CN105012401A - Preparation for treating leucoderma and preparation method - Google Patents

Preparation for treating leucoderma and preparation method Download PDF

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CN105012401A
CN105012401A CN201510485530.4A CN201510485530A CN105012401A CN 105012401 A CN105012401 A CN 105012401A CN 201510485530 A CN201510485530 A CN 201510485530A CN 105012401 A CN105012401 A CN 105012401A
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parts
preparation
leukodermic
radix
water
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李荣华
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李荣华
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Abstract

The invention discloses a preparation for treating leucoderma. The preparation is mainly prepared from, by mass, 8 parts to 14 parts of notopterygium, 10 parts to 13 parts of all-grass of delavay pararuellia, 12 parts to 17 parts of glossy privet fruit, 9 parts to 15 parts of mountain fortune eupatorium herbs, 7 parts to 13 parts of piper cubeba, 8 parts to 15 parts of caltrop flowers, 11 parts to 16 parts of cynanchum paniculatum, 7 parts to 12 parts of nemipterus aurorus, 9 parts to 14 parts of cunninghamia lanceolata, 10 parts to 15 parts of tropaeolum majus, 7 parts to 10 parts of stiff silkworms, 9 parts to 12 parts of porana racemosa roxb and 8 parts to 13 parts of English walnut exocarp. The preparation is prepared according to multiple years of clinical practice, and has the functions of expelling the wind, promoting blood circulation and tonifying livers and kidneys, and is remarkable in curative effect.

Description

The leukodermic preparation of a kind for the treatment of and preparation method
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the leukodermic preparation of a kind for the treatment of and preparation method.
Background technology
Vitiligo is that a kind of common posteriority limit office property or general property skin pigment depigmentation are sick.Melanocyte function due to skin disappears and causes, but mechanism is not clear.The each position of whole body can occur, and is common in and refers to the back of the body, wrist, forearm, face, neck and surrounding genital etc.Female genitalia also can occur, and young women is in the majority.Men and women's sickness rate, without marked difference, all can be fallen ill from neonatal to old old man, and morbidity in 6 ~ 25 years old reaches peak.Be point-like or lamellar depigmentation macule during onset, a slice or several pieces, because of melanin complete depigmentation, in pale, demarcate not fully aware of with normal skin, skin lesion develops expansion gradually, the complete depigmentation of melanin, demarcate clear with normal skin, be creamy white or porcelain white, differ in size, shape is indefinite, can be circle, oval, ground figure etc.Number not etc., from single skin lesion to multiple white macula, all can not fall ill by any position of whole body.
Publication No. CN 104042866 A(application number 201310097262.X) Chinese patent literature disclose one and treat leukodermic medicine, it is characterized in that: Herba Schizonepetae, Radix Saposhnikoviae, Periostracum Cicadae, linum, Radix Sophorae Flavescentis, Rhizoma Atractylodis, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, cattle wife, Caulis Akebiae, the Radix Rehmanniae, Fructus Atriplicis Sibiricae, Fructus Psoraleae, Radix Paeoniae Alba compound form first group of medicine; Herba Schizonepetae, Radix Saposhnikoviae, Periostracum Cicadae, linum, Radix Sophorae Flavescentis, Rhizoma Atractylodis, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Fructus Arctii, Caulis Akebiae, the Radix Rehmanniae, Radix Salviae Miltiorrhizae, Caulis Spatholobi, Caulis Polygoni Multiflori compound form second group of medicine.Publication No. CN 104474298 A(application number 201410669806.X) Chinese patent literature disclose one and treat leukodermic Chinese medicine, it is Cortex Dictamni 20-50, Rhizoma Gastrodiae 15-30, Flos Carthami 5-15, Fructus Psoraleae 20-40, Radix Salviae Miltiorrhizae 5-15, Radix Angelicae Dahuricae 10-20, Flos Lonicerae 10-20, Fructus Mume 5-15, Radix Astragali 10-20, Borneolum Syntheticum 5-10, Scorpio 2-5, Fructus Lycii 5-15, Radix Saposhnikoviae 5-10 make.Publication No. CN 104721367 A(application number 201510096733.4) Chinese patent literature disclose one and be used for the treatment of leukodermic Chinese medicine, be prepared from by the crude drug of following weight: Fructus Psoraleae 10 parts, Radix Polygoni Multiflori Preparata 8 parts, 8 parts, the Radix Rehmanniae, Rhizoma Chuanxiong 6 parts.
