CN105169183A - A traditional Chinese medicine composition for treating decubitus and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating bedsore and a preparation method thereof, belonging to the technical field of traditional Chinese medicines, and the traditional Chinese medicine composition comprises the following preparation raw materials: folium artemisiae argyi, rhizoma gastrodiae, rhizoma corydalis, herba houttuyniae, folium eucalypti globueli, centella asiatica, herba portulacae, frankincense, rhizoma ligustici wallichii, angelica sinensis, medlar, galangal, radix ampelopsis, garden burnet, fresh rehmannia and liquorice. The traditional Chinese medicine provided by the invention is reasonable in formula and strong in synergistic effect, has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, removing putrefaction toxin and promoting tissue regeneration and skin growth, can dredge blood vessels and meridians while removing putrefaction toxin, can accelerate the self metabolism of skin, enables toxin and bacteria to be rapidly discharged out of a sore, further enhances the immunity of an organism, enhances the resistance to bacteria and fungi, and avoids reinfection after wound healing.

Description

A traditional Chinese medicine composition for treating decubitus and preparation method thereof

technical field

The invention relates to a traditional Chinese medicine composition for treating decubitus and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background technique

Bed sores, also known as pressure sores (compression ulcers), are chronic pressure on local tissues, resulting in local tissue ulceration and necrosis due to continuous ischemia, hypoxia, and malnutrition. It is one of the common clinical complications. Traditional Chinese medicine is called "Xi sore", which is caused by long-term illness, great loss of qi and blood, long-term bed rest, local pressure, resulting in abnormal blood and qi circulation, blockage of meridians and collaterals, and no skin. In severe cases, it can cause sepsis and lead to death.

Compared with Chinese patent medicines, traditional western medicine often uses disinfectants or antibiotics when changing dressings. Although it can effectively control bacteria, it also inevitably inhibits the healthy regeneration of wound cells, resulting in very slow wound healing and protracted disease. , affecting the life and work of patients.

The main principles of traditional Chinese medicine treatment of decubitus are to clear away heat and detoxify, activate blood circulation and remove blood stasis, remove putrefaction and promote muscle growth, promote the discharge of necrotic tissue, accelerate the growth of granulation tissue, remove necrotic tissue from the body, improve the microcirculation of tissues around the wound, increase local blood flow, and promote Residual epithelial cell tissue grows, removes putrefaction and promotes granulation, activates the body's endogenous debridement process, manifests as painless debridement, has no side effects on normal tissues, fills wound sinuses and cavities, prevents wound collapse, relieves pain, and absorbs wound exudate liquid.

Chinese patent application 201510239732.0 discloses a traditional Chinese medicine ointment for treating decubitus. The ointment is made of the following raw materials: Cortex Phellodendri 10-12, Dried Blood 3-4, Comfrey 2-4, Astragalus 8-10, Angelica 5-6 , Atractylodes 2-4, Angelica 8-10, Codonopsis 4-5, Baishui 2-4, Frankincense 5-6, Myrrh 9-10, Chuanxiong 3-4, Trichosanthes 2-4, Antler Cream 6-7, Radix Paeoniae Alba 4-6, Stir-Fried Mountain Beetle 3-4, Stir-fried Saponaria thorn 1-3, Red Vine 6-8, Polygonum cuspidatum 4-5, Moutan Cortex 9-11, Artemisia argyi 2-4, Wine Coptis 4-5, Nuxychnium 8-10, amber 2-4, human face cotyledon 2-4, and big tea root 1-3. The ointment has a certain curative effect in treating bedsores, but the drug has a long course of treatment for bedsores, complex prescriptions of traditional Chinese medicines, and high treatment cost.

Contents of the invention

In order to solve the shortcomings of slow healing, long treatment time and high treatment cost in the medicines for treating bedsores in the prior art, the object of the present invention is to provide a traditional Chinese medicine composition for treating bedsores to solve the above problems. At the same time, the invention also provides a preparation process of the traditional Chinese medicine composition.

