CN105012419A - External-applying washing agent for treating leucoderma and preparing method thereof - Google Patents
External-applying washing agent for treating leucoderma and preparing method thereof Download PDFInfo
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Abstract
The invention discloses an external-applying washing agent for treating leucoderma. The external-applying washing agent is prepared by, by mass, 10-15 parts of artemisia anomala, 8-13 parts of roots of gourian clematis, 6-14 parts of fir towers, 9-13 parts of lithospermum, 7-12 parts of elsholtziae, 10-14 parts of caltrop flowers, 8-15 parts of maesa japonica, 11-16 parts of glossy privet fruits, 7-14 parts of herba siegesbeckiae, 10-17 parts of cynanchum paniculatum, 8-14 parts of common adenostema herbs, 9-15 parts of fructus psoraleae, 7-13 parts of huangjinxian and 8-12 parts of fennelflowers. The external-applying washing agent is prepared after summarization of clinical practice many years, has the effects of removing freckles, tonifying liver and tonifying kidney and is effective in treatment.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat leukodermic outer lotion and preparation method.
Background technology
Vitiligo is a kind of common multiple pigmented dermatosis.This disease forms white macula for feature with local or general property depigmentation, is a kind of acquired limitation or general property depigmentation of skin, and be the common skin diseases of an impact beauty treatment, easily diagnose, treatment is difficult.Men and women's sickness rate, without marked difference, all can be fallen ill from neonatal to old old man, and morbidity in 6 ~ 25 years old reaches peak.Be point-like or lamellar depigmentation macule during onset, a slice or several pieces, because of melanin complete depigmentation, in pale, demarcate not fully aware of with normal skin, skin lesion develops expansion gradually, the complete depigmentation of melanin, demarcate clear with normal skin, be creamy white or porcelain white, differ in size, shape is indefinite, can be circle, oval, ground figure etc.Number not etc., from single skin lesion to multiple white macula, all can not fall ill by any position of whole body.
Publication No. CN 103845545 A(application number 201210512202.5) Chinese patent literature disclose one and treat leukodermic Washout traditional Chinese medicine, described formula forms by following weight: Herba Schizonepetae 10-14 gram, Radix Saposhnikoviae 13-17 gram, Fructus Tribuli 18-22 gram, Fructus Xanthii 13-17 gram, Radix Astragali 18-22 gram, Radix Salviae Miltiorrhizae 18-22 gram, Radix Angelicae Dahuricae 13-17 gram, Radix Angelicae Sinensis 13-17 gram, Rhizoma Chuanxiong 13-17 gram, Radix Sophorae Flavescentis 13-17 gram, Radix Clematidis 10-14 gram, Rhizoma Acori Graminei 13-17 gram, Rhizoma Atractylodis 13-17 gram.Publication No. CN 103893705 A(application number 201410157535.X) Chinese patent literature disclose a kind of by taking orally, washout treats leukodermic Chinese medicine, belong to technical field of Chinese medicines, endo-medicine is made up of following raw material medicaments: the Radix Rehmanniae, the Radix Angelicae Dahuricae, Fructus Psoraleae, Rhizoma Curcumae Longae, Rhizoma Smilacis Glabrae, Radix Bupleuri, Rhizoma Atractylodis, Herba Schizonepetae, Fructus Ligustri Lucidi, Caulis Spatholobi, Radix Polygoni Multiflori Preparata, Cortex Moutan, Fructus Lycii, Radix Angelicae Sinensis, Herba Epimedii, Radix Salviae Miltiorrhizae, Ramulus Uncariae Cum Uncis, Cortex Phellodendri, Caulis Polygoni Multiflori, Semen Persicae, Flos Carthami, Radix Glycyrrhizae.Wash-out medicine is by Herba Schizonepetae, and Semen Armeniacae Amarum, Alumen, Herba Menthae, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Fructus Forsythiae, Rhizoma Smilacis Glabrae, Radix Polygoni Multiflori, Radix Paeoniae Rubra, Radix Sophorae Flavescentis, Borneolum Syntheticum is made.Publication No. CN 104721367 A(application number 201510096733.4) Chinese patent literature disclose one and be used for the treatment of leukodermic Chinese medicine, be prepared from by the crude drug of following weight: Fructus Psoraleae 10 parts, Radix Polygoni Multiflori Preparata 8 parts, 8 parts, the Radix Rehmanniae, Rhizoma Chuanxiong 6 parts.