Because leukodermic pathogenesis is not yet clear and definite, be used for the treatment of leukodermic medicine on the market, effect is very different, and some side effect is comparatively large, and then effect is not remarkable for some, therefore needs the Chinese medicine formula developing a kind of determined curative effect, safety has no side effect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide the wide leukodermic preparation for the treatment of of a kind of Be very effective, the use safety suitability and preparation method.
Technical scheme of the present invention is:
The leukodermic preparation of a kind for the treatment of, is prepared from primarily of following bulk drugs, is mass parts: Rhizoma Et Radix Notopterygii 8-14; Herb Pararuelliae delavayanae 10-13; Fructus Ligustri Lucidi 12-17; Mountain Herba Eupatorii 9-15; Fructus Litseae 7-13; Flos tribuli 8-15; Radix Cynanchi Paniculati 11-16; Gold line 7-12; China fir tower 9-14; Herba Tropaeoli 10-15; Bombyx Batryticatus 7-10; Radix seu Herba Poranae Racemosae 9-12; Exocarpium Juglandis Immaturus 8-13.
Preferred version is, Rhizoma Et Radix Notopterygii 10-12; Herb Pararuelliae delavayanae 11-12; Fructus Ligustri Lucidi 14-15; Mountain Herba Eupatorii 11-13; Fructus Litseae 9-11; Flos tribuli 10-13; Radix Cynanchi Paniculati 12-15; Gold line 9-10; China fir tower 11-12; Herba Tropaeoli 11-14; Bombyx Batryticatus 8-9; Radix seu Herba Poranae Racemosae 10-11; Exocarpium Juglandis Immaturus 9-12.
More preferably, Rhizoma Et Radix Notopterygii 11; Herb Pararuelliae delavayanae 11.5; Fructus Ligustri Lucidi 14.5; Mountain Herba Eupatorii 12; Fructus Litseae 10; Flos tribuli 11.5; Radix Cynanchi Paniculati 13.5; Gold line 9.5; China fir tower 11.5; Herba Tropaeoli 12.5; Bombyx Batryticatus 8.5; Radix seu Herba Poranae Racemosae 10.5; Exocarpium Juglandis Immaturus 10.5.
Described a kind of preparation method curing leukodermic preparation, step is as follows:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, it is (preferred: to add decocting in water 22-28 minute to add decocting in water 20-30 minute; Be more preferably: add decocting in water 25 minutes), take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, add refined honey water and mix thoroughly, be placed in steamer, Steam by water bath 10-24 minute (preferred: Steam by water bath 14-20 minute; Be more preferably: Steam by water bath 17 minutes), take out and jointly put into hot pot with Testa Tritici, slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverize and sieve, make medicated powder together with step (1) (2) made crude drug;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, decoct with water to boiling, continue 8 minutes, then turn little fire decoction, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder, stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
Described a kind of preparation method curing leukodermic preparation, the amount that step (2) adds refined honey water is the 0.3-0.5 of Bombyx Batryticatus quality doubly (preferred: the amount adding refined honey water is 0.4 times of Bombyx Batryticatus quality).
Described a kind of preparation method curing leukodermic preparation, step (3) amount of drenching into rice wine is the 0.2-0.4 of crude drug quality doubly (preferred: the amount of drenching into rice wine is 0.3 times of crude drug quality).
Described a kind of preparation method curing leukodermic preparation, it is (preferred: to pulverize 80-100 mesh sieve that step (3) pulverized 60-120 mesh sieve; Be more preferably: pulverized 90 mesh sieves).
Described a kind of preparation method curing leukodermic preparation, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
Described a kind of preparation method curing leukodermic preparation, step (4) turns little fire and decocts 18-34 minute (preferably: turn little fire and decoct 22-30 minute; Be more preferably: turn little fire and decoct 26 minutes).
Described a kind of preparation method curing leukodermic preparation, the mass ratio of the rice vinegar that step (5) adds and medicated powder is 1:2.
