CN115337345A - Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites and preparation method thereof - Google Patents

Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites and preparation method thereof Download PDF

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CN115337345A
CN115337345A CN202211079871.8A CN202211079871A CN115337345A CN 115337345 A CN115337345 A CN 115337345A CN 202211079871 A CN202211079871 A CN 202211079871A CN 115337345 A CN115337345 A CN 115337345A
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flower
traditional chinese
taihang
chinese medicine
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吴正景
李建峰
武静静
安冰洁
刘素娟
张昊
职钤华
龙圆
李辰方
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Henan University of Science and Technology
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Abstract

The Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites is prepared from the following raw materials in parts by weight: 0.6-1.3 parts of taihang flower, 3-5 parts of radix sophorae flavescentis, 0.5-1.2 parts of cortex phellodendri, 0.7-1.5 parts of mung bean peel, 1-3 parts of towel gourd peel, 1-3 parts of mint, 1-3 parts of folium artemisiae argyi, 1-3 parts of fructus kochiae and 1-3 parts of cortex dictamni. The Taixing flower-based traditional Chinese medicine preparation disclosed by the invention has the formula principles of clearing away heat and toxic materials, inhibiting bacteria and killing bacteria, eliminating dampness and dispelling wind, killing parasites and relieving itching, diminishing inflammation and relieving pain, refreshing and restoring consciousness, and relieving skin, can realize quick itching relieving after being bitten by mosquitoes, has no toxic or side effect on a human body, is good in safety, convenient to use, has both internal and external treatment functions, and is suitable for infants.

Description

Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites and preparation method thereof
Technical Field
The invention belongs to the technical field of preparation of antipruritic traditional Chinese medicine preparations, and particularly relates to a taixing flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites and a preparation method thereof.
Background
When a person bites a mosquito, an anticoagulant is secreted, and the human immune system can release histamine under stress after the person feels the mosquito bites, so that the skin blood vessels and capillary vessels can be expanded, the permeability is increased, the small blood vessels are exuded, and redness is caused by congestion. Meanwhile, histamine may irritate skin nerve endings due to a large amount of histamine released from the bite site, resulting in allergic and inflammatory reactions, and a strong feeling of pain and itching. The manual grasping can promote the local release of more histamine, so that the pruritus is aggravated, and the skin is easily damaged by excessive force, thereby causing bacterial infection. The dermatitis caused by mosquito bite is called insect bite dermatitis, is a common disease in the dermatology department in summer, and takes local rash and skin pruritus as main clinical manifestations.
The western medicine clinical treatment aiming at the pruritus mostly adopts antihistamine, anti-inflammation and pain-relieving treatment, mostly adopts chemical compositions, contains local anesthetic drugs, antihistamine drugs, hormone drugs and the like, is easy to cause drug resistance of organisms, can cause damage to skin after long-term use, increases the burden of patients, and is not suitable for infants.
The traditional Chinese medicine considers that: dermatitis due to insect bite belongs to the syndrome of accumulated toxic heat, and is usually manifested as pruritus, red swelling and pain at the location of insect bite. If the pathogenic toxin is excessive and bleeding occurs after scratching, the toxic pathogen can invade the body, and the serious disease can be manifested as purple spots, even local pustules, general fever, etc. In summer and autumn, after the skin is bitten or pricked by insects or a poisonous thorn, insect poison enters the human body through gaps, and the poison is accumulated to transform into heat and generate dampness. Dampness-heat and insect poison stagnate in the skin, causing qi and blood stagnation between the skin. Therefore, for the syndrome of accumulated toxic heat caused by mosquito bites, the treatment should be mainly to clear heat and purge fire, detoxify and relieve swelling.
The taihang flower (taihang rupestris Yu et Li) was discovered in 1974 that the rose family single species plant identified in 1980 by shu dred and Liwang was a wild, perennial herbaceous plant and an ancient species of heritage. The Taihang flowers are distributed at the junction of Henan, hebei and Shanxi provinces at east China Taihang mountain, and the distribution area is narrow, so that the Taihang flowers have few residual quantities and belong to rare or endangered plants. The Taihang flower leaves are slightly bitter, astringent and flat, and can be used for treating the tinea, and the leaves contain flavonoids. Therefore, how to enrich the medicinal components in the taihang flower and compound the medicinal components with other traditional Chinese medicines to prepare the traditional Chinese medicine preparation which can realize rapid itching relieving after mosquito bites and has no toxic or side effect on human bodies is really necessary for the heat toxin accumulation syndrome caused by mosquito bites.
