CN104306757A - Traditional Chinese medicine composition for preventing and treating sheep stomatitis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for preventing and treating sheep stomatitis and preparation method thereof Download PDF

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Publication number
CN104306757A
CN104306757A CN201410504272.5A CN201410504272A CN104306757A CN 104306757 A CN104306757 A CN 104306757A CN 201410504272 A CN201410504272 A CN 201410504272A CN 104306757 A CN104306757 A CN 104306757A
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China
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weight portion
radix
herba
chinese medicine
medicine composition
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CN201410504272.5A
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吕尊周
吕明斌
燕磊
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Shandong New Hope Liuhe Group Co Ltd
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Shandong New Hope Liuhe Group Co Ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/413—Gall bladder; Bile
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    • A61K35/56—Materials from animals other than mammals
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating sheep stomatitis and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw herbal materials: honeysuckle, forsythia, andrographis, folium isatidis, natural indigo, dandelion, Chinese violet, wild chrysanthemum, rhizoma smilacis glabrae, houttuynia, cohosh, mongolian snakegourd root, lithospermum purpurocaeruleum, lophatherum gracile, cortex phellodendri, cortex dictamni, meadowrue root and rhizome, circium japonicum, common cephalanoplos herb, garden burnet root, ramie root, bezoar, pearl, ferrosic oxide, borneol, potentilla freyniana, manystem stonecrop leaf, yarrow, assam crotalaria root, entada phaseoloides and hibiscus root. The traditional Chinese medicine composition for treating sheep stomatitis provided by the invention has the beneficial effects of mainly clearing away heat and toxic materials, and eliminating sore and reliving pain to diminish inflammation, sterilize and prevent virus, heal sores, prevent infection, and control state of an illness, supplementarily tranquilizing mind by nourishing the heart and treating yin deficiency by reinforcing body fluid to enhance immunity of sheep, and uneasily producing drug resistance due to low drug residues; the Chinese herbal medicines are selected, the cost price is low, and the administration is convenient.

Description

A kind of Chinese medicine composition for preventing and treating sheep stomatitis and preparation method thereof
Technical field
The present invention relates to herbal medicine technical field, particularly a kind of Chinese medicine composition for preventing and treating sheep stomatitis and preparation method thereof.
Background technology
Sheep stomatitis is the inflammation of oral mucosa top layer and deep tissues.In pathological process, oral mucosa and gingival inflammation, disease sheep can be made to search for food and dysmasesis, and watery saliva flowing from the mouth, sensitivity to pain increases.Clinical common pure local inflammation and Secondary cases general reaction.
The cause of disease: constitutional stomatitis is many to be caused by wound, sheep can because searching for food plant branch sharp-pointed, straw stabs oral cavity and falls ill, also can because of contact ammonia, strong acid, highly basic, lesion ports mucosa and falling ill.When sheep suffers from aphtha, foot and mouth disease, sheep pox thrush, also stomatitis symptom can be there is.
Chinese veterinarian thinks that sheep stomatitis belongs to the one of " skin infection ", the paathogenic factor of skin infection, has diseases caused by exogenous pathogenic factor (diseases caused by exogenous pathogenic factor six climate exopathogens evil poison, experience special poison, external injury etc.) and internal injury (feelings will internal injury, eating and drinking without temperance, chamber damage etc.) two large classes.The skin infection that exopathogen causes, the most common with " pyretic toxicity ", " fire-toxin ", the skin infection that wind and cold heat-damp in summer etc. causes, have in the initial phase, and not all there is the red heat phenomenon of pyretic toxicity, fire-toxin, in out of contior situation, sick to mid-term, just can manifest.This kind of skin infection generally all has the feature of YANG syndrome skin infection, because after skin infection occurs, pathological process is development and change, and the final performance of skin infection, is mostly pyretic toxicity, the resembling of fire-toxin.More the skin infection that internal injury causes, mostly because void is caused a disease, and belong to chronic, as network sky of suffering from a deficiency of the kidney, easily form the tuberculosis of bone and joint for the turbid invasion and attack of wind and cold expectorant; Deficiency of YIN of both the lung and kidney, hyperactivity of deficient fire, bright Tianjin be expectorant form this kind of skin infection of scrofula just, there is mid-term the feature of YIN syndrome skin infection more.The skin infection no matter that a kind of paathogenic factor causes, all can cause local and a series of pathological reaction of whole body.
Doctor trained in Western medicine control sheep stomatitis clinical treatment is longer for the course for the treatment of, clinical therapeutic efficacy is not satisfactory, prolonged application antibiotic easily produces drug resistance, and there is no the effect of prevention infection, occur more toxic and side effects, such as haematological toxicity reaction, Liver and kidney toxic reaction, gastrointestinal reactions etc., the in a short time wayward state of an illness, can delay treatment etc.
But Chinese medicine prevention sheep stomatitis, not only can make up the deficiency of doctor trained in Western medicine, can anti-inflammation and sterilization antiviral, healing skin infection, prevention infection, symptom management, strengthens the immunity of sheep, and low drug residue, not easily produces drug resistance.Selected Chinese medicinal material, cost price is cheap, convenient drug administration, is applicable to carrying out marketing.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for preventing and treating sheep stomatitis, adopt this Chinese medicine composition can overcome the defect of prior art Chinese medicine and western medicine and Chinese medicine, treatment sheep stomatitis, heat-clearing and toxic substances removing, the skin ulcer that disappears pain relieving, can anti-inflammation and sterilization antiviral, healing skin infection, prevention infection, symptom management, strengthen the immunity of sheep, and low drug residue, not easily produce drug resistance; Selected Chinese medicinal material, cost price is cheap, convenient drug administration.
