CN101940652A - Chinese medicinal liniment for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus - Google Patents
Chinese medicinal liniment for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus Download PDFInfo
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- CN101940652A CN101940652A CN2010102688501A CN201010268850A CN101940652A CN 101940652 A CN101940652 A CN 101940652A CN 2010102688501 A CN2010102688501 A CN 2010102688501A CN 201010268850 A CN201010268850 A CN 201010268850A CN 101940652 A CN101940652 A CN 101940652A
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- 208000003251 Pruritus Diseases 0.000 title claims abstract description 24
- 201000004624 Dermatitis Diseases 0.000 title claims abstract description 23
- 201000004681 Psoriasis Diseases 0.000 title claims abstract description 23
- 239000000865 liniment Substances 0.000 title claims abstract description 14
- 229940040145 liniment Drugs 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 244000130592 Hibiscus syriacus Species 0.000 claims abstract description 11
- 235000018081 Hibiscus syriacus Nutrition 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 6
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- 239000003018 immunosuppressive agent Substances 0.000 abstract description 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
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Abstract
The invention relates to a Chinese medicinal liniment for treating psoriasis, multiple kinds of stubborn dermatitis and pruritus. At present, most medicaments for treating the psoriasis, multiple kinds of stubborn dermatitis and pruritus belong to immunosuppressive agents and have the adverse effect on the normal immunologic function. The Chinese medicinal liniment comprises the following medicaments by weight: 90 to 110 grams of rhubarb, 140 to 160 grams of pricklyash peel, 40 to 60 grams of Chinese mugwort leaf, 90 to 110 grams of lightyellow sophora root, 90 to 110 grams of shrubalthea bark, 70 to 90 grams of garden balsam stem, 140 to 160 grams of chaulmoogratree seed and 90 to 110 grams of erythrina indica lam. A preparation method comprises the following steps of: grinding the Chinese medicinal herbs into 150 to 200-mesh powder, adding 1,000 milliliters of 95 percent ethanol for stirring, and immersing the mixture for 24 hours; and extracting filter liquor, adding 4,000 milliliters of 50 percent ethanol into filter residues for stirring, immersing the mixture for 24 hours, extracting filter liquor, merging the two-time filter liquor, and mixing uniformly for packaging to obtain the Chinese medicinal liniment. The Chinese medicinal liniment is used for treating the psoriasis, multiple kinds of stubborn dermatitis and pruritus.
Description
Technical field:
The present invention relates to a kind of Traditional Chinese medicine liniment for the treatment of psoriasis, various stubborn dermatitis, pruritus.
Background technology:
Psoriasis, various stubborn dermatitis, pruritus are very common chronic dermatosis.Doctor trained in Western medicine it be unclear that the psoriasic cause of disease, does not also have a kind of medicine at present and can reach radical cure.Many patients when treatment psoriasis, various stubborn dermatitis, pruritus owing to do not follow the medication requirement, not only do not improve disease symptoms, missed best treatment opportunity on the contrary, treatment time is long, the medicine of treatment belongs to the immunosuppressant class mostly at present, and normal immunologic function is had harmful effect, if the blindness long-term prescription, can make the lower for the resistance of patient, have a strong impact on treatment.
Present medicine and method mainly contain following several
1. steroid hormone: corticosteroid hormone ointment (frost) external has 20 years history.Potent steroid hormone ointment (frost) external cleaning, instant effect, but drug withdrawal easily recurs, the life-time service side effect increases, so a lot of doctor's tendency need not, or only short-term, be interrupted and use.The intensity of medicine has very big difference, from the mild to the super strong type.The intensity of hormone has determined how long the skin in which zone can not have side effects with using in medication.Excessively use the common side effect in back to comprise thinning of skin, stretch cicatrix and the Drug resistance of this hormone.
2. suppress DNA class medicine: its side effect is little, but the normal skin around the psoriatic lesion that can stimulate or burn.
3. phototherapy (UVB): under doctor's specialized guidance, treat psoriatic lesion general hair style or local obstinate type with Type B ultraviolet (UVB).Can unite use with the external medication method.There is very little risk to use UVB in a short time.The risk of life-time service UVB is the same with being exposed to the sun in the sun: skin carcinoma and skin aging.Short-term use the side effect of PUVA common stomach discomfort arranged, skin rubefaction is itched.Life-time service can increase the trouble skin splash, skin senilism, the chance of cataract etc.Repeatedly investigation to the patient that accepts PUVA treatment for a long time shows, can cause suffering from the risk of some skin carcinoma after life-time service PUVA therapy.
