CN105148156A - Traditional Chinese medicine composition for treating bedsores and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating bedsores and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating bedsores and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of argy wormwood leaf, 18-30 parts of negundo chastetree fruit, 16-25 parts of eucalyptus leaf, 15-20 parts of asiatic pennywort herb, 12-20 parts of catechu, 10-20 parts of Szechuan lovage rhizome, 10-15 parts of Chinese angelica, 8-16 parts of lesser galangal rhizome, 5-12 parts of Japanese ampelopsis, 5-15 parts of garden burnet root and 5-12 parts of licorice root. The traditional Chinese medicine provided by the invention is reasonable in formula and strong in synergistic action, has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, clearing corrosive toxins and promoting tissue and skin regeneration, can dredge blood vessels, channels and collaterals, can accelerate metabolism of skin to enable toxins and bacteria to be quickly discharged out of open parts of sores, and can further enhance the body immunity and improve resistance to bacteria and fungi, thereby avoiding re-infection after wound healing.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of decubital ulcer and preparation method thereof.
Background technology
Decubital ulcer has another name called pressure ulcer (pressure ulcer), is the normal phase pressurized of local organization, continuous ischemia, anoxia, malnutrition and cause local organization fester, downright bad, be one of clinical common complication.The traditional Chinese medical science is called " bed-sore ", is because prolonged illness QI and blood is lost greatly, long-term bed, local compression so that vim and vigour running not normal, meridians block, and are difficult caused by flourish skin, and as given treatment to not in time, meat rotten bone dew concurrent infection, causes septicemia time serious, cause death.
Compared with Chinese patent medicine, many application disinfectant or antibiotic when traditional doctor trained in Western medicine is changed dressings, although effectively can control antibacterial, but also inevitably inhibit the health regeneration of wound surface cell, thus causing wound healing slowly, protracted inflammation is not healed, and affects the live and work of patient.
The main principle for the treatment of by Chinese herbs decubital ulcer is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, promotes that slough is discharged, and accelerates granulation tissue growth, necrotic tissue cleaning is external, improve the microcirculation of wound surface surrounding tissue, increase regional flow, can promote that remaining epithelial cell tissues grows, putrefaction-removing granulation-promoting simultaneously, activate body endogenous debridement process, show as painless debridement, normal tissue has no side effect, and fills wound sinus tract and lacuna, prevents wound from subsiding, ease the pain, absorb wound exudate.
Chinese patent application 201510239732.0 discloses a kind of Chinese medicine ointment being used for the treatment of decubital ulcer, this ointment is obtained by following raw material: Cortex Phellodendri 10-12, Sanguis Draxonis 3-4, Radix Arnebiae (Radix Lithospermi) 2-4, Radix Astragali 8-10, Radix Angelicae Dahuricae 5-6, Rhizoma Atractylodis 2-4, Radix Angelicae Sinensis 8-10, Radix Codonopsis 4-5, Radix Ampelopsis 2-4, Olibanum (processed) 5-6, Myrrha 9-10, Rhizoma Chuanxiong 3-4, Radix Trichosanthis 2-4, Cornu Cervi Degelatinatum 6-7, Radix Paeoniae Alba 4-6, fry Squama Manis 3-4, fry Spina Gleditsiae 1-3, Caulis Sargentodoxae 6-8, Rhizoma Polygoni Cuspidati 4-5, Cortex Moutan 9-11, Folium Artemisiae Argyi 2-4, Rhizoma Coptidis (processed with wine) 4-5, Semen Strychni (processed) 8-10, succinum 2-4, Fructus Dracontomeli Duperreani leaf 2-4, and Herba Gelsemii Elegantis 1-3.This ointment has certain curative effect in treatment decubital ulcer, but this Drug therapy decubital ulcer is long for the course for the treatment of, and Chinese prescription is complicated, and treatment cost is high.
