CN104758638A - Traditional Chinese medicine composition for treating gallstone - Google Patents
Traditional Chinese medicine composition for treating gallstone Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gallstone. The traditional Chinese medicine composition is mainly prepared from the following raw medicinal materials in parts by mass: 8-15 parts of Indian buead, 10-15 parts of herb of drooping clinacanthus, 3-6 parts of mirabilite, 9-12 parts of szechwan chinaberry fruit, 8-12 parts of brooklet anemine root, 9-14 parts of white peony root, 10-13 parts of herb of spicate clerodendranthus, 9-13 parts of herb of Japanese hop, 11-14 parts of stem of noble dendrobium, 8-13 parts of bitter orange, 10-15 parts of heterophylly faalsestarwort root, 11-15 parts of stem and leaf of hongkong pavetta and 3-7 parts of pyrrosia leaf. The traditional Chinese medicine composition disclosed by the invention is obtained by summarizing years of clinical practices, and has the effects of clearing heat and removing toxicity as well as dispersing stagnated liver qi for promoting bile flow, is significant in curative effect, and can treat both symptoms and root causes.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of cholelithiasis.
Background technology
Cholelithiasis refers to the disease caused by calculus occurred in gallbladder, is a kind of commonly encountered diseases.Increase with the age, sickness rate also raises gradually, and women is obviously more than male.Can mucous membrane of gallbladder be stimulated after calculus is formed in gallbladder, not only can cause the chronic inflammatory disease of gallbladder, and when Incarcerated stone can also cause secondary infection after neck of gallbladder or cystic duct, cause the acute inflammation of gallbladder.Most patient is asymptomatic, only health check-up, perform the operation and become celestial time find, be called inactive cholelithiasis.The classical symptom of the cholelithiasis of a few patients is biliary colic, shows as acute or chronic cholecystitis.The treatment of current cholelithiasis mainly comprises operative treatment and non-operative treatment two class, traditional operation therapy instant effect, but risk is high, and greatly, easily recurrence and generation sequela, non-operative treatment comprises Drug therapy and rubble method for infringement and expense.
Publication No. CN 102988904 A(application number 201210560147.7) Chinese patent literature disclose a kind of medicine arranging cholelithiasis, the medicine of row's cholelithiasis of the present invention is made up of main formula and attached side; Main formula is composed of the following components: olive oil, Fructus Citri Limoniae juice; Attached side is made up of following medical material: Radix Bupleuri, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Rhizoma Cyperi, river Dong, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Fructus Aurantii, Radix Curcumae, Fructus Citri Sarcodactylis, Radix Astragali, Flos Chrysanthemi, Radix Gentianae, Herba Rabdosiae Lophanthoidis, Herba Artemisiae Scopariae, Herba Plantaginis, Herba Lysimachiae, Herba Houttuyniae, Rhizoma Alismatis, Endothelium Corneum Gigeriae Galli, Talcum, Radix Glycyrrhizae.Publication No. CN 103127464 A(application number 201310074595.0) Chinese patent literature disclose one and treat cholelithiasis Chinese medicine, it is characterized in that being made up of following prescription and weight: Lysimachia christinae Hance 10-20 gram, Rhizoma Polygoni Cuspidati 10-20 gram, Herba Artemisiae Scopariae 10-20 gram, Herba Aristolochiae Mollissimae 10-20 gram, root of Semen Coicis 10-30 gram, Herba Lysimachiae 15-30 gram, Rhizoma Phragmitis 15-30 gram, Radix Et Rhizoma Rhei 15-30 gram, Semen Plantaginis 10-15 gram, Radix Curcumae 10-15 gram, Endothelium Corneum Gigeriae Galli 8-15 gram, Fructus Crataegi 10-20 gram, Fructus Hordei Germinatus 10-20 gram, Radix Glycyrrhizae 2-10 gram.Publication No. CN 104225348 A(application number 201410540636.5) Chinese patent literature disclose a kind of Chinese medicine for the treatment of cholelithiasis, this medicine is prepared from by the raw material of Chinese medicine of following weight portion: each 15 parts of Radix Codonopsis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Achyranthis Bidentatae, Herba Artemisiae Scopariae, the Rhizoma Atractylodis Macrocephalae, the Rhizoma Anemarrhenae, Semen Cuscutae and Radix Glycyrrhizae, Folium Pyrrosiae 8 parts, Semen Abutili 6 parts, Rhizoma Polygoni Cuspidati 7 parts, Herba Lysimachiae 12 parts.
