CN104606638A

CN104606638A - Medicine for treating damp-heat type acute eczema and preparation method thereof

Info

Publication number: CN104606638A
Application number: CN201510049037.8A
Authority: CN
Inventors: 董梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-01-30
Filing date: 2015-01-30
Publication date: 2015-05-13

Abstract

The invention discloses a medicine for treating damp-heat type acute eczema and a preparation method thereof. The medicine comprises the following raw medicinal materials: Chinese violet, gynura bicolor, uncaria, watermelon peel, common andrographis Herb, rhizoma smilacis glabrae, dandelion, pyrrosia lingua, hairy euphorbia, Saxifraga stolonifera, elsholtzia, anderson ironweed stem and root, Chinese tamarisk twig, burdock, winter rape, Platycodon grandiflorum, stir-baked squama manitis, China rose, coleseed, curcuma zedoary, radices trichosanthis, rhizoma anemarrhenae, ramie root, mulberry fruit, the shoot of mao bamboo, adhesive rehmannia dried root, Scutellaria baicalensis, roasted Rhizoma Atractylodis Macrocephalae, peach leaf, folium eucalypti and Licorice Roots Northwest Origin. The medicine disclosed by the invention has the beneficial effects that the medicine has the effects of clearing heat and removing toxicity, also achieves the effects of inducing diuresis and clearing damp, purging fu-organs to eliminate heat, opening muscular striae, promoting blood circulation to remove blood stasis, resolving hard lump, enriching yin and nourishing blood and is used for treating the damp-heat type acute eczema. Moreover, the medicine refers to a purely natural medicine, and is green, pollution-free, safe, effective, low in toxic and side effects and fewer in adverse reactions; the administration is convenient, and the medicine is easily accepted by the patient; the formula is simple, and the preparation process is simple and convenient; and the cure time is short, and the disease is difficult to reoccur after being healed.

Description

A kind ofly treat medicine of damp-heat acute eczema and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, particularly a kind ofly treat medicine of damp-heat acute eczema and preparation method thereof.

Background technology

Acute eczema is that one has pleomorphism erythra and oozes out tendency, accompanies violent pruritus, the scytitis of easy recurrent exerbation.A kind of delayed of acute eczema pathogeny mainly caused by inside and outside motivating factor interaction can allergy.Can occur in any position of whole body, but often more easily see head, extremity bend the positions such as side, pudendum, brothers' back of the body.Often be symmetric, be generally and be confined to some position, and whole body universal eczema be very rare.

Etiology and pathology

1. endogenous cause of ill

The allergic constitution of patient is the important pathogenic factors of primary disease, relevant with heredity, can with age, environment and changing.Neural factors, as worried, nervous, excited, insomnia, fatigue etc., also can bring out or aggravate disease.In addition, the factor such as endocrine, metabolism, gastrointestinal dysfunction, infection focus also has relation with morbidity.

2. exopathogenic factor

Daylight, damp and hot, dry, scratch, rub, the factor such as cosmetics, soap, fur, fuel, staple fibre all can bring out eczema.Some food such as food such as fish and shrimp, egg can make eczema increase the weight of.

Clinical manifestation

Morbidity is anxious, is often symmetric, sends out well with women's head-ornaments, extremity and external genital.Often often scratch because of violent pruritus, aggravate disease.

Show as constitutional and pleomorphism erythra.Erythema of being everlasting basis there is syringe needle arrive pimple, the papulovesicle of foxtail millet grain size, have phlysis time serious, permelting answer print, indefinite border Chu.

In the periphery of infringement, above-mentioned pleomorphism erythra is sparse gradually.Pruritus is heavier, and Chang Yin scratches and makes erythra form rotten to the corn face, and has serosity to ooze out and form a scab.

In disease, the various erythra such as erythema, pimple, vesicle, pustule, erosion, incrustation can occur in proper order, but often have 2-3 kind erythra simultaneously and deposit or at certain one-phase based on certain type erythra.