Summary of the invention
There is to solve in prior art the medicine for the treatment of decubital ulcer the shortcoming that healing is slow, treatment time is long and treatment cost is high, the object of the present invention is to provide a kind of Chinese medicine composition for the treatment of decubital ulcer, to solve the problem.Meanwhile, the present invention also provides the preparation technology of this Chinese medicine composition.
Chinese medicine composition of the present invention comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 20-30, Herba Viticis Cannabifoliae 18-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 16-25, Herba Centellae 15-20, Catechu 12-20, Rhizoma Chuanxiong 10-20, Radix Angelicae Sinensis 10-15, Rhizoma Alpiniae Officinarum 8-16, Radix Ampelopsis 5-12, Radix Sanguisorbae 5-15 and Radix Glycyrrhizae 5-12.Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 20, Herba Viticis Cannabifoliae 18, Folium eucalypti globueli (Eucalyptus globulus Labill.) 16, Herba Centellae 15, Catechu 12, Rhizoma Chuanxiong 10, Radix Angelicae Sinensis 10, Rhizoma Alpiniae Officinarum 8, Radix Ampelopsis 5, Radix Sanguisorbae 5 and Radix Glycyrrhizae 5.Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Herba Viticis Cannabifoliae 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25, Herba Centellae 20, Catechu 20, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Rhizoma Alpiniae Officinarum 16, Radix Ampelopsis 12, Radix Sanguisorbae 15 and Radix Glycyrrhizae 12.Further, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 24, Herba Viticis Cannabifoliae 25, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20, Herba Centellae 18, Catechu 15, Rhizoma Chuanxiong 16, Radix Angelicae Sinensis 12, Rhizoma Alpiniae Officinarum 12, Radix Ampelopsis 10, Radix Sanguisorbae 10 and Radix Glycyrrhizae 8.Accordingly, the preparation method of described Chinese medicine composition comprises the following steps:
S1: take ingredients respectively by Chinese prescription, washes away impurity, pulverizes respectively after drying, crosses 60-80 mesh sieve, for subsequent use;
S2: get Herba Viticis Cannabifoliae coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15 ~ 20L/h, extracting pressure is 15 ~ 20MPa, and extraction temperature is 40 ~ 60 DEG C, and extraction time is 1.5 ~ 2h, decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
S3: get Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Catechu, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae and Radix Glycyrrhizae coarse powder, merge the Herba Viticis Cannabifoliae residue described in S2, add the water soaking 0.5-1 hour of coarse powder total amount 8-13 times amount, then decoct 2-3 time, each 1-2 hour, filters and retains filtering residue, merging filtrate, filter vacuum surveys the concentrated solution that relative density is 1.25-1.35 under being evaporated to 60 DEG C of conditions, obtains water extracting liquid;
S4: adding medical material total amount 8-10 times amount volume fraction in the filtering residue described in S3 is the ethanol of 60-80%, reflux, extract, 2-3 time, filters, merging filtrate, filter vacuum surveys the concentrated solution that relative density is 1.25-1.35 under being evaporated to 60 DEG C of conditions, obtains alcohol extraction concentrated solution;
S5: described Herba Viticis Cannabifoliae extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 15L/h, material strip transfer rate is 26cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention; S6: add suitable adjuvant in the Chinese medicine composition described in S5, make preparation.Chinese medicine composition of the present invention can be made into the finished product preparation such as powder, ointment or gel, is convenient to patient and uses.
In Chinese medicine composition of the present invention component used source, nature and flavor, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Bitter in the mouth, warm in nature; Return liver,spleen,kidney warp; Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Herba Viticis Cannabifoliae: this product is Verenaceae deciduous plant Herba Viticis Cannabifoliae dried leaves; Mildly bitter flavor, pungent; Property is put down; Return lung meridian; To induce sweat removing dampness, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, pain relieving.Folium eucalypti globueli (Eucalyptus globulus Labill.): this product is the leaf for myrtle Eucalyptus globulus Labill; Bitter in the mouth, warm in nature; Return lung, stomach, spleen, Liver Channel; Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, killing parasites for relieving itching.
