CN101732648B - Medicament for treating nonunion - Google Patents
Medicament for treating nonunion Download PDFInfo
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- CN101732648B CN101732648B CN2010100114201A CN201010011420A CN101732648B CN 101732648 B CN101732648 B CN 101732648B CN 2010100114201 A CN2010100114201 A CN 2010100114201A CN 201010011420 A CN201010011420 A CN 201010011420A CN 101732648 B CN101732648 B CN 101732648B
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Abstract
The invention discloses a medicament for treating nonunion for treating nonunion, which is prepared from sargentgloryvine stem, beautiful sweetgum fruit, diverse wormwood herb, malaytea scurfpea fruit, fortune's drynaria rhizome, south dodder seed, east asian tree fern rhizome, dipsacus root, sharpleaf galangal fruit, clematis root and sappan wood in certain proportion by weight. The medicament has the characteristics of tonifying the kidney and setting bones, detoxifying and removing obstruction in channels, promoting the growth of osteotylus quickly, promoting cataclasis union and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, especially a kind of medicine that is used to treat bone does not connect.
Background technology
Along with the development of society, the vehicle accident incidence rate rises year by year, and the fracture traumatic patient that therefore causes is more and more, the state of an illness is tending towards complicated, disability rate and rises year by year, has brought the huge social economic pressures to the patient.At present, various " showy reiolaena root-barks " occur frequently not poor, but often have problems such as therapeutic effect is not obvious even invalid, side effect is big, make patient's the state of an illness can not get alleviating, and then have brought huge financial burden and social mentality's pressure to patient and family members.
Summary of the invention
Technical assignment of the present invention is that a kind of Chinese medicine preparation that can accelerating bone healing is provided to above existing issue, and said preparation has the kidney tonifying symplectic bone, and dispelling toxins and dredging collaterals promotes growth of spur rapidly, promotes characteristics such as union of fracture.
In order to solve the problems of the technologies described above; Solution of the present invention is according to understanding and the Therapeutic Principle of China's Chinese materia medica to fracture mechanism, from medicine, filters out the kidney tonifying symplectic bone, dispelling toxins and dredging collaterals; Natural Chinese medicines such as blood circulation promoting and blood stasis dispelling; By the theory of Chinese medical science prescription, that processes a kind ofly has the callus of promotion and generates the medicine of accelerating bone healing effect.
Medicine of the present invention is (consumption is weight part ratio) of being processed by the raw material of following component
Caulis Sargentodoxae 15-40 part Fructus Liquidambaris 15-40 part Herba Artemisiae Anomalae 6-20 part
Fructus Psoraleae 10-25 part Rhizoma Drynariae 10-25 part Semen Cuscutae 6-20 part
Rhizoma Cibotii 6-20 part Radix Dipsaci 10-25 part Fructus Alpiniae Oxyphyllae 6-20 part
Radix Clematidis 6-20 part Lignum Sappan 6-20 part
Medicine preferred weight proportioning of the present invention is:
Caulis Sargentodoxae 20-35 part Fructus Liquidambaris 20-35 part Herba Artemisiae Anomalae 10-17 part
Fructus Psoraleae 13-20 part Rhizoma Drynariae 13-20 part Semen Cuscutae 10-17 part
Rhizoma Cibotii 10-17 part Radix Dipsaci 13-20 part Fructus Alpiniae Oxyphyllae 10-17 part
Radix Clematidis 10-17 part Lignum Sappan 10-17 part
The best proportioning of medicine of the present invention is:
12 parts of 30 parts of Herba Artemisiae Anomalaes of 30 parts of Fructus Liquidambaris of Caulis Sargentodoxae
15 parts of 15 parts of Semen Cuscutae of 15 parts of Rhizoma Drynariae of Fructus Psoraleae
12 parts of 15 parts of Fructus Alpiniae Oxyphyllae of 15 parts of Radix Dipsaci of Rhizoma Cibotii
12 parts of 12 portions of Lignum Sappans of Radix Clematidis
Medicament selection Caulis Sargentodoxae of the present invention, Fructus Liquidambaris, Herba Artemisiae Anomalae, Fructus Psoraleae, Rhizoma Drynariae, Semen Cuscutae, Rhizoma Cibotii, Radix Dipsaci, Fructus Alpiniae Oxyphyllae, Radix Clematidis and Lignum Sappan make up; Make each efficacy of drugs produce synergism these drug regimens; Thereby effectively promote callus to generate; Accelerating bone healing, wherein: Caulis Sargentodoxae: be Sargentodoxaceae fallen leaves bejuco Caulis Sargentodoxae SargentooxaCu-neataRehdetWils ratan; Nature and flavor: flat, return large intestine channel, have heat-clearing and toxic substances removing, the effect of promoting blood circulation to remove blood stasis analgesic.
