CN106421392A - Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel - Google Patents
Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel Download PDFInfo
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- CN106421392A CN106421392A CN201610941004.9A CN201610941004A CN106421392A CN 106421392 A CN106421392 A CN 106421392A CN 201610941004 A CN201610941004 A CN 201610941004A CN 106421392 A CN106421392 A CN 106421392A
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Abstract
The invention discloses a traditional Chinese medicinal gel for treating bedsore and a preparation method of the traditional Chinese medicinal gel. The raw materials of the traditional Chinese medicinal gel comprise a traditional Chinese medicinal composition and a gel preparation; the traditional Chinese medicinal composition of the traditional Chinese medicinal gel is based on basic theories of traditional Chinese medicine, has a good synergistic effect, and has the effects of clearing heat, detoxifying, promoting blood circulation, promoting tissue regeneration, sterilizing and removing rot; medicines are combined with a gel matrix, so that the pharmacological activity and the advantages of the traditional Chinese medicinal gel are fully played; the rot is removed, blood vessels and meridians are dredged, and meanwhile, skin metabolism and wound healing can be promoted; the resistance to bacteria and fungi is enhanced; the wound healing is promoted; a wound is prevented from being re-infected after being healed; the traditional Chinese medicinal gel is smeared on the surface of the wound, and is convenient to use, high in compliance and good in treatment effect.
Description
Technical field
The invention belongs to Chinese medicine and field of traditional Chinese, more particularly, to a kind of Chinese medicine gel treating decubital ulcer and its preparation
Method.
Background technology
Decubital ulcer (decubitus)（Also known as pressure ulcer, pressure ulcer）It is because local organization is pressurized for a long time, occur persistently to lack
Blood, anoxia, malnutrition and cause skin and subcutaneous tissue ischemia that vesicle, ulcer or gangrene occur.Its forming process is divided into red
Speckle phase, blister phase and ulcerative stage three phase.The traditional Chinese medical science be referred to as " bed-sore ", be the long-term bed because prolonged illness QI and blood is lost greatly, local compression so that
Vim and vigour running is not normal, and meridians block, caused by being difficult flourish skin.In general, long-term bed, have bad physiques, stand up inconvenience and limbs
Insensitive person is susceptible to suffer from decubital ulcer, is clinically more common in following three class patients:1. stupor and paralytic.2. it is unable to leave the bed, body constitution
Weak patient.3. the patient fixing for a long time after fracturing or lying in bed.According to relevant document report there are about every year 60000 people die from decubital ulcer and
Cause complication.
Compared with Chinese patent medicine, during traditional doctor trained in Western medicine dressing more than application disinfectant or antibiotic although can effectively control
Antibacterial, but also inevitably inhibit the health regeneration of wound surface cell, thus leading to wound healing very slow, protracted inflammation is not
More, the live and work of impact patient.
The traditional Chinese medical science thinks, decubital ulcer is due to excessive rest on bed impairing QI, the deficiency of vital energy and hematogenous blockage；Outward because somatotopic is continuously subject to for a long time
Compressing and friction, lead to blood stasis due to qi deficiency, local failure of skin and muscle to be nourished, skin and flesh necrosis forms.The main principle for the treatment of by Chinese herbs decubital ulcer is clear
Thermal detoxification, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, promote slough to discharge, and accelerate tissue growth healing, promote wound surface surrounding tissue
Microcirculation, putrefaction-removing granulation-promoting, automatically repair, normal tissue has no side effect, filling wound sinus tract and lacuna, prevent wound from subsiding sense
Dye, mitigates patient mental and somatic pain.
Chinese patent application 201510675028.X discloses a kind of Chinese medicine composition for treating decubital ulcer and its preparation
Method, this Chinese medicine composition includes the preparing raw material of following parts by weight：Folium Artemisiae Argyi 20-30, Herba Viticis Cannabifoliae 18-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 16-
25th, Herba Centellae 15-20, Catechu 12-20, Rhizoma Chuanxiong 10-20, Radix Angelicae Sinensis 10-15, Rhizoma Alpiniae Officinarum 8-16, Radix Ampelopsis 5-12, Radix Sanguisorbae
5-15 and Radix Glycyrrhizae 5-12.This ointment has certain curative effect in terms for the treatment of decubital ulcer, but this Drug therapy decubital ulcer course for the treatment of is long,
Cure rate only has 78.5%, and effect is not too superior, and the present invention does not provide the preparation method of the formulation application form of determination yet, no
Beneficial to Clinical practice.Rancid abnormal flavour is occurred to fail substantially to cover for the decubital ulcer having.
Content of the invention
Medicine in order to solve to treat decubital ulcer in prior art has that healing is slow, treatment time length and fail to cover decubital ulcer rotten
Smell, it is an object of the invention to provide a kind of treat Chinese medicine gel of decubital ulcer and preparation method thereof, to solve above-mentioned asking
Topic.
