CN105169183A - Traditional Chinese medicine composition for treating bedsores and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating bedsores and preparation method thereof Download PDF

Info

Publication number
CN105169183A
CN105169183A CN201510654917.8A CN201510654917A CN105169183A CN 105169183 A CN105169183 A CN 105169183A CN 201510654917 A CN201510654917 A CN 201510654917A CN 105169183 A CN105169183 A CN 105169183A
Authority
CN
China
Prior art keywords
radix
rhizoma
chinese medicine
medicine composition
herba
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201510654917.8A
Other languages
Chinese (zh)
Inventor
阚积香
王怀芬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Linyi Caozhimei Pharmaceutical Technology Co Ltd
Original Assignee
Linyi Caozhimei Pharmaceutical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Linyi Caozhimei Pharmaceutical Technology Co Ltd filed Critical Linyi Caozhimei Pharmaceutical Technology Co Ltd
Priority to CN201510654917.8A priority Critical patent/CN105169183A/en
Priority to CN201610296314.XA priority patent/CN105853866A/en
Publication of CN105169183A publication Critical patent/CN105169183A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9062Alpinia, e.g. red ginger or galangal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention relates to a traditional Chinese medicine composition for treating bedsores and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine is prepared from folium artemisiae argyi, gastrodia elata, corydalis tuber, cordate houttuynia, folium eucalypti, centella, purslane, frankincense, ligusticum wallichii, angelica sinensis, the fruits of Chinese wolfberry, galangal, ampelopsis japonica, garden burnet, fresh rehmannia and liquorice. The traditional Chinese medicine composition is reasonable in traditional Chinese medicines formula and strong in synergistic effect, has the effects of clearing away heat and toxic materials, invigorating the circulation of blood and removing stasis, eliminating decay toxin and promoting granulation and skin growth, can unblock blood vessels and meridians while eliminating decay toxin, and can accelerate skin self-metabolism to enable toxin and bacteria to be rapidly discharged from sore open parts; meanwhile, the immunity of the organism is further enhanced, the bacteria and fungus resistance is enhanced, and secondary infection caused by wound healing is avoided.