Above-mentioned treatment medicine and method mainly are to eliminate symptom, avoid further deterioration, can't effect a radical cure.Side effect is bigger, uses and wants prudent.
Summary of the invention:
The purpose of this invention is to provide a kind of Traditional Chinese medicine liniment for the treatment of psoriasis, various stubborn dermatitis, pruritus, evident in efficacy, and the difficult recurrence in recovery from illness back, the patient no longer needs the life-time service medicine to keep, and does not develop immunity to drugs.
Above-mentioned purpose realizes by following technical scheme:
The treatment psoriasis, various stubborn dermatitis, the Traditional Chinese medicine liniment of pruritus, its composition comprises: Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Shrubalthea Bark, Herba speranskiae tuberculatae, Semen Hydnocarpi, Cortex erythrinae, its weight is: Radix Et Rhizoma Rhei 90g-110g, Pericarpium Zanthoxyli 140g-160g, Folium Artemisiae Argyi 40g-60g, Radix Sophorae Flavescentis 90g-110g, Shrubalthea Bark 90g-110g, Herba speranskiae tuberculatae 70g-90g, Semen Hydnocarpi 140g-160g, Cortex erythrinae 90g-110g, described Chinese herbal medicine powder is broken into the 150-200 order, adding 95% ethanol 1000ml stirs, flooded 24 hours, extract filtrate, filtering residue adds 50% ethanol 4000ml again and stirs, flooded 24 hours, and extracted filtrate again, merge filtrate twice, the mixing packing, promptly.
Beneficial effect:
1. psoriasis, various stubborn dermatitis, pruritus initial stage are caused by wind, wet, pathogenic heat retardance skin, so that QI-blood circulation loses freely, with the passing of time consume impairment of YIN blood, seek deficiency of YIN, and wind syndrome due to blood-deficiency, dryness-transformation are due to the failure of skin and muscle to be nourished.Then to dispel the wind, heat clearing away, dampness, to nourish blood, the poison that purifies the blood from the source thoroughly changes heat in blood, blood stasis, the dry phenomenon of blood, and opens a mao key, qi and blood circulation promotion, the poison that gets rid of illness, treating both the principal and secondary aspects of a disease method of the present invention.The present invention is by famous and precious natural Chinese medicine, and compatibility forms drug utilization Du Genggao, more remarkable treatment effect meticulously.
2. this product is a kind of externally applied liniment, and effect is good during the treatment, and is evident in efficacy, and the difficult recurrence in recovery from illness back, and the patient no longer needs the life-time service medicine to keep, and does not develop immunity to drugs.
3. this product does not contain additives such as any hormone, Fructus Psoraleae, advantage without any side effects.
4. medicine of the present invention has significant curative effect through the evidence safety non-toxic to the treatment vitiligo, and its toxicology and pharmacodynamic experiment data are as follows:
Skin irritation test: the stimulus intensity to rabbit skin belongs to nonirritant.The skin allergic reaction experiment: sensitization rate 0%, sensitization intensity belong to extremely slightly degree.
Long term toxicity test: respectively with 0.8g/kg, apply medicinal lotion or ointment to rat skin, every day three times, continuous 60 days, result of the test showed that general state, behavioral activity and the diet situation and the matched group that are tried rat do not have significant difference; Hematology, liver function, renal function and organ coefficient and matched group more all do not have significant difference, show that life-time service medicine of the present invention is safe.
5. it is as follows to carry out patient's clinical trial: 150 routine psoriasiss, various stubborn dermatitis, pruritus patient patient offer the degree of minister dermatosis section hospital according to the state of an illness in Harbin, the patient of this medicine of clinical practice is divided into 3 groups, every group 50 people.
