CN102631649B - Method for preparing traditional Chinese medicine (TCM) for treating kidney-Yang deficiency type colitis - Google Patents

Method for preparing traditional Chinese medicine (TCM) for treating kidney-Yang deficiency type colitis Download PDF

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CN102631649B
CN102631649B CN2012100954400A CN201210095440A CN102631649B CN 102631649 B CN102631649 B CN 102631649B CN 2012100954400 A CN2012100954400 A CN 2012100954400A CN 201210095440 A CN201210095440 A CN 201210095440A CN 102631649 B CN102631649 B CN 102631649B
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李勤
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Abstract

The invention provides a method for preparing a traditional Chinese medicine (TCM) for treating kidney-Yang deficiency type colitis, belonging to the technical field of TCM preparation methods. At present, amikacin is generally adopted to treat kidney-Yang deficiency type colitis and has the defect of big side effects. The method is characterized by comprising the following steps: preparing cordyceps sinensis, desertliving cistanche, actinolite, cortex eucommiae, fleeceflower root, flatstem milkvetch seed, malaytea scurfpea fruit, Chinese holy leaf, common fenugreek seed, walnut seeds, rhizoma drynariae, stalactite, lotus seeds, hippocampus japonicus, sea cucumber, callorhinus ursinus, mulberry, Chinese taxillus herb, China dodder, Chinese dates, Chinese yam, wheat, heterophylly falsestarwort root, black-bone chicken, wild cabbage, longan aril, largehead atractylodes rhizome, white paeony root, American ginseng, angelica, dangshen, sharpleaf galangal fruit, milkvetch root, manyflower solomonseal rhizome, polished round-grained rice, bird's nest, dried finger, glossy ganoderma and liquorice, soaking the above 39 Chinese medicinal materials into water and then decocting with slow fire, thus obtaining the decocted soup, namely the TCM for treating kidney-Yang deficiency type colitis. The method has the following advantages: the prepared liquid TCM has low toxic and side effect and high recovery rate; the course of treatment is short; and the monarch, minister, assistant and guide are matched perfectly.

Description

A kind of Chinese medicinal preparation method for the treatment of kidney-yang deficiency type colitis
Technical field
The present invention relates to the Chinese medicinal preparation method technical field, is a kind of Chinese medicinal preparation method for the treatment of kidney-yang deficiency type colitis more specifically.
Background technology
Treatment kidney-yang deficiency type colitis, generally employing at present: 1, amikacin: nephrotoxicity and ear toxication certainly exist.Idol has nauseating, vomiting, headache, heating, erythra, trembles, paraesthesia, arthralgia, eosinophilia, anemia and hypotension etc.2, norfloxacin: 1. gastrointestinal symptom is seen more; 2. erythra, leukopenia, the property a crossed transaminase raise; 3. there is report can influence the cartilage development of immaturity animal, so the careful usefulness of child.3, ribostamycin: accidental erythra, headache, numbness, transaminase's one property crossed rising and injection site pain.4, isepamicin: accidental erythra, pruritus, heating, numbness, tinnitus, weak, inappetence, leukopenia, eosinophilic granulocyte increase, transaminase one crosses property rising etc.5, ofloxacin: 1. gastrointestinal reaction is more common; 2. accidental headache, insomnia, liver function one are crossed and are sexually revised.6, gentamycin: 1. when therapeutic dose, this product is based on hearing impairment, but unsuitable a large amount of or prolonged application; 2. nephrotoxicity is stronger.7, micronomicin: 1. long-term or extensive application may cause the murder by poisoning of acoustic nerve and kidney; 2. allergy such as erythra can appear in a few patients, have allergies person to avoid usefulness to other aminoglycosides antibiotics; 3. renal function goes down and the careful usefulness of old people; 4. the careful usefulness of abnormal liver function and anemia of pregnant woman.8, kanamycin: this product is all toxic to acoustic nerve and kidney, the former shows as tinnitus, auditory dysesthesia even permanent deafness (because of based on the vestibule infringement, so relatively more serious), for this must highly vigilant of be appropriate to old people, anemia of pregnant woman's (can influence fetus); The latter shows as albuminuria, cylinderuria etc.