Disclosure of Invention
The technical purpose of the invention is as follows: the taixing flower-based traditional Chinese medicine preparation can realize rapid itching relieving after mosquito bites, has no toxic or side effect on human bodies, is good in safety and convenient to use, has the function of internal and external treatment, is suitable for infants, and is used for treating the heat toxin accumulation syndrome caused by mosquito bites.
The technical scheme adopted by the invention for realizing the purpose is as follows: the Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites is prepared from the following raw materials in parts by weight: 0.6-1.3 parts of taihang flower, 3-5 parts of radix sophorae flavescentis, 0.5-1.2 parts of cortex phellodendri, 0.7-1.5 parts of mung bean peel, 1-3 parts of towel gourd peel, 1-3 parts of mint, 1-3 parts of folium artemisiae argyi, 1-3 parts of fructus kochiae and 1-3 parts of cortex dictamni.
Preferably, the traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 1 part of Taihang flower, 3 parts of radix sophorae flavescentis, 1 part of cortex phellodendri, 1 part of mung bean peel, 2 parts of towel gourd peel, 2 parts of mint, 2 parts of folium artemisiae argyi, 2 parts of fructus kochiae and 1 part of cortex dictamni.
Preferably, the weight parts of the taihang flower, the golden cypress and the mung bean hull in the raw material formula of the traditional Chinese medicine preparation are the same.
Preferably, the taihang flower is a dried leaf of a fresh taihang flower plant.
The preparation method of the taixing flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites comprises the following steps:
taking radix sophorae flavescentis, mung bean peel and towel gourd peel as a raw material medicine a according to parts by weight, adding water with the mass being 10-15 times of that of the raw material medicine a into the raw material medicine a, soaking at room temperature for 30-60min, boiling and extracting for 1-1.5h, pouring out liquid medicine, adding water with the mass being 10-15 times of that of the raw material medicine into obtained medicine dregs, boiling and extracting for 1-1.5h again, combining liquid medicine obtained after two boiling and extracting, filtering, evaporating and concentrating obtained filtrate to 2-3 times of the mass of the raw material medicine a to obtain a traditional Chinese medicine a, and storing at 4 ℃ after cooling for later use;
step two, taking the taiwanhua and the golden cypress as a raw material medicine b respectively according to parts by weight, adding an ethanol solution with the mass being 2-4 times of that of the raw material medicine b into the raw material medicine b, soaking at room temperature for 12-24 hours, filtering, taking a filtrate, repeatedly extracting the obtained dregs of a decoction for 2 times by using the ethanol solution, combining the filtrates obtained by three times of extraction, and taking the filtrate as a traditional Chinese medicine preparation b for later use;
step three, respectively taking mint, folium artemisiae argyi, fructus kochiae and cortex dictamni as raw material medicines C according to parts by weight, adding an ethanol solution into the raw material medicines C to carry out reflux extraction for 3 times, wherein the amount of the ethanol solution added in each reflux extraction is 10-12 times of the amount of the materials to be extracted, the extraction time of each time is 2 hours, after each reflux extraction, carrying out centrifugal treatment on the obtained extracting solution for 10-20 minutes at the rotating speed of 2500-3500 r/min, taking supernate, combining the supernate obtained in three times, and carrying out vacuum concentration at the temperature of 50-60 ℃ until the mass of the raw material medicines is 2-3 times of that of the raw material medicines C to prepare a traditional Chinese medicine preparation C for later use;
and step four, mixing the traditional Chinese medicine preparation a prepared in the step one, the traditional Chinese medicine preparation b prepared in the step two and the traditional Chinese medicine preparation c prepared in the step three, sterilizing and packaging to obtain the finished product of the taixing flower-based traditional Chinese medicine preparation.
Preferably, in the second step, the mass concentration of the ethanol solution is 80%.
Preferably, in the third step, the mass concentration of the ethanol solution is 90%.
