CN101095799B - Liquor preparations for removing dandruff and method for preparing the same - Google Patents
Liquor preparations for removing dandruff and method for preparing the same Download PDFInfo
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- CN101095799B CN101095799B CN200610045260A CN200610045260A CN101095799B CN 101095799 B CN101095799 B CN 101095799B CN 200610045260 A CN200610045260 A CN 200610045260A CN 200610045260 A CN200610045260 A CN 200610045260A CN 101095799 B CN101095799 B CN 101095799B
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Abstract
The invention discloses a solution for removing dandruff and its preparing process, wherein the solution is prepared from rhubarb horsetails, flavescent sophora root, Chinese dittany bark, poria cocos, rough gentian, boneol, menthol, ketoconazole, Clobetasol Propionate, propylene glycol, glycerin, azone, polysorbate -80 and sodium benzoate through charging the first five Chinese herbs into water, boiling, concentrating the filtrate, charging ketoconazole, Clobetasol Propionate, boneol, menthol and auxiliary materials, finally keeping constant volume by charging ethanol.
Description
1, technical field
The present invention relates to a kind of liquor preparations for removing dandruff and preparation method thereof, mainly be that Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Cortex Dictamni, Rhizoma Smilacis Glabrae, Radix Gentianae, Borneolum Syntheticum, Mentholum, ketoconazole, clobetasol propionate with certain part by weight is raw material, propylene glycol, glycerol, azone, Tween-80, sodium benzoate with certain part by weight are adjuvant, decoct with water, filter preceding Chinese medicine of the five flavours concentrated, add ketoconazole, clobetasol propionate, Borneolum Syntheticum, Mentholum and adjuvant again, and add the ethanol standardize solution, be prepared from; Belong to medical technical field.
2, background technology
The dandruff is a kind of common situation, can be caused by several factors.It is relevant with endocrine regulation, gastrointestinal dysfunction, physicochemical irritation and infected by microbes that doctor trained in Western medicine is thought, hypersteatosis, parasitical fungi is (as sugared rash tinea Pseudomonas, propionibacterium, staphylococcus, Epidermophyton and Candida easily, wherein main relevant) with oval pityrosporum furfur raised growth in the sebum capsule, and cause that surperficial free fatty increases, thereby cause that the dandruff increases, scalp itch, cause the patient stimulate, poverty-stricken and worried.The traditional Chinese medical science then is referred to as " seborrheic dermatitis " or " seborrhea ichthyosis ", all because of " heat in blood endogenous dampness, wet strong being harmonious, contamination is not healed, and steep and lose skin, and all skin ulcers is given birth to " (" all infections introductions of Yangke Xinde Ji, Experience Gained in Treating External Diseases opinion ").All there is health problem to some extent in the adult scalp of China more than 60%, and the dandruff is modal scalp health problem, but owing to having ignored the skin of head health care, not cultivated good health habits, a lot of people enjoy the dandruff puzzlement.In view of above situation, the treatment dandruff has become the problem of a lot of investigations and the target of treatment.
Numerous in the market dandruff-controlling shampoos is by adding anti-dandruff dose of purpose that reaches removing scurf and relieving itching, but anti-dandruff dose that uses mostly is anti-dandruff dose of chemosynthesis greatly, mainly contain three kinds: ZPT (being organic zinc salt), Octopirox (a kind of Pyridione derivatives) and CLM (anti-dandruff dose of imidazoles agent, be commonly called as climbazole), but these synthetics all have shortcoming separately.
Radix Et Rhizoma Rhei is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..Cold in nature, bitter in the mouth is returned spleen, stomach, large intestine, liver, pericardium channel.Mainly contain anthraquinone derivatives such as chrysophanic acid, emodin, chrysophanol, aloe-emodin, physcione in the Radix Et Rhizoma Rhei, have the broad-spectrum antibacterial effect, G
+And G
-Bacterium all has inhibitory action, and it is synthetic to suppress antibacterial carbohydrate metabolism and protein and nucleic acid; Other antibacterials there is synergistic function.
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Cold in nature, bitter in the mouth, GUIXIN, liver, stomach, large intestine, urinary bladder channel.Mainly contain multiple alkaloids such as matrine, oxymatrine, sophor-anol, N-Methylcytisine in the Radix Sophorae Flavescentis, has the drug effect that suppresses anaphylaxis, kills and suppress body surface various bacteria and conk, external can sterilization, antiinflammatory, antipruritic, and effect is remarkable.