Summary of the invention
For overcoming above shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of kidney-yang deficiency type colitis.The cardinal symptom of kidney-yang deficiency type colitis is to have loose bowels, and has loose bowels to refer to that defecation frequency increases, and feces is thin, even gushes as water sample.The slow person of thin and gesture is for letting out with big loose stool for former worthies, and stool is rare clearly directly to descend the person for rushing down as water.Assertive evidence is called and lets out at " interior warp ", and " watery diarrhea " arranged, " watery diarrhea ", " lientery ", " watery diarrhea " etc.Difficult Classic has the branch of five kinds of diarrhea, and the Chinese Tang epoch are called " diarrhea ", general designation " having loose bowels " after the Song dynasty.
Etiology and pathogenesis: have loose bowels with the passing of time, kidney yang deficiency can not the replenishing vital QI with drugs of warm nature taste, dysfunction of the spleen in transportation and transformation, and hypofunction of YANG QI before dawn, more severe YIN-cold, and send out primary disease.
Clinical manifestation: before dawn, abdominal part is had a pain more than having loose bowels, and borborygmus are namely rushed down, then pacifies after rushing down, and coldness of the body with chills, waist knee joint flaccidity is soft, pale tongue with white fur, deep-thready pulse.
Its technical scheme is: get Cordyceps 9 weight portions, Herba Cistanches 6 weight portions, Actinolitum 3 weight portions, the Cortex Eucommiae 6 weight portions, Radix Polygoni Multiflori 9 weight portions, Semen Astragali Complanati 3 weight portions, Fructus Psoraleae 6 weight portions, Folium Ilicis Cornutae 9 weight portions, Semen Trigonellae 3 weight portions, semen juglandis 9 weight portions, Rhizoma Drynariae 6 weight portions, Stalactitum 3 weight portions, Semen Nelumbinis 9 weight portions, the hippocampus 3 weight portion, Stichopus japonicus 3 weight portions, Testis et penis callorhini 3 weight portions, Fructus Mori 9 weight portions, Herba Taxilli 3 weight portions, Semen Cuscutae 6 weight portions, Fructus Jujubae 9 weight portions, Rhizoma Dioscoreae 3 weight portions, Semen Tritici aestivi 9 weight portions, Radix Pseudostellariae 6 weight portions, Gallus Domesticus 6 weight portions, Caulis et Folium Brassicae capitatae 6 weight portions, Arillus Longan 3 weight portions, the Rhizoma Atractylodis Macrocephalae 6 weight portions, Radix Paeoniae Alba 6 weight portions, Radix Panacis Quinquefolii 6 weight portions, Radix Angelicae Sinensis 6 weight portions, Radix Codonopsis 6 weight portions, Fructus Alpiniae Oxyphyllae 3 weight portions, the Radix Astragali 3 weight portions, Rhizoma Polygonati 6 weight portions, Semen oryzae sativae 9 weight portions, Nidus collocaliae 9 weight portions, Rhizoma Zingiberis 3 weight portions, Ganoderma lucidum seu Japonicum 6 weight portions and Radix Glycyrrhizae 9 weight portions, above 39 flavor Chinese medicines are put into 1800 ml waters, soaked 30 minutes, slow fire is fried 30 minutes then, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine for the treatment of kidney-yang deficiency type colitis.
