CN104083469B - A kind of Chinese medicine being used for the treatment of Senile Functional Constipation - Google Patents
A kind of Chinese medicine being used for the treatment of Senile Functional Constipation Download PDFInfo
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- CN104083469B CN104083469B CN201410282945.7A CN201410282945A CN104083469B CN 104083469 B CN104083469 B CN 104083469B CN 201410282945 A CN201410282945 A CN 201410282945A CN 104083469 B CN104083469 B CN 104083469B
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Abstract
The present invention relates to a kind of Chinese medicine being used for the treatment of Senile Functional Constipation, it is prepared from by the raw medicinal material of following weight proportion: Cortex Albiziae 6 parts, Fructus Evodiae 3 parts, Flos Jasmini Sambac 6 parts, Rhodobryum roseum Limpr. 8 parts, Radix anthrisci 12 parts, Radix Astragali Preparata 15 parts, 3 parts, Radix Glycyrrhizae.Clinical trial certificate, the present invention can safe and effective treatment Senile Functional Constipation.
Description
Technical field
The present invention relates to a kind of Chinese medicine, be specifically related to a kind of Chinese medicine being used for the treatment of Senile Functional Constipation.
Background technology
Functional constipation is a kind of common disease, along with China economic level improve, the change of dietary structure, the impact of spirit and social factor in addition, constipation patient quantity presents ascendant trend, is many especially with senile constipation patient.Studies have reported that, the sickness rate of northern China Senile Functional Constipation is 14.6%, and increases with the growth at age.Primary disease has the features such as sickness rate is high, patient suffering's property large, general Chinese and western drugs therapeutic effect difference.Some relieving constipation medicines of long-term taking may cause melanosis coli and secondary constipation, deal with improperly and also can cause many serious clinical complications, as defecation too firmly can bring out apoplexy in hyperpietic, bring out in patients with coronary heart disease or increase the weight of myocardial infarction etc.
Medical material present Research involved in the present invention is as follows:
The Radix Angelicae Dahuricae [source] this product is the dry root of umbellate form section plant Radix Angelicae Dahuricae Angelicadahurica (Fisch.exHoffm.) Benth.etHook.f. or Radix angelicae dahuricae Angelicadahurica (Fisch.exHoffm.) Benth.etHook.f.var.formosana (Boiss.) ShanetYuan.Excavate when between summer, autumn, leaf is yellow, removing fibrous root and silt, dry or cold drying.[process of preparing Chinese medicine] removing impurity, separately size, slightly leaching, runs through, cuts sheet, dry.[nature and flavor] are pungent, temperature.[return through] returns stomach, large intestine, lung meridian.[function cures mainly] loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.[usage and dosage] 3 ~ 9g.
Fructus Jujubae [source] this product is the dry mature fruit of Rhamnaceae jujube Fructus Jujubae ZiziphusjujubaMill.var.inermis (Bunge) Rehd..Gather during fruit maturation in autumn, dry.Its root, bark are also used as medicine, and can adopt at any time.[process of preparing Chinese medicine] removing impurity, cleans, dries.Used time breaks or enucleation.[nature and flavor] are sweet, temperature.[return through] returns spleen, stomach warp.[function cures mainly] be (Fructus Jujubae) really: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.[usage and dosage] 6 ~ 15g.
Semen Cassiae [another name] Horse hoof Semen Cassiae, blunt leaf Semen Cassiae, false Semen phaseoli radiati, Semen Cassiae [source] this product are the dry mature seed of leguminous plant Semen Cassiae CassiaobtusifoliaL. or little Semen Cassiae CassiatoraL..To gather autumn mature fruit, dry, lay seed, removing impurity.[process of preparing Chinese medicine] Semen Cassiae: removing impurity, cleaning, drying.Used time smashs to pieces.Semen Cassiae (parched): get clean Semen Cassiae, fries according to method of frying and has fragrance to micro-.Used time smashs to pieces.[nature and flavor] are sweet, bitter, salty, are slightly cold.[return through] returns liver, large intestine channel.[function cures mainly] clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.[usage and dosage] 9 ~ 15g.
Rhodobryum roseum Limpr. [another name] Rhodobryum giganteum, fennel firewood grass, ferrum foot Rhizoma Arisaematis, Rhodobryum giganteum(Hook.) Par. [source] moss Bryaceae rhodobryum spp plant warm ground great Ye moss Rhodobryumgiganteum (Schwaegr.) Par., with all herbal medicine.The whole year can adopt, using fresh herb or dry in the shade.[nature and flavor] are pungent, bitter, flat.[function cures mainly] tranquilizing by nourishing the heart, liver heat removing and eyesight improving.For severe palpitation, neurasthenia; Conjunctival congestion and swelling pain is controlled in external.[usage and dosage] 1 ~ 3 money; Suitable amount used externally, decocts water smoking and washes.