Cortex Dictamni is the dry root bark of rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..Cold in nature, bitter in the mouth is returned spleen, stomach, urinary bladder channel.Contain dictamine, shaggy-fruited dittany brain lactone etc. in the Cortex Dictamni, have heat clearing and damp drying, dispelling wind for relieving itching and bacteriostasis antibiosis effect.
Rhizoma Smilacis Glabrae is the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Property is put down, and sweet in the mouth, light is returned liver, stomach warp.Contain Saponin, tannin, resin etc. in the Rhizoma Smilacis Glabrae, have the effect of detoxifcation, dehumidifying.
Radix Gentianae is the dry root and rhizome of gentianaceae plant bar leaf Radix Gentianae Gentiana manshurica Kitag., Radix Gentianae Gentiana scabra Bge., three flower Radix Gentianae Gentianatriflora pall. or Gentiana rigescens Franch Gentiana rigescens Franch.. cold in nature, bitter in the mouth, return liver, gallbladder meridian. mainly contain gentiopicrin, erythricine etc. in the Radix Gentianae, have the function of heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.
Borneolum Syntheticum is synthetic water white transparency or the crisp crystallization of white translucent lamellar.Cold nature, acrid in the mouth, hardship, GUIXIN, spleen, lung meridian.Has the refreshment of having one's ideas straightened out, the function of clearing away heat to alleviate pain.Natural Broneolum Syntheticum be the fresh branch, leaf of canella Camphor tree Cinnamomum camphora (L.) Sieb. through water vapour distillation, distillation and the crystallization that makes.Cool in nature, acrid in the mouth, hardship.The function that have logical all keys, the stagnated fire of loosing, reducing swelling and alleviating pain, removing nebula makes eye bright.
Mentholum is a kind of saturated cyclic alcohol that obtains in the Oleum menthae.Oleum menthae is fresh stem and the Ye Jing vapor distillation of labiate Herba Menthae Mentha haplocalyx Briq., and is freezing again, and part is taken off the volatile oil that brain processing obtains.Herba Menthae is the dry aerial parts of labiate Herba Menthae Menthahaplocalyx Briq..Cool in nature, acrid in the mouth is returned lung, Liver Channel.Function with dispelling wind-heat.
Ketoconazole is synthetic imidazoles two alkane derivatives, has antibacterial and bactericidal activity to dermatophytes, yeast (Candida, Pityrosporum, Torulopsis, Cryptococcus), two-phase fungus and Mycophytes.By suppressing fungus ergosterol biosynthesis and change the composition of other lipoid substance of cell membrane, thereby reach antibacterial and germ-resistant purpose.
Clobetasol propionate is a kind of potent external 17-hydroxy-11-dehydrocorticosterone, has very strong antiinflammatory action and resisting mitosis effect.Fat-soluble strong, better to the osmosis of skin, it is longer to hold time.External mainly absorbs by hair follicle sebum and epidermis.Be applicable to chronic eczema, psoriasis, lichen planus, discoid lupus erythematosus, neurodermatitis, the effective dermatosis of palmoplantar pustulosis isocortex steroid external curing.
3, summary of the invention
At dandruff incidence rate height, and the present situation that does not have the medicinal shampoo of very suitable removing scurf and relieving itching in order to remove dandruff patient's misery, is improved the quality of living, and the invention provides a kind of new external liquor preparations for removing dandruff and preparation method thereof.
Solution of the present invention adopts the prescription of Chinese medicine chemical addition, has avoided simple use Chinese medicine DeGrain and has used the shortcoming of chemicals to the toxic effect of human body merely; Each drug synergism has favorable effects to dandruff, stopping head itching, can regulate sebum secretion, remove fungus, eliminate the reason that produces the dandruff, alleviate stimulation simultaneously scalp, enhancing immunity helps to prevent the regeneration of the dandruff to a certain extent; To human body safety, do not hinder hair, reach dandruff effect safely and effectively.
Solution of the present invention mainly is to be made by following bulk drugs and adjuvant:
Radix Et Rhizoma Rhei 150～250g Radix Sophorae Flavescentis 150～250g Cortex Dictamni 150～250g
Rhizoma Smilacis Glabrae 150～250g Radix Gentianae 150～250g Borneolum Syntheticum 15～25g
Mentholum 1～10g ketoconazole 15～25g clobetasol propionate 0.1～1.0g
Propylene glycol 20～100ml glycerol 20～100ml azone 10～30ml
Tween-80 50～150ml sodium benzoate 1～10g.
