CN114306478B

CN114306478B - A Chinese medicinal composition for treating dermatoses

Info

Publication number: CN114306478B
Application number: CN202011050039.6A
Authority: CN
Inventors: 陶强
Original assignee: JIANGXI CHILDREN' HOSPITAL
Current assignee: JIANGXI CHILDREN' HOSPITAL
Priority date: 2020-09-29
Filing date: 2020-09-29
Publication date: 2023-11-10
Anticipated expiration: 2040-09-29
Also published as: CN114306478A

Abstract

The invention discloses a traditional Chinese medicine composition for treating skin diseases. The Chinese medicinal composition has effects of clearing heat and eliminating dampness, cooling blood and removing toxic substances, relieving pain and swelling, and relieving itching, and can be used for effectively treating dermatoses, especially children dermatoses such as atopic dermatitis, diaper dermatitis, eczema, miliaria, pustular herpes, urticaria, etc., and has less liability to occurrence of dependency dermatitis and local pigmentation.

Description

A Chinese medicinal composition for treating dermatoses

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating skin diseases (especially children's skin diseases) and a preparation method thereof.

Background

The skin is the outermost organ of the human body, which covers the whole body. The skin not only has the functions of feeling, secretion, excretion, respiration, body temperature regulation, absorption and the like, but also has the protection effect on human bodies. Especially children have weak skin, thin horny layer, little sebum secretion and poor resistance, and are easy to infect skin diseases. Common skin diseases of children include miliaria, urticaria, eczema, diaper dermatitis, insect dermatitis and the like, which cause the children to be dysphoric, crying and anxiety, seriously harm the physical and mental health of the children, and bring a plurality of trouble to parents.

The most of the existing medicines for treating skin diseases are chemical preparations, mostly depend on corticoids, antibiotics and the like, and are easy to cause dependent dermatitis, local pigmentation, hirsutism and other symptoms after long-term use.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention provides a traditional Chinese medicine composition which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-50 parts of honeysuckle, 10-50 parts of weeping forsythiae capsule, 10-50 parts of amur corktree bark, 5-40 parts of giant knotweed, 10-50 parts of Chinese violet, 5-40 parts of lightyellow sophora root, 5-40 parts of fructus kochiae, 10-50 parts of dandelion, 5-40 parts of red bean, 10-50 parts of rehmannia root, 5-40 parts of Chinese angelica and 5-40 parts of mirabilite.

In one embodiment of the invention, the traditional Chinese medicinal materials consist of the following components in parts by weight: 10-50 parts of honeysuckle, 10-50 parts of weeping forsythiae capsule, 10-50 parts of amur corktree bark, 5-40 parts of giant knotweed, 10-50 parts of Chinese violet, 5-40 parts of lightyellow sophora root, 5-40 parts of fructus kochiae, 10-50 parts of dandelion, 5-40 parts of red bean, 10-50 parts of rehmannia root, 5-40 parts of Chinese angelica and 5-40 parts of mirabilite.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of the honeysuckle can be 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45 and 50 parts.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of weeping forsythia can be 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45 and 50 parts.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of the amur corktree bark can be 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45 and 50 parts.

Specifically, the weight parts of the giant knotweed in the traditional Chinese medicine raw materials can be 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35 and 40 parts.

Specifically, the Chinese medicinal materials include, by weight, 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45, and 50 parts of herba Violae.

Specifically, the weight parts of the kuh-seng in the traditional Chinese medicine raw materials can be 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35 and 40 parts.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of the fructus kochiae can be 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35 and 40 parts.

Specifically, in the traditional Chinese medicine raw materials, the dandelion can be 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45 and 50 parts by weight.

Specifically, in the traditional Chinese medicine raw materials, the parts by weight of the red beans can be 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35 and 40 parts.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of rehmannia can be 10, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 45 and 50 parts.

In one embodiment of the present invention, the rehmannia root is rehmannia root.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of angelica sinensis can be 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35 and 40 parts.

Specifically, in the traditional Chinese medicine raw materials, the weight parts of mirabilite can be 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35 and 40 parts.

In one embodiment of the invention, the composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 30 parts of honeysuckle, 30 parts of weeping forsythia, 30 parts of amur corktree bark, 20 parts of giant knotweed, 30 parts of Chinese violet, 20 parts of lightyellow sophora root, 20 parts of belvedere fruit, 30 parts of dandelion, 20 parts of red bean, 30 parts of radix rehmanniae, 20 parts of Chinese angelica and 20 parts of mirabilite.

