CN105343847A - Traditional Chinese medicine composition for treating eczema containing folium artemisiae argyi and preparing method thereof - Google Patents
Traditional Chinese medicine composition for treating eczema containing folium artemisiae argyi and preparing method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating eczema containing folium artemisiae argyi and a preparing method thereof. The traditional Chinese medicine composition is mainly prepared from, by weight, 25-34 parts of folium artemisiae argyi, 23-32 parts of pepper, 18-23 parts of schizonepeta, 19-26 parts of cortex dictamni, 17-25 parts of periostracum cicada, 16-24 parts of coptidis rhizome, 18-25 parts of lithospermum, 13-19 parts of astragalus membranaceus, 12-19 parts of cinnamon, 15-20 parts of albizia flower, 14-21 parts of tuber fleeceflower stems, 11-17 parts of radix paeoniae alba, 12-18 parts of fresh ginger and 6-15 parts of liquorice. The traditional Chinese medicine composition has the advantages of being capable of becoming effective quickly in terms of itching relieving, good in treatment effect and not irritant to skin when used for treating eczema. Furthermore, the preparation technology is simple, the efficacy of a preparation of the traditional Chinese medicine composition is stable, the medication compliance of patients is high, the application range is wide, and application and popularization are facilitated.
Description
Technical field
The invention belongs to the field of Chinese medicines, particularly relate to Chinese medicine composition of a kind for the treatment of eczema containing Folium Artemisiae Argyi and preparation method thereof.
Background technology
Eczema is a kind of common allergic inflammation dermatoses, and its feature is pleomorphism erythra, oozes out tendency, symmetrical, is easy to recurrence and chronicity.More eczematosis, because of more complicated, thought anaphylactic disease at present, is belonged to type Ⅳ allergy.Anaphylactogen can from the external world, also can from internal body.Enviromental allergen as the toxin of chemical drugs, cosmetics, dyestuff, some animal, foreign preteins and some pollen, the dust etc. such as egg, fish, shrimp, milk.Inner anaphylactogen is as internal lesions, and intestinal parasitic disease, some metabolism, endocrine or digestive tract function imbalance and human body itself are under some is organized in the impact of some factor, and its composition changes and forms autoantibody etc.
The traditional Chinese medical science thinks that this disease is strong mainly due to disease just taste mistake, endogenous dampness, strongly fragrant heat-transformation of a specified duration, retention of damp-heat in the interior, and then rash color is scarlet for outer more skin, contamination flow liquid, and disease is recurrent exerbation for a long time, and cloudy blood is consumed; Qi-blood disharmony, the raw wind of dryness-transformation, failure of skin and muscle to be nourished, coarse plumpness, touching difficulty more.In a word, this disease belongs to damp and hot, and heat in blood, dampness, caused by blood is dry.Clinical should according to the body constitution of patient, arteries and veins card, Selection drug, can not adhere rigidly to into side.
Western medical treatment is based on antihistamine drug for oral administration, medicine for external use is mainly selected the soaks such as solution, lotion, paste or ointment according to different stadium performance or is coated with outward, when there is secondary infection, can consider to use antibiotic therapy, but there is larger toxic and side effects to skin in some Western medicine, the simultaneously treatment such as antibiotic, hormone not only directly can affect the health of patient, and long period or short-term heavy dose use, and addiction also can cause drug dependence dermatitis.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant., has another name called moxibustion grass, Artemisia argyi Levl. et Van. var. argyi cv. Qiai, Radix Artemisia ordosicae and Ai Peng etc., its bitter in the mouth, pungent, warm in nature; Return liver,spleen,kidney warp; Having blood of regulating the flow of vital energy, warming the meridian for stopping bleeding, the effects such as dispersing cold for relieving pain, is a kind of gynecological good medicine, and for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile.Pharmacological research represents, Folium Artemisiae Argyi all has antibacterial action to various bacteria such as staphylococcus aureus, escherichia coli, bacillus subtilis in vitro, and Oleum Folium Artemisiae Argyi has antagonism to the anaphylactic shock guinea-pigs that ovalbumin causes simultaneously, can reduce mortality rate.Chinese patent application 201210287998.9 discloses a kind of application compress for the treatment of eczema, this medicine is by being immersed in the rice vinegar through boiling cooling respectively by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug, inoculate acetobacter, when different fermentations after indirect fermentation, then its fermentation liquid is blent make.This medicine has certain curative effect in treatment eczema, but this process for preparing medicine is complicated, and treatment is long for the course for the treatment of.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi, and this Chinese medicine composition can Quick itch stopping, and pointed strong, advantage that good effect, relapse rate are low, has good long-term effect.
