CN101244221A - Composition for external application and preparation method - Google Patents
Composition for external application and preparation method Download PDFInfo
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- CN101244221A CN101244221A CNA2007100374601A CN200710037460A CN101244221A CN 101244221 A CN101244221 A CN 101244221A CN A2007100374601 A CNA2007100374601 A CN A2007100374601A CN 200710037460 A CN200710037460 A CN 200710037460A CN 101244221 A CN101244221 A CN 101244221A
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Abstract
The invention discloses a topical skin composition, the preparation method and application in the treatment of psoriasis, herpes zoster and neuro dermatitis, which comprises (a) an acceptable carrier in pharmacy, and (b) effective dose of water extract of raw herbal materials or extract of waterborne organic solution; wherein, the raw herbal materials comprises goldenrod, clove, radixstemonae, seed of cowherb, pseudolari cortex, pubescent holly, glycyrrhiza, dictamnus dasycarpus, angelica sinensis, safflower, gleditsia sinensis lam, uncaria, cynachum paniculatum and Chinese yam.
Description
Technical field
The present invention relates to the plant extract field.Relate more specifically to the composition for external application and method for making and the purposes that contain the Chinese crude drug extract from a kind of.
Background technology
Skin is the organ of body maximum, is between body and the external environment.It is the first line of defence that the protection human body is avoided extraneous machinery, chemistry, physical attack, and is complete and advantages of good skin can reduce the influence of outer bound pair body, keeps the normal activities of body.The gross area of adult skin is about 1.5-2 square metre, accounts for 16% of body wt, and neonate is about 0.2-1 square metre.Human body skin thickness is 0.5-4 millimeter (not comprising fat), can be because of the different difference to some extent at age, sex and position, and thinner than adult skin as child, old people's skin, female skin is thinner than male skin; The skin that extremity are bent side, eyelid, breast, pudendum is thinner, and the skin behind buttocks, palm, vola and the pillow is thicker.
Dermatosis is clinical common disease.For various reasons, various pathological changes can take place in skin, and 100 kinds of fixed dermatosiss are multiple, for example eczema, psoriasis, herpes zoster, neurodermatitis etc., and the harm that is caused can not look down upon.
Though the treatment dermatosis has multiple therapeutic agent, yet numerous therapeutic agent is only applicable to a kind of or a few dermatosis.Especially for dermatosiss such as psoriasis, herpes zoster, neurodermatitiss, also lack effective treatment means at present.
In sum, still lack the external used medicine for the treatment of various skin diseases such as psoriasis, herpes zoster, neurodermatitis effectively at present.Therefore, this area presses for provides a kind of compositions with above-mentioned effect.
Summary of the invention
The present invention aims to provide a kind of effectively composition for external application and preparation method thereof.
In a first aspect of the present invention, a kind of compositions is provided, it contains (a) pharmaceutically acceptable carrier and (b) water extract of the raw medicinal material of effective dose or the extract of aqueous organic solvent, and described raw medicinal material comprises Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae;
And the extract of described medical material accounts for the 0.02-99% of composition total weight, preferably 0.1-90%, more preferably 0.2-50%.
In another preference, described raw medicinal material also comprises one or more complementary raw medicinal materials that are selected from down group: Fructus Anisi Stellati, Herba Chenopodii, Folium eucalypti globueli (Eucalyptus globulus Labill.), the Folium Ligustri Lucidi, Folium Hibisci Mutabilis, Herba Moslae Chinensis, Fructus Liquidambaris, Herba Caryopteridis Incanae, Radix Salviae Miltiorrhizae, Herba Lobeliae Chinensis, Radix Polygoni Multiflori, Radix Sanguisorbae, Herba Polygoni Perfoliati, Herba Tropaeoli, Fructus Forsythiae, Herba Lycopodii, Herba Andrographis, Cortex Betulae Luminiferae, Herba Centellae, Herba Spirodelae, Radix Scutellariae, Folium pterocaryae stenopterae, Rhizoma Smilacis Chinensis, Radix Arnebiae (Radix Lithospermi) and Flos Hibisci Mutabilis.
In another preference, described medical material comprises:
0.5-8 weight portion Herba Solidaginis;
0.5-8 weight portion Flos Caryophylli;
0.5-8 the weight portion Radix Stemonae;
0.5-8 weight portion Semen Vaccariae;
0.5-8 weight portion Cortex Hibisci;
0.3-6 weight portion Radix Ilicis Pubescentis;
0.2-4 weight portion Radix Glycyrrhizae;
0.2-4 weight portion Cortex Dictamni;
0.5-8 weight portion Radix Angelicae Sinensis;
0.2-4 weight portion Flos Carthami;
0.2-4 weight portion Spina Gleditsiae;
0.1-2 weight portion Ramulus Uncariae Cum Uncis;
0.5-8 weight portion Radix Cynanchi Paniculati; With
0.5-8 weight portion Rhizoma Dioscoreae
In another preference, described compositions also comprises one or more medical materials that are selected from down group:
0.2-4 weight portion Fructus Anisi Stellati;
0.3-6 weight portion Herba Chenopodii;
0.3-6 weight portion Folium eucalypti globueli (Eucalyptus globulus Labill.);
0.5-8 the weight portion Folium Ligustri Lucidi;
0.5-8 weight portion Folium Hibisci Mutabilis;
0.5-8 weight portion Herba Moslae Chinensis;
0.1-2 weight portion Fructus Liquidambaris;
0.2-4 weight portion Herba Caryopteridis Incanae;
0.2-4 weight portion Radix Salviae Miltiorrhizae;
0.3-6 weight portion Herba Lobeliae Chinensis;
0.2-4 weight portion Radix Polygoni Multiflori;
0.3-6 weight portion Radix Sanguisorbae;
0.3-6 weight portion Herba Polygoni Perfoliati;
0.1-2 weight portion Herba Tropaeoli;
0.1-2 weight portion Fructus Forsythiae;
0.3-6 weight portion Herba Lycopodii;
0.3-6 weight portion Herba Andrographis;
0.3-6 weight portion Cortex Betulae Luminiferae;
0.2-4 weight portion Herba Centellae;
0.2-4 weight portion Herba Spirodelae;
0.2-4 weight portion Radix Scutellariae;
0.3-6 weight portion Folium pterocaryae stenopterae;
0.5-8 weight portion Rhizoma Smilacis Chinensis;
0.2-4 weight portion Radix Arnebiae (Radix Lithospermi);
0.1-2 weight portion Flos Hibisci Mutabilis.