Herba Centellae: this product is the dry herb of samphire Herba Centellae; Bitter in the mouth, cold in nature; Return liver,spleen,kidney warp; Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.
Catechu: this product is the powdered extract that the branch of leguminous plant catechu or the branch and leaf of Maguireothamnus speciosus Uncaria gambier Roxb. are decocted juice and concentrated; Bitter and puckery flavor, cool in nature; Enter the heart, lung; Heat clearing away, reduce phlegm, stop blooding, help digestion, granulation promoting, analgesic therapy.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, warm in nature; Return liver, the heart, spleen channel; Enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Rhizoma Alpiniae Officinarum: this product is the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum; Acrid in the mouth, hot in nature; Return spleen, stomach warp; Warming stomach for dispelling cold, help digestion pain relieving.
Radix Ampelopsis: this product is the dried root of vitaceae Radix Ampelopsis; Bitter in the mouth, cold nature; GUIXIN, stomach warp; Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.
Radix Sanguisorbae: this product is the dry root of rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves; Bitter in the mouth, cold nature; Enter liver, large intestine channel; Cooling blood for hemostasis, removing toxic substances sore.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention: Chinese prescription of the present invention is with Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Herba Viticis Cannabifoliae for monarch drug, dispersing cold for relieving pain, dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing; With Herba Centellae, Catechu, Rhizoma Chuanxiong for ministerial drug, removing toxic substances and promoting subsidence of swelling, granulation promoting, wind-expelling pain-stopping; With Radix Angelicae Sinensis, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae for adjuvant drug, enrich blood invigorate blood circulation, the pain relieving that helps digestion, removing toxic substances sore; With Radix Glycyrrhizae for making medicine, making all medicine coordinated, complementing each other, jointly reach the effects such as removing toxic substances and promoting subsidence of swelling, blood circulation promoting and blood stasis dispelling, granulation promoting skin, have very significant therapeutic effect to decubital ulcer.
Compared with prior art, Chinese medicine composition of the present invention has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the rotten poison of removing and granulation promoting skin in treatment decubital ulcer, dredging blood vessel meridians while the rotten poison of removing, the own metabolism of skin can be accelerated, toxin and antibacterial is enable to discharge the open sore part fast, further enhancing human body immunity power, strengthens the resistance to antibacterial, fungus, infects once again after avoiding wound healing simultaneously.And preparation method provided by the invention is simple and easy to do, applied widely, toxic and side effects is little, be easy to apply.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
Embodiment 1
The embodiment of the present invention 1 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 20, Herba Viticis Cannabifoliae 18, Folium eucalypti globueli (Eucalyptus globulus Labill.) 16, Herba Centellae 15, Catechu 12, Rhizoma Chuanxiong 10, Radix Angelicae Sinensis 10, Rhizoma Alpiniae Officinarum 8, Radix Ampelopsis 5, Radix Sanguisorbae 5 and Radix Glycyrrhizae 5.