The advantage of this invention is: we's 39 flavor Chinese medicines, all can buy in pharmacy, and to make simply, the herb liquid toxic and side effects of making is little, short treating period, cure rate height.Monarch, just right.When using Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided the Western medicine antibacterials to cause.Cordyceps, Herba Cistanches, Actinolitum, the Cortex Eucommiae, Radix Polygoni Multiflori, Semen Astragali Complanati, Fructus Psoraleae, Folium Ilicis Cornutae, Semen Trigonellae, semen juglandis, Rhizoma Drynariae, Stalactitum, Semen Nelumbinis, Hippocampus, Stichopus japonicus, Testis et penis callorhini, Fructus Mori, Herba Taxilli, Semen Cuscutae, more than 19 flavor medical instruments useful kidney yangs, tonifying deficiency, reinforcing the kidney and supporting YANG, warming the kidney to invigorate YANG, strong muscles and bones, nourishing the liver and kidney, tonifying the kidney to consolidate the essence, tonifying liver makes eye bright, the effect of spleen reinforcing antidiarrheal.In the process for the treatment of kidney-yang deficiency type colitis, play main therapeutical effect, so be monarch drug.Fructus Jujubae, Rhizoma Dioscoreae, Semen Tritici aestivi, Radix Pseudostellariae, Gallus Domesticus, Caulis et Folium Brassicae capitatae, Arillus Longan, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, the Radix Astragali, Rhizoma Polygonati, Semen oryzae sativae, Nidus collocaliae, Rhizoma Zingiberis, more than 18 flavor medical instruments useful kidney and replenishing marrows, air making-up and spleen enlivening, the effect of diuretic detumescent.In the process for the treatment of kidney-yang deficiency type colitis, can assist principal agent performance therapeutical effect, so be ministerial drug.Ganoderma lucidum seu Japonicum: sweet, flat.Go into kidney, liver, the heart, lung four warps.Smart guarantor is refreshing for benefit, hard muscle profit face, and ear is filled in the kidney invigorating, eliminating impediment dispels the wind.The all medicines of the energy rate focus of going directly is so be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate the toxicity of all medicines again, so be messenger drug.Cordyceps, Herba Cistanches, Actinolitum, the Cortex Eucommiae, Radix Polygoni Multiflori, Semen Astragali Complanati, Fructus Psoraleae, Folium Ilicis Cornutae, Semen Trigonellae, semen juglandis, Rhizoma Drynariae, Stalactitum, Semen Nelumbinis, Hippocampus, Stichopus japonicus, Testis et penis callorhini, Fructus Mori, Herba Taxilli, Semen Cuscutae, Fructus Jujubae, Rhizoma Dioscoreae, Semen Tritici aestivi, Radix Pseudostellariae, Gallus Domesticus, Caulis et Folium Brassicae capitatae, Arillus Longan, the Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, Radix Panacis Quinquefolii, Radix Angelicae Sinensis, Semen Nelumbinis, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, the Radix Astragali, Rhizoma Polygonati, Semen oryzae sativae, Nidus collocaliae, Rhizoma Zingiberis, Ganoderma lucidum seu Japonicum, Radix Glycyrrhizae, this 39 flavor medicine compatibility is used, play tonifying deficiency jointly, reinforcing the kidney and supporting YANG, warming the kidney to invigorate YANG, strong muscles and bones, nourishing the liver and kidney, strengthening the spleen and nourishing the stomach, warm spleen cold expelling, smart god, the effect of hard muscle profit face of protecting of benefit.Monarch, compatibility is proper, is the optimum formula for the treatment of kidney-yang deficiency type colitis.Cordyceps: sweet, temperature.Go into kidney, lung two warps.The kidney tonifying sun, tonifying the lung, hemostasis and phlegm, tonifying deficiency.Herba Cistanches: sweet, sour, salty, temperature.Go into kidney, large intestine, spleen, liver, the bladder Five Classics.Reinforcing the kidney and supporting YANG, loosening bowel to relieve constipation, treatment deficiency and coldness diarrhea, hard