | 0.20±0.08 | 58.33 |
Experimental group II | 10 | Embodiment 2 | 0.36±0.17 | 25.00 |
Experimental group III | 10 | Embodiment 3 | 0.23±0.10 | 52.08 |
Experimental group IV | 10 | Embodiment 4 | 0.28±0.11 | 41.67 |
Experimental group V | 10 | Embodiment 5 | 0.22±0.08 | 54.17 |
Commercially available matched group | 10 | Cyproheptadine hydrochloride cream | 0.14±0.03 | 70.83 |
As can be seen from the above table, group I-V pair histamine causes the increase of mouse skin capillary permeability and has good inhibition, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament cyproheptadine hydrochloride cream is hormones ointment, is according to patience therapeutant, child is used and has side effect, easily there is dependence facial dermatitis in life-time service, and the symptom such as local pigment calmness, hirsutism.And the application adopts pure Chinese medicinal components, there is no hormone, can not dependence be produced, be free from side effects.
Embodiment 7
Antipruritic experiment (the present invention causes the impact experiment of reaction of itching on histamine phosphate)
1, medicament: medicament described in embodiment 1 to embodiment 5; Commercially available cyproheptadine hydrochloride cream.
2, animal: Cavia porcellus (Britain's kind), is provided by plant of laboratory animal special commission of Sichuan Province.
3, experimental technique: the healthy guinea pig 70 selecting body weight 250-300g, male and female half and half, are divided into 7 groups at random by body weight, are specifically divided into positive controls, experimental group (1-5), commercially available matched group.By table 4 administration, before experiment, often organize the right back instep of Cavia porcellus and shave hair, area 1cm
2, every day embrocate 2 times, the upper and lower noon is each once, continuous 4 days, experiment shaved hair place when daily coarse sandpaper abrades right back instep, makes it rubescent, but with not hemorrhage for degree, local coating twice again, 1 hour, interval, 10min after last coating, start only to be coated with 0.01% histamine phosphate 50 μ L/ at wound surface, later every 3min is according to 0.02%, 0.03%, 0.04% progressive concentration, is only 50 μ L/ at every turn, until occur Cavia porcellus later lick right back sufficient time give histamine phosphate total amount be itch-threshold.The results are shown in Table 5.
Table 5 embodiment 7 the present invention on histamine phosphate cause itch reaction affect experimental result
Grouping | Number of animals (only) | Medicament | Itch-threshold (μ g) |
Positive controls | 10 | Distilled water | 0.13±0.09 |
Experimental group 1 | 10 | Embodiment 1 | 0.56±0.18 |
Experimental group 2 | 10 | Embodiment 2 | 0.31±0.43 |
Experimental group 3 | 10 | Embodiment 3 | 0.48±0.30 |
Experimental group 4 | 10 | Embodiment 4 | 0.50±0.28 |
Experimental group 5 | 10 | Embodiment 5 | 0.45±0.09 |
Commercially available matched group | 10 | Cyproheptadine hydrochloride cream | 0.71±0.40 |
As can be seen from the above table, experimental group 1-5 pairs of histamine phosphates cause itches in reaction, its itch-threshold is all higher, for commercially available matched group, although its itch-threshold is higher, commercially available matched group medicament cyproheptadine hydrochloride cream is hormones ointment, according to patience therapeutant, using child and have side effect, easily there is dependence facial dermatitis in life-time service, and the symptom such as local pigment calmness, hirsutism.And the application adopts pure Chinese medicinal components, there is no hormone, can not dependence be produced, be free from side effects.
Embodiment 8
Skin allergy is tested
1, medicament: medicament described in embodiment 1 to embodiment 5.
2, animal: Cavia porcellus (white Britain kind), is provided by plant of laboratory animal special commission of Sichuan Province.
3, experimental technique: the healthy guinea pig 70 selecting body weight 250-300g, male and female half and half, be divided into 7 groups at random by body weight, be specifically divided into positive controls (give 2,4-dinitro-chloro-benzene), experimental group (1-5) (giving preparation described in embodiment 1 to embodiment 5), negative control group (giving distilled water).Experiment proxima luce (prox. luc), (area is 3cm skin on the right side of guinea pig back to be shaved hair
2), test the same day, shave hair-fields daubing medicament 0.2mL on right side, then cover with one deck oilpaper and two-layer gauze, then with non-stimulated immobilization with adhesive tape, continue to wash away medicine in 6 hours, and observed the situations such as skin allergies in after this 24,48,72 hours.
