CN105213557A - A kind of traditional Chinese medicine composition for treating eczema - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating eczema. The traditional Chinese medicine composition mainly comprises the following preparation raw materials in parts by weight: 26-35 parts of folium artemisiae argyi, 24-33 parts of purslane, 19-24 parts of schizonepeta, 20-27 parts of cortex dictamni, 18-26 parts of periostracum cicada, 17-25 parts of coptis chinensis, 19-26 parts of lithospermum, 14-20 parts of astragalus membranaceus, 13-20 parts of cinnamon, 16-21 parts of albizia flower, 15-22 parts of tuber fleeceflower stem, 12-18 parts of moringa oleifera leaf, 13-19 parts of ginkgo leaf and 10-20 parts of liquorice. The traditional Chinese medicine composition has the advantages of quick itching relieving effect, good treatment effect and no stimulation to skin in the aspect of treating eczema, and the preparation process is simple, convenient and feasible, the preparation has stable drug effect, the patient has high drug compliance, the application range is wide, and the popularization and the application are easy.

Description

A kind of traditional Chinese medicine composition for treating eczema

technical field

The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating eczema.

Background technique

Eczema is a common allergic inflammatory skin disease, characterized by polymorphic rash, exudative tendency, symmetrical distribution, easy to relapse and chronic. The etiology of eczema is more complicated, and it is mostly considered to be an allergic disease at present, belonging to the fourth type of allergy. Allergens can come from the outside world or from inside the body. External allergens such as chemicals, cosmetics, dyes, toxins from certain animals, heterosexual proteins such as eggs, fish, shrimp, and milk, as well as certain pollen and dust. Internal allergens such as internal lesions, intestinal parasitic diseases, some metabolic, endocrine or digestive tract dysfunction, and some tissues of the human body under the influence of certain factors, the composition of which changes to form autoantibodies, etc.

Traditional Chinese medicine believes that the disease is mainly due to spleen and stomach failure at the beginning of the disease, internal dampness, stagnant heat for a long time, damp heat accumulated in the body, and the skin becomes bright red when it is outside, soaked in liquid, and the disease recurs for a long time, and the blood is consumed; Qi and blood Disharmony, dryness and wind, skin loss of nourishment, rough and thick, lingering and difficult to heal. In short, the disease is caused by damp heat, blood heat, damp resistance, and blood dryness. Clinically, prescriptions and medications should be selected according to the patient's constitution and pulse syndrome, and prescriptions should not be rigidly formulated.

Western medicine mainly uses antihistamines for oral administration. For external use, solutions, lotions, pastes, or ointments are mainly used for wet compresses or external application according to the symptoms of different stages of the disease. When there is a secondary infection, antibiotics will be considered for treatment, but Some western medicines have relatively large toxic and side effects on the skin. At the same time, treatments such as antibiotics and hormones will not only directly affect the health of patients, but also lead to addiction and drug-dependent dermatitis if used in large doses for a long time or in a short period of time.

Artemisia argyi is the dried leaf of the plant Artemisia argyi, also known as moxibustion grass, Artemisia argyi, Artemisia argyi and Artemisia argyi, etc. It is bitter, pungent, and warm in nature; it returns to the liver, spleen, and kidney channels; it has the functions of regulating qi and blood, warming the meridian and stopping bleeding. , dispelling cold and relieving pain and other effects, is a good gynecological medicine, used for vomiting blood, epistaxis, metrorrhagia, menorrhagia, fetal leakage, bleeding in the lower abdomen, cold pain in the lower abdomen, irregular menstruation, cold uterine infertility, etc. Pharmacological studies have shown that Artemisia argyi has antibacterial effects on various bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis in vitro. At the same time, Artemisia argyi oil has an antagonistic effect on anaphylactic shock in guinea pigs caused by ovalbumin, which can reduce mortality. Chinese patent application 201210287998.9 discloses a medicine for external application for treating eczema. , and then inoculated with Acetobacter, fermented for different fermentation times, and then blended with the fermented liquid. The medicament has a certain curative effect in treating eczema, but the preparation method of the medicament is complicated and the treatment course is long.

Contents of the invention

The technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition for treating eczema, which can quickly relieve itching, has the advantages of strong pertinence, good curative effect, low recurrence rate, and good long-term effect.