masses softening and resolving.Actinolitum: salty, tepor.Go into kidney channel.Warming the kidney to invigorate YANG.The Cortex Eucommiae: sweet, little suffering, temperature.Go into liver, kidney two warps.Liver and kidney tonifying, strong muscles and bones, antiabortive hemostasis.Radix Polygoni Multiflori: bitter, sweet, puckery, tepor.Go into liver, kidney two warps.Liver and kidney tonifying, eliminating pathogen in the liver wind, heat-clearing and toxic substances removing.Semen Astragali Complanati: sweet, temperature.Go into the heart, liver, kidney three warps.Tonifying the kidney to consolidate the essence, nourishing the liver to improve visual acuity.Fructus Psoraleae: hot, bitter, big temperature.Go into spleen, kidney two warps.Kidney invigorating and YANG supporting, tonifying YANG Wen Han, controlling nocturnal emission with astringent drugs reducing urination, warming YANG antidiarrheal, antiabortive leukorrhagia stopping.Folium Ilicis Cornutae: hardship, flat.Go into liver, kidney two warps.Nourishing the liver and kidney, benefiting vital QI and blood, expelling wind and removing dampness, nourishing YIN and stopping bleeding, blood circulation promoting and blood stasis dispelling.Semen Trigonellae: hardship, temperature.Go into kidney, liver two warps.Warming the kidney to invigorate YANG is by cold damp eliminating.Semen juglandis: hot, sweet, temperature, gross weight is puckery.Go into lung, kidney, large intestine three warps.Tonifying the kidney to consolidate the essence, improving inspiration by invigorating kidney-QI Dingchuan, loosening bowel to relieve constipation.Rhizoma Drynariae: hardship, temperature.Go into liver, kidney two warps.The kidney invigorating is invigorated blood circulation, is continued and hinder pain relieving, alopecia areata, clavus.Stalactitum: hardship, temperature.Go into lung, kidney two warps.Kidney invigorating and YANG supporting, warming the lung is relievingd asthma, following milk, replenishing vital essence to improve eyesight, QI invigorating warming the spleen.Semen Nelumbinis: sweet, puckery, flat.Go into the heart, spleen, kidney three warps.Spleen reinforcing antidiarrheal, kidney tonifying ends something lost, tranquilizing by nourishing the heart.Hippocampus: sweet, temperature.Go into liver, kidney two warps.Kidney invigorating and YANG supporting, regulating qi and activating blood analgesic therapy, mass dissipating and swelling eliminating.Stichopus japonicus: salty, sweet, cold.Go into the heart, kidney two warps.The kidney invigorating and essence nourishing, blood enriching and dryness moistening.Testis et penis callorhini: sweet, salty, big heat.Go into liver,kidney,spleen three warps.Warming the kidney tonifying YANG, the smart marrow of mending of benefit.Fructus Mori: sweet, cold.Go into liver, kidney, the heart three warps.Liver and kidney tonifying increases liquid and promotes the production of body fluid, nourishing YIN and benefiting blood, life lengthening.Herba Taxilli: bitter, sweet, flat.Go into liver, kidney two warps.Invigorating the liver and kidney, benefiting essence-blood, wind-damp dispelling, the meridian dredging, the arteries and veins that nourishes blood, antiabortive unit.Semen Cuscutae: sweet, hot, flat.Go into liver, kidney two warps.Tonifying the kidney to consolidate the essence, tonifying liver makes eye bright, spleen reinforcing antidiarrheal, solid and gas is prevented miscarriage.Fructus Jujubae: sweet, warm.Go into spleen, stomach two warps.