In one embodiment of the invention, the traditional Chinese medicinal materials consist of the following components in parts by weight: 30 parts of honeysuckle, 30 parts of weeping forsythia, 30 parts of amur corktree bark, 20 parts of giant knotweed, 30 parts of Chinese violet, 20 parts of lightyellow sophora root, 20 parts of belvedere fruit, 30 parts of dandelion, 20 parts of red bean, 30 parts of radix rehmanniae, 20 parts of Chinese angelica and 20 parts of mirabilite.

In one embodiment of the invention, the above composition is a pharmaceutical composition.

Specifically, the pharmaceutical composition may further comprise pharmaceutically acceptable excipients.

Specifically, the above pharmaceutical composition may be in any form or administration form, particularly in a form for external use, such as powder, lotion, paste, film, gel, aerosol, etc.

In one embodiment of the invention, the pharmaceutical composition is a lotion.

The various dosage forms of the above pharmaceutical composition may be prepared according to conventional production methods in the pharmaceutical field.

Specifically, the above pharmaceutical composition can be prepared by a preparation method comprising the steps of:

(1) Soaking flos Lonicerae in water, and filtering;

(2) Decocting the filter residue obtained in the step (1) together with other traditional Chinese medicinal materials of the composition, and filtering;

(3) And (3) combining the filtrate obtained in the step (1) with the filtrate obtained in the step (2).

Specifically, the water used in the step (1) is boiling water.

Specifically, the soaking in step (1) may be 1 or more times (e.g., 2, 3, 4, etc.).

Specifically, the decoction in step (2) may be 1 or more times (e.g., 2, 3, 4, etc.); in one embodiment of the present invention, the decocting in step (2) is performed twice, the first time may be 0.5-1.5 hours (e.g. 0.5, 0.8, 1.0, 1.2, 1.5 hours), and the second time may be 20-60 minutes (e.g. 20, 30, 40, 45, 50, 55, 60 minutes).

Specifically, the preparation method can further comprise the step of volume fixing.

Specifically, the above preparation method may further comprise a step of sterilization.

Specifically, the preparation method can further comprise the step of sub-packaging.

The invention also provides application of the composition in preparing a medicament for preventing and/or treating skin diseases.

In particular, the skin diseases are pediatric skin diseases such as atopic dermatitis, contact dermatitis (e.g. diaper dermatitis), eczema, heat rash, pustular dermatitis, urticaria, papular urticaria, allergic purpura, varicella, hand-foot-and-mouth disease, urinary tract infection, etc.

Specifically, the children are children of 0-14 years old, 0-10 years old, 0-5 years old, 0-3 years old, 0-2 years old, especially 0-1 year old.

The present invention also provides a method of preventing and/or treating skin disorders comprising the step of administering to a subject the above-described composition of the present invention.

In particular, the subject is a child, particularly a child aged 0-14, 0-10, 0-5,0-3,0-2, more particularly a child aged 0-1.

The traditional Chinese medicine composition provided by the invention can clear heat and remove dampness, cool blood and detoxify, relieve pain and swelling and relieve itching, can effectively treat skin diseases, especially children skin diseases, such as atopic dermatitis, diaper dermatitis, eczema, miliaria, pustule, urticaria and the like, and is not easy to produce side effects such as dependency dermatitis, local pigmentation and the like.

Detailed Description

Unless defined otherwise, all scientific and technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention relates.