Description

A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Decubital ulcer has another name called pressure ulcer (pressure ulcer), is the normal phase pressurized of local organization, continuous ischemia, anoxia, malnutrition and cause local organization fester, downright bad, be one of clinical common complication.The traditional Chinese medical science is called " bed-sore ", is because prolonged illness QI and blood is lost greatly, long-term bed, local compression so that vim and vigour running not normal, meridians block, and are difficult caused by flourish skin, and as given treatment to not in time, meat rotten bone dew concurrent infection, causes septicemia time serious, cause death.
Compared with Chinese patent medicine, many application disinfectant or antibiotic when traditional doctor trained in Western medicine is changed dressings, although effectively can control antibacterial, but also inevitably inhibit the health regeneration of wound surface cell, thus causing wound healing slowly, protracted inflammation is not healed, and affects the live and work of patient.
The main principle for the treatment of by Chinese herbs decubital ulcer is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, promotes that slough is discharged, and accelerates granulation tissue growth, necrotic tissue cleaning is external, improve the microcirculation of wound surface surrounding tissue, increase regional flow, can promote that remaining epithelial cell tissues grows, putrefaction-removing granulation-promoting simultaneously, activate body endogenous debridement process, show as painless debridement, normal tissue has no side effect, and fills wound sinus tract and lacuna, prevents wound from subsiding, ease the pain, absorb wound exudate.
Chinese patent application 201510239732.0 discloses a kind of Chinese medicine ointment being used for the treatment of decubital ulcer, this ointment is obtained by following raw material: Cortex Phellodendri 10-12, Sanguis Draxonis 3-4, Radix Arnebiae (Radix Lithospermi) 2-4, Radix Astragali 8-10, Radix Angelicae Dahuricae 5-6, Rhizoma Atractylodis 2-4, Radix Angelicae Sinensis 8-10, Radix Codonopsis 4-5, Radix Ampelopsis 2-4, Olibanum (processed) 5-6, Myrrha 9-10, Rhizoma Chuanxiong 3-4, Radix Trichosanthis 2-4, Cornu Cervi Degelatinatum 6-7, Radix Paeoniae Alba 4-6, fry Squama Manis 3-4, fry Spina Gleditsiae 1-3, Caulis Sargentodoxae 6-8, Rhizoma Polygoni Cuspidati 4-5, Cortex Moutan 9-11, Folium Artemisiae Argyi 2-4, Rhizoma Coptidis (processed with wine) 4-5, Semen Strychni (processed) 8-10, succinum 2-4, Fructus Dracontomeli Duperreani leaf 2-4, and Herba Gelsemii Elegantis 1-3.This ointment has certain curative effect in treatment decubital ulcer, but this Drug therapy decubital ulcer is long for the course for the treatment of, and Chinese prescription is complicated, and treatment cost is high.
Summary of the invention
There is to solve in prior art the medicine for the treatment of decubital ulcer the shortcoming that healing is slow, treatment time is long and treatment cost is high, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of decubital ulcer, to solve the problem.Meanwhile, the present invention also provides the preparation technology of this Chinese medicine composition.
Chinese medicine composition of the present invention comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 25-30, Rhizoma Gastrodiae 10-19, Rhizoma Corydalis 4-10, Herba Houttuyniae 10-15, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-22, Herba Centellae 8-25, Herba Portulacae 5-15, Olibanum 13-19, Rhizoma Chuanxiong 14-20, Radix Angelicae Sinensis 10-15, Fructus Lycii 6-12, Rhizoma Alpiniae Officinarum 8-16, Radix Ampelopsis 4-8, Radix Sanguisorbae 4-8, Radix Rehmanniae 10-16 and Radix Glycyrrhizae 6-14.
Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 25, Rhizoma Gastrodiae 10, Rhizoma Corydalis 4, Herba Houttuyniae 10, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15, Herba Centellae 8, Herba Portulacae 5, Olibanum 13, Rhizoma Chuanxiong 14, Radix Angelicae Sinensis 10, Fructus Lycii 6, Rhizoma Alpiniae Officinarum 8, Radix Ampelopsis 4, Radix Sanguisorbae 4, Radix Rehmanniae 10 and Radix Glycyrrhizae 6.
Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Rhizoma Gastrodiae 19, Rhizoma Corydalis 10, Herba Houttuyniae 15, Folium eucalypti globueli (Eucalyptus globulus Labill.) 22, Herba Centellae 25, Herba Portulacae 15, Olibanum 19, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Fructus Lycii 12, Rhizoma Alpiniae Officinarum 16, Radix Ampelopsis 8, Radix Sanguisorbae 8, Radix Rehmanniae 16 and Radix Glycyrrhizae 14.
Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22, Rhizoma Gastrodiae 14, Rhizoma Corydalis 6, Herba Houttuyniae 12, Folium eucalypti globueli (Eucalyptus globulus Labill.) 18, Herba Centellae 18, Herba Portulacae 12, Olibanum 15, Rhizoma Chuanxiong 16, Radix Angelicae Sinensis 13, Fructus Lycii 8, Rhizoma Alpiniae Officinarum 14, Radix Ampelopsis 6, Radix Sanguisorbae 5, Radix Rehmanniae 14 and Radix Glycyrrhizae 10.
Further, Chinese medicine composition of the present invention preferably makes powder, ointment or gel, is convenient to patient and uses.
In addition, present invention also offers a kind of preparation method for the treatment of the Chinese medicine composition of decubital ulcer, comprise the following steps:
S1: get Rhizoma Gastrodiae and clean, crushed after being dried, cross 80-100 mesh sieve, adding Rhizoma Gastrodiae coarse powder weight 5-8 times amount concentration is the ethanol of 65-85%, soak 6-12 hour, supersound extraction twice at 60-70 DEG C of temperature, each 40-60 minute, supersonic frequency is 25-35kHz, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is the clear paste of 1.15-1.25, obtains Rhizoma Gastrodiae extract;
S2: get Folium Artemisiae Argyi, Rhizoma Corydalis, Herba Houttuyniae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Herba Portulacae, Olibanum, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae and be pulverized and mixed, the concentration adding above-mentioned coarse powder gross weight 6-8 times amount is 70-80% ethanol, soak 6-12 hour, reflux, extract, 2-3 time, each 2-6 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, is concentrated into the concentrated solution that relative density is 1.20-1.25 under 55-60 DEG C of condition;
S3: the concentrated solution that the Rhizoma Gastrodiae extract obtained by step S1 and step S2 obtain mixes, and dry, pulverize, and to obtain final product.