In order to realize foregoing invention object; the invention provides a kind of Chinese medicine composition for preventing and treating sheep stomatitis, described Chinese medicine composition comprises following raw medicinal material: Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Indigo Naturalis, Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Smilacis Glabrae, Herba Houttuyniae, Rhizoma Cimicifugae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Herba Lophatheri, Cortex Phellodendri, Cortex Dictamni, Radix et Rhizoma Thalictri, Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Radix Boehmeriae, Calculus Bovis, Margarita, the pig iron fall, Borneolum Syntheticum, Herba Potentillae Freynianae, Herba Sedi Multicaulis, Achillea millefolium L., Caulis et Folium Crotalariae Assamicae, Caulis Endadae phaseoloidis and Radix abelmoschi manihot.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 21-36 weight portion, Fructus Forsythiae 10-25 weight portion, Herba Andrographis 13-26 weight portion, Folium Isatidis 23-35 weight portion, Indigo Naturalis 14-24 weight portion, Herba Taraxaci 17-34 weight portion, Herba Violae 20-34 weight portion, Flos Chrysanthemi Indici 21-32 weight portion, Rhizoma Smilacis Glabrae 16-28 weight portion, Herba Houttuyniae 13-27 weight portion, Rhizoma Cimicifugae 23-35 weight portion, Radix Trichosanthis 25-39 weight portion, Radix Arnebiae (Radix Lithospermi) 14-30 weight portion, Herba Lophatheri 20-33 weight portion, Cortex Phellodendri 13-27 weight portion, Cortex Dictamni 17-29 weight portion, Radix et Rhizoma Thalictri 8-19 weight portion, Radix Cirsii Japonici 21-37 weight portion, Herba Cirsii 16-30 weight portion, Radix Sanguisorbae 12-26 weight portion, Radix Boehmeriae 14-33 weight portion, Calculus Bovis 21-36 weight portion, Margarita 24-38 weight portion, the pig iron falls 17-37 weight portion, Borneolum Syntheticum 5-13 weight portion, Herba Potentillae Freynianae 17-31 weight portion, Herba Sedi Multicaulis 13-28 weight portion, Achillea millefolium L. 10-25 weight portion, Caulis et Folium Crotalariae Assamicae 4-10 weight portion, Caulis Endadae phaseoloidis 3-8 weight portion and Radix abelmoschi manihot 16-27 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 23 weight portion, Fructus Forsythiae 15 weight portion, Herba Andrographis 16 weight portion, Folium Isatidis 27 weight portion, Indigo Naturalis 17 weight portion, Herba Taraxaci 23 weight portion, Herba Violae 31 weight portion, Flos Chrysanthemi Indici 29 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Houttuyniae 18 weight portion, Rhizoma Cimicifugae 32 weight portion, Radix Trichosanthis 35 weight portion, Radix Arnebiae (Radix Lithospermi) 16 weight portion, Herba Lophatheri 30 weight portion, Cortex Phellodendri 23 weight portion, Cortex Dictamni 17 weight portion, Radix et Rhizoma Thalictri 11 weight portion, Radix Cirsii Japonici 24 weight portion, Herba Cirsii 26 weight portion, Radix Sanguisorbae 14 weight portion, Radix Boehmeriae 28 weight portion, Calculus Bovis 23 weight portion, Margarita 31 weight portion, the pig iron falls 17 weight portions, Borneolum Syntheticum 11 weight portion, Herba Potentillae Freynianae 17 weight portion, Herba Sedi Multicaulis 25 weight portion, Achillea millefolium L. 10 weight portion, Caulis et Folium Crotalariae Assamicae 8 weight portion, Caulis Endadae phaseoloidis 3 weight portion and Radix abelmoschi manihot 18 weight portion.
Described Chinese medicine composition also comprises red palpus palpus, Rhizoma Arisaematis, Ziziphora bungeana Juz., Radix Rosae Bracteatae and the Receptaculum Fici Pumilae.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 21-36 weight portion, Fructus Forsythiae 10-25 weight portion, Herba Andrographis 13-26 weight portion, Folium Isatidis 23-35 weight portion, Indigo Naturalis 14-24 weight portion, Herba Taraxaci 17-34 weight portion, Herba Violae 20-34 weight portion, Flos Chrysanthemi Indici 21-32 weight portion, Rhizoma Smilacis Glabrae 16-28 weight portion, Herba Houttuyniae 13-27 weight portion, Rhizoma Cimicifugae 23-35 weight portion, Radix Trichosanthis 25-39 weight portion, Radix Arnebiae (Radix Lithospermi) 14-30 weight portion, Herba Lophatheri 20-33 weight portion, Cortex Phellodendri 13-27 weight portion, Cortex Dictamni 17-29 weight portion, Radix et Rhizoma Thalictri 8-19 weight portion, Radix Cirsii Japonici 21-37 weight portion, Herba Cirsii 16-30 weight portion, Radix Sanguisorbae 12-26 weight portion, Radix Boehmeriae 14-33 weight portion, Calculus Bovis 21-36 weight portion, Margarita 24-38 weight portion, the pig iron falls 17-37 weight portion, Borneolum Syntheticum 5-13 weight portion, Herba Potentillae Freynianae 17-31 weight portion, Herba Sedi Multicaulis 13-28 weight portion, Achillea millefolium L. 10-25 weight portion, Caulis et Folium Crotalariae Assamicae 4-10 weight portion, Caulis Endadae phaseoloidis 3-8 weight portion, Radix abelmoschi manihot 16-27 weight portion, red palpus palpus 6-12 weight portion, Rhizoma Arisaematis 8-14 weight portion, Ziziphora bungeana Juz. 9-16 weight portion, Radix Rosae Bracteatae 11-17 weight portion and Receptaculum Fici Pumilae 3-7 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 23 weight portion, Fructus Forsythiae 15 weight portion, Herba Andrographis 16 weight portion, Folium Isatidis 27 weight portion, Indigo Naturalis 17 weight portion, Herba Taraxaci 23 weight portion, Herba Violae 31 weight portion, Flos Chrysanthemi Indici 29 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Houttuyniae 18 weight portion, Rhizoma Cimicifugae 32 weight portion, Radix Trichosanthis 35 weight portion, Radix Arnebiae (Radix Lithospermi) 16 weight portion, Herba Lophatheri 30 weight portion, Cortex Phellodendri 23 weight portion, Cortex Dictamni 17 weight portion, Radix et Rhizoma Thalictri 11 weight portion, Radix Cirsii Japonici 24 weight portion, Herba Cirsii 26 weight portion, Radix Sanguisorbae 14 weight portion, Radix Boehmeriae 28 weight portion, Calculus Bovis 23 weight portion, Margarita 31 weight portion, the pig iron falls 17 weight portions, Borneolum Syntheticum 11 weight portion, Herba Potentillae Freynianae 17 weight portion, Herba Sedi Multicaulis 25 weight portion, Achillea millefolium L. 10 weight portion, Caulis et Folium Crotalariae Assamicae 8 weight portion, Caulis Endadae phaseoloidis 3 weight portion, Radix abelmoschi manihot 18 weight portion, red palpus palpus 7 weight portions, Rhizoma Arisaematis 9 weight portion, Ziziphora bungeana Juz. 11 weight portion, Radix Rosae Bracteatae 15 weight portion and the Receptaculum Fici Pumilae 4 weight portion.