4, calculate sensitization rate, experimental result is in table 6.
Table 6 embodiment 8 skin allergy experimental result
Embodiment 9
Repeatedly skin irritation test
1, medicament: medicament described in embodiment 1 to embodiment 5.
2, animal: rabbit, Japan large ear rabbit, male and female half and half, are provided by plant of laboratory animal special commission of Sichuan Province.
3, experimental technique: select healthy rabbits 15, be divided into 5 groups at random, be specifically divided into experimental group (1-5), adopt self left and right sides to contrast.With 8% sodium sulfide be in rabbit back depilation, each 3cm × 3cm of unhairing scope arranged on left and right sides.Check before administration that whether skin of unhairing is injured because of unhairing, injured skin should not be tested, next day is at depilation district, back daubing medicament, wherein left side skin distilled water compares, and right side gives preparation described in embodiment 1 to embodiment 5, once a day, continuous 14 days, smear rear 4h at every turn, wash away residue with warm water, to observe after drug withdrawal the situation that erythema and edema appear in 1,24,48,72 hour skin of back.
4, experimental result is in table 7.
Table 7 embodiment 9 skin irritation test result
Note: "None" is occur without erythema edema.
Below be only the preferred embodiment of the present invention, it should be pointed out that above-mentioned preferred implementation should not be considered as limitation of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For those skilled in the art, without departing from the spirit and scope of the present invention, can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. the dermopathic Chinese medicine preparation of control children's, it is characterized in that: the raw materials by weight portion meter of described preparation, comprising: Radix Sophorae Flavescentis 60-100 parts, Cortex Dictamni 30-80 parts, Flos Lonicerae 10-50 parts, the Fructus Kochiae 10-50 parts, Herba Portulacae 5-35 parts, Cortex Phellodendri 5-30 parts, Rhizoma Acori Graminei 5-30 parts, Folium Artemisiae Argyi 5-35 parts, the Radix Angelicae Dahuricae 5-35 parts.
2. the dermopathic Chinese medicine preparation of one control children's according to claim 1, it is characterized in that: the raw materials by weight portion meter of described preparation, comprising: Radix Sophorae Flavescentis 70-90 parts, Cortex Dictamni 40-70 parts, Flos Lonicerae 20-40 parts, the Fructus Kochiae 20-40 parts, Herba Portulacae 10-25 parts, Cortex Phellodendri 10-25 parts, Rhizoma Acori Graminei 15-25 parts, Folium Artemisiae Argyi 15-30 parts, the Radix Angelicae Dahuricae 10-30 parts.
3. the dermopathic Chinese medicine preparation of one control children's according to claim 2, it is characterized in that: the raw materials by weight portion meter of described preparation, comprising: Radix Sophorae Flavescentis 80 parts, Cortex Dictamni 60 parts, Flos Lonicerae 30 parts, the Fructus Kochiae 30 parts, Herba Portulacae 20 parts, Cortex Phellodendri 20 parts, Rhizoma Acori Graminei 20 parts, Folium Artemisiae Argyi 20 parts, the Radix Angelicae Dahuricae 20 parts.
4. the dermopathic Chinese medicine preparation of one control children's according to any one of claim 1-3, is characterized in that: the raw materials by weight portion meter of described preparation also comprises: Aloe 2-15 parts, Radix Angelicae Sinensis 1-15 parts, Borneolum Syntheticum 1-10 parts.
5. the dermopathic Chinese medicine preparation of one control children's according to claim 4, is characterized in that: mark is counted by weight: Aloe 8-12 parts, Radix Angelicae Sinensis 8-12 parts, Borneolum Syntheticum 4-6 parts.
6. the dermopathic Chinese medicine preparation of one control children's according to claim 5, is characterized in that: mark is counted by weight: Aloe 10 parts, Radix Angelicae Sinensis 10 parts, Borneolum Syntheticum 5 parts.
