CN105727194A - Application of traditional Chinese medicine composition to preparation of medicines for treating bedsore - Google Patents

Application of traditional Chinese medicine composition to preparation of medicines for treating bedsore Download PDF

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CN105727194A
CN105727194A CN201610190697.2A CN201610190697A CN105727194A CN 105727194 A CN105727194 A CN 105727194A CN 201610190697 A CN201610190697 A CN 201610190697A CN 105727194 A CN105727194 A CN 105727194A
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parts
radix
chinese medicine
medicine composition
curcumae
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刘学键
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Yantai Lanyangzhicao Pharmaceutical Biotechnology Co Ltd
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Yantai Lanyangzhicao Pharmaceutical Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to an application of a traditional Chinese medicine composition to preparation of medicines for treating bedsore. The traditional Chinese medicine composition comprises the following preparation raw materials: folium artemisiae argyi, heartleaf houttuynia herb, Danshen root, safflower, zedoray rhizome, Chinese gall, gypsum, platycodon root, wild honeysuckle flower, turmeric root-tuber, barbary wolfberry fruit, baical skullcap root and liquorice root. The traditional Chinese medicine composition has the functions of relieving swelling and pain, resisting bacteria and astringing sores and activating blood and removing stasis, has obvious curative effects on bedsore, has reliable effects, is wide in sources of components, is simple and convenient to prepare and has mild properties and low toxic and side effects.

Description

A kind of Chinese medicine composition purposes in the medicine of preparation treatment decubital ulcer
The application be indigo plant ocean, applicant Yantai City herbalist's medicine bio tech ltd propose application for a patent for invention (denomination of invention is: a kind of Chinese medicine composition treating decubital ulcer and preparation method thereof, application number is: 2016101472371, and the applying date is: on March 16th, 2016) divisional application.
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition purposes in the medicine of preparation treatment decubital ulcer.
Background technology
Decubital ulcer, also known as pressure ulcer, pressure ulcer, is due to the long-term pressurized of local organization, occurs continuous ischemia, anoxia, malnutrition to cause tissue fester's necrosis.Skin decubital ulcer is the problem of a universality in rehabilitation, nursing.There are about 60,000 people every year according to relevant bibliographical information and die from decubital ulcer complication.Decubital ulcer easily sends out crowd for each age group crowd being on one's back and old people throughout the year, and itself is just very painful owing to being ill and keep one's bed, and adds the torment of decubital ulcer, patient is suffered untold misery, especially nursing care of decubitus ulcer is improper, it also occur that various complication, even threat to life.
The clinical manifestation of decubital ulcer can be considered a series of activity of skin, and color depth excursion is white by red turn, and inorganization loses, and the degree of depth is destroyed and extended to muscle, joint capsule and skeleton.Its forming process is divided into erythema phase, blister phase and ulcerative stage three phase.The prevention of decubital ulcer is particularly important, mainly based on intensive care.
The measures such as the common method for the treatment of decubital ulcer is changed dressings for local, infra-red light irradiation, quiet Chinese medicinal ointment such as antibiotic, JINGWANHONG are smeared, often take effect slow, DeGrain, the unclean easy incrustation of rear wound surface smeared by ointment, incrustation not only limits granulation and epithelial growth, and easily infect under crust, impaired wound healing closes.Current clinical treatment decubital ulcer is but without ideal medicine, and part Western medicine prolonged application side effect is big, and the health for patient causes serious injury.Doctor trained in Western medicine surgical operation therapy is just for the patient being in a bad way, but it is big to have risk and opening, patient suffering greatly, costly, healing slow.Using antibiotic therapy decubital ulcer is only that traumatic infection is effective, but affects wound healing time, and there is certain side effect.
The traditional Chinese medical science is thought, decubital ulcer is that blood vessels are obstructed, and meridians intercept, and muscle muscles and bones is lost and supported, then corruption of bursting becomes skin ulcer, therefore should replenishing QI to invigorate the spleen, heat-clearing and toxic substances removing, convergence granulation promoting, reducing swelling and alleviating pain, antibacterial sore, blood circulation promoting and blood stasis dispelling because of prolonged illness deficiency of both QI and blood, extrusion position stagnation of QI-blood.According to theory of Chinese medical science, for the pathogeny of decubital ulcer, carry out dialectical composition of prescription, to reach the purpose for the treatment of both the principal and secondary aspects of a disease.