The dosage form of described Chinese medicine composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
The dosage form of described Chinese medicine composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
In order to better realize foregoing invention object, the invention provides a kind of preparation method of the Chinese medicine composition for preventing and treating sheep stomatitis, the dosage form of described Chinese medicine composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
In order to better realize foregoing invention object, the invention provides a kind of preparation method of the Chinese medicine composition for preventing and treating sheep stomatitis, the dosage form of described Chinese medicine composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
The invention has the beneficial effects as follows: traditional Chinese medicine composition for treating sheep stomatitis of the present invention is with heat-clearing and toxic substances removing, the skin ulcer that disappears pain relieving is main, can anti-inflammation and sterilization antiviral, healing skin infection, prevention infection, symptom management, with tranquilizing by nourishing the heart, replenishing kidney-YIN is auxiliary, strengthens the immunity of sheep, and low drug residue, not easily produce drug resistance; Selected Chinese medicinal material, cost price is cheap, convenient drug administration.
Detailed description of the invention
Chinese veterinarian thinks, the treatment of skin infection divides treatment by oral administration of medicines and external treatment, the two normal connected applications.Large, critical skin infection disease, as septicemia, caves in, not only needs treatment by oral administration of medicines, external treatment to combine.The general provisions of skin infection internal treatment are for disappearing, holding in the palm, mend.When initial stage not yet becomes pus, make it to dissipate with resolving therapy, and use heat-clearing and toxic substances removing and battalion clots absorbing, circulation of qi promoting for the cause of disease, the state of an illness, induce sweat, the rule such as Wen Tong, Tongli, reason are wet, wherein heat-clearing and toxic substances removing is the most frequently used method for the treatment of of skin infection; Mid-term difficulty in discharging of pus or pus go out smooth, with expelling pathogens by strengthening vital QI with eliminating the toxic material out by tonification, expelling pathogens by strengthening vital QI divides again promoting pus-drainage by orally taking medicine and therapy of dispersion by invigorating; Later stage deficiency of vital QI person, recovers healthy energy by reinforcement, and the open sore part is healed early, usually has QI invigorating, nourishes blood, YIN nourishing, the rule such as supporing yang.According to whole body and local circumstance, by the change and progress of the state of an illness, principal contradiction should be caught, establishment of the therapeutic methods and Applying Medicine when specifically treating.Skin infection external treatment should, intermediary and later stages respectively diagnosis and prescription first according to skin infection.
Therefore, for the corresponding symptom that ill sheep occurs, the invention provides a kind of with heat clearing away solution, the skin ulcer that disappears pain relieving is primary treatment principle, and treatment sheep stomatitis Chinese medicine composition comprises: Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Indigo Naturalis, Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Smilacis Glabrae, Herba Houttuyniae, Rhizoma Cimicifugae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Herba Lophatheri, Cortex Phellodendri, Cortex Dictamni, Radix et Rhizoma Thalictri, Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Radix Boehmeriae, Calculus Bovis, Margarita, the pig iron fall, Borneolum Syntheticum, Herba Potentillae Freynianae, Herba Sedi Multicaulis, Achillea millefolium L., Caulis et Folium Crotalariae Assamicae, Caulis Endadae phaseoloidis and Radix abelmoschi manihot; Preferably can also comprise red palpus palpus, Rhizoma Arisaematis, Ziziphora bungeana Juz., Radix Rosae Bracteatae, the Receptaculum Fici Pumilae.
Wherein, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Indigo Naturalis, Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Smilacis Glabrae, Herba Houttuyniae, Rhizoma Cimicifugae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Herba Lophatheri, Herba Potentillae Freynianae, Herba Sedi Multicaulis, Achillea millefolium L. and Caulis et Folium Crotalariae Assamicae clearing away heat-fire, removing toxic substances, loose carbuncle detumescence; Cortex Phellodendri, Cortex Dictamni, Radix et Rhizoma Thalictri heat clearing and damp drying, eliminating fire and detoxication of holding concurrently; Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Radix Rumicis Japonici, Radix Boehmeriae cooling blood for hemostasis, removing toxic substances sore; Calculus Bovis, Margarita, the pig iron fall, Borneolum Syntheticum heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing; Caulis Endadae phaseoloidis and Radix abelmoschi manihot pain relieving; Red palpus palpus, Rhizoma Arisaematis and Ziziphora bungeana Juz. tranquilizing by nourishing the heart; Radix Rosae Bracteatae and Receptaculum Fici Pumilae the kidney invigorating; Full side's compatibility science, rigorous, can anti-inflammation and sterilization antiviral, healing skin infection, prevention infection, symptom management, strengthens the immunity etc. of sheep.