Because leukodermic pathogenesis is not yet clear and definite, be used for the treatment of leukodermic medicine on the market, effect is very different, and some side effect is comparatively large, and then effect is not remarkable for some, therefore needs the Chinese medicine formula developing a kind of determined curative effect, safety has no side effect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide the wide leukodermic outer lotion for the treatment of of a kind of Be very effective, the use safety suitability and preparation method.
Technical scheme of the present invention is:
One treats leukodermic outer lotion, is prepared from, is mass parts primarily of following bulk drugs: Herba Artemisiae Anomalae 10-15; Radix seu Caulis fici Martinii grass 8-13; China fir tower 6-14; Radix Arnebiae (Radix Lithospermi) 9-13; Herba Moslae 7-12; Flos tribuli 10-14; Radix Maesae Japonicae 8-15; Fructus Ligustri Lucidi 11-16; Herba Siegesbeckiae 7-14; Radix Cynanchi Paniculati 10-17; Herba Adenostemmatis 8-14; Fructus Psoraleae 9-15; Gold line 7-13; Semen Nigellae 8-12.
Preferred version is, Herba Artemisiae Anomalae 11-14; Radix seu Caulis fici Martinii grass 9-12; China fir tower 8-12; Radix Arnebiae (Radix Lithospermi) 10-12; Herba Moslae 9-10; Flos tribuli 11-13; Radix Maesae Japonicae 10-13; Fructus Ligustri Lucidi 12-15; Herba Siegesbeckiae 9-12; Radix Cynanchi Paniculati 12-15; Herba Adenostemmatis 10-12; Fructus Psoraleae 11-13; Gold line 9-11; Semen Nigellae 9-11.
More preferably, Herba Artemisiae Anomalae 12.5; Radix seu Caulis fici Martinii grass 10.5; China fir tower 10; Radix Arnebiae (Radix Lithospermi) 11; Herba Moslae 9.5; Flos tribuli 12; Radix Maesae Japonicae 11.5; Fructus Ligustri Lucidi 13.5; Herba Siegesbeckiae 10.5; Radix Cynanchi Paniculati 13.5; Herba Adenostemmatis 11; Fructus Psoraleae 12; Gold line 10; Semen Nigellae 10.
Described a kind of preparation method for the treatment of leukodermic outer lotion, step is as follows:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, it is (preferred: to add decocting in water 22-28 minute to add decocting in water 20-30 minute; Be more preferably: add decocting in water 25 minutes), take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and soaks 25-35 minute (preferably: soak 28-32 minute; Be more preferably: soak 30 minutes), be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverize and sieve together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, each decocting time is 16-26 minute, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
Described a kind of preparation method for the treatment of leukodermic outer lotion, it is that the 0.8-1.6 of crude drug quality is doubly (preferred: to add 1.0-1.4 times that Semen sojae atricolor amount is crude drug quality that step (1) adds Semen sojae atricolor amount; Be more preferably: add 1.2 times that Semen sojae atricolor amount is crude drug quality).
Described a kind of preparation method for the treatment of leukodermic outer lotion, step (2) adds liquorice beverage and was as the criterion there not to be crude drug 1cm.
Described a kind of preparation method for the treatment of leukodermic outer lotion, it is (preferred: to pulverize 90-120 mesh sieve that step (3) pulverized 70-140 mesh sieve; Be more preferably: pulverized 105 mesh sieves).
Described a kind of preparation method for the treatment of leukodermic outer lotion, step (4) twice amount of water is the 6-8 of boiled crude drug quality doubly (preferred: twice amount of water is 7 times of boiled crude drug quality).
Described a kind of preparation method for the treatment of leukodermic outer lotion, each decocting time of step (4) is 19-23 minute (preferred: decocting time is 21 minutes).
Present invention also offers and described a kind ofly treat the application of leukodermic outer lotion when preparing treatment leucoderma medicament.