Chinese patent application 201310190138.8 discloses a kind of Chinese medicine composition treating decubital ulcer, and this Chinese medicine is made up of following raw material: Radix Angelicae Dahuricae 20-40 part, Oletum Trogopterori 4-20 part, Semen Ziziphi Spinosae 15-45 part, Limonitum 10-25 part, Lignum Aquilariae Resinatum 10-30 part, Radix Polygalae 5-35 part, Radix Astragali 40-60 part, Scorpio 10-30 part, Pericarpium Citri Reticulatae 3-15 part, prosperous fore-telling 5-25 part, Stigma Croci 5-20 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Glycyrrhizae 5-15 part, Cortex walnut 3-15 part, goa powder 5-15 part, Cinnabaris 1-5 part and Margarita powder 35-65 part.Better in treatment decubital ulcer curative effect, however this Chinese medicine composition prodrug complex, not easily to prepare, oral administration is also convenient without topical administration, and treatment specific aim is not high.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition purposes in the medicine of preparation treatment decubital ulcer, this Chinese medicine composition in treatment decubital ulcer, pointed strong, evident in efficacy, advantage that safety is high.
For realizing the purpose of the present invention, technical solution of the present invention is as follows:
What Chinese medicine composition of the present invention included following weight portion prepares raw material: Folium Artemisiae Argyi 21-29 part, Herba Houttuyniae 23-30 part, Radix Salviae Miltiorrhizae 16-22 part, Flos Carthami 14-19 part, Rhizoma Curcumae 18-23 part, Galla Chinensis 15-21 part, Gypsum Fibrosum 10-16 part, Radix Platycodonis 12-18 part, Flos Lonicerae 8-14 part, Radix Curcumae 10-17 part, Fructus Lycii 12-20 part, Radix Scutellariae 7-13 part and Radix Glycyrrhizae 6-13 part.
Further, what Chinese medicine composition of the present invention included following weight portion prepares raw material: Folium Artemisiae Argyi 29 parts, Herba Houttuyniae 30 parts, Radix Salviae Miltiorrhizae 22 parts, 19 parts of Flos Carthami, Rhizoma Curcumae 23 parts, Galla Chinensis 21 parts, 16 parts of Gypsum Fibrosum, Radix Platycodonis 18 parts, Flos Lonicerae 14 parts, Radix Curcumae 17 parts, Fructus Lycii 20 parts, Radix Scutellariae 13 parts and 13 parts of Radix Glycyrrhizae.
Further, what Chinese medicine composition of the present invention included following weight portion prepares raw material: Folium Artemisiae Argyi 21 parts, Herba Houttuyniae 23 parts, Radix Salviae Miltiorrhizae 16 parts, 14 parts of Flos Carthami, Rhizoma Curcumae 18 parts, Galla Chinensis 15 parts, 10 parts of Gypsum Fibrosum, Radix Platycodonis 12 parts, Flos Lonicerae 8 parts, Radix Curcumae 10 parts, Fructus Lycii 12 parts, Radix Scutellariae 7 parts and 6 parts of Radix Glycyrrhizae.
Further, what Chinese medicine composition of the present invention included following weight portion prepares raw material: Folium Artemisiae Argyi 25 parts, Herba Houttuyniae 27 parts, Radix Salviae Miltiorrhizae 19 parts, 16 parts of Flos Carthami, Rhizoma Curcumae 20 parts, Galla Chinensis 18 parts, 13 parts of Gypsum Fibrosum, Radix Platycodonis 15 parts, Flos Lonicerae 11 parts, Radix Curcumae 14 parts, Fructus Lycii 15 parts, Radix Scutellariae 10 parts and 9 parts of Radix Glycyrrhizae.
The present invention also provides for a kind of method of Chinese medicine composition preparing above-mentioned treatment decubital ulcer, comprise the following steps: weigh Folium Artemisiae Argyi, Herba Houttuyniae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Curcumae, Galla Chinensis, Gypsum Fibrosum, Radix Platycodonis, Flos Lonicerae, Radix Curcumae, Fructus Lycii, Radix Scutellariae and Radix Glycyrrhizae, by above-mentioned Chinese crude drug decontamination respectively, clean, dry, it is ground into coarse powder, mixing, the alcoholic solution that volumetric concentration is 40%-95% is added according to 4-9 times of coarse powder gross weight, reflux, extract, 2-3 time, return time is 2-5h, filter, merging filtrate, filtrate recycling ethanol, dry, it is ground into fine powder, cross 80-100 mesh sieve, make fine powder, obtain Chinese medicine composition of the present invention.