In addition, the present invention also provides the preparation process of the traditional Chinese medicine composition, on the basis of ensuring the curative effect, the traditional Chinese medicine is made into a finished preparation with strong universal applicability and easy to carry and use.

The traditional Chinese medicine composition for treating eczema of the present invention is mainly composed of the following preparation raw materials in parts by weight: 26-35 parts of Artemisia argyi, 24-33 parts of purslane, 19-24 parts of Schizonepeta, 20-27 parts of white fresh skin , 18-26 parts of cicada slough, 17-25 parts of coptis, 19-26 parts of comfrey, 14-20 parts of astragalus, 13-20 parts of cassia bark, 16-21 parts of albizia julibrissin, 15-22 parts of night vine, Moringa leaf 12-18 parts, 13-19 parts of ginkgo biloba and 10-20 parts of licorice.

Preferably, the traditional Chinese medicine composition for treating eczema according to the present invention mainly consists of the following preparation raw materials in parts by weight: 26 parts of Artemisia argyi leaves, 24 parts of purslane, 19 parts of Nepeta chinensis, 20 parts of white fresh skin, 18 parts of cicada slough, 17 parts of coptis, 19 parts of comfrey, 14 parts of astragalus, 13 parts of cinnamon, 16 parts of albizia flower, 15 parts of night vine, 12 parts of Moringa leaf, 13 parts of ginkgo leaf and 10 parts of licorice.

Preferably, the traditional Chinese medicine composition for treating eczema according to the present invention mainly consists of the following preparation raw materials in parts by weight: 35 parts of Artemisia argyi leaves, 33 parts of purslane, 24 parts of Nepeta chinensis, 27 parts of white fresh skin, 26 parts of cicada slough, 25 parts of coptis, 26 parts of comfrey, 20 parts of astragalus, 20 parts of cinnamon, 21 parts of albizia flower, 22 parts of night vine, 18 parts of Moringa leaf, 19 parts of ginkgo leaf and 20 parts of licorice.

Preferably, the traditional Chinese medicine composition for treating eczema according to the present invention mainly consists of the following preparation raw materials in parts by weight: 30 parts of Artemisia argyi leaves, 30 parts of purslane, 22 parts of Nepeta chinensis, 25 parts of white fresh skin, 24 parts of cicada slough, 23 parts of coptis, 23 parts of comfrey, 18 parts of astragalus, 17 parts of cinnamon, 18 parts of albizia flower, 20 parts of night vine, 16 parts of moringa leaf, 15 parts of ginkgo leaf and 15 parts of licorice.

The preparation method of Chinese medicine composition of the present invention comprises the following steps:

S1: Take purslane, wash away impurities, dry and pulverize, pass through a 60-80 mesh sieve, add 8-10 times the total weight of medicinal materials in ethanol with a volume fraction of 60-80%, microwave extraction for 8-15 minutes, microwave power 240-300W, the extraction temperature is 40-60°C, filter and retain the purslane medicinal residue, and concentrate the filtrate under reduced pressure to 60°C to measure the extract with a relative density of 1.20-1.25 to obtain the extract of purslane;

S2: Take Artemisia argyi leaves, Nepeta, Ginkgo biloba, Cicada slough, Coptis chinensis, Comfrey, Astragalus, Cinnamon bark, Albizia julibrissin, Nocturnal vine, Moringa leaves, Ginkgo leaves and licorice, wash away impurities, dry and pulverize, and combine the Purslane medicine dregs, add 15-20 times the amount of coarse powder in water, soak for 20-30 minutes, reflux extraction 2-3 times, 1-3 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to 60 Measure the extract with a relative density of 1.10-1.20 at ℃, cool, slowly add ethanol while stirring until the alcohol content reaches 40-60%, let stand at 4 ℃ for 12-24 hours, filter and retain the filter residue to obtain filtrate A;

S3: Slowly add 4-6 times the weight of ethanol with a volume fraction of 40-60% to the filter residue obtained in S2 while stirring, let stand at 4°C for 3-5 hours, and filter to obtain filtrate B and filter residue; filter residue is reused Wash with 40-60% ethanol for 2-3 times, collect and combine the washing liquid;

S4: Combine the filtrate A, filtrate B and the washing liquid, mix well, concentrate under reduced pressure to 60°C, and measure the extract with a relative density of 1.20-1.25;

S5: Combine and mix the purslane extract and the extract prepared in S4, and carry out vacuum belt drying at a temperature of 60°C, the drying pressure is -0.08MPa, and the feeding speed is 12L/h. The transmission speed is 28cm/min. After drying, the dry extract is crushed and passed through a 100-200 mesh sieve.