One provided by the invention treats leukodermic outer lotion formulation science, and preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, and safety has no side effect;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of pathogenic wind expelling speckle dispelling, the liver and the kidney tonifying;
3, Chinese crude drug selected by the present invention, collocation rationally, both can be dispelled vitiligo, can also strengthen body immunity.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Artemisiae Anomalae: have another name called Herba Artemisiae Anomalae grass, Herba Senecionis Scandentis is the wounded in the battle herb of Compositae sagebruss artemisia anomalas.The property of medicine: stem is cylindrical, surperficial brown color or brown-green, matter is hard and crisp, frangibility, the integrated spike panicle of head inflorescence, withered yellow, gas fragrance, bitter in the mouth, pungent, warm in nature.Composition: mainly containing arteanoflavone, tricin, apigenin, Palmic acid etc.Find according to modern pharmacological research, this medical instrument has effect of anti-hypoxia, blood circulation promoting and blood stasis dispelling, removing food stagnancy, hemostasia and detumescence, for amenorrhea due to stagnation of blood, and abdominal pain due to retention of food, hematuria, the diseases such as scald.
Radix seu Caulis fici Martinii grass: base is former: be rattan and the leaf of the blunt calyx Radix clematidis floridae of ranunculaceae plant.Nature and flavor: bitter in the mouth; Bitter; Cool in nature.Gui Jing: lung, spleen channel.Function cures mainly: expelling wind and clearing away heat; With network pain relieving.Main rheumatic arthritis; Rubella pruritus; Skin ulcer scabies; Toxic swelling; Acute catarrhal conjunctivitis pain; And dysuria.
Shan Ta: base is former: be the cone of Taxodiaceae Cunninghamia plant Lignum seu Ramulus Cunninghamiae Lanceolatae.The property of medicine: pungent, tepor.Function cures mainly: warming the kidney to invigorate YANG, and parasite killing detoxifies, mind calming, cough-relieving.Cure mainly seminal emission, sexual impotence, vitiligo, acute mastitis, cardiopalmus, cough.
Radix Arnebiae (Radix Lithospermi): base is former: be the root of comfrey Radix Arnebiae (Radix Lithospermi), the false Radix Arnebiae (Radix Lithospermi) in Xinjiang-Tibet or Onosma paniculatum.Chemical analysis: Radix Arnebiae (Radix Lithospermi) contains Acetyl-shikonin Acetylshikonin, isobutyryl shikonin, β, beta-dimethyl-propylene shikonin, β-Hydroxyisovalerylshikonin, 3,4-dimethyl pentene-3-acyl group shikonins.Nature and flavor: bitter, cold.Gui Jing: enter percardium, Liver Channel.Function cures mainly: removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.
Herba Moslae: base is former: be whole herb with root or the aerial parts of labiate Mosla chinensis Maxim.cv.Jiangxiangru or Mosla chinensis.Nature and flavor: acrid in the mouth; Slightly warm in nature.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: diaphoresis expelling summer-heat, and middle knot wets, line water detumescence.The main moon in summer affection of exogenous wind-cold; Internal injury is in wet; Fever with aversion to cold; Have a headache lossless; Epigastric pain; Vomiting and diarrhoea; Dysuria; Edema.
Flos tribuli: base is former: be the flower of zygophyllaceae plant Fructus Tribuli.Nature and flavor: pungent; Temperature.Gui Jing: Liver Channel.Function cures mainly: dispel the wind and blood.Main vitiligo.
Radix Maesae Japonicae: base is former: be root or the stem and leaf of Myrsinacea plant Radix Maesae Japonicae.Nature and flavor: bitter; Cold in nature.Function cures mainly: dispelling wind evil; Solution epidemic disease poison; Subside a swelling swollen.Main hot infectious disease; Cold and heat send out have a rest indefinite; Body aches; Irritated; Thirsty; Edema; Treating swelling and pain by traumatic injury; Traumatic hemorrhage.
Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, clear empty improving eyesight.Cure mainly Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.Compatibility and incompatibility of drugs: Deficiency and coldness of spleen and stomach is had loose bowels and the careful clothes of yang deficiency person.
Herba Siegesbeckiae: base is former: be the aerial parts of feverfew Herba Siegesbeckiae.Chemical analysis: Han Herba Siegesbeckiae tetrol, still containing alkaloid, amaroid.Nature and flavor: cold in nature, acrid in the mouth, hardship.Function cures mainly: wind-damp dispelling, sharp joint, removing toxic substances., soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema unable for rheumatic arthralgia, muscles and bones.