The pharmacology of each crude drug is as follows:
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp.There is heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cure mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.
Fructus Forsythiae: bitter in the mouth, cold nature; Enter the heart, lung, small intestine meridian.The pharmacological action such as have antibacterial, heart tonifying, diuresis, town to tell is the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, the symptom such as laryngopharynx swelling and pain, acute nephritis, carbuncle sore tumefacting virus.
Herba Andrographis: bitter, cold.GUIXIN, lung, large intestine, urinary bladder channel.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.
Folium Isatidis: bitter, cold; Enter liver, the heart, stomach warp.Control pestilence pyretic toxicity to go mad, wind heat macule, carbuncle and ulcer swells and ache, relieving thirst and restlessness, only epistaxis, haematemesis, kills infantile malnutrition erosion, incised wound curare.Heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel.There is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire, send out the cards such as all cards of pyretic toxicity such as speckle, haematemesis, laryngopharynx swelling and pain, herpes eczema, liver-fire invading the lung, cough chest pain, sputum mixed with blood, high hot infantile convulsion, convulsion with spasms for epidemic febrile disease.
Herba Taraxaci: nature and flavor are sweet, micro-hardship, cold, enter spleen, stomach, kidney three warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Can be used for upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.
Herba Violae: bitter in the mouth, pungent, cold in nature, enters the heart, Liver Channel.There is the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, main influenza; Upper respiratory tract infection; Tonsillitis; Infectious hepatitis; Intestinal is scorching; Dysentery; Nephritis; Parotitis; Conjunctivitis; Acute appendicitis; Furuncle carbuncle; Scrofula.Heat-clearing and toxic substances removing.Control furuncle carbuncle, jaundice interior-heat, children's's nose bleeding, appendicitis, venom.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent, return liver, heart channel.Function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.To furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc. have good curative effect.
Rhizoma Smilacis Glabrae: sweet in the mouth, light, property is put down, poisonous; Enter liver, stomach, kidney, spleen channel.Removing toxic substances, dehumidifying, sharp joint.Cure mainly syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treat furuncle, carbuncle, scrofula, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.
Herba Houttuyniae: cold nature, bitter in the mouth, returns lung meridian, bladder, large intestine channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.
Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature; Return lung meridian, spleen channel, large intestine channel, stomach warp.Function heat-clearing and toxic substances removing, rash.Not smooth, maculopapulae due to toxic heat, diseases caused by exogenous pathogenic factor exterior syndrome is thoroughly sent out, weight, women's leukorrhagia, metrorrhagia under epidemic disease fire-toxin, aphtha, pharyngalgia, headache cold and heat, carbuncle sore tumefacting virus, sinking of QI of middle-JIAO, diarrhea due to hypofunction of the spleen, chronic dysentery for measles.
Radix Trichosanthis: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, salty, GUIXIN, Liver Channel.Be mainly used in that heat in blood poison is contained, macule purple black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire etc.
Herba Lophatheri: nature and flavor, sweet, be slightly cold.GUIXIN, stomach, small intestine meridian.Clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, hot urination drenches pain, aphtha of the mouth and tongue.
Cortex Phellodendri: bitter, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Cortex Dictamni: bitter, salty, cold; Enter spleen channel, lung meridian, small intestine meridian, stomach warp, urinary bladder channel.Control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold; Principal solution heat is yellow, wine is yellow, acute jaundice, paddy Huang, labor are yellow.
Radix et Rhizoma Thalictri: bitter in the mouth; Cold in nature; GUIXIN, liver, large intestine channel.Heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly damp-heat dysentery; Jaundice; Sore swollen toxin; Conjunctival congestion and swelling pain; Cold, fever; Cancerous protuberance.
Radix Cirsii Japonici: cool in nature, sweet in the mouth, bitter, nontoxic, GUIXIN, Liver Channel.Cooling blood for hemostasis, removing toxicity for eliminating carbuncles.Control haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, acute appendicitis, carbuncle and ulcer toxic swelling, furuncle.
Herba Cirsii: sweet, bitter, cold, GUIXIN, Liver Channel.Function cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Radix Sanguisorbae: picric acid, cold, nontoxic; Return liver, lung, kidney, large intestine channel.Function cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.For spitting blood, spitting of blood, epistaxis, hematuria, has blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, burn due to hot liquid or fire, snake bite and insect sting.
Radix Boehmeriae: sweet in the mouth is sliding, cold, nontoxic; Enter lung, spleen channel.Function heat clearing away, hemostasis, removing toxic substances, dissipating blood stasis.Control calentura extreme thirst, mad greatly, stranguria with blood, the difficulty in urination, spit blood, hematochezia, leucorrhea with red and white discharge, erysipelas, carbuncle, traumatic injury, snake bite and insect sting.
Calculus Bovis: bitter, cool; GUIXIN, Liver Channel.Clear away heart-fire, eliminating phlegm, has one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.
Margarita: sweet, salty, cold.GUIXIN, Liver Channel.To calm the nerves arresting convulsion, improving eyesight removing nebula, removing toxic substances and promoting granulation.For insomnia of palpitating with fear, infantile convulsion epilepsy, the raw nebula of order, skin infection is not held back.