Be used for the treatment of the medicine of cholelithiasis at present, some therapeutic effect is poor, takes effect slow, also needs to study Chinese medicine formula further, to obtain the calculus medicine of a kind of determined curative effect, safety non-toxic.
Summary of the invention
For the problem of prior art, the object of this invention is to provide Be very effective, take the wide a kind of Chinese medicine composition for the treatment of cholelithiasis of safe and applicable.
Technical scheme of the present invention is:
Treat a Chinese medicine composition for cholelithiasis, be prepared from primarily of following bulk drugs, be mass parts: Poria 8-15; Herba Clinacanthi Nutantis 10-15; Natrii Sulfas 3-6; Fructus Toosendan 9-12; Radix Anemones Rivularis 8-12; Radix Paeoniae Alba 9-14; Herba clerodendranthi spicati 10-13; Herba humuli scandentis 9-13; Herba Dendrobii 11-14; Fructus Aurantii 8-13; Radix Pseudostellariae 10-15; Caulis et folium pavettae hongkongensis 11-15; Folium Pyrrosiae 3-7.
Preferred version is, Poria 10-13; Herba Clinacanthi Nutantis 11-14; Natrii Sulfas 4-5; Fructus Toosendan 10-11; Radix Anemones Rivularis 9-11; Radix Paeoniae Alba 11-12; Herba clerodendranthi spicati 11-12; Herba humuli scandentis 10-12; Herba Dendrobii 12-13; Fructus Aurantii 9-12; Radix Pseudostellariae 11-14; Caulis et folium pavettae hongkongensis 12-14; Folium Pyrrosiae 4-6.
More preferably, Poria 11.5; Herba Clinacanthi Nutantis 12.5; Natrii Sulfas 4.5; Fructus Toosendan 10.5; Radix Anemones Rivularis 10; The Radix Paeoniae Alba 11.5; Herba clerodendranthi spicati 11.5; Herba humuli scandentis 11; Herba Dendrobii 12.5; Fructus Aurantii 10.5; Radix Pseudostellariae 12.5; Caulis et folium pavettae hongkongensis 13; Folium Pyrrosiae 5.
Described a kind of Chinese medicine composition for the treatment of cholelithiasis, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts, collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug is pulverized together with Natrii Sulfas with step (1) (2) (3), is squeezed into tablet dosage form, obtains tablet.
Described a kind of preparation method for the treatment of the Chinese medicine composition tablet of cholelithiasis, step (4) turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes).
Described a kind of Chinese medicine composition for the treatment of cholelithiasis, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes), collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug pulverizes and sieves together with Natrii Sulfas with step (1) (2) (3), is packed in capsule, obtains capsule.
Described a kind of preparation method for the treatment of the Chinese medicinal composition capsules agent of cholelithiasis, it is (preferred: to pulverize 80-100 mesh sieve that step (5) pulverized 60-120 mesh sieve; Be more preferably: pulverized 90 mesh sieves).
Described a kind of Chinese medicine composition for the treatment of cholelithiasis, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes), collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate to paste, step (1) (2) (3) made crude drug and Natrii Sulfas are pulverized, mixes with paste, smash after oven dry, then add adjuvant, granulation, granulate, drying, pack and obtain granule.
Described a kind of preparation method for the treatment of the Chinese medicinal composition granules of cholelithiasis, the 4-7 that step (4) amount of water is boiled crude drug quality is doubly (preferred: amount of water is 5-6 times of made crude drug quality; Be more preferably: amount of water is 5.5 times of boiled crude drug quality).