As formed pustule, pus and pus crusts with secondary infection, corresponding lymph node can enlargement.Can with General Symptomies such as heatings when infecting serious.

Subjective symptoms has violent pruritus and burning sensation, can paroxysm increase the weight of, especially with aggravation in night, and impact sleep and work.

Western medical treatment

Constitutional treatment:

Antihistamine drug: common medicine has chlorphenamine (chlorphenamine); Cyproheptadine; Diphenhydramine; Also the medicine without the calm side effect of maincenter can be selected, as terfenadine; Cetirizine.Can two kinds of medicine alternate application or use in conjunction,

Nonspecific desensitization is treated: available 10% calcium gluconate 10ml or 10% sodium thiosulfate 10ml intravenous injection; Or 0.25% procaine vitaminize intravenous injection.

Glucocorticoid: generally do not advocate application, remarkable and general originator can consider that short-term is taken, as prednisone to acute phase inflammatory.

Antibiotic: to bacteriological infection, heating, lymphadenectasis person, can select as erythromycin for oral administration, ciprofloxacin or intramuscular injection penicillin etc.

Topical therapeutic:

1. flushing, pimple or minority phlycten is only had and without sepage at the disease initial stage, control and should relax antiinflammatory, avoid stimulating, soak can be selected or there is the lotion of itching-relieving action, conventional 2% ~ 3% boric acid water soak, Calamine Lotion or 2% Camphor tree alcohol (Borneolum Syntheticum) 5% Alumen Calamine Lotion etc.

2. obvious person is oozed out in vesicle erosion, should restrain, antiinflammatory, to promote that epidermis recovers, anticorrosion convergence medicinal liquid can be selected to make soak or evaporation net for catching birds or fish bag, dust head as Compound Zinc copper solution, 2% ~ 3% boric acid water, 0.5% lead acetate or Burow's Solution.There is secondary infection person can with 0.1% ethacridine (ethacridine) solution, to erosion ooze out comparatively the lighter or incrustation phase except with except soak, also can use zinc oxid oil, the loose or Triple Magic Powder vegetable oil of 10% bismuth subgallate zinc ointment, damp eliminating or Licorice oil mix well external in right amount.

3. acute eczema latter stage---the exfoliation phase, as dealt with improperly, the course of disease is easily made to delay recurrence or transfer to chronic.Current period Therapeutic Principle should protect skin lesion, avoids environmental stimuli, promotes that cutin is newborn, eliminates remaining inflammation, can apply refrigerant ointment, Rhizoma Coptidis ointment or general Emulsion.

The maximum side effect of antihistaminic medicine be drowsiness, have sedation to brain.Glucocorticoid widely applies the untoward reaction caused for a long time: substance metabolism widely applies glucocorticoid can cause substance metabolism for a long time with water and salt metabolic disturbance and water and salt metabolic disturbance, there is hemo-hyperadrenocorticism syndrome, as symptoms such as edema, hypokalemia, hypertension, glycosuria, thinning of skin, moon face, buffalo hump, central obesity, hirsutism, acne, myasthenia and amyotrophy, the wound healing of wounded patient can be delayed.Often can bring out and infect or increase the weight of to infect, focus of infection diffusion potential in body or static focus of infection resume combustion can be made, particularly original resistance descender, as nephrotic syndrome, pulmonary tuberculosis, aplastic amenia people etc., reduce the resistance of gastric mucosa, therefore can bring out or aggravate peptic ulcer, glucocorticoid also can cover the initial symptoms of ulcer, so that occur that burst is hemorrhage and wait severe complication with perforation, pancreatitis or fatty liver can be brought out to small number of patients.Hypertension and atherosclerosis can be brought out.Osteoporosis and vertebral compression fracture osteoporosis and vertebral compression fracture be that various age patient applies complication serious in glucocorticoid treatment.Neuropsychiatric abnormalities glucocorticoid can cause the dystropy of various ways.Often can cover the symptom of some disease as glad phenomenon and affect diagnosis adversely.And for example nervousness, excitement, insomnia, Feeling changes or even occur obvious psychotic symptoms.Some patient also has suicidal tendency.In addition, glucocorticoid also may bring out epilepsy.Cataract and glaucoma glucocorticoid can bring out cataract, and whole body or topical all can occur.