The traditional Chinese medicine composition of the present invention comprises the following preparation raw materials in parts by weight: Artemisia argyi 25-30, Tianma 10-19, Corydalis 4-10, Houttuynia 10-15, Eucalyptus 15-22, Centella asiatica 8-25, Purslane 5-15, Frankincense 13-19, Chuanxiong 14-20, Angelica 10-15, Lycium barbarum 6-12, Galangal 8-16, Scutellaria 4-8, Burnet 4-8, Fresh Rehmannia 10-16 and licorice 6-14.

Further, the traditional Chinese medicine composition includes the following preparation raw materials in parts by weight: Artemisia argyi 25, Gastrodia elata 10, Corydalis 4, Houttuynia cordata 10, Eucalyptus 15, Centella asiatica 8, purslane 5, frankincense 13, chuanxiong 14 , Angelica 10, wolfberry 6, galangal 8, white scorpion 4, Burnet 4, fresh rehmannia 10 and licorice 6.

Further, the traditional Chinese medicine composition includes the following preparation raw materials in parts by weight: Artemisia argyi 30, Tianma 19, Corydalis 10, Houttuynia 15, Eucalyptus 22, Centella asiatica 25, Purslane 15, Frankincense 19, Rhizoma Chuanxiong 20 , Chinese angelica 15, wolfberry 12, galangal 16, white scorpion 8, Burnet 8, fresh rehmannia 16 and licorice 14.

Further, the traditional Chinese medicine composition includes the following preparation raw materials in parts by weight: Artemisia argyi 22, Gastrodia elata 14, Corydalis 6, Houttuynia cordata 12, Eucalyptus 18, Centella asiatica 18, purslane 12, frankincense 15, chuanxiong 16 , Chinese angelica 13, wolfberry 8, galangal 14, white scorpion 6, Burnet 5, fresh rehmannia 14 and licorice 10.

Furthermore, the traditional Chinese medicine composition of the present invention is preferably made into powder, ointment or gel, which is convenient for patients to use.

In addition, the present invention also provides a preparation method of a Chinese medicine composition for treating decubitus, comprising the following steps:

S1: Take Gastrodia elata, wash it, dry it, crush it, pass it through a 80-100 mesh sieve, add 5-8 times the weight of Gastrodia elata coarse powder, and add ethanol with a concentration of 65-85%, soak for 6-12 hours, and store it at a temperature of 60-70°C Ultrasonic extraction twice, 40-60 minutes each time, the ultrasonic frequency is 25-35kHz, filtering, combining the filtrate, and concentrating the filtrate under reduced pressure to a clear paste with a relative density of 1.15-1.25 at 60°C to obtain the Gastrodia elata extract;

S2: Take mugwort leaves, Corydalis Corydalis, Houttuynia cordata, Eucalyptus leaves, Centella asiatica, purslane, frankincense, chuanxiong, angelica, wolfberry, galangal, white pomegranate, burnet, fresh rehmannia glutinosa and licorice, and mix them, add the above coarse powder The concentration of 6-8 times the total weight is 70-80% ethanol, soak for 6-12 hours, reflux extraction 2-3 times, each time for 2-6 hours, filter, combine the filtrates, and distill off the ethanol under reduced pressure. Concentrated to a concentrated solution with a relative density of 1.20-1.25 at 60°C;

S3: Mix the Gastrodia elata extract obtained in step S1 with the concentrated solution obtained in step S2, dry and pulverize to obtain.

The source, nature and flavor, meridian distribution and efficacy of the components used in the Chinese medicine composition of the present invention:

Artemisia argyi: This product is the dry leaf of Artemisia argyi of Compositae; bitter in taste, warm in nature; returns to liver, spleen, and kidney meridians; dispels cold to relieve pain, warms meridians to stop bleeding.

Gastrodia elata: the dry tuber of Gastrodia elata in the genus Gastrodia elata of Orchidaceae, tastes sweet, flat in nature, and returns to the liver meridian; relieves wind and spasm, calms the liver and subdues yang, dispels wind and dredges collaterals.