7. the dermopathic Chinese medicine preparation of one control children's according to any one of claim 1-6, is characterized in that: the dosage form of described preparation is washing liquid, also comprises pharmaceutically acceptable adjuvant in described preparation.
8. prevent and treat a preparation method for the dermopathic Chinese medicine preparation of children's, it is characterized in that: comprise the following steps:
(1) raw material of following parts by weight is taken: Radix Sophorae Flavescentis 60-100 parts, Cortex Dictamni 30-80 parts, Flos Lonicerae 10-50 parts, the Fructus Kochiae 10-50 parts, Herba Portulacae 5-35 parts, Cortex Phellodendri 5-30 parts, Rhizoma Acori Graminei 5-30 parts, Folium Artemisiae Argyi 5-35 parts, the Radix Angelicae Dahuricae 5-35 parts, Radix Angelicae Sinensis 1-15 parts, twice is decocted with water after mixing, first time adds 7-9 times of water yields, decocts 1-1.5 hours; Second time adds 5-8 times of water yields, decocts 0.5-1 hour, merges twice filtrate after filtering;
(2) take the Aloe that parts by weight are 2-15 parts, add in the filtrate after step (1) merging, after concentrated, leave standstill 10-15 hours, after adopting 200 mesh sieves to filter, obtain concentrated solution, for subsequent use;
(3) take the Borneolum Syntheticum that parts by weight are 1-10 parts, adopt the dissolve with ethanol of 95%, join in the concentrated solution of step (2) gained, after mix homogeneously and get final product.
9. preparation described in an any one of claim 1-6 is in preparation treatment children's dermatosis, the application strengthened on the medicine of children's's skin resistance against diseases.
10. application according to claim 9, is characterized in that: described children's's dermatosis is miliaria alba, urticaria, infantile eczema, diaper dermatitis, insect bite dermatitis.
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Cited By (5)
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CN107041860A (en) * | 2017-03-02 | 2017-08-15 | 广东省阳春市信德生物科技发展有限公司 | A kind of infant skin care cream |
CN108815435A (en) * | 2018-08-31 | 2018-11-16 | 陕西石宇药业有限公司 | A kind of preparation method of the Chinese medicine composition for treating pruritus dermatopathy and its preparation |
CN110051725A (en) * | 2019-04-22 | 2019-07-26 | 青岛市妇女儿童医院(青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心) | The externally-applied medicinal composition, preparation method and application method for treating newborn skin disease |
CN113425669A (en) * | 2021-08-19 | 2021-09-24 | 陈芳英 | Chinese herbal medicine bag for conditioning infantile eczema |
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CN101664497A (en) * | 2009-10-27 | 2010-03-10 | 张庆珍 | Pharmaceutical composition for treating pediatric dermatosis |
CN106176784A (en) * | 2016-07-18 | 2016-12-07 | 成都爱可依生物科技有限公司 | A kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof |
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CN1977916A (en) * | 2006-12-20 | 2007-06-13 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin disease |
CN101664497A (en) * | 2009-10-27 | 2010-03-10 | 张庆珍 | Pharmaceutical composition for treating pediatric dermatosis |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN107041860A (en) * | 2017-03-02 | 2017-08-15 | 广东省阳春市信德生物科技发展有限公司 | A kind of infant skin care cream |
CN108815435A (en) * | 2018-08-31 | 2018-11-16 | 陕西石宇药业有限公司 | A kind of preparation method of the Chinese medicine composition for treating pruritus dermatopathy and its preparation |
CN110051725A (en) * | 2019-04-22 | 2019-07-26 | 青岛市妇女儿童医院(青岛市妇幼保健院、青岛市残疾儿童医疗康复中心、青岛市新生儿疾病筛查中心) | The externally-applied medicinal composition, preparation method and application method for treating newborn skin disease |
CN113425669A (en) * | 2021-08-19 | 2021-09-24 | 陈芳英 | Chinese herbal medicine bag for conditioning infantile eczema |
CN115337345A (en) * | 2022-09-05 | 2022-11-15 | 河南科技大学 | Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites and preparation method thereof |
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