Utilizing modern general Chinese medicine preparation technology, the Chinese medicine composition of the present invention can be made into clinically required finished preparations, such as dosage forms such as paste, gel, cream, ointment or liniment.

The source, nature and flavor, meridian distribution and efficacy of the Chinese medicinal materials used in the Chinese medicine composition of the present invention:

Artemisia argyi: This product is the dried leaf of Artemisia argyi of Compositae; taste is pungent, bitter, warm in nature; returns to spleen, liver, kidney meridians; regulates qi and blood, expels cold-dampness, dispels cold and relieves pain, warms meridians to stop bleeding.

Purslane: This product is the dried whole plant of the annual herb of the family Portulaca oleracea; sour, cold; heat-clearing and detoxifying, dispersing blood and detumescence.

Schizonepeta: This product is the dried aboveground part of Nepeta chinensis of Lamiaceae; pungent in taste, slightly warm in nature; returns to lung and liver meridian; relieves exterior and dispels wind, and penetrates rash.

Radix Radix Cortex: This product is the dry root bark of Radix Radix Radix Rutaceae plant; Bitter in the mouth, cold in nature; returns spleen, stomach, bladder meridian; clears away heat and dampness, expelling wind and relieving itching, detoxification.

Cicada slough: This product is the shell shed by the larvae of Cicadae insects, black grasshoppers when they emerge; sweet in taste, cold in nature; returns to the lung and liver meridian; dispels wind and heat, relieves throat, clears rash, relieves nebula, and relieves spasm.

Coptis: This product is the dried rhizome of Coptis chinensis, Coptidis triangularis or Yunlian of Ranunculaceae; bitter in taste, cold in nature; Guixin, spleen, stomach, liver, gallbladder, large intestine meridian; heat-clearing and damp-drying, purging fire and detoxifying.

Comfrey: This product is the dry root of Xinjiang Comfrey, Comfrey or Inner Mongolia Comfrey; sweet, salty, cold in nature; heart-guiding, liver meridian; cooling blood, promoting blood circulation, detoxifying and penetrating rash.

Astragalus: This product is the root of the leguminous plant Astragalus safflower; sweet in taste, warm in nature; Guixin, lung, spleen, and kidney meridian; invigorating qi and strengthening the exterior, diuretic, supporting toxin and expulsion of pus, promoting muscle regeneration and astringing sores.

Cinnamon bark: This product is the bark of Lauraceae plants such as Tianzhugui, Yinxiang, Xiyexianggui or Chuangui; it is pungent, sweet, and warm in nature; it returns to the spleen, stomach, liver, and kidney channels; Cold for relieving pain, dissipating blood stasis and detumescence.

Albizia Julibrissin: This product is the dried inflorescence of Albizia juliensis of leguminous plant; sweet in taste, flat in nature; heart-guiding and liver meridian; relieving depression, regulating qi, calming the nerves and activating collaterals.

Yejiaoteng: It is the cane or leafy cane of Polygonum Polygoni Multiflori Polygonum in the family Polygonaceae; sweet, slightly bitter, flat in nature; heart-guiding and liver meridian; nourishing the heart and calming the nerves, expelling wind, and dredging collaterals.

Moringa leaf: This product is the dry leaves of the perennial tropical deciduous tree Moringa tree (also known as the drumstick tree). Improve sleep and other effects.

Ginkgo biloba: This product is the dried leaves of Ginkgo biloba plant; sweet, bitter, astringent, flat; heart-guiding, lung meridian; promoting blood circulation and removing blood stasis, dredging collaterals to relieve pain, astringing lungs to relieve asthma, reducing turbidity and reducing fat.

Licorice: This product is the dried root of leguminous licorice, licorice inflating or licorice glabra. Sweet in taste, calm in nature; Guixin, lung, spleen, and stomach meridian; invigorating the spleen and replenishing qi, clearing away heat and detoxification, and harmonizing various medicines.