Further, in raw material of Chinese medicine medicine fine powder, add suitable adjuvant, make dosage form needed for clinic with modern Chinese medicine preparation common process, for instance cream, ointment, ointment, external spraying agent or paste etc..
The source of Chinese crude drug, nature and flavor used by Chinese prescription of the present invention, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort.Acrid in the mouth, hardship, warm in nature;Return liver,spleen,kidney warp;Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Herba Houttuyniae: this product is the dry aerial parts of saururaceae plant houttuynia cordata.Acrid in the mouth, cold nature;Return lung meridian;Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Bitter in the mouth, cold nature;GUIXIN, Liver Channel;Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Flos Carthami: this product is the dried floral of feverfew Flos Carthami.Acrid in the mouth, warm in nature;GUIXIN, Liver Channel;Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
Rhizoma Curcumae: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE.Acrid in the mouth, hardship, warm in nature;Return liver, spleen channel;Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
Galla Chinensis: this product is the insect gall on Anacardiaceae plant Fructus rhois chinensis, potanin sumac or red bran leaf, is mainly formed by melaphis chinensis Baker parasitism.Sour in the mouth, puckery, cold in nature;Return lung, large intestine, kidney channel;Astringing the lung pathogenic fire reducing, relieving diarrhea with astringents, arresting sweating stops blooding, removing dampness sore.
Gypsum Fibrosum: this product is Sulfates mineral anhydrites race Gypsum Fibrosum, main containing hydrous calcium sulfate.Sweet in the mouth, pungent, property Great Cold;Attach to the lung and stomach meridians;Clearing away heat-fire, relieving restlessness is quenched the thirst.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis.Bitter in the mouth, pungent, property is put down;Return lung meridian;Lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.
Flos Lonicerae: the flower that the dry flower of caprifoliaceae plant largeflower-like honeysuckle flower, Flos Lonicerae, Lonicera confusa or Lonicera fulvotnetosa Hsu et S. C. Cheng. Ms or band are just opened.Sweet in the mouth, cold in nature;Return lung, the heart, stomach warp;Thermal detoxification, dispelling wind and heat pathogens.
Radix Curcumae: this product is the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Acrid in the mouth, hardship, cold in nature;Return liver, the heart, lung meridian;Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.
Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum.Sweet in the mouth, property is put down;Return liver, kidney channel;Nourishing the liver and kidney, replenishing vital essence to improve eyesight.
Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae.Bitter in the mouth, cold in nature;Return lung, gallbladder, spleen, large intestine, small intestine meridian;Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down;GUIXIN, lung, spleen, stomach warp;Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The compatibility analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is according to the traditional Chinese medical science dialectical cognition to decubital ulcer, it then follows the compatibility theory of Chinese medicine, in order to make the preparation facilitating easy-to-use and stable curative effect, what enhance medical material makes consumption.This prescription is with Folium Artemisiae Argyi, Herba Houttuyniae and Rhizoma Curcumae for monarch drug, eliminating carbuncle evacuation of pus, circulation of qi promoting removing blood stasis;With Radix Salviae Miltiorrhizae, Flos Carthami and Galla Chinensis for ministerial drug, stasis-dispelling and pain-killing, removing dampness sore;With Gypsum Fibrosum, Radix Platycodonis, Flos Lonicerae, Radix Curcumae, Fructus Lycii with baikal skullcap root be used as the adjuvant medicine, the relieving restlessness that clears away heart-fire, eliminating fire and detoxication;With Radix Glycyrrhizae for making medicine, the coordinating the actions of various ingredients in a prescription property of medicine, all medicines coordinate, and complement each other, and synergism plays the effects such as sterilizing and itch-relieving, reducing swelling and alleviating pain, antibacterial sore and blood circulation promoting and blood stasis dispelling altogether, and treatment decubital ulcer is had very significant effect.
Compared with prior art, beneficial effect of the present invention is summarized as follows:
1. Chinese medicine composition of the present invention has the effects such as sterilizing and itch-relieving, reducing swelling and alleviating pain, antibacterial sore and blood circulation promoting and blood stasis dispelling in treatment decubital ulcer, also has that preparation technology is simple, an advantage such as good effect, side effect are low, taking convenience and application easy to spread.
2. compared with the chemotherapeutic agent of Current therapeutic decubital ulcer, Chinese medicine composition of the present invention is that natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, and medication effect is more preferably.
