CN105288401A - Pharmaceutical composition for treating bedsores and preparing method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition for treating bedsores and a preparing method thereof. The pharmaceutical composition is prepared from, by weight, 20-30 parts of radix ophiopogonis, 15-25 parts of folium eucalypti, 10-20 parts of centella asiatica, 15-20 parts of ligusticum wallichii, 10-15 parts of angelica sinensis, 10-18 parts of lycium barbarum, 10-18 parts of galangal, 5-10 parts of ampelopsis japonica, 5-15 parts of sanguisorba officinalis, 10-15 parts of radix rehmanniae recens and 5-15 parts of liquorice. The formula of the traditional Chinese medicine is reasonable, synergistic effect is good, the traditional Chinese medicine can clear heat for detoxication, activate blood circulation to remove stasis, clear away decay and toxicity, and promote tissue and skin regeneration, blood vessels and meridians are unblocked while decay and toxicity are cleared away, autophage of skin can be accelerated, toxin and bacteria can be discharged out of open sores quickly, the immunity of the organism is improved, resistance to bacteria and fungi is improved, and reinfection after wound healing is avoided.

Description

A kind of pharmaceutical composition for the treatment of decubital ulcer and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of decubital ulcer and preparation method thereof.

Background technology

Decubital ulcer has another name called pressure ulcer, pressure ulcer, is the normal phase pressurized of local organization, continuous ischemia, anoxia, malnutrition and cause local organization fester, downright bad, be one of clinical common complication.The traditional Chinese medical science is called " bed-sore ", is because prolonged illness QI and blood is lost greatly, long-term bed, local compression so that vim and vigour running not normal, meridians block, and are difficult caused by flourish skin, and as given treatment to not in time, meat rotten bone dew concurrent infection, causes septicemia time serious, cause death.

Compared with Chinese patent medicine, many application disinfectant or antibiotic when traditional doctor trained in Western medicine is changed dressings, although effectively can control antibacterial, but also inevitably inhibit the health regeneration of wound surface cell, thus causing wound healing slowly, protracted inflammation is not healed, and affects the live and work of patient.

The main principle for the treatment of by Chinese herbs decubital ulcer is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing the necrotic tissue and promoting granulation, promotes that slough is discharged, and accelerates granulation tissue growth, necrotic tissue cleaning is external, improve the microcirculation of wound surface surrounding tissue, increase regional flow, can promote that remaining epithelial cell tissues grows, putrefaction-removing granulation-promoting simultaneously, activate body endogenous debridement process, show as painless debridement, normal tissue has no side effect, and fills wound sinus tract and lacuna, prevents wound from subsiding, ease the pain, absorb wound exudate.

Chinese patent application 201510239732.0 discloses a kind of Chinese medicine ointment being used for the treatment of decubital ulcer, and this ointment is obtained by following raw material: Cortex Phellodendri, Sanguis Draxonis, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, the Radix Angelicae Dahuricae, Rhizoma Atractylodis, Radix Angelicae Sinensis, Radix Codonopsis, Radix Ampelopsis, Olibanum (processed), Myrrha, Rhizoma Chuanxiong, Radix Trichosanthis, Cornu Cervi Degelatinatum, the Radix Paeoniae Alba, stir-fry Squama Manis etc.This ointment has certain curative effect in treatment decubital ulcer, but this Drug therapy decubital ulcer is long for the course for the treatment of, and Chinese prescription is complicated, and treatment cost is high.

Summary of the invention

There is to solve in prior art the medicine for the treatment of decubital ulcer the shortcoming that healing is slow, treatment time is long and treatment cost is high, the object of the present invention is to provide a kind of pharmaceutical composition for the treatment of decubital ulcer, to solve the problem.Meanwhile, the present invention also provides the preparation technology of this pharmaceutical composition.

Pharmaceutical composition of the present invention comprises the raw materials of following parts by weight: Radix Ophiopogonis 20-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-25, Herba Centellae 10-20, Rhizoma Chuanxiong 15-20, Radix Angelicae Sinensis 10-15, Fructus Lycii 10-18, Rhizoma Alpiniae Officinarum 10-18, Radix Ampelopsis 5-10, Radix Sanguisorbae 5-15, Radix Rehmanniae 10-15 and Radix Glycyrrhizae 5-15.