Solution of the present invention, optimum weight part of primary raw material medicine and adjuvant is:
Radix Et Rhizoma Rhei 200g Radix Sophorae Flavescentis 200g Cortex Dictamni 200g
Rhizoma Smilacis Glabrae 200g Radix Gentianae 200g Borneolum Syntheticum 20g
Mentholum 5g ketoconazole 20g clobetasol propionate 0.5g
Propylene glycol 50ml glycerol 50ml azone 20ml
Tween-80 80ml sodium benzoate 5g.
In the solution of the present invention, the Chinese medicine of selecting for use is Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis, Cortex Dictamni, Rhizoma Smilacis Glabrae, Radix Gentianae, Borneolum Syntheticum, Mentholum, based on clearing heat and expelling damp, invigorate blood circulation antipruritic.The Radix Sophorae Flavescentis heat clearing and damp drying is antipruritic, is good at " controlling the Cuo furuncle has an itch "; Radix Et Rhizoma Rhei can be gone into blood system, is apt to removing heat from blood, invigorates blood circulation, and makes " the blood sector-style is from going out ", and two medicines are monarch drug altogether.Cortex Dictamni has heat clearing and damp drying, the effect of dispelling wind for relieving itching; The detoxifcation of Rhizoma Smilacis Glabrae clearing away heat-damp and promoting diuresis is usually used in carbuncle sore, especially repeatedly Fa Zuo chronic skin infection, eczema; Radix Gentianae eliminating pathogen in the liver gallbladder excess-fire, the kind merit of removing the damp and hot diuresis of holding concurrently again, three medicines are ministerial drug altogether.Mentholum, the hot perfume (or spice) of Borneolum Syntheticum are walked to scurry, and go into through walking network, and inducting the medicines into affected channel, two medicines are adjuvant altogether.
In order to increase the antibacterial and itching-relieving action of solution of the present invention, chemicals ketoconazole and clobetasol propionate have also been selected for use.Complement each other with above-mentioned Chinese medicine, synergism, thus can effectively remove the dandruff, stopping head itching, can regulate sebum secretion, remove fungus, eliminate the reason that produces the dandruff; And non-stimulated to scalp, do not hinder hair, safety index is higher; Contain the multiple nutrients material in the Chinese medicine, at all right nutrition scalp of germ-resistant while, enhancing immunity helps to prevent the regeneration of the dandruff to a certain extent, thereby reaches persistent removing scurf and relieving itching effect.
The preparation method of solution of the present invention may further comprise the steps:
Radix Et Rhizoma Rhei, Cortex Dictamni, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, the Radix Gentianae of getting recipe quantity decoct with water, and filter, and filtrate concentrates, and adds ethanol, and cold preservation filters, and filtrate recycling ethanol does not extremely have the alcohol flavor, adds ethanol, add sodium benzoate and stir, and get solution A; It is complete that the ketoconazole of getting recipe quantity adds diluted hydrochloric acid dissolution, adds Tween-80, propylene glycol, glycerol, azone, stir, solution B; Solution A is joined in the solution B, get solution C; Mentholum, Borneolum Syntheticum, the clobetasol propionate of getting recipe quantity add dissolve with ethanol, add Tween-80 and stir, and get solution D; Solution D is joined in the solution C, stir, add ethanol and adjust total amount, stir; Transfer the solution pH value, filter, sterilization, fill, promptly.
Solution optimum weight part raw material of the present invention and adjuvant are made the preparation method of 1000ml, may further comprise the steps:
Radix Et Rhizoma Rhei 200g, Radix Sophorae Flavescentis 200g, Cortex Dictamni 200g, Rhizoma Smilacis Glabrae 200g, Radix Gentianae 200g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, filtrate is concentrated into relative density 1.12～1.14 (60 ℃), adding ethanol makes the alcohol amount to 60%, cold preservation 24 hours filters, and filtrate recycling ethanol is to there not being the alcohol flavor, adding ethanol makes the alcohol amount to 20%, add sodium benzoate 5g, stir, get solution A; Ketoconazole 20g adds 11.7% dilute hydrochloric acid 50ml dissolving fully, adds Tween-80 50ml, propylene glycol 50ml, glycerol 50ml, azone 20ml, stir, solution B; Solution A is joined in the solution B, get solution C; Mentholum 5g, Borneolum Syntheticum 20g, clobetasol propionate 0.5g add the 30ml dissolve with ethanol, add Tween-80 30ml and stir, and get solution D; Solution D is joined in the solution C, stir, get settled solution, add 20% ethanol and adjust total amount, stir to 1000ml; Transferring the solution pH value is 4.0～5.0, filter, and sterilization, fill, promptly.