In Chinese medicine composition of the present invention component used source, nature and flavor, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Bitter in the mouth, warm in nature; Return liver,spleen,kidney warp; Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Rhizoma Gastrodiae: the dry tuber of the orchid family Gastrodia plant Rhizoma Gastrodiae, taste taste, sweet, property is put down, and returns Liver Channel; Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
Rhizoma Corydalis: this product is the dry tuber of papaveraceae plant corydalis; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Invigorate blood circulation, promoting the circulation of QI, pain relieving.
Herba Houttuyniae: this product is the dry aerial parts of saururaceae plant houttuynia cordata; Acrid in the mouth, tepor; Enter liver, lung two warp; Heat-clearing and toxic substances removing, inducing diuresis to remove edema.
Folium eucalypti globueli (Eucalyptus globulus Labill.): this product is the leaf for myrtle Eucalyptus globulus Labill; Bitter in the mouth, warm in nature; Return lung, stomach, spleen, Liver Channel; Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, killing parasites for relieving itching.
Herba Centellae: this product is the dry herb of samphire Herba Centellae; Bitter in the mouth, cold in nature; Return liver,spleen,kidney warp; Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.
Herba Portulacae: this product is the dry aerial parts of portulacaceous plant Herba Portulacae; Sour in the mouth, cold in nature; Return liver, large intestine channel; Heat-clearing and toxic substances removing, cooling blood for hemostasis.
Olibanum: this product is that the oleo-gum-resin that Burseraceae Boswellia carterii platymiscium Boswellia carterii is oozed out with its trunk skin zone wound is used as medicine; Acrid in the mouth, hardship, warm in nature; Enter the heart, liver, spleen channel; Promoting blood circulation and stopping pain.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, warm in nature; Return liver, the heart, spleen channel; Enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum; Sweet in the mouth, property is put down; Return liver, kidney channel; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Rhizoma Alpiniae Officinarum: this product is the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum; Acrid in the mouth, hot in nature; Return spleen, stomach warp; Warming stomach for dispelling cold, help digestion pain relieving.
Radix Ampelopsis: this product is the dried root of vitaceae Radix Ampelopsis; Bitter in the mouth, cold nature; GUIXIN, stomach warp; Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Radix Sanguisorbae: this product is the dry root of rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves; Bitter in the mouth, cold nature; Enter liver, large intestine channel; Cooling blood for hemostasis, removing toxic substances sore.
Radix Rehmanniae: the fresh rhizome that this product is scrophulariaceae rehmannia glutinosa plant; Sweet-bitter flavor, cold nature; Enter the heart, liver, kidney channel; Heat clearing away, removing heat from blood, to promote the production of body fluid.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is with Folium Artemisiae Argyi, Rhizoma Gastrodiae, Folium eucalypti globueli (Eucalyptus globulus Labill.) for monarch drug, dispersing cold for relieving pain, dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing; With Rhizoma Corydalis, Herba Houttuyniae, Herba Centellae, Herba Portulacae, Olibanum, Rhizoma Chuanxiong for ministerial drug, removing toxic substances and promoting subsidence of swelling, granulation promoting, wind-expelling pain-stopping; With Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae for adjuvant drug, enrich blood invigorate blood circulation, the pain relieving that helps digestion, removing toxic substances sore; With Radix Glycyrrhizae for making medicine, making all medicine coordinated, complementing each other, jointly reach the effects such as removing toxic substances and promoting subsidence of swelling, blood circulation promoting and blood stasis dispelling, granulation promoting skin, have very significant therapeutic effect to decubital ulcer.
Compared with prior art, Chinese medicine composition of the present invention has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the rotten poison of removing and granulation promoting skin in treatment decubital ulcer, dredging blood vessel meridians while the rotten poison of removing, the own metabolism of skin can be accelerated, toxin and antibacterial is enable to discharge the open sore part fast, further enhancing human body immunity power, strengthens the resistance to antibacterial, fungus, infects once again after avoiding wound healing simultaneously.And preparation method provided by the invention is simple and easy to do, applied widely, toxic and side effects is little, be easy to apply.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1
The embodiment of the present invention 1 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 25, Rhizoma Gastrodiae 10, Rhizoma Corydalis 4, Herba Houttuyniae 10, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15, Herba Centellae 8, Herba Portulacae 5, Olibanum 13, Rhizoma Chuanxiong 14, Radix Angelicae Sinensis 10, Fructus Lycii 6, Rhizoma Alpiniae Officinarum 8, Radix Ampelopsis 4, Radix Sanguisorbae 4, Radix Rehmanniae 10 and Radix Glycyrrhizae 6.
Preparation method:
S1: get Rhizoma Gastrodiae and clean, crushed after being dried, cross 80 mesh sieves, adding Rhizoma Gastrodiae coarse powder weight 5 times amount concentration is the ethanol of 65%, soak 6 hours, supersound extraction twice at 60 DEG C of temperature, each 40 minutes, supersonic frequency was 25kHz, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is the clear paste of 1.15, obtains Rhizoma Gastrodiae extract;
S2: get Folium Artemisiae Argyi, Rhizoma Corydalis, Herba Houttuyniae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Herba Portulacae, Olibanum, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae and be pulverized and mixed, the concentration adding above-mentioned coarse powder gross weight 6 times amount is 70% ethanol, soak 6 hours, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, is concentrated into the concentrated solution that relative density is 1.20 under 55 DEG C of conditions;