Corydalis Corydalis: This product is the dried tuber of Corydalis Corydalis of Poppyaceae; pungent, bitter, warm in nature; returns to liver and spleen meridians; promotes blood circulation, sharpens qi, and relieves pain.

Houttuynia cordata: This product is the dry aboveground part of the Sanbaiaceae plant Houttuynia cordata; acrid in taste, slightly warm; enters the liver and lung meridians; clears heat and detoxifies, diuretic and detumescence.

Eucalyptus leaf: This product is the leaf of Eucalyptus eucalyptus of Myrtaceae plant; bitter in taste, warm in nature; returns to lung, stomach, spleen, liver meridian; disperses wind and relieves exterior syndrome, clears heat and detoxification, reduces phlegm and regulates qi, kills insects and relieves itching.

Centella asiatica: This product is the dry whole herb of Centella asiatica; bitter in taste, cold in nature; returns to liver, spleen and kidney meridians; clears away heat and dampness, detoxifies and reduces swelling.

Purslane: This product is the dry aerial part of Purslane, a plant of the family Portulaca oleracea; sour in taste and cold in nature; it returns to the liver and large intestine meridian; it can clear away heat and detoxify, cool blood and stop bleeding.

Frankincense: This product is the Oleum gum resin exuded from the bark wound of the Boswellia tree of the olive family. It is used as medicine. It is pungent, bitter, and warm in nature.

Ligusticum Chuanxiong: This product is the dried rhizome of Ligusticum Chuanxiong of Umbelliferae; pungent in taste, warm in nature; returns to the liver, gallbladder, and pericardium meridians; promotes blood circulation and qi, dispels wind and relieves pain.

Angelica: This product is the dried root of Angelica sinensis; sweet in taste and warm in nature; it returns to the liver, heart, and spleen meridian; it nourishes blood and activates blood circulation, regulates menstruation and relieves pain, moistens the intestines and relieves constipation.

Lycium barbarum: This product is the dried and mature fruit of Lycium barbarum Ningxia, a plant of the family Solanaceae; sweet in taste, flat in nature;

Galangal: This product is the dried rhizome of Zingiberaceae galangal; spicy in taste, hot in nature; returns to spleen and stomach meridian; warms stomach and dispels cold, relieves indigestion and relieves pain.

Radix Scutellariae: This product is the dried root tuber of Rhizoma Radix Radix Vitis Potatoes; bitter in taste, slightly cold in nature; Guixin and Stomach Meridian; heat-clearing and toxic substances removing, eliminating carbuncle and dissipating stagnation.

Burnet: This product is the dry root of Burnet or Burnet longifolia of Rosaceae plant; bitter in taste, slightly cold in nature; enters the liver and large intestine meridian; cools blood to stop bleeding, detoxifies and suppresses sores.

Fresh Rehmannia glutinosa: This product is the fresh rhizome of Rehmannia glutinosa of Scrophulariaceae; tastes sweet and bitter, slightly cold in nature; enters the heart, liver, and kidney channels; clears away heat, cools blood, and promotes body fluid.

Licorice: This product is the dried root of leguminous plant licorice, bloated licorice or glabra; sweet in taste, flat in nature; heart, lung, spleen, stomach meridian; invigorating spleen and qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain , to reconcile the various medicines.

The prescription analysis of Chinese medicine prescription of the present invention:

The traditional Chinese medicine prescription of the present invention is based on Artemisia argyi, Gastrodia elata, and eucalyptus leaves as monarch drugs, dispelling cold and relieving pain, dispelling wind and relieving the exterior, clearing away heat and detoxifying; Reducing swelling, promoting muscle growth, dispelling wind and relieving pain; using angelica, wolfberry, galangal, white scorpion, burnet, and fresh rehmannia root as adjuvant medicines, nourishing blood and promoting blood circulation, eliminating food and relieving pain, detoxifying and relieving sores; using licorice as an envoy to make all medicines synergize Cooperate and complement each other to achieve the effects of detoxification and swelling, blood circulation and blood stasis removal, muscle growth and skin growth, etc., and have a very significant therapeutic effect on bedsores.