Doctor trained in Western medicine curative effect is undesirable, and relapse rate is high, and toxic and side effects is comparatively large, expensive, and extensive patients is not easy to accept.

But Chinese medicine acute eczema, can make up the deficiency of doctor trained in Western medicine, carries out Comprehensive Treatment, adopt Chinese crude drug, medicine source is extensive, and price is low, not easily produces drug resistance, safe and effective, regulate QI and blood, timely symptom management, improve cure rate, improve the immunity of animal economy.

Acute eczema is divided into three types by the traditional Chinese medical science:

Anemopyretic: be more common in disease early stage, morbidity rapidly, erythra based on erythema, pimple, pruritus, red tongue, yellow and thin fur, floating and rapid pulse.

Blood-heat type: erythra is based on erythema, pimple, and violent pruritus, accompanies blood crusts, scratch, red tongue, white and thin fur or BOHUANG, stringy and rolling pulse.

Damp-heat type: skin lesion is except erythema, pimple, and also have papulovesicle, vesicle and erosion, sepage or incrustation, pruritus is heavier, accompanies vexed, thirsty, yellowish urine, large dry stool, red tongue, yellow and greasy fur, slippery and rapid pulse.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of and treats medicine of damp-heat acute eczema and preparation method thereof, and the present invention instructs, adopt pure natural medical, green non-pollution, safely, effectively, toxic and side effects is low, and untoward reaction is less; Convenient drug administration, is easy to accept; Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs heat-clearing and toxic substances removing is carried out on the basis of Overall View, and not only can heal local skin lesion, simultaneously scalable body's immunity, and enhancing body defence pathogenic factor ability, promotes to get well.