In addition, the present invention also provides the preparation technology of this Chinese medicine composition, on the basis ensureing curative effect, Chinese medicine is made universality is strong, be easy to carry about with one the finished product preparation used.
The Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi of the present invention forms primarily of the raw materials of following parts by weight: Folium Artemisiae Argyi 25-34 part, Pericarpium Zanthoxyli 23-32 part, Herba Schizonepetae 18-23 part, Cortex Dictamni 19-26 part, Periostracum Cicadae 17-25 part, Rhizoma Coptidis 16-24 part, Radix Arnebiae (Radix Lithospermi) 18-25 part, Radix Astragali 13-19 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-19 part, Flos Albiziae 15-20 part, Caulis Polygoni Multiflori 14-21 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-15 part.
Preferably, the Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi of the present invention forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 25 parts, 23 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 19 parts, Periostracum Cicadae 17 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, the Radix Astragali 13 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts, Rhizoma Zingiberis Recens and 6 parts, Radix Glycyrrhizae.
Preferably, the Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi of the present invention forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 34 parts, 32 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 23 parts, Cortex Dictamni 26 parts, Periostracum Cicadae 25 parts, Rhizoma Coptidis 24 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, the Radix Astragali 19 parts, 19 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 20 parts, Caulis Polygoni Multiflori 21 parts, the Radix Paeoniae Alba 17 parts, Rhizoma Zingiberis Recens 12-18 part and 15 parts, Radix Glycyrrhizae.
Preferably, the Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi of the present invention forms primarily of the raw materials of following parts by weight: Folium Artemisiae Argyi 29 parts, 26 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 20 parts, Cortex Dictamni 23 parts, Periostracum Cicadae 21 parts, Rhizoma Coptidis 20 parts, Radix Arnebiae (Radix Lithospermi) 21 parts, the Radix Astragali 17 parts, 16 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 18 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 14 parts, 16 parts, Rhizoma Zingiberis Recens and 9 parts, Radix Glycyrrhizae.
The preparation method of Chinese medicine composition of the present invention comprises following steps:
S1: get Folium Artemisiae Argyi, Pericarpium Zanthoxyli, the Radix Astragali and Rhizoma Zingiberis Recens, pulverizes, adds the ethanol of the concentration 65-80% of medical material total amount 7-12 times weight, reflux, extract, 2-3 time, each 2-5 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the Chinese medical concrete of 1.20-1.30, drying under reduced pressure, pulverizes, cross 100-200 mesh sieve, obtain uniform fine powder;
S2: get Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, pulverize, add the water soaking 12-24 hour of medical material gross weight 8-10 times amount, decocts 1-3 hour; Filter, filtering residue adds the water of medical material gross weight 6-8 times amount, decocts 1-2 hour; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20-1.30 that filtrate is concentrated into relative density at 50 DEG C-60 DEG C, drying under reduced pressure, crosses 100-200 mesh sieve, obtains uniform fine powder;
S3: get Herba Schizonepetae, Periostracum Cicadae and Cortex cinnamomi japonici (Ramulus Cinnamomi), grind into powder, crosses 100-200 mesh sieve, and the fine powder obtained with S1 and S2 fully mixes, and obtains Chinese medicine composition of the present invention.
Utilize modern general Chinese medicine preparation technology, Chinese medicine composition of the present invention can be made into the finished product preparation of clinical needs, as dosage forms such as paste, gel, ointment, ointment or liniments.
Source, the nature and flavor of Chinese medicine composition of the present invention Chinese crude drug used, return through and effect:
Folium Artemisiae Argyi: this product is the dried leaves of feverfew Chinese mugwort; Acrid in the mouth, hardship, warm in nature; Return spleen, liver, kidney channel; To regulate the flow of vital energy blood, by cold-damp, dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Pericarpium Zanthoxyli: this product is dry mature skin (Pericarpium Zanthoxyli) and the seed (Semen zanthoxyli) of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)); Acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; Warming spleen and stomach for dispelling cold, removing damp and stopping pain, killing parasites for relieving itching.。
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae; Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.
Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany; Bitter in the mouth, cold in nature; Return spleen, stomach, urinary bladder channel; Heat clearing and damp drying, dispelling wind for relieving itching, removing toxic substances.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr.; Sweet in the mouth, cold in nature; Return lung, Liver Channel; Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.
