CN105343496A - Traditional Chinese medicine composition for treating eczema and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating eczema and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and relates to a traditional Chinese medicine composition for treating eczema. The traditional Chinese medicine composition is mainly prepared from, by weight, 15-30 parts of Radix ophiopogonis, 10-25 parts of Herba schizonepeta, 10-20 parts of Cortex dictamni, 10-25 parts of cicada slough, 15-25 parts of Radix lithospermi, 10-15 parts of Radix astragali, 5-20 parts of cassia bark, 10-20 parts of Caulis polygoni multiflori, 10-18 parts of Radix paeoniae alba and 5-15 parts of Radix glycyrrhizae. The traditional Chinese medicine composition has the advantages of quick action on stopping itch, good treatment effect and freeness of skin irritation in the aspect of treating eczema, a preparation process is simple, convenient and easy to implement, the traditional Chinese medicine composition has stable efficacy, a patient is high in drug compliance, and the traditional Chinese medicine composition is wide in application range and easy for popularization and application.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of eczema and preparation method thereof.
Background technology
Eczema is a kind of common allergic inflammation dermatoses, and its feature is pleomorphism erythra, oozes out tendency, symmetrical, is easy to recurrence and chronicity.More eczematosis, because of more complicated, thought anaphylactic disease at present, is belonged to type Ⅳ allergy.Anaphylactogen can from the external world, also can from internal body.Enviromental allergen as the toxin of chemical drugs, cosmetics, dyestuff, some animal, foreign preteins and some pollen, the dust etc. such as egg, fish, shrimp, milk.Inner anaphylactogen is as internal lesions, and intestinal parasitic disease, some metabolism, endocrine or digestive tract function imbalance and human body itself are under some is organized in the impact of some factor, and its composition changes and forms autoantibody etc.
The traditional Chinese medical science thinks that this disease is strong mainly due to disease just taste mistake, endogenous dampness, strongly fragrant heat-transformation of a specified duration, retention of damp-heat in the interior, and then rash color is scarlet for outer more skin, contamination flow liquid, and disease is recurrent exerbation for a long time, and cloudy blood is consumed; Qi-blood disharmony, the raw wind of dryness-transformation, failure of skin and muscle to be nourished, coarse plumpness, touching difficulty more.In a word, this disease belongs to damp and hot, and heat in blood, dampness, caused by blood is dry.Clinical should according to the body constitution of patient, arteries and veins card, Selection drug, can not adhere rigidly to into side.
Western medical treatment is based on antihistamine drug for oral administration, medicine for external use is mainly selected the soaks such as solution, lotion, paste or ointment according to different stadium performance or is coated with outward, when there is secondary infection, can consider to use antibiotic therapy, but there is larger toxic and side effects to skin in some Western medicine, the simultaneously treatment such as antibiotic, hormone not only directly can affect the health of patient, and long period or short-term heavy dose use, and addiction also can cause drug dependence dermatitis.
Chinese patent application 201210287998.9 discloses a kind of application compress for the treatment of eczema, this medicine is by being immersed in the rice vinegar through boiling cooling respectively by Rhizoma Smilacis Glabrae, Fructus Forsythiae, Herba Schizonepetae, Folium Artemisiae Argyi, Mirabilitum, Herba speranskiae tuberculatae, Radix Glycyrrhizae, Pericarpium Zanthoxyli Chinese crude drug, inoculate acetobacter, when different fermentations after indirect fermentation, again its fermentation liquid is blent and make, this medicine has certain curative effect in treatment eczema, but this process for preparing medicine is complicated, and treatment is longer for the course for the treatment of.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of eczema, and this Chinese medicine composition can Quick itch stopping, and pointed strong, advantage that good effect, relapse rate are low, has good long-term effect.
In addition, the present invention also provides the preparation technology of this Chinese medicine composition, on the basis ensureing curative effect, Chinese medicine is made universality is strong, be easy to carry about with one the finished product preparation used.
The Chinese medicine composition for the treatment of eczema of the present invention is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 15-30 part, Herba Schizonepetae 10-25 part, Cortex Dictamni 10-20 part, Periostracum Cicadae 10-25 part, Radix Arnebiae (Radix Lithospermi) 15-25 part, Radix Astragali 10-15 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5-20 part, Caulis Polygoni Multiflori 10-20 part, Radix Paeoniae Alba 10-18 part and Radix Glycyrrhizae 5-15 part.