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, the mitigation property of medicine.Rhizoma Dioscoreae: sweet, flat.Go into spleen, lung, kidney three warps.Strengthening the spleen and nourishing the stomach, the kidney invigorating arresting seminal emission, replenishing and restoring lung-QI, treatment arthralgia due to stagnation of blood resistance network, emergency detoxifcation.Semen Tritici aestivi: sweet, cold.Go into the heart, spleen, kidney three warps.Strengthening the spleen, clearing heat and moistening dryness, styptic powder blood nourish heart.Radix Pseudostellariae: sweet, little hardship, tepor.Go into spleen, lung two warps.Mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Gallus Domesticus: sweet, flat.Go into liver, kidney two warps.Yin nourishing is brought down a fever.Caulis et Folium Brassicae capitatae: sweet, flat, nontoxic.Go into stomach, kidney two warps.Benefit kidney and replenishing marrow and stomach and alleviating pain.Arillus Longan: sweet, warm.Go into the heart, spleen two warps.Invigorating the heart and spleen, nourishing blood to tranquillize the mind, nourishing the lung to arrest cough.The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Go into spleen, stomach two warps.Air making-up and spleen enlivening, drying dampness to eliminate phlegm, diuretic detumescent, expelling wind and cold, strengthening superficial resistance to stop perspiration, QI invigorating are antiabortive.Radix Paeoniae Alba: bitter, sour, be slightly cold.Go into liver, spleen two warps.Nourishing blood to suppress the hyperactive liver, astringing YIN to stop sweating, slow middle pain relieving, suppressing liver-YANG.Radix Panacis Quinquefolii: hot, sweet, bitter, cold.Go into the heart, lung, stomach, kidney, the large intestine Five Classics.QI invigorating tonifying YIN, clearing away heat and promoting production of body fluid, clearing away heat to stop bleeding.Radix Angelicae Sinensis: hot, sweet, temperature.Go into the heart, liver, spleen, lung four warps.Nourish blood and blood, promoting blood circulation and stopping pain, nourishing blood for regulating menstruation, loosening bowel to relieve constipation, sending down the abnormal ascending QI cough-relieving treatment headache, fever due to internal injury.Radix Codonopsis: sweet, flat.Go into lung, spleen two warps.Replenishing QI to invigorate the spleen, supplementing QI for promoting the production of body fluid, QI invigorating heat extraction.Fructus Alpiniae Oxyphyllae: suffering, temperature.Go into spleen, stomach two warps.Warm spleen cold expelling, the kidney warming tonify deficiency.The Radix Astragali: sweet, tepor, nontoxic.Go into lung, spleen two warps.Tonifying Qi and lifting yang, hemostasis by invigorating QI, QI invigorating row stagnate, blood stasis removing eliminating stagnation, benefiting QI for strengthening the superficies, QI invigorating tonifying YIN, inducing diuresis to remove edema, warming the interior cold expelling, pus expelling by strengthening vital QI granulation promoting, strong body constitution, life lengthening.Rhizoma Polygonati: sweet, flat, nontoxic.Go into spleen, lung, kidney three warps.Control deficiency of lung-YIN cough, control pulmonary tuberculosis hemoptysis, beneficial able-bodied muscles and bones, control interior-heat and quench one's thirst, control weakness of the spleen and stomach.Semen oryzae sativae: sweet, flat.Go into spleen, stomach two warps.Invigorating the spleen and replenishing QI, invigorating spleen to remove dampness.Nidus collocaliae: sweet, flat, salty, little poison.Go into the heart, lung, spleen, stomach, the kidney Five Classics.Nourishing YIN and moistening the lung, QI invigorating invigorating middle warmer.Rhizoma Zingiberis: hot, hot.Go into spleen, stomach, lung three warps.Warming middle-JIAO by cold, recuperating depleted YANG is promoted blood circulation, the expectorant therapeutic method to keep the adverse QI flowing downwards, warming the lung to resolve fluid-retention, warming the meridian for stopping bleeding, control carbuncle from the beginning of.Ganoderma lucidum seu Japonicum: sweet, flat.Go into kidney, liver, the heart, lung four warps.Smart guarantor is refreshing for benefit, hard muscle profit face, and ear is filled in the kidney invigorating, eliminating impediment dispels the wind.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.