Rhizoma Coptidis: this product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall; Bitter in the mouth, cold in nature; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
Radix Arnebiae (Radix Lithospermi): this product is the dry root of comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi) or arnebia guttata Bunge; Sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel; Removing heat from blood, invigorates blood circulation, removing toxic substances rash.
The Radix Astragali: this product is the root of leguminous plant Radix Hedysari multijugi; Sweet in the mouth, warm in nature; GUIXIN, lung, spleen, kidney channel; Invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.
Cortex cinnamomi japonici (Ramulus Cinnamomi): this product is the bark in canella Cinnamomum japonica, cloudy perfume, cinnamomum chingii Metcalf or osmanthus, river etc.; Acrid in the mouth, sweet, warm in nature; Return spleen, stomach, liver, kidney channel; Warming the spleen stomach, warm Liver and kidney, cold-dispelling pain-relieving, dissipating blood stasis for subsidence of swelling.
Flos Albiziae: this product is the dry inflorescence of leguminous plant Herba Albiziae; Sweet in the mouth, property is put down; GUIXIN, Liver Channel; Shu Yu, regulates the flow of vital energy, and calms the nerves, active.
Caulis Polygoni Multiflori: be rattan or the leaf bine stem of polygonum multiflorum thunb; Sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel;
Tranquilizing by nourishing the heart, dispels the wind, dredging collateral.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Rhizoma Zingiberis Recens: this product is the fresh rhizome of zingiber; Acrid in the mouth, slightly warm in nature; Return lung, spleen, stomach warp; Induce sweat cold expelling.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese medicine composition of the present invention is with Folium Artemisiae Argyi, Herba Schizonepetae, Pericarpium Zanthoxyli for monarch drug, warming middle-JIAO to relieve pain, detoxifying and relieving itching; With Cortex Dictamni, Periostracum Cicadae, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi) for ministerial drug, removing toxic substances rash, heat clearing and damp drying, eliminating fire and detoxication; With Caulis Polygoni Multiflori, the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens for adjuvant drug, tranquilizing by nourishing the heart, expelling pus and toxin by strengthening QI; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, makes all medicines arrange in pairs or groups, jointly reaches sterilizing and itch-relieving, and removing toxic substances rash, expelling pus and toxin by strengthening QI, effect of promoting tissue regeneration and ulcer healing, has significant therapeutic effect to eczema.
Through clinical trial checking, Chinese medicine composition of the present invention has following advantage compared with existing medicine:
1) the present invention significantly can improve the symptom of eczema, rapid-action, treatment short treating period, and can suppress secondary infection.
2) Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and toxic and side effects is little, to no skin irritation.
3) Chinese medicine composition synergism of the present invention is strong, and using dosage is little, can not produce drug dependence simultaneously.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
eXAMPLE l
The embodiment of the present invention 1 Chinese medicine composition forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 25 parts, 23 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 19 parts, Periostracum Cicadae 17 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, the Radix Astragali 13 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts, Rhizoma Zingiberis Recens, 6 parts, Radix Glycyrrhizae.
Preparation method:
S1: get Folium Artemisiae Argyi, Pericarpium Zanthoxyli, the Radix Astragali and Rhizoma Zingiberis Recens, pulverizes, adds the ethanol of the concentration 70% of medical material total amount 9 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the Chinese medical concrete of 1.20, drying under reduced pressure, pulverizes, cross 100 mesh sieves, obtain uniform fine powder;
S2: get Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, pulverize, and adds the water soaking 12 hours of medical material gross weight 8 times amount, decoct 2 hours; Filter, filtering residue adds the water of medical material gross weight 6 times amount, decocts 1.5 hours; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 100 mesh sieves, obtains uniform fine powder;
S3: get Herba Schizonepetae, Periostracum Cicadae and Cortex cinnamomi japonici (Ramulus Cinnamomi), grind into powder, crosses 100 mesh sieves, and the fine powder obtained with S1 and S2 fully mixes, and obtains Chinese medicine composition of the present invention;
S4: carbomer and emulsifying agent Polysorbate are added enough water soakings 30 hours, makes carbomer moisten completely and rises, then adds sodium citrate and glacial acetic acid regulates its pH value to be 7.5, mix homogeneously, obtained gel-type vehicle;
S5: the Chinese medicine composition of the present invention that S3 is obtained is soluble in water, joins in gel-type vehicle successively, stir glycerol and butanediol, Chinese medicine composition solution of the present invention, obtain Chinese medicine composition gelata of the present invention.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 34 parts, 32 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 23 parts, Cortex Dictamni 26 parts, Periostracum Cicadae 25 parts, Rhizoma Coptidis 24 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, the Radix Astragali 19 parts, 19 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 20 parts, Caulis Polygoni Multiflori 21 parts, the Radix Paeoniae Alba 17 parts, 18 parts, Rhizoma Zingiberis Recens, 15 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 29 parts, 26 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 20 parts, Cortex Dictamni 23 parts, Periostracum Cicadae 21 parts, Rhizoma Coptidis 20 parts, Radix Arnebiae (Radix Lithospermi) 21 parts, the Radix Astragali 17 parts, 16 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 18 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 14 parts, 16 parts, Rhizoma Zingiberis Recens, 9 parts, Radix Glycyrrhizae.