Radix Cynanchi Paniculati: base is former: be the dry root welding technology of Luo Mo section plant Radix Cynanchi Paniculati.Nature and flavor with return through: pungent, temperature.Return liver, stomach warp.Function with cure mainly: dispel the wind, removing dampness, pain relieving, antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, falls and flutters the pain of injury, rubella, eczema.
Herba Adenostemmatis: base is former: be the herb of feverfew adenostemma laveniaKuntze.Nature and flavor: acrid in the mouth; Micro-hardship; Property is shied.Function cures mainly: heat-clearing and toxic substances removing; Expelling wind and removing dampness.Main cold, fever; Icterohepatitis; Cough due to lung-heat; Laryngopharynx swelling and pain; Beriberoid pyretic arthralgia; Acute mastitis; Carbuncle furuncle; Venom.
Fructus Psoraleae: base is former: be the dry mature fruit of legumes psoraleae.To gather during fruit maturation in autumn infructescence.Dry, rub fruit, removing impurity.Nature and flavor with return through: pungent, bitter, temperature.Return kidney, spleen channel.Function with cure mainly: warming the kidney to activate YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha; External pathogenic wind expelling speckle dispelling.For insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily. Diarrhoea; External curing vitiligo, alopecia areata.
Gold line: base is former: be the herb of gentianaceae plant Hong Kong Tripterospermum affine.Nature and flavor: sweet; Pungent; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.Main cough due to lung-heat; Spitting of blood; Lung abscess; Urine leaching is puckery; Acute mastitis; Furuncle furuncle and phyma; Traumatic hemorrhage.
Semen Nigellae: base is former: be the seed of ranunculaceae plant Semen Nigellae.Nature and flavor: acrid in the mouth; Warm in nature.Gui Jing: return liver; Kidney channel.Function cures mainly: promoting blood circulation to restore menstrual flow; Diuresis and expelling stone; Kidney-tonifying and brain tonic.Cure mainly menoxenia; Amenorrhea; Breast is few; Edema; Lithangiuria; Dizziness and tinnitus; Early whitening of beard and hair; Cough with asthma; Scabies; Vitiligo.
embodiment 1one treats leukodermic outer lotion, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Artemisiae Anomalae 10 parts, Radix seu Caulis fici Martinii grass 8 parts, 6 parts, China fir tower, Radix Arnebiae (Radix Lithospermi) 9 parts, Herba Moslae 7 parts, Flos tribuli 10 parts, Radix Maesae Japonicae 8 parts, Fructus Ligustri Lucidi 11 parts of Herba Siegesbeckiaes 7 parts, Radix Cynanchi Paniculati 10 parts, Herba Adenostemmatis 8 parts, Fructus Psoraleae 9 parts, gold line 7 parts, Semen Nigellae 8 parts.Above-mentioned a kind of preparation method for the treatment of leukodermic outer lotion is:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with the Semen sojae atricolor of crude drug quality 0.8 times, be placed in container, add decocting in water 20 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and there be not crude drug 1cm to soak 25 minutes, be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverized 70 mesh sieves together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, twice amount of water is 6 times of boiled crude drug quality, each decocting time is 16 minutes, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
embodiment 2one treats leukodermic outer lotion, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Artemisiae Anomalae 15 parts, Radix seu Caulis fici Martinii grass 13 parts, 14 parts, China fir tower, Radix Arnebiae (Radix Lithospermi) 13 parts, Herba Moslae 12 parts, Flos tribuli 14 parts, Radix Maesae Japonicae 15 parts, Fructus Ligustri Lucidi 16 parts of Herba Siegesbeckiaes 14 parts, Radix Cynanchi Paniculati 17 parts, Herba Adenostemmatis 14 parts, Fructus Psoraleae 15 parts, gold line 13 parts, Semen Nigellae 12 parts.Above-mentioned a kind of preparation method for the treatment of leukodermic outer lotion is:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with the Semen sojae atricolor of crude drug quality 1.6 times, be placed in container, add decocting in water 30 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and there be not crude drug 1cm to soak 35 minutes, be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverized 140 mesh sieves together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, twice amount of water is 8 times of boiled crude drug quality, each decocting time is 26 minutes, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
Model case: xxx, women, 12 years old.Main suit: the white macula of unknown cause appears in face and cervical region.Medical history: found before patient half a year that depigmentation macule appears in skin of face, in pale, after increase gradually, demarcate clear with normal skin, be ellipse substantially, number progressively increases, after spread to cervical region, through examination in hospital, be diagnosed as vitiligo.