Described a kind of Chinese medicine composition for the treatment of cholelithiasis, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes), collecting by filtration filtrate;
(5) step (1) (2) (3) made crude drug is pulverized and sieved together with Natrii Sulfas, be added in step (4) gained filtrate, stir, obtain decoction.
Described a kind of preparation method for the treatment of the Chinese medicine composition decoction of cholelithiasis, it is (preferred: to pulverize 120-140 mesh sieve that step (5) pulverized 100-160 mesh sieve; Be more preferably: pulverized 130 mesh sieves).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Poria: base is former: be the dry sclerotia of Polyporaceae plant Poria.Nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Herba Clinacanthi Nutantis: base is former: for rank of nobility dinner party section plant turns round the herb of sequence flower.Chemical analysis: rhizome is containing lupeol, betulin and cupreol.Nature and flavor: mildly bitter flavor; Light; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Relaxing muscles and tendons to promote blood circulation.Main jaundice due to damp-heat; Rheumatic arthralgia; Menoxenia; Treating swelling and pain by traumatic injury; Fracture.
Natrii Sulfas: base is former: the refining crystallization obtained through boiling-off for mineral Natrii Sulfas.Nature and flavor: arduous salty, cold.Gui Jing: enter stomach, large intestine channel.Function cures mainly: purge heat, and moisturizes, softening the hard mass.Control excess-heat to stagnate, abdominal distention constipation, retention of phlegm gathers, and mouth is red hides from view, erysipelas, carbuncle.
Fructus Toosendan: base is former: be the fruit of canella Fructus Toosendan.Chemical analysis: containing Toosendanin, alkaloid, kaempferol, resin, tannin.Nature and flavor: bitter, cold, poisonous.Gui Jing: enter liver, stomach, small intestine meridian.Function cures mainly: except damp and hot, clearing away liver-fire, pain relieving, parasite killing.Control epigastric pain with cold limbs due to adverseness of heat, hypochondriac pain, colic, abdominal pain due to worm stagnation.
Radix Anemones Rivularis: base is former: be the root of the grass that ranunculaceae plant Radix Anemones Rivularis and little Hua tiger slap.Nature and flavor: bitter; Pungent; Temperature; Mild toxicity.Gui Jing: lung; Stomach; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Relaxing muscles and tendons to promote blood circulation; Reducing swelling and alleviating pain.Main laryngopharynx swelling and pain; Mumps; Scrofula tuberculosis; Swollen ulcer drug; Malaria; Cough; Jaundice due to damp-heat; Rheumatalgia; Stomachache; Toothache; Traumatic injury.
The Radix Paeoniae Alba: base is former: be the root of ranunculaceae plant Radix Paeoniae (cultigen).Nature and flavor with return through, bitter, sour, be slightly cold.Return liver, spleen channel.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, stabilize effect of sun.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Herba clerodendranthi spicati: base is former: be the herb of labiate Herba clerodendranthi spicati.Chemical analysis: sulfur acid calcium, unknown organic acid calcium salt and potassium salt, volatile oil, Saponin, pentose, hexose, glucuronic acid etc.Leaf is containing meso inositol.Nature and flavor: sweet light micro-hardship are cool.Function cures mainly: clearing away heat-damp and promoting diuresis; Tonglin Paishi.Main acute and chronic nephritis; Cystitis; Lithangiuria; Cholelithiasis; Rheumatic arthritis.
Herba humuli scandentis: base is former: be the herb of moraceae plants Herba humuli scandentis.Chemical analysis: herb is containing luteolin, glycoside, choline and asparagine, and other still have volatile oil, tannin and resin.Cone is containing .alpha.-bitter acid and .beta.-bitter acid.Leaf is containing 0.015% cosmosiin, vitexin.Main containing β-Humuleno, caryophyllene, α-flaw in a piece of jade bar alkene, α-selinene, β-selinene and γ-Cadinene etc. in volatile oil.Nature and flavor: sweet; Bitter; Cold in nature.Gui Jing: lung; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis for treating stranguria syndrome; .Main cough due to lung-heat; Lung abscess; Deficiency-heat excessive thirst; Pyretic stranguria; Edema; Dysuria; Damp-heat dysentery; Pathopyretic ulcer; Skin pruritus.