To achieve these goals, the present invention adopts the following technical scheme that：
The Chinese medicine gel for the treatment of decubital ulcer, its constitutive material is made up of 7%-9% Chinese medicine composition and 91%-93% gel forming agent,
The constitutive material weight portion of Chinese medicine composition is：Nidus Vespae 20-30, Echinacea 15-30, Sanguis Draxonis 15-30, Radix Notoginseng 15-25, long-pending
The careless 15-20 of snow, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Pollen Typhae 10-20, Margarita 10-15, Borneolum Syntheticum 5-15, plaster of paris 5-15, Radix Trichosanthis 5-15,
Spina Gleditsiae 5-15, Radix rhamni crenatae 5-15, Squama Maniss 5-10 and Rhizoma Coptidis 5-10；The constitutive material percentage by weight of gel forming agent
For：Carbomer 1.0-1.5%, propylene glycol 15-20%, sodium hydroxide 0.5-0.7%, tween 80 0.8-1.2%, hyaluronic acid
1.8-2.2%, silicone 4-6%, different ceteth -20 1-3%, hydantoin 0.1-0.3%, benzalkonium chloride 0.013-
0.018%th, Herba Lysimachiae foenum-graeci quintessence oil 0.04-0.06%, agilawood essential oil 0.04-0.06%, remaining forms for purified water.
The constitutive material weight portion of described Chinese medicine composition is：Nidus Vespae 20, Echinacea 15, Sanguis Draxonis 15, Radix Notoginseng 15, long-pending
Snow grass 15, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Pollen Typhae 10, Margarita 10, Borneolum Syntheticum 5, plaster of paris 5, Radix Trichosanthis 5, Spina Gleditsiae 5, Radix rhamni crenatae 5, Squama Maniss
5 and Rhizoma Coptidis 5.
The constitutive material weight portion of described Chinese medicine composition is：Nidus Vespae 15, Echinacea 25, Sanguis Draxonis 25, Radix Notoginseng 20, accumulated snow
Grass 18, the Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Pollen Typhae 15, Margarita 13, Borneolum Syntheticum 12, plaster of paris 12, Radix Trichosanthis 12, Spina Gleditsiae 12, Radix rhamni crenatae 12, Chuan Shan
First 8 and Rhizoma Coptidis 8.
The constitutive material weight portion of described Chinese medicine composition is：Nidus Vespae 30, Echinacea 25, Sanguis Draxonis 30, Radix Notoginseng 25, long-pending
Snow grass 20, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20, Pollen Typhae 20, Margarita 15, Borneolum Syntheticum 15, plaster of paris 15, Radix Trichosanthis 15, Spina Gleditsiae 15, Radix rhamni crenatae 15,
Squama Maniss 10 and Rhizoma Coptidis 10.
The constitutive material percentage by weight of described gel forming agent is：Carbomer 1.2%, propylene glycol 18%, hydroxide
Sodium 0.6%, tween 80 1.0%, hyaluronic acid 2%, silicone 5%, different ceteth -20 2%, hydantoin 0.2%,
Benzalkonium chloride 0.015 %, Herba Lysimachiae foenum-graeci quintessence oil 0.05%, agilawood essential oil 0.05%, remaining forms for purified water.
The constitutive material of the present invention is preferably made up of 8% Chinese medicine composition and 92% gel forming agent.
Described Chinese medicine composition preparation method such as following step：
Step 1：Weigh ingredients respectively by Chinese prescription, wash away impurity, pulverize respectively after being dried, cross 60-80 mesh sieve, standby
With；
Step 2：Take Nidus Vespae, Echinacea, Herba Centellae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Borneolum Syntheticum, Pollen Typhae, plaster of paris, Radix Trichosanthis, Spina Gleditsiae, multitude peppery
Root, Rhizoma Coptidis coarse powder, add the ethanol for 60-80% for the 30-45% volume fraction of coarse powder weight, reflux, extract, 2-3 time, filter,
Merging filtrate, filter vacuum is evaporated to surveys the concentrated solution that relative density is 1.25-1.35 under the conditions of 60 DEG C, obtain alcohol extraction
Concentrated solution；Retain residue；
Step 3：The water adding total amount 8-13 times amount in the residue of above-mentioned steps 2 soaks 0.5-1 hour, then decocts 2-3
Secondary, each 1-2 hour, filters and retains filtering residue, merging filtrate, filter vacuum is surveyed relatively close under the conditions of being evaporated to 60 DEG C
Spend the concentrated solution for 1.25-1.35, obtain water extracting liquid；
Step 4：Take Sanguis Draxonis, Margarita, Squama Maniss to break into impalpable powder, cross 150 mesh -200 mesh sieve, obtain mixing impalpable powder, standby；
Step 5：The alcohol extracting concentrate of the impalpable powder of above-mentioned steps 4 gained, the water extracting liquid of step 3 and step 2 is merged mixed
Even, it is vacuum dried at a temperature of 60 DEG C, after being dried, dry extract is pulverized, cross 120-200 mesh sieve, obtain final product.