Preferably, described Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 15 parts, Herba Schizonepetae 10 parts, Cortex Dictamni 10 parts, Periostracum Cicadae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, the Radix Astragali 10 parts, 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 10 parts, the Radix Paeoniae Alba 10 parts and 5 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 30 parts, Herba Schizonepetae 25 parts, Cortex Dictamni 20 parts, Periostracum Cicadae 25 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, the Radix Astragali 15 parts, 20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 20 parts, the Radix Paeoniae Alba 18 parts and 15 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 20 parts, Herba Schizonepetae 15 parts, Cortex Dictamni 15 parts, Periostracum Cicadae 15 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, the Radix Astragali 12 parts, 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 15 parts, the Radix Paeoniae Alba 15 parts and 10 parts, Radix Glycyrrhizae.
The preparation method of Chinese medicine composition of the present invention comprises following steps:
S1: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2: take Herba Schizonepetae, Cortex Dictamni, Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, after adding water soaking 12-24 hour of medical material gross weight 5-10 times amount, decoct 2-6 hour, filter, filtering residue adds the 50-80% alcoholic solution of filtering residue gross weight 2-6 times amount, decoct 1-3 hour, filter, merge twice filtrate;
S3: the filtrate mixing described Radix Ophiopogonis extract and S2 obtained, being concentrated into relative density at 50-60 DEG C is the Chinese medical concrete of 1.20-1.35, drying under reduced pressure, crosses 100-200 mesh sieve, obtains Chinese medicine composition of the present invention.
Utilize modern general Chinese medicine preparation technology, Chinese medicine composition of the present invention can be made into the finished product preparation of clinical needs, as dosage forms such as paste, gel, ointment, ointment or liniments.
Source, the nature and flavor of Chinese medicine composition of the present invention Chinese crude drug used, return through and effect:
Radix Ophiopogonis: be the tuber of liliaceous plant Radix Ophiopogonis, Hubei Radix Ophiopogonis, short Roripa mountain wheat or Radix Liriopes, dwarf lilyturf etc.; Sweet, micro-hardship, is slightly cold, GUIXIN, lung, stomach warp.YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, and for dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Can immunologic function be improved, have inhibitory action to various bacteria, pituitary adrenal system function can be strengthened, improve organism adaptation ability, have arrhythmia and the peripheral vascular effect of expansion, can hypoxia-bearing capability be improved, have hypoglycemic activity.
Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae; Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.
Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany; Bitter in the mouth, cold in nature; Return spleen, stomach, urinary bladder channel; Heat clearing and damp drying, dispelling wind for relieving itching, removing toxic substances.
Periostracum Cicadae: exuviae shell when this product is the larva emergence of cicada Cryptotympana atrata Fabr.; Sweet in the mouth, cold in nature; Return lung, Liver Channel; Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.
Radix Arnebiae (Radix Lithospermi): this product is the dry root of comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi) or arnebia guttata Bunge; Sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel; Removing heat from blood, invigorates blood circulation, removing toxic substances rash.
The Radix Astragali: this product is the root of leguminous plant Radix Hedysari multijugi; Sweet in the mouth, warm in nature; GUIXIN, lung, spleen, kidney channel; Invigorating QI to consolidate the body surface resistance, diuresis, expelling pus and toxin by strengthening QI, promoting tissue regeneration and ulcer healing.
Cortex cinnamomi japonici (Ramulus Cinnamomi): this product is the bark in canella Cinnamomum japonica, cloudy perfume, cinnamomum chingii Metcalf or osmanthus, river etc.; Acrid in the mouth, sweet, warm in nature; Return spleen, stomach, liver, kidney channel; Warming the spleen stomach, warm Liver and kidney, cold-dispelling pain-relieving, dissipating blood stasis for subsidence of swelling.
Caulis Polygoni Multiflori: be rattan or the leaf bine stem of polygonum multiflorum thunb; Sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel;
Tranquilizing by nourishing the heart, dispels the wind, dredging collateral.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese medicine composition of the present invention is with Radix Ophiopogonis, Herba Schizonepetae for monarch drug, warming middle-JIAO to relieve pain, detoxifying and relieving itching; With Cortex Dictamni, Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi) for ministerial drug, removing toxic substances rash, heat clearing and damp drying, eliminating fire and detoxication; With Caulis Polygoni Multiflori, the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), the Radix Paeoniae Alba, Rhizoma Zingiberis Recens for adjuvant drug, tranquilizing by nourishing the heart, expelling pus and toxin by strengthening QI; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, makes all medicines arrange in pairs or groups, jointly reaches sterilizing and itch-relieving, and removing toxic substances rash, expelling pus and toxin by strengthening QI, effect of promoting tissue regeneration and ulcer healing, has significant therapeutic effect to eczema.
