CN104524378A - Tendon-relaxing and collateral-activating tincture for treating chronic periarthritis of shoulder - Google Patents
Tendon-relaxing and collateral-activating tincture for treating chronic periarthritis of shoulder Download PDFInfo
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a tendon-relaxing and collateral-activating tincture for treating chronic periarthritis of shoulder. The tincture is prepared from the following raw materials in parts by weight: 12-18 parts of fortune drynaria rhizome, 10-20 parts of frankincense, 6-9 parts of herb of poisonous buttercrp, 10-15 parts of common burreed rhizome, 10-15 parts of Chinese wolfberry root-bark, 9-12 parts of fimbrate ephemerantha, 8-12 parts of herb of henry chloranthus, 9-16 parts of Chinese taxillus twig, 10-20 parts of cassia twig, 8-16 parts of liquorice root, 12-15 parts of pawpaw, 8-16 parts of twotooth achyranthes root, 15-20 parts of the root of kudzu vine, 15-20 parts of the fruit of Chinese wolfberry, and 9-15 parts of nux vomica. The tendon-relaxing and collateral-activating tincture directly acts on the affected part, and has an excellent permeation effect; the prescription of the tincture is developed according to the principles of the traditional Chinese medicine, and is capable of achieving effects of warming meridians to dissipate cold, activating meridians to stop pain, relaxing the muscles and stimulating the blood circulation, and the like; the obtained product is quick in response, short in course of treatment, and capable of preventing relapse.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture.
Background technology
Scapulohumeral periarthritis is a kind of chronic disease, is the chronic aseptic inflammation of the soft tissues such as shoulder joint Surrounding muscles, tendon, synovial bursa and joint capsule.Inflammation causes the outer adhesion of intraarticular, thus affects the activity of shoulder joint.Its lesion characteristic is extensive, and namely pain is extensive, function limitation is extensive, tenderness is extensive.The full name of scapulohumeral periarthritis is scapulohumeral periarthritis, and primary disease is apt to occur in the people of about 50 years old, therefore also known as " bursitis of shoulder ", female patient is more than male (about 3: 1), and left shoulder is more than right shoulder.After ill, can not move in joint, and Buddhist is frozen or solidify, therefore claim " congealed shoulder ", " scapulohumeral periarthritis ".Scapulohumeral periarthritis, cause is shoulder joint surrounding tissue, if flesh thorax, synovial bursa etc. are by caused by freezing, wound, infection.Many patients are caused by rheumatism.Its cardinal symptom is neck shoulder constant pain, and ipsilateral upper limb is raised, rotate, swing is limited, meets wind and meets cold sensation and have heavy dull pain.This sick pain feature is arm once dynamic pain, motionless bitterly or slightly not bitterly, comb one's hair, wear the clothes, extract, elevate and all have any problem.Can hurt like hell when showing effect serious, lie awake all night.As treated not in time, delay and with the passing of time can make joint accretion, ipsilateral upper limb attenuates, and unablely even forms disuse atrophy.Congealed shoulder is chronic disease, and most patient is by modes such as functional exercise, massage, massages and bound drug treatment can transfer recovery from illness well gradually, and the patient that frequent long-term drug therapy is invalid, then should take operative treatment.Publication number CN 104138540 A(application number 201410338361.7) Chinese patent literature disclose scapulohumeral periarthritis plaster, raw material composition has: Herba speranskiae tuberculatae, Herba Taraxaci, Radix Et Rhizoma Rhei, Myrrha, the Radix Paeoniae Alba, Cortex cercis chinensis 10-20 part, Folium Isatidis, Rhizoma Cyperi, Cortex Cinnamomi, Flos Caryophylli, Cortex Mori, Radix Stephaniae Tetrandrae 5-10 part, Rhizoma Et Radix Notopterygii, Radix Clematidis, Rhizoma Polygoni Cuspidati, Poria 10-15 part, Semen Cuscutae, Squama Manis, Stigma Maydis, Rhizoma Cimicifugae, Caulis Polygoni Multiflori, Radix Angelicae Sinensis 15-20 part.Publication number CN 104096162 A(application number 201310115168.2) Chinese patent literature disclose a kind of plaster of cure scapulohumeral periarthritis, form primarily of 11 kinds of crude drug such as Radix Clematidis, Herba Lycopodii, Herba speranskiae tuberculatae, Radix Dipsaci, Rhizoma Corydalis, Ramulus Mori, Lignum Sappan.Publication number CN 104056059 A(application number 201410223874.3) Chinese patent literature disclose a kind of external application Chinese medicine of cure scapulohumeral periarthritis, former medicine composition has Radix Platycodonis 10-12, Radix Glycyrrhizae 5-8, Radix Et Rhizoma Rhei 2-4, Pseudobulbus Cremastrae Seu Pleiones 5-7, Rhizoma Paridis 2-4, Fructus Broussonetiae 1-3, Radix Trichosanthis 4-6, Olibanum 2-4, Bombyx Batryticatus 1-3, Herba Schizonepetae 5-6, Radix Clematidis 3-5, Herba Asari 2-4, Radix Dipsaci 1-3, Pyritum 2-4, Rhizoma Drynariae 7-9, Iris speculatrix Hance 2-3, Phyla nodiflora 1-3, Herba Violae arcuatae 2-4 and Radix Viburni Utilis 3-5.