The invention has the beneficial effects that:
1. the invention relates to a taixing flower-based traditional Chinese medicine preparation, which takes the principles of clearing away heat and toxic material, inhibiting bacteria and killing bacteria, eliminating dampness and dispelling wind, killing parasites and relieving itching, diminishing inflammation and relieving pain, refreshing and restoring consciousness and relieving skin as the components, selects the itching-relieving type Chinese herbal medicines of radix sophorae flavescentis, golden cypress, mint, folium artemisiae argyi, fructus kochiae and cortex dictamni of a specific component formula to be compounded with taixing flower, mung bean peel and towel gourd peel to prepare the external-use type local spraying traditional Chinese medicine preparation. The Taixing flower-based traditional Chinese medicine preparation not only can quickly relieve itching and locally exert the treatment effects of relieving pain and itching, but also can deeply penetrate into viscera through the permeation of skin surface skin pores to achieve the internal conditioning functions of dredging channels and collaterals and regulating qi and blood, and has the functions of internal and external treatment.
2. The taixing flower-based traditional Chinese medicine preparation takes the taixing flower, the lightyellow sophora root, the dittany bark and the broom cypress fruit as monarch drugs and has the effects of detoxifying, relieving itching, killing insects, inhibiting bacteria, reducing swelling, removing stasis and the like; the golden cypress and the mung bean hull are used as ministerial drugs, and the golden cypress and the mung bean hull have the functions of removing stasis, removing rash, reducing swelling and lowering blood pressure; the mint and the folium artemisiae argyi are used as adjuvant drugs, and the effects of expelling parasites, restoring consciousness, relieving pain, eliminating evil and the like are achieved; the towel gourd peel is used as a guiding drug, and has the effects of harmonizing the drugs, clearing and activating the channels and collaterals, restoring the skin elasticity and the like. The medicines are compatible according to monarch, minister, assistant and guide medicines, and all the medicines have synergistic effect, thereby having better treatment effects of relieving itching and pain after mosquito bites and treating both internal and external diseases. Meanwhile, the traditional Chinese medicine formula has small toxic and side effects and good safety, is not easy to cause drug resistance of organisms, and is suitable for infants.
3. The Taixing flower-based traditional Chinese medicine preparation provided by the invention specifically selects nine traditional Chinese medicines as raw materials, the nine traditional Chinese medicines are scientifically matched, have mutual synergistic effect and complementary advantages, complement each other and fundamentally realize the treatment effects of quickly relieving itching, diminishing inflammation and removing swelling after mosquito bites internally and externally. The formula has the advantages of green and natural raw materials, no toxic or side effect, safety, reliability, aromatic smell, heart fire clearing and nerve soothing, and good practical effect.
Wherein: the taihang flower is rich in flavonoids, has the function of quickly relieving itching, has the function of stopping itching immediately after being used for treating pain and itching caused by mosquito bite, eczema and the like, has short itching relieving effect time, and needs to be matched with other itching relieving components to achieve the effect of eradicating and treating. The sophora flavescens has the effects of clearing heat, drying dampness, dispelling wind, removing toxicity, resisting inflammation, killing parasites, resisting allergy, relieving itching and the like, is mainly used for treating damp-heat dysentery, eczema, pruritus vulvae, dermatophytosis, malignant sore, eczema, skin pruritus and the like, has a good recovery effect on skin, and is used for treating eczema and scab. Cortex Phellodendri has effects of lowering blood pressure, resisting bacteria and inflammation, promoting wound healing and improving nonspecific immunity, and can be used for treating eczema and dermatitis. The cortex dictamni has obvious antiallergic and antiallergic effects, has treatment effect on acute and chronic skin allergy, can effectively inhibit the generation of allergic reaction by stabilizing hypertrophic cell membrane and reducing the release of inflammatory mediators such as histamine, and the like, plays an anti-inflammatory role, and has itching relieving effect. The fructus kochiae has remarkable antihistamine effect and good itching relieving effect, has the effects of clearing heat, promoting diuresis, relieving swelling and removing blood stasis, and is suitable for phlegm and blood stasis with heat syndrome. The external use of peppermint oil in peppermint can selectively stimulate cold receptors of nerve endings to generate cold feeling, and reflexively cause skin vasoconstriction to play the roles of diminishing inflammation, relieving pain and relieving itching, and the peppermint oil is clinically used for treating pruritic skin diseases and has the effect of expelling parasites. The folium Artemisiae Argyi has special odor, good parasite expelling effect, and effects of purifying air, inducing resuscitation, improving hearing and eyesight, improving memory, and preventing common cold. The luffa peel is prepared by airing the skin scraped by young luffa when being eaten, has the effects of clearing away heat and toxic materials, relieving swelling, promoting urination, clearing and activating the channels and collaterals, and has good relieving and treating effects on eczema, rubella, carbuncle sore pyogenic infections, urticaria and dermatitis; has antiallergic, antioxidant, free radical scavenging, skin elasticity improving, and skin caring effects; it also has immunity enhancing effect. The mung bean peel is obtained by soaking and swelling mung beans with water, kneading the obtained seed coat, and drying the residual peel shell of the germinated mung beans in the sun generally, and has the functions of eliminating macula and swelling.