"skin disorders" are a generic term for disorders occurring in the skin and skin appendages, and can be divided into: viral skin diseases (e.g., herpes simplex, herpes zoster, warts (verruca vulgaris, plantar warts, flat warts, molluscum contagiosum, condyloma acuminatum), varicella, rubella, hand-foot-and-mouth disease, etc.), bacterial skin diseases (e.g., impetigo, folliculitis, furuncles, carbuncles, cellulitis, erysipelas, etc.), fungal skin diseases (e.g., tinea capitis, tinea cruris, tinea manus, tinea pedis, onychomycosis, pityriasis versicolor, malassezia folliculitis, etc.), animal-induced skin diseases (e.g., scabies, dermatitis acarina, cryptopteris dermatitis, pediculosis, insect chelating or biting, etc.), sexually transmitted diseases (e.g., syphilis, gonorrhea, nongonococcal urethritis, condyloma acuminatum, etc.), allergic and autoimmune skin diseases (e.g., contact dermatitis, eczema, urticaria; allergic dermatitis, drug dermatitis, etc.), physical skin diseases (such as solar dermatitis, summer dermatitis, miliaria, chilblain, corns, rhagades manus, pressure sores, etc.), nervous dysfunction skin diseases (such as pruritus, neurodermatitis, and delusions of parasites), erythema papulosquamous skin diseases (such as psoriasis, pityriasis simplex, pityriasis rosea, lichen planus, erythroderma), connective tissue diseases (such as lupus erythematosus, scleroderma, sjogren's syndrome, dermatomyositis, etc.), bullous skin diseases (such as bullous herpes, etc.), pigment disorder skin diseases (such as chloasma, vitiligo, tattoo, freckle, pigmented nevus, coffee stain, chloasma, freckle nevus, rayleigh (Riehl) melanosis, port Zhou Heizi, port nevus pigmentosus, hair-black son disease, facial-neck follicular erythema melanosis, etc.), pigmentary nevus, and the like, pigmentary pityriasis rosea, moles, congenital moles, fold reticulon abnormalities, mongolian spots, tattoo, vitiligo, leucochrome moles, eccentric acquired white spots, hereditary symmetric dyschromatosis, anemic moles, etc.), skin appendicular diseases (such as acne, rosacea, seborrheic dermatitis, alopecia areata, hyperhidrosis, and bromhidrosis, etc.), hereditary dermatological diseases (such as ichthyosis, mao Zhou keratosis, lichen ruber, hereditary bullous epidermolysis, familial benign chronic pemphigus, etc.), dystrophic dermatological diseases (such as vitamin deficiency (bufonis venereal, riboflavin deficiency, nicotinic acid deficiency, etc.), skin tumors (precancerous dermatological diseases such as solar keratosis, leukoplakia; malignant skin tumors such as bowden disease (carcinoma in situ of the skin), eczematoid cancer (Paget's disease), basal cell carcinoma, squamous cell carcinoma, mycosis fungoides, malignant melanoma, etc. In the present invention, skin diseases, particularly pediatric skin diseases, specifically, atopic dermatitis, contact dermatitis (such as diaper dermatitis), eczema, heat rash (i.e., miliaria), pustule, urticaria, papular urticaria (also called insect bite dermatitis), allergic purpura, varicella, hand-foot-and-mouth disease, urinary tract infection, and the like.

"child" means a human from the beginning of life birth to the end of adulthood, and in the present invention, the age of childhood is 0-18 years (e.g., 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 years), especially 0-10 years, 0-5,0-3,0-2,0-1 years.

The term "effective amount" refers to the amount that achieves treatment, prevention, alleviation and/or alleviation of a disease or a disorder of the present invention in a subject, which depends on a number of factors, including the age, weight, sex, natural health condition, nutritional condition, number and time of administration, metabolic rate, severity of the disorder, and subjective judgment of the treating physician, etc., and therefore the invention is not particularly limited.

The terms "patient", "subject" are used interchangeably herein and refer to an animal, such as a mammal, particularly such as a human, and in particular a child, that receives the compositions and methods of the present invention to treat, prevent, ameliorate and/or alleviate a disease or disorder described herein.

The term "treating" includes eradicating, removing, reversing, alleviating, altering or controlling the disease or disorder after its onset.

The term "preventing" refers to the ability to prevent, minimize or make difficult the onset or progression of a disease or disorder by treatment prior to the onset of the disease or disorder.

The traditional Chinese medicines of the raw materials in the composition of the invention are well described in Chinese pharmacopoeia, chinese dictionary and Chinese herbal medicine, for example:

honeysuckle flower, source: dried flower bud or flower with primary opening of Lonicera japonica thunb Lonicera japonica of Caprifoliaceae, lonicera rubra Lonicera hypoglauca Miq, lonicera confusa DC or Lonicera macranthoides Lonicera dasystyla red; sweet in taste and cold in nature; enter lung, heart and stomach meridians; efficacy: clearing heat and detoxicating, cooling and dispelling wind heat; the processing method comprises the following steps: removing residual stems, leaves and impurities, and sieving to remove dust.