For the treatment of scapulohumeral periarthritis, Western medicine adopts the Drug therapy of antipyretic analgesic, but only can reach the effect of alleviation, can not treating both the principal and secondary aspects of a disease, some traditional Chinese medicine formulas, curative effect is bad, easily recurs, well can not effect a radical cure scapulohumeral periarthritis, therefore, need to work out a kind of eutherapeutic traditional Chinese medical science formula newly.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of effective Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture easy to use, safe.
Technical scheme of the present invention is:
A kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is prepared from primarily of following bulk drugs, is weight portion: Rhizoma Drynariae 12-18, Olibanum 10-20, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 6-9, Rhizoma Sparganii 10-15, Cortex Lycii 10-15, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 9-12, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 8-12, Herba Taxilli 9-16, Ramulus Cinnamomi 10-20, Radix Glycyrrhizae 8-16, Fructus Chaenomelis 12-15, Radix Achyranthis Bidentatae 8-16, Radix Puerariae 15-20, Fructus Lycii 15-20, Semen Strychni 9-15.
In preferred scheme, Rhizoma Drynariae 14-16, Olibanum 12-18, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 7-8, Rhizoma Sparganii 11-14, Cortex Lycii 11-14, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10-11, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 9-11, Herba Taxilli 11-14, Ramulus Cinnamomi 12-18, Radix Glycyrrhizae 10-14, Fructus Chaenomelis 13-14, Radix Achyranthis Bidentatae 10-14, Radix Puerariae 16-19, Fructus Lycii 16-19, Semen Strychni 11-13.
Be more preferably, Rhizoma Drynariae 15, Olibanum 15, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 7.5, Rhizoma Sparganii 12.5, Cortex Lycii 12.5, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10.5, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 10, Herba Taxilli 12.5, Ramulus Cinnamomi 15, Radix Glycyrrhizae 12, Fructus Chaenomelis 13.5, Radix Achyranthis Bidentatae 12, Radix Puerariae 17.5, Fructus Lycii 17.5, Semen Strychni 12.
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with milk, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating, put into and pick clean Olibanum, heating is boiled and is melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, pulverized 40-80 mesh sieve and (preferably, pulverized 50-70 mesh sieve together with above-mentioned steps (1), (2) and (3) made crude drug; Be more preferably, pulverized 60 mesh sieves), by the ethanol of 70%, reflux, extract, at 90 DEG C, filter, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, the 0.2-0.4 of the amount Fructus Chaenomelis quality of step (2) milk doubly (preferred, the amount of milk is 0.3 times of Fructus Chaenomelis quality).
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, the volume ratio of step (3) vinegar and water is 1:10.
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, the amount of step (3) vinegar and water was not for there just to be Olibanum 1cm.
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, the amount of step (4) 70% ethanol is the 6-8 of total raw material medicine quality doubly (preferred, the amount of 70% ethanol is 7 times of total raw material medicine quality).
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, step (4) reflux, extract, 8-10 hour (preferably, reflux, extract, 8.5-9.5 hour; Be more preferably, reflux, extract, 9 hours).
The preparation method of described a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, step (5) turn little fire decocts 20-40 minute, and (preferred, 25-35 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 30 minutes).
A kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture provided by the invention not only has the prescription of science, and products obtained therefrom is easy to use.In addition, excellent results of the present invention also shows:
1, product of the present invention goes directly affected part, has good osmotic effect;
2, prescription of the present invention develops according to Chinese medicine principle, has the effects such as dispelling cold by warming the meridian, removing obstruction in the collateral to relieve pain, relaxing muscles and tendons to promote blood circulation;
3, products made thereby instant effect of the present invention, short treating period, can anti-ly recur.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is prepared from primarily of following bulk drugs, every part of 10g: Rhizoma Drynariae 12 parts, Olibanum 10 parts, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 6 parts, Rhizoma Sparganii 10 parts, Cortex Lycii 10 parts, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 9 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 8 parts, Herba Taxilli 9 parts, Ramulus Cinnamomi 10 parts, 8 parts, Radix Glycyrrhizae, Fructus Chaenomelis 12 parts, Radix Achyranthis Bidentatae 8 parts, Radix Puerariae 15 parts, Fructus Lycii 15 parts, Semen Strychni 9 parts.
The preparation method of above-mentioned a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with the milk of Fructus Chaenomelis quality 0.2 times, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating (volume ratio of vinegar and water is 1:10), put into and pick clean Olibanum, vinegar and water did not just have Olibanum 1cm, and heating is boiled and melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, 40 mesh sieves were pulverized together with above-mentioned steps (1), (2) and (3) made crude drug, with the ethanol of 70% of total raw material medicine quality 6 times, reflux, extract, 8 hours at 90 DEG C, filters, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct 20 minutes, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
embodiment 2a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is prepared from primarily of following bulk drugs, every part of 10g: Rhizoma Drynariae 18 parts, Olibanum 20 parts, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 9 parts, Rhizoma Sparganii 15 parts, Cortex Lycii 15 parts, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 12 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 12 parts, Herba Taxilli 16 parts, Ramulus Cinnamomi 20 parts, 16 parts, Radix Glycyrrhizae, Fructus Chaenomelis 15 parts, Radix Achyranthis Bidentatae 16 parts, Radix Puerariae 20 parts, Fructus Lycii 20 parts, Semen Strychni 15 parts.
A kind of preparation method of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with the milk of Fructus Chaenomelis quality 0.4 times, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating (volume ratio of vinegar and water is 1:10), put into and pick clean Olibanum, vinegar and water did not just have Olibanum 1cm, and heating is boiled and melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, 80 mesh sieves were pulverized together with above-mentioned steps (1), (2) and (3) made crude drug, with the ethanol of 70% of total raw material medicine quality 8 times, reflux, extract, 10 hours at 90 DEG C, filters, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct 40 minutes, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
Model case: xxx, female, 46 years old.Main suit: the year before, without obvious inducement right shoulder occasional pain, is difficult to lift, after rest, symptom takes a turn for the better and disappears, over nearly one month, and right shoulder pain aggravation, limitation of activity, can not go up act, after revolve, abduction, night, pain increased the weight of, and can not lean to one side to the right in bed, have tenderness.Medical history: patient once suffered from mild hypertension 1 year, medical check, unbearably, upper act 20 degree, abduction 40 degree, can not bend and appear on the stage patient pain, and shoulder has obvious pressure pain point, is diagnosed as Chronic Periarthritis.
Use a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral of the present embodiment gained tincture, every day 2 times, directly smear at every turn or be sprayed on affected part, 10 days courses for the treatment of.Use after 5 days, pain obviously alleviates, and continues a course for the treatment of of use, and tenderness disappears, and can freely stand up in bed, and after using three courses for the treatment of, patient's right arm can freely activity, and Shoulder Function recovers completely, patient's recovery from illness.
embodiment 3a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is prepared from primarily of following bulk drugs, every part of 10g: Rhizoma Drynariae 14 parts, Olibanum 12 parts, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 7 parts, Rhizoma Sparganii 11 parts, Cortex Lycii 11 parts, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 9 parts, Herba Taxilli 11 parts, Ramulus Cinnamomi 12 parts, 10 parts, Radix Glycyrrhizae, Fructus Chaenomelis 13 parts, Radix Achyranthis Bidentatae 10 parts, Radix Puerariae 16 parts, Fructus Lycii 16 parts, Semen Strychni 11 parts.