In another preference, described crude drug contains:
1-6 weight portion Herba Solidaginis;
1-6 weight portion Flos Caryophylli;
The 1-6 weight portion Radix Stemonae;
1-6 weight portion Semen Vaccariae;
1-6 weight portion Cortex Hibisci;
0.5-5 weight portion Radix Ilicis Pubescentis;
0.5-3 weight portion Radix Glycyrrhizae;
0.5-3 weight portion Cortex Dictamni;
1-6 weight portion Radix Angelicae Sinensis;
0.5-3 weight portion Flos Carthami;
0.5-3 weight portion Spina Gleditsiae;
0.2-1.8 weight portion Ramulus Uncariae Cum Uncis;
1-6 weight portion Radix Cynanchi Paniculati;
1-6 weight portion Rhizoma Dioscoreae;
In another preference, described crude drug contains:
2-5 weight portion Herba Solidaginis;
2-5 weight portion Flos Caryophylli;
The 2-5 weight portion Radix Stemonae;
2-5 weight portion Semen Vaccariae;
2-5 weight portion Cortex Hibisci;
1-4.5 weight portion Radix Ilicis Pubescentis;
1-3 weight portion Radix Glycyrrhizae;
1-3 weight portion Cortex Dictamni;
2-5 weight portion Radix Angelicae Sinensis;
1-3 weight portion Flos Carthami;
1-3 weight portion Spina Gleditsiae;
0.5-1.5 weight portion Ramulus Uncariae Cum Uncis;
2-5 weight portion Radix Cynanchi Paniculati; With
2-5 weight portion Rhizoma Dioscoreae.
In another preference, the content of complementary raw medicinal material is as follows:
0.5-3 weight portion Fructus Anisi Stellati;
0.5-5 weight portion Herba Chenopodii;
0.5-5 weight portion Folium eucalypti globueli (Eucalyptus globulus Labill.);
The 1-6 weight portion Folium Ligustri Lucidi;
1-6 weight portion Folium Hibisci Mutabilis;
1-6 weight portion Herba Moslae Chinensis;
0.2-1.8 weight portion Fructus Liquidambaris;
0.5-3 weight portion Herba Caryopteridis Incanae;
0.5-3 weight portion Radix Salviae Miltiorrhizae;
0.5-5 weight portion Herba Lobeliae Chinensis;
0.5-3 weight portion Radix Polygoni Multiflori;
0.5-5 weight portion Radix Sanguisorbae;
0.5-5 weight portion Herba Polygoni Perfoliati;
0.2-1.8 weight portion Herba Tropaeoli;
0.2-1.8 weight portion Fructus Forsythiae;
0.5-5 weight portion Herba Lycopodii;
0.5-5 weight portion Herba Andrographis;
0.5-5 weight portion Cortex Betulae Luminiferae;
0.5-3 weight portion Herba Centellae;
0.5-3 weight portion Herba Spirodelae;
0.5-3 weight portion Radix Scutellariae;
0.5-5 weight portion Folium pterocaryae stenopterae;
1-6 weight portion Rhizoma Smilacis Chinensis;
0.5-3 weight portion Radix Arnebiae (Radix Lithospermi); With
0.2-1.8 weight portion Flos Hibisci Mutabilis.
In another preference, described compositions is spray, ointment, ointment, liniment, lotion or gel.
In another preference, by the gross dry weight amount of described medical material, every gram or every milliliter of described compositions contain corresponding to 0.01-10 and restrain dried medical material, more preferably restrain dried medical material corresponding to 0.05-2.
In a second aspect of the present invention, a kind of above-mentioned method for compositions for preparing is provided, it comprises step:
(i) described medical material was mixed 0.5-50 days with water or aqueous organic solvent, form mixed liquor;
(ii) filter mixed liquor, obtain filtrate, thereby obtain extract;
(iii) extract is mixed with pharmaceutically acceptable carrier, form compositions;
Perhaps
Described method comprises that the aqueous extract with each medical material mixes, and forms and extracts mixture, will extract mixture again and mix with pharmaceutically acceptable carrier, forms compositions.
In another preference, described aqueous organic solvent is the mixed solution of water and alcohol (as ethanol), and wherein Chun percent by volume is 5-85% (v/v), more preferably is 10-50%.
In another preference, described alcohol comprises methanol, ethanol, propanol or its combination.
In another preference, comprise that also the extract to obtaining carries out drying in (ii) in step.
In another preference, described raw medicinal material also contains one or more complementary raw medicinal materials that are selected from down group: Fructus Anisi Stellati, Herba Chenopodii, Folium eucalypti globueli (Eucalyptus globulus Labill.), the Folium Ligustri Lucidi, Folium Hibisci Mutabilis, Herba Moslae Chinensis, Fructus Liquidambaris, Herba Caryopteridis Incanae, Radix Salviae Miltiorrhizae, Herba Lobeliae Chinensis, Radix Polygoni Multiflori, Radix Sanguisorbae, Herba Polygoni Perfoliati, Herba Tropaeoli, Fructus Forsythiae, Herba Lycopodii, Herba Andrographis, Cortex Betulae Luminiferae, Herba Centellae, Herba Spirodelae, Radix Scutellariae, Folium pterocaryae stenopterae, Rhizoma Smilacis Chinensis, Radix Arnebiae (Radix Lithospermi) and Flos Hibisci Mutabilis.
In a third aspect of the present invention, the purposes of a kind of Chinese medicine medicinal material composition or its aqueous extract is provided, wherein, described Chinese medicine medicinal material composition comprises: Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae, described Chinese medicine medicinal material composition or its aqueous extract are used to prepare composition for external application.