Through clinical trial checking, Chinese medicine composition of the present invention has following advantage compared with existing medicine: 1) the present invention significantly can improve the symptom of eczema, rapid-action, treatment short treating period, and can suppress secondary infection.2) Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and toxic and side effects is little, to no skin irritation.3) Chinese medicine composition synergism of the present invention is strong, and using dosage is little, can not produce drug dependence simultaneously.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
eXAMPLE l
The embodiment of the present invention 1 Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 15 parts, Herba Schizonepetae 10 parts, Cortex Dictamni 10 parts, Periostracum Cicadae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, the Radix Astragali 10 parts, 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 10 parts, the Radix Paeoniae Alba 10 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is as follows:
S1: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 45% is the alcoholic solution of 75%, and regulation and control carbon dioxide flow is 18L/h, and extracting pressure is 18MPa, extraction temperature is 50 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2: take Herba Schizonepetae, Cortex Dictamni, Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the water soaking of medical material gross weight 6 times amount after 16 hours, decoct 4 hours, filter, filtering residue adds 75% alcoholic solution of filtering residue gross weight 4 times amount, decoct 2 hours, filter, merge twice filtrate;
S3: the filtrate mixing that described Radix Ophiopogonis extract and S2 are obtained, being concentrated into relative density at 60 DEG C is the Chinese medical concrete of 1.25, drying under reduced pressure, crosses 100 mesh sieves, obtains Chinese medicine composition of the present invention;
S4: carbomer and emulsifying agent Polysorbate are added enough water soakings 24 hours, carbomer is moistened completely rise, add sodium citrate again and glacial acetic acid regulates its pH value to be 7.5, mix homogeneously, obtained gel-type vehicle, the Chinese medicine composition that S3 is obtained is soluble in water, joins in gel-type vehicle successively by glycerol and butanediol, Chinese medicine composition solution, stir, obtain Chinese medicine composition gelata of the present invention.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 30 parts, Herba Schizonepetae 25 parts, Cortex Dictamni 20 parts, Periostracum Cicadae 25 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, the Radix Astragali 15 parts, 20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 20 parts, the Radix Paeoniae Alba 18 parts and 15 parts, Radix Glycyrrhizae.
Preparation method is similar to Example 1.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight: Radix Ophiopogonis 20 parts, Herba Schizonepetae 15 parts, Cortex Dictamni 15 parts, Periostracum Cicadae 15 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, the Radix Astragali 12 parts, 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 15 parts, the Radix Paeoniae Alba 15 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
S1: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40% is the alcoholic solution of 80%, and regulation and control carbon dioxide flow is 15L/h, and extracting pressure is 18MPa, extraction temperature is 60 DEG C, extraction time is 2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2: take Herba Schizonepetae, Cortex Dictamni, Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, add the water soaking of medical material gross weight 8 times amount after 12 hours, decoct 4 hours, filter, filtering residue adds 80% alcoholic solution of filtering residue gross weight 6 times amount, decoct 2 hours, filter, merge twice filtrate;
S3: the filtrate mixing that described Radix Ophiopogonis extract and S2 are obtained, being concentrated into relative density at 60 DEG C is the Chinese medical concrete of 1.20, drying under reduced pressure, crosses 100 mesh sieves, obtains Chinese medicine composition of the present invention;
S4: get sodium carboxymethyl cellulose and be placed in mortar, adds glycerol and grinds well, and then grinds while add the alcoholic solution of ethyl hydroxybenzoate, grinds well after swelling, and the Chinese medicine composition that S3 is obtained adds, and grinds well, obtains the ointment of Chinese medicine composition of the present invention.
test example one: Chinese medicine composition of the present invention is to the development test of ear eczema mice.
Experimental animal: provide cleaning grade kunming mice 40 by certain Bioisystech Co., Ltd, body weight 20g ± 3g, male and female half and half, be divided into 4 groups at random, often organizes 10.