The pig iron falls: pungent; Cool; GUIXIN; Liver Channel.Checking hyperfunction of the liver for relieving convulsion; Removing toxic substances sore; Enrich blood.Main demented; Febrile delirium; Palpitation and being susceptible to fright; Rheumatic arthralgia; Anemia; Sore swollen toxin.
Borneolum Syntheticum: arduous, cool; Enter the heart, lung meridian.Logical all keys, loose stagnated fire, removing nebula improving eyesight, reducing swelling and alleviating pain.Control apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
Herba Potentillae Freynianae: bitter, is slightly cold.Heat-clearing and toxic substances removing, dissipating blood stasis stops blooding.Control bone tuberculosis, stomatitis, scrofula, traumatic injury, traumatic hemorrhage.
Herba Sedi Multicaulis: cold nature, sweet in the mouth is micro-pungent.Heat-clearing and toxic substances removing, hemostasis, wind-damp dispelling.Control laryngopharynx swelling and pain, epistaxis, wind heat is dizzy, rheumatic arthritis, nasal eczema, eczema, sore.
Achillea millefolium L.: sweetness and bitterness is pungent, cold in nature.Heat-clearing and toxic substances removing, regulating menstruation by adjusting the flow of blood.Control carbuncle furuncle and phyma poison, traumatic injury, bleeding hemorrhoids, menoxenia.
Caulis et Folium Crotalariae Assamicae: light; Cold.Return lung; Spleen channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, inducing diuresis to remove edema.Main children's's head sore, aphtha, toothache, cough due to lung-heat spits blood, traumatic injury, traumatic hemorrhage, edema, renal calculus, cystitis, rheumatic ostalgia.
Caulis Endadae phaseoloidis: bitter; Puckery; Flat.Return kidney channel.Expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome; Traumatic injury; Lumbar muscle strain; Numb limbs and tense tendons.
Radix abelmoschi manihot: sweet, cold, sliding, nontoxic.Return lung; Kidney; Urinary bladder channel.Diuretic, dissipating blood stasis, detumescence, removing toxic substances.Control gonorrhea, edema, galactostasis, parotitis, carbuncle.
Red palpus palpus: bitter in the mouth; Cold nature.Return liver; Heart channel.Promoting blood flow to regulate menstruation; Stasis-dispelling and pain-killing.Main menoxenia; Dysmenorrhea; Amenorrhea; Ectopic pregnancy hepatosplenomegaly; Thoracic obstruction angor; Dysphoria and insomnia; Sore and toxic.
Rhizoma Arisaematis: pungent; Bitter; Flat.Tranquilizing by nourishing the heart; Liver heat removing and eyesight improving.Main severe palpitation; Neurasthenia; Conjunctival congestion and swelling pain; Coronary heart disease; Hypertension etc.
Ziziphora bungeana Juz.: acrid in the mouth; Cool in nature.GUIXIN, kidney channel.Dispelling wind and heat pathogens; Stretch the head clearly; Calm the nerves strong.Main anemopyretic cold; Headache; Pharyngalgia; Insomnia; Dreaminess; Osteomalacia; Sexual impotence.
Radix Rosae Bracteatae: sweet, bitter, puckery; Temperature.Return spleen; Kidney channel.Strengthening the spleen the kidney invigorating, astringing intestine to stop diarrhea of astringing the lung, hidroschesis, promoting blood flow to regulate menstruation, wind-damp dispelling, powder detoxifcation.Main soreness of the waist and knees, edema, beriberi, seminal emission, night sweat, the prolapse of the uterus, chronic diarrhea, proctoptosis, cough and asthma, gastric abscess, hernia, rheumatic arthralgia, menoxenia, amenorrhea, leukorrhagia, scrofula, acute appendicitis, scalds.
The Receptaculum Fici Pumilae: sweet, flat.Tonifying the kidney to consolidate the essence, invigorates blood circulation, lactogenic.For seminal emission, sexual impotence, galactostasis, amenorrhea, chyluria.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition 1
Embodiments provide a kind of Chinese medicine composition for preventing and treating sheep stomatitis, be made up of the raw medicinal material of following parts by weight: Flos Lonicerae 23 weight portion, Fructus Forsythiae 15 weight portion, Herba Andrographis 16 weight portion, Folium Isatidis 27 weight portion, Indigo Naturalis 17 weight portion, Herba Taraxaci 23 weight portion, Herba Violae 31 weight portion, Flos Chrysanthemi Indici 29 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Houttuyniae 18 weight portion, Rhizoma Cimicifugae 32 weight portion, Radix Trichosanthis 35 weight portion, Radix Arnebiae (Radix Lithospermi) 16 weight portion, Herba Lophatheri 30 weight portion, Cortex Phellodendri 23 weight portion, Cortex Dictamni 17 weight portion, Radix et Rhizoma Thalictri 11 weight portion, Radix Cirsii Japonici 24 weight portion, Herba Cirsii 26 weight portion, Radix Sanguisorbae 14 weight portion, Radix Boehmeriae 28 weight portion, Calculus Bovis 23 weight portion, Margarita 31 weight portion, the pig iron falls 17 weight portions, Borneolum Syntheticum 11 weight portion, Herba Potentillae Freynianae 17 weight portion, Herba Sedi Multicaulis 25 weight portion, Achillea millefolium L. 10 weight portion, Caulis et Folium Crotalariae Assamicae 8 weight portion, Caulis Endadae phaseoloidis 3 weight portion and Radix abelmoschi manihot 18 weight portion.