For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of damp-heat acute eczema, wherein, comprise following raw medicinal material: Herba Violae, Radix Semiaquilegiae, Ramulus Uncariae Cum Uncis, Citrullus vulgaris Cui clothing, Herba Andrographis, Rhizoma Smilacis Glabrae, Herba Taraxaci, Folium Pyrrosiae, Ramulus et Folium Bauhiniae Faberi, Herba Saxifragae, Herba Moslae, Caulis Vernoniae Andersonii, Cacumen Tamaricis, Fructus Arctii, Semen Brassicae Campestris, Radix Platycodonis, stir-baked SQUAMA MANITIS, Flos Rosae Chinensis, coleseed, Rhizoma Curcumae, Radix Trichosanthis, the Rhizoma Anemarrhenae, Radix Boehmeriae, Fructus Mori, Caulis Bambusae Germinatus, Radix Rehmanniae, Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched), Folium Persicae, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Radix Glycyrrhizae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 7-15 weight portion, Radix Semiaquilegiae 6-13 weight portion, Ramulus Uncariae Cum Uncis 9-17 weight portion, Citrullus vulgaris Cui clothing 17-26 weight portion, Herba Andrographis 11-21 weight portion, Rhizoma Smilacis Glabrae 15-25 weight portion, Herba Taraxaci 10-17 weight portion, Folium Pyrrosiae 12-18 weight portion, Ramulus et Folium Bauhiniae Faberi 12-27 weight portion, Herba Saxifragae 16-28 weight portion, Herba Moslae 21-30 weight portion, Caulis Vernoniae Andersonii 4-10 weight portion, Cacumen Tamaricis 15-25 weight portion, Fructus Arctii 13-23 weight portion, Semen Brassicae Campestris 9-17 weight portion, Radix Platycodonis 12-29 weight portion, stir-baked SQUAMA MANITIS 8-16 weight portion, Flos Rosae Chinensis 17-29 weight portion, coleseed 16-24 weight portion, Rhizoma Curcumae 12-28 weight portion, Radix Trichosanthis 14-25 weight portion, Rhizoma Anemarrhenae 13-27 weight portion, Radix Boehmeriae 21-29 weight portion, Fructus Mori 15-28 weight portion, Caulis Bambusae Germinatus 10-18 weight portion, Radix Rehmanniae 23-38 weight portion, Radix Scutellariae 23-35 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 30-42 weight portion, Folium Persicae 22-30 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 23-29 weight portion and Radix Glycyrrhizae 6-13 weight portion.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 9-13 weight portion, Radix Semiaquilegiae 7-11 weight portion, Ramulus Uncariae Cum Uncis 10-15 weight portion, Citrullus vulgaris Cui clothing 19-24 weight portion, Herba Andrographis 13-19 weight portion, Rhizoma Smilacis Glabrae 18-22 weight portion, Herba Taraxaci 11-16 weight portion, Folium Pyrrosiae 13-17 weight portion, Ramulus et Folium Bauhiniae Faberi 15-24 weight portion, Herba Saxifragae 19-25 weight portion, Herba Moslae 23-28 weight portion, Caulis Vernoniae Andersonii 5-9 weight portion, Cacumen Tamaricis 18-23 weight portion, Fructus Arctii 15-21 weight portion, Semen Brassicae Campestris 11-15 weight portion, Radix Platycodonis 16-24 weight portion, stir-baked SQUAMA MANITIS 9-13 weight portion, Flos Rosae Chinensis 19-24 weight portion, coleseed 18-22 weight portion, Rhizoma Curcumae 15-25 weight portion, Radix Trichosanthis 15-20 weight portion, Rhizoma Anemarrhenae 16-25 weight portion, Radix Boehmeriae 23-27 weight portion, Fructus Mori 17-24 weight portion, Caulis Bambusae Germinatus 12-16 weight portion, Radix Rehmanniae 26-35 weight portion, Radix Scutellariae 25-31 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 32-40 weight portion, Folium Persicae 24-28 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24-27 weight portion and Radix Glycyrrhizae 7-12 weight portion.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 9 weight portion, Radix Semiaquilegiae 11 weight portion, Ramulus Uncariae Cum Uncis 13 weight portion, Citrullus vulgaris Cui clothing 24 weight portion, Herba Andrographis 19 weight portion, Rhizoma Smilacis Glabrae 20 weight portion, Herba Taraxaci 14 weight portion, Folium Pyrrosiae 13 weight portion, Ramulus et Folium Bauhiniae Faberi 24 weight portion, Herba Saxifragae 25 weight portion, Herba Moslae 26 weight portion, Caulis Vernoniae Andersonii 5 weight portion, Cacumen Tamaricis 23 weight portion, Fructus Arctii 19 weight portion, Semen Brassicae Campestris 13 weight portion, Radix Platycodonis 20 weight portion, stir-baked SQUAMA MANITIS 11 weight portion, Flos Rosae Chinensis 24 weight portion, coleseed 19 weight portion, Rhizoma Curcumae 15 weight portion, Radix Trichosanthis 19 weight portion, the Rhizoma Anemarrhenae 25 weight portion, Radix Boehmeriae 26 weight portion, Fructus Mori 21 weight portion, Caulis Bambusae Germinatus 12 weight portion, Radix Rehmanniae 32 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 40 weight portion, Folium Persicae 26 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 27 weight portion and Radix Glycyrrhizae 12 weight portion.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 13 weight portion, Radix Semiaquilegiae 7 weight portion, Ramulus Uncariae Cum Uncis 10 weight portion, Citrullus vulgaris Cui clothing 19 weight portion, Herba Andrographis 17 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Taraxaci 11 weight portion, Folium Pyrrosiae 15 weight portion, Ramulus et Folium Bauhiniae Faberi 21 weight portion, Herba Saxifragae 19 weight portion, Herba Moslae 28 weight portion, Caulis Vernoniae Andersonii 7 weight portion, Cacumen Tamaricis 18 weight portion, Fructus Arctii 21 weight portion, Semen Brassicae Campestris 15 weight portion, Radix Platycodonis 16 weight portion, stir-baked SQUAMA MANITIS 13 weight portion, Flos Rosae Chinensis 22 weight portion, coleseed 22 weight portion, Rhizoma Curcumae 17 weight portion, Radix Trichosanthis 20 weight portion, the Rhizoma Anemarrhenae 16 weight portion, Radix Boehmeriae 27 weight portion, Fructus Mori 24 weight portion, Caulis Bambusae Germinatus 16 weight portion, Radix Rehmanniae 35 weight portion, Radix Scutellariae 31 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 38 weight portion, Folium Persicae 24 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24 weight portion and Radix Glycyrrhizae 7 weight portion.