Ear eczema Establishment of mouse model: first day is in two-sided dinitrochlorobenzene (DNCB) the solution sensitization of smearing 40 μ L5% of mice ears, within 4th day, smear the DNCB solution of 40 μ L1%, once smeared once every four days afterwards, totally 5 times, set up ear eczema mouse model.
Dosage regimen:
A group: get the Chinese medicine composition gelata of the present invention that the embodiment of the present invention 1 is obtained; Smear DNCB excites rear 24h, 48h, 72h to be coated with trial drug outward inside mice ears at every turn, and 1g/ is each, 2 times/day.
B group: get the Chinese medicine composition ointment of the present invention that the embodiment of the present invention 3 is obtained, dosage regimen is with A group.
Positive controls: get Compound Dexamethasone Cream (the accurate word H44024298 of traditional Chinese medicines), dosage regimen is with A group.
Model control group: the gel getting not drug containing in the embodiment of the present invention 1, dosage regimen is with A group.
Carry out the score of skin lesion degree by following standard: the obvious redness of ears thickens and oozes out, or obviously keratinization incrustation person remembers 3 points; Mild redness, oozes out not obvious, or moderate keratinization person is designated as 2 points; Red and swollen and ooze out all not obvious person, or slight keratinization person is designated as 1 point; Normal skin is 0 point.
Use spiral micrometer to measure ear swelling thickness respectively simultaneously.
Note: compare with model control group,
* p0.05;
* p0.01.
Drug test group of the present invention is compared with model control group, and mouse ear skin lesion integration and ear swelling thickness all have significant difference.Test data shows, drug test group mice is compared with model control group mice, and ear's skin lesion is clearly better, and ear swelling degree obviously reduces, simultaneously the curative effect of drug test group of the present invention and the therapeutic equivalence of positive controls.Result of the test shows, traditional Chinese medicine composition for treating of the present invention and prevention eczema successful, can be used for clinical expansion.
test two: the clinical trial of Chinese medicine composition of the present invention
One, diagnostic criteria
Draft with reference to the content of " diagnosis basis of eczema " in " Chinese medical disease Standardization of diagnosis and curative effect ".Diagnostic criteria is:
1, acute eczema
1) skin lesion is pleomorphism, as flushing, pimple, vesicle, erosion, ooze out, crust, desquamation, constant kind form exists simultaneously.
2) onset is anxious, conscious scorching hot, violent pruritus.
3) skin lesion is often symmetrical, common with places such as head, face, distal limbs, scrotum.Can general whole body.
4) subacute or chronic eczema can be developed into, time light time heavy, repeatedly do not heal.
2, subacute eczema: skin lesion oozes out less, based on pimple, papulovesicle, incrustation, squama.Have slight rotten to the corn face, color is more dark red.Also visible mild infiltration, violent pruritus.
3, chronic eczema: many limits office is in a certain position, and boundary is clear, have significantly plump infiltration, rough surface, or become in lichen sample, the brown red or brown of color, often with papulovesicle, crust, scratch.Be inclined to moistening change, normal recurrent exerbation, time light time heavy, have paroxysmal pruritus.
Two, clinical trial protocol
1. subjects basic document
The present invention collect clinical eczema volunteer 100 example, man 48 example, female 52 example, age 16-40 year, all experimenters are divided at random 2 groups, often organize 50,2 group case in sex, age, the course of disease etc. through statistical analysis, there is comparability.
2. trial drug and test method
Treatment group: ointment prepared by the embodiment of the present invention 3, often prop up ointment and contain medicine 12.5g, spread upon eczema place, every day, secondary, smeared 10 days continuously.
Positive controls: smear Compound Dexamethasone Cream (Baiyunshan Hejigong Medicine Factory of Guangzhou Baiyunshan Pharmaceutical Co., Ltd., the accurate word H44024298 of traditional Chinese medicines), twice daily, smear 10 days continuously.
3. criterion of therapeutical effect
Effective: eczema erythema obviously reduces, attack times reduces.
Invalid: compare with before treatment, symptom does not disappear or increases the weight of on the contrary.
Recurrence: cure latter 3 months and run into warm and still show effect.
4. therapeutic outcome, as shown in table 2.