The prescription analysis of Chinese medicine prescription of the present invention:

The traditional Chinese medicine composition of the present invention is to take Artemisia argyi, Schizonepeta, and purslane as monarch drugs, warming middle-JIAO pain relief, detoxifying and relieving itching; taking D. chinensis, cicada slough, Coptis chinensis, and comfrey as ministerial drugs, detoxifying and penetrating rash, clearing heat and drying dampness, Purging fire and detoxifying; using Nocturna vine, astragalus, cinnamon bark, acacia, Moringa leaf, and ginkgo biloba as adjuvant medicines, nourishing the heart and tranquilizing the nerves, supporting toxins and expulsion of pus; using licorice as an envoy, nourishing the spleen and Qi, clearing away heat and detoxification, and harmonizing The properties of various medicines make the combination of various medicines jointly achieve the effects of sterilizing and relieving itching, detoxifying and penetrating rashes, removing toxins and discharging pus, promoting muscle growth and suppressing sores, and has a significant therapeutic effect on eczema.

Through clinical test verification, the traditional Chinese medicine composition of the present invention has the following advantages compared with existing medicines:

1) The present invention can significantly improve the symptoms of eczema, has quick onset, short treatment course, and can inhibit secondary infection.

2) The Chinese medicine composition of the present invention is a natural pure Chinese medicine preparation, has little toxic and side effects, and is non-irritating to the skin.

3) The traditional Chinese medicine composition of the present invention has a strong synergistic effect, a small dosage and no drug dependence.

detailed description

The present invention is further described by specific examples below, and the present invention is not limited only to the following examples. Within the scope of the present invention or without departing from the content, spirit and scope of the present invention, changes, combinations or substitutions to the present invention are obvious to those skilled in the art and are included in the scope of the present invention Inside.

Example 1

The Chinese medicine composition of Example 1 of the present invention mainly consists of the following preparation raw materials in parts by weight:

26 parts of mugwort leaves, 24 parts of purslane, 19 parts of nepeta, 20 parts of white fresh skin, 18 parts of cicada slough, 17 parts of berberine, 19 parts of comfrey, 14 parts of astragalus, 13 parts of cinnamon, 16 parts of Albizia juliensis, night vine 15 parts, Moringa leaf 12 parts, Ginkgo biloba 13 parts and licorice 10 parts.

Preparation:

S1: Take purslane, wash away impurities, dry and crush, pass through a 60-mesh sieve, add 10 times the total weight of medicinal materials in ethanol with a volume fraction of 60%, and extract by microwave for 8 minutes with a microwave power of 240W and an extraction temperature of 40°C , filter and retain the purslane medicine dregs, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.20 measured at 60° C., and obtain a purslane extract;

S2: Take Artemisia argyi leaves, Nepeta, Ginkgo biloba, Cicada slough, Coptis chinensis, Comfrey, Astragalus, Cinnamon bark, Albizia julibrissin, Nocturnal vine, Moringa leaves, Ginkgo leaves and licorice, wash away impurities, dry and pulverize, and combine the Purslane medicinal dregs, add 15 times of the total amount of coarse powder in water, soak for 30 minutes, reflux extraction twice, each time for 3 hours, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to 60°C to measure the relative density of 1.10 extract, cool, slowly add ethanol while stirring until the alcohol content reaches 40%, let it stand at 4°C for 24 hours, filter and retain the filter residue to obtain filtrate A;

S3: Slowly add 4 times the weight of ethanol with a volume fraction of 60% to the filter residue obtained in S2 while stirring, let it stand at 4°C for 5 hours, and filter to obtain filtrate B and filter residue; the filter residue is washed with 60% ethanol for 3 Collect and combine the washing solution;

S4: Combine the filtrate A, filtrate B and the washing liquid, mix well, concentrate under reduced pressure to 60°C, and measure the extract with a relative density of 1.20;

S5: Combine and mix the purslane extract and the extract prepared in S4, and carry out vacuum belt drying at a temperature of 60°C, the drying pressure is -0.08MPa, and the feeding speed is 12L/h. The conveying speed is 28cm/min, after drying, the dry extract is pulverized, and passed through a 100-mesh sieve to obtain the fine powder of the Chinese medicine composition of the present invention;