A kind of preparation method of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with the milk of Fructus Chaenomelis quality 0.2 times, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating (volume ratio of vinegar and water is 1:10), put into and pick clean Olibanum, vinegar and water did not just have Olibanum 1cm, and heating is boiled and melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, 50 mesh sieves were pulverized together with above-mentioned steps (1), (2) and (3) made crude drug, with the ethanol of 70% of total raw material medicine quality 6 times, reflux, extract, 8.5 hours at 90 DEG C, filters, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct 25 minutes, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
Model case: xxx, man, 61 years old.Main suit: suffer from Chronic Periarthritis 2 years, over nearly two months, right shoulder swelling is obvious, and intertubercular sulcus and triangular muscle attachment place have obvious tenderness sense, there is atrophy in triangular muscle, shoulder pain is obvious, and night, the pain increased, right shoulder can lift a bit slightly, front act abduction 40 degree, after stretch 25 degree.Once take antibiotic medicine and Dressed plaster (concrete medicine name is not quite clear), and only can reach lenitive effect for the moment.
Through a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral of people's recommendation the present embodiment gained tincture, twice daily, directly smear at every turn or be sprayed on affected part, 10 days courses for the treatment of.After using a course for the treatment of, affected part swelling disappears substantially, and pain also obviously alleviates, and after continuing two courses for the treatment of of use, patient pain disappears completely, and all malaise symptoms all disappear, and right shoulder can be freely movable, and patient's recovery from illness, follows up a case by regular visits in latter 1 year, do not have recurrence.
embodiment 4a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is prepared from primarily of following bulk drugs, every part of 10g: Rhizoma Drynariae 16 parts, Olibanum 18 parts, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 8 parts, Rhizoma Sparganii 14 parts, Cortex Lycii 14 parts, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 11 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 11 parts, Herba Taxilli 14 parts, Ramulus Cinnamomi 18 parts, 14 parts, Radix Glycyrrhizae, Fructus Chaenomelis 14 parts, Radix Achyranthis Bidentatae 14 parts, Radix Puerariae 19 parts, Fructus Lycii 19 parts, Semen Strychni 13 parts.
A kind of preparation method of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with the milk of Fructus Chaenomelis quality 0.4 times, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating (volume ratio of vinegar and water is 1:10), put into and pick clean Olibanum, vinegar and water did not just have Olibanum 1cm, and heating is boiled and melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, 70 mesh sieves were pulverized together with above-mentioned steps (1), (2) and (3) made crude drug, with the ethanol of 70% of total raw material medicine quality 8 times, reflux, extract, 9.5 hours at 90 DEG C, filters, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct 35 minutes, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
embodiment 5a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is prepared from primarily of following bulk drugs, every part of 10g: Rhizoma Drynariae 15 parts, Olibanum 15 parts, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 7.5 parts, Rhizoma Sparganii 12.5 parts, Cortex Lycii 12.5 parts, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10.5 parts, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 10 parts, Herba Taxilli 12.5 parts, Ramulus Cinnamomi 15 parts, 12 parts, Radix Glycyrrhizae, Fructus Chaenomelis 13.5 parts, Radix Achyranthis Bidentatae 12 parts, Radix Puerariae 17.5 parts, Fructus Lycii 17.5 parts, Semen Strychni 12 parts.
A kind of preparation method of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with the milk of Fructus Chaenomelis quality 0.3 times, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating (volume ratio of vinegar and water is 1:10), put into and pick clean Olibanum, vinegar and water did not just have Olibanum 1cm, and heating is boiled and melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, 60 mesh sieves were pulverized together with above-mentioned steps (1), (2) and (3) made crude drug, with the ethanol of 70% of total raw material medicine quality 7 times, reflux, extract, 9 hours at 90 DEG C, filters, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct 30 minutes, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Drynariae: base is former: be the dry rhizome of Plants of Polypodiaceae Mongolian oak Herba pteridii latiusculi.Nature and flavor: bitter, temperature.Gui Jing: return kidney, Liver Channel.Function cures mainly: the kidney invigorating bone strengthening, continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.
Olibanum: base is former: be the gum resin of olive subject plant Boswellia carterii Birdw.Nature and flavor: pungent, bitter, temperature.Gui Jing: enter the heart, liver, spleen channel.Function cures mainly: promoting blood circulation and stopping pain.For all pains of trusted subordinate, the contracture of muscle arteries and veins, traumatic injury, sore, carbuncle and painful swelling; Externally used detumescence granulation promoting.