Result of the test shows, the effect for the treatment of group traditional Chinese medicine composition for treating eczema of the present invention is better than positive control drug Compound Dexamethasone Cream.Treatment group is compared with positive controls, the total effective rate for the treatment of group is 84% higher than the total effective rate 70% of positive controls, and the recurrence number of cases for the treatment of group is significantly lower than the recurrence number of cases of positive controls, clinical observation, treatment group patient has no any untoward reaction at therapeutic process.Traditional Chinese medicine composition for treating eczema of the present invention is rapid-action, and safety is high, and relapse rate is low, and clinical generalization value is high.
Claims (6)
1. treat the Chinese medicine composition of eczema for one kind, it is characterized in that, described Chinese medicine composition is made primarily of the raw materials of following weight portion: Radix Ophiopogonis 15-30 part, Herba Schizonepetae 10-25 part, Cortex Dictamni 10-20 part, Periostracum Cicadae 10-25 part, Radix Arnebiae (Radix Lithospermi) 15-25 part, Radix Astragali 10-15 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5-20 part, Caulis Polygoni Multiflori 10-20 part, Radix Paeoniae Alba 10-18 part and Radix Glycyrrhizae 5-15 part.
2. the Chinese medicine composition for the treatment of eczema according to claim 1, it is characterized in that, described Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 15 parts, Herba Schizonepetae 10 parts, Cortex Dictamni 10 parts, Periostracum Cicadae 10 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, the Radix Astragali 10 parts, 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 10 parts, the Radix Paeoniae Alba 10 parts and 5 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of eczema according to claim 1, it is characterized in that, described Chinese medicine composition is made primarily of the raw materials of following parts by weight: Radix Ophiopogonis 30 parts, Herba Schizonepetae 25 parts, Cortex Dictamni 20 parts, Periostracum Cicadae 25 parts, Radix Arnebiae (Radix Lithospermi) 25 parts, the Radix Astragali 15 parts, 20 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 20 parts, the Radix Paeoniae Alba 18 parts and 15 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of eczema according to claim 1, is characterized in that, described Chinese medicine composition is made primarily of the raw materials of following parts by weight:
Radix Ophiopogonis 20 parts, Herba Schizonepetae 15 parts, Cortex Dictamni 15 parts, Periostracum Cicadae 15 parts, Radix Arnebiae (Radix Lithospermi) 20 parts, the Radix Astragali 12 parts, 5 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori 15 parts, the Radix Paeoniae Alba 15 parts and 10 parts, Radix Glycyrrhizae.
5., according to the Chinese medicine composition of the arbitrary described treatment eczema of claim 1-4, it is characterized in that, described Chinese medicine composition is made into paste, gel, ointment, ointment or liniment.
6., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment eczema of claim 1-4, it is characterized in that, comprise following steps:
S1: take Radix Ophiopogonis, be ground into coarse powder, be placed in supercritical carbon dioxide extraction apparatus, the volume fraction adding coarse powder weight 40-50% is the alcoholic solution of 60-85%, and regulation and control carbon dioxide flow is 15-20L/h, and extracting pressure is 15-20MPa, extraction temperature is 40-60 DEG C, extraction time is 1.5-2h, and decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
S2: take Herba Schizonepetae, Cortex Dictamni, Periostracum Cicadae, Radix Arnebiae (Radix Lithospermi), the Radix Astragali, Cortex cinnamomi japonici (Ramulus Cinnamomi), Caulis Polygoni Multiflori, the Radix Paeoniae Alba and Radix Glycyrrhizae, add residue described Radix Ophiopogonis, pulverize, after adding water soaking 12-24 hour of medical material gross weight 5-10 times amount, decoct 2-6 hour, filter, filtering residue adds the 50-80% alcoholic solution of filtering residue gross weight 2-6 times amount, decoct 1-3 hour, filter, merge twice filtrate;
S3: the filtrate mixing described Radix Ophiopogonis extract and S2 obtained, being concentrated into relative density at 50-60 DEG C is the Chinese medical concrete of 1.20-1.35, drying under reduced pressure, crosses 100-200 mesh sieve, obtains Chinese medicine composition of the present invention.
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| CN101167811A (en) * | 2007-10-25 | 2008-04-30 | 成都芝芝药业有限公司 | External-applied preparation with anti-inflammation, itching-relieving and sterilization function and manufacturing method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167811A (en) * | 2007-10-25 | 2008-04-30 | 成都芝芝药业有限公司 | External-applied preparation with anti-inflammation, itching-relieving and sterilization function and manufacturing method and application thereof |
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