In another preference, described Chinese medicine composition can also contain one or more complementary raw medicinal materials that are selected from down group: Fructus Anisi Stellati, Herba Chenopodii, Folium eucalypti globueli (Eucalyptus globulus Labill.), the Folium Ligustri Lucidi, Folium Hibisci Mutabilis, Herba Moslae Chinensis, Fructus Liquidambaris, Herba Caryopteridis Incanae, Radix Salviae Miltiorrhizae, Herba Lobeliae Chinensis, Radix Polygoni Multiflori, Radix Sanguisorbae, Herba Polygoni Perfoliati, Herba Tropaeoli, Fructus Forsythiae, Herba Lycopodii, Herba Andrographis, Cortex Betulae Luminiferae, Herba Centellae, Herba Spirodelae, Radix Scutellariae, Folium pterocaryae stenopterae, Rhizoma Smilacis Chinensis, Radix Arnebiae (Radix Lithospermi) and Flos Hibisci Mutabilis.
In another preference, described composition for external application is used for the treatment of the disease that is selected from down group: eczema, tinea disease, neurodermatitis, herpes zoster, psoriasis, decubital ulcer, skin pruritus, carbuncle, tinea unguium, the vitiligo of dispelling, functions of removing chloasma.
In a fourth aspect of the present invention, a kind of aqueous extract or water extract of Chinese medicine medicinal material composition are provided, and described Chinese medicine medicinal material composition comprises following medical material: Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.
The present invention also provides described aqueous extract or the purposes of water extract aspect the medicine of preparation treatment dermatosis.
The specific embodiment
The inventor is through extensively and in depth research, according to the principle of Chinese medicine " monarch ", prepared first and contained Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.The medical material mixture.Test shows that the water extract of described medical material mixture or the extract of aqueous organic solvent have the effect of good skin external, and it can be used for the treatment of various skin diseases such as psoriasis, herpes zoster, neurodermatitis effectively.
As used in this description and claims, " raw medicinal material " of the present invention is defined as follows:
Herba Solidaginis (Herba seu Radix Solidaginis): the herb and the root of Compositae Herba Solidaginis platymiscium Herba Solidaginis.Has wind and heat dispersing, the effect of subduing swelling and detoxicating.The headache that can cure cold, laryngopharynx swelling and pain, fungal infection of hand and foot.
Flos Caryophylli (Flos Caryophylli): the alabastrum of Myrtaceae Eugenia plant of clove.Can control the tinea disease.
Fructus Anisi Stellati (Fructus Anisi Stellati): the fruit of Winteraceae Illicium plant Fructus Anisi Stellati.Can control dried, beriberi caused by pathogenic damp.
Herba Chenopodii (Herba Chenopodii Ambrosiodis): the band fruit ear herb of Chenopodiaceae Chenopodium plant Herba Chenopodii.Have and dispel the wind, parasite killing stimulates the menstrual flow, the analgesic effect.Can control the skin rheumatic arthralgia, skin eczema, snake bite and insect sting.
Rhizoma Dioscoreae (Rhizoma Dioscoreae Oppositae): the tuber of Dioscoreaceae yam Rhizoma Dioscoreae (Dioscoreaopposite Thunb.).Rhizoma Dioscoreae contains phytoprotein and 19 seed amino acids, and it has 6 kinds of essential amino acids, and higher tonic value is arranged.Also contain various trace elements, crucial meaning is arranged for defying age.Can moisten fur.
Folium eucalypti globueli (Eucalyptus globulus Labill.) (Folium Eucalypti Globuli): the adult leaf of Myrtaceae eucalyptus plant Eucalyptus globulus Labill.But training the mind is through dermatitis, eczema, carbuncle pyogenic infections from tumour or sore.
The Folium Ligustri Lucidi: the leaf of Oleaceae plant Ligustrum plant Fructus Ligustri Lucidi Ligustrum Lucidum Ait..Have and dispel the wind, detumescence, analgesic effect.Can control the skin ulcer turgescence canker, scald stomatitis.The effect that also has heat clearing away, antiinflammatory, pain relieving, granulation promoting.
The Radix Stemonae (Radix Stemonae): the root of Stemonaceae Stemona plant Radix Stemonae, Radix stemonae japonicae and radix stemonae tuberosae.Can control skin scabies, eczema.
Semen Vaccariae (Semen Vaccariae): the seed of Caryophyllaceae Semen Vaccariae platymiscium Vaccaria segetalis.Have promoting the circulation of blood and stimulate the menstrual flow, the effect of skin ulcer is held back in detumescence.
Cortex Hibisci (Cortex Hibisci): peel of stem or the root bark of Malvaceae Hibiscus plant Hibiscus syriacus L. (Hibiscus syriacus L.).Has heat clearing away, dampness removing, detoxifcation, itching relieving effect.Can control scabies.
Folium Hibisci Mutabilis (Folium Hibisci Mutabilis Folium Hibisci Mutabidis): the leaf of Malvaceae Hibisci Mutabilis platymiscium Hibisci Mutabilis Hibiscus mutabilis L..Has removing heat from blood, detoxifcation, detumescence, analgesic effect.It is glad swollen to control carbuncle, and the herpes zoster that is burdened with (herpes zoster) is scalded.
Flos Hibisci Mutabilis (Flos Hibisci Mutabilis Flos Hibisci Mutabilidis): the flower of Malvaceae Hibisci Mutabilis platymiscium Hibisci Mutabilis Hibiscus mutabilis L..Has heat clearing away, removing heat from blood, detumescence, antidotal effect.Can control carbuncle, furuncle is scalded.
Radix Ilicis Pubescentis (Radix Ilicis Pubescentis): be the root of Aquifoliaceae Holly Radix Ilicis Pubescentis (Ilexpubescens Hook.et Arn.).Has heat-clearing and toxic substances removing, the effect of blood circulation and channel invigorating.Can control the skin acute suppurative inflammation.
Radix Glycyrrhizae (Radix et Rhizoma Glycyrrhizae): the root and rhizome of pulse family glycyrrhiza genus Radix Glycyrrhizae, Glycyrrhiza glabra L., Glycyrrhiza inflata Bat..Can separate all poison of drug.
Herba Moslae Chinensis (Mosla chinensis Maxim., Herba Moslae Herba Moslae): the whole herb with root or the aerial parts of Labiatae Herba Moslae Scabrae platymiscium Mosla chinensis Maxim.cv.Jiangxiangru or ofMosla Chinensis Maxim.Have and drive away summer heat, invigorate blood circulation, regulate the flow of vital energy, the effect of removing dampness.Can control traumatic injury stasis of blood pain, eczema, furuncle and phyma.