Herba Ranunculi Scelerati (Radix Anemones rupicolae): base is former: be the herb of Ranunculaceae ranunculus Herba Ranunculi Scelerati (Radix Anemones rupicolae).Nature and flavor: bitter, pungent are flat.Poisonous.Function cures mainly: detumescence, eliminating stagnation of drawing out pus by applying a plaster to the affected part, preventing the attack (or recurrence) of malaria.For tuberculous lymphadenitis, malaria, carbuncle, venom, chronic ulcer of the lower limb.
Rhizoma Sparganii: base is former: be the dry tuber of Sparganiaceae plant rhizoma scirpi.Nature and flavor: pungent, bitter are flat.Gui Jing: return liver, spleen channel.Function cures mainly: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
Cortex Lycii: have: be the dry root bark of matrimony vine of solanaceae plant or lycium barbarum.Nature and flavor: sweet, cold.Gui Jing: return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.
Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh.: base is former: be the stem of the orchid family Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh..Nature and flavor: sweet, light are flat.Function cures mainly: replenishing YIN and removing heat.Cure mainly consumption of body fluid caused by febrile disease, lips and teeth are dry, hectic fever, night sweat, arthritis.
Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae): base is former: be the root of Chloranthaceae Chloranthus plant Herba chloranthi japonici.Nature and flavor: pungent, bitter, temperature.Poisonous.Function cures mainly: cold expelling cough-relieving, promoting blood circulation and stopping pain, and dissipating blood stasis detoxifies.For cough due to wind and cold, rheumatic ostalgia, amenorrhea; Traumatic injury is controlled in external, and congestion swells and ache, venom.The infusion of 5% can kill wriggler.
Herba Taxilli: base is former: be the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli.Nature and flavor: bitter, sweet, flat.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.
Ramulus Cinnamomi: base is former: be the dry twig of canella Cortex Cinnamomi.Nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Function cures mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Radix Glycyrrhizae: base is former: be the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Nature and flavor: sweet are flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Fructus Chaenomelis: base is former: be the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.Nature and flavor: acid, temperature.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
Radix Achyranthis Bidentatae: base is former: be the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Nature and flavor: bitter, sour are flat.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Radix Puerariae: base is former: be the dry root of legume pueraria lobata or Radix Puerariae rattan.Nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Fructus Lycii: base is former: be the dry mature fruit of plant of Solanaceae lycium barbarum.Nature and flavor: sweet are flat.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Semen Strychni: base is former: be the dry mature seed of loganiaceae plant Semen Strychni.Nature and flavor: bitter, temperature; Very toxic.Gui Jing: return liver, spleen channel.Function cures mainly: removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating.For rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain; Poliomyelitis sequela, rheumatoid arthritis.
test example 1the clinical practice of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture (embodiment 5) of gained of the present invention:
Object of study: between in March ,-2013 in January, 2011, screen 413 examples in hospital orthopedics outpatient service and be diagnosed as Chronic Periarthritis patient, wherein women 221 example, male 192 example, oldest 63 years old, minimal ages 38 years old, 51.2 years old mean age, the course of disease 1 month-3 years, average course of disease 1.4 years.Clinical symptoms: shoulder pain, increases the weight of when night or shoulder activity; Shoulder mobility is limited, and mobility obviously reduces, the extensive tenderness of periarticular.Inclusive criteria: 1, the middle-older patient at 30 ~ 75 years old age, has hemiplegia history, has shoulder to damage history or once had the fixing history in local, or having rheumatism attacked by the cold and evil history; 2, slowly fall ill, shoulder pain and movable pain, rest pain, increases the weight of when night or shoulder activity; 3, shoulder mobility abduction, upper act, after stretch and inside and outsidely revolve limitation of activity, especially limited comparatively serious with outward turning; 4, take on that front, shoulder are prominent, under acromion, between omoplate, there is tenderness at triangular muscle attachment place, the place such as intertubercular sulcus.Exclusion standard: 1, x-ray inspection diagnosis Osteoarthritis; 2, study local in first 2 weeks and use the patient of 17-hydroxy-11-dehydrocorticosterone; 3, concurrent serious condition person (liver, kidney and hematological); 4, drug allergy history patient is had; 5, gestation and age of sucking patient; 6, the patient of acquisition information is difficult to and other are unsuitable for including in the patient of this research.