In described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 11 weight portion, Radix Semiaquilegiae 9 weight portion, Ramulus Uncariae Cum Uncis 15 weight portion, Citrullus vulgaris Cui clothing 22 weight portion, Herba Andrographis 13 weight portion, Rhizoma Smilacis Glabrae 22 weight portion, Herba Taraxaci 16 weight portion, Folium Pyrrosiae 17 weight portion, Ramulus et Folium Bauhiniae Faberi 15 weight portion, Herba Saxifragae 22 weight portion, Herba Moslae 23 weight portion, Caulis Vernoniae Andersonii 9 weight portion, Cacumen Tamaricis 21 weight portion, Fructus Arctii 15 weight portion, Semen Brassicae Campestris 11 weight portion, Radix Platycodonis 24 weight portion, stir-baked SQUAMA MANITIS 9 weight portion, Flos Rosae Chinensis 19 weight portion, coleseed 18 weight portion, Rhizoma Curcumae 25 weight portion, Radix Trichosanthis 15 weight portion, the Rhizoma Anemarrhenae 23 weight portion, Radix Boehmeriae 23 weight portion, Fructus Mori 17 weight portion, Caulis Bambusae Germinatus 14 weight portion, Radix Rehmanniae 26 weight portion, Radix Scutellariae 30 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 32 weight portion, Folium Persicae 28 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25 weight portion and Radix Glycyrrhizae 11 weight portion.

When the dosage form of described medicine is ointment, its preparation method comprises the following steps:

Described raw medicinal material is soaked 1-2 hour in described ratio mixing, is then placed in multi-function extractor, first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

When the dosage form of described medicine is spray, its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add relative to the mixture quality 3-5 obtained water soaking 3-10 hour doubly, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, decoct 3 times, merge decoction liquor to filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 60-90% soak with ethanol 0.5-1.5 hour, extract twice, each 1-2 hour, merge extractive liquid, 80-160 order filters, get 6000-10000 rev/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

When the dosage form of described medicine is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds coarse powder 8-10 times amount soak by water 1-3 hour, and second time adds coarse powder 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in the glycerol accounting for a and b mixture gross mass 10% after being mixed with fine powder b by fine powder a and make liniment.

When the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention, has effect of heat-clearing and toxic substances removing, holds concurrently with diuretic damp eliminating, eliminating heat pathogen by purging the bowels, reaches the flesh natural fibre line of meat, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, nourishing YIN nourish blood, treatment damp-heat acute eczema; The present invention instructs, and adopts pure natural medical, green non-pollution, and safely, effectively, toxic and side effects is low, and untoward reaction is less; Convenient drug administration, patient is easy to accept; Formula is simple, processing technology is easy; Healing time is short, not easily recurs after healing.

Detailed description of the invention

The invention provides a kind of medicine for the treatment of damp-heat acute eczema, wherein, comprise following raw medicinal