One provided by the invention cures leukodermic pharmaceutical formulation science, and preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, clinical effectiveness is remarkable, and cure rate is high, and total effective rate reaches 97.7%;
2, this formula is summed up through clinical practice for many years and is formed, and has the effect of dispeling the wind with blood, liver and kidney tonifying;
3, Chinese crude drug selected by the present invention, safety has no side effect, can life-time service, can regulate patient body function.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the leukodermic preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 8 parts, Herb Pararuelliae delavayanae 10 parts, Fructus Ligustri Lucidi 12 parts, mountain Herba Eupatorii 9 parts, Fructus Litseae 7 parts, Flos tribuli 8 parts, Radix Cynanchi Paniculati 11 parts, gold line 7 parts, 9 parts, China fir tower, Herba Tropaeoli 10 parts, Bombyx Batryticatus 7 parts, Radix seu Herba Poranae Racemosae 9 parts, Exocarpium Juglandis Immaturus 8 parts.Above-mentioned a kind of preparation method curing leukodermic preparation is:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, add decocting in water 20 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, the refined honey water adding Bombyx Batryticatus quality 0.3 times is mixed thoroughly, is placed in steamer, Steam by water bath 10 minutes, takes out and jointly puts into hot pot with Testa Tritici, and slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench the rice wine into crude drug quality 0.2 times, stir-fry micro-Jiao to surface, takes out, pulverize 60 mesh sieves together with step (1) (2) made crude drug, make medicated powder;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, add the soak by water of boiled crude drug quality 5 times to boiling, continue 8 minutes, turn little fire again to decoct 18 minutes, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder (mass ratio of rice vinegar and medicated powder is 1:2), stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
embodiment 2the leukodermic preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 14 parts, Herb Pararuelliae delavayanae 13 parts, Fructus Ligustri Lucidi 17 parts, mountain Herba Eupatorii 15 parts, Fructus Litseae 13 parts, Flos tribuli 15 parts, Radix Cynanchi Paniculati 16 parts, gold line 12 parts, 14 parts, China fir tower, Herba Tropaeoli 15 parts, Bombyx Batryticatus 10 parts, Radix seu Herba Poranae Racemosae 12 parts, Exocarpium Juglandis Immaturus 13 parts.Above-mentioned a kind of preparation method curing leukodermic preparation is:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, add decocting in water 30 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, the refined honey water adding Bombyx Batryticatus quality 0.5 times is mixed thoroughly, is placed in steamer, Steam by water bath 24 minutes, takes out and jointly puts into hot pot with Testa Tritici, and slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench the rice wine into crude drug quality 0.4 times, stir-fry micro-Jiao to surface, takes out, pulverize 120 mesh sieves together with step (1) (2) made crude drug, make medicated powder;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, add the soak by water of boiled crude drug quality 8 times to boiling, continue 8 minutes, turn little fire again to decoct 34 minutes, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder (mass ratio of rice vinegar and medicated powder is 1:2), stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
Model case: xxx, male, 23 years old.Main suit: there is the white macula of palm size at back, has diffusion tendency, superficial, distributes in the form of sheets, boundary clear, with dizziness and tinnitus, weak drowsiness symptom, on inspection, patient's light red tongue tongue is few, and thready pulse without strength is diagnosed as vitiligo.
Use this example gained external preparation, one day twice, be applied in affected part, it within 25 days, is a course for the treatment of, after patient uses a course for the treatment of, uncomfortable disease obviously alleviates, and white macula starts to disappear, after adhering to three courses for the treatment of of use, white macula all disappears, and all diseases disappear entirely, and patient's self-confidence strengthens, follow up a case by regular visits in 1 year, the state of an illness is without recurrence.