Use the outer lotion of this example gained, one day twice, fumigation and wash method affected part 10-20 minute 30 days was a course for the treatment of, after patient uses a course for the treatment of, white macula obviously disappears, and adheres to three courses for the treatment of of use, patient skin is gain color gradually, and the regeneration of check melanin, white macula thoroughly disappears.
embodiment 3one treats leukodermic outer lotion, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Artemisiae Anomalae 11 parts, Radix seu Caulis fici Martinii grass 9 parts, 8 parts, China fir tower, Radix Arnebiae (Radix Lithospermi) 10 parts, Herba Moslae 9 parts, Flos tribuli 11 parts, Radix Maesae Japonicae 10 parts, Fructus Ligustri Lucidi 12 parts of Herba Siegesbeckiaes 9 parts, Radix Cynanchi Paniculati 12 parts, Herba Adenostemmatis 10 parts, Fructus Psoraleae 11 parts, gold line 9 parts, Semen Nigellae 9 parts.Above-mentioned a kind of preparation method for the treatment of leukodermic outer lotion is:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with the Semen sojae atricolor of crude drug quality 1.0 times, be placed in container, add decocting in water 22 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and there be not crude drug 1cm to soak 28 minutes, be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverized 90 mesh sieves together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, twice amount of water is 6 times of boiled crude drug quality, each decocting time is 19 minutes, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
Model case: xxx, male, 28 years old.Medical history: patient must have vitiligo 3 years, the large-area circular white macula of whole body dispersibility distribution, clear border, in speckle, hair bleaches, and have a strong impact on work and the life of patient, once took many medicines, symptom does not all take a turn for the better.
Use the outer lotion of this example gained upon somebody's introduction, one day twice, fumigation and wash method affected part 10-20 minute 30 days was a course for the treatment of, after patient uses two courses for the treatment of, white macula disappears over half, and the colour of skin is obviously recovered, and adheres to three courses for the treatment of of use, the white macula of patient all disappears, and follows up a case by regular visits to, do not recur after 1 year.
embodiment 4one treats leukodermic outer lotion, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Artemisiae Anomalae 14 parts, Radix seu Caulis fici Martinii grass 12 parts, 12 parts, China fir tower, Radix Arnebiae (Radix Lithospermi) 12 parts, Herba Moslae 10 parts, Flos tribuli 13 parts, Radix Maesae Japonicae 13 parts, Fructus Ligustri Lucidi 15 parts of Herba Siegesbeckiaes 12 parts, Radix Cynanchi Paniculati 15 parts, Herba Adenostemmatis 12 parts, Fructus Psoraleae 13 parts, gold line 11 parts, Semen Nigellae 11 parts.Above-mentioned a kind of preparation method for the treatment of leukodermic outer lotion is:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with the Semen sojae atricolor of crude drug quality 1.4 times, be placed in container, add decocting in water 28 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and there be not crude drug 1cm to soak 32 minutes, be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverized 120 mesh sieves together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, twice amount of water is 8 times of boiled crude drug quality, each decocting time is 23 minutes, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
embodiment 5one treats leukodermic outer lotion, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Artemisiae Anomalae 12.5 parts, Radix seu Caulis fici Martinii grass 10.5 parts, 10 parts, China fir tower, Radix Arnebiae (Radix Lithospermi) 11 parts, Herba Moslae 9.5 parts, Flos tribuli 12 parts, Radix Maesae Japonicae 11.5 parts, Fructus Ligustri Lucidi 13.5 parts of Herba Siegesbeckiaes 10.5 parts, Radix Cynanchi Paniculati 13.5 parts, Herba Adenostemmatis 11 parts, Fructus Psoraleae 12 parts, gold line 10 parts, Semen Nigellae 10 parts.Above-mentioned a kind of preparation method for the treatment of leukodermic outer lotion is:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with the Semen sojae atricolor of crude drug quality 1.2 times, be placed in container, add decocting in water 25 minutes, take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and there be not crude drug 1cm to soak 30 minutes, be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverized 105 mesh sieves together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, twice amount of water is 7 times of boiled crude drug quality, each decocting time is 21 minutes, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
test example 1gained one of the present invention treats the clinical practice of leukodermic outer lotion (embodiment 5):
Choose crowd: in March ,-2015 in April, 2014, according to medical case history, have patient 266 example meeting vitiligo diagnostic criteria in hospital's screening, age 10-62 year, 31.7 ± 2.6 years old mean age, the course of disease 2 months-16 years, wherein male patient 138 example, female patient 128 example.Diagnostic criteria: the depigmentation speckle 1. occurred the day after tomorrow or depigmentation macule.2. skin lesion boundary clear and form is irregular.3. skin lesion edge pigment is deepened.4. polychroism around the variable white or visible follicular orifice of hair in skin lesion.5. under Wood lamp, white macula is porcelain white.If 3 establishments can be diagnosed as vitiligo in above-mentioned 5.