Detailed Description
The technical scheme of the invention is further explained in detail by combining the specific embodiments as follows:
a Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites is prepared from the following raw materials in parts by weight: 0.6-1.3 parts of dried Taihang flower leaves, 3-5 parts of radix sophorae flavescentis, 0.5-1.2 parts of golden cypress, 0.7-1.5 parts of mung bean skins, 1-3 parts of towel gourd skins, 1-3 parts of mint, 1-3 parts of folium artemisiae argyi, 1-3 parts of fructus kochiae and 1-3 parts of cortex dictamni.
The preparation method of the Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites comprises the following steps:
taking radix sophorae flavescentis dry powder, mung bean peel and towel gourd peel as raw material medicines a, adding water with the mass being 10-15 times of that of the raw material medicines a into the raw material medicines a, soaking at room temperature for 30-60min, boiling and extracting for 1-1.5h, pouring out liquid medicine, adding water with the mass being 10-15 times of that of the raw material medicines into obtained dregs of a decoction, boiling and extracting for 1-1.5h again, combining the liquid medicine obtained after two boiling and extracting, filtering, evaporating and concentrating the obtained raw material medicines to 2-3 times of the mass of the raw material medicines to obtain a traditional Chinese medicine a, cooling, and storing at 4 ℃ for later use;
step two, taking the taihang flower and the golden cypress as a raw material medicine b respectively according to parts by weight, adding an ethanol solution with the mass concentration of 80% and the mass of 2-4 times of that of the raw material medicine b into the raw material medicine b, soaking at room temperature for 12-24 hours, filtering, taking a filtrate, repeatedly extracting the obtained dregs of a decoction for 2 times, and combining the filtrates obtained by three times of extraction to obtain a traditional Chinese medicine preparation b for later use;
step three, taking mint, folium artemisiae argyi, fructus kochiae and cortex dictamni as a raw material medicine C respectively according to parts by weight, adding an ethanol solution into the raw material medicine C for reflux extraction for 3 times, wherein the amount of the ethanol solution with the mass concentration of 90% added in each reflux extraction is 10-12 times of the mass of the material to be extracted, the extraction time of each time is 2 hours, after each reflux extraction, centrifuging the obtained extracting solution for 10-20 minutes at the rotating speed of 2500-3500 r/min, taking supernate, combining the supernate obtained in three times, and performing vacuum concentration at the temperature of 50-60 ℃ until the mass of the traditional Chinese medicine C is 2-3 times of the mass of the traditional Chinese medicine C to prepare the traditional Chinese medicine C for later use;
and step four, mixing the traditional Chinese medicine preparation a prepared in the step one, the traditional Chinese medicine preparation b prepared in the step two and the traditional Chinese medicine preparation c prepared in the step three, filtering to remove precipitates, sterilizing and subpackaging to obtain the finished product of the taihang Huaji traditional Chinese medicine preparation.
The taihang flower-based traditional Chinese medicine preparation for relieving itching after being bitten by mosquitoes is applied to the itching part when in use. The traditional Chinese medicine preparation has fragrant smell, clears away the heart fire, soothes the nerves, is coated once and can relieve itching instantly; can be used for many times to relieve itching and protect skin. For mosquito bite, eczema, etc., it can quickly relieve itching (itching feeling disappears within 1-several seconds after spraying), and has detumescence and antiphlogistic effects. For chronic diseases such as eczema, the aim of radical cure can be achieved by repeated use or combination of other medicines.