Preparation method:
S1: get Folium Artemisiae Argyi, Pericarpium Zanthoxyli, the Radix Astragali and Rhizoma Zingiberis Recens, pulverizes, adds the ethanol of the concentration 75% of medical material total amount 10 times of weight, reflux, extract, 2 times, each 2 hours, filter, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 60 DEG C of relative densities be the Chinese medical concrete of 1.25, drying under reduced pressure, pulverizes, cross 100 mesh sieves, obtain uniform fine powder;
S2: get Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, pulverize, and adds the water soaking 24 hours of medical material gross weight 10 times amount, decoct 3 hours; Filter, filtering residue adds the water of medical material gross weight 8 times amount, decocts 2 hours; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20 that filtrate is concentrated into relative density at 60 DEG C, drying under reduced pressure, crosses 100 mesh sieves, obtains uniform fine powder;
S3: get Herba Schizonepetae, Periostracum Cicadae and Cortex cinnamomi japonici (Ramulus Cinnamomi), grind into powder, crosses 100 mesh sieves, and the fine powder obtained with S1 and S2 fully mixes, and obtains Chinese medicine composition of the present invention.
S4: get sodium carboxymethyl cellulose and be placed in mortar, adds glycerol and grinds well, and then grinds while add the alcoholic solution of ethyl hydroxybenzoate, grinds well after swelling, and the Chinese medicine composition gradation that S3 is obtained adds, and grinds well, obtains the ointment of Chinese medicine composition of the present invention.
embodiment 4
The embodiment of the present invention 4 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 30 parts, 25 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 17 parts, Cortex Dictamni 20 parts, Periostracum Cicadae 20 parts, Rhizoma Coptidis 20 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, the Radix Astragali 15 parts, 15 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 20 parts, the Radix Paeoniae Alba 15 parts, 14 parts, Rhizoma Zingiberis Recens, 12 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 3.
chinese medicine composition pharmacodynamic study of the present invention:
test one: Chinese medicine composition of the present invention is to the development test of ear eczema mice.
Experimental animal: provide cleaning grade kunming mice 50 by certain Bioisystech Co., Ltd, body weight 22g ± 4g, male and female half and half.50 mices are divided into 5 groups at random, often organize 10.
Ear eczema Establishment of mouse model: first day is in two-sided dinitrochlorobenzene (DNCB) the solution sensitization of smearing 40 μ L5% of mice ears, within 4th day, smear the DNCB solution of 40 μ L1%, once smeared once every four days afterwards, totally 5 times, set up ear eczema mouse model.
Dosage regimen:
A group: get the Chinese medicine composition gelata of the present invention that the embodiment of the present invention 1 is obtained; Smear DNCB excites rear 24h, 48h, 72h to be coated with trial drug outward inside mice ears at every turn, and 1g/ is each, 2 times/day.
B group: get the Chinese medicine composition gelata of the present invention that the embodiment of the present invention 2 is obtained; Dosage regimen is with A group.
C group: get the Chinese medicine composition ointment of the present invention that the embodiment of the present invention 3 is obtained; Dosage regimen is with A group.
Positive controls: get Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the accurate word H44024298 of traditional Chinese medicines), dosage regimen is with A group.
Model control group: the gel getting not drug containing in the embodiment of the present invention 1, dosage regimen is with A group.
Carry out the score of skin lesion degree by following standard: the obvious redness of ears thickens and oozes out, or obviously keratinization incrustation person remembers 3 points; Mild redness, oozes out not obvious, or moderate keratinization person is designated as 2 points; Red and swollen and ooze out all not obvious person, or slight keratinization person is designated as 1 point; Normal skin is 0 point.