Fructus Liquidambaris (Fructus Liquidambaris): the fruit of Hamamelidaceae Liquidambar plant Chinese sweet gum Liquidambarformosana Hance.Has dispelling wind and removing obstruction in the collateral, the effect of diuretic dehumidifying.Can control scabies, eczema.
Cortex Dictamni (Cortex Dictamni): the root bark of Rutaceae shaggy-fruited dittany platymiscium shaggy-fruited dittany.Have and dispel the wind, dampness, heat clearing away, antidotal effect.Can control the wind heat sore, scabies, itchy skin eruption.
Herba Caryopteridis Incanae (Herba Caryopteridis Incanae): the herb of Verenaceae Herba caryopteridis nepetaefoliae's platymiscium Herba Caryopteridis Incanae.Can control traumatic injury, skin pruritus, eczema, skin ulcer is swollen.
Radix Salviae Miltiorrhizae (Radix Salviae Miltiorrhizae): the root of Labiatae salvia Radix Salviae Miltiorrhizae.Has blood circulation promoting and blood stasis dispelling, evacuation of pus, analgesic effect.Can control and gather arthralgia.
Herba Lobeliae Chinensis (Herba Lobeliae Chinensis): the whole herb with root of campanulaceae lobelia plant Herba Lobeliae Chinensis.Has detumescence, the antidotal effect.Can control tympanites, snakebite, furuncle, toxic swelling, eczema, tinea disease.
Radix Polygoni Multiflori (Radix Polygoni Multiflori): be the tuber of Polygonaceae arsesmart Radix Polygoni Multiflori.Have and nourish blood, the effect of dispeling the wind can be treated furuncle and phyma.
Radix Sanguisorbae (Radix Sanguisorbae): the root of Rosaceae burnet plant Radix Sanguisorbae, the Radix Sanguisorbae that comes into leaves.Has cooling blood for hemostasis, the effect of heat-clearing and toxic substances removing.Can control carbuncle, eczema, incised wound, burn.
Herba Polygoni Perfoliati (Herba Polygoni Perfoliati): the herb of Polygonaceae arsesmart Herba Polygoni Perfoliati.Have inducing diuresis to remove edema, heat clearing away is invigorated blood circulation, the antidotal effect.Can control eczema; External can be controlled scabies.Change the pipe granulation promoting.
Radix Angelicae Sinensis (Radix Angelicae Sinensis): the root of Umbelliferae archangel Radix Angelicae Sinensis.Can control injury from falling down.
Flos Carthami (Flos Carthami): the flower of Compositae Flos Carthami platymiscium Flos Carthami.Can control carbuncle, injury from falling down.
Herba Tropaeoli: but the herb of nasturtium nasturtium nasturtium Tropaeolum majus L..Can control sore.Heat-clearing and toxic substances removing.
Fructus Forsythiae (Fructus Forsythiae): be the fruit of Oleaceae forsythia Fructus Forsythiae.Has heat clearing away, detoxifcation, eliminating stagnation, repercussive effect.Can control the carbuncle and ulcer toxic swelling.
Herba Lycopodii (Herba Lycopodii): the herb of Lycopodiaceae Lycopodium plant Lycopodium clavatum, Central China Lycopodium clavatum and Fructus Seu Herba Pubescentis platymiscium Fructus Seu Herba Pubescentis.Can control herpes zoster.
Spina Gleditsiae (Spina Gleditsiae): be the Spina jujubae of pulse family Gleditsia plant Fructus Gleditsia and mountain Fructus Gleditsia.Have the wind of searching, draw out pus by applying a plaster to the affected part, detumescence, the effect of evacuation of pus.Can control carbuncle, sore, leprosy, tinea skin ulcer.
Ramulus Uncariae Cum Uncis (Ramulus Uncariae Cum Uncis): be the stem and branch with belt hook of Rubiaceae wild gambier plant Ramulus Uncariae Cum Uncis, Uncaria sinensis (Oliv.) Havil., Ramulus Uncariae macrophyllae.Has heat clearing away, the effect that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.
Herba Andrographis (Herba Andrographis): the herb of Acanthaceae Herba Andrographis platymiscium Herba Andrographis.Has heat-clearing and toxic substances removing, the effect of removing heat from blood repercussive.Can control oropharynx and swell and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Cortex Betulae Luminiferae (Cortex betulae platyphyllae Cortex Betulae): the bark of Betulaceae Betula plant Betula platyphylla Suk..Has clearing away heat-damp and promoting diuresis, the effect of subduing swelling and detoxicating.Can control furuncle and phyma, prurigo is scalded.
Herba Centellae (Herba Centellae): the herb of Umbelliferae Centella plant Herba Centellae.Has clearing away heat-damp and promoting diuresis, the effect of subduing swelling and detoxicating.Can treat skin ulcer, as intractable wound, tuberculosis of skin, leprosy etc.
Radix Cynanchi Paniculati (Radix et Rhizoma Cynanchi Paniculati): the root and rhizome of asclepiadaceae Cynanchum plant Radix Cynanchi Paniculati, or whole herb with root.Has analgesia, cough-relieving, inducing diuresis to remove edema, the effect of promoting blood circulation and detoxication.Can control traumatic injury, eczema, urticaria, venom.
Herba Spirodelae (Herba Spirodelae): the herb of Lemnaceae duckweed platymiscium duckweed or Lemna plant Herba Spirodelae.Has heat clearing away, the antidotal effect.It is saturating to control macule, the wind heat urticaria, and skin pruritus, edema, the skin ulcer tinea is scalded.
Radix Scutellariae (Radix Scutellariae): the root of Labiatae Scutellaria plant Radix Scutellariae.Have the removing the relative excess fire, except that damp and hot, the hemostatic effect.Can control the carbuncle furuncle.
Folium pterocaryae stenopterae (Folium pterocaryae): the leaf of Juglandaceae Pterocarya Stenoptera platymiscium Pterocarya Stenoptera Pterocarya stenopteraC.DC..Can control skin ulcer cellulitis furuncle and phyma, the scabies pruritus due to wind pathogen, dermatitis and eczema is coated with mashed skin ulcer, burn.