Example 1:
the taihang flower-based traditional Chinese medicine preparation for relieving itching after being bitten by mosquitoes is prepared from the following raw materials in parts by weight: 1 part of dried Taihang flower leaves, 3 parts of radix sophorae flavescentis, 1 part of golden cypress, 1 part of mung bean peel, 2 parts of towel gourd peel, 2 parts of mint, 2 parts of folium artemisiae argyi, 2 parts of fructus kochiae and 1 part of cortex dictamni.
The preparation method of the Taixing flower-based traditional Chinese medicine preparation comprises the following steps:
step one, taking lightyellow sophora root dry powder, mung bean peel and towel gourd peel according to the parts by weight, adding purified water with the mass being 10 times of that of the lightyellow sophora root dry powder, adding the purified water into the lightyellow sophora root dry powder, soaking the mixture at room temperature for 30 minutes, boiling the mixture for 1 hour, pouring out liquid medicine, repeatedly extracting the mixture for 1 time, mixing the liquid medicine poured out twice, filtering the mixture, evaporating and concentrating the mixture until the amount of the liquid medicine is 2 times of that of the original medicine to prepare a traditional Chinese medicine preparation a, and storing the traditional Chinese medicine preparation a at 4 ℃ for later use after cooling;
step two, taking the crassula argentea leaves and the golden cypress according to the parts by weight, soaking the crassula argentea leaves and the golden cypress for 12 hours by using 2 times of 80% ethanol solution at room temperature, filtering, repeating for 2 times, and taking filtrate obtained in three times as a traditional Chinese medicine preparation b for later use; standby;
step three, respectively taking mint, folium artemisiae argyi, fructus kochiae and cortex dictamni according to the weight parts, performing reflux extraction for 3 times by using 90% ethanol solution in an amount which is 10 times that of the mint, folium artemisiae argyi, fructus kochiae and cortex dictamni, performing centrifugation for 15min at 3000 r/min of an extracting solution for 2 hours each time, taking supernate, and performing vacuum concentration at 2 ℃ until the content of a raw medicine is 2 times that of the raw medicine to prepare a traditional Chinese medicine preparation C for later use;
and step four, mixing the traditional Chinese medicine preparation a prepared in the step one, the traditional Chinese medicine preparation b prepared in the step two and the traditional Chinese medicine preparation c prepared in the step three, sterilizing and packaging to obtain the finished product of the taixing flower-based traditional Chinese medicine preparation.
Example 2:
the taihang flower-based traditional Chinese medicine preparation for relieving itching after being bitten by mosquitoes is prepared from the following raw materials in parts by weight: 0.6 part of dried Taihang flower leaves, 5 parts of radix sophorae flavescentis, 1 part of golden cypress, 0.7 part of mung bean peel, 2 parts of towel gourd peel, 3 parts of mint, 1 part of folium artemisiae argyi, 1 part of fructus kochiae and 1 part of cortex dictamni.
The preparation method of the Taixing flower-based traditional Chinese medicine preparation comprises the following steps:
step one, taking the sophora flavescens dry powder, the mung bean peel and the towel gourd peel according to the parts by weight, adding purified water with the mass being 10 times of that of the sophora flavescens dry powder, the mung bean peel and the towel gourd peel, soaking for 40 minutes at room temperature, boiling for 1.2 hours, pouring out liquid medicine, repeatedly extracting for 1 time, mixing the liquid medicine poured out twice, filtering, evaporating and concentrating to 2 times of the original medicine to prepare a traditional Chinese medicine preparation a, and preserving at 4 ℃ for later use after cooling;
step two, taking the crassula argentea leaves and the golden cypress according to the parts by weight, soaking the crassula argentea leaves and the golden cypress for 12 hours by using 3 times of 80% ethanol solution at room temperature, filtering, repeating for 2 times, and taking filtrate obtained in three times as a traditional Chinese medicine preparation b for later use; standby;
step three, respectively taking the mint, the folium artemisiae argyi, the fructus kochiae and the cortex dictamni according to the parts by weight, carrying out reflux extraction for 3 times by using 90% ethanol solution in an amount which is 12 times that of the mint, the folium artemisiae argyi, the fructus kochiae and the cortex dictamni, carrying out centrifugation for 20min at 3000 r/min of an extracting solution, taking supernate, and carrying out vacuum concentration at 0 ℃ until the amount of a raw medicine is 3 times that of the extracting solution, so as to prepare a traditional Chinese medicine preparation C for later use;
and step four, mixing the traditional Chinese medicine preparation a prepared in the step one, the traditional Chinese medicine preparation b prepared in the step two and the traditional Chinese medicine preparation c prepared in the step three, sterilizing and packaging to obtain the finished product of the taixing flower-based traditional Chinese medicine preparation.