Compared with the prior art, the traditional Chinese medicine composition of the present invention has the effects of clearing away heat and detoxification, promoting blood circulation and removing blood stasis, removing putrefaction and promoting muscle growth in treating bedsores. Self-metabolism, so that toxins and bacteria can be quickly discharged from the sores, and at the same time further enhance the body's immunity, enhance the resistance to bacteria and fungi, and avoid re-infection after the wound has healed. Moreover, the preparation method provided by the invention is simple and easy to implement, has a wide application range, has little toxic and side effects, and is easy to popularize and apply.

Detailed ways

It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventors to function well in the practice of the invention. However, many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the invention.

Example 1

The traditional Chinese medicine composition of Example 1 of the present invention includes the following preparation raw materials in parts by weight: Artemisia argyi 25, Gastrodia elata 10, Corydalis 4, Houttuynia cordata 10, Eucalyptus 15, Centella asiatica 8, purslane 5, frankincense 13, chuanxiong 14 , Angelica 10, wolfberry 6, galangal 8, white scorpion 4, Burnet 4, fresh rehmannia 10 and licorice 6.

Preparation:

S1: Take Gastrodia elata, wash it, dry it, crush it, pass it through a 80-mesh sieve, add 65% ethanol in an amount 5 times the weight of Gastrodia elata coarse powder, soak for 6 hours, and extract it twice by ultrasonic at 60°C for 40 minutes each time. The ultrasonic frequency is 25kHz, filter, combine the filtrates, and concentrate the filtrates under reduced pressure to a clear paste with a relative density of 1.15 at 60°C to obtain the Gastrodia elata extract;

S2: Take mugwort leaves, Corydalis Corydalis, Houttuynia cordata, Eucalyptus leaves, Centella asiatica, purslane, frankincense, chuanxiong, angelica, wolfberry, galangal, white pomegranate, burnet, fresh rehmannia glutinosa and licorice, and mix them, add the above coarse powder The concentration of 6 times the total weight is 70% ethanol, soak for 6 hours, reflux extraction twice, each time for 2 hours, filter, combine the filtrate, remove ethanol by distillation under reduced pressure, and concentrate at 55°C to a concentrated concentration with a relative density of 1.20 liquid;

S3: Mix the Gastrodia elata extract obtained in step S1 with the concentrated solution obtained in step S2, dry, pulverize, and add corresponding auxiliary materials to make a powder.

Example 2

The Chinese medicine composition of Example 2 of the present invention includes the following preparation raw materials in parts by weight: Artemisia argyi 30, Tianma 19, Corydalis 10, Houttuynia 15, Eucalyptus 22, Centella asiatica 25, Purslane 15, Olibanum 19, Rhizoma Chuanxiong 20 , Chinese angelica 15, wolfberry 12, galangal 16, white scorpion 8, Burnet 8, fresh rehmannia 16 and licorice 14.

The preparation method is similar to that of Example 1 to prepare a gel.

Example 3

The traditional Chinese medicine composition of Example 3 of the present invention includes the following preparation raw materials in parts by weight: Artemisia argyi 22, Gastrodia elata 14, Corydalis 6, Houttuynia cordata 12, Eucalyptus 18, Centella asiatica 18, purslane 12, frankincense 15, chuanxiong 16 , Chinese angelica 13, wolfberry 8, galangal 14, white scorpion 6, Burnet 5, fresh rehmannia 14 and licorice 10.

The preparation method is similar to that of Example 1, and an ointment is made.

Pharmacodynamic experiment

One, Chinese medicine composition of the present invention treats guinea pig decubitus model test

1. Test material:

1.1 Experimental animals: male guinea pigs, body weight (275±25) g, provided by Animal Experiment Center of Nanjing Medical University.

1.2 Experimental drug: the ointment for treating bedsore prepared in Example 3, Mayinglong Musk Hemorrhoid Ointment, approved by the Chinese Medicine: Z42021920, was purchased from Mayinglong Pharmaceutical Group Co., Ltd.