S3: the concentrated solution that the Rhizoma Gastrodiae extract obtained by step S1 and step S2 obtain mixes, and dry, pulverize, adds corresponding adjuvant, makes powder.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Rhizoma Gastrodiae 19, Rhizoma Corydalis 10, Herba Houttuyniae 15, Folium eucalypti globueli (Eucalyptus globulus Labill.) 22, Herba Centellae 25, Herba Portulacae 15, Olibanum 19, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Fructus Lycii 12, Rhizoma Alpiniae Officinarum 16, Radix Ampelopsis 8, Radix Sanguisorbae 8, Radix Rehmanniae 16 and Radix Glycyrrhizae 14.
Preparation method is as similar in embodiment 1, makes gel.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22, Rhizoma Gastrodiae 14, Rhizoma Corydalis 6, Herba Houttuyniae 12, Folium eucalypti globueli (Eucalyptus globulus Labill.) 18, Herba Centellae 18, Herba Portulacae 12, Olibanum 15, Rhizoma Chuanxiong 16, Radix Angelicae Sinensis 13, Fructus Lycii 8, Rhizoma Alpiniae Officinarum 14, Radix Ampelopsis 6, Radix Sanguisorbae 5, Radix Rehmanniae 14 and Radix Glycyrrhizae 10.
Preparation method is as similar in embodiment 1, makes ointment.
pharmacodynamic experiment
One, traditional Chinese medicine composition for treating Cavia porcellus decubital ulcer model test of the present invention
1. test material:
1.1 experimental animals: male guinea pig, body weight (275 ± 25) g, is provided by Nanjing Medical University's animal experimental center.
1.2 test drugs: the ointment for the treatment of decubital ulcer prepared by embodiment 3, MAYINGLONG MUSK HEMORRHOID UNGUENTUM, the accurate word of traditional Chinese medicines is: Z42021920, is purchased from Mayinglong Pharmaceutical Group Co., Ltd.
2. set up animal model: 36 Cavia porcelluss to be anaesthetized, skin degerming, fix with ventricumbent position, cutting near the left side of back spinal column the openning that is being about 3cm, implant through autoclaved 4.0cmx2.5cmx0.05cm stainless-steel sheet, sew up the incision, and bind up a wound, fix with binder.The postoperative single cage of Cavia porcellus is fed, and observes ld.With 4.0cm × 2.5cm × 1.0cm Magnet compressing wound surface (5h/d) after 24h, rest 12h circulates 1 time, total pressing time 10h, the formation area of record decubital ulcer and calibration grade.Divide cage separately by animal, feed and management condition consistent.
3. test method: Cavia porcellus decubital ulcer model forms latter 2nd day, and Cavia porcellus is divided into 3 groups at random, often organizes 12, is respectively normal group, positive controls and embodiment 3 groups, and each group process is as follows:
Normal group: after cleaning a wound with 0.9% sodium chloride, does not do other process;
Positive controls: after cleaning a wound with 0.9% sodium chloride, MAYINGLONG MUSK HEMORRHOID UNGUENTUM is applied to wound;
Embodiment 3 groups: after cleaning a wound with 0.9% sodium chloride, the ointment of the treatment decubital ulcer containing Folium Artemisiae Argyi embodiment 3 prepared is applied to wound;
Aforesaid operations smears 1 time every day, and medication judged effect after 14 days.
4. observation index:
According to decubital ulcer staging scale, cure as wound disappears, epidermis heals; Transfer well wound contraction 80% to, granulation is fresh, grows, edema extinction, and sepage is few; Invalid is wound contraction 50%, granulation undergrowth or have purulence sepage.
5. result of the test:
Treat patients with decubitus effect and healing days of table 1 Cavia porcellus compares
Note: compare with normal group, ▲ ▲p < 0.01.
As shown in Table 1, the ointment of the treatment decubital ulcer using the embodiment of the present invention 3 to prepare heals substantially at about 10 days wounds, and cure rate reaches 83.3%, and inefficiency is 0, proves that bedsore ointment prepared by the present invention has significant therapeutic effect to decubital ulcer.
Two, the clinical trial of Chinese medicine composition of the present invention
1. clinical study:
Choose the clinical volunteer patients that 120 examples suffer from decubital ulcer, wherein man 80 example, female 40 example, age 45-85 year, patient skin ulcer face diameter 1-30cm before the treatment, ulcerative stage 85 example, the deep ulcer phase 35 example; 120 routine patients are divided into 2 groups at random, are respectively treatment group and matched group, often organize 60 people.Two groups of Genders, age, severity extent and clinical manifestations, through statistical procedures no significant difference, have comparability.
2. trial drug and test method:
Treatment group: the ointment smearing treatment decubital ulcer prepared by the embodiment of the present invention 3, changes dressings 1 every day, each 0.52-1.04g, Continuous Observation 14 days.
Matched group: wound surface surrounding skin 75% alcohol disinfecting, wound surface 0.1% bromo geramine cleans, and wipes out slough as far as possible, then applies with Oleum Radix Arnebiae (Oleum Radix Lithospermi) gauze, and cover wrapping with sterile gauze, other are identical with observation group.
3. criterion of therapeutical effect:
" the Chinese medical disease Standardization of diagnosis and curative effect " implemented with reference to the State Administration of Traditional Chinese Medicines is also drafted in conjunction with the concrete condition of this research.
Recovery from illness: wound healing, without inflammatory exudation, skin ulcer reduction of area is little, has new granulation tissue to generate and epithelial tissue covering;
Effective: traumatic infection controls, and the little > 80% of skin ulcer reduction of area, have granulation tissue to generate, but wound does not heal completely;
Invalid: before and after treatment, wound contrast is not improved, and have no granulation growth, wound surface reduces < 40%.
4. result of the test:
Table 1 liang group Clinical efficacy comparison (%)
5. conclusion (of pressure testing):
Result of the test shows, and the ointment for the treatment of decubital ulcer prepared by the present invention has significant effect in treatment decubital ulcer, and cure rate reaches 83.3%, and total effective rate reaches 96.7%, is obviously better than the effect of matched group.Clinical test results shows, the ointment for the treatment of decubital ulcer prepared by the present invention has significant technical advantage in treatment decubital ulcer, can apply as clinical treatment decubital ulcer medicine.