Below further set forth the beneficial effect of solution of the present invention by testing example, but this should be interpreted as that solution of the present invention only has following beneficial effect.Below the solutions employed agent is embodiment 1 a preparation gained in the test.
The comparison of the effect of test example 1, solution of the present invention and commercially available anti-dandruff solution
Be subjected to test product: solution of the present invention (self-control is referring to embodiment 1)
Commercially available a kind of anti-dandruff solution that contains ketoconazole (trade name: adopt pleasure, commercial)
Test method: test is carried out at least 1/4 zone of both sides scalp being tested to medium serious dandruff patient to the order of severity, and the clear water through two weeks before the test washs.During the processing in 6 weeks, participate in the experimenter and in the stated day, have one's hair wash with solution of the present invention, wash weekly 3 times.The scoring of the dandruff and pruritus degree is carried out in back two days of last hair washing respectively to 1/4 zone of each scalp.Standards of grading: dandruff 0=does not have, and 1=is slight, the 2=moderate, and 3=is heavier, and 4=is serious; Pruritus 0=does not itch, and 1=is little to itch, and 2=itches, and 3=itches and can stand very much, and 4=very itches and is difficult to stand.Estimate all backs relapse rate simultaneously.
Result of the test: test is analyzed 30 experimenters' result of the test. and 6 weeks through solution of the present invention are handled after date, the scoring of the average dandruff reduces to 0.43 (alleviating 88.5%) by 3.75, average pruritus scoring reduces to 0.25 (alleviating 93.2%) by 3.67, and relapse rate is 7.2% after the week; Reduce to 1.45 (alleviating 60.8%) and adopt happy hair washing group dandruff scoring by 3.70, the pruritus scoring reduces to 1.12 (alleviating 69.9%) by 3.72, and relapse rate is 18.4%. after the week
Conclusion: result of the test shows, solution dandruff of the present invention, antipruritic and prevent from the effect that recurs obviously to be better than adopting pleasure.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following examples.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.The adjuvant of each dosage form can be replaced with acceptable accessories in following examples, perhaps reduces, increases.
The preparation of embodiment 1, solution of the present invention
Prescription:
Radix Et Rhizoma Rhei 200g Radix Sophorae Flavescentis 200g Cortex Dictamni 200g
Rhizoma Smilacis Glabrae 200g Radix Gentianae 200g Borneolum Syntheticum 20g
Mentholum 5g ketoconazole 20g clobetasol propionate 0.5g
Propylene glycol 50ml glycerol 50ml azone 20ml
Tween-80 80ml sodium benzoate 5g
Make 1000ml
Preparation technology:
Radix Et Rhizoma Rhei, Cortex Dictamni, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, the Radix Gentianae of getting recipe quantity decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, it is 1.12～1.14 (60 ℃) that filtrate is concentrated into relative density, add ethanol and make the alcoholic acid amount to 60% that contains, cold preservation 24 hours filters filtrate for later use, reclaim ethanol to there not being the alcohol flavor, add ethanol and make the alcohol amount, add sodium benzoate 5g, stir to 20%.Ketoconazole adds 11.7% dilute hydrochloric acid 50ml dissolving fully, adds Tween-80 50ml, propylene glycol 50ml, glycerol 50ml, azone 20ml, stirs, and merges with above-mentioned solution.Mentholum, Borneolum Syntheticum, clobetasol propionate add the 30ml dissolve with ethanol, add Tween-80 300ml and stir, and merge with above-mentioned mixed liquor, stir.Add 20% ethanol and adjust total amount to 1000ml, stir, transferring the solution pH value is 4.0～5.0, filter, and sterilization, fill, promptly.
Claims (4)
1. liquor preparations for removing dandruff, it is characterized in that, made by following crude drug and adjuvant: crude drug is Radix Et Rhizoma Rhei 150～250g, Radix Sophorae Flavescentis 150～250g, Cortex Dictamni 150～250g, Rhizoma Smilacis Glabrae 150～250g, Radix Gentianae 150～250g, Borneolum Syntheticum 15～25g, Mentholum 1～10g, ketoconazole 15～25g, clobetasol propionate 0.1～1.0g, and adjuvant comprises propylene glycol 20～100ml, glycerol 20～100ml, azone 10～30ml, Tween-80 50～150ml, sodium benzoate 1～10g.