2. Establishment of animal models: 36 guinea pigs were anesthetized, skin sterilized, fixed in a prone position, a 3cm long incision was made on the left side near the back spine, and a 4.0cmx2.5cmx0.05cm autoclaved guinea pig was implanted. Stainless steel plate, the incision was sutured, and the wound was bandaged and fixed with a bandage. Guinea pigs were fed in a single cage after operation, and ld was observed. After 24 hours, a 4.0cm×2.5cm×1.0cm magnet was used to compress the wound surface (5h/d), rest for 12h and cycle once, and the total compression time was 10h. The formation area and graduation grade of bedsores were recorded. The animals were separated into individual cages, and the feeding and management conditions were the same.

3. Test method: on the second day after the formation of the guinea pig decubitus model, the guinea pigs were randomly divided into 3 groups, 12 in each group, respectively normal group, positive control group and embodiment 3 groups, and each group was processed as follows:

Normal group: After cleaning the wound with 0.9% sodium chloride, no other treatment was done;

Positive control group: After cleaning the wound with 0.9% sodium chloride, apply Mayinglong Musk Hemorrhoid Ointment to the wound;

Example 3 group: After cleaning the wound with 0.9% sodium chloride, the ointment for treating decubitus prepared in Example 3 containing Artemisia argyi was applied to the wound;

The above operation is applied once a day, and the effect is judged after 14 days of medication.

4. Observation indicators:

According to the staging standard of decubitus ulcer, the cure means that the wound disappears and the epidermis heals; the improvement means that the wound shrinks by 80%, the granulation is fresh, grows well, the edema subsides, and there is less exudate;

5. Test results:

Table 1 Comparison of treatment effect and healing days of decubitus in guinea pigs

Note: Compared with the normal group, ^▲▲ P＜0.01.

As can be seen from Table 1, using the ointment for the treatment of decubitus prepared by the embodiment of the present invention 3, the wound is basically healed in about 10 days, and the cure rate reaches 83.3%, and the invalid rate is 0, which proves that the decubitus ointment prepared by the present invention has significant treatment for decubitus Effect.

Two, the clinical trial of Chinese medicine composition of the present invention

1. Clinical research object:

Select 120 clinical volunteer patients with decubitus ulcers, including 80 males and 40 females, aged 45-85 years old, the diameter of the sores was 1-30cm before treatment, 85 cases were in the ulcer stage, and 35 cases were in the deep ulcer stage; The patients were randomly divided into two groups, a treatment group and a control group, 60 people in each group. There was no significant difference in gender, age, disease severity and clinical manifestations between the two groups, and they were comparable.

2. Test drugs and test methods:

Treatment group: apply the ointment for treating decubitus prepared in Example 3 of the present invention, change the dressing once a day, 0.52-1.04 g each time, and observe continuously for 14 days.

Control group: the skin around the wound was disinfected with 75% alcohol, the wound was cleaned with 0.1% bromogeramine, and the necrotic tissue was cut off as much as possible, then covered with comfrey oil gauze, covered with sterile gauze, and the rest were the same as the observation group.

3. Efficacy standard:

It was formulated with reference to the "Diagnostic and Curative Criteria for Syndrome Diagnosis and Efficacy of Traditional Chinese Medicine" implemented by the Administration of Traditional Chinese Medicine and combined with the specific situation of this study.

Healing: the wound is healed, without inflammatory exudation, the sore surface shrinks, and new granulation tissue is formed and covered by epithelial tissue;

Effective: Wound infection is controlled, the sore surface shrinks >80%, granulation tissue is formed, but the wound is not completely healed;

Ineffective: There was no significant improvement in the comparison of the wound before and after treatment, no granulation growth was seen, and the wound shrank <40%.

4. Test results:

Table 1 Comparison of clinical efficacy between the two groups (%)

5. Test conclusion:

The test results show that the ointment for treating bedsores prepared by the present invention has a significant effect in treating bedsores, with a cure rate of 83.3% and a total effective rate of 96.7%, which is significantly better than that of the control group. The results of clinical trials show that the ointment for treating bedsores prepared by the invention has significant technical advantages in treating bedsores, and can be popularized and applied as a medicine for clinical treatment of bedsores.