Further, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 20, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15, Herba Centellae 10, Rhizoma Chuanxiong 15, Radix Angelicae Sinensis 10, Fructus Lycii 10, Rhizoma Alpiniae Officinarum 10, Radix Ampelopsis 5, Radix Sanguisorbae 5, Radix Rehmanniae 10 and Radix Glycyrrhizae 5.

Further, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 25, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20, Herba Centellae 15, Rhizoma Chuanxiong 18, Radix Angelicae Sinensis 12, Fructus Lycii 15, Rhizoma Alpiniae Officinarum 12, Radix Ampelopsis 8, Radix Sanguisorbae 10, Radix Rehmanniae 12 and Radix Glycyrrhizae 10.

Further, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25, Herba Centellae 20, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Fructus Lycii 18, Rhizoma Alpiniae Officinarum 18, Radix Ampelopsis 10, Radix Sanguisorbae 15, Radix Rehmanniae 15 and Radix Glycyrrhizae 15.

In addition, present invention also offers a kind of preparation method for the treatment of the pharmaceutical composition of decubital ulcer, comprise the following steps:

S1: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;

S2: take Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae and Rhizoma Chuanxiong, mixing, pulverize, the concentration adding medical material gross weight 4-8 times amount is the alcoholic solution of 65-80%, reflux, extract, 2-3 time, each 4-12 hour, filter, filtering residue is for subsequent use, merging filtrate, distilling under reduced pressure removing ethanol, obtains under 55-60 DEG C of condition, be concentrated into the concentrated solution A that relative density is 1.20-1.25;

S3: take Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae, add residue and described filtering residue described Radix Ophiopogonis, pulverize, add the water of above-mentioned medical material gross weight 4-9 times amount, decoct 2-3 time, each 3-6 hour, filter, merging filtrate, is concentrated into the concentrated solution B that relative density is 1.20-1.25 under 55-60 DEG C of condition;

S4: described Radix Ophiopogonis extract, described concentrated solution A and described concentrated solution B are mixed, being evaporated to relative density under 55-60 DEG C of condition is the thick paste of 1.20-1.35, and drying under reduced pressure, obtains pharmaceutical composition.

Pharmaceutical composition of the present invention preferably makes powder, ointment or gel, is convenient to patient and uses.

In pharmaceutical composition of the present invention component used source, nature and flavor, return through and effect:

Radix Ophiopogonis: be the tuber of liliaceous plant Radix Ophiopogonis, Hubei Radix Ophiopogonis, short Roripa mountain wheat or Radix Liriopes, dwarf lilyturf etc.; Sweet, micro-hardship, is slightly cold, GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Can immunologic function be improved, have inhibitory action to various bacteria, pituitary adrenal system function can be strengthened, improve organism adaptation ability, have arrhythmia and the peripheral vascular effect of expansion, can hypoxia-bearing capability be improved, have hypoglycemic activity.

Folium eucalypti globueli (Eucalyptus globulus Labill.): this product is the leaf for myrtle Eucalyptus globulus Labill; Bitter in the mouth, warm in nature; Return lung, stomach, spleen, Liver Channel; Dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing, phlegm-eliminiating and qi-regulating, killing parasites for relieving itching.

Herba Centellae: this product is the dry herb of samphire Herba Centellae; Bitter in the mouth, cold in nature; Return liver,spleen,kidney warp; Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.

Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.

Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, warm in nature; Return liver, the heart, spleen channel; Enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

Fructus Lycii: this product is the dry mature fruit of plant of Solanaceae lycium barbarum; Sweet in the mouth, property is put down; Return liver, kidney channel; Nourishing the liver and kidney, replenishing vital essence to improve eyesight.

Rhizoma Alpiniae Officinarum: this product is the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum; Acrid in the mouth, hot in nature; Return spleen, stomach warp; Warming stomach for dispelling cold, help digestion pain relieving.

Radix Ampelopsis: this product is the dried root of vitaceae Radix Ampelopsis; Bitter in the mouth, cold nature; GUIXIN, stomach warp; Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.