The preparation method of the Chinese medicine gel for the treatment of decubital ulcer, including herein below：
Step 1, weighs 1.2% Carbomer, plus recipe quantity 85% purified water, soaks swelling, crosses 40 mesh sieves, allocates pH with sodium hydroxide
It is worth to 6.80, obtain Carbomer gel component；
Step 2, weighs 8% Chinese medicine composition, 18% propylene glycol, 1.0% tween 80,2% hyaluronic acid, 5% silicone, 2% different
Ceteth -20,0.2% hydantoin, 0.015 % benzalkonium chloride and remaining purified water, 60 DEG C of mixing and stirring, use hydrogen
Sodium oxide adjusts pH to 6.80, obtains principal agent component；
Step 3, slow for Carbomer colloid component is poured in principal agent component, 60 DEG C of heating, and high speed shear, during constantly stir
Mix and deaerate, be eventually adding 0.05% Herba Lysimachiae foenum-graeci quintessence oil, 0.05% agilawood essential oil, stir, deaerate, fill.
The source of component used, nature and flavor, return through and effect in Chinese medicine composition of the present invention：
Nidus Vespae：This product is Vespidae insecticide fruit hornet Polistes olivaceous（DeGeer）, Japanese long foot wasp
The nest of Polistes japonicus Saussure or different abdomen wasp Parapolybia varia Fabricius.Sweet, put down,
Return stomach.There is wind-dispelling, counteracting toxic substances, parasite killing, pain relieving, antianaphylactic effect.Treatment of ulcer toxic swelling, acute mastitis, scrofula, skin stubborn dermatitis,
Fungal infection of hand and foot etc..
Echinacea：Originate in a kind of Echinacea plant of North America and southern Canada, main currently as drug development
There are 3 kinds：Echinacea purpurea Moench（Echinacea purpurea, i.e. usually said Echinacea）, Echinacea angustifolia
（Echinacea augustifolia）With white Echinacea（Echinacen pallida）.It is used for treating scarlet in history
Heat, syphilis, malaria, septicemia and diphtheria.There is the effect of natural antibiotics.
Sanguis Draxonis：For the resin in babassu Sanguis Draxonis fruit and trunk.It mostly is Liliaceae Dracaena cochinchinensiss or card Pu
Stockaded village's Folium Dracaenae cambodianae resin.Gan Xian, puts down.Enter the heart, liver, spleen channel.There is promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation, sore.For controlling traumatic injury
Swell and ache, ecchymoma due to internal injury；Continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time.
Radix Notoginseng：Root for panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.Warm in nature, sweet in the mouth,
Slight bitter.There is dissipate stasis of blood hemostasis, subduing swelling and relieving pain.For various inside and outside bleedings, chest and abdomen shouting pain, tumbling and swelling.
Herba Centellae：For dicotyledon Umbelliferae Umbelliferae Herba Centellae Centella asiatica (L.)
Urban is dried herb or whole herb with root.Cold in nature, bitter is pungent.Enter liver, spleen, kidney channel.Effect is heat-clearing and toxic substances removing, inducing diuresis and reducing edema.
Main disease to be treated has carbuncle sore tumefacting virus, injury from falling down, jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood.Herba Centellae can make skin become soft
Soft, help promote collagen protein in skin corium to be formed, have the effect making skin compact.Also assist in impaired organization healing and tight
Real skin.The close connection between epidermis and corium can be promoted, the increase of adipose cell can be suppressed again, prevent hydroderma,
Occur fat.
The Pseudobulbus Bletillae (Rhizoma Bletillae)：For orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata（Thunb.）Reichb. the dry tuber of f..Bitter,
Sweet, puckery, it is slightly cold.Return lung, liver, stomach.There is astringing to arrest bleeding, detumescence and promoting granulation.For traumatic hemorrhage, sore swollen toxin, chapped skin；
Pulmonary tuberculosis hemoptysis, hemoptysis is spitted blood, ulcer haemorrhage.
Pollen Typhae：For Typhaceae vegetation water turbid Herba Typhae Typha angustifolia L., typha orientalises Typha
Orientalis Presl or the dry pollen of congener.Sweet, put down, Return liver, pericardium channel.There is hemostasis, blood stasis dispelling, treating stranguria.With
In haematemesis, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, closed dysmenorrhea, gastral cavity abdomen twinge, tumbling and swelling, blood strangury and dry pain.