Use spiral micrometer to measure ear swelling thickness respectively simultaneously.
Table 1 Ge Zu ear skin lesion situation compares
Note: compare with model control group,
* p0.05;
* p0.01.
Drug test group is compared with model control group, and mouse ear skin lesion integration and ear swelling thickness all have significant difference.Test data shows, drug test group mice is compared with model control group mice, and ear's skin lesion is clearly better, and ear swelling degree obviously reduces, drug test group C group of the present invention simultaneously, the i.e. Chinese medicine composition of the present invention of the embodiment of the present invention 3 preparation and the therapeutic equivalence of positive controls.Result of the test shows, traditional Chinese medicine composition for treating of the present invention and prevention eczema successful, can be used for clinical expansion.
test two: the clinical trial of Chinese medicine composition of the present invention.
One, diagnostic criteria
Draft with reference to the content of " diagnosis basis of eczema " in " Chinese medical disease Standardization of diagnosis and curative effect ".Diagnostic criteria is:
1, acute eczema
1) skin lesion is pleomorphism, as flushing, pimple, vesicle, erosion, ooze out, crust, desquamation, constant kind form exists simultaneously.
2) onset is anxious, conscious scorching hot, violent pruritus.
3) skin lesion is often symmetrical, common with places such as head, face, distal limbs, scrotum.Can general whole body.
4) subacute or chronic eczema can be developed into, time light time heavy, repeatedly do not heal.
2, subacute eczema: skin lesion oozes out less, based on pimple, papulovesicle, incrustation, squama.Have slight rotten to the corn face, color is more dark red.Also visible mild infiltration, violent pruritus.
3, chronic eczema: many limits office is in a certain position, and boundary is clear, have significantly plump infiltration, rough surface, or become in lichen sample, the brown red or brown of color, often with papulovesicle, crust, scratch.Be inclined to moistening change, normal recurrent exerbation, time light time heavy, have paroxysmal pruritus.
Two, clinical trial protocol
1. subjects basic document
The present invention collect clinical eczema volunteer 90 example, man 48 example, female 42 example, age 16-45 year, all experimenters are divided at random 2 groups, often organize 45,2 group case in sex, age, the course of disease etc. through statistical analysis, there is comparability.
2. trial drug and test method
Treatment group: ointment prepared by the embodiment of the present invention 3, often prop up ointment and contain medicine 12.5g, spread upon eczema place, every day, secondary, smeared 10 days continuously.
Positive controls: smear Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the accurate word H44024298 of traditional Chinese medicines), twice daily, smear 10 days continuously.
3. criterion of therapeutical effect
Effective: eczema erythema obviously reduces, attack times reduces.
Invalid: compare with before treatment, symptom does not disappear or increases the weight of on the contrary.
Recurrence: cure latter 3 months and run into warm and still show effect.
4. therapeutic outcome, as shown in table 2
Table 2 therapeutic effect
| Number of cases | Effectively (example) | Invalid (example) | Recurrence (example) | Total effective rate | |
| Treatment group | 45 | 42 | 3 | 1 | 93.33% |
| Positive controls | 45 | 40 | 5 | 5 | 88.89% |
Result of the test shows, the effect for the treatment of group traditional Chinese medicine composition for treating eczema of the present invention is better than positive control drug Compound Dexamethasone Cream.Treatment group is compared with positive controls, the total effective rate for the treatment of group is 93.33% higher than the total effective rate 88.89% of positive controls group, and the recurrence number of cases for the treatment of group is significantly lower than the recurrence number of cases of positive controls, clinical observation, treatment group patient has no any untoward reaction at therapeutic process.Traditional Chinese medicine composition for treating eczema of the present invention is rapid-action, and safety is high, and relapse rate is low, and clinical generalization value is high.
Claims (6)
1. a Chinese medicine composition for the treatment eczema containing Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following weight portion:
Folium Artemisiae Argyi 25-34 part, Pericarpium Zanthoxyli 23-32 part, Herba Schizonepetae 18-23 part, Cortex Dictamni 19-26 part, Periostracum Cicadae 17-25 part, Rhizoma Coptidis 16-24 part, Radix Arnebiae (Radix Lithospermi) 18-25 part, Radix Astragali 13-19 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 12-19 part, Flos Albiziae 15-20 part, Caulis Polygoni Multiflori 14-21 part, Radix Paeoniae Alba 11-17 part, Rhizoma Zingiberis Recens 12-18 part and Radix Glycyrrhizae 6-15 part.