Before test, patient is divided into two groups at random, experimental group 162 example and matched group 104 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention, one day twice, fumigation and wash method affected part 10-20 minute, within 30 days, is a course for the treatment of; Matched group uses other conventional medicines (compound recipe Radix Angelicae Dahuricae tincture, psoralea tincture, Tacrolimus paste etc.).During medication, Continuous Observation is carried out to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) fully recovers: white macula all disappears, and recovers normal skin tone.(2) effective: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion Mian Ji≤50%.(3) take a turn for the better: white macula partial remission or reduce.(4) invalid: the regeneration of white macula non-pigment or expanded range.
Clinical effectiveness: after the treatment of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
As shown in Table 1, the total effective rate of experimental group is 98.1%, and the total effective rate 82.7% of matched group, be starkly lower than the therapeutic effect of experimental group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.Treatments period, all there is not untoward reaction in two groups of patients, illustrates that products obtained therefrom of the present invention has no side effect safely.
The Chinese medicine used in the present invention, Herba Artemisiae Anomalae can blood circulation promoting and blood stasis dispelling, Radix seu Caulis fici Martinii grass expelling wind and clearing away heat, Shan Ta can warming the kidney to invigorate YANG, and Radix Arnebiae (Radix Lithospermi), Herba Adenostemmatis, gold line can heat-clearing and toxic substances removing, and Herba Moslae can wet with middle knot, Flos tribuli can dispel the wind and blood, and Radix Maesae Japonicae can dispelling wind evil, Fructus Ligustri Lucidi can liver and kidney tonifying Herba Siegesbeckiae can expelling wind and removing dampness, Radix Cynanchi Paniculati can antalgesic-antipruritic, and Fructus Psoraleae can pathogenic wind expelling speckle dispelling, and Semen Nigellae can promoting blood circulation to restore menstrual flow, multiple medical material synergism, effectively can give play to effect of pathogenic wind expelling speckle dispelling, the liver and the kidney tonifying.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat a leukodermic outer lotion, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Herba Artemisiae Anomalae 10-15; Radix seu Caulis fici Martinii grass 8-13; China fir tower 6-14; Radix Arnebiae (Radix Lithospermi) 9-13; Herba Moslae 7-12; Flos tribuli 10-14; Radix Maesae Japonicae 8-15; Fructus Ligustri Lucidi 11-16; Herba Siegesbeckiae 7-14; Radix Cynanchi Paniculati 10-17; Herba Adenostemmatis 8-14; Fructus Psoraleae 9-15; Gold line 7-13; Semen Nigellae 8-12.
2. one as claimed in claim 1 treats leukodermic outer lotion, it is characterized in that, Herba Artemisiae Anomalae 11-14; Radix seu Caulis fici Martinii grass 9-12; China fir tower 8-12; Radix Arnebiae (Radix Lithospermi) 10-12; Herba Moslae 9-10; Flos tribuli 11-13; Radix Maesae Japonicae 10-13; Fructus Ligustri Lucidi 12-15; Herba Siegesbeckiae 9-12; Radix Cynanchi Paniculati 12-15; Herba Adenostemmatis 10-12; Fructus Psoraleae 11-13; Gold line 9-11; Semen Nigellae 9-11.
3. one as claimed in claim 1 treats leukodermic outer lotion, it is characterized in that, Herba Artemisiae Anomalae 12.5; Radix seu Caulis fici Martinii grass 10.5; China fir tower 10; Radix Arnebiae (Radix Lithospermi) 11; Herba Moslae 9.5; Flos tribuli 12; Radix Maesae Japonicae 11.5; Fructus Ligustri Lucidi 13.5; Herba Siegesbeckiae 10.5; Radix Cynanchi Paniculati 13.5; Herba Adenostemmatis 11; Fructus Psoraleae 12; Gold line 10; Semen Nigellae 10.