Its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add the water soaking 4 hours relative to the mixture quality 3 times obtained, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 90% soak with ethanol 1.5 hours, extract twice, each 2 hours, merge extractive liquid, filters, concentrated, 160 orders filter, 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
Embodiment 2 Chinese medicine composition 2
Embodiments providing a kind of Chinese medicine composition for preventing and treating sheep stomatitis, being made up of the raw medicinal material of following parts by weight: Flos Lonicerae 23 weight portion, Fructus Forsythiae 15 weight portion, Herba Andrographis 16 weight portion, Folium Isatidis 27 weight portion, Indigo Naturalis 17 weight portion, Herba Taraxaci 23 weight portion, Herba Violae 31 weight portion, Flos Chrysanthemi Indici 29 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Houttuyniae 18 weight portion, Rhizoma Cimicifugae 32 weight portion, Radix Trichosanthis 35 weight portion, Radix Arnebiae (Radix Lithospermi) 16 weight portion, Herba Lophatheri 30 weight portion, Cortex Phellodendri 23 weight portion, Cortex Dictamni 17 weight portion, Radix et Rhizoma Thalictri 11 weight portion, Radix Cirsii Japonici 24 weight portion, Herba Cirsii 26 weight portion, Radix Sanguisorbae 14 weight portion, Radix Boehmeriae 28 weight portion, Calculus Bovis 23 weight portion, Margarita 31 weight portion, the pig iron falls 17 weight portions, Borneolum Syntheticum 11 weight portion, Herba Potentillae Freynianae 17 weight portion, Herba Sedi Multicaulis 25 weight portion, Achillea millefolium L. 10 weight portion, Caulis et Folium Crotalariae Assamicae 8 weight portion, Caulis Endadae phaseoloidis 3 weight portion, Radix abelmoschi manihot 18 weight portion, red palpus palpus 7 weight portions, Rhizoma Arisaematis 9 weight portion, Ziziphora bungeana Juz. 11 weight portion, Radix Rosae Bracteatae 15 weight portion and the Receptaculum Fici Pumilae 4 weight portion.
Its preparation method is as follows:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.07, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes granule, in 40 DEG C of dryings, obtains granule.
The toxicity test of Chinese medicine composition
Extracting honeysuckle 23g, Fructus Forsythiae 15g, Herba Andrographis 16g, Folium Isatidis 27g, Indigo Naturalis 17g, Herba Taraxaci 23g, Herba Violae 31g, Flos Chrysanthemi Indici 29g, Rhizoma Smilacis Glabrae 18g, Herba Houttuyniae 18g, Rhizoma Cimicifugae 32g, Radix Trichosanthis 35g, Radix Arnebiae (Radix Lithospermi) 16g, Herba Lophatheri 30g, Cortex Phellodendri 23g, Cortex Dictamni 17g, Radix et Rhizoma Thalictri 11g, Radix Cirsii Japonici 24g, Herba Cirsii 26g, Radix Sanguisorbae 14g, Radix Boehmeriae 28g, Calculus Bovis 23g, Margarita 31g, the pig iron falls 17g, Borneolum Syntheticum 11g, Herba Potentillae Freynianae 17g, Herba Sedi Multicaulis 25g, Achillea millefolium L. 10g, Caulis et Folium Crotalariae Assamicae 8g, Caulis Endadae phaseoloidis 3g and Radix abelmoschi manihot 18g, red palpus palpus 7g, Rhizoma Arisaematis 9 g, Ziziphora bungeana Juz. 11 g, Radix Rosae Bracteatae 15 g and the Receptaculum Fici Pumilae 4 g, after mix homogeneously, pulverize, in the mixture after pulverizing, add the water of 1200g, decoct 2.5 hours, filter, the water adding 500g in filtering residue decocts 1.5 hours again, filters, and by twice filtrate mixing, is evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
(1) for examination animal
Choose 3, Liuzhou goat plant make a definite diagnosis after sick sheep in random selecting 120 sick sheep as treatment contrast test object; Another from the plant of other anosis goats of Liuzhou random selecting 120 health 1 monthly age lambs as prevention contrast test object.
(2) pathological material of disease extracts
Get the adult goat oral mucous epithelia of 4 natural occurrence 1-2 days.Before taking pathological material of disease, first wipe cleaning with the cotton that sterile saline is dipped and urge disease oral cavity for several times, then hold sharp sword that scalding crosses and take the photograph son epithelium of tearing and move in 50% sterile glycerol saline, save backup.Face the used time, claim its weight, add sterile saline make suspension in 1:20 ratio, every milliliter outstanding shakes in liquid, adds penicillin 2000 unit and streptomycin 1000 unit, for subsequent use 4-10 DEG C of left at room temperature 4 hours.
(3) contrast experiment is prevented:
120 of random choose healthy lambs are divided at random 3 groups (embodiment group 1, embodiment group 2 and matched groups), wherein, embodiment group 1, embodiment group 2 use the spray of the embodiment of the present invention 1, the granule of embodiment 2 respectively, matched group does not use any medicine, after being used in conjunction 4 days, get the pathological material of disease suspension of goat, to sheep mucosa scratch inoculation in sheep lip of embodiment group 1, embodiment group 2 and matched group, observed and recorded respectively organizes the sickness rate of sheep, and result is as shown in table 1.
Table 1 preventive effect synopsis
Data from table 1: Chinese medicine composition of the present invention has obvious preventive effect to sheep stomatitis.
(4) contrast test is treated:
Curative effect determinate standard
Cure: suffer from sheep after the treatment of 1 week, its Oral symptoms disappears, and can normally take food, temperature recovery is normal.
Effective: the Oral symptoms of suffering from sheep disappears substantially, food-intake compares increase with before treatment, and temperature recovery is normal.
Invalid: suffer from sheep after the treatment of 1 week, its Oral symptoms still exists, and body temperature is higher, and food-intake is without increase.