1,50 routine psoriasiss, various stubborn dermatitis, pruritus patient are ill in 1 year, and the affected part is at 7cm
2In.Offer minister dermatosis section hospital clinical practice 2 months in Harbin, therapeutic effect sees Table 1:
This medicine of table 1 is to psoriasis, various stubborn dermatitis, pruritus patient's therapeutic effect:
50 routine psoriasiss, various stubborn dermatitis, pruritus patient are ill in 5 years, and the affected part is at 10cm
2In.Offer minister dermatosis section hospital clinical practice 6 months in Harbin, therapeutic effect sees Table 2:
This medicine of table 2 is to psoriasis, various stubborn dermatitis, pruritus patient's therapeutic effect:
50 routine psoriasiss, various stubborn dermatitis, pruritus patient are ill in 10 years, and the affected part is at 50cm
2In.Offer minister dermatosis section hospital clinical practice 8 months in Harbin, therapeutic effect is as follows:
This medicine of table 3 is to psoriasis, various stubborn dermatitis, pruritus patient's therapeutic effect
Patient's clinical manifestation: its symptom is normal or filbert flat little scrofula from the beginning of color of the leather, and the surface is little bright, and of a specified duration increasing gradually merged in flakes, pachyderma, and sulci of skin is deepened, and is dry coarse, is the lichen sample and becomes, and desquamation is very itched, and pain is not known in scratching of having.Also there are the coin of being shape, map shape in sick place, return shape, vesicle is arranged, crowfoot cracks etc. individually.Different parts, symptom differs, and outbreak increases the weight of year by year repeatedly.
The standard of medical effect evaluation: effectively: 1, just sloughed the sclerderm dead bark of body surface, the skin wounds of chapping also begins rapid healing, and pruritus alleviates, and squama reduces.2, the focus area dwindles, and is linked to be large stretch of tinea piece originally and has become isolated one by one red point, and squama further reduces, and the sufferings sense is most of to disappear.3, gloss appears in skin, the basic recovery normally, and scratchiness disappears substantially.4, sufferings sense complete obiteration, cutaneous pigmentation disappears, and it is normal that recover fully at the skin lesion position.
Statistical result: effective 95%, recovery from illness 80%, invalid 5%.
The result shows: medicine of the present invention can obviously be treated psoriasis, various stubborn dermatitis, pruritus.
The specific embodiment:
Embodiment 1:
The treatment psoriasis, various stubborn dermatitis, the Traditional Chinese medicine liniment of pruritus, its composition comprises: Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Shrubalthea Bark, Herba speranskiae tuberculatae, Semen Hydnocarpi, Cortex erythrinae, its weight is: Radix Et Rhizoma Rhei 110g, Pericarpium Zanthoxyli 160g, Folium Artemisiae Argyi 60g, Radix Sophorae Flavescentis 110g, Shrubalthea Bark 90g, Herba speranskiae tuberculatae 70g, Semen Hydnocarpi 140g, Cortex erythrinae 90g, described Chinese herbal medicine powder is broken into the 150-200 order, adding 95% ethanol 1000ml stirs, flooded 24 hours, extract filtrate, filtering residue adds 50% ethanol 4000ml again and stirs, flooded 24 hours, and extracted filtrate again, merge filtrate twice, the mixing packing, promptly.
Embodiment 2:
The treatment psoriasis, various stubborn dermatitis, the Traditional Chinese medicine liniment of pruritus, its composition comprises: Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Shrubalthea Bark, Herba speranskiae tuberculatae, Semen Hydnocarpi, Cortex erythrinae, its weight is: Radix Et Rhizoma Rhei 90g, Pericarpium Zanthoxyli 140g, Folium Artemisiae Argyi 40g, Radix Sophorae Flavescentis 90g, Shrubalthea Bark 110g, Herba speranskiae tuberculatae 90g, Semen Hydnocarpi 160g, Cortex erythrinae 110g, described Chinese herbal medicine powder is broken into the 150-200 order, adding 95% ethanol 1000ml stirs, flooded 24 hours, extract filtrate, filtering residue adds 50% ethanol 4000ml again and stirs, flooded 24 hours, and extracted filtrate again, merge filtrate twice, the mixing packing, promptly.