Rhizoma Smilacis Chinensis (Rhizoma Smilacis Chinae): Liliaceae smilax plant Rhizoma Smilacis Chinensis rhizome.Has wind-damp dispelling, the effect of detumescence poison.Can treat psoriasis.
Radix Arnebiae (Radix Lithospermi) (Radix Arnebiae): the root of the false puccoon Radix Arnebiae of Boraginaceae, arnebia guttata Bunge and puccoon Radix Arnebiae (Radix Lithospermi).Has removing heat from blood and promoting blood circulation, heat clearing away, antidotal effect.Can control warm macule, purpura, burn, wet disease, erysipelas carbuncle and ulcer.
In above-mentioned medical material, Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.Be necessary medical material, all the other are complementary medical material.As used herein, " auxiliary medical material ", " complementary raw medicinal material " " extra medical material " or " optional medical material " are meant in the present composition and can add the medical material that also can not add.Usually, can make effect better after adding complementary medical material.
Compositions
The inventor provides a kind of extract according to the medication principle of Chinese medicine monarch, and it contains Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.The water extract or the aqueous organic solvent extract of the raw medicinal material (crude preparation) that constitutes.
Usually, the parts by weight of each raw medicinal material are as follows in the described mixture:
The content of the necessary medical material of table 1
| Medical material | Content | Preferred content | Optimum content |
| Herba Solidaginis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Flos Caryophylli | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| The Radix Stemonae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Semen Vaccariae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Cortex Hibisci | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Radix Ilicis Pubescentis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Radix Glycyrrhizae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Cortex Dictamni | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Angelicae Sinensis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Flos Carthami | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Spina Gleditsiae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Ramulus Uncariae Cum Uncis | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Radix Cynanchi Paniculati | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Rhizoma Dioscoreae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
In a preference, also can contain the water extract or the aqueous organic solvent extract of extra external preparation for skin medical material in the compositions of the present invention.Suitable skin external medical material example comprises, but is not limited to: Fructus Anisi Stellati, Herba Chenopodii, Folium eucalypti globueli (Eucalyptus globulus Labill.), the Folium Ligustri Lucidi, Folium Hibisci Mutabilis, Herba Moslae Chinensis, Fructus Liquidambaris, Herba Caryopteridis Incanae, Radix Salviae Miltiorrhizae, Herba Lobeliae Chinensis, Radix Polygoni Multiflori, Radix Sanguisorbae, Herba Polygoni Perfoliati, Herba Tropaeoli, Fructus Forsythiae, Herba Lycopodii, Herba Andrographis, Cortex Betulae Luminiferae, Herba Centellae, Herba Spirodelae, Radix Scutellariae, Folium pterocaryae stenopterae, Rhizoma Smilacis Chinensis, Radix Arnebiae (Radix Lithospermi) and Flos Hibisci Mutabilis.Or its combination.
Usually, the consumption of these extra external preparation for skin medical materials is as follows:
The content of the complementary medical material of table 2
| Medical material | Content | Preferred content | Optimum content |
| Fructus Anisi Stellati | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Herba Chenopodii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Folium eucalypti globueli (Eucalyptus globulus Labill.) | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| The Folium Ligustri Lucidi | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Folium Hibisci Mutabilis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Herba Moslae Chinensis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Fructus Liquidambaris | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Herba Caryopteridis Incanae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Salviae Miltiorrhizae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Herba Lobeliae Chinensis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Radix Polygoni Multiflori | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Sanguisorbae | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Polygoni Perfoliati | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Tropaeoli | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Fructus Forsythiae | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Herba Lycopodii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Andrographis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Cortex Betulae Luminiferae | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Centellae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Herba Spirodelae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Scutellariae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Folium pterocaryae stenopterae | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Rhizoma Smilacis Chinensis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Radix Arnebiae (Radix Lithospermi) | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Flos Hibisci Mutabilis | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
A kind of preferred extract of the present invention is in order to medical material mixture preparation down, and this mixture contains:
The preferred medical material proportioning of table 3
| Medical material | Content | Preferred content | Optimum content |
| Herba Solidaginis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Flos Caryophylli | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| The Radix Stemonae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Semen Vaccariae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Cortex Hibisci | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Radix Ilicis Pubescentis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Radix Glycyrrhizae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Cortex Dictamni | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Angelicae Sinensis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Flos Carthami | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Spina Gleditsiae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Ramulus Uncariae Cum Uncis | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Radix Cynanchi Paniculati | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Rhizoma Dioscoreae | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Fructus Anisi Stellati | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Herba Chenopodii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Folium eucalypti globueli (Eucalyptus globulus Labill.) | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| The Folium Ligustri Lucidi | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Folium Hibisci Mutabilis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Herba Moslae Chinensis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Fructus Liquidambaris | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Herba Caryopteridis Incanae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Salviae Miltiorrhizae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Herba Lobeliae Chinensis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Radix Polygoni Multiflori | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Sanguisorbae | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Polygoni Perfoliati | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Tropaeoli | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Fructus Forsythiae | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
| Herba Lycopodii | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Andrographis | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Cortex Betulae Luminiferae | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Herba Centellae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Herba Spirodelae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Radix Scutellariae | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Folium pterocaryae stenopterae | 0.3-6 weight portion | 0.5-5 weight portion | 1-4.5 weight portion |
| Rhizoma Smilacis Chinensis | 0.5-8 weight portion | The 1-6 weight portion | The 2-5 weight portion |
| Radix Arnebiae (Radix Lithospermi) | 0.2-4 weight portion | 0.5-3 weight portion | The 1-3 weight portion |
| Flos Hibisci Mutabilis | 0.1-2 weight portion | 0.2-1.8 weight portion | 0.5-1.5 weight portion |
Preparation method
The available following method preparation of active component of the present invention (being the extract of medical material): with required medical material (or medical material mixture) water or contain the suitable mixable organic solvent of water of 30-85% (v/v) as alcohol (preferred alcohol) extracting, filter the extract that obtains so then, can randomly filtrate be carried out drying with conventional method (as spray drying, lyophilizing or concentrate drying) then.Active component of the present invention can mix the extract of extractive each raw medicinal material respectively and prepare, and also can obtain by the mixture of extracting medical material.