Radix anthrisci [source] Umbelliferae Anthriscus plant Radix anthrisci Anthriscussylvestris (L.) Hoffm., is used as medicine with root, leaf.Uproot when 8 ~ JIUYUE aerial parts turns yellow, clean and boil, go crust to dry or dry; Leaf using fresh herb or dry levigation.[nature and flavor] sweet, pungent, micro-hardship, tepor.[function cures mainly] invigorating the spleen and replenishing QI, promoting tissue regeneration by removing blood stasis.Root: for traumatic injury, lumbago, cough due to deficiency of the lung, cough spitting of blood, splenasthenic abdominal distention, myasthenia of limbs, senile frequent micturition, edema; Leaf: wound [usage and dosage] root 4 ~ 5 money is controlled in external; Leaf suitable amount used externally, fresh leaf is mashed or cured leaf levigation applies affected part [extracts] " national Chinese herbal medicine compilation ".
Radix Astragali Preparata [source] this product is the Preparation process product of the Radix Astragali.[character] this product is circular or oval sheet, diameter 0.8 ~ 3.5cm, thick 0.1 ~ 0.4cm.The shallow pale brown or sepia of exocuticle, slightly gloss, visible vertical wrinkle or longitudinal furrow.Tangent plane skin zone is light yellow, and xylem is yellow, has radial texture and crack, and some centers are even dry and decayed shape, pitchy or in cavity.Tool honey fragrance, taste is sweet, slightly stickiness, and that chews micro-ly has beany flavor.[process of preparing Chinese medicine] gets astragalus mongholicus tablet, fries to tack-free according to processed with honey method (annex IID).[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.The invigorating middle warmer of [function cures mainly] QI invigorating.Weak for the deficiency of vital energy, anorexia and loose stool.[usage and dosage] 9 ~ 30g.
Radix Glycyrrhizae [source] this product is the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL..Spring, Qiu Erji excavate, and removing fibrous root, dries.[process of preparing Chinese medicine] removing impurity, cleans, runs through, cut sheet, dry.[nature and flavor] are sweet, flat.[return through] GUIXIN, lung, spleen, stomach warp.[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.[usage and dosage] 1.5 ~ 9g.[attention] should not with Radix Euphorbiae Pekinensis, Flos Genkwa, Radix Kansui with using.[storage] puts aeration-drying place, mothproof.[extracts] " Chinese Pharmacopoeia ".
Summary of the invention
The present invention aims to provide a kind of Chinese medicine being used for the treatment of Senile Functional Constipation, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing Senile Functional Constipation.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a Chinese medicine for Senile Functional Constipation, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: the Radix Angelicae Dahuricae 6 parts, 12 parts, Fructus Jujubae, Semen Cassiae 12 parts, Rhodobryum roseum Limpr. 8 parts, Radix anthrisci 9 parts, Radix Astragali Preparata 9 parts, 3 parts, Radix Glycyrrhizae.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor in JIUYUE, 2010 ~ 2013 collect outpatient service constipation patient 100 example altogether between year April, be divided into two groups at random, often organize 50 examples.Man 26 example in matched group, female 34 example; 60 ~ 81 years old age, average 73.5 years old; The course of disease 6 years ~ 21 years, average 9.1 years.Man 29 example in treatment group, female 31 example; 60 ~ 83 years old age, average 72.8 years old; 5-year courses ~ 16 year, average 8.9 years.Two groups of cases through statistical analysis no significant difference, have comparability in sex, age, the course of disease etc.
Tcm diagnosis standard: stagnation of QI dryness of the intestine is demonstrate,proved: primary symptom: 1. constipation with dry stool; 2. defecate not smooth, must not for solution.Secondary disease: 1. abdomen is done swollen less; 2. belch is done frequently; 3. the vexed distending pain of flank painful abdominal mass; 4. tongue is white; 5. thready and stringy pulse.Primary symptom 1 adds time disease 1 and adds tongue arteries and veins diagnosable disease.
Exclusion standard
Constipation-predominant of irritable bowel syndrome, the chronic constipation person that merging digestive tract tumor, incretion metabolism disease, connective tissue disease, nervous system disease cause, severe constipation person; There is serious complications, as megacolon, enteroparalysis, intestinal perforation, intestinal obstruction person; There are canceration person in colonoscopy and histopathologic examination; With mental sickness, serious neurological impaired person, as aphasia, agnosia patient, suspects or truly has ethanol, drug dependence history person; Merge the systemic disease persons such as severe cardiac, liver, lung, kidney, blood; Current concurrent infection disease, as acute and chronic respiratory disease patient; According to the judgement of researcher, have and reduce into group probability or make into other complicated pathological changes of group.