Fructus forsythiae, source: dried fruit of the plant forsythia Forsythia suspensa (thunder.) of the family Oleaceae, vahl; bitter taste and slightly cold nature; enter the lung, heart and small intestine meridians; efficacy: clearing heat and detoxicating, detumescence and resolving hard mass; the processing method comprises the following steps: removing impurities, rubbing off, and removing branch.

Phellodendron bark, source: dried bark of phellodendron amurense Phellodendron chinense Schneid. Or phellodendron Phellodendron amurense Rupr. Of Rutaceae, the former is known as "cortex Phellodendri", the latter is known as "cortex Phellodendri"; bitter taste and cold nature; kidney and bladder meridian; efficacy: clearing heat and drying dampness, purging fire and removing steam, and detoxicating and treating sore; the processing method comprises the following steps: removing impurities, cleaning with water, taking out, moistening, slicing, shredding, and sun drying.

Giant knotweed rhizome, source: dried rhizome and root of polygonum cuspidatum Polygonum cuspidatum sieb.et zucc; slightly bitter in taste and slightly cold in nature; enter liver, gall bladder and lung meridian; efficacy: dispelling wind and promoting diuresis, removing blood stasis and relieving pain, relieving cough and reducing sputum; the processing method comprises the following steps: removing impurities, cleaning, moistening, slicing, and drying.

Viola yedoensis makino, source: dried whole herb of viola yedoensis of the family violaceae, viola yedoensis Viola yedoensis Makino; bitter and pungent taste, cold nature; return to heart and liver meridian; efficacy: clearing heat and detoxicating, cooling blood and detumescence; the processing method comprises the following steps: removing impurities, cleaning, cutting, and drying.

The source of the kuh-seng is: dried root of Sophora flavescens ait Sophora flavescens Ait; bitter taste and cold nature; return to heart, liver, stomach, large intestine and bladder meridian; efficacy: clearing heat and drying dampness, killing parasites and promoting urination; the processing method comprises the following steps: removing residual root, separating, cleaning, soaking until six times of penetration, moistening thoroughly, cutting into thick slices, and drying.

Fructus Kochiae, source: dried ripe fruit of Kochia scoparia (l.) schrad; pungent and bitter in flavor and cold in nature; kidney and bladder meridian; efficacy: clearing heat and promoting diuresis, dispelling wind and relieving itching; the processing method comprises the following steps: harvesting whole plant in autumn when the fruit is mature, sun drying, removing the fruit, removing impurities such as branches and leaves.

Dandelion, source: dried whole herb of dandelion Taraxacum mongolicum hand-mazz, dandelion Taraxacum sinicum Kitag, or a congeneric plant; bitter and sweet in taste, cold in nature; enter liver and stomach meridians; efficacy: clearing heat and detoxicating, detumescence and resolving hard mass, inducing diuresis for treating stranguria; the processing method comprises the following steps: removing impurities, cleaning, and cutting.

Red bean, origin: dried mature seeds of leguminous plants red bean Phaseolus calcaratus roxb or red bean Phaseolus angularis Wight; sweet and sour, neutral in nature; return to heart and small intestine; efficacy: induce diuresis to alleviate edema, detoxify and drain pus; the processing method comprises the following steps: pulling out the whole plant when the autumn fruits are ripe and not cracked, sun-drying, threshing seeds, removing impurities, and sun-drying.

Rehmannia root, source: fresh or dried root tuber of rehmannia Rehmannia glutinosa Libosch of Scrophulariaceae; digging in autumn, removing head, fibrous root and silt, and fresh; or baking radix rehmanniae slowly to about eight times to dry, the former is known as "fresh radix rehmanniae", and the latter is known as "radix rehmanniae"; fresh rehmannia root: sweet and bitter in taste and cold in nature; radix rehmanniae: sweet in taste and cold in nature; return to heart, liver and kidney meridians; efficacy: fresh rehmannia root: clearing heat and promoting fluid production, cooling blood and stopping bleeding; radix rehmanniae: clear heat and cool blood, nourish yin and promote the production of body fluid.

Angelica, source: dried root of angelicae sinensis Angelica sinensis (oliv.) Diels of Umbelliferae; sweet and pungent taste and warm nature; enter liver, heart and spleen meridians; efficacy: replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation; the processing method comprises the following steps: removing impurities, cleaning, moistening, slicing, sun drying or low temperature drying.