3. clinical trial results shows, traditional Chinese medicine composition for treating decubital ulcer of the present invention on average fully recovers efficiency up to 74%, average total effective rate is 92.67%, total effective rate apparently higher than comparison medicine 78%, therefore traditional Chinese medicine composition for treating decubital ulcer effect of the present invention is notable, can as the drug use of clinical treatment decubital ulcer, clinical generalization value is high.
Detailed description of the invention
The present invention is further described below by way of specific embodiment, the present invention is not limited only to following example, within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 Chinese medicine composition includes the Chinese crude drug of following weight portion: Folium Artemisiae Argyi 29 parts, Herba Houttuyniae 30 parts, Radix Salviae Miltiorrhizae 22 parts, 19 parts of Flos Carthami, Rhizoma Curcumae 23 parts, Galla Chinensis 21 parts, 16 parts of Gypsum Fibrosum, Radix Platycodonis 18 parts, Flos Lonicerae 14 parts, Radix Curcumae 17 parts, Fructus Lycii 20 parts, Radix Scutellariae 13 parts and 13 parts of Radix Glycyrrhizae.
Preparation method is as follows: weigh Folium Artemisiae Argyi, Herba Houttuyniae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Curcumae, Galla Chinensis, Gypsum Fibrosum, Radix Platycodonis, Flos Lonicerae, Radix Curcumae, Fructus Lycii, Radix Scutellariae and Radix Glycyrrhizae, by above-mentioned Chinese crude drug decontamination respectively, clean, dry, it is ground into coarse powder, mixing, adding volumetric concentration according to 5 times of coarse powder gross weight is the alcoholic solution of 50%, reflux, extract, 2 times, return time is 2h, filter, merging filtrate, filtrate recycling ethanol, dry, it is ground into fine powder, cross 80 mesh sieves, make fine powder, obtain Chinese medicine composition of the present invention, raw material of Chinese medicine medicine fine powder adds suitable adjuvant, spray is made with modern Chinese medicine preparation common process.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition includes the Chinese crude drug of following weight portion: Folium Artemisiae Argyi 21 parts, Herba Houttuyniae 23 parts, Radix Salviae Miltiorrhizae 16 parts, 14 parts of Flos Carthami, Rhizoma Curcumae 18 parts, Galla Chinensis 15 parts, 10 parts of Gypsum Fibrosum, Radix Platycodonis 12 parts, Flos Lonicerae 8 parts, Radix Curcumae 10 parts, Fructus Lycii 12 parts, Radix Scutellariae 7 parts and 6 parts of Radix Glycyrrhizae.
Preparation method is as follows: weigh Folium Artemisiae Argyi, Herba Houttuyniae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Curcumae, Galla Chinensis, Gypsum Fibrosum, Radix Platycodonis, Flos Lonicerae, Radix Curcumae, Fructus Lycii, Radix Scutellariae and Radix Glycyrrhizae, by above-mentioned Chinese crude drug decontamination respectively, clean, dry, it is ground into coarse powder, mixing, adding volumetric concentration according to 6 times of coarse powder gross weight is the alcoholic solution of 55%, , reflux, extract, 3 times, return time is 3h, filter, merging filtrate, filtrate recycling ethanol, dry, it is ground into fine powder, cross 80 mesh sieves, make fine powder, obtain Chinese medicine composition of the present invention, raw material of Chinese medicine medicine fine powder adds suitable adjuvant, ointment is made with modern Chinese medicine preparation common process.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine composition includes the Chinese crude drug of following weight portion: Folium Artemisiae Argyi 25 parts, Herba Houttuyniae 27 parts, Radix Salviae Miltiorrhizae 19 parts, 16 parts of Flos Carthami, Rhizoma Curcumae 20 parts, Galla Chinensis 18 parts, 13 parts of Gypsum Fibrosum, Radix Platycodonis 15 parts, Flos Lonicerae 11 parts, Radix Curcumae 14 parts, Fructus Lycii 15 parts, Radix Scutellariae 10 parts and 9 parts of Radix Glycyrrhizae.
Preparation method is embodiment 2 such as.
Embodiment 4
The embodiment of the present invention 4 Chinese medicine composition includes the Chinese crude drug of following weight portion: Folium Artemisiae Argyi 23, Herba Houttuyniae 26, Radix Salviae Miltiorrhizae 20, Flos Carthami 15, Rhizoma Curcumae 22, Galla Chinensis 16, Gypsum Fibrosum 13, Radix Platycodonis 14, Flos Lonicerae 12, Radix Curcumae 12, Fructus Lycii 16, Radix Scutellariae 10 and Radix Glycyrrhizae 10.