Margarita：For Pteriidae animal Pteria martensii Dunker Pteria martensii（Dunker）, Unionidae animal jib
Freshwater mussel Hyriopsis cumingii（Lea）Or cristaria plicata Cristaria plicata（Leach）Pierced Deng bivalve
Swash the Margarita being formed.Sweet, salty, tremble with fear.GUIXIN, Liver Channel.There is arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation.For insomnia of palpitating with fear,
Skin infection is not held back, infantile convulsion epilepsy, and mesh gives birth to nebula.
Borneolum Syntheticum：Divide BORNEOLUM SYNTHETICUM and Blumeae preparatum Tabellae two class.BORNEOLUM SYNTHETICUM is with Oleum Terebinthinae, Camphora etc. for raw material through being chemically synthesized
Borneolum Syntheticum；Pungent, bitter, it is slightly cold.GUIXIN, spleen, lung meridian.There is inducing resuscitation of having one's ideas straightened out, clearing away heat to alleviate pain.Faint for calentura coma, convulsion, middle wind-phlegm
Faint, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus are suppurated.
（Forging）Gypsum Fibrosum：For Sulfateses mineral anhydrite race Gypsum Fibrosum, master is containing hydrous calcium sulfate（CaSO4·2H2O）.Acrid in the mouth,
Sweet, cold in nature.Effect is：Gypsum Fibrosum heat clearing away is lowered the temperature, promoting the production of body fluid to quench thirst；Gypsum Fibrosum preparata heat clearing away, convergence, granulation promoting.
Radix Trichosanthis：For cucurbitaceous plant Fructus Trichosanthiss Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harmses
The dry root of Trichosan-thes rosthornii Herms.Sweet, slight bitter, is slightly cold.Return lung, stomach.There is clearing away heat and promoting production of body fluid,
Detumescence and apocenosis.For pyreticosis polydipsia, lung-heat type cough, Heat Diabetes, sore swollen toxin.
Spina Gleditsiae：Spina jujubae is dried for leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Acrid in the mouth, temperature, Return liver,
Stomach.There is detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus；External treatment scabies leprosy.
Squama Maniss：Scute for Manidae animal Squama Maniss Manis pentadactyla Linnaeus.Salty in the mouth, is slightly cold,
Return liver, stomach.There are stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, search wind and removing obstruction in channels.For amenorrhea abdominal mass, galactostasiss, carbuncle sore tumefacting virus, joint
Arthralgia pain, numbness contracture.
Radix rhamni crenatae:Root for Rhamnaceae plant rhamnus crenata sieb.et zucc. or root bark.Nature and flavor are bitter, put down, poisonous, enter Liver Channel.There is heat clearing away
Removing toxic substances；Parasite killing dampness removing.Cure mainly scabies, stubborn dermatitis furuncle, eczema, urticaria, leprosy dysentery head, traumatic injury.
Rhizoma Coptidis：For ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis
The dry rhizome of deltoidea C. Y. Cheng et Hsiao or Coptis Teeta Wall Coptis teeta Wall..Bitter in the mouth, trembles with fear, returns
The heart, spleen, stomach, liver, gallbladder, large intestine channel.There is heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice,
Unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, blood-head tells nosebleed, conjunctival congestion, toothache, quench one's thirst, carbuncle swells furunculosis；External treatment eczema, eczema, ear
Suppurate in road.
Lignum Aquilariae Resinatum：For Isolated From Thymelaeaceae Species Lignum Aquilariae Resinatum Aquilaria sinensis（Lour.）Gilg contains the wood of resin
Material.Acrid in the mouth, hardship, tepor.There is promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For chest and abdomen feeling of distension and oppression pain, gastrofrigid vomiting singultuss,
Kidney deficiency QI rising in reverse order dyspnea with rapid respiration, volatile oil component has anesthesia, calmness, pain relieving, Muscle relaxation.
Lavandula angustifolia：For Labiatae (Labiatae), the perennial evergreen dwarf shrub of lavandula angustifolia genus (Lavandula).Tool
Have heat-clearing and toxic substances removing, scattered wind is antipruritic, can wind dispelling, calmness, eliminate flatulence, diarrhoea, stable neural, relieve pressure, anxiety can be made
Emotion fast relaxation, releases anxiety, helps fall asleep, and tool promotes appetite, effect of skin care skin Caring.