S6: Add carbomer and emulsifier polysorbate into enough water to soak for 30 hours to make carbomer fully moisten, then add sodium citrate and glacial acetic acid to adjust its pH value to 7.5, and mix well to obtain gel matrix;

S7: Dissolve the fine powder of the Chinese medicine composition of the present invention prepared in S5 in water, sequentially add glycerin, butylene glycol, and the fine powder solution of the Chinese medicine composition of the present invention into the gel matrix, and stir evenly to obtain the Chinese medicine of the present invention Composition gel.

Example 2

The traditional Chinese medicine composition of embodiment 2 of the present invention is mainly made up of the preparation raw material of following parts by weight:

35 parts of mugwort leaves, 33 parts of purslane, 24 parts of nepeta, 27 parts of white fresh skin, 26 parts of cicada slough, 25 parts of berberine, 26 parts of comfrey, 20 parts of astragalus, 20 parts of cinnamon, 21 parts of albizia flower, vine 22 parts, Moringa leaf 18 parts, Ginkgo biloba 19 parts and licorice 20 parts.

Preparation:

S1: Take purslane, wash away impurities, dry it, crush it, pass through an 80-mesh sieve, add ethanol with a volume fraction of 80% in an amount 8 times the total weight of medicinal materials, and extract with microwave for 15 minutes at a microwave power of 300W and an extraction temperature of 60°C , filter and retain the purslane medicine dregs, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.25 measured at 60° C., and obtain a purslane extract;

S2: Take Artemisia argyi leaves, Nepeta, Ginkgo biloba, Cicada slough, Coptis chinensis, Comfrey, Astragalus, Cinnamon bark, Albizia julibrissin, Nocturnal vine, Moringa leaves, Ginkgo leaves and licorice, wash away impurities, dry and pulverize, and combine the Purslane medicinal dregs, add 20 times the amount of coarse powder in water, soak for 20 minutes, reflux extraction 3 times, each time for 1 hour, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to 60 ° C to measure the relative density of 1.20 extract, cool, slowly add ethanol while stirring until the alcohol content reaches 60%, let stand at 4°C for 12 hours, filter and retain the filter residue to obtain filtrate A;

S3: Slowly add 6 times the weight of ethanol with a volume fraction of 40% to the filter residue obtained in S2 while stirring, let it stand at 4°C for 3 hours, and filter to obtain filtrate B and filter residue; the filter residue is washed with 60% ethanol for 2 Collect and combine the washing solution;

S4: Combine the filtrate A, filtrate B and the washing solution, mix well, concentrate under reduced pressure to 60°C, and measure the extract with a relative density of 1.25;

S5: Combine and mix the purslane extract and the extract prepared in S4, and carry out vacuum belt drying at a temperature of 60°C, the drying pressure is -0.08MPa, and the feeding speed is 12L/h. The conveying speed is 28cm/min, after drying, the dry extract is pulverized, and passed through a 200-mesh sieve to obtain the fine powder of the Chinese medicine composition of the present invention;

S6: Put sodium carboxymethyl cellulose in a mortar, add glycerin and grind it evenly, then add the ethanol solution of ethylparaben while grinding, grind it evenly after swelling, and divide the fine powder of the traditional Chinese medicine composition prepared in S5 Add once, grind evenly, obtain the ointment of Chinese medicine composition of the present invention.

Example 3

Embodiment 3 of the present invention Chinese medicine composition comprises the preparation raw material of following parts by weight:

30 parts of mugwort leaf, 30 parts of purslane, 22 parts of nepeta, 25 parts of white fresh skin, 24 parts of cicada slough, 23 parts of berberine, 23 parts of comfrey, 18 parts of astragalus, 17 parts of cinnamon, 18 parts of Albizia juniper, and vine 20 parts, Moringa leaf 16 parts, Ginkgo biloba 15 parts and licorice 15 parts.