Embodiment 3:
The treatment psoriasis, various stubborn dermatitis, the Traditional Chinese medicine liniment of pruritus, its composition comprises: Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Shrubalthea Bark, Herba speranskiae tuberculatae, Semen Hydnocarpi, Cortex erythrinae, its weight is: Radix Et Rhizoma Rhei 100g, Pericarpium Zanthoxyli 150g, Folium Artemisiae Argyi 50g, Radix Sophorae Flavescentis 100g, Shrubalthea Bark 100g, Herba speranskiae tuberculatae 80g, Semen Hydnocarpi 150g, Cortex erythrinae 100g, described Chinese herbal medicine powder is broken into the 150-200 order, adding 95% ethanol 1000ml stirs, flooded 24 hours, extract filtrate, filtering residue adds 50% ethanol 4000ml again and stirs, flooded 24 hours, and extracted filtrate again, merge filtrate twice, the mixing packing, promptly.
Using method:
With gauze or absorbent cotton, be stained with a small amount of medicinal liquid, massage wiping (helping the absorption of medicine like this) gently in the affected part, preferably liquid medicine can be scalded when use winter, so that give full play to drug effect.Apply medicinal lotion or ointment 2-3 every day, external any time all can, apply medicinal lotion or ointment 2 hours time at least in the affected part every day.The drying at position note to keep applying medicinal lotion or ointment.Do not exert oneself very much when applying medicinal lotion or ointment, in order to avoid cause skin injury.
Claims (1)
1. treat psoriasis for one kind, various stubborn dermatitis, the Traditional Chinese medicine liniment of pruritus, its composition comprises: Radix Et Rhizoma Rhei, Pericarpium Zanthoxyli, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Shrubalthea Bark, Herba speranskiae tuberculatae, Semen Hydnocarpi, Cortex erythrinae, it is characterized in that: its weight is: Radix Et Rhizoma Rhei 90g-110g, Pericarpium Zanthoxyli 140g-160g, Folium Artemisiae Argyi 40g-60g, Radix Sophorae Flavescentis 90g-110g, Shrubalthea Bark 90g-110g, Herba speranskiae tuberculatae 70g-90g, Semen Hydnocarpi 140g-160g, Cortex erythrinae 90g-110g, described Chinese herbal medicine powder is broken into the 150-200 order, adding 95% ethanol 1000ml stirs, flooded 24 hours, extract filtrate, filtering residue adds 50% ethanol 4000ml again and stirs, flooded 24 hours, extract filtrate again, merge filtrate twice, the mixing packing.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920829A (en) * | 2012-11-28 | 2013-02-13 | 陈丽芳 | Drug for treating psoriasis and preparation method thereof |
| WO2017146368A1 (en) * | 2016-02-25 | 2017-08-31 | 대구한의대학교산학협력단 | Composition for preventing or treating skin pruritus containing kalopanax pictus extract as active ingredient |
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|---|---|---|---|---|
| CN101049368A (en) * | 2007-05-12 | 2007-10-10 | 韩艳军 | Oral and external remedy for curing psoriasis |
| CN101301354A (en) * | 2008-04-03 | 2008-11-12 | 魏芸 | Externally used medicinal liquor for treating psoriasis |
| CN101569703A (en) * | 2008-04-30 | 2009-11-04 | 王卿荣 | Traditional chinese medicine lotion |
| CN101623373A (en) * | 2009-08-14 | 2010-01-13 | 周大红 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
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2010
- 2010-09-01 CN CN201010268850.1A patent/CN101940652B/en not_active Expired - Fee Related
Patent Citations (4)
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| CN101049368A (en) * | 2007-05-12 | 2007-10-10 | 韩艳军 | Oral and external remedy for curing psoriasis |
| CN101301354A (en) * | 2008-04-03 | 2008-11-12 | 魏芸 | Externally used medicinal liquor for treating psoriasis |
| CN101569703A (en) * | 2008-04-30 | 2009-11-04 | 王卿荣 | Traditional chinese medicine lotion |
| CN101623373A (en) * | 2009-08-14 | 2010-01-13 | 周大红 | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920829A (en) * | 2012-11-28 | 2013-02-13 | 陈丽芳 | Drug for treating psoriasis and preparation method thereof |
| WO2017146368A1 (en) * | 2016-02-25 | 2017-08-31 | 대구한의대학교산학협력단 | Composition for preventing or treating skin pruritus containing kalopanax pictus extract as active ingredient |
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| Publication number | Publication date |
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| CN101940652B (en) | 2014-02-26 |
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