2, test method
2.1 Therapeutic Method
The decoct that the oral the present invention of test group obtains according to specific embodiment 1, every day 3 times.4 weeks courses for the treatment of.
The oral Tongbianling Capsules of matched group, one time 5 ~ 6,1 time on the one.
Two groups of period in a medicine are avoided eating anything raw or cold, pungent greasy thing.
3, criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
Cure: cardinal symptom disappears, defecation 1 time within 2d, and just matter turns profit, unobstructed during solution, nothing recurrence in 6 months after drug withdrawal;
Take a turn for the better: defecation within 3d, just matter turns profit, and defecation owes smooth;
Invalid: symptom is without improvement.
3.2 therapeutic outcomes are in table 1
Table 1 liang group clinical efficacy results contrast
| Group | n | Cure | Take a turn for the better | Invalid | Total effective rate (%) | Untoward reaction example |
| Treatment group | 50 | 26 | 22 | 2 | 96％ | 0 |
| Matched group | 50 | 0 | 40 | 10 | 80％ | 0 |
Result is visible, and Chinese medicine of the present invention can the safe and effective treatment for Senile Functional Constipation.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Specific embodiment 1
Take: the Radix Angelicae Dahuricae 6 grams, 12 grams, Fructus Jujubae, Semen Cassiae 12 grams, Rhodobryum roseum Limpr. 8 grams, Radix anthrisci 9 grams, Radix Astragali Preparata 9 grams, 3 grams, Radix Glycyrrhizae; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of Senile Functional Constipation.Oral, every bu morning, noon and afternoon take for three times.
Specific embodiment 2
Take: the Radix Angelicae Dahuricae 6 grams, 12 grams, Fructus Jujubae, Semen Cassiae 12 grams, Rhodobryum roseum Limpr. 8 grams, Radix anthrisci 9 grams, Radix Astragali Preparata 9 grams, 3 grams, Radix Glycyrrhizae; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of Senile Functional Constipation.Oral, every bu is taken for twice sooner or later.
Specific embodiment 3
Take: the Radix Angelicae Dahuricae 6 grams, 12 grams, Fructus Jujubae, Semen Cassiae 12 grams, Rhodobryum roseum Limpr. 8 grams, Radix anthrisci 9 grams, Radix Astragali Preparata 9 grams, 3 grams, Radix Glycyrrhizae; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, then adds appropriate dextrin and correctives, granulates according to this area common process, and packaging, can obtain the granule meeting adult normal's one day consumption.
Be used for the treatment of Senile Functional Constipation.Oral, daily once.
Claims (3)
1. be used for the treatment of a Chinese medicine for Senile Functional Constipation, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: the Radix Angelicae Dahuricae 6 parts, 12 parts, Fructus Jujubae, Semen Cassiae 12 parts, Rhodobryum roseum Limpr. 8 parts, Radix anthrisci 9 parts, Radix Astragali Preparata 9 parts, 3 parts, Radix Glycyrrhizae.
2. a kind of Chinese medicine being used for the treatment of Senile Functional Constipation as claimed in claim 1, it is characterized in that, its preparation method is: take: the Radix Angelicae Dahuricae 6 parts, 12 parts, Fructus Jujubae, Semen Cassiae 12 parts, Rhodobryum roseum Limpr. 8 parts, Radix anthrisci 9 parts, Radix Astragali Preparata 9 parts, 3 parts, Radix Glycyrrhizae; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 parts, obtains decoct; Above-mentioned part all refers to weight portion.
3. a kind of Chinese medicine being used for the treatment of Senile Functional Constipation as claimed in claim 1, it is characterized in that, its preparation method is: take: the Radix Angelicae Dahuricae 6 parts, 12 parts, Fructus Jujubae, Semen Cassiae 12 parts, Rhodobryum roseum Limpr. 8 parts, Radix anthrisci 9 parts, Radix Astragali Preparata 9 parts, 3 parts, Radix Glycyrrhizae; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, obtains powder; Above-mentioned part all refers to weight portion.
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Inventor after: Shen Xian Inventor before: Liu Haiqiang |
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Effective date of registration: 20160215 Address after: 325002, No. 63, 9 Nong Tian Road, Hong Dian street, Lucheng District, Zhejiang, Wenzhou, China Applicant after: Shen Xian Address before: Quangang District of Quanzhou City, Fujian province 362803 after long Zhen Hou Qi Cun Mei Lin No. 145 Applicant before: Liu Haiqiang |
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