Claims (6)

1. treat the Chinese medicine composition of decubital ulcer for one kind, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 25-30, Rhizoma Gastrodiae 10-19, Rhizoma Corydalis 4-10, Herba Houttuyniae 10-15, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-22, Herba Centellae 8-25, Herba Portulacae 5-15, Olibanum 13-19, Rhizoma Chuanxiong 14-20, Radix Angelicae Sinensis 10-15, Fructus Lycii 6-12, Rhizoma Alpiniae Officinarum 8-16, Radix Ampelopsis 4-8, Radix Sanguisorbae 4-8, Radix Rehmanniae 10-16 and Radix Glycyrrhizae 6-14.
2. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 25, Rhizoma Gastrodiae 10, Rhizoma Corydalis 4, Herba Houttuyniae 10, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15, Herba Centellae 8, Herba Portulacae 5, Olibanum 13, Rhizoma Chuanxiong 14, Radix Angelicae Sinensis 10, Fructus Lycii 6, Rhizoma Alpiniae Officinarum 8, Radix Ampelopsis 4, Radix Sanguisorbae 4, Radix Rehmanniae 10 and Radix Glycyrrhizae 6.
3. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Rhizoma Gastrodiae 19, Rhizoma Corydalis 10, Herba Houttuyniae 15, Folium eucalypti globueli (Eucalyptus globulus Labill.) 22, Herba Centellae 25, Herba Portulacae 15, Olibanum 19, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Fructus Lycii 12, Rhizoma Alpiniae Officinarum 16, Radix Ampelopsis 8, Radix Sanguisorbae 8, Radix Rehmanniae 16 and Radix Glycyrrhizae 14.
4. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 22, Rhizoma Gastrodiae 14, Rhizoma Corydalis 6, Herba Houttuyniae 12, Folium eucalypti globueli (Eucalyptus globulus Labill.) 18, Herba Centellae 18, Herba Portulacae 12, Olibanum 15, Rhizoma Chuanxiong 16, Radix Angelicae Sinensis 13, Fructus Lycii 8, Rhizoma Alpiniae Officinarum 14, Radix Ampelopsis 6, Radix Sanguisorbae 5, Radix Rehmanniae 14 and Radix Glycyrrhizae 10.
5. the Chinese medicine composition of the treatment decubital ulcer as described in any one of claim 1-4, is characterized in that: described Chinese medicine composition is made into powder, ointment or gel.
6. prepare a method for the Chinese medicine composition of the treatment decubital ulcer as described in any one of claim 1-4, it is characterized in that comprising the steps:
S1: get Rhizoma Gastrodiae and clean, crushed after being dried, cross 80-100 mesh sieve, adding Rhizoma Gastrodiae coarse powder weight 5-8 times amount concentration is the ethanol of 65-85%, soak 6-12 hour, supersound extraction twice at 60-70 DEG C of temperature, each 40-60 minute, supersonic frequency is 25-35kHz, filter, merging filtrate, during filtrate reduced in volume to 60 DEG C, relative density is the clear paste of 1.15-1.25, obtains Rhizoma Gastrodiae extract;
S2: get Folium Artemisiae Argyi, Rhizoma Corydalis, Herba Houttuyniae, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Herba Portulacae, Olibanum, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae and be pulverized and mixed, the concentration adding above-mentioned coarse powder gross weight 6-8 times amount is 70-80% ethanol, soak 6-12 hour, reflux, extract, 2-3 time, each 2-6 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, is concentrated into the concentrated solution that relative density is 1.20-1.25 under 55-60 DEG C of condition;
S3: the concentrated solution that the Rhizoma Gastrodiae extract obtained by step S1 and step S2 obtain mixes, and dry, pulverize, and to obtain final product.
CN201510654917.8A 2015-10-12 2015-10-12 Traditional Chinese medicine composition for treating bedsores and preparation method thereof Withdrawn CN105169183A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201510654917.8A CN105169183A (en) 2015-10-12 2015-10-12 Traditional Chinese medicine composition for treating bedsores and preparation method thereof
CN201610296314.XA CN105853866A (en) 2015-10-12 2015-10-12 Method for preparing Chinese herbal medicine composition for treating bedsore