Fructus Liquidambaris: these article are the drying and ripening infructescence of Hamamelidaceae plant Chinese sweet gum Liquidambar formosana Hance; Nature and flavor are bitter, and are flat.Return liver, kidney channel.Effect with promoting blood circulation to remove obstruction in the collateral
Herba Artemisiae Anomalae: be the herb of feverfew artemisia anomalas.The bitter temperature of nature and flavor, the GUIXIN spleen channel.Have removing blood stasis and stimulate the menstrual flow, the effect of eliminating stasis to stop pain.
Fructus Psoraleae: be the fruit of legumes psoraleae.Acrid in the mouth; Bitter; Warm in nature.Return the kidney spleen channel, have invigorating kidney-YANG, the effect of warming the spleen kidney.
Rhizoma Drynariae: these article are the dry rhizome of Polypodiaceae plant Mongolian oak Herba pteridii latiusculi Drynaria fortunei (Kunze) J.Sm..Nature and flavor are bitter, temperature.Go into liver, kidney channel.Has invigorating kidney, promoting blood circulation, the effect of the continuous muscle of pain relieving.
Semen Cuscutae: be the seed of convolvulus cuscuta plant Cuscuta chinessis Lam..The property acrid-sweet flavor flat.Return the Liver and kidney warp, have the kidney-replenishing of being, tonifying kidney-yin again, the effect of YANG invigorating tonifying YIN.
Rhizoma Cibotii: these article are the dry rhizome of Dicksoniaceae plant Rhizoma Cibotii Cibotium barometz (L.) J.Sm..Nature and flavor are worked hard warm.Return the Liver and kidney warp, have invigorating the liver and kidney, strong waist knee joint, hard muscles and bones, the effect of the rheumatism of warmly loosing again.
Radix Dipsaci: be the root of Dipsacaceae plant Radix Dipsaci or Radix Dipsaci.The property bitter but sweet flavor hot.Return the Liver and kidney warp.Have reuniting the fractured tendons and bones, promoting the circulation of blood feeling pulse effect has detumescence, pain relieving, granulation promoting, effects such as symplectic bone.
Fructus Alpiniae Oxyphyllae: property and flavor of peppery and warm.Return spleen, kidney channel.Effect with warming the spleen the kidney invigorating.
Radix Clematidis: these article are the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala (mountain knotweed) Clematis hexapetala Pall. or northeast clematis (black common vetch) Clematis manshurica Rupr..The hot salty temperature of nature and flavor is returned urinary bladder channel, has wind-damp dispelling, the meridian dredging, the effect of pain relieving.This moral character is walked to scurry, the ability the meridian dredging, and wind-damp dispelling, analgesic effect is strong.
Lignum Sappan: be the dry duramen of Caesalpiniaceae Caesalpinia plant Lignum Sappan (Caesalpinia sappan L.).The property sweet-salty little suffering, flat.GUIXIN liver spleen channel.Has promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing.
The present invention adopts method for preparing of the prior art, as clean, baking, pulverizing, seepage, filtration, concentrate, drying, packing etc., can obtain required powder, pack then; Also can process capsule etc. by conventional method of the prior art.