Be divided at random by 120 of random selecting sick sheep 3 groups (treatment by Chinese herbs group, western medicine group, blank groups), treat with different medicine, wherein, treatment by Chinese herbs group selects the Chinese medicine composition 2 of embodiment 2, and dose is 0.6g/kg every day, takes 4 days continuously; 25 tablets of metronidazoles of every sheet net weight 0.2g are ground into powder by western medicine group, be mixed in 30ml warm water and stir, finally add 70ml glycerol and be hybridly prepared into the metronidazole glycerine mixture that concentration is 0.5%, after first rinsing disease sheep oral cavity with concentration 0.2% potassium permanganate, metronidazole glycerine mixture is embrocated at its affected part, every day each 1 time sooner or later, continuous use 7 days; Blank group does not feed any medicine.Observed and recorded respectively organizes cure rate and the healing time of sheep, and result is as shown in table 2.
Table 2 therapeutic effect synopsis
Data from table 2: Chinese medicine composition of the present invention is obviously better than western medicine group to sheep stomatitis therapeutic effect, improve cure rate.
Model case:
Choose the sick sheep 70 that veterinary station is accepted for medical treatment, be diagnosed as sheep stomatitis.Disease shows as poor appetite, sialorrhea in mouth, and chew slowly, body temperature is elevated to about 40 DEG C, and mucosa swelling appears in the sick sheep cavity interior of part, and with exedens focus.
Choose 32 ill sheep wherein, starting to feed is added with the feedstuff of the embodiment of the present invention 2 granule, and granule is mixed in conventional feed according to 4:100 weight ratio, feeds 3 days, and by above treatment, namely sick sheep fully recovers for 3 days.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. one kind for preventing and treating the Chinese medicine composition of sheep stomatitis; it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Indigo Naturalis, Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Smilacis Glabrae, Herba Houttuyniae, Rhizoma Cimicifugae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Herba Lophatheri, Cortex Phellodendri, Cortex Dictamni, Radix et Rhizoma Thalictri, Radix Cirsii Japonici, Herba Cirsii, Radix Sanguisorbae, Radix Boehmeriae, Calculus Bovis, Margarita, the pig iron fall, Borneolum Syntheticum, Herba Potentillae Freynianae, Herba Sedi Multicaulis, Achillea millefolium L., Caulis et Folium Crotalariae Assamicae, Caulis Endadae phaseoloidis and Radix abelmoschi manihot.
2. the Chinese medicine composition for preventing and treating sheep stomatitis according to claim 1, is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 21-36 weight portion, Fructus Forsythiae 10-25 weight portion, Herba Andrographis 13-26 weight portion, Folium Isatidis 23-35 weight portion, Indigo Naturalis 14-24 weight portion, Herba Taraxaci 17-34 weight portion, Herba Violae 20-34 weight portion, Flos Chrysanthemi Indici 21-32 weight portion, Rhizoma Smilacis Glabrae 16-28 weight portion, Herba Houttuyniae 13-27 weight portion, Rhizoma Cimicifugae 23-35 weight portion, Radix Trichosanthis 25-39 weight portion, Radix Arnebiae (Radix Lithospermi) 14-30 weight portion, Herba Lophatheri 20-33 weight portion, Cortex Phellodendri 13-27 weight portion, Cortex Dictamni 17-29 weight portion, Radix et Rhizoma Thalictri 8-19 weight portion, Radix Cirsii Japonici 21-37 weight portion, Herba Cirsii 16-30 weight portion, Radix Sanguisorbae 12-26 weight portion, Radix Boehmeriae 14-33 weight portion, Calculus Bovis 21-36 weight portion, Margarita 24-38 weight portion, the pig iron falls 17-37 weight portion, Borneolum Syntheticum 5-13 weight portion, Herba Potentillae Freynianae 17-31 weight portion, Herba Sedi Multicaulis 13-28 weight portion, Achillea millefolium L. 10-25 weight portion, Caulis et Folium Crotalariae Assamicae 4-10 weight portion, Caulis Endadae phaseoloidis 3-8 weight portion and Radix abelmoschi manihot 16-27 weight portion.
3. the Chinese medicine composition for preventing and treating sheep stomatitis according to claim 1 and 2, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 23 weight portion, Fructus Forsythiae 15 weight portion, Herba Andrographis 16 weight portion, Folium Isatidis 27 weight portion, Indigo Naturalis 17 weight portion, Herba Taraxaci 23 weight portion, Herba Violae 31 weight portion, Flos Chrysanthemi Indici 29 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Houttuyniae 18 weight portion, Rhizoma Cimicifugae 32 weight portion, Radix Trichosanthis 35 weight portion, Radix Arnebiae (Radix Lithospermi) 16 weight portion, Herba Lophatheri 30 weight portion, Cortex Phellodendri 23 weight portion, Cortex Dictamni 17 weight portion, Radix et Rhizoma Thalictri 11 weight portion, Radix Cirsii Japonici 24 weight portion, Herba Cirsii 26 weight portion, Radix Sanguisorbae 14 weight portion, Radix Boehmeriae 28 weight portion, Calculus Bovis 23 weight portion, Margarita 31 weight portion, the pig iron falls 17 weight portions, Borneolum Syntheticum 11 weight portion, Herba Potentillae Freynianae 17 weight portion, Herba Sedi Multicaulis 25 weight portion, Achillea millefolium L. 10 weight portion, Caulis et Folium Crotalariae Assamicae 8 weight portion, Caulis Endadae phaseoloidis 3 weight portion and Radix abelmoschi manihot 18 weight portion.
4. the Chinese medicine composition for preventing and treating sheep stomatitis according to any one of claim 1-3, is characterized in that, described Chinese medicine composition also comprises red palpus palpus, Rhizoma Arisaematis, Ziziphora bungeana Juz., Radix Rosae Bracteatae and the Receptaculum Fici Pumilae.