Preparation:

S1: Take purslane, wash away impurities, dry and pulverize, pass through an 80-mesh sieve, add 9 times the total weight of medicinal materials, and add ethanol with a volume fraction of 70%, microwave extraction for 10 minutes, the microwave power is 280W, and the extraction temperature is 50°C , filter and retain the purslane medicine dregs, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.20 measured at 60° C., and obtain a purslane extract;

S2: Take Artemisia argyi leaves, Nepeta, Ginkgo biloba, Cicada slough, Coptis chinensis, Comfrey, Astragalus, Cinnamon bark, Albizia julibrissin, Nocturnal vine, Moringa leaves, Ginkgo leaves and licorice, wash away impurities, dry and pulverize, and combine the Purslane medicine dregs, add 18 times the amount of water of the total amount of coarse powder, soak for 25 minutes, reflux extraction 3 times, each time for 1 hour, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to 60 ° C to measure the relative density of 1.20 extract, cool, slowly add ethanol while stirring until the alcohol content reaches 50%, let stand at 4°C for 24 hours, filter and retain the filter residue to obtain filtrate A;

S3: Slowly add 5 times the weight of ethanol with a volume fraction of 50% to the filter residue obtained in S2 while stirring, let it stand at 4°C for 4 hours, and filter to obtain filtrate B and filter residue; the filter residue is washed with 50% ethanol for 3 Collect and combine the washing solution;

S4: Combine the filtrate A, filtrate B and the washing liquid, mix well, concentrate under reduced pressure to 60°C, and measure the extract with a relative density of 1.20;

S5: Combine and mix the purslane extract and the extract prepared in S4, and carry out vacuum belt drying at a temperature of 60°C, the drying pressure is -0.08MPa, and the feeding speed is 12L/h. The conveying speed is 28cm/min, after drying, the dry extract is pulverized, and passed through a 200-mesh sieve to obtain the fine powder of the Chinese medicine composition of the present invention;

S6: Put sodium carboxymethyl cellulose in a mortar, add glycerin and grind it evenly, then add the ethanol solution of ethylparaben while grinding, grind it evenly after swelling, and divide the fine powder of the traditional Chinese medicine composition prepared in S5 Add once, grind evenly, obtain the ointment of Chinese medicine composition of the present invention.

Pharmacodynamic study of Chinese medicine composition of the present invention:

Test 1: the research test of the traditional Chinese medicine composition of the present invention on mice with ear eczema.

Experimental animals: 50 clean-grade Kunming mice provided by a biotechnology company, weighing 22g±4g, half male and half male. 50 mice were randomly divided into 5 groups, 10 in each group.

Ear eczema mouse model establishment: on the first day, smear 40 μL of 5% dinitrochlorobenzene (DNCB) solution on both sides of the mouse’s ears for sensitization, on the fourth day, apply 40 μL of 1% DNCB solution, and then every four days Apply once a time, 5 times in total, to establish ear eczema mouse model.

Dosing regimen:

Group A: Get the Chinese medicine composition gel of the present invention prepared in Example 1 of the present invention; 24h, 48h, and 72h after each smearing of DNCB excitation, externally apply test medicine on the inside of both ears of mice, 1g/each time, 2 times /sky.

Group B: take the traditional Chinese medicine composition ointment of the present invention prepared in Example 2 of the present invention; the administration regimen is the same as that of Group A.

Group C: take the traditional Chinese medicine composition ointment of the present invention prepared in Example 3 of the present invention; the administration regimen is the same as that of Group A.

Positive control group: take compound dexamethasone cream (Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Baiyunshan Hejigong Pharmaceutical Factory, National Pharmaceutical Approval H44024298), and the administration regimen is the same as that of group A.

Model control group: the drug-free gel in Example 1 of the present invention was taken, and the administration regimen was the same as that of group A.

Score the degree of skin lesions according to the following criteria: 3 points for obvious redness, swelling, thickening and oozing of both ears, or obvious keratosis and scab; 2 points for mild redness, no obvious oozing, or moderate keratosis ; Redness and exudation are not obvious, or mild keratosis recorded as 1 point; normal skin is 0 points.

At the same time, the ear swelling thickness was measured separately using a screw micrometer.

Table 1 Comparison of ear skin lesions in each group

Note: Compared with the model control group, ^* P0.05; ^** P0.01.