The prescription analysis of Chinese prescription of the present invention：Chinese prescription of the present invention is with Nidus Vespae, Echinacea, Sanguis Draxonis, Radix Notoginseng as monarch
Medicine, promoting blood circulation to remove blood stasis, hemostasia and promoting granulation, analgesic therapy sore；With Herba Centellae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Margarita, plaster of paris, Radix Trichosanthis, Radix rhamni crenatae and Spina Gleditsiae
For ministerial drug, heat-clearing and toxic substances removing, inducing diuresis and reducing edema, detumescence and apocenosis；With Squama Maniss, Rhizoma Coptidis as adjuvant drug, detumescence and apocenosis, search wind and removing obstruction in channels, carbuncle
Sore, heat clearing and damp drying, eliminating fire and detoxication；With lavandula angustifolia, Lignum Aquilariae Resinatum for making medicine, calmness, pain relieving, flesh pine, sedative action, make all medicine associations
With coordinating, complement each other, jointly reach removing toxic substances and promoting subsidence of swelling, blood circulation promoting and blood stasis dispelling, granulation promoting are calmed the nerves, fragrant putrefaction removing the effects such as, have ten to decubital ulcer
Divide significant therapeutic effect.
Beneficial effects of the present invention：
Compared with prior art, the Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, promoting blood circulation and detumescence, putrefaction removing in terms for the treatment of decubital ulcer
Granulation promoting and calmly ache the effect calmed the nerves, remove corruption malicious while dredging blood vessel meridians, the own physiological of trauma skin can be promoted
Metabolism, further enhances immunity of organisms simultaneously, strengthens the resistance to antibacterial, funguses, it is to avoid infect once again after wound healing,
And cicatrix is repaired.Its medicament gelling agent compositions, process that the present invention provides, applied widely, compliance is strong.
Specific embodiment
Chinese medicine and field of traditional Chinese related personnel should be understood that the technology disclosed in following examples represents the present inventor
The technology playing good action in the practice of the invention finding, however, can do in disclosed specific embodiments
Go out the change of many combinations, and still obtain same or analogous result, without deviating from the spirit of the present invention, scope and meaning.
Embodiment 1：
The embodiment of the present invention 1 Chinese medicine composition includes the preparing raw material of following parts by weight：Nidus Vespae 20, Echinacea 15, blood
Exhaust 15, Radix Notoginseng 15, Herba Centellae 15, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Pollen Typhae 10, Margarita 10, Borneolum Syntheticum 5, plaster of paris 5, Radix Trichosanthis 5, Spina Gleditsiae
5th, Radix rhamni crenatae 5, Squama Maniss 5, Rhizoma Coptidis 5.
Gel forming agent is by Carbomer 1.2%, propylene glycol 18%, sodium hydroxide 0.6%, tween 80 1.0%, hyalomitome
Acid 2%, silicone 5%, different ceteth -20 2%, hydantoin 0.2%, benzalkonium chloride 0.015 %, Herba Lysimachiae foenum-graeci quintessence oil
0.05%th, agilawood essential oil 0.05%, remaining forms for water.
A. the preparation method of Chinese medicine composition comprises following step：
Step 1：Weigh ingredients respectively by Chinese prescription, wash away impurity, pulverize respectively after being dried, cross 60-80 mesh sieve, standby
With；
Step 2：Take Nidus Vespae, Echinacea, Herba Centellae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Borneolum Syntheticum, Pollen Typhae, plaster of paris, Radix Trichosanthis, Spina Gleditsiae, multitude peppery
Root, Rhizoma Coptidis coarse powder, add the ethanol for 60-80% for the 30-45% volume fraction of coarse powder weight, reflux, extract, 2-3 time, mistake
Filter, merging filtrate, filter vacuum is evaporated to surveys the concentrated solution that relative density is 1.25-1.35 under the conditions of 60 DEG C, obtain alcohol
Carry concentrated solution；Retain residue.
Step 3：Described residue, adds the water of total amount 8-13 times amount to soak 0.5-1 hour, then decocts 2-3
Secondary, each 1-2 hour, filters and retains filtering residue, merging filtrate, filter vacuum is surveyed relatively under the conditions of being evaporated to 60 DEG C
Density is the concentrated solution of 1.25-1.35, obtains water extracting liquid；
Step 4：Take Sanguis Draxonis, Margarita, Squama Maniss to break into impalpable powder, cross 150 mesh -200 mesh sieve, obtain mixing impalpable powder, standby；
Step 5：Described impalpable powder, water extracting liquid and alcohol extracting concentrate are merged and mixes, carry out vacuum at a temperature of 60 DEG C
It is dried, after being dried, dry extract is pulverized, cross 120-200 mesh sieve, obtain final product Chinese medicine composition of the present invention.