Caulis Sargentodoxae has promoting blood circulation to remove blood stasis and analgesic effect in the present invention, is used for traumatic injury, arthralgia; The Fructus Liquidambaris promoting blood circulation to remove obstruction in the collateral makes QI-blood circulation unobstructed, " general rule is not bitterly "; It is logical that the Herba Artemisiae Anomalae hardship is let out temperature, is good at row and looses, and can stimulate the menstrual flow by removing blood stasis, and eliminating stasis to stop pain is used for folding and falls diseases such as damage and wound hemorrhage; The Fructus Psoraleae kidney invigorating and YANG supporting, warmly invigorating spleen yang; The Rhizoma Drynariae the kidney invigorating, invigorate blood circulation, continuous hinder, hemostasis, be used for the traumatic injury sprain and contusion, injuring both tendon and bone; Semen Cuscutae is kidney-replenishing both, again tonifying kidney-yin; The Rhizoma Cibotii invigorating the liver and kidney, strong waist knee joint, hard muscles and bones; Radix Dipsaci can invigorating the liver and kidney, again can the promoting the circulation of blood arteries and veins, and reuniting the fractured tendons and bones has the advantage of tonify without causing stagnation, and effects such as detumescence, pain relieving, granulation promoting are arranged again, is used for the traumatic injury fracture; Fructus Alpiniae Oxyphyllae warming the spleen warming the kidney is used for diseases such as spleen-kidney vacuity cold; Radix Clematidis property is apt to away scurry, the ability the meridian dredging, and analgesic effect is strong; The Lignum Sappan promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing is used for the treatment folding and falls stasis of blood pain.
The patient of bone does not connect is longer because of the back time of fracturing, disunion for a long time, and the QI and blood consumption is hindered bigger, caused by liver and kidney deficiency, stagnation of QI-blood, venation is obstructed, and muscles and bones cervical carcinoma with cachexia, prescription of the present invention are guidance with the theory of Chinese medical science, and outstanding kidney tonifying symplectic bone is aided with dispelling toxins and dredging collaterals, blood circulation promoting and blood stasis dispelling.The kidney generating marrow and dominating bone, kidney qi is sufficient, YIN and YANG balancing, the QI and blood bar reaches, and the strong marrow of bone is given birth to, and venation is unobstructed, and this is an important feature of the present invention.The present invention fills a prescription rationally, and utilizes the comprehensive function treatment bone does not connect of the Chinese medicine of respectively distinguishing the flavor of, and has the kidney tonifying symplectic bone; Dispelling toxins and dredging collaterals promotes growth of spur rapidly, promotes union of fracture; Make the patient reduce permanent disability and second operation, have good social benefit and economic benefit, and harmless to human non-toxic.
Medicine of the present invention can adopt the conventional method of oral medicinal herb dosage form to be prepared into the medication for oral administration of any routine.For example, get filtrating and be condensed into cream each component medicine decocte with water according to a certain ratio; Each component drug is ground the powder of processing add ethanol, starch etc., process granule or tabletting is processed tablet.Said method all belongs to protection scope of the present invention.
The specific embodiment
Embodiment one, 1, with Caulis Sargentodoxae 300 grams, Fructus Liquidambaris 300 grams, Herba Artemisiae Anomalae 120 grams, Fructus Psoraleae 150 grams, Rhizoma Drynariae 150 grams, Semen Cuscutae 150 grams, Rhizoma Cibotii 150 grams, Radix Dipsaci 150 grams, Fructus Alpiniae Oxyphyllae 120 grams, Radix Clematidis 120 grams and Lignum Sappan 120 grams; 11 flavor medicines grind jointly, process powder.
The powder decocte with water of 2, the said ratio medicine being ground is condensed into cream.
The medicine that 3, will be condensed into cream adds suitable amount of adhesive, like starch etc., processes pill of uniform size, and each pill weight is 6 grams.
Instructions of taking: adult consumption every day twice, sooner or later each once, 6g/ time, eliminating cold for resuscitation water send down, period in a medicine fasting raw food and irritable food, 15 days is a course of treatment, generally needs to cure 4-6 the course of treatment.