embodiment 3the leukodermic preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 10 parts, Herb Pararuelliae delavayanae 11 parts, Fructus Ligustri Lucidi 14 parts, mountain Herba Eupatorii 11 parts, Fructus Litseae 9 parts, Flos tribuli 10 parts, Radix Cynanchi Paniculati 12 parts, gold line 9 parts, 11 parts, China fir tower, Herba Tropaeoli 11 parts, Bombyx Batryticatus 8 parts, Radix seu Herba Poranae Racemosae 10 parts, Exocarpium Juglandis Immaturus 9 parts.Above-mentioned a kind of preparation method curing leukodermic preparation is:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, add decocting in water 22 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, the refined honey water adding Bombyx Batryticatus quality 0.3 times is mixed thoroughly, is placed in steamer, Steam by water bath 14 minutes, takes out and jointly puts into hot pot with Testa Tritici, and slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench the rice wine into crude drug quality 0.2 times, stir-fry micro-Jiao to surface, takes out, pulverize 80 mesh sieves together with step (1) (2) made crude drug, make medicated powder;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, add the soak by water of boiled crude drug quality 6 times to boiling, continue 8 minutes, turn little fire again to decoct 22 minutes, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder (mass ratio of rice vinegar and medicated powder is 1:2), stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
embodiment 4the leukodermic preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 12 parts, Herb Pararuelliae delavayanae 12 parts, Fructus Ligustri Lucidi 15 parts, mountain Herba Eupatorii 13 parts, Fructus Litseae 11 parts, Flos tribuli 13 parts, Radix Cynanchi Paniculati 15 parts, gold line 10 parts, 12 parts, China fir tower, Herba Tropaeoli 14 parts, Bombyx Batryticatus 9 parts, Radix seu Herba Poranae Racemosae 11 parts, Exocarpium Juglandis Immaturus 12 parts.Above-mentioned a kind of preparation method curing leukodermic preparation is:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, add decocting in water 28 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, the refined honey water adding Bombyx Batryticatus quality 0.5 times is mixed thoroughly, is placed in steamer, Steam by water bath 20 minutes, takes out and jointly puts into hot pot with Testa Tritici, and slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench the rice wine into crude drug quality 0.4 times, stir-fry micro-Jiao to surface, takes out, pulverize 100 mesh sieves together with step (1) (2) made crude drug, make medicated powder;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, add the soak by water of boiled crude drug quality 7 times to boiling, continue 8 minutes, turn little fire again to decoct 30 minutes, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder (mass ratio of rice vinegar and medicated powder is 1:2), stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
Model case: xxx, women, 36 years old.Medical history: patient, before three months, finds that face and cervical region engender fritter white macula, starts not take notice of, rear state of an illness diffusion is serious, white macula increases, increased number, and in speckle, hair bleaches, affect attractive in appearance, patient heart is irritated, and sleep quality is poor, is vitiligo to hospital diagnosis, after taking medicine, the state of an illness is not thoroughly alleviated.
After listen this example of people's recommendation gained external preparation, one day twice, be applied in affected part, it within 25 days, is a course for the treatment of, after patient uses a course for the treatment of, the state of an illness obviously alleviates, and patient mental's state takes a turn for the better gradually, after continuing two courses for the treatment of of use, white macula is vanished from sight substantially, and the colour of skin recovers normal, and patient fully recovers, follow up a case by regular visits in half a year, the state of an illness does not recur again.
embodiment 5the leukodermic preparation of a kind for the treatment of, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Et Radix Notopterygii 11 parts, Herb Pararuelliae delavayanae 11.5 parts, Fructus Ligustri Lucidi 14.5 parts, mountain Herba Eupatorii 12 parts, Fructus Litseae 10 parts, Flos tribuli 11.5 parts, Radix Cynanchi Paniculati 13.5 parts, gold line 9.5 parts, 11.5 parts, China fir tower, Herba Tropaeoli 12.5 parts, Bombyx Batryticatus 8.5 parts, Radix seu Herba Poranae Racemosae 10.5 parts, Exocarpium Juglandis Immaturus 10.5 parts.Above-mentioned a kind of preparation method curing leukodermic preparation is:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, add decocting in water 25 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, the refined honey water adding Bombyx Batryticatus quality 0.4 times is mixed thoroughly, is placed in steamer, Steam by water bath 17 minutes, takes out and jointly puts into hot pot with Testa Tritici, and slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench the rice wine into crude drug quality 0.3 times, stir-fry micro-Jiao to surface, takes out, pulverize 90 mesh sieves together with step (1) (2) made crude drug, make medicated powder;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, add the soak by water of boiled crude drug quality 6.5 times to boiling, continue 8 minutes, turn little fire again to decoct 26 minutes, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder (mass ratio of rice vinegar and medicated powder is 1:2), stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Et Radix Notopterygii: warm in nature, acrid in the mouth, hardship.Have that cold expelling dispels the wind, the function of removing damp and stopping pain.For anemofrigid cold, headache body pain.The pungent temperature of this product, gas is male and fall apart, delivers power strong, the heresy of main fall apart Taiyang channel ailment said due to cold or exposure and cold-damp, has cold expelling to dispel the wind, the merit of removing dampness to relieve pain.