B. the gel preparation method of Chinese medicine composition：
Step 1, weighs 1.2% Carbomer, plus recipe quantity 85% purified water, soaks swelling, crosses 40 mesh sieves, allocates pH with sodium hydroxide
It is worth to 6.80, obtain Carbomer gel component；
Step 2, takes 8% Chinese medicine composition, 18% propylene glycol, 1.0% tween 80,2% hyaluronic acid, 5% silicone, 2% different whale
Ceryl alcohol polyethers -20,0.2% hydantoin, 0.015 % benzalkonium chloride and remaining purified water, 60 DEG C of mixing and stirring, use hydrogen-oxygen
Change sodium and adjust pH to 6.80, obtain principal agent component；
Step 3, slow for Carbomer colloid component is poured in principal agent component, 60 DEG C of heating, and high speed shear, during constantly stir
Mix and deaerate, be eventually adding 0.05% Herba Lysimachiae foenum-graeci quintessence oil, 0.05% agilawood essential oil, stir, deaerate, fill.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition includes the preparing raw material of following parts by weight：Nidus Vespae 15, Echinacea 25, Sanguis Draxonis
25th, Radix Notoginseng 20, Herba Centellae 18, the Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Pollen Typhae 15, Margarita 13, Borneolum Syntheticum 12, plaster of paris 12, Radix Trichosanthis 12, Spina Gleditsiae
12nd, Radix rhamni crenatae 12, Squama Maniss 8 and Rhizoma Coptidis 8.
Gel forming agent is by Carbomer 1.2%, propylene glycol 18%, sodium hydroxide 0.6%, tween 80 1.0%, hyalomitome
Acid 2%, silicone 5%, different ceteth -20 2%, hydantoin 0.2%, benzalkonium chloride 0.015 %, Herba Lysimachiae foenum-graeci quintessence oil
0.05%th, agilawood essential oil 0.05%, remaining forms for water.
The preparation method of Chinese medicine composition is similar with the gel preparation method of Chinese medicine composition such as embodiment 1, Chinese medicine
Gel is made in combination.
Embodiment 3
The embodiment of the present invention 2 Chinese medicine composition includes the preparing raw material of following parts by weight：Nidus Vespae 30, Echinacea 25, blood
Exhaust 30, Radix Notoginseng 25, Herba Centellae 20, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20, Pollen Typhae 20, Margarita 15, Borneolum Syntheticum 15, plaster of paris 15, Radix Trichosanthis 15, soap
Fructus Gleditsia acupuncture 15, Radix rhamni crenatae 15, Squama Maniss 10 and Rhizoma Coptidis 10.
Gel forming agent is by Carbomer 1.2%, propylene glycol 18%, sodium hydroxide 0.6%, tween 80 1.0%, hyalomitome
Acid 2%, silicone 5%, different ceteth -20 2%, hydantoin 0.2%, benzalkonium chloride 0.015 %, Herba Lysimachiae foenum-graeci quintessence oil
0.05%th, agilawood essential oil 0.05%, remaining forms for water.
The preparation method of Chinese medicine composition is similar with the gel preparation method of Chinese medicine composition such as embodiment 1, Chinese medicine
Gel is made in combination.
The gel preparation clinical trial of Chinese medicine composition of the present invention：
1. clinical study
Choose 200 clinical volunteer patients suffering from decubital ulcer, wherein male 95, female 105, age 35-88 year, patient
Skin ulcer face diameter 1-30cm before the treatment, ulcerative stage 120, the deep ulcer phase 80；200 patients are randomly divided into
2 groups, respectively treatment group and matched group, every group of 100 people.Two groups of Genders, age, health, severity extents and face
Bed performance is statistically analyzed no significant difference, has comparability（P ＞ 0.5）.
2. trial drug and test method
Treatment group：Smear the Chinese medicine composition gelata of the present invention of the embodiment of the present invention 2 preparation, equivalent crude drug content is 8.0%
Crude drug/pipe, sleeps front dressing 1 time daily, strengthens basic nursing 2H and stands up 1 time, prevents wound surface pressurized, gel is applied in and cleans
Wound surface on, then with covered rearing with plastic film, immobilization with adhesive tape, Continuous Observation 10 days.
Matched group：Wound surface surrounding skin 75% alcohol disinfecting, wound surface is cleaned with 0.1% bromo geramine, wipes out necrosis as far as possible
Tissue, is then coated with Radix Arnebiae (Radix Lithospermi) oil gauze, covers wrapping with sterile gauze, other are identical with observation group.
3. criterion of therapeutical effect
Implement with reference to the State Administration of Traditional Chinese Medicines《Chinese medical disease Standardization of diagnosis and curative effect》And the concrete condition studied with reference to this drafts sight
Examine content.
Recovery from illness：Wound healing, no inflammatory exudation, skin ulcer reduction of area is little, have new granulation tissue generate and epithelial tissue cover or
Wound surface is formed a scab and is come off；
Effectively：Traumatic infection controls, and skin ulcer reduction of area is little, no secretions, has granulation tissue to generate, but wound does not heal completely；
Invalid：Before and after treatment, wound contrast is not improved, and has no that granulation grows, wound surface reduces or wound surface does not heal.