Compared with the model control group, the drug test group had significant differences in ear skin lesion score and ear swelling thickness. The test data shows that compared with the mice in the model control group, the skin lesions in the ears of the mice in the drug test group are significantly better, and the degree of ear swelling is significantly reduced. The curative effect of the traditional Chinese medicine composition is equivalent to that of the positive control group. The test results show that the traditional Chinese medicine composition of the invention has obvious effects in treating and preventing eczema, and can be used for clinical promotion.

Test two: the clinical test of the traditional Chinese medicine composition of the present invention.

1. Diagnostic criteria

It is formulated with reference to the content of "Diagnostic Basis of Eczema" in "Diagnostic and Curative Criteria for Diseases and Syndromes of Traditional Chinese Medicine". The diagnostic criteria are:

1. Acute eczema

1) The skin lesions are pleomorphic, such as flushing, papules, blisters, erosions, exudations, crusts, and desquamation, and multiple forms exist at the same time.

2) Acute onset, conscious burning, severe itching.

3) Skin lesions are often distributed symmetrically, and are more common on the head, face, distal extremities, and scrotum. Can be distributed all over the body.

4) It can develop into subacute or chronic eczema, which is sometimes mild and sometimes severe, and does not heal repeatedly.

2. Subacute eczema: less exudation of skin lesions, mainly papules, papules, scabs, and scales. There is a mildly erosive surface, and the color is darker red. Mild infiltration and severe itching can also be seen.

3. Chronic eczema: mostly limited to a certain part, with clear boundary, obvious hypertrophy and infiltration, rough surface, or lichen-like changes, brownish red or brown in color, often accompanied by papules, scabs, and scratches. It tends to be moist and changes, often recurrent, sometimes mild and sometimes severe, with paroxysmal itching.

2. Clinical trial plan

1. Basic information of test subjects

The present invention collects 100 clinical eczema volunteers, 52 males, 48 females, aged 16-45 years old, all subjects are randomly divided into 2 groups, 50 in each group, 2 groups of cases in terms of gender, age, course of disease And so on by statistical analysis, comparable.

2. Test drugs and test methods

Treatment group: the ointment prepared by Example 3 of the present invention, each ointment contains 12.5g of medicine, applied on the eczema, twice a day, continuously for 10 days.

Positive control group: apply compound dexamethasone cream (Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Baiyunshan Hejigong Pharmaceutical Factory, National Pharmaceutical Approval H44024298), twice a day, for 10 consecutive days.

3. Curative effect standard

Effective: Eczema erythema is significantly reduced, and the number of attacks is reduced.

Ineffective: Compared with before treatment, the symptoms did not disappear or aggravated instead.

Recurrence: 3 months after being cured, it still occurs in hot and humid climate.

4. Treatment results, as shown in Table 2

Table 2 Treatment effect

Number of cases valid (example) invalid (example) recurrence (example) total effective rate therapy group 50 47 3 1 94.0% positive control group 50 45 5 5 90.0%

The test results show that the effect of the traditional Chinese medicine composition of the present invention in treating eczema in the treatment group is better than that of the positive control drug compound dexamethasone cream. Compared with the positive control group in the treatment group, the total effective rate of the treatment group was 94.0% higher than the total effective rate of 90.0% in the positive control group, and the number of recurrences in the treatment group was significantly lower than that of the positive control group. According to observation, the patients in the treatment group did not see any adverse reactions during the course of treatment. The traditional Chinese medicine composition of the invention has quick onset of effect for treating eczema, high safety, low recurrence rate and high clinical popularization value.

Claims (6)

1. treat a Chinese medicine composition for eczema, it is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following weight portion:

Folium Artemisiae Argyi 26-35 part, Herba Portulacae 24-33 part, Herba Schizonepetae 19-24 part, Cortex Dictamni 20-27 part, Periostracum Cicadae 18-26 part, Rhizoma Coptidis 17-25 part, Radix Arnebiae (Radix Lithospermi) 19-26 part, Radix Astragali 14-20 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 13-20 part, Flos Albiziae 16-21 part, Caulis Polygoni Multiflori 15-22 part, leaf of Moringa 12-18 part, Folium Ginkgo 13-19 part and Radix Glycyrrhizae 10-20 part.