Embodiment two, 1, with Caulis Sargentodoxae 250 grams, Fructus Liquidambaris 250 grams, Herba Artemisiae Anomalae 110 grams, Fructus Psoraleae 140 grams, Rhizoma Drynariae 140 grams, Semen Cuscutae 110 grams, Rhizoma Cibotii 110 grams, Radix Dipsaci 140 grams, Fructus Alpiniae Oxyphyllae 110 grams, Radix Clematidis 110 grams and Lignum Sappan 110 grams; 11 flavor medicines grind jointly, process powder.
The powder decocte with water of 2, the said ratio medicine being ground is condensed into dry extract.
3, the dry extract that is prepared into is broken into fine powder, processes powder, every bag 6 grams.
Instructions of taking: adult consumption every day twice, sooner or later each once, 6g/ time, eliminating cold for resuscitation water send down, period in a medicine fasting raw food and irritable food, 15 days is a course of treatment, generally needs to cure 4-6 the course of treatment.
Below be the clinical observation on the therapeutic effect test that the present invention promotes union of fracture:
One, diagnostic criteria
1, tcm diagnosis standard
Pain appears in all traumatic injury later stages, swelling, and abnormal movement, limb activity is limited, palor or desquamation is arranged, amyotrophy, dizzy, soreness of waist and knee joint, the dimly pale tongue white and moist fur, or the red tongue tongue is few, and deep and weak pulse belongs to caused by liver and kidney deficiency card person.
2, Western medicine diagnose standard
1. fracture end has abnormal movement, and the time was above 8 months; 2. bear a heavy burden bitterly the heavy burden afunction; 3. symptom: pain and tenderness, local swelling, dysfunction, deformity and amyotrophy, abnormal movement, bony crepitus; 4. the X ray examination shows: fracture end is gapped, the fracture end sclerosis, and the pulp cavity sealing, osteoporosis, no bone trabecula forms between callus; 5. fracture and injury type: horizontal shape, oblique, comminuted, spiral type etc.; 6. fracture and injury position: upper limb, lower limb, tibia, radius etc.; 7. fracture and injury degree: displacement, overlapping, separation etc.
Two, include the case standard in
1, test case choice criteria: 1. meet Chinese medical discrimination standard and Western medicine diagnose standard; 2. age: 18～65 years old; 3. the bone does not connect time is between 6-18 month.
2, get rid of the case standard: 1. by the pathologisch Bruch due to the factors such as tumor; 2. three spend open fractures, concurrent infection property fracture or serious visceral organ injury fracture; 3. gestation or women breast-feeding their children; 4. to this medicine allergy sufferers; 5. be associated with serious primary disease such as cardiovascular, lung, liver, kidney, brain, hemopoietic and hormonal system; 6. psychotic; 7. take and cure mainly akin medicine with this medicine function and the bone does not connect influential medicine that heals; 8. all standards of including in that do not meet by the regulation medication, can't not judged the not congruent person of affecting the treatment of curative effect or data.
Accept clinical fracture patient 87 examples for medical treatment according to the above-mentioned case standard of including in, the age all between 18～65 years old, male 51 examples, women 36 examples, M-F is 1.42/1; Position difference according to bone does not connect is divided into: tibia 45 examples, femur 23 examples, humerus 7 examples, clavicle 3 examples, chi radius 9 examples.9～18 months above-mentioned patient's bone does not connect time, average 12 months.
Three, Therapeutic Method
1, meet the 87 routine patients that case requires and be divided into two groups above-mentioned: treatment group and matched group according to the age size, are divided into three groups, the concrete grouping as follows in every group:
(unit: year, people)
| Group name the age | 18-30 | 31-50 | 51-65 |
| The treatment group | 16 | 14 | 14 |
| Matched group | 16 | 14 | 13 |
2, be medicine with embodiment one products obtained therefrom, treatment group patient takes medicine pill of the present invention every day sooner or later respectively once, and 6g/ time, eliminating cold for resuscitation water send down, period in a medicine fasting raw food and irritable food.
3, matched group patient applying clinical conventional medicine is treated, and does not use medicine of the present invention.