4. a kind of preparation method for the treatment of leukodermic outer lotion as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Shan Ta, Fructus Ligustri Lucidi, Fructus Psoraleae and Semen Nigellae and eliminate impurity, with Chinese liquor rinse three times, mix thoroughly with Semen sojae atricolor, be placed in container, it is (preferred: to add decocting in water 22-28 minute to add decocting in water 20-30 minute; Be more preferably: add decocting in water 25 minutes), take out, removing Semen sojae atricolor, dry;
(2) get Flos tribuli wash quickly clean, chopping, is placed in container, adds liquorice beverage and soaks 25-35 minute (preferably: soak 28-32 minute; Be more preferably: soak 30 minutes), be placed in by container in baking box, heating, drying, until surface is in burned black shape, taking-up is pulverized;
(3) get Radix Arnebiae (Radix Lithospermi), Herba Moslae and Radix Cynanchi Paniculati and clean remove impurity, be cut into lamellar, be placed in frying pan, drench into rice wine, stir-fry micro-Jiao to surface, takes out, pulverize and sieve together with step (1) made crude drug;
(4) Herba Artemisiae Anomalae, Radix seu Caulis fici Martinii grass, Radix Maesae Japonicae, Herba Siegesbeckiae, Herba Adenostemmatis and gold line are cleaned, removing impurity, be placed in non iron container, decoct with water twice, each decocting time is 16-26 minute, collecting by filtration filtrate, merges twice gained filtrate;
(5) mixed with filtrate by step (2) (3) (4) made crude drug, heating is concentrated into 1/3 of original volume, filters and leaves standstill, obtaining outer lotion.
5. a kind of preparation method for the treatment of leukodermic outer lotion as claimed in claim 4, is characterized in that, step (1) add Semen sojae atricolor amount be the 0.8-1.6 of crude drug quality doubly (preferred: add Semen sojae atricolor amount be the 1.0-1.4 of crude drug quality doubly; Be more preferably: add 1.2 times that Semen sojae atricolor amount is crude drug quality).
6. a kind of preparation method for the treatment of leukodermic outer lotion as claimed in claim 4, it is characterized in that, step (2) adds liquorice beverage and was as the criterion there not to be crude drug 1cm.
7. a kind of preparation method for the treatment of leukodermic outer lotion as claimed in claim 4, is characterized in that, it is (preferred: to pulverize 90-120 mesh sieve that step (3) pulverized 70-140 mesh sieve; Be more preferably: pulverized 105 mesh sieves).
8. a kind of preparation method for the treatment of leukodermic outer lotion as claimed in claim 4, is characterized in that, step (4) twice amount of water is the 6-8 of boiled crude drug quality doubly (preferred: twice amount of water is 7 times of boiled crude drug quality).
9. a kind of preparation method for the treatment of leukodermic outer lotion as claimed in claim 4, is characterized in that, each decocting time of step (4) is 19-23 minute (preferred: decocting time is 21 minutes).
10. a kind of as described in as arbitrary in claim 1-3 treats the application of leukodermic outer lotion when preparing treatment leucoderma medicament.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244221A (en) * | 2007-02-13 | 2008-08-20 | 汪建国 | Composition for external application and preparation method |
| CN104147496A (en) * | 2014-08-08 | 2014-11-19 | 徐辉 | Drug for treating leucoderma and preparation method thereof |
| CN104740222A (en) * | 2013-12-27 | 2015-07-01 | 孔祥军 | Traditional Chinese medicine for treating leucoderma |
-
2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244221A (en) * | 2007-02-13 | 2008-08-20 | 汪建国 | Composition for external application and preparation method |
| CN104740222A (en) * | 2013-12-27 | 2015-07-01 | 孔祥军 | Traditional Chinese medicine for treating leucoderma |
| CN104147496A (en) * | 2014-08-08 | 2014-11-19 | 徐辉 | Drug for treating leucoderma and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 胡献国，李春日主编: "《中国膏药配方配制全书》", 30 April 2014, 辽宁科学技术出版社 * |
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Application publication date: 20151104 |