Preparation method
S1: take ingredients respectively by Chinese prescription, washes away impurity, pulverizes respectively after drying, crosses 60 mesh sieves, for subsequent use;
S2: get Herba Viticis Cannabifoliae coarse powder, be placed in supercritical carbon dioxide extraction apparatus, 30% volume fraction adding coarse powder weight is the ethanol of 60%, regulation and control carbon dioxide flow is 15L/h, extracting pressure is 15MPa, and extraction temperature is 40 DEG C, and extraction time is 2h, decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
S3: get Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Catechu, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae and Radix Glycyrrhizae coarse powder, merge the Herba Viticis Cannabifoliae residue described in S2, add the water soaking 1 hour of coarse powder total amount 13 times amount, then decoct 3 times, each 2 hours, filter and retain filtering residue, merging filtrate, filter vacuum surveys the concentrated solution that relative density is 1.25-1.35 under being evaporated to 60 DEG C of conditions, obtains water extracting liquid;
S4: adding medical material total amount 10 times amount volume fraction in the filtering residue described in S3 is the ethanol of 80%, reflux, extract, 3 times, filter, merging filtrate, filter vacuum surveys the concentrated solution that relative density is 1.25-1.35 under being evaporated to 60 DEG C of conditions, obtains alcohol extraction concentrated solution;
S5: described Herba Viticis Cannabifoliae extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 15L/h, material strip transfer rate is 26cm/min, after drying, dry extract is pulverized, cross 150 mesh sieves, obtain Chinese medicine composition of the present invention;
S6: add suitable adjuvant in the Chinese medicine composition described in S5, utilize modern general Chinese medicine preparation technology, S5 gained Chinese medicine composition is made ointment, and amounting to crude drug content is 7.53g crude drug/pipe.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30, Herba Viticis Cannabifoliae 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25, Herba Centellae 20, Catechu 20, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Rhizoma Alpiniae Officinarum 16, Radix Ampelopsis 12, Radix Sanguisorbae 15 and Radix Glycyrrhizae 12.Preparation method is as similar in embodiment 1, makes gel.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 24, Herba Viticis Cannabifoliae 25, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20, Herba Centellae 18, Catechu 15, Rhizoma Chuanxiong 16, Radix Angelicae Sinensis 12, Rhizoma Alpiniae Officinarum 12, Radix Ampelopsis 10, Radix Sanguisorbae 10 and Radix Glycyrrhizae 8.Preparation method is as similar in embodiment 1, makes powder.
pharmacodynamic experiment
one,traditional Chinese medicine composition for treating Cavia porcellus decubital ulcer model test of the present invention
1. test material:
1.1, experimental animal: male guinea pig, body weight (250 ± 50) g, is provided by Nanjing Medical University's animal experimental center.
1.2, test drug: Chinese medicine composition ointment of the present invention prepared by embodiment 1, MAYINGLONG MUSK HEMORRHOID UNGUENTUM, the accurate word of traditional Chinese medicines is: Z42021920, is purchased from Mayinglong Pharmaceutical Group Co., Ltd.
2. set up animal model: 45 Cavia porcelluss to be anaesthetized, skin degerming, fix with ventricumbent position, cutting near the left side of back spinal column the openning that is being about 3cm, implant through autoclaved 4.0cmx2.5cmx0.05cm stainless-steel sheet, sew up the incision, and bind up a wound, fix with binder.The postoperative single cage of Cavia porcellus is fed, and observes ld.4.0cmx2.5cmx1.0cm Magnet compressing wound surface (5h/d) after 24h, rest 12h circulates 1 time, total pressing time 10h, the formation area of record decubital ulcer and calibration grade.Divide cage separately by animal, feed and management condition consistent.
3. test method: Cavia porcellus decubital ulcer model forms latter 2nd day, Cavia porcellus is divided into 3 groups at random, is respectively normal group, positive controls and embodiment 1 group, each group process is as follows:
Normal group: after cleaning a wound with sterile saline, does not do other process;
Positive controls: after cleaning a wound with sterile saline, MAYINGLONG MUSK HEMORRHOID UNGUENTUM is applied to wound;
Embodiment 4 groups: after cleaning a wound with sterile saline, the Chinese medicine composition ointment of the present invention embodiment 1 prepared is applied to wound;
Aforesaid operations smears 1 time every day, and medication judged effect after 14 days.
4. observation index:
According to decubital ulcer staging scale, cure as wound disappears, epidermis heals; Transfer well wound contraction 80% to, granulation is fresh, grows, edema extinction, and sepage is few; Invalid is wound contraction 50%, granulation undergrowth or have purulence sepage.
5. result of the test
Treat patients with decubitus effect and healing days of table 1 Cavia porcellus compares
Note: compare with normal group,
△ △p < 0.01.
As shown in Table 1, the Chinese medicine composition ointment of the present invention using the embodiment of the present invention 1 to prepare heals substantially at about 10 days wounds, and cure rate reaches 73.33%, and inefficiency is 0, proves that bedsore ointment prepared by the present invention has significant therapeutic effect to decubital ulcer.