4, the course of treatment: 15 days is a course of treatment, looks the bone does not connect position and observes 2-3 the course of treatment.
Four, therapeutic outcome
1, observation of curative effect: 1. bone does not connect healing state; 2. limb activity situation; 3. callus formation situation.
2, efficacy assessment standard
Produce effects: sx, limb activity can, X-ray film shows that fracture line is fuzzy, a large amount of callus formation, even few patients has bone trabecula to form.
Effectively: sx, but limbs light activity, X-ray film show that fracture line is fuzzy or a small amount of callus formation are arranged.
Invalid: symptom does not see and alleviates that limb activity is poor, and X-ray film shows that fracture line exists, and does not see obvious callus formation.
3, therapeutic outcome (seeing table 1 to table 3)
The therapeutic evaluation result (example) of table 1 treatment group
| Curative effect age cohorts | 18-30 (year) | 31-50 (year) | 51-65 (year) |
| Produce effects | 14 | 12 | 9 |
| Effectively | 2 | 1 | 4 |
| Invalid | 0 | 1 | 1 |
The therapeutic evaluation result (example) of table 2 matched group
| Curative effect age cohorts | 18-30 (year) | 31-50 (year) | 51-65 (year) |
| Produce effects | 9 | 5 | 2 |
| Effectively | 5 | 4 | 4 |
| Invalid | 2 | 5 | 7 |
After finish two courses of treatment, the treatment group case of taking medicine of the present invention, effective percentage reaches 95.5%, and uses the matched group of conventional treatments, and effective percentage is merely 67.4%, two group of comparison therapeutic effect has significant differences (P＜0.01); Therefore some patient that fails to respond to any medical treatment has influenced therapeutic effect because older, bone does not connect time is long or correctly do not take medicine of the present invention on request.
The comparison (example) of table 3 x line growth of spur situation
See that table 2:x line shows that the growth of spur situation has a small amount of callus formation for (+) expression, bone density is light; The x line shows that the growth of spur situation has more callus formation for (++) expression, and bone density is slightly high; The x line shows that the growth of spur situation forms for (+++) expression callus in a large number, and fracture line is fuzzy, and fracture is about to healing; The x line shows that the growth of spur situation forms for (++ ++) expression callus in a large number, and fracture line disappears, union of fracture.
According to above-mentioned standard judge bone does not connect after 60 days treatment group case bone does not connect healing rate be 91%, the effective percentage of Drug therapy bone does not connect promptly of the present invention is 91%; The effective percentage of The control group conventional treatments treatment bone does not connect is merely 56%.
Histopathology shows that treatment group patient's osseous tissue mainly is made up of normal tabular bone, and its blood capillary is abundant, arrangement of collagen fibers rule, elongated; The osteocyte form is normal, and cell volume is little, quantity is few, forms complete havers' system, returns to normal organizational structure basically.Matched group patient's osseous tissue then still is in the active proliferation stage; The visible part bone that interweaves in the tabular bone, collagen fiber are thick, short, it is irregular to arrange; The osteocyte number is many, and volume is big, and sees outgrowth osteoblast.The result shows that treatment group curative effect obviously is superior to matched group.Period in a medicine, treatment group patient does not find untoward reaction.
Claims (1)
1. medicine of treating bone does not connect is characterized in that this medicine is to be processed by the raw material of following weight portion:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100114201A CN101732648B (en) | 2010-01-04 | 2010-01-04 | Medicament for treating nonunion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010100114201A CN101732648B (en) | 2010-01-04 | 2010-01-04 | Medicament for treating nonunion |
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| Publication Number | Publication Date |
|---|---|
| CN101732648A CN101732648A (en) | 2010-06-16 |
| CN101732648B true CN101732648B (en) | 2012-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010100114201A Expired - Fee Related CN101732648B (en) | 2010-01-04 | 2010-01-04 | Medicament for treating nonunion |
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| CN103263543B (en) * | 2013-05-27 | 2014-07-09 | 青岛市市立医院 | Nursing liquid for postoperative fumigation treatment of fracture patient |
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Granted publication date: 20120125 Termination date: 20130104 |