Herb Pararuelliae delavayanae: base is former: be the herb of the little luxuriant Herba Rostellulariae of acanthaceous plant happiness oak.Summer, autumn gather, and chopping, dries.Nature and flavor: " Yunnan Chinese herbal medicine ": " sweet light, flat." function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control pneumonia, tonsillitis, parotitis, scrofula, abscess sore, fracture, traumatic infection.
Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, clear empty improving eyesight.Cure mainly Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.Compatibility and incompatibility of drugs: Deficiency and coldness of spleen and stomach is had loose bowels and the careful clothes of yang deficiency person.
Mountain Herba Eupatorii: base is former: be the herb of the single Ye Peilan of feverfew.Nature and flavor: acrid in the mouth; Bitter; Property is put down.Function cures mainly: drive away summer heat and deliver; Removing dampness for regulating stomach; Vital energy regualting and blood circulation-promoting; Removing toxic substances.Main Sunstroke by every means wets; Fever and headache; The vexed abdominal distention of born of the same parents; Dyspepsia; Gastroenteritis; Sense stomach; Cough; Pharyngolaryngitis; Tonsillitis; Menoxenia; Traumatic injury; Carbuncle; Venom.
Fructus Litseae: base is former: be the fruit of Piperaceae plant Fructus Litseae.Nature and flavor: pungent; Temperature.Gui Jing: spleen; Kidney; Stomach; Urinary bladder channel.Function cures mainly: warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Warming the kidney.Main cold syndrome of the stomach vomiting; Distension and fullness in the abdomen cold type of pain; Increased borborygmus and diarrhea; Colic of cold type is suffered from abdominal pain; Cold-damp dribbling urination is muddy.
Flos tribuli: base is former: be the flower of zygophyllaceae plant Fructus Tribuli.Nature and flavor: pungent; Temperature.Gui Jing: Liver Channel.Function cures mainly: dispel the wind and blood.Main vitiligo.
Radix Cynanchi Paniculati: base is former: be the dry root welding technology of Luo Mo section plant Radix Cynanchi Paniculati.Nature and flavor with return through: pungent, temperature.Return liver, stomach warp.Function with cure mainly: dispel the wind, removing dampness, pain relieving, antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, falls and flutters the pain of injury, rubella, eczema.
Gold line: base is former: be the herb of gentianaceae plant Hong Kong Tripterospermum affine.Nature and flavor: sweet; Pungent; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.Main cough due to lung-heat; Spitting of blood; Lung abscess; Urine leaching is puckery; Acute mastitis; Furuncle furuncle and phyma; Traumatic hemorrhage.
Shan Ta: base is former: be the cone of Taxodiaceae Cunninghamia plant Lignum seu Ramulus Cunninghamiae Lanceolatae.The property of medicine: pungent, tepor.Function cures mainly: warming the kidney to invigorate YANG, and parasite killing detoxifies, mind calming, cough-relieving.Cure mainly seminal emission, sexual impotence, vitiligo, acute mastitis, cardiopalmus, cough.
Herba Tropaeoli: base is former: be the herb of Tropaeolaceae plant nasturtium.Nature and flavor: acrid in the mouth; Acid; Cool in nature.Gui Jing: the heart; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main conjunctival congestion and swelling pain; Furuncle; Spit blood; Spitting of blood.
Bombyx Batryticatus: have another name called Bombyx Batryticatus, the larva belonging to animal bombyx mori for Bombycidae silkworm infects muscardine and ossified Scorpio.The property of medicine: this product is slightly cylindrical, how bending shrinkage, surperficial lark, matter is hard and crisp, frangibility, acrid in the mouth, salty, and property is put down.Composition: Bombyx Batryticatus containing protein, oxamidic acid., and contains lysine, leucine, aspartic acid etc. 17 seed amino acid.According to modern pharmacological research find, this medical instrument have expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat, convulsion, hypoglycemic effect, for apoplexy, migraine and general headache, laryngopharynx swelling and pain, rubella etc.