Herba Dendrobii: base is former: be the stem of orchid Dendrobium nobile or its multiple congener.Nature and flavor: sweet light micro-salty, cold.Gui Jing: enter stomach, lung, kidney channel.Function cures mainly: promote the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN.Control consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, it is dark that the moon hinders order.
Fructus Aurantii: base is former: be the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..Nature and flavor with return through: bitter, pungent, sour, be slightly cold.Return spleen, stomach warp.There is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention, visceroptosis.
Radix Pseudostellariae: base is former: be the tuber of pinkwort Radix Ginseng.Chemical analysis: containing Palmic acid in Radix Pseudostellariae tuber lipid, linoleic acid, 1-glyceryl linoleate, pyrroles-2-carboxylic acid-3 '-furyl methyl ester, mountain acid, 2-pyrrole carboxylic acid, cupreol, separately sugary, aminoacid, trace element [manganese (13.4 μ g/g) etc.) and Radix pseudostellariae cyclic peptides A and B.Nature and flavor: sweet; Micro-hardship; Cold nature.Gui Jing: spleen, lung meridian.Function cures mainly: mend strengthening spleen and lung; Supplementing QI for promoting the production of body fluid.Main weakness of the spleen and stomach; Inappetence; Lassitude; Impairment of both QI and YIN; Dry cough expectorant is few; Spontaneous perspiration is breathed hard; And the convalescent stage of febrile disease deficiency of vital energy Tianjin wound; Interior-heat is thirsty; Or neurasthenia, palpitation and insomnia, dizzy forgetful, Infantile Summer Fever.
Caulis et folium pavettae hongkongensis: base is former: be the herb of Sphagnaceae plant spire bog moss.Nature and flavor: lightly seasoned micro-hardship, property is put down.Function cures mainly: clearing away heat to improve acuity of vision, moves back nebula, detumescence.Control corneal leukoma, conjunctival congestion and swelling pain.
Folium Pyrrosiae: base is former: be Plants of Polypodiaceae Folium Pyrrosiae, pyrrosia sheareriChing, pyrrosia gralla Ching, North China Folium Pyrrosiae and the herb having handle Wei etc.Nature and flavor: bitter; Sweet; Cold.Gui Jing: lung; Kidney; Urinary bladder channel.Function cures mainly: relieving stranguria by diuresis; Removing heat from the lung and dissipating phlegm; Cooling blood for hemostasis.Main gonorrhea; Edema; Dysuria; Expectorant heat syndrome cough is breathed heavily; Spitting of blood; Spit blood; Epistaxis; Metrorrhagia; Traumatic hemorrhage.
A kind of Traditional Chinese medicine composition formula science for the treatment of cholelithiasis provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, can effectively alleviate uncomfortable disease;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of clearing away heat-damp and promoting diuresis, dissipating blood stasis analgesic therapy;
3, Chinese crude drug selected by the present invention, cheap, and safety has no side effect, applied widely.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat a Chinese medicine composition for cholelithiasis, be prepared from (every part of 10g) primarily of following bulk drugs: 8 parts, Poria, Herba Clinacanthi Nutantis 10 parts, 3 parts, Natrii Sulfas, Fructus Toosendan 9 parts, Radix Anemones Rivularis 8 parts, the Radix Paeoniae Alba 9 parts, Herba clerodendranthi spicati 10 parts, Herba humuli scandentis 9 parts, Herba Dendrobii 11 parts, Fructus Aurantii 8 parts, Radix Pseudostellariae 10 parts, Caulis et folium pavettae hongkongensis 11 parts, Folium Pyrrosiae 3 parts.Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition tablet of cholelithiasis is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, be cut into silk or section after cleaning, add rice wine and infiltrate 14 minutes, slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 32 minutes, take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add the water soaking 16 minutes of boiled crude drug quality 6 times, intense fire is heated to boiling, turns little fire and decocts 29 minutes, collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug is pulverized together with Natrii Sulfas with step (1) (2) (3), is squeezed into tablet dosage form, obtains tablet.