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510654917.8A CN105169183A (en) 2015-10-12 2015-10-12 Traditional Chinese medicine composition for treating bedsores and preparation method thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610296314.XA Division CN105853866A (en) 2015-10-12 2015-10-12 Method for preparing Chinese herbal medicine composition for treating bedsore

Publications (1)

Publication Number Publication Date
CN105169183A true CN105169183A (en) 2015-12-23

Family

ID=54891931

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610296314.XA Withdrawn CN105853866A (en) 2015-10-12 2015-10-12 Method for preparing Chinese herbal medicine composition for treating bedsore
CN201510654917.8A Withdrawn CN105169183A (en) 2015-10-12 2015-10-12 Traditional Chinese medicine composition for treating bedsores and preparation method thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201610296314.XA Withdrawn CN105853866A (en) 2015-10-12 2015-10-12 Method for preparing Chinese herbal medicine composition for treating bedsore

Country Status (1)

Country Link
CN (2) CN105853866A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105561216A (en) * 2016-03-16 2016-05-11 烟台市蓝洋之草医药生物科技有限公司 Traditional Chinese medicine composition for treating bedsore and preparation method of traditional Chinese medicine composition
CN105727194A (en) * 2016-03-16 2016-07-06 烟台市蓝洋之草医药生物科技有限公司 Application of traditional Chinese medicine composition to preparation of medicines for treating bedsore