Example 3:
the taihang flower-based traditional Chinese medicine preparation for relieving itching after being bitten by mosquitoes is prepared from the following raw materials in parts by weight: 1.3 parts of dried Taihang flower leaves, 4 parts of radix sophorae flavescentis, 0.5 part of golden cypress, 1.5 parts of mung bean peel, 3 parts of towel gourd peel, 2 parts of mint, 2 parts of folium artemisiae argyi, 2 parts of fructus kochiae and 2 parts of cortex dictamni.
The preparation method of the Taixing flower-based traditional Chinese medicine preparation comprises the following steps:
step one, taking the sophora flavescens dry powder, the mung bean peel and the towel gourd peel according to the parts by weight, adding purified water with the mass being 12 times of that of the sophora flavescens dry powder, the mung bean peel and the towel gourd peel, soaking for 50 minutes at room temperature, boiling for 1.1 hour, pouring out liquid medicine, repeatedly extracting for 1 time, mixing the liquid medicine poured out twice, filtering, evaporating and concentrating to be 3 times of the original medicine to prepare a traditional Chinese medicine preparation a, and preserving at 4 ℃ for later use after cooling;
step two, taking the crassula argentea leaves and the golden cypress according to the parts by weight, soaking the crassula argentea leaves and the golden cypress for 15 hours by using 3 times of 80% ethanol solution at room temperature, filtering, repeating for 2 times, and taking filtrate obtained in three times as a traditional Chinese medicine preparation b for later use; standby;
step three, respectively taking mint, folium artemisiae argyi, fructus kochiae and cortex dictamni according to the parts by weight, carrying out reflux extraction for 3 times by using 90% ethanol solution in an amount which is 11 times that of the mint, folium artemisiae argyi, fructus kochiae and cortex dictamni, carrying out centrifugation for 10min at 3500 r/min of the extracting solution, taking supernate, and carrying out vacuum concentration at 1 ℃ until the content of the original medicine is 2.5 times that of the original medicine to prepare a traditional Chinese medicine preparation C for later use;
and step four, mixing the Chinese medicinal preparation a prepared in the step one, the Chinese medicinal preparation b prepared in the step two and the Chinese medicinal preparation c prepared in the step three, sterilizing and packaging to obtain the finished product of the taixing flower-based Chinese medicinal preparation.
Example 4:
the taihang flower-based traditional Chinese medicine preparation for relieving itching after being bitten by mosquitoes is prepared from the following raw materials in parts by weight: 1 part of dried Taihang flower leaves, 5 parts of radix sophorae flavescentis, 1.2 parts of golden cypress, 1.2 parts of mung bean peel, 1 part of towel gourd peel, 1 part of mint, 3 parts of folium artemisiae argyi, 1 part of fructus kochiae and 3 parts of cortex dictamni.