Radix seu Herba Poranae Racemosae: base is former: be root or the herb of dicotyledon scammonia section plant buccae rattan.Nature and flavor: temperature; Pungent.Gui Jing: lung meridian.Function cures mainly: induce sweat; Circulation of qi promoting; Invigorate blood circulation; Removing toxic substances.Main cold; Dyspepsia abdominal distention; Innominate toxic swelling.
Exocarpium Juglandis Immaturus: base is former: be the outer peel of the immature fruit of juglandaceae plant Semen Juglandis.Nature and flavor: bitter; Puckery; Property is put down.Gui Jing: liver; Spleen; Stomach warp.Function cures mainly: pain relieving; Cough-relieving; Antidiarrheal; Removing toxic substances; Parasite killing.Main epigastric pain; Dysmenorrhea; Chronic cough; To have loose bowels chronic dysentery; Carbuncle sore tumefacting virus; Stubborn dermatitis; Tinea alba; Vitiligo.
test example 1gained one of the present invention cures the clinical practice of leukodermic preparation (embodiment 5):
Choose crowd: in February, 2014 in December ,-2014, choose patients with vitiligo 290 example, age 15-65 year, 34.2 ± 1.8 years old mean age, the course of disease 3 months-15 years, wherein male patient 148 example, female patient 142 example.Inclusion criteria: 1. all patients are all diagnosed as vitiligo; 2. without polychroism; 3. defer to the principle of voluntariness; 4. regularly can carry out further consultation inspection.Get rid of anemia of pregnant woman, women breast-feeding their children, or have the organic systemic disease patient of severe cardiac Liver and kidney.
Before test, patient is divided into two groups at random, experimental group 176 example and matched group 114 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, one day twice, is applied in affected part, within 25 days, is a course for the treatment of; Matched group uses other conventional medicines (vifiligo pill, Wei Alu, disappear simple Ointment etc.).During medication, Continuous Observation is carried out to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: white macula all disappears, and recovers normal skin tone.(2) effective: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion Mian Ji≤50%.(3) take a turn for the better: white macula partial remission or reduce.(4) invalid: the regeneration of white macula non-pigment or expanded range.
Clinical effectiveness: after the medication of three courses for the treatment of, the therapeutic outcome of two groups is as follows:
The healing patient of experimental group is 115 examples (65.3%), effective patient is 35 examples (19.9%), improvement patient is 22 examples (12.5%), and total effective rate is 97.7%, and the patient that matched group is cured is 60 examples (52.6%), effective patient is 22 examples (19.3%), the patient taken a turn for the better is 13 examples (11.4%), and total effective rate 83.3%, is starkly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
Follow up a case by regular visits to two groups of patients after 1 year, experimental group only has an example recurrence, and matched group recurrence number of cases reaches 13 examples, illustrates that products obtained therefrom of the present invention thoroughly can cure vitiligo, prevents from again recurring.
The Chinese medicine used in the present invention, Rhizoma Et Radix Notopterygii cold expelling dispels the wind, Herb Pararuelliae delavayanae, gold line heat-clearing and toxic substances removing, Fructus Ligustri Lucidi liver and kidney tonifying, mountain Herba Eupatorii vital energy regualting and blood circulation-promoting, Fructus Litseae promoting the circulation of QI to relieve pain, Flos tribuli dispels the wind and blood, and Radix Cynanchi Paniculati dispels the wind removing dampness, China fir tower warming the kidney to invigorate YANG, Herba Tropaeoli cooling blood for hemostasis, Bombyx Batryticatus is expellingged wind and relieving convulsion, Radix seu Herba Poranae Racemosae promoting flow of QI and blood, Exocarpium Juglandis Immaturus removing toxic substances pain relieving, multiple medical material synergism, plays the effect of dispeling the wind with blood, liver and kidney tonifying altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. cure a leukodermic preparation, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Rhizoma Et Radix Notopterygii 8-14; Herb Pararuelliae delavayanae 10-13; Fructus Ligustri Lucidi 12-17; Mountain Herba Eupatorii 9-15; Fructus Litseae 7-13; Flos tribuli 8-15; Radix Cynanchi Paniculati 11-16; Gold line 7-12; China fir tower 9-14; Herba Tropaeoli 10-15; Bombyx Batryticatus 7-10; Radix seu Herba Poranae Racemosae 9-12; Exocarpium Juglandis Immaturus 8-13.