Claims (6)

1. A Chinese medicine composition for the treatment of decubitus, characterized in that, said Chinese medicine composition comprises the following preparation raw materials in parts by weight: Artemisia argyi 25-30, Gastrodia elata 10-19, Corydalis 4-10, Houttuynia cordata 10-15 , Eucalyptus 15-22, Centella asiatica 8-25, Purslane 5-15, Frankincense 13-19, Chuanxiong 14-20, Angelica 10-15, Lycium barbarum 6-12, Galangal 8-16, Radix 4 -8, Burnet 4-8, Fresh Rehmannia 10-16 and Licorice 6-14. 2. the Chinese medicine composition for the treatment of decubitus as claimed in claim 1, is characterized in that, described Chinese medicine composition comprises the preparation raw material of following parts by weight: Folium Artemisiae Argyi 25, Tianma 10, Corydalis Corydalis 4, Houttuynia cordata 10, Eucalyptus 15. Centella Asiatica 8, Purslane 5, Frankincense 13, Ligusticum Chuanxiong 14, Angelica 10, Lycium barbarum 6, Galangal 8, Pollen 4, Burnet 4, Fresh Rehmannia glutinosa 10 and Licorice 6. 3. the Chinese medicine composition for the treatment of decubitus as claimed in claim 1, is characterized in that, described Chinese medicine composition comprises the preparation raw material of following parts by weight: Folium Artemisiae Argyi 30, Tianma 19, Corydalis Corydalis 10, Houttuynia cordata 15, Eucalyptus 22. Centella asiatica 25, Purslane 15, Frankincense 19, Rhizoma Chuanxiong 20, Angelica 15, Lycium barbarum 12, Galangal 16, Radish 8, Burnet 8, Fresh Rehmannia glutinosa 16 and Licorice 14. 4. the Chinese medicine composition for the treatment of decubitus as claimed in claim 1, is characterized in that, described Chinese medicine composition comprises the preparation raw material of following parts by weight: Folium Artemisiae Argyi 22, Tianma 14, Corydalis Corydalis 6, Houttuynia cordata 12, Eucalyptus 18. Centella asiatica 18, purslane 12, frankincense 15, chuanxiong 16, angelica 13, wolfberry 8, galangal 14, white pomegranate 6, Burnet 5, fresh rehmannia glutinosa 14 and licorice 10. 5. The Chinese medicine composition for treating decubitus as claimed in any one of claims 1-4, characterized in that: said Chinese medicine composition is made into powder, ointment or gel. 6. A method for preparing the Chinese medicine composition for the treatment of decubitus as described in any one of claims 1-4, is characterized in that comprising the steps: S1: Take Gastrodia elata, wash it, dry it, crush it, pass it through a 80-100 mesh sieve, add 5-8 times the weight of Gastrodia elata coarse powder, and add ethanol with a concentration of 65-85%, soak for 6-12 hours, and store it at a temperature of 60-70°C Ultrasonic extraction twice, 40-60 minutes each time, the ultrasonic frequency is 25-35kHz, filtering, combining the filtrate, and concentrating the filtrate under reduced pressure to a clear paste with a relative density of 1.15-1.25 at 60°C to obtain the Gastrodia elata extract; S2: Take mugwort leaves, Corydalis Corydalis, Houttuynia cordata, Eucalyptus leaves, Centella asiatica, purslane, frankincense, chuanxiong, angelica, wolfberry, galangal, white pomegranate, burnet, fresh rehmannia glutinosa and licorice, and mix them, add the above coarse powder The concentration of 6-8 times the total weight is 70-80% ethanol, soak for 6-12 hours, reflux extraction 2-3 times, each time for 2-6 hours, filter, combine the filtrates, and distill off the ethanol under reduced pressure. Concentrated to a concentrated solution with a relative density of 1.20-1.25 at 60°C; S3: Mix the Gastrodia elata extract obtained in step S1 with the concentrated solution obtained in step S2, dry and pulverize to obtain.