embodiment 2treat a Chinese medicine composition for cholelithiasis, be prepared from (every part of 10g) primarily of following bulk drugs: 15 parts, Poria, Herba Clinacanthi Nutantis 15 parts, 6 parts, Natrii Sulfas, Fructus Toosendan 12 parts, Radix Anemones Rivularis 12 parts, the Radix Paeoniae Alba 14 parts, Herba clerodendranthi spicati 13 parts, Herba humuli scandentis 13 parts, Herba Dendrobii 14 parts, Fructus Aurantii 13 parts, Radix Pseudostellariae 15 parts, Caulis et folium pavettae hongkongensis 15 parts, Folium Pyrrosiae 7 parts.Above-mentioned a kind of preparation method for the treatment of the Chinese medicinal composition capsules agent of cholelithiasis is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, be cut into silk or section after cleaning, add rice wine and infiltrate 14 minutes, slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 32 minutes, take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add the water soaking 16 minutes of boiled crude drug quality 6 times, intense fire is heated to boiling, turns little fire and decocts 29 minutes, collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug pulverized 90 mesh sieves together with Natrii Sulfas with step (1) (2) (3), was packed in capsule, obtained capsule.
Model case: xxx, women, 43 years old.Main suit: epigastric discomfort, inappetence half a year; Medical history: patient occurred epigastric discomfort without obvious inducement before half a year, intermittent distending pain, with heating, because pain is comparatively light, do not go to a doctor, the rear state of an illness obviously increases the weight of, and finds there is calculus in gallbladder on inspection.
Because being reluctant operative treatment, just selecting expectant treatment, taking this example gained capsule, each 3-4 grain, warm boiled water, one day twice, within ten days, be a course for the treatment of, after patient takes a course for the treatment of, stomachache alleviates, continue to take two courses for the treatment of, uncomfortable disease is eliminated substantially, and calculus is discharged on inspection, consolidate again a course for the treatment of, patient fully recovers, and follows up a case by regular visits to 1 year, does not recur.
embodiment 3treat a Chinese medicine composition for cholelithiasis, be prepared from (every part of 10g) primarily of following bulk drugs: 10 parts, Poria, Herba Clinacanthi Nutantis 11 parts, 4 parts, Natrii Sulfas, Fructus Toosendan 10 parts, Radix Anemones Rivularis 9 parts, the Radix Paeoniae Alba 11 parts, Herba clerodendranthi spicati 11 parts, Herba humuli scandentis 10 parts, Herba Dendrobii 12 parts, Fructus Aurantii 9 parts, Radix Pseudostellariae 11 parts, Caulis et folium pavettae hongkongensis 12 parts, Folium Pyrrosiae 4 parts.Above-mentioned a kind of preparation method for the treatment of the Chinese medicinal composition granules of cholelithiasis is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, be cut into silk or section after cleaning, add rice wine and infiltrate 14 minutes, slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 32 minutes, take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add the water soaking 16 minutes of boiled crude drug quality 5.5 times, intense fire is heated to boiling, turns little fire and decocts 29 minutes, collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate to paste, step (1) (2) (3) made crude drug and Natrii Sulfas are pulverized, mixes with paste, smash after oven dry, then add adjuvant, granulation, granulate, drying, pack and obtain granule.
Model case: xxx, male, 53 years old.Medical history: patient obtains cholelithiasis 3 years, frequent right Upper abdominal pain, but pain is lighter, intermittence takes calculus medicine, does not carry out regular treatment, in nearly half a year, the state of an illness obviously increases the weight of, pain time increases, and does not move back, carry out hospital admission with heating, calculus 2*3cm in gallbladder, thickening of capsule wall of gallbladder, bile duct is broadening, is diagnosed as cholelithiasis.