Mirabilite, source: the sulfate mineral mirabilite is a crystal prepared by processing and refining mirabilite; salty and bitter in taste, cold in nature; stomach and large intestine channels; efficacy: purging heat and relaxing bowels, moistening dryness and softening hard masses, clearing fire and relieving swelling.

The technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Example 1: preparation

Formulation composition (i.e., skin wellness lotion applied in examples 3-5):

30g of honeysuckle, 30g of weeping forsythia, 30g of phellodendron bark, 20g of giant knotweed, 30g of viola philippica, 20g of kuh-seng, 20g of fructus kochiae, 30g of dandelion, 20g of semen Phaseoli, 30g of radix rehmanniae, 20g of Chinese angelica and 20g of mirabilite.

The preparation method comprises the following steps:

soaking flos Lonicerae in boiling water twice, filtering, and mixing filtrates; decocting the residue with other materials twice for 1 hr and 45 min, mixing decoctions, and filtering; adding the above flos Lonicerae soaking solution, adding water to total volume of 1000ml, stirring, packaging, sterilizing under damp heat, and sealing for storage.

The obtained product is a tan liquid and has slight fragrance.

Example 2: analysis and identification

Taking 20ml of the product liquid prepared in the example 1, placing the product liquid in a separating funnel, shaking and extracting twice (20 ml each time) by using diethyl ether, taking a water layer, evaporating the water layer on a water bath, ultrasonically treating residues by using 20ml of 1% hydrochloric acid methanol for 30 minutes, filtering, evaporating filtrate to dryness, and adding 1ml of 1% hydrochloric acid methanol into residues to dissolve the residues to obtain a sample solution;

and adding 1% hydrochloric acid methanol into berberine hydrochloride reference substance to obtain berberine hydrochloride solution containing 1mg per 1ml, and taking the berberine hydrochloride reference substance as reference substance solution.

Performing thin layer chromatography (appendix VI B of 2005 edition of Chinese pharmacopoeia), sucking 5 μl of each of the above two solutions, respectively spotting on the same silica gel G thin layer plate, taking benzene-ethyl acetate-methanol-isopropanol-concentrated ammonia solution (6:3:1.5:1.5:0.5) as developing agent, adding equal volume of concentrated ammonia solution into the other side tank, pre-balancing for 15 min, developing for about 8cm, taking out, air drying, and placing under ultraviolet lamp (365 nm) for inspection, wherein spots with the same color appear in the sample chromatogram at the positions corresponding to those of the control chromatogram.

Example 3: clinical diagnosis and treatment of cases

The hospital for children in the province of Jiangxi is picked to diagnose and treat the treatment cases of children in the hospital of 2019, as follows:

ID number/name/date of visit/prescription number/drug name/specification/number/diagnostic result

8600207805/Huangxiao certain/2019/6/1:14:51/36180/Pikang external lotion/250 ml/1.00/acute tonsillitis, urticaria

8600020486/Huangxiao certain/2019/6/3:16:30/76639/Pikang external lotion/250 ml/1.00/dyspepsia, malnutrition, rickets

8600154515/Huqicertain/2019/6/3:16:08:17/77633/Pikang external lotion/250 ml/3.00/urinary tract infection

101474423/Taobao/2019/6/4:54:56/90623/Pikang lotion/250 ml/1.00/urticaria

101123773/Huangxiao certain/2019/6/7:19:08:37/38612/Pikang external lotion/250 ml/1.00/acute pharyngitis

8600014661/horse somewhere/2019/6/8 9:33:43/44230/Pikang lotion/250 ml/3.00/urinary tract infection, frequency of urination

8600116435/Wanzhicertain/2019/6/8:37:12/44363/Pikang lotion/250 ml/2.00/allergic eczema

8600178973/wang certain/2019/6/8:15:36:05/51052/Pikang external lotion/250 ml/1.00/diarrhea, urinary tract infection

8600214974/Zhangxiao/2019/6/8:48:21/50914/Pikang external lotion/250 ml/3.00/urinary system disorder

8600215355/Hesome/2019/6/8:16:34:11/52055/Pikang external lotion/250 ml/3.00/urinary system disorder