The preparation method of the Taixing flower-based traditional Chinese medicine preparation comprises the following steps:
step one, taking the sophora flavescens dry powder, the mung bean peel and the towel gourd peel according to the parts by weight, adding purified water with the mass being 15 times of that of the sophora flavescens dry powder, the mung bean peel and the towel gourd peel, soaking for 60 minutes at room temperature, boiling for 1.5 hours, pouring out liquid medicine, repeatedly extracting for 1 time, mixing the liquid medicine poured out twice, filtering, evaporating and concentrating to 2.2 times of the original medicine to prepare a traditional Chinese medicine preparation a, and preserving at 4 ℃ for later use after cooling;
step two, taking the Taihang flower leaves and the golden cypress according to the parts by weight, soaking the Taihang flower leaves and the golden cypress for 24 hours at room temperature by using 4 times of 80% ethanol solution, filtering, repeating the step 2 times, and taking filtrate obtained in three times as a traditional Chinese medicine preparation b for later use; standby;
step three, respectively taking mint, folium artemisiae argyi, fructus kochiae and cortex dictamni according to the weight parts, performing reflux extraction for 3 times by using 90% ethanol solution in an amount which is 10 times that of the mint, folium artemisiae argyi, fructus kochiae and cortex dictamni, performing centrifugation for 20min at 2500 r/min for each time, taking supernate, and performing vacuum concentration at 4 ℃ until the content of a raw medicine is 2 times that of the raw medicine to prepare a traditional Chinese medicine preparation C for later use;
and step four, mixing the traditional Chinese medicine preparation a prepared in the step one, the traditional Chinese medicine preparation b prepared in the step two and the traditional Chinese medicine preparation c prepared in the step three, sterilizing and packaging to obtain the finished product of the taixing flower-based traditional Chinese medicine preparation.
Clinical trial
In order to better verify the curative effect of the invention, clinical observation and experimental study is carried out on the taihang flower-based traditional Chinese medicine preparation prepared in the embodiment 1 of the invention to further illustrate the curative effect of the invention on relieving and treating mosquito bites.
And (3) clinical trials:
1. the taixing flower-based traditional Chinese medicine preparation (which is a spray and is sprayed on an affected part) prepared in the embodiment 1 of the invention is adopted to carry out clinical tests on 153 mosquito bites in sequence, and 317 swelling bags or red and itchy parts are sprayed. Wherein, within 5 seconds after 311 cases of spraying, the itch and pain feel disappears; in 6 cases, the itching and pain feeling is weakened within 5 seconds due to the fact that the swelling bag is too large (larger than the size of the nail cover of an adult), and the itching and pain feeling disappears completely after 10min, and the swelling bag disappears.
2. The taixing flower-based traditional Chinese medicine preparation prepared in the embodiment 1 of the invention is a spray and is sprayed on an affected part for use, 125 eczema patients are subjected to clinical itching relieving tests in sequence, the use method is that the taixing flower-based traditional Chinese medicine preparation is sprayed on the eczema part until the surface of the skin is completely wetted, the taixing flower-based traditional Chinese medicine preparation is continuously used for 1-3 days according to the specific conditions of the affected part, and the spraying is carried out for 3-4 times every day.
Among them, the itching and pain of 118 patients disappear within 10 seconds after the first spraying; 7 patients have weakened itching after spraying; after 87 patients use the eczema ointment for 1 day, red and swollen particles on the affected part of the eczema disappear, and the skin returns to a normal state; after 31 patients continuously use the ointment for 2 days, the red and swollen particles on the affected part of the eczema completely disappear, and the skin returns to a normal state; after 5 patients continuously use the ointment for 3 days, the red and swollen particles on the affected part of the eczema completely disappear, and the skin returns to a normal state; because of the long time and large area of eczema, 2 patients can slowly recover the affected part of eczema after continuous use for 5-10 days. But the spraying radical cure rate of the eczema is only 64.8 percent.
From the results of the above clinical trial studies, it can be seen that: the Taihang flower-based traditional Chinese medicine preparation has 100 percent of treatment and alleviation effects on mosquito bites and eczema.

Claims (7)

1. The taihang flower-based traditional Chinese medicine preparation for relieving itching after being bitten by mosquitoes is characterized by being prepared from the following raw materials in parts by weight: 0.6-1.3 parts of taihang flower, 3-5 parts of radix sophorae flavescentis, 0.5-1.2 parts of cortex phellodendri, 0.7-1.5 parts of mung bean peel, 1-3 parts of towel gourd peel, 1-3 parts of mint, 1-3 parts of folium artemisiae argyi, 1-3 parts of fructus kochiae and 1-3 parts of cortex dictamni.
2. The taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 1 part of Taihang flower, 3 parts of radix sophorae flavescentis, 1 part of cortex phellodendri, 1 part of mung bean peel, 2 parts of towel gourd peel, 2 parts of mint, 2 parts of folium artemisiae argyi, 2 parts of fructus kochiae and 1 part of cortex dictamni.