Through doctor advised, adopt Chinese traditional treatment, take this example gained granule, each 3-4g, warm boiled water, one day twice, within ten days, be a course for the treatment of, after patient takes five days, heating paresthesia is eliminated, pain relief, take two courses for the treatment of, in gallbladder, calculus reduces gradually, uncomfortable disease is eliminated substantially, and after continuing a course for the treatment of, further consultation calculus disappears substantially, uncomfortable without other, patient fully recovers.
embodiment 4treat a Chinese medicine composition for cholelithiasis, be prepared from (every part of 10g) primarily of following bulk drugs: 13 parts, Poria, Herba Clinacanthi Nutantis 14 parts, 5 parts, Natrii Sulfas, Fructus Toosendan 11 parts, Radix Anemones Rivularis 11 parts, the Radix Paeoniae Alba 12 parts, Herba clerodendranthi spicati 12 parts, Herba humuli scandentis 12 parts, Herba Dendrobii 13 parts, Fructus Aurantii 12 parts, Radix Pseudostellariae 14 parts, Caulis et folium pavettae hongkongensis 14 parts, Folium Pyrrosiae 6 parts.Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition decoction of cholelithiasis is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, be cut into silk or section after cleaning, add rice wine and infiltrate 14 minutes, slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 32 minutes, take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add the water soaking 16 minutes of boiled crude drug quality 6 times, intense fire is heated to boiling, turns little fire and decocts 29 minutes, collecting by filtration filtrate;
(5) step (1) (2) (3) made crude drug was pulverized 130 mesh sieves together with Natrii Sulfas, and be added in step (4) gained filtrate, stir, obtain decoction.
Model case: xxx, women, 39 years old.Main suit: patient likes eating rich food dish, and do not like motion, before one week, after feed, there is Upper abdominal pain, emit cold sweat, and have radiation pain to scapular region, with Nausea and vomiting, poor appetite, on inspection, patient skin turns to be yellow, stringy and rolling pulse, and body of the tongue is white, and B ultrasonic is diagnosed as cholelithiasis.
Take this example gained decoction, each 100-180ml, warmly to take, one day twice ten days is a course for the treatment of, after patient takes three days, the uncomfortable disease such as Nausea and vomiting alleviates, and pain relief, after continuing to take two courses for the treatment of, pain disappears, on inspection, in gallbladder, calculus is discharged, and spirit takes a turn for the better, appetite recovers normal, recovery from illness.
embodiment 5treat a Chinese medicine composition for cholelithiasis, be prepared from (every part of 10g) primarily of following bulk drugs: 11.5 parts, Poria, Herba Clinacanthi Nutantis 12.5 parts, 4.5 parts, Natrii Sulfas, Fructus Toosendan 10.5 parts, Radix Anemones Rivularis 10 parts, the Radix Paeoniae Alba 11.5 parts, Herba clerodendranthi spicati 11.5 parts, Herba humuli scandentis 11 parts, Herba Dendrobii 12.5 parts, Fructus Aurantii 10.5 parts, Radix Pseudostellariae 12.5 parts, Caulis et folium pavettae hongkongensis 13 parts, Folium Pyrrosiae 5 parts.Above-mentioned a kind of preparation method for the treatment of the Chinese medicine composition tablet of cholelithiasis is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, be cut into silk or section after cleaning, add rice wine and infiltrate 14 minutes, slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 32 minutes, take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add the water soaking 16 minutes of boiled crude drug quality 6 times, intense fire is heated to boiling, turns little fire and decocts 29 minutes, collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug is pulverized together with Natrii Sulfas with step (1) (2) (3), is squeezed into tablet dosage form, obtains tablet.
test example 1a kind of clinical practice for the treatment of the Chinese medicine composition (embodiment 5) of cholelithiasis of gained of the present invention:
Choose crowd: in October, 2013 in December ,-2014, according to medical case history, have patient 384 example of cholelithiasis three hospitals' screenings, wherein male patient 185 example, female patient 199 example, age 22-66 year, 40.6 ± 1.2 years old mean age.The diagnostic criteria of reference literature: clinical manifestation is right rib, upper right abdomen pain or distending pain, and anorexia greasy food, some patients has biliary colic, and minority with heating, and is made a definite diagnosis through ultrasound diagnosis.