2. the leukodermic preparation of a kind for the treatment of as claimed in claim 1, is characterized in that, Rhizoma Et Radix Notopterygii 10-12; Herb Pararuelliae delavayanae 11-12; Fructus Ligustri Lucidi 14-15; Mountain Herba Eupatorii 11-13; Fructus Litseae 9-11; Flos tribuli 10-13; Radix Cynanchi Paniculati 12-15; Gold line 9-10; China fir tower 11-12; Herba Tropaeoli 11-14; Bombyx Batryticatus 8-9; Radix seu Herba Poranae Racemosae 10-11; Exocarpium Juglandis Immaturus 9-12.
3. the leukodermic preparation of a kind for the treatment of as claimed in claim 1, is characterized in that, Rhizoma Et Radix Notopterygii 11; Herb Pararuelliae delavayanae 11.5; Fructus Ligustri Lucidi 14.5; Mountain Herba Eupatorii 12; Fructus Litseae 10; Flos tribuli 11.5; Radix Cynanchi Paniculati 13.5; Gold line 9.5; China fir tower 11.5; Herba Tropaeoli 12.5; Bombyx Batryticatus 8.5; Radix seu Herba Poranae Racemosae 10.5; Exocarpium Juglandis Immaturus 10.5.
4. a kind of preparation method curing leukodermic preparation as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Fructus Ligustri Lucidi, Fructus Litseae and Shan Ta and remove impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, it is (preferred: to add decocting in water 22-28 minute to add decocting in water 20-30 minute; Be more preferably: add decocting in water 25 minutes), take out, removing Semen sojae atricolor, dry;
(2) get Bombyx Batryticatus and clean remove impurity, add refined honey water and mix thoroughly, be placed in steamer, Steam by water bath 10-24 minute (preferred: Steam by water bath 14-20 minute; Be more preferably: Steam by water bath 17 minutes), take out and jointly put into hot pot with Testa Tritici, slow fire stir-fries to surface and turns yellow, and take out, sieve removes Testa Tritici, cools;
(3) get Rhizoma Et Radix Notopterygii, Radix Cynanchi Paniculati, Radix seu Herba Poranae Racemosae and Exocarpium Juglandis Immaturus and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverize and sieve, make medicated powder together with step (1) (2) made crude drug;
(4) Herb Pararuelliae delavayanae, mountain Herba Eupatorii, Flos tribuli, gold line and Herba Tropaeoli remove impurity are cleaned, be placed in marmite, decoct with water to boiling, continue 8 minutes, then turn little fire decoction, filtering and collecting filter liquid, heating concentrated filtrate is to clear paste;
(5) mixed with rice vinegar by step (3) made medicated powder, stir to paste, then add step (4) gained clear paste, mix homogeneously, obtains external preparation.
5. a kind of preparation method curing leukodermic preparation as claimed in claim 4, is characterized in that, the amount that step (2) adds refined honey water is the 0.3-0.5 of Bombyx Batryticatus quality doubly (preferred: the amount adding refined honey water is 0.4 times of Bombyx Batryticatus quality).
6. a kind of preparation method curing leukodermic preparation as claimed in claim 4, is characterized in that, step (3) amount of drenching into rice wine is the 0.2-0.4 of crude drug quality doubly (preferred: the amount of drenching into rice wine is 0.3 times of crude drug quality).
7. a kind of preparation method curing leukodermic preparation as claimed in claim 4, is characterized in that, it is (preferred: to pulverize 80-100 mesh sieve that step (3) pulverized 60-120 mesh sieve; Be more preferably: pulverized 90 mesh sieves).
8. a kind of preparation method curing leukodermic preparation as claimed in claim 4, is characterized in that, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
9. a kind of preparation method curing leukodermic preparation as claimed in claim 4, is characterized in that, step (4) turns little fire and decocts 18-34 minute (preferably: turn little fire and decoct 22-30 minute; Be more preferably: turn little fire and decoct 26 minutes).
10. a kind of preparation method curing leukodermic preparation as claimed in claim 4, is characterized in that, the mass ratio of the rice vinegar that step (5) adds and medicated powder is 1:2.
CN201510485530.4A 2015-08-11 2015-08-11 Preparation for treating leucoderma and preparation method Pending CN105012401A (en)

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