3. The taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites as claimed in claim 1, which is characterized in that: the raw material formulas of the traditional Chinese medicine preparation comprise the same components in parts by weight of the Taihang flower, the golden cypress and the mung bean hull.
4. The taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites as claimed in claim 1, 2 or 3, wherein: the Taihang flowers are dried leaves of fresh Taihang flower plants.
5. The method for preparing the taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites as claimed in any one of claims 1 to 3, which comprises the following steps:
firstly, taking radix sophorae flavescentis, mung bean peel and towel gourd peel as a raw material medicine a respectively according to parts by weight, adding water with the mass being 10-15 times of that of the raw material medicine a into the raw material medicine a, soaking at room temperature for 30-60min, boiling and extracting for 1-1.5h, pouring out liquid medicine, adding water with the mass being 10-15 times of that of the raw material medicine into obtained medicine dregs, boiling and extracting for 1-1.5h again, combining liquid medicine obtained after two boiling and extracting, filtering, evaporating and concentrating obtained filtrate to 2-3 times of the mass of the raw material medicine a to prepare a traditional Chinese medicine a, and storing at 4 ℃ after cooling for later use;
step two, taking the taihang flower and the golden cypress respectively as a raw material medicine b according to parts by weight, adding an ethanol solution with the mass being 2-4 times of that of the raw material medicine b into the raw material medicine b, soaking at room temperature for 12-24 hours, filtering, taking a filtrate, repeatedly extracting the obtained dregs of a decoction for 2 times by using the ethanol solution, and combining the filtrates obtained by three times of extraction to obtain a traditional Chinese medicine preparation b for later use;
step three, taking mint, folium artemisiae argyi, fructus kochiae and cortex dictamni as a raw material medicine C respectively according to parts by weight, adding an ethanol solution into the raw material medicine C to carry out reflux extraction for 3 times, wherein the amount of the ethanol solution added in each reflux extraction is 10-12 times of the amount of the substance to be extracted, the extraction time of each time is 2 hours, after each reflux extraction, carrying out centrifugal treatment on the obtained extracting solution for 10-20 minutes at the rotating speed of 2500-3500 r/min, taking supernate, combining the supernate obtained in three times, and carrying out vacuum concentration at the temperature of 50-60 ℃ until the mass of the raw material medicine C is 2-3 times of that of the raw material medicine C to prepare a traditional Chinese medicine C for later use;
and step four, mixing the Chinese medicinal preparation a prepared in the step one, the Chinese medicinal preparation b prepared in the step two and the Chinese medicinal preparation c prepared in the step three, sterilizing and packaging to obtain the finished product of the taixing flower-based Chinese medicinal preparation.
6. The method for preparing the taixing flower-based Chinese medicinal preparation for relieving itching after mosquito bites as claimed in claim 5, wherein the preparation method comprises the following steps: in the second step, the mass concentration of the ethanol solution is 80%.
7. The method for preparing the taihang flower-based Chinese medicinal preparation for relieving itching after mosquito bites as claimed in claim 5, wherein the method comprises the following steps: in the third step, the mass concentration of the ethanol solution is 90%.
CN202211079871.8A 2022-09-05 2022-09-05 Taihang flower-based traditional Chinese medicine preparation for relieving itching after mosquito bites and preparation method thereof Pending CN115337345A (en)

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CN102861271A (en) * 2012-10-09 2013-01-09 中国人民解放军第四军医大学 External-use inflammation-diminishing itching-relieving ointment preparation and preparation method thereof
CN105497353A (en) * 2015-12-25 2016-04-20 成都爱可依生物科技有限公司 Chinese herbal preparation for preventing and controlling children dermatosis and preparing method and application thereof
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CN102861271A (en) * 2012-10-09 2013-01-09 中国人民解放军第四军医大学 External-use inflammation-diminishing itching-relieving ointment preparation and preparation method thereof
CN105497353A (en) * 2015-12-25 2016-04-20 成都爱可依生物科技有限公司 Chinese herbal preparation for preventing and controlling children dermatosis and preparing method and application thereof
CN108888676A (en) * 2018-09-04 2018-11-27 柳州市妇幼保健院 A kind of Chinese medicine composition and preparation method thereof for treating eczema

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