2. solution as claimed in claim 1, it is characterized in that, described crude drug and adjuvant are: Radix Et Rhizoma Rhei 200g, Radix Sophorae Flavescentis 200g, Cortex Dictamni 200g, Rhizoma Smilacis Glabrae 200g, Radix Gentianae 200g, Borneolum Syntheticum 20g, Mentholum 5g, ketoconazole 20g, clobetasol propionate 0.5g, propylene glycol 50ml, glycerol 50ml, azone 20ml, Tween-80 80ml, sodium benzoate 5g.
3. as the preparation method of claim 1 or the described solution of 2 arbitrary claim, it is characterized in that, be following steps:
Radix Et Rhizoma Rhei, Cortex Dictamni, Rhizoma Smilacis Glabrae, Radix Sophorae Flavescentis, the Radix Gentianae of getting recipe quantity decoct with water, and filter, and filtrate concentrates, and adds ethanol, and cold preservation filters, and filtrate recycling ethanol does not extremely have the alcohol flavor, adds ethanol, add sodium benzoate and stir, and get solution A; It is complete that the ketoconazole of getting recipe quantity adds diluted hydrochloric acid dissolution, adds Tween-80, propylene glycol, glycerol, azone, stir, solution B; Solution A is joined in the solution B, get solution C; Mentholum, Borneolum Syntheticum, the clobetasol propionate of getting recipe quantity add dissolve with ethanol, add Tween-80 and stir, and get solution D; Solution D is joined in the solution C, stir, add ethanol and adjust total amount; Transfer the solution pH value, filter, sterilization, fill, promptly.
4. the preparation method of solution as claimed in claim 3 is characterized in that, is following steps:
Radix Et Rhizoma Rhei 200g, Radix Sophorae Flavescentis 200g, Cortex Dictamni 200g, Rhizoma Smilacis Glabrae 200g, Radix Gentianae 200g decoct with water secondary, 2 hours for the first time, 1 hour for the second time, filter, filtrate is concentrated into relative density and is determined as 1.12-1.14 under 60 ℃, adding ethanol makes the alcohol amount to 60%, cold preservation 24 hours filters, and filtrate recycling ethanol is to there not being the alcohol flavor, adding ethanol makes the alcohol amount to 20%, add sodium benzoate 5g, stir, get solution A; Ketoconazole 20g adds 11.7% dilute hydrochloric acid 50ml dissolving fully, adds Tween-80 50ml, propylene glycol 50ml, glycerol 50ml, azone 20ml, stir, solution B; Solution A is joined in the solution B, get solution C; Mentholum 5g, Borneolum Syntheticum 20g, clobetasol propionate 0.5g add the 30ml dissolve with ethanol, add Tween-80 30ml and stir, and get solution D; Solution D is joined in the solution C, stir, get settled solution, add 20% ethanol and adjust total amount, stir to 1000ml; Transferring the solution pH value is 4.0～5.0, filter, and sterilization, fill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN200610045260A CN101095799B (en) | 2006-06-30 | 2006-06-30 | Liquor preparations for removing dandruff and method for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200610045260A CN101095799B (en) | 2006-06-30 | 2006-06-30 | Liquor preparations for removing dandruff and method for preparing the same |
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| CN101095799B true CN101095799B (en) | 2010-05-12 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614102B (en) * | 2012-04-27 | 2013-05-08 | 昆明远方生物制品有限公司 | Dandruff-removing medicinal composition and preparation method thereof |
| CN102697669A (en) * | 2012-06-19 | 2012-10-03 | 广西博科药业有限公司 | Compound ketoconazole liquid shampoo |
| CN103860567B (en) * | 2014-04-02 | 2015-09-30 | 符代兵 | One treats dermopathic external used medicine and preparation method thereof |
| CN105169122A (en) * | 2014-05-30 | 2015-12-23 | 谈丽娜 | Dandruff-removing solution and preparation method thereof |
| CN104208534A (en) * | 2014-09-22 | 2014-12-17 | 龚川瑞 | Anti-scurf pharmaceutical composition and preparation method thereof |
| CN104398417A (en) * | 2014-11-06 | 2015-03-11 | 陈爱华 | Plant air conditioner |
| CN104288062A (en) * | 2014-11-11 | 2015-01-21 | 覃海兰 | Anti-dandruff shampoo |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1230417A (en) * | 1998-03-31 | 1999-10-06 | 孙顺孝 | Specific scurf-eliminating hair protecting tincture |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1230417A (en) * | 1998-03-31 | 1999-10-06 | 孙顺孝 | Specific scurf-eliminating hair protecting tincture |
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