5. the Chinese medicine composition for preventing and treating sheep stomatitis according to any one of claim 1-4, is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 21-36 weight portion, Fructus Forsythiae 10-25 weight portion, Herba Andrographis 13-26 weight portion, Folium Isatidis 23-35 weight portion, Indigo Naturalis 14-24 weight portion, Herba Taraxaci 17-34 weight portion, Herba Violae 20-34 weight portion, Flos Chrysanthemi Indici 21-32 weight portion, Rhizoma Smilacis Glabrae 16-28 weight portion, Herba Houttuyniae 13-27 weight portion, Rhizoma Cimicifugae 23-35 weight portion, Radix Trichosanthis 25-39 weight portion, Radix Arnebiae (Radix Lithospermi) 14-30 weight portion, Herba Lophatheri 20-33 weight portion, Cortex Phellodendri 13-27 weight portion, Cortex Dictamni 17-29 weight portion, Radix et Rhizoma Thalictri 8-19 weight portion, Radix Cirsii Japonici 21-37 weight portion, Herba Cirsii 16-30 weight portion, Radix Sanguisorbae 12-26 weight portion, Radix Boehmeriae 14-33 weight portion, Calculus Bovis 21-36 weight portion, Margarita 24-38 weight portion, the pig iron falls 17-37 weight portion, Borneolum Syntheticum 5-13 weight portion, Herba Potentillae Freynianae 17-31 weight portion, Herba Sedi Multicaulis 13-28 weight portion, Achillea millefolium L. 10-25 weight portion, Caulis et Folium Crotalariae Assamicae 4-10 weight portion, Caulis Endadae phaseoloidis 3-8 weight portion, Radix abelmoschi manihot 16-27 weight portion, red palpus palpus 6-12 weight portion, Rhizoma Arisaematis 8-14 weight portion, Ziziphora bungeana Juz. 9-16 weight portion, Radix Rosae Bracteatae 11-17 weight portion and Receptaculum Fici Pumilae 3-7 weight portion.
6. the Chinese medicine composition for preventing and treating sheep stomatitis according to any one of claim 1-5, is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Flos Lonicerae 23 weight portion, Fructus Forsythiae 15 weight portion, Herba Andrographis 16 weight portion, Folium Isatidis 27 weight portion, Indigo Naturalis 17 weight portion, Herba Taraxaci 23 weight portion, Herba Violae 31 weight portion, Flos Chrysanthemi Indici 29 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Houttuyniae 18 weight portion, Rhizoma Cimicifugae 32 weight portion, Radix Trichosanthis 35 weight portion, Radix Arnebiae (Radix Lithospermi) 16 weight portion, Herba Lophatheri 30 weight portion, Cortex Phellodendri 23 weight portion, Cortex Dictamni 17 weight portion, Radix et Rhizoma Thalictri 11 weight portion, Radix Cirsii Japonici 24 weight portion, Herba Cirsii 26 weight portion, Radix Sanguisorbae 14 weight portion, Radix Boehmeriae 28 weight portion, Calculus Bovis 23 weight portion, Margarita 31 weight portion, the pig iron falls 17 weight portions, Borneolum Syntheticum 11 weight portion, Herba Potentillae Freynianae 17 weight portion, Herba Sedi Multicaulis 25 weight portion, Achillea millefolium L. 10 weight portion, Caulis et Folium Crotalariae Assamicae 8 weight portion, Caulis Endadae phaseoloidis 3 weight portion, Radix abelmoschi manihot 18 weight portion, red palpus palpus 7 weight portions, Rhizoma Arisaematis 9 weight portion, Ziziphora bungeana Juz. 11 weight portion, Radix Rosae Bracteatae 15 weight portion and the Receptaculum Fici Pumilae 4 weight portion.
7., according to the arbitrary described Chinese medicine composition for preventing and treating sheep stomatitis of claim 1-6, it is characterized in that, the dosage form of described Chinese medicine composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
8., according to the arbitrary described Chinese medicine composition for preventing and treating sheep stomatitis of claim 1-6, it is characterized in that, the dosage form of described Chinese medicine composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
9. a preparation method for the Chinese medicine composition for preventing and treating sheep stomatitis as described in any one of claim 1-6, is characterized in that, the dosage form of described Chinese medicine composition is spray, and its preparation method comprises the following steps:
A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;
B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, filters, concentrated, 80-160 order filters, 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;
C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.
10. a preparation method for the Chinese medicine composition in control sheep stomatitis as described in any one of claim 1-6, it is characterized in that, the dosage form of described Chinese medicine composition is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
CN201410504272.5A 2014-09-28 2014-09-28 Traditional Chinese medicine composition for preventing and treating sheep stomatitis and preparation method thereof Pending CN104306757A (en)

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魏国明: ""口疮散"配合牛黄解毒片治疗羊口炎", 《中兽医医药杂志》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873756A (en) * 2015-06-11 2015-09-02 山东新希望六和集团有限公司 Pharmaceutical composition for preventing and curing pig vesicular stomatitis and preparation method thereof
CN105030813A (en) * 2015-07-07 2015-11-11 安徽科技学院 Compound preparation used for treating sheep stomatitis
CN105030813B (en) * 2015-07-07 2018-05-01 安徽科技学院 A kind of compound preparation for being used to treat sheep mouth inflammation
CN106235322A (en) * 2016-04-17 2016-12-21 马鞍山市志诚科技有限公司 A kind of prevent and treat the dry and cracked nutrient formulation nano-particle of tongue body and preparation processing method
CN105920099A (en) * 2016-06-14 2016-09-07 王海波 Feed additive composition for improving Boer goat immunity

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