The specific embodiment
Get Cordyceps 9g, Herba Cistanches 6g, Actinolitum 3g, Cortex Eucommiae 6g, Radix Polygoni Multiflori 9g, Semen Astragali Complanati 3g, Fructus Psoraleae 6g, Folium Ilicis Cornutae 9g, Semen Trigonellae 3g, semen juglandis 9g, Rhizoma Drynariae 6g, Stalactitum 3g, Semen Nelumbinis 9g, hippocampus 3 g, Stichopus japonicus 3g, Testis et penis callorhini 3g, Fructus Mori 9g, Herba Taxilli 3g, Semen Cuscutae 6g, Fructus Jujubae 9g, Rhizoma Dioscoreae 3g, Semen Tritici aestivi 9g, Radix Pseudostellariae 6g, Gallus Domesticus 6g, Caulis et Folium Brassicae capitatae 6g, Arillus Longan 3g, Rhizoma Atractylodis Macrocephalae 6g, Radix Paeoniae Alba 6g, Radix Panacis Quinquefolii 6g, Radix Angelicae Sinensis 6g, Radix Codonopsis 6g, Fructus Alpiniae Oxyphyllae 3g, Radix Astragali 3g, Rhizoma Polygonati 6g, Semen oryzae sativae 9g, Nidus collocaliae 9g, Rhizoma Zingiberis 3g, Ganoderma lucidum seu Japonicum 6g and Radix Glycyrrhizae 9g, more than 39 the flavor medicines put into 1800 ml waters together, soaked 30 minutes, slow fire is fried 30 minutes then, filter and remove residue, fried medicinal liquid are the Chinese medicine for the treatment of kidney-yang deficiency type colitis.Boil medicine altogether 390 milliliters of liquid, when the patient of kidney-yang deficiency type colitis need treat, making fluid temperature was 36 ℃, each 130 milliliters, oral, every day three times, two is a course for the treatment of, if symptom is still deposited, obeys for second course for the treatment of again, so that recovery from illness.
Among the 376 routine kidney-yang deficiency type colitis patients, male's 215 examples account for 57.18%; Women's 161 examples account for 42.82%.The male is more than the women.
Table one, 376 routine kidney-yang deficiency type colitis patient's age scopes
Age (year) 18~25 26~35 36~50 51~56
The example number 3 237 131 5
Percentage ratio 0.8% 63.03% 34.84% 1.33%
Table two, 376 routine kidney-yang deficiency type colitis patient curative effect tables
Curative effect Cure Take a turn for the better Invalid
The example number 375 1 Do not have
Percentage ratio 99.73% 0.27% Do not have
Table three, 376 routine kidney-yang deficiency type colitis patients show the course for the treatment of
The treatment natural law 3~5 6~10 11~15 16~25
The example number 7 351 15 3
Percentage ratio 1.86% 93.35% 3.99% 0.8%
Information slip before and after table four, the 376 routine kidney-yang deficiency type colitis patient treatments
Figure 406439DEST_PATH_IMAGE002

Claims (1)

1. Chinese medicinal preparation method for the treatment of kidney-yang deficiency type colitis, it is characterized in that: get Cordyceps 9 grams, Herba Cistanches 6 grams, Actinolitum 3 grams, the Cortex Eucommiae 6 grams, Radix Polygoni Multiflori 9 grams, Semen Astragali Complanati 3 grams, Fructus Psoraleae 6 grams, Folium Ilicis Cornutae 9 grams, Semen Trigonellae 3 grams, semen juglandis 9 grams, Rhizoma Drynariae 6 grams, Stalactitum 3 grams, Semen Nelumbinis 9 grams, the hippocampus 3 gram, Stichopus japonicus 3 grams, Testis et penis callorhini 3 grams, Fructus Mori 9 grams, Herba Taxilli 3 grams, Semen Cuscutae 6 grams, Fructus Jujubae 9 grams, Rhizoma Dioscoreae 3 grams, Semen Tritici aestivi 9 grams, Radix Pseudostellariae 6 grams, Gallus Domesticus 6 grams, Caulis et Folium Brassicae capitatae 6 grams, Arillus Longan 3 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, Radix Paeoniae Alba 6 grams, Radix Panacis Quinquefolii 6 grams, Radix Angelicae Sinensis 6 grams, Radix Codonopsis 6 grams, Fructus Alpiniae Oxyphyllae 3 grams, the Radix Astragali 3 grams, Rhizoma Polygonati 6 grams, Semen oryzae sativae 9 grams, Nidus collocaliae 9 grams, Rhizoma Zingiberis 3 grams, Ganoderma lucidum seu Japonicum 6 grams and Radix Glycyrrhizae 9 grams, above 39 flavor Chinese medicines are put into 1800 ml waters, soaked 30 minutes, slow fire is fried 30 minutes then, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine for the treatment of kidney-yang deficiency type colitis.
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