Test method: patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group uses products obtained therefrom of the present invention, twice daily, it is directly smeared or is sprayed on affected part, and 10 days courses for the treatment of, matched group uses other medicine, as conventional medication such as shoulder pain moxibustion, magnet therapeutic plaster, scapulohumeral periarthritis subsides, YUNNAN BAIYAO cream.Treatments period carries out Continuous Observation to two groups of patients, and record symptom variation and untoward reaction situation, add up therapeutic outcome after two months, follow up a case by regular visits to after 1 year, statistics recurrence.
Curative effect situation criterion: evaluate with reference to the criterion of therapeutical effect in " Chinese medical disease Standardization of diagnosis and curative effect ".Cure: shoulder joint function recovers normal, and pain disappears, around without tenderness and sensitive spot; Effective: shoulder pain and tenderness disappear substantially, and shoulder mobility obviously improves; Effective: pain obviously alleviates, shoulder joint function activity makes moderate progress; Invalid: shoulder pain and shoulder mobility scope are all not improved or unchanged.
Therapeutic outcome is as shown in table 1.
Two groups of patient treatment situations after two months treated by table 1
As shown in Table 1: in experimental group, pain disappear, joint function recovery have 104 examples (41.1%), effective number of cases 101 example (39.9%) that pain disappears substantially, the patient that pain obviously alleviates has 37 examples (14.6%), experimental group total effective rate 95.6%.In matched group, healing, effective and effective number of cases are respectively 33 examples, 67 examples and 35 examples, and the total effective rate of matched group is 84.4%, and therapeutic effect is obviously not as experimental group.More several conventional medicine of the therapeutic effect of visible products obtained therefrom of the present invention to scapulohumeral periarthritis is good.And treatments period two groups of patients all do not occur untoward reaction, follow up a case by regular visits to after 1 year, all patients of experimental group all do not have recurrence, and matched group has 4 routine patients' appearance recurrences in various degree.
The present invention selects the kidney invigorating bone strengthening, continuous Rhizoma Drynariae of hindering pain relieving; The Olibanum of promoting blood circulation and stopping pain; The Herba Ranunculi Scelerati (Radix Anemones rupicolae) of detumescence; The Rhizoma Sparganii of removing food stagnancy pain relieving; Removing heat from blood is except the Cortex Lycii steamed; The Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. of replenishing YIN and removing heat; The Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) of promoting blood circulation and stopping pain, dissipating blood stasis removing toxic substances; The Herba Taxilli of bone and muscle strengthening, invigorating the liver and kidney; The Ramulus Cinnamomi of warming the meridian and promoting blood circulation, supporing yang activating QI; The Radix Glycyrrhizae of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing; The Fructus Chaenomelis of suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness; The biological Radix Achyranthis Bidentatae of eliminating blood stasis and inducing menstruation; The Radix Puerariae of expelling pathogenic factors from muscles for reducing heat; The Fructus Lycii of nourishing the liver and kidney; The Semen Strychni of removing obstruction in the collateral to relieve pain, all medicines share, and the effects such as collaborative performance dispelling cold by warming the meridian, removing obstruction in the collateral to relieve pain, relaxing muscles and tendons to promote blood circulation, the scapulohumeral periarthritis caused for many reasons all has comparatively significant curative effect.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. a Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture, is characterized in that, is prepared from primarily of following bulk drugs, be weight portion: Rhizoma Drynariae 12-18, Olibanum 10-20, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 6-9, Rhizoma Sparganii 10-15, Cortex Lycii 10-15, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 9-12, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 8-12, Herba Taxilli 9-16, Ramulus Cinnamomi 10-20, Radix Glycyrrhizae 8-16, Fructus Chaenomelis 12-15, Radix Achyranthis Bidentatae 8-16, Radix Puerariae 15-20, Fructus Lycii 15-20, Semen Strychni 9-15.
2. a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 1, is characterized in that, Rhizoma Drynariae 14-16, Olibanum 12-18, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 7-8, Rhizoma Sparganii 11-14, Cortex Lycii 11-14, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10-11, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 9-11, Herba Taxilli 11-14, Ramulus Cinnamomi 12-18, Radix Glycyrrhizae 10-14, Fructus Chaenomelis 13-14, Radix Achyranthis Bidentatae 10-14, Radix Puerariae 16-19, Fructus Lycii 16-19, Semen Strychni 11-13.