Extracting can be carried out under room temperature or heating condition, but preferably at 4-35 ℃, more preferably carries out under 5-30 ℃.
The extractive time is not particularly limited, and is generally more than 1 hour, and for example 0.5-50 days more preferably is 1-30 days.
In another preference, can in the liquid extract that makes, add solubilizing agent (as polyoxyethylene groups), antioxidant (as sodium thiosulfate), surfactant (as sodium laurylsulfate) and/or antiseptic (as sodium benzoate), make the compositions of liquid state of the present invention, as spray.
In another preference, can in the liquid extract that makes, add greasing base (as vaseline), water-soluble base (as Polyethylene Glycol), emulsion-type substrate (as Polysorbate), antioxidant (as sodium thiosulfate) and/or antiseptic (as sodium benzoate), make the compositions of liquid state of the present invention, as ointment, ointment.
In another preference, can in the liquid extract that makes, add solvent (as water, ethanol, vegetable oil), plasticizer (as glycerol) and/or filmogen (as polyvinyl alcohol), make the compositions of liquid state of the present invention, as liniment, lotion, liniment.
In another preference, can in the liquid extract that makes, add gel-type vehicle (as carbomer, liquid paraffin), make the compositions of liquid state of the present invention, as gel.
Usually, extract of the present invention is mixed with suitable carriers can obtain compositions of the present invention.The method that can be used for preparing the present composition is not particularly limited, and the various conventional methods of available this area are as mixing method etc.
In preparation of the present invention, the extract that contains the above-mentioned raw materials medical material is as active component and pharmaceutically acceptable carrier or additives.
As used herein, term " compositions of the present invention " comprises pharmaceutical composition and composition for external application (as shampoo or hair products), as long as they contain Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.The water extract or the extract of aqueous organic solvent or basically by Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.Extract Deng raw medicinal material constitutes.In compositions, Herba Solidaginis of the present invention, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.Or Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.Account for the 0.02-99% of composition total weight with the extract of other auxiliary medical materials, preferably account for 1-90%, account for 5-80% best.
In addition, press the dry weight of medical material and calculate, every milliliter of fluid composition should restrain corresponding to 0.01-10, more preferably restrains total dried medical material corresponding to 0.05-5, restrains total dried medical material corresponding to 0.1-2.5 best.
As used herein, term " pharmaceutically acceptable carrier " refers to be used to can be used for the carrier of medicine.This term refers to some carriers like this: they itself are not necessary active component, and do not have undue toxicity after using.Suitable carriers is well known to those of ordinary skill in the art.Acceptable carrier can contain liquid on combination of Chinese medicine is learned, as water, saline, glycerol and ethanol.In addition, also may there be complementary material in these carriers, as wetting agent or emulsifying agent, pH buffer substance etc.
Compositions of the present invention also can contain at least a pharmaceutically acceptable additive, for example correctives, spice, pigment etc.These additives all are to know in this area.
Purposes and using method
Extract of the present invention or compositions can be used for treating dermatosis such as psoriasis, herpes zoster, neurodermatitis.When using, can use, comprising (but being not limited to): be sprayed on, be applied to, smear on skin by conventional route.
When using compositions provided by the invention, be Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae with safe and effective amount.(or Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.Mixture with other auxiliary medical materials) the water extract or the extract of aqueous organic solvent are applied to the people.Wherein this safe and effective amount is generally everyone 0.01-100 gram, preferably for the 0.05-50 gram, presses Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.(or Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.Mixture with other auxiliary medical materials) dried medical material amount meter.Certainly, concrete dosage also should be considered the factors such as health of method of application, subject, and these all are within the skill of this area.
Major advantage of the present invention is:
1, various skin diseases such as psoriasis, herpes zoster, neurodermatitis there is the obvious treatment effect;
2, pure natural components, safer, side effect is little.
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.The experimental technique of unreceipted actual conditions in the following example is usually according to the normal condition or the condition of advising according to manufacturer.Unless otherwise indicated, otherwise all percentage ratio and umber by weight.
Unless otherwise defined, the same meaning that employed all specialties and scientific words and one skilled in the art are familiar with in the literary composition.In addition, any method similar or impartial to described content and material all can be applicable in the inventive method.The usefulness that preferable implementation method described in the literary composition and material only present a demonstration.
Preparation embodiment 1-4
Take by weighing the raw medicinal material of following quantity,
| Embodiment 1 consumption (kilogram) | Embodiment 2 consumptions (kilogram) | Embodiment 3 consumptions (kilogram) | Embodiment 4 consumptions (kilogram) | |
| Herba Solidaginis | 0.5 | 6 | 8 | 4 |
| Flos Caryophylli | 0.5 | 6 | 8 | 2 |
| The Radix Stemonae | 0.5 | 6 | 8 | 4 |
| Semen Vaccariae | 0.5 | 6 | 8 | 4 |
| Cortex Hibisci | 0.5 | 6 | 8 | 5 |
| Radix Ilicis Pubescentis | 0.3 | 5 | 6 | 3 |
| Radix Glycyrrhizae | 0.2 | 1 | 4 | 2 |
| Cortex Dictamni | 0.2 | 1 | 4 | 2 |
| Radix Angelicae Sinensis | 0.5 | 1 | 8 | 3 |
| Flos Carthami | 0.2 | 2 | 4 | 2 |
| Spina Gleditsiae | 0.2 | 2 | 4 | 2 |
| Ramulus Uncariae Cum Uncis | 0.1 | 1 | 1 | 1 |
| Radix Cynanchi Paniculati | 0.5 | 4 | 8 | 3 |
| Rhizoma Dioscoreae | 0.5 | 4 | 8 | 3 |
Clean, dry, be crushed to Powdered (mean diameter is about 250-500 μ m).Placing the bottom that the column shape container (solvent flows through the medicated powder on the dividing plate from top to bottom) of dividing plate is arranged in powder, is that 40% (v/v) ethanol water is solvent (consumption is 10 times of each medical material gross dry weight) with concentration.Medical material flooded 48 hours with solvent, filtered then, collected filtrate and obtained liquid extract.