Radix Sanguisorbae: this product is the dry root of rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves; Bitter in the mouth, cold nature; Enter liver, large intestine channel; Cooling blood for hemostasis, removing toxic substances sore.

Radix Rehmanniae: the fresh rhizome that this product is scrophulariaceae rehmannia glutinosa plant; Sweet-bitter flavor, cold nature; Enter the heart, liver, kidney channel; Heat clearing away, removing heat from blood, to promote the production of body fluid.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

The prescription analysis of Chinese prescription of the present invention:

Chinese prescription of the present invention is with Radix Ophiopogonis, Folium eucalypti globueli (Eucalyptus globulus Labill.) for monarch drug, dispersing cold for relieving pain, dispelling wind to relieve the exterior syndrome, heat-clearing and toxic substances removing; With Herba Centellae, Rhizoma Chuanxiong and when being classified as ministerial drug, removing toxic substances and promoting subsidence of swelling, granulation promoting, wind-expelling pain-stopping; With Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae for adjuvant drug, enrich blood invigorate blood circulation, the pain relieving that helps digestion, removing toxic substances sore; With Radix Glycyrrhizae for making medicine, making all medicine coordinated, complementing each other, jointly reach the effects such as removing toxic substances and promoting subsidence of swelling, blood circulation promoting and blood stasis dispelling, granulation promoting skin, have very significant therapeutic effect to decubital ulcer.

Compared with prior art, pharmaceutical composition of the present invention has effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, the rotten poison of removing and granulation promoting skin in treatment decubital ulcer, dredging blood vessel meridians while the rotten poison of removing, the own metabolism of skin can be accelerated, toxin and antibacterial is enable to discharge the open sore part fast, further enhancing human body immunity power, strengthens the resistance to antibacterial, fungus, infects once again after avoiding wound healing simultaneously.And preparation method provided by the invention is simple and easy to do, applied widely, toxic and side effects is little, be easy to apply.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

Embodiment 1

The embodiment of the present invention 1 pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 20, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15, Herba Centellae 10, Rhizoma Chuanxiong 15, Radix Angelicae Sinensis 10, Fructus Lycii 10, Rhizoma Alpiniae Officinarum 10, Radix Ampelopsis 5, Radix Sanguisorbae 5, Radix Rehmanniae 10 and Radix Glycyrrhizae 5.

Preparation method is as follows: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 45% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 18L/h, and extracting pressure is 16MPa, extraction temperature is 50 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis; Take Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae and Rhizoma Chuanxiong, mixing, pulverize, the concentration adding medical material gross weight 5 times amount is the alcoholic solution of 75%, reflux, extract, 2 times, each 6 hours, filter, filtering residue is for subsequent use, merging filtrate, distilling under reduced pressure removing ethanol, obtains under 60 DEG C of conditions, be concentrated into the concentrated solution A that relative density is 1.25; Take Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae, add residue and described filtering residue described Radix Ophiopogonis, pulverize, add the water of above-mentioned medical material gross weight 6 times amount, decoct 2 times, each 5 hours, filter, merging filtrate, is concentrated into the concentrated solution B that relative density is 1.25 under 60 DEG C of conditions; Described Radix Ophiopogonis extract, described concentrated solution A and described concentrated solution B are mixed, being evaporated to relative density under 60 DEG C of conditions is the thick paste of 1.30, and drying under reduced pressure, obtains pharmaceutical composition.Add suitable adjuvant, utilize modern general Chinese medicine preparation technology, pharmaceutical composition is made ointment, and amounting to crude drug content is 7.53g crude drug/pipe.

Embodiment 2

The embodiment of the present invention 2 pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 25, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20, Herba Centellae 15, Rhizoma Chuanxiong 18, Radix Angelicae Sinensis 12, Fructus Lycii 15, Rhizoma Alpiniae Officinarum 12, Radix Ampelopsis 8, Radix Sanguisorbae 10, Radix Rehmanniae 12 and Radix Glycyrrhizae 10.

Preparation method is similar to Example 1, makes ointment.