Before test, patient is divided into two groups at random, experimental group 252 example and matched group 132 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, each 3-4 sheet, one day twice, warmly takes, and within ten days, is a course for the treatment of; Matched group takes other conventional medicines (XIAOYAN LIDAN PIAN, JINDAN PIAN, DANKANG JIAONANG or PAISHI KELI etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: symptom and sign disappear completely, and B ultrasonic display calculus is got rid of clean; (2) effective: symptom and sign disappear, B ultrasonic display calculus part is got rid of; (3) invalid: symptom and sign still exist, B ultrasonic display calculus is not discharged.
Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, products obtained therefrom treatment time of the present invention is short, instant effect, effectively can reduce patient suffering, and after treating three courses for the treatment of, the healing patient of experimental group is 154 examples, cure rate is 61.1%, and effective patient is 92 examples, and effective percentage is 36.5%, total effective rate is 97.6%, and the cure rate of matched group is 44.7%, and effective percentage is 34.1%, total effective rate 78.8%, significantly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The Chinese medicine used in the present invention, Poria can promoting diuresis to eliminate damp pathogen, and Herba Clinacanthi Nutantis and Herba clerodendranthi spicati can clearing away heat-damp and promoting diuresis, Natrii Sulfas can purge heat and moisturize, and Fructus Toosendan can liver heat removing pathogenic fire reducing, and Radix Anemones Rivularis and Herba humuli scandentis can heat-clearing and toxic substances removing, the Radix Paeoniae Alba can easing the affected liver to relieve pain, and Herba Dendrobii can clearing away heat and nourishing YIN, the feasible stagnant relieving distension of Fructus Aurantii, Radix Pseudostellariae can mend strengthening spleen and lung, and Caulis et folium pavettae hongkongensis can clearing away heat to improve acuity of vision, and Folium Pyrrosiae can relieving stranguria by diuresis, multiple medical material synergism, effect of common performance heat-clearing and toxic substances removing, easing the affected liver to relieve pain, effectively eliminates uncomfortable disease, discharges cholelithiasis.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a Chinese medicine composition for cholelithiasis, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Poria 8-15; Herba Clinacanthi Nutantis 10-15; Natrii Sulfas 3-6; Fructus Toosendan 9-12; Radix Anemones Rivularis 8-12; Radix Paeoniae Alba 9-14; Herba clerodendranthi spicati 10-13; Herba humuli scandentis 9-13; Herba Dendrobii 11-14; Fructus Aurantii 8-13; Radix Pseudostellariae 10-15; Caulis et folium pavettae hongkongensis 11-15; Folium Pyrrosiae 3-7.
2. a kind of Chinese medicine composition for the treatment of cholelithiasis as claimed in claim 1, is characterized in that, Poria 10-13; Herba Clinacanthi Nutantis 11-14; Natrii Sulfas 4-5; Fructus Toosendan 10-11; Radix Anemones Rivularis 9-11; Radix Paeoniae Alba 11-12; Herba clerodendranthi spicati 11-12; Herba humuli scandentis 10-12; Herba Dendrobii 12-13; Fructus Aurantii 9-12; Radix Pseudostellariae 11-14; Caulis et folium pavettae hongkongensis 12-14; Folium Pyrrosiae 4-6(is preferably: Poria 11.5; Herba Clinacanthi Nutantis 12.5; Natrii Sulfas 4.5; Fructus Toosendan 10.5; Radix Anemones Rivularis 10; The Radix Paeoniae Alba 11.5; Herba clerodendranthi spicati 11.5; Herba humuli scandentis 11; Herba Dendrobii 12.5; Fructus Aurantii 10.5; Radix Pseudostellariae 12.5; Caulis et folium pavettae hongkongensis 13; Folium Pyrrosiae 5).
3. a kind of Chinese medicine composition for the treatment of cholelithiasis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts, collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug is pulverized together with Natrii Sulfas with step (1) (2) (3), is squeezed into tablet dosage form, obtains tablet.