Two, the clinical trial of Chinese medicine composition of the present invention
1. clinical study
Choose the clinical volunteer patients that 140 examples suffer from decubital ulcer, wherein man 80 example, female 60 example, age 48-88 year, patient skin ulcer face diameter 1 ~ 30cm before the treatment, ulcerative stage 88 example, the deep ulcer phase 52 example; 140 routine patients are divided into 2 groups at random, are respectively treatment group and matched group, often organize 70 people.Two groups of Genders, age, severity extent and clinical manifestations, through statistical procedures no significant difference, have comparability.
2. trial drug and test method
Treatment group: smear Chinese medicine composition gelata of the present invention prepared by the embodiment of the present invention 2, amounting to crude drug content is 9.75g crude drug/pipe, changes dressings every day 1 time, each 0.52-1.04g, Continuous Observation 14 days.
Matched group: wound surface surrounding skin 75% alcohol disinfecting, wound surface 0.1% bromo geramine cleans, and wipes out slough as far as possible, then applies with Oleum Radix Arnebiae (Oleum Radix Lithospermi) gauze, and cover wrapping with sterile gauze, other are identical with observation group.
3. criterion of therapeutical effect
" the Chinese medical disease Standardization of diagnosis and curative effect " implemented with reference to the State Administration of Traditional Chinese Medicines is also drafted in conjunction with the concrete condition of this research.
Recovery from illness: wound healing, without inflammatory exudation, skin ulcer reduction of area is little, has new granulation tissue to generate and epithelial tissue covering;
Effective: traumatic infection controls, and the little >80% of skin ulcer reduction of area, have granulation tissue to generate, but wound does not heal completely;
Invalid: before and after treatment, wound contrast is not improved, and have no granulation growth, wound surface reduces <40%.
4. result of the test
Table 1 liang group Clinical efficacy comparison (%)
| Group | N | Recovery from illness (rate) | Effectively (rate) | Invalid (rate) | Total effective rate (%) |
| Treatment group | 70 | 55（78.5%） | 10（14.3%） | 5（7.1%） | 92.9% |
| Matched group | 70 | 20（28.6%） | 35（50.0%） | 15（21.4%） | 78.6% |
5. conclusion (of pressure testing)
Result of the test shows, and the Chinese medicine composition gelata for the treatment of decubital ulcer prepared by the present invention has significant effect in treatment decubital ulcer, and cure rate reaches 78.5%, and total effective rate reaches 92.9%, is obviously better than the effect of matched group.Clinical test results shows, the Chinese medicine composition gelata for the treatment of decubital ulcer prepared by the present invention has significant technical advantage in treatment decubital ulcer, can apply as clinical treatment decubital ulcer medicine.
Claims (6)
1. treat a Chinese medicine composition for decubital ulcer, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 20-30, Herba Viticis Cannabifoliae 18-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 16-25, Herba Centellae 15-20, Catechu 12-20, Rhizoma Chuanxiong 10-20, Radix Angelicae Sinensis 10-15, Rhizoma Alpiniae Officinarum 8-16, Radix Ampelopsis 5-12, Radix Sanguisorbae 5-15 and Radix Glycyrrhizae 5-12.
2. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 20, Herba Viticis Cannabifoliae 18, Folium eucalypti globueli (Eucalyptus globulus Labill.) 16, Herba Centellae 15, Catechu 12, Rhizoma Chuanxiong 10, Radix Angelicae Sinensis 10, Rhizoma Alpiniae Officinarum 8, Radix Ampelopsis 5, Radix Sanguisorbae 5 and Radix Glycyrrhizae 5.
3. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 30, Herba Viticis Cannabifoliae 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25, Herba Centellae 20, Catechu 20, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Rhizoma Alpiniae Officinarum 16, Radix Ampelopsis 12, Radix Sanguisorbae 15 and Radix Glycyrrhizae 12.
4. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 24, Herba Viticis Cannabifoliae 25, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20, Herba Centellae 18, Catechu 15, Rhizoma Chuanxiong 16, Radix Angelicae Sinensis 12, Rhizoma Alpiniae Officinarum 12, Radix Ampelopsis 10, Radix Sanguisorbae 10 and Radix Glycyrrhizae 8.