2. the Chinese medicine composition for the treatment of eczema according to claim 1, is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following parts by weight:

Folium Artemisiae Argyi 26 parts, Herba Portulacae 24 parts, Herba Schizonepetae 19 parts, Cortex Dictamni 20 parts, Periostracum Cicadae 18 parts, Rhizoma Coptidis 17 parts, Radix Arnebiae (Radix Lithospermi) 19 parts, the Radix Astragali 14 parts, 13 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 16 parts, Caulis Polygoni Multiflori 15 parts, leaf of Moringa 12 parts, Folium Ginkgo 13 parts and 10 parts, Radix Glycyrrhizae.

3. the Chinese medicine composition for the treatment of eczema according to claim 1, is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following parts by weight:

Folium Artemisiae Argyi 35 parts, Herba Portulacae 33 parts, Herba Schizonepetae 24 parts, Cortex Dictamni 27 parts, Periostracum Cicadae 26 parts, Rhizoma Coptidis 25 parts, Radix Arnebiae (Radix Lithospermi) 26 parts, the Radix Astragali 20 parts, 20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 21 parts, Caulis Polygoni Multiflori 22 parts, leaf of Moringa 18 parts, Folium Ginkgo 19 parts and 20 parts, Radix Glycyrrhizae.

4. the Chinese medicine composition for the treatment of eczema according to claim 1, is characterized in that, described Chinese medicine composition forms primarily of the raw materials of following parts by weight:

Folium Artemisiae Argyi 30 parts, Herba Portulacae 30 parts, Herba Schizonepetae 22 parts, Cortex Dictamni 25 parts, Periostracum Cicadae 24 parts, Rhizoma Coptidis 23 parts, Radix Arnebiae (Radix Lithospermi) 23 parts, the Radix Astragali 18 parts, 17 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae 18 parts, Caulis Polygoni Multiflori 20 parts, leaf of Moringa 16 parts, Folium Ginkgo 15 parts and 15 parts, Radix Glycyrrhizae.

5., according to the Chinese medicine composition of the arbitrary described treatment eczema of claim 1-4, it is characterized in that, described Chinese medicine composition is made into paste, gel, ointment, ointment or liniment.

6., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment eczema of claim 1-4, it is characterized in that, the preparation method of described Chinese medicine composition comprises following steps:

S1: get Herba Portulacae, wash away impurity, crushed after being dried, cross 60-80 mesh sieve, adding medical material gross weight 8-10 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 240-300W, and Extracting temperature is 40-60 DEG C, filters and retains Herba Portulacae medicinal residues, the extractum that relative density is 1.20-1.25 is surveyed, obtained Herba portulacae extract at filtrate reduced in volume to 60 DEG C;

S2: get Folium Artemisiae Argyi, Herba Schizonepetae, Cortex Dictamni, Periostracum Cicadae, Rhizoma Coptidis, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Flos Albiziae, Caulis Polygoni Multiflori, leaf of Moringa, Folium Ginkgo and Radix Glycyrrhizae, wash away impurity, crushed after being dried, merge described Herba Portulacae medicinal residues, add the water of coarse powder total amount 15-20 times amount, soak 20-30 minute, reflux, extract, 2-3 time, each 1-3 hour, filter, merging filtrate, the extractum that relative density is 1.10-1.20 is surveyed at filtrate reduced in volume to 60 DEG C, cooling, slowly add ethanol while stirring to alcohol content for reaching 40-60%, 4 DEG C of standing 12-24 hour, filter and retain filtering residue, obtain filtrate A,

S3: the filtering residue obtained in S2 slowly being added while stirring its weight 4-6 times amount volume fraction is the ethanol of 40-60%, 4 DEG C of standing 3-5 hour, filters, obtains liquor B and filtering residue; Filtering residue uses the washing with alcohol 2-3 time of 40-60% again, collects and merges cleaning mixture;

S4: merge described filtrate A, liquor B and cleaning mixture, surveys extractum that relative density be 1.20-1.25 under being evaporated to 60 DEG C of conditions after mixing;

S5: extractum obtained in described Herba portulacae extract and S4 is merged mixing, and carry out vacuum belt type drying at 60 DEG C of temperature, drying pressure is-0.08MPa, charging rate is 12L/h, and material strip transfer rate is 28cm/min, is pulverized by dry extract after drying, cross 100-200 mesh sieve, to obtain final product.