Preparation method is embodiment 2 such as.
Chinese medicine composition clinical pharrnacokinetics experimentation of the present invention
1, tcm diagnosis standard
With reference to the diagnostic criteria of decubital ulcer in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":
1) it is apt to occur in the apophysis such as tail sacrum, ridge, elbow ankle easily to suffer oppression and the position that rubs.
2) occurring brown erythema on skin, micro-swollen, purple dark edema then, necrosis is festered.
3) during secondary contamination, tissue necrosis is rapid, and pus is dripping, the concurrent core pain of corresponding site.
4) patient of the prolonged illness beds such as stupor, paralysis, fracture, large-area burns it is more common in.
2, experimenter's data
All experimenters are the clinical volunteers suffering from decubital ulcer, totally 200 example, wherein male 104 example, women 96 example, 58 years old mean age;All experimenters are divided into 4 groups at random, are numbered matched group, treatment A group, treatment B group and treatment C group respectively, often organize 50 people.Each group patient is no difference of science of statistics in age, sex, disease time, previously health history, ordinary circumstance etc., has comparability.
3, drug data
Matched group: Moschus recuperating depleted YANG cream, the quasi-word Z23021485 of traditional Chinese medicines, Pharmaceutical Factory No.6, Harbin Pharmaceutical Group.
Treatment A group: the spray of the embodiment of the present invention 1 preparation.
Treatment B group: the ointment of the embodiment of the present invention 2 preparation.
Treatment C group: the ointment of the embodiment of the present invention 3 preparation.
4, Therapeutic Method
First clean wound surface with normal saline or 3% hydrogen peroxide, then paste Moschus recuperating depleted YANG cream in affected part or smear ointment of the present invention, or spray of the present invention of spraying, answer if any blister and puncture under aseptic condition, push epidermis aside, paste again after emptying bubble liquid, when changing dressings, as found, fester in injury, repastes and smears medicine, change dressings every day 1 time after should wiping pus away, within 10th, it is a course for the treatment of, after treating 1 course for the treatment of, judges curative effect.
5. efficacy assessment standard
With reference to the efficacy assessment standard of decubital ulcer in People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease Standardization of diagnosis and curative effect ":
Cure: brown erythema disappears, or the wound healing that festers.
Take a turn for the better: erythema does not disappear entirely, or the skin ulcer face slough that festers comes off, and granulation, skin ulcer face is gradually reduced.
Do not heal: the open sore part increases, fester more than.
6. clinical test results is in Table 1.
Table 1 is taken Chinese medicine composition of the present invention and is taken the observation of curative effect of routine medication decubital ulcer
This clinical trial matched group is the Moschus recuperating depleted YANG cream of conventional treatment decubital ulcer, it is compared with the treatment clinical effectiveness of Chinese medicine composition of the present invention, and result of the test illustrates that the evident in efficacy of Chinese medicine composition of the present invention is better than matched group medicine.Clinical testing data shows, the effect cure rate of matched group Drug therapy decubital ulcer reaches 66%;And traditional Chinese medicine composition for treating decubital ulcer effect of the present invention on average fully recovers efficiency up to 74%, average total effective rate is 92.67%, hence it is evident that higher than the total effective rate of comparison medicine 78%.Wherein, treating C group, namely the ointment curative effect of the embodiment of the present invention 3 preparation is the most notable, for highly preferred embodiment of the present invention.Clinical trial results proves that traditional Chinese medicine composition for treating decubital ulcer effect of the present invention is notable, can as the drug use of clinical treatment decubital ulcer, and clinical generalization value is high.

Claims (6)

1. a Chinese medicine composition treats the purposes in the medicine of decubital ulcer in preparation, it is characterized in that, what described Chinese medicine composition included following weight portion prepares raw material: Folium Artemisiae Argyi 21-29 part, Herba Houttuyniae 23-30 part, Radix Salviae Miltiorrhizae 16-22 part, Flos Carthami 14-19 part, Rhizoma Curcumae 18-23 part, Galla Chinensis 15-21 part, Gypsum Fibrosum 10-16 part, Radix Platycodonis 12-18 part, Flos Lonicerae 8-14 part, Radix Curcumae 10-17 part, Fructus Lycii 12-20 part, Radix Scutellariae 7-13 part and Radix Glycyrrhizae 6-13 part.