5. the Chinese medicine composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described Chinese medicine composition is made into powder, ointment or gel.
6. the preparation method of the Chinese medicine composition of the treatment decubital ulcer as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following step: S1: take ingredients respectively by Chinese prescription, wash away impurity, pulverize respectively after drying, cross 60-80 mesh sieve, for subsequent use;
S2: get Herba Viticis Cannabifoliae coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15 ~ 20L/h, extracting pressure is 15 ~ 20MPa, and extraction temperature is 40 ~ 60 DEG C, and extraction time is 1.5 ~ 2h, decompression separation obtains Herba Viticis Cannabifoliae extract, retains Herba Viticis Cannabifoliae residue;
S3: get Folium Artemisiae Argyi, Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae, Catechu, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae and Radix Glycyrrhizae coarse powder, merge the Herba Viticis Cannabifoliae residue described in S2, add the water soaking 0.5-1 hour of coarse powder total amount 8-13 times amount, then decoct 2-3 time, each 1-2 hour, filters and retains filtering residue, merging filtrate, filter vacuum surveys the concentrated solution that relative density is 1.25-1.35 under being evaporated to 60 DEG C of conditions, obtains water extracting liquid;
S4: adding medical material total amount 8-10 times amount volume fraction in the filtering residue described in S3 is the ethanol of 60-80%, reflux, extract, 2-3 time, filters, merging filtrate, filter vacuum surveys the concentrated solution that relative density is 1.25-1.35 under being evaporated to 60 DEG C of conditions, obtains alcohol extraction concentrated solution;
S5: described Herba Viticis Cannabifoliae extract, water extracting liquid and alcohol extraction concentrated solution are merged mixing, vacuum belt type drying is carried out at 60 DEG C of temperature, drying pressure is-0.09MPa, charging rate is 15L/h, material strip transfer rate is 26cm/min, after drying, dry extract is pulverized, cross 100-200 mesh sieve, obtain Chinese medicine composition of the present invention; S6: add suitable adjuvant in the Chinese medicine composition described in S5, make preparation.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535214A (en) * | 2016-01-31 | 2016-05-04 | 王晓燕 | Traditional Chinese medicine composition for rapidly treating bed sore |
| CN105560836A (en) * | 2016-01-28 | 2016-05-11 | 郭洪平 | Traditional Chinese medicine composition for rapidly treating bedsores |
| CN106421392A (en) * | 2016-11-02 | 2017-02-22 | 福元药业股份有限公司 | Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel |
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| CN101244221A (en) * | 2007-02-13 | 2008-08-20 | 汪建国 | Composition for external application and preparation method |
| CN104324338A (en) * | 2014-11-29 | 2015-02-04 | 山东省立医院 | Nursing patch for bedsore |
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2015
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| CN101244221A (en) * | 2007-02-13 | 2008-08-20 | 汪建国 | Composition for external application and preparation method |
| CN104324338A (en) * | 2014-11-29 | 2015-02-04 | 山东省立医院 | Nursing patch for bedsore |
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| 周毓萍等: "佛手活络酊剂防治压疮的作用", 《中国临床康复》 * |
| 封志英: "褥疮的中医药治疗近况", 《护理研究》 * |
| 胡灏等: "创面灵治疗骶尾部Ⅲ期褥疮21例", 《世界中医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560836A (en) * | 2016-01-28 | 2016-05-11 | 郭洪平 | Traditional Chinese medicine composition for rapidly treating bedsores |
| CN105535214A (en) * | 2016-01-31 | 2016-05-04 | 王晓燕 | Traditional Chinese medicine composition for rapidly treating bed sore |
| CN106421392A (en) * | 2016-11-02 | 2017-02-22 | 福元药业股份有限公司 | Traditional Chinese medicinal gel for treating bedsore and preparation method of traditional Chinese medicinal gel |
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