Embodiment 3

The embodiment of the present invention 3 pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25, Herba Centellae 20, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Fructus Lycii 18, Rhizoma Alpiniae Officinarum 18, Radix Ampelopsis 10, Radix Sanguisorbae 15, Radix Rehmanniae 15 and Radix Glycyrrhizae 15.

Preparation method is as similar in embodiment 1, makes powder.

pharmacodynamic experiment

one,medicine composite for curing Cavia porcellus decubital ulcer model test of the present invention

1. test material:

1.1, experimental animal: male guinea pig, body weight (250 ± 25) g, is provided by Nanjing Medical University's animal experimental center.

1.2, test drug: the ointment for the treatment of decubital ulcer prepared by embodiment 1, (the accurate word of traditional Chinese medicines is MAYINGLONG MUSK HEMORRHOID UNGUENTUM: Z42021920).

2. set up animal model: 60 Cavia porcelluss to be anaesthetized, skin degerming, fix with ventricumbent position, cutting near the left side of back spinal column the openning that is being about 3cm, implant through autoclaved 4.0cmx2.5cmx0.05cm stainless-steel sheet, sew up the incision, and bind up a wound, fix with binder.The postoperative single cage of Cavia porcellus is fed, and observes ld.4.0cmx2.5cmx1.0cm Magnet compressing wound surface (5h/d) after 24h, rest 12h circulates 1 time, total pressing time 10h, the formation area of record decubital ulcer and calibration grade.Divide cage separately by animal, feed and management condition consistent.

3. test method: Cavia porcellus decubital ulcer model forms latter 2nd day, Cavia porcellus is divided into 3 groups at random, is respectively normal group, positive controls and embodiment 1 group, each group process is as follows:

Normal group: after cleaning a wound with 0.9% sodium chloride, does not do other process;

Positive controls: after cleaning a wound with 0.9% sodium chloride, MAYINGLONG MUSK HEMORRHOID UNGUENTUM is applied to wound;

Embodiment 1 group: after cleaning a wound with 0.9% sodium chloride, the ointment for the treatment of decubital ulcer embodiment 1 prepared is applied to wound;

Aforesaid operations smears 1 time every day, and medication judged effect after 14 days.

4. observation index:

According to decubital ulcer staging scale, cure as wound disappears, epidermis heals; Transfer well wound contraction 80% to, granulation is fresh, grows, edema extinction, and sepage is few; Invalid is wound contraction 50%, granulation undergrowth or have purulence sepage.

5. result of the test

Note: compare with normal group, ^{△ △}p < 0.01.

As shown in Table 1, the ointment of the treatment decubital ulcer using the embodiment of the present invention 1 to prepare heals substantially at about 10 days wounds, and cure rate reaches 70%, and inefficiency is 0, proves that bedsore ointment prepared by the present invention has significant therapeutic effect to decubital ulcer.

Two, the clinical trial of pharmaceutical composition of the present invention

1. clinical study

Choose the clinical volunteers patient that 100 examples suffer from decubital ulcer, wherein man 50 example, female 50 example, age 48-80 year, patient is skin ulcer face diameter 1 ~ 30cm before the treatment, ulcerative stage 68 example, deep ulcer phase 32 example, be divided into 2 groups at random, be respectively treatment group and matched group, often organize 50 people.Two groups of Genders, age, severity extent and clinical manifestations, through statistical procedures no significant difference, have comparability.

2. trial drug and test method

Treatment group: the ointment smearing treatment decubital ulcer prepared by the embodiment of the present invention 1, changes dressings 1 every day, each 0.52-1.04g, Continuous Observation 14 days.

Matched group: wound surface surrounding skin 75% alcohol disinfecting, wound surface 0.1% bromo geramine cleans, and wipes out slough as far as possible, then applies with Oleum Radix Arnebiae (Oleum Radix Lithospermi) gauze, and cover wrapping with sterile gauze, other are identical with observation group.

3. criterion of therapeutical effect

" the Chinese medical disease Standardization of diagnosis and curative effect " implemented with reference to the State Administration of Traditional Chinese Medicines is also drafted in conjunction with the concrete condition of this research.