2. the Chinese medicine composition as claimed in claim 1 purposes in the medicine of preparation treatment decubital ulcer, it is characterized in that, what described Chinese medicine composition included following weight portion prepares raw material: Folium Artemisiae Argyi 29 parts, Herba Houttuyniae 30 parts, Radix Salviae Miltiorrhizae 22 parts, 19 parts of Flos Carthami, Rhizoma Curcumae 23 parts, Galla Chinensis 21 parts, 16 parts of Gypsum Fibrosum, Radix Platycodonis 18 parts, Flos Lonicerae 14 parts, Radix Curcumae 17 parts, Fructus Lycii 20 parts, Radix Scutellariae 13 parts and 13 parts of Radix Glycyrrhizae.
3. the Chinese medicine composition as claimed in claim 1 purposes in the medicine of preparation treatment decubital ulcer, it is characterized in that, what described Chinese medicine composition included following weight portion prepares raw material: Folium Artemisiae Argyi 21 parts, Herba Houttuyniae 23 parts, Radix Salviae Miltiorrhizae 16 parts, 14 parts of Flos Carthami, Rhizoma Curcumae 18 parts, Galla Chinensis 15 parts, 10 parts of Gypsum Fibrosum, Radix Platycodonis 12 parts, Flos Lonicerae 8 parts, Radix Curcumae 10 parts, Fructus Lycii 12 parts, Radix Scutellariae 7 parts and 6 parts of Radix Glycyrrhizae.
4. the Chinese medicine composition as claimed in claim 1 purposes in the medicine of preparation treatment decubital ulcer, it is characterized in that, what described Chinese medicine composition included following weight portion prepares raw material: Folium Artemisiae Argyi 25 parts, Herba Houttuyniae 27 parts, Radix Salviae Miltiorrhizae 19 parts, 16 parts of Flos Carthami, Rhizoma Curcumae 20 parts, Galla Chinensis 18 parts, 13 parts of Gypsum Fibrosum, Radix Platycodonis 15 parts, Flos Lonicerae 11 parts, Radix Curcumae 14 parts, Fructus Lycii 15 parts, Radix Scutellariae 10 parts and 9 parts of Radix Glycyrrhizae.
5. the purposes in the medicine of preparation treatment decubital ulcer of the Chinese medicine composition as described in any one of claim 1-4, it is characterised in that: described Chinese medicine composition is cream, ointment, ointment, external spraying agent or paste.
6. the purposes in the medicine of preparation treatment decubital ulcer of the Chinese medicine composition as described in any one of claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises the following steps: weigh Folium Artemisiae Argyi, Herba Houttuyniae, Radix Salviae Miltiorrhizae, Flos Carthami, Rhizoma Curcumae, Galla Chinensis, Gypsum Fibrosum, Radix Platycodonis, Flos Lonicerae, Radix Curcumae, Fructus Lycii, Radix Scutellariae and Radix Glycyrrhizae, by above-mentioned Chinese crude drug decontamination respectively, clean, dry, it is ground into coarse powder, mixing, the alcoholic solution that volumetric concentration is 40%-95% is added according to 4-9 times of coarse powder gross weight, reflux, extract, 2-3 time, return time is 2-5h, filter, merging filtrate, filtrate recycling ethanol, dry, it is ground into fine powder, cross 80-100 mesh sieve, make fine powder, obtain Chinese medicine composition of the present invention.
CN201610190697.2A 2016-03-16 2016-03-16 Application of traditional Chinese medicine composition to preparation of medicines for treating bedsore Withdrawn CN105727194A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102861151A (en) * 2012-10-24 2013-01-09 牟静 Traditional Chinese medicine compound for treating bedsores
CN105169183A (en) * 2015-10-12 2015-12-23 临沂草之美医药科技有限公司 Traditional Chinese medicine composition for treating bedsores and preparation method thereof
CN105213609A (en) * 2015-09-30 2016-01-06 罗奕珺 A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102861151A (en) * 2012-10-24 2013-01-09 牟静 Traditional Chinese medicine compound for treating bedsores
CN105213609A (en) * 2015-09-30 2016-01-06 罗奕珺 A kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof
CN105169183A (en) * 2015-10-12 2015-12-23 临沂草之美医药科技有限公司 Traditional Chinese medicine composition for treating bedsores and preparation method thereof

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Application publication date: 20160706