In liquid extract, add polyoxyethylene groups, sodium thiosulfate, sodium laurylsulfate and sodium benzoate to 0.5wt%.Make spray a, b, c and d respectively, each 1000 milliliters, close 1 gram medical material/1ml.
Preparation embodiment 5-8
Repeat to prepare the method for embodiment 1-4, difference is: also additionally contain in the medical material mixture
| Embodiment 5 consumptions (kilogram) | Embodiment 6 consumptions (kilogram) | Embodiment 7 consumptions (kilogram) | Embodiment 8 consumptions (kilogram) | |
| Fructus Anisi Stellati | 0.2-4 | 3 | 2 | 0 |
| Herba Chenopodii | 0.3-6 | 5 | 3 | 3 |
| Folium eucalypti globueli (Eucalyptus globulus Labill.) | 0.3-6 | 5 | 4 | 3 |
| The Folium Ligustri Lucidi | 0.5-8 | 6 | 4 | 4 |
| Folium Hibisci Mutabilis | 0.5-8 | 6 | 1 | 4 |
| Herba Moslae Chinensis | 0.5 | 6 | 4 | 4 |
| Fructus Liquidambaris | 0.1 | 1 | 1 | 1 |
| Herba Caryopteridis Incanae | 0.2 | 3 | 2 | 2 |
| Radix Salviae Miltiorrhizae | 0.2 | 3 | 2 | 2 |
| Herba Lobeliae Chinensis | 0.3 | 5 | 3 | 3 |
| Radix Polygoni Multiflori | 0.2 | 3 | 2 | 2 |
| Radix Sanguisorbae | 0.3 | 5 | 0 | 3 |
| Herba Polygoni Perfoliati | 0.3 | 5 | 3 | 3 |
| Herba Tropaeoli | 0.2 | 1.5 | 1 | 1 |
| Fructus Forsythiae | 0.2 | 1.5 | 1 | 1 |
| Herba Lycopodii | 0.3 | 0 | 3 | 3 |
| Herba Andrographis | 0.3 | 5 | 3 | 3 |
| Cortex Betulae Luminiferae | 0.3 | 5 | 3 | 3 |
| Herba Centellae | 0.2 | 3 | 2 | 2 |
| Herba Spirodelae | 0.2 | 3 | 2 | 2 |
| Radix Scutellariae | 0.2 | 3 | 2 | 2 |
| Folium pterocaryae stenopterae | 0.3 | 5 | 0 | 3 |
| Rhizoma Smilacis Chinensis | 0.5 | 6 | 0 | 4 |
| Radix Arnebiae (Radix Lithospermi) | 0.2 | 3 | 0 | 2 |
| Flos Hibisci Mutabilis | 0.2 | 1.5 | 0 | 1 |
Make spray e, f, g and h respectively.
Preparation embodiment 9-12
Repeat embodiment 5-8, difference is pharmaceutical composition is made ointment, and wherein every gram ointment contains corresponding to the dried medical material of 0.1 gram.
Test implementation example 1
Treatment eczema
The spray a that uses embodiment 1 to make for 5 eczema patients, every day 2-3 time is at every turn with drip degree of being not.Average 1 day takes effect, the back healing of 1 week.
The result shows that compositions provided by the invention has the effect of treatment eczema.
Test implementation example 2
The treatment psoriasis
Give 3 spray b that the psoriatic uses embodiment 2 to make, every day three times is at every turn with drip degree of being not.Take effect after average 1 week, scurf obviously alleviates with scratching where it itches, and skin appearance approached normally in average 3 months.
The result shows that compositions provided by the invention has the psoriasic effect of treatment.
Test implementation example 3
The treatment neurodermatitis
Give 5 spray c that the neurodermatitis patient uses embodiment 3 to make, at every turn with drip degree of being not.Take effect after average 2 days, scratching where it itches alleviates, and cures in average 2 months.
The result shows that compositions provided by the invention has the effect of treatment neurodermatitis.
Test implementation example 4
The treatment herpes zoster
The spray d that uses embodiment 4 to make for 3 bit strip shape herpes patients, every day three times is at every turn with drip degree of being not.Take effect after average 3 days, pain alleviates, and cures in average 1 month.
The result shows that compositions provided by the invention has the effect of treatment herpes zoster.
Test implementation example 5
The spray e that uses embodiment 5 to make respectively is respectively applied for eczema patients, and usage is with test implementation example 1.
The result shows that the effect of this spray e is similar to preparation a, can make the remission or the disappearance of eczema.
Test implementation example 6-8
Spray f, the g and the h that use embodiment 6-8 to make respectively are respectively applied for psoriasis, herpes zoster, neurodermatitis patient, and usage is with test implementation example 2-4.
The result shows that the effect of this spray e is similar to preparation b-d, can make the remission or the disappearance of psoriasis, herpes zoster, neurodermatitis.
The above only is preferred embodiment of the present invention, be not in order to limit essence technology contents scope of the present invention, essence technology contents of the present invention is broadly to be defined in the claim scope of application, any technology entity or method that other people finish, if it is defined identical with the claim scope of application, also or a kind of change of equivalence, all will be regarded as being covered by among this claim scope.
Claims (10)
1. compositions, it contains (a) pharmaceutically acceptable carrier and (b) water extract of the raw medicinal material of effective dose or the extract of aqueous organic solvent, and described raw medicinal material comprises Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae;
And the extract of described medical material accounts for the 0.02-99% of composition total weight.
2. compositions as claimed in claim 1, described raw medicinal material also comprise one or more complementary raw medicinal materials that are selected from down group: Fructus Anisi Stellati, Herba Chenopodii, Folium eucalypti globueli (Eucalyptus globulus Labill.), the Folium Ligustri Lucidi, Folium Hibisci Mutabilis, Herba Moslae Chinensis, Fructus Liquidambaris, Herba Caryopteridis Incanae, Radix Salviae Miltiorrhizae, Herba Lobeliae Chinensis, Radix Polygoni Multiflori, Radix Sanguisorbae, Herba Polygoni Perfoliati, Herba Tropaeoli, Fructus Forsythiae, Herba Lycopodii, Herba Andrographis, Cortex Betulae Luminiferae, Herba Centellae, Herba Spirodelae, Radix Scutellariae, Folium pterocaryae stenopterae, Rhizoma Smilacis Chinensis, Radix Arnebiae (Radix Lithospermi) and Flos Hibisci Mutabilis.