2. the Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 25 parts, 23 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 18 parts, Cortex Dictamni 19 parts, Periostracum Cicadae 17 parts, Rhizoma Coptidis 16 parts, Radix Arnebiae (Radix Lithospermi) 18 parts, the Radix Astragali 13 parts, 12 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 15 parts, Caulis Polygoni Multiflori 14 parts, the Radix Paeoniae Alba 11 parts, 12 parts, Rhizoma Zingiberis Recens and 6 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 34 parts, 32 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 23 parts, Cortex Dictamni 26 parts, Periostracum Cicadae 25 parts, Rhizoma Coptidis 24 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, the Radix Astragali 19 parts, 19 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 20 parts, Caulis Polygoni Multiflori 21 parts, the Radix Paeoniae Alba 17 parts, Rhizoma Zingiberis Recens 12-18 part and 15 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition of the treatment eczema containing Folium Artemisiae Argyi according to claim 1, it is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following parts by weight:
Folium Artemisiae Argyi 29 parts, 26 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 20 parts, Cortex Dictamni 23 parts, Periostracum Cicadae 21 parts, Rhizoma Coptidis 20 parts, Radix Arnebiae (Radix Lithospermi) 21 parts, the Radix Astragali 17 parts, 16 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 18 parts, Caulis Polygoni Multiflori 18 parts, the Radix Paeoniae Alba 14 parts, 16 parts, Rhizoma Zingiberis Recens and 9 parts, Radix Glycyrrhizae.
5., according to the Chinese medicine composition of the arbitrary described treatment eczema containing Folium Artemisiae Argyi of claim 1-4, it is characterized in that, described Chinese medicine composition is made into paste, gel, ointment, ointment or liniment.
6., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment eczema containing Folium Artemisiae Argyi of claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following steps:
S1: get Folium Artemisiae Argyi, Pericarpium Zanthoxyli, the Radix Astragali and Rhizoma Zingiberis Recens, pulverizes, adds the ethanol of the concentration 65-80% of medical material total amount 7-12 times weight, reflux, extract, 2-3 time, each 2-5 hour, filters, merging filtrate, distilling under reduced pressure removing ethanol, and to be concentrated into 55 DEG C of-60 DEG C of relative densities be the Chinese medical concrete of 1.20-1.30, drying under reduced pressure, pulverizes, cross 100-200 mesh sieve, obtain uniform fine powder;
S2: get Cortex Dictamni, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), Flos Albiziae, Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, pulverize, add the water soaking 12-24 hour of medical material gross weight 8-10 times amount, decocts 1-3 hour; Filter, filtering residue adds the water of medical material gross weight 6-8 times amount, decocts 1-2 hour; Filter, merge twice filtrate, it is the Chinese medical concrete of 1.20-1.30 that filtrate is concentrated into relative density at 50 DEG C-60 DEG C, drying under reduced pressure, crosses 100-200 mesh sieve, obtains uniform fine powder;
S3: get Herba Schizonepetae, Periostracum Cicadae and Cortex cinnamomi japonici (Ramulus Cinnamomi), grind into powder, crosses 100-200 mesh sieve, and the fine powder obtained with S1 and S2 fully mixes, and obtains Chinese medicine composition of the present invention.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770335A (en) * | 2016-03-21 | 2016-07-20 | 张艳娟 | Medicinal preparation for treating chronic eczema and application of medicinal preparation |
| CN106310010A (en) * | 2016-08-25 | 2017-01-11 | 广州暨南生物医药研究开发基地有限公司 | Ointment for treating chronic eczema and preparation method thereof |
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| CN103202903A (en) * | 2013-04-11 | 2013-07-17 | 徐樊 | Traditional Chinese medicine preparation for treating skin eczema |
| CN104721368A (en) * | 2015-04-04 | 2015-06-24 | 淄博夸克医药技术有限公司 | Traditional Chinese medicine for treating eczema |
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| CN103202903A (en) * | 2013-04-11 | 2013-07-17 | 徐樊 | Traditional Chinese medicine preparation for treating skin eczema |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770335A (en) * | 2016-03-21 | 2016-07-20 | 张艳娟 | Medicinal preparation for treating chronic eczema and application of medicinal preparation |
| CN106310010A (en) * | 2016-08-25 | 2017-01-11 | 广州暨南生物医药研究开发基地有限公司 | Ointment for treating chronic eczema and preparation method thereof |
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Application publication date: 20160224 |