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383115A (en) * 2014-11-27 2015-03-04 崔合芳 Traditional Chinese medicine preparation for treating coronary heart disease and preparation method of traditional Chinese medicine preparation
CN104524204A (en) * 2014-12-15 2015-04-22 崔合芳 Traditional Chinese medicine preparation for treating wounds and malignant sores and preparation method of traditional Chinese medicine preparation
CN104547634A (en) * 2014-12-25 2015-04-29 广东聚智诚科技有限公司 Application of traditional Chinese medicinal composition for preparing medicine for treating bedsore
CN104547798A (en) * 2014-12-24 2015-04-29 广东聚智诚科技有限公司 Traditional Chinese medicine preparation for treating chronic enteritis and appendicitis and preparation method thereof
CN104644946A (en) * 2015-03-13 2015-05-27 王雪雁 Traditional Chinese medicine preparation for treating lower-limb ulcer and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104491213A (en) * 2014-12-09 2015-04-08 夏征梅 Traditional Chinese ointment for treating bedsores
CN104840659A (en) * 2015-05-13 2015-08-19 刘禾青 Traditional Chinese medicine unguent for curing decubital necrosis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104383115A (en) * 2014-11-27 2015-03-04 崔合芳 Traditional Chinese medicine preparation for treating coronary heart disease and preparation method of traditional Chinese medicine preparation
CN104524204A (en) * 2014-12-15 2015-04-22 崔合芳 Traditional Chinese medicine preparation for treating wounds and malignant sores and preparation method of traditional Chinese medicine preparation
CN104547798A (en) * 2014-12-24 2015-04-29 广东聚智诚科技有限公司 Traditional Chinese medicine preparation for treating chronic enteritis and appendicitis and preparation method thereof
CN104547634A (en) * 2014-12-25 2015-04-29 广东聚智诚科技有限公司 Application of traditional Chinese medicinal composition for preparing medicine for treating bedsore
CN104644946A (en) * 2015-03-13 2015-05-27 王雪雁 Traditional Chinese medicine preparation for treating lower-limb ulcer and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105561216A (en) * 2016-03-16 2016-05-11 烟台市蓝洋之草医药生物科技有限公司 Traditional Chinese medicine composition for treating bedsore and preparation method of traditional Chinese medicine composition
CN105727194A (en) * 2016-03-16 2016-07-06 烟台市蓝洋之草医药生物科技有限公司 Application of traditional Chinese medicine composition to preparation of medicines for treating bedsore

Also Published As

Publication number Publication date
CN105853866A (en) 2016-08-17

Similar Documents

Publication Publication Date Title
CN102091203B (en) External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof
CN105148156A (en) Traditional Chinese medicine composition for treating bedsores and preparation method thereof
CN103610854A (en) Traditional Chinese medicine (TCM) for treating allergic rhinitis
CN105169183A (en) Traditional Chinese medicine composition for treating bedsores and preparation method thereof
CN105327244A (en) Traditional Chinese medicine composition containing folium artemisiae argyi and used for treating bedsores and preparing method thereof
CN111840416A (en) Marrow-washing bone-setting liquid
CN105213609A (en) A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof
CN106421392A (en) Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel
CN109432203B (en) Pharmaceutical composition and traditional Chinese medicine raw material composition for treating non-lactation mastitis
CN113082089A (en) Traditional Chinese medicine ointment for treating skin allergy and preparation method thereof
CN105193996A (en) Traditional Chinese medicine composition for treating decubitus and preparation method of traditional Chinese medicine composition
CN105213922A (en) A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof
CN108498649B (en) Scorpion-astragalus root ointment
CN106729443A (en) A kind of Chinese medicine composition for swelling and pain relieving and preparation method thereof
CN106692821A (en) Traditional Chinese medicine preparation for treating neurosurgical postoperative headache
CN105169342A (en) Traditional Chinese medicine composition for treating eczema and preparation method thereof
CN105288401A (en) Pharmaceutical composition for treating bedsores and preparing method thereof
CN105267684A (en) Traditional Chinese medicine for treating chemotherapeutic phlebitis of tumor patients and preparation method thereof
CN104840826A (en) Traditional Chinese medicine preparation for treating aspiration site infection caused by bone marrow aspiration and preparation method thereof
CN105381366A (en) Traditional Chinese medicine composition for treating bedsores and preparing method thereof
CN105853843A (en) Pharmaceutical composition for clinical pediatric wound care and preparation method of pharmaceutical composition for clinical pediatric wound care
CN105125770A (en) Ointment for treating burn due to hot water or fire and preparation method
CN104524204A (en) Traditional Chinese medicine preparation for treating wounds and malignant sores and preparation method of traditional Chinese medicine preparation
CN113559209A (en) Chinese medicinal mixture for treating appendicitis and preparation method thereof
CN114588226A (en) A Chinese medicinal composition for treating fracture, and its preparation method

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20151223