4. result of the test
1 liang of group Clinical efficacy comparison (%) of table
| Group | N | Recovery from illness（Rate） | Effectively（Rate） | Invalid（Rate） | Total effective rate（%） |
| Treatment group | 100 | 84（84.0%） | 10（10.0%） | 6（6.0%） | 94.0% |
| Matched group | 100 | 17（17.0%） | 53（53.0%） | 30（30.0%） | 70.0% |
5. conclusion (of pressure testing)
Result of the test shows, a kind of Chinese medicine composition treating decubital ulcer of present invention preparation and its gel preparation are in treatment decubital ulcer side
Face has significant effect, and cure rate reaches 84.0%, and total effective rate reaches 94.0% hence it is evident that being better than the effect of matched group, clinical
Result of the test shows, the Chinese medicine composition for the treatment of decubital ulcer of present invention preparation and its gel have significantly in terms for the treatment of decubital ulcer
Technical advantage and clinical efficacy, can as treatment decubital ulcer clinical medicine application.
Claims (8)
1. a kind of Chinese medicine gel treating decubital ulcer is it is characterised in that its constitutive material is by 7%-9% Chinese medicine composition and 91%-
93% gel forming agent forms, and the constitutive material weight portion of Chinese medicine composition is：Nidus Vespae 20-30, Echinacea 15-30, Sanguis Draxonis
15-30, Radix Notoginseng 15-25, Herba Centellae 15-20, Pseudobulbus Bletillae (Rhizoma Bletillae) 15-20, Pollen Typhae 10-20, Margarita 10-15, Borneolum Syntheticum 5-15, forging stone
Cream 5-15, Radix Trichosanthis 5-15, Spina Gleditsiae 5-15, Radix rhamni crenatae 5-15, Squama Maniss 5-10 and Rhizoma Coptidis 5-10；Gel forming agent
Constitutive material percentage by weight is：Carbomer 1.0-1.5%, propylene glycol 15-20%, sodium hydroxide 0.5-0.7%, tween 80
0.8-1.2%, hyaluronic acid 1.8-2.2%, silicone 4-6%, different ceteth -20 1-3%, hydantoin 0.1-
0.3%th, benzalkonium chloride 0.013-0.018%, Herba Lysimachiae foenum-graeci quintessence oil 0.04-0.06%, agilawood essential oil 0.04-0.06%, remaining is purification
Water forms.
2. the Chinese medicine gel of the treatment decubital ulcer according to claim 1 is it is characterised in that the group of described Chinese medicine composition
Become parts by weight of raw materials be：Nidus Vespae 20, Echinacea 15, Sanguis Draxonis 15, Radix Notoginseng 15, Herba Centellae 15, the Pseudobulbus Bletillae (Rhizoma Bletillae) 15, Pollen Typhae 10, Margarita
10th, Borneolum Syntheticum 5, plaster of paris 5, Radix Trichosanthis 5, Spina Gleditsiae 5, Radix rhamni crenatae 5, Squama Maniss 5 and Rhizoma Coptidis 5.
3. the Chinese medicine gel for the treatment of decubital ulcer according to claim 1 is it is characterised in that described Chinese medicine composition
Constitutive material weight portion is：Nidus Vespae 15, Echinacea 25, Sanguis Draxonis 25, Radix Notoginseng 20, Herba Centellae 18, the Pseudobulbus Bletillae (Rhizoma Bletillae) 18, Pollen Typhae 15, treasure
Pearl 13, Borneolum Syntheticum 12, plaster of paris 12, Radix Trichosanthis 12, Spina Gleditsiae 12, Radix rhamni crenatae 12, Squama Maniss 8 and Rhizoma Coptidis 8.
4. the Chinese medicine gel for the treatment of decubital ulcer according to claim 1 is it is characterised in that described Chinese medicine composition
Constitutive material weight portion is：Nidus Vespae 30, Echinacea 25, Sanguis Draxonis 30, Radix Notoginseng 25, Herba Centellae 20, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20, Pollen Typhae 20, treasure
Pearl 15, Borneolum Syntheticum 15, plaster of paris 15, Radix Trichosanthis 15, Spina Gleditsiae 15, Radix rhamni crenatae 15, Squama Maniss 10 and Rhizoma Coptidis 10.
5. the Chinese medicine gel of the treatment decubital ulcer according to claim 1 is it is characterised in that described gel forming agent
Constitutive material percentage by weight be：Carbomer 1.2%, propylene glycol 18%, sodium hydroxide 0.6%, tween 80 1.0%, transparent
Matter acid 2%, silicone 5%, different ceteth -20 2%, hydantoin 0.2%, benzalkonium chloride 0.015 %, Herba Lysimachiae foenum-graeci quintessence oil
0.05%th, agilawood essential oil 0.05%, remaining forms for purified water.
6. the Chinese medicine gel for the treatment of decubital ulcer according to claim 1 is it is characterised in that its constitutive material is preferably by 8%
Drug composition and 92% gel forming agent composition.