3. a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 1, is characterized in that, Rhizoma Drynariae 15, Olibanum 15, Herba Ranunculi Scelerati (Radix Anemones rupicolae) 7.5, Rhizoma Sparganii 12.5, Cortex Lycii 12.5, Ephemerantha lonchophylla (Hook. F) Hunt et Sum-merh. [Ephemerantha fimbrate (Bl.) Hunt et Summerh. 10.5, Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 10, Herba Taxilli 12.5, Ramulus Cinnamomi 15, Radix Glycyrrhizae 12, Fructus Chaenomelis 13.5, Radix Achyranthis Bidentatae 12, Radix Puerariae 17.5, Fructus Lycii 17.5, Semen Strychni 12.
4. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as described in as arbitrary in claim 1-3, it is characterized in that, step is:
(1) get Herba Ranunculi Scelerati (Radix Anemones rupicolae) decontamination, cutting, put in frying pan, with moderate heat heating, fry to pitchy, spray yellow wine, go out most Mars, and slightly vexed, taking-up is dried;
(2) cleaned by Fructus Chaenomelis, soak, stew to moisten to thoroughly, be then placed in food steamer and cook with milk, take out, shave while hot, dries;
(3) get vinegar and water Hybrid Heating, put into and pick clean Olibanum, heating is boiled and is melted completely to Olibanum, and pour in cold water, after it solidifies, taking-up is dried;
(4) by other surplus stock medicine decontaminations except Herba Ranunculi Scelerati (Radix Anemones rupicolae), Fructus Chaenomelis and Olibanum, clean, dry, pulverized 40-80 mesh sieve and (preferably, pulverized 50-70 mesh sieve together with above-mentioned steps (1), (2) and (3) made crude drug; Be more preferably, pulverized 60 mesh sieves), by the ethanol of 70%, reflux, extract, at 90 DEG C, filter, collect immersion, filtering residue is for subsequent use;
(5) by step (4) remaining filtering residue, add water and do not have filtering residue 3cm, after heating boils 10 minutes, turn little fire and decoct, filter, collect filtrate, by made filtrate reduced in volume to 1/2 of original volume, immersion stirring and evenly mixing made with step (4) again, filters, obtains relaxing muscles and tendons and activating QI and blood in the collateral tincture.
5. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 4, is characterized in that, the 0.2-0.4 of the amount Fructus Chaenomelis quality of step (2) milk doubly (preferred, the amount of milk is 0.3 times of Fructus Chaenomelis quality).
6. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 4, is characterized in that, the volume ratio of step (3) vinegar and water is 1:10.
7. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 4, it is characterized in that, the amount of step (3) vinegar and water was not for there just to be Olibanum 1cm.
8. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 4, is characterized in that, the amount of step (4) 70% ethanol is the 6-8 of total raw material medicine quality doubly (preferred, the amount of 70% ethanol is 7 times of total raw material medicine quality).
9. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 4, is characterized in that, step (4) reflux, extract, 8-10 hour (preferably, reflux, extract, 8.5-9.5 hour; Be more preferably, reflux, extract, 9 hours).
10. the preparation method of a kind of Chronic Periarthritis relaxing muscles and tendons and activating QI and blood in the collateral tincture as claimed in claim 4, is characterized in that, step (5) turn little fire decocts 20-40 minute, and (preferred, 25-35 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 30 minutes).
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| CN101036696A (en) * | 2006-03-16 | 2007-09-19 | 通化衛京药业股份有限公司 | Medicine combination for curing orthopaedics disease and the method for preparing the same |
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| CN101036696A (en) * | 2006-03-16 | 2007-09-19 | 通化衛京药业股份有限公司 | Medicine combination for curing orthopaedics disease and the method for preparing the same |
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| 谢大成等: "自拟消骨痛酊配合推拿手法治疗肩周炎临床观察", 《湖北中医药大学学报》 * |
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| CN105288188A (en) * | 2015-11-06 | 2016-02-03 | 孙文菊 | Traditional Chinese medicine external application preparation and nursing method used for treating shoulder periarthritis |
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