Recovery from illness: wound healing, without inflammatory exudation, skin ulcer reduction of area is little, has new granulation tissue to generate and epithelial tissue covering;

Effective: traumatic infection controls, and the little >80% of skin ulcer reduction of area, have granulation tissue to generate, but wound does not heal completely;

Invalid: before and after treatment, wound contrast is not improved, and have no granulation growth, wound surface reduces <40%.

4. result of the test

5. conclusion (of pressure testing)

Result of the test shows, and the ointment for the treatment of decubital ulcer prepared by the present invention has significant effect in treatment decubital ulcer, and cure rate reaches 78%, and total effective rate reaches 94%, is obviously better than the effect of matched group.Clinical test results shows, the ointment for the treatment of decubital ulcer prepared by the present invention has significant technical advantage in treatment decubital ulcer, can apply as clinical treatment decubital ulcer medicine.

Claims (6)

1. treat the pharmaceutical composition of decubital ulcer for one kind, it is characterized in that, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 20-30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15-25, Herba Centellae 10-20, Rhizoma Chuanxiong 15-20, Radix Angelicae Sinensis 10-15, Fructus Lycii 10-18, Rhizoma Alpiniae Officinarum 10-18, Radix Ampelopsis 5-10, Radix Sanguisorbae 5-15, Radix Rehmanniae 10-15 and Radix Glycyrrhizae 5-15.

2. the pharmaceutical composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 20, Folium eucalypti globueli (Eucalyptus globulus Labill.) 15, Herba Centellae 10, Rhizoma Chuanxiong 15, Radix Angelicae Sinensis 10, Fructus Lycii 10, Rhizoma Alpiniae Officinarum 10, Radix Ampelopsis 5, Radix Sanguisorbae 5, Radix Rehmanniae 10 and Radix Glycyrrhizae 5.

3. the pharmaceutical composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 25, Folium eucalypti globueli (Eucalyptus globulus Labill.) 20, Herba Centellae 15, Rhizoma Chuanxiong 18, Radix Angelicae Sinensis 12, Fructus Lycii 15, Rhizoma Alpiniae Officinarum 12, Radix Ampelopsis 8, Radix Sanguisorbae 10, Radix Rehmanniae 12 and Radix Glycyrrhizae 10.

4. the pharmaceutical composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described pharmaceutical composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 30, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25, Herba Centellae 20, Rhizoma Chuanxiong 20, Radix Angelicae Sinensis 15, Fructus Lycii 18, Rhizoma Alpiniae Officinarum 18, Radix Ampelopsis 10, Radix Sanguisorbae 15, Radix Rehmanniae 15 and Radix Glycyrrhizae 15.

5. the pharmaceutical composition for the treatment of decubital ulcer as claimed in claim 1, it is characterized in that, described pharmaceutical composition is made into powder, ointment or gel.

6. the preparation method of the pharmaceutical composition of the treatment decubital ulcer as described in as arbitrary in claim 1-4, it is characterized in that, the preparation method of described pharmaceutical composition comprises following step:

S1: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;

S2: take Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Centellae and Rhizoma Chuanxiong, mixing, pulverize, the concentration adding medical material gross weight 4-8 times amount is the alcoholic solution of 65-80%, reflux, extract, 2-3 time, each 4-12 hour, filter, filtering residue is for subsequent use, merging filtrate, distilling under reduced pressure removing ethanol, obtains under 55-60 DEG C of condition, be concentrated into the concentrated solution A that relative density is 1.20-1.25;

S3: take Radix Angelicae Sinensis, Fructus Lycii, Rhizoma Alpiniae Officinarum, Radix Ampelopsis, Radix Sanguisorbae, Radix Rehmanniae and Radix Glycyrrhizae, add residue and described filtering residue described Radix Ophiopogonis, pulverize, add the water of above-mentioned medical material gross weight 4-9 times amount, decoct 2-3 time, each 3-6 hour, filter, merging filtrate, is concentrated into the concentrated solution B that relative density is 1.20-1.25 under 55-60 DEG C of condition;

S4: described Radix Ophiopogonis extract, described concentrated solution A and described concentrated solution B are mixed, being evaporated to relative density under 55-60 DEG C of condition is the thick paste of 1.20-1.35, and drying under reduced pressure, obtains pharmaceutical composition.