7. the Chinese medicine gel according to the arbitrary described treatment decubital ulcer of claim 1-4 is it is characterised in that described Chinese medicine composition
Thing preparation method such as following step：
Step 1：Weigh ingredients respectively by Chinese prescription, wash away impurity, pulverize respectively after being dried, cross 60-80 mesh sieve, standby
With；
Step 2：Take Nidus Vespae, Echinacea, Herba Centellae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Notoginseng, Borneolum Syntheticum, Pollen Typhae, plaster of paris, Radix Trichosanthis, Spina Gleditsiae, multitude peppery
Root, Rhizoma Coptidis coarse powder, add the ethanol for 60-80% for the 30-45% volume fraction of coarse powder weight, reflux, extract, 2-3 time, filter,
Merging filtrate, filter vacuum is evaporated to surveys the concentrated solution that relative density is 1.25-1.35 under the conditions of 60 DEG C, obtain alcohol extraction
Concentrated solution；Retain residue；
Step 3：The water adding total amount 8-13 times amount in the residue of above-mentioned steps 2 soaks 0.5-1 hour, then decocts 2-3
Secondary, each 1-2 hour, filters and retains filtering residue, merging filtrate, filter vacuum is surveyed relatively close under the conditions of being evaporated to 60 DEG C
Spend the concentrated solution for 1.25-1.35, obtain water extracting liquid；
Step 4：Take Sanguis Draxonis, Margarita, Squama Maniss to break into impalpable powder, cross 150 mesh -200 mesh sieve, obtain mixing impalpable powder, standby；
Step 5：The alcohol extracting concentrate of the impalpable powder of above-mentioned steps 4 gained, the water extracting liquid of step 3 and step 2 is merged mixed
Even, it is vacuum dried at a temperature of 60 DEG C, after being dried, dry extract is pulverized, cross 120-200 mesh sieve, obtain final product.
8. the preparation method of the Chinese medicine gel for the treatment of decubital ulcer as claimed in claim 1 is it is characterised in that include in following
Hold：
Step 1, weighs 1.2% Carbomer, plus recipe quantity 85% purified water, soaks swelling, crosses 40 mesh sieves, allocates pH with sodium hydroxide
It is worth to 6.80, obtain Carbomer gel component；
Step 2, weighs 8% Chinese medicine composition, 18% propylene glycol, 1.0% tween 80,2% hyaluronic acid, 5% silicone, 2% different
Ceteth -20,0.2% hydantoin, 0.015 % benzalkonium chloride and remaining purified water, 60 DEG C of mixing and stirring, use hydrogen
Sodium oxide adjusts pH to 6.80, obtains principal agent component；
Step 3, slow for Carbomer colloid component is poured in principal agent component, 60 DEG C of heating, and high speed shear, during constantly stir
Mix and deaerate, be eventually adding 0.05% Herba Lysimachiae foenum-graeci quintessence oil, 0.05% agilawood essential oil, stir, deaerate, fill.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524739A (en) * | 2018-06-26 | 2018-09-14 | 西安艾姆高分子材料有限公司 | A kind of gel agent for treating bedsore |
| CN113318263A (en) * | 2021-08-02 | 2021-08-31 | 北京欣康研医药科技有限公司 | Antibacterial dressing and preparation method thereof |
| CN115463157A (en) * | 2022-09-28 | 2022-12-13 | 广东省林业科学研究院 | A composition for treating skin injury |
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|---|---|---|---|---|
| CN101347559A (en) * | 2008-07-02 | 2009-01-21 | 刘彦宾 | Medicament for treating ulcer of skin |
| CN103462882A (en) * | 2013-09-02 | 2013-12-25 | 安徽新和成皖南药业有限公司 | Adapalene gelata and preparation method thereof |
| CN105148156A (en) * | 2015-10-19 | 2015-12-16 | 广东聚智诚科技有限公司 | Traditional Chinese medicine composition for treating bedsores and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347559A (en) * | 2008-07-02 | 2009-01-21 | 刘彦宾 | Medicament for treating ulcer of skin |
| CN103462882A (en) * | 2013-09-02 | 2013-12-25 | 安徽新和成皖南药业有限公司 | Adapalene gelata and preparation method thereof |
| CN105148156A (en) * | 2015-10-19 | 2015-12-16 | 广东聚智诚科技有限公司 | Traditional Chinese medicine composition for treating bedsores and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108524739A (en) * | 2018-06-26 | 2018-09-14 | 西安艾姆高分子材料有限公司 | A kind of gel agent for treating bedsore |
| CN113318263A (en) * | 2021-08-02 | 2021-08-31 | 北京欣康研医药科技有限公司 | Antibacterial dressing and preparation method thereof |
| CN115463157A (en) * | 2022-09-28 | 2022-12-13 | 广东省林业科学研究院 | A composition for treating skin injury |
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Application publication date: 20170222 |