3. compositions as claimed in claim 1, described medical material comprises:
0.5-8 weight portion Herba Solidaginis;
0.5-8 weight portion Flos Caryophylli;
0.5-8 the weight portion Radix Stemonae;
0.5-8 weight portion Semen Vaccariae;
0.5-8 weight portion Cortex Hibisci;
0.3-6 weight portion Radix Ilicis Pubescentis;
0.2-4 weight portion Radix Glycyrrhizae;
0.2-4 weight portion Cortex Dictamni;
0.5-8 weight portion Radix Angelicae Sinensis;
0.2-4 weight portion Flos Carthami;
0.2-4 weight portion Spina Gleditsiae;
0.1-2 weight portion Ramulus Uncariae Cum Uncis;
0.5-8 weight portion Radix Cynanchi Paniculati; With
0.5-8 weight portion Rhizoma Dioscoreae.
4. compositions as claimed in claim 3, described compositions also comprise one or more medical materials that are selected from down group:
0.2-4 weight portion Fructus Anisi Stellati;
0.3-6 weight portion Herba Chenopodii;
0.3-6 weight portion Folium eucalypti globueli (Eucalyptus globulus Labill.);
0.5-8 the weight portion Folium Ligustri Lucidi;
0.5-8 weight portion Folium Hibisci Mutabilis;
0.5-8 weight portion Herba Moslae Chinensis;
0.1-2 weight portion Fructus Liquidambaris;
0.2-4 weight portion Herba Caryopteridis Incanae;
0.2-4 weight portion Radix Salviae Miltiorrhizae;
0.3-6 weight portion Herba Lobeliae Chinensis;
0.2-4 weight portion Radix Polygoni Multiflori;
0.3-6 weight portion Radix Sanguisorbae;
0.3-6 weight portion Herba Polygoni Perfoliati;
0.1-2 weight portion Herba Tropaeoli;
0.1-2 weight portion Fructus Forsythiae;
0.3-6 weight portion Herba Lycopodii;
0.3-6 weight portion Herba Andrographis;
0.3-6 weight portion Cortex Betulae Luminiferae;
0.2-4 weight portion Herba Centellae;
0.2-4 weight portion Herba Spirodelae;
0.2-4 weight portion Radix Scutellariae;
0.3-6 weight portion Folium pterocaryae stenopterae;
0.5-8 weight portion Rhizoma Smilacis Chinensis;
0.2-4 weight portion Radix Arnebiae (Radix Lithospermi);
0.1-2 weight portion Flos Hibisci Mutabilis.
5. compositions as claimed in claim 4, described crude drug contains:
1-6 weight portion Herba Solidaginis;
1-6 weight portion Flos Caryophylli;
The 1-6 weight portion Radix Stemonae;
1-6 weight portion Semen Vaccariae;
1-6 weight portion Cortex Hibisci;
0.5-5 weight portion Radix Ilicis Pubescentis;
0.5-3 weight portion Radix Glycyrrhizae;
0.5-3 weight portion Cortex Dictamni;
1-6 weight portion Radix Angelicae Sinensis;
0.5-3 weight portion Flos Carthami;
0.5-3 weight portion Spina Gleditsiae;
0.2-1.8 weight portion Ramulus Uncariae Cum Uncis;
1-6 weight portion Radix Cynanchi Paniculati;
1-6 weight portion Rhizoma Dioscoreae.
6. as the arbitrary described compositions of claim 1-5, described compositions is spray, ointment, ointment, liniment, lotion or gel.
7. one kind prepares method for compositions as claimed in claim 1, and described method comprises step:
(i) described medical material was mixed 0.5-50 days with water or aqueous organic solvent, form mixed liquor;
(ii) filter mixed liquor, obtain filtrate, thereby obtain extract;
(iii) extract is mixed with pharmaceutically acceptable carrier, form compositions;
Perhaps
Described method comprises that the aqueous extract with each medical material mixes, and forms and extracts mixture, will extract mixture again and mix with pharmaceutically acceptable carrier, forms compositions.
8. method as claimed in claim 7, described raw medicinal material also contain one or more complementary raw medicinal materials that are selected from down group: Fructus Anisi Stellati, Herba Chenopodii, Folium eucalypti globueli (Eucalyptus globulus Labill.), the Folium Ligustri Lucidi, Folium Hibisci Mutabilis, Herba Moslae Chinensis, Fructus Liquidambaris, Herba Caryopteridis Incanae, Radix Salviae Miltiorrhizae, Herba Lobeliae Chinensis, Radix Polygoni Multiflori, Radix Sanguisorbae, Herba Polygoni Perfoliati, Herba Tropaeoli, Fructus Forsythiae, Herba Lycopodii, Herba Andrographis, Cortex Betulae Luminiferae, Herba Centellae, Herba Spirodelae, Radix Scutellariae, Folium pterocaryae stenopterae, Rhizoma Smilacis Chinensis, Radix Arnebiae (Radix Lithospermi) and Flos Hibisci Mutabilis.
9. the purposes of a Chinese medicine medicinal material composition or its aqueous extract, wherein, described Chinese medicine medicinal material composition comprises: Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae, it is characterized in that described Chinese medicine medicinal material composition or its aqueous extract are used to prepare composition for external application.
10. the aqueous extract of a Chinese medicine medicinal material composition or water extract, described Chinese medicine medicinal material composition comprises: Herba Solidaginis, Flos Caryophylli, the Radix Stemonae, Semen Vaccariae, Cortex Hibisci, Radix Ilicis Pubescentis, Radix Glycyrrhizae, Cortex Dictamni, Radix Angelicae Sinensis, Flos Carthami, Spina Gleditsiae, Ramulus Uncariae Cum Uncis, Radix Cynanchi Paniculati and Rhizoma Dioscoreae.
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| CNA2007100374601A CN101244221A (en) | 2007-02-13 | 2007-02-13 | Composition for external application and preparation method |
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| CNA2007100374601A CN101244221A (en) | 2007-02-13 | 2007-02-13 | Composition for external application and preparation method |
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