101184358/Xiong Mou/2019/6/9:40:34/57609/skin wellness lotion/250 ml/2.00/atopic dermatitis

100922056/Momordica grosvenori/2019/6/9:15:21:52/65795/Pikang lotion/250 ml/2.00/allergic eczema

8600046086/Wen Jiujingzhi/2019/6/9:21:24:28/69525/Pikang lotion/250 ml/1.00/infectious fever, rash

100064638/Xiong Mou/2019/6/10:06:46/70461/skin health external lotion/250 ml/1.00/acute tonsillitis, acute urticaria

100767254/Wei somewhere/2019/6/10:11:02:18/79297/Pikang lotion/250 ml/1.00/pompholyx, acute pharyngitis, rash

101676612/Ozebra/2019/6/10:11:13:28/79698/Pikang lotion/250 ml/3.00/nephrotic syndrome

101421741/from somewhere/2019/6/10:23:28:52/88990/skin wellness lotion/250 ml/1.00/allergic rash

101683844/Pengsomewhere/2019/6/12:14:44:28/16846/Pikang lotion/250 ml/3.00/healthy controls, urinary tract infections

101591392/bear some/2019/6/12:19:39/17710/Pikang lotion/250 ml/2.00/urinary tract infection

8600099808/Lincertain/2019/6/12:15:39:22/18099/Pikang external lotion/250 ml/3.00/urinary tract infection

8600035364/from Kong/2019/6/12:17:51:14/20007/Pikang external lotion/250 ml/1.00/acute pharyngitis

101570644/Zhou Mou/2019/6/12:25:11/20511/skin wellness lotion/250 ml/1.00/acute pharyngitis

8600221060/Pengsomewhere/2019/6/13:27:37/35901/Pikang lotion/250 ml/1.00/infectious fever, scarlet fever-like erythema

101757222/bear some/2019/6/14:17:21/40772/skin wellness lotion/250 ml/3.00/skin superficial bruise

101570644/Zhou Mou/2019/6/14:23:48/41110/skin wellness lotion/250 ml/1.00/allergic dermatitis

8600009178/Taxiao/2019/6/14:25:16/48324/Pikang lotion/250 ml/1.00/acute angina, rash

101522982/1/2019/6/15:00:01/56673/skin care lotion/250 ml/2.00/atopic dermatitis

8600022567/Huqicertain/2019/6/15:32:04/57652/Pikang external lotion/250 ml/2.00/allergic purpura, skin infection

100826827/Dungsome/2019/6/15:35:56/64502/Pikang lotion/250 ml/2.00/prickly heat

101299392/horse somewhere/2019/6/15:40:07/64544/skin health external lotion/250 ml/1.00/allergic dermatitis

101664020/Liu somewhere/2019/6/16:10:47:57/75530/Pikang lotion/250 ml/1.00/allergic dermatitis

8600224283/Zhu certain/2019/6/17:57:14/84124/Pikang lotion/250 ml/1.00/infectious fever, acute tonsillitis, rash

8600224694/Momordica grosvenori/2019/6/17:24:28/98009/Pikang external lotion/250 ml/2.00/urinary tract infection

8600223686/nie certain/2019/6/17:52:17/98627/Pikang lotion/250 ml/3.00/proteinuria

8600225165/Huangxiao certain/2019/6/17:59:44/98758/Pikang external lotion/250 ml/1.00/urethritis, nephrotic syndrome

8600144980/Guo Mou/2019/6/18:31:14/4061/skin health external wash/250 ml/2.00/nephrotic syndrome

101290353/nie certain/2019/6/19 10:54:33/24216/Pikang external lotion/250 ml/1.00/eczematoid dermatitis

101100890/Huangxiao certain/2019/6/19:14:46:20/26849/Pikang lotion/250 ml/2.00/atopic dermatitis

100853628/Zhangcertain/2019/6/19:56:02/28457/Pikang lotion/250 ml/5.00/atopic dermatitis

101772094/somewhere/2019/6/20:51:39/44002/Pikang lotion/250 ml/2.00/acute urticaria, miliaria

100878960/Ducertain/2019/6/21 14:36:36/55555/Pikang lotion/250 ml/3.00/atopic dermatitis

101724551/Liu somewhere/2019/6/21:17:12:09/58183/Pikang lotion/250 ml/2.00/urticaria