4. a kind of preparation method for the treatment of the Chinese medicine composition tablet of cholelithiasis as claimed in claim 3, is characterized in that, step (4) turn little fire decoct 20-38 minute (preferred: to turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes).
5. a kind of Chinese medicine composition for the treatment of cholelithiasis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes), collecting by filtration filtrate;
(5) spray drying step (4) gained filtrate, made crude drug pulverizes and sieves together with Natrii Sulfas with step (1) (2) (3), is packed in capsule, obtains capsule.
6. a kind of preparation method for the treatment of the Chinese medicinal composition capsules agent of cholelithiasis as claimed in claim 5, is characterized in that, it is (preferred: to pulverize 80-100 mesh sieve that step (5) pulverized 60-120 mesh sieve; Be more preferably: pulverized 90 mesh sieves).
7. a kind of Chinese medicine composition for the treatment of cholelithiasis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes), collecting by filtration filtrate;
(5) heat concentration step (4) gained filtrate to paste, step (1) (2) (3) made crude drug and Natrii Sulfas are pulverized, mixes with paste, smash after oven dry, then add adjuvant, granulation, granulate, drying, pack and obtain granule.
8. a kind of preparation method for the treatment of the Chinese medicinal composition granules of cholelithiasis as claimed in claim 7, is characterized in that, the 4-7 that step (4) amount of water is boiled crude drug quality doubly (preferred: amount of water be the 5-6 of made crude drug quality doubly; Be more preferably: amount of water is 5.5 times of boiled crude drug quality).
9. a kind of Chinese medicine composition for the treatment of cholelithiasis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Oleum Sesami and be placed in heating in iron pan, after oil is smoldered, add clean Fructus Toosendan and Fructus Aurantii, explode to its colour changed into yellow, take out drop oil to the greatest extent, dry in the air cool;
(2) get Herba Clinacanthi Nutantis, Herba clerodendranthi spicati, Herba humuli scandentis, Caulis et folium pavettae hongkongensis and Folium Pyrrosiae removing impurity, after cleaning, be cut into silk or section, add rice wine and infiltrate 10-18 minute (preferably: infiltrate 12-16 minute; Be more preferably: infiltrate 14 minutes), slow fire dries, and repeats once, takes out, dries in the air cool;
(3) get Radix Pseudostellariae and pick up clean impurity, spray water moistening, hit crust, Steam by water bath 25-39 minute (preferred: Steam by water bath 29-35 minute; Be more preferably: Steam by water bath 32 minutes), take out and cut sheet, be placed in frying pan, drench into crystal sugar water, take out after fried dry, dry in the air cool;
(4) Poria, Radix Anemones Rivularis, the Radix Paeoniae Alba and Herba Dendrobii are cleaned, add boiled crude drug quality 5-7 water doubly (preferred: the water adding boiled crude drug quality 6 times) and soak 16 minutes, intense fire is heated to boiling, turns little fire and decocts 20-38 minute (preferably: turn little fire and decoct 25-33 minute; Be more preferably: turn little fire and decoct 29 minutes), collecting by filtration filtrate;
(5) step (1) (2) (3) made crude drug is pulverized and sieved together with Natrii Sulfas, be added in step (4) gained filtrate, stir, obtain decoction.
10. a kind of preparation method for the treatment of the Chinese medicine composition decoction of cholelithiasis as claimed in claim 9, is characterized in that, it is (preferred: to pulverize 120-140 mesh sieve that step (5) pulverized 100-160 mesh sieve; Be more preferably: pulverized 130 mesh sieves).
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| CN106511454A (en) * | 2016-12-16 | 2017-03-22 | 王建英 | Hairball-elimination and antilithic pill |
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| CN103816311A (en) * | 2014-01-24 | 2014-05-28 | 何成元 | Traditional Chinese medicinal composition for treating cholelithiasis |
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| CN103705840A (en) * | 2012-10-09 | 2014-04-09 | 黑龙江省中医研究院 | Medicinal composition for treating acute and chronic cholecystitis, and cholelithiasis, and preparation method thereof |
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