101069537/fan somewhere/2019/6/22:16:40/65389/Pikang lotion/250 ml/2.00/atopic dermatitis

100752634/Lixisomebody/2019/6/22:00:40/70777/Pikang lotion/250 ml/1.00/allergic eczema

100316095/Hesome/2019/6/23:31:01/76092/Pikang lotion/250 ml/3.00/pruritus

8600057971/bear somewhere/2019/6/23:14:01/77205/skin health lotion/250 ml/1.00/viral rash

101210815/Zhangcertain/2019/6/23:55:57/78331/Pikang lotion/250 ml/3.00/atopic dermatitis

8600220253/Chen somewhere/2019/6/23:43:47/79589/Pikang lotion/250 ml/3.00/atopic dermatitis

8600230288/WANGZHONG/2019/6/23:46:32/79667/Pikang external lotion/250 ml/2.00/infantile eczema

8600230874/Zhou somewhere/2019/6/23:08:12/86084/Pikang lotion/250 ml/1.00/urticaria

8600201886/Lincertain/2019/6/28:34:07/66987/Pikang lotion/250 ml/1.00/allergic rash

The symptoms of the patients are improved and healed after the treatment.

100933367/Yao certain/2019/6/8:9:45:31/44698// atopic dermatitis

Example 4 diagnosis and treatment of patient 100933367

Date: 2019/6/8

The red spots and pimples on the whole body of the infant are itchy for 1 week, so that the infant is healthy. The father has good health condition, the mother has good health condition, and no family disease genetic history.

The infant has no obvious cause of erythema on the face before 1 week, and has pimple with needle point on the surface, desquamation, no erosion and exudation, obvious pruritus and gradual increase and expansion. Improved but repeated attacks after local outpatient treatment (specific diagnosis and treatment is not detailed). Many red spots are visible on the whole body, pimples with needle points on the surface are not eroded and exuded. Is diagnosed as atopic dermatitis.

The skin health external lotion (250 ml) was applied in two bottles, and the symptoms were significantly improved.

Example 5 diagnosis and treatment of patient 8600219221

Date: 2019/6/11

The infant rash is 1-2 days, the body is general, and the skin rash has no trauma or operation history. The father has good health condition, the mother has good health condition, the father is not matched with the mother in a near-to-near way, and the family disease genetic history is avoided.

The infant has no obvious cause of systemic eruption, no surprise, no cough and other discomfort before 1-2 days, and the infant has the symptoms of common spirit, common appetite, normal stool and normal urine. The body temperature is 36.5 ℃, the mind is clear, the spirit is soft, the breathing is stable, the bregma is closed, the pharynx is free from congestion, the tonsil is enlarged, the breathing sound of the two lungs is slightly thick, the heart sounds are strong without the dry and wet sounds, the arrhythmia, the heart sounds are strong, the abdomen is soft, and the pressure pain is avoided. The nerve system test was negative, the extremities were warm CRT 1S, and the whole body was scattered on the milioid papules. Is diagnosed as viral rash.

The skin health lotion (250 ml) was applied in 1 bottle, and the symptoms were significantly improved.

The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is to be construed as including any modifications, equivalents, and alternatives falling within the spirit and principles of the invention.

The foregoing embodiments and methods described in this invention may vary based on the capabilities, experience, and preferences of those skilled in the art.

The listing of the steps of a method in a certain order in the present invention does not constitute any limitation on the order of the steps of the method.

Claims

1. The application of a composition in preparing a medicament for external use for preventing and/or treating skin diseases is characterized in that the composition comprises the following components in parts by weight: 30 parts of honeysuckle, 30 parts of weeping forsythia, 30 parts of amur corktree bark, 20 parts of giant knotweed, 30 parts of Chinese violet, 20 parts of lightyellow sophora root, 20 parts of belvedere fruit, 30 parts of dandelion, 20 parts of red bean, 30 parts of radix rehmanniae, 20 parts of Chinese angelica and 20 parts of mirabilite;

the skin disease is children skin disease;

the pediatric dermatological disorder is selected from: atopic dermatitis, contact dermatitis, eczema, heat rash, pustular dermatitis, and urticaria.

2. The use of claim 1, wherein the child is a child aged 0-5 years.

3. The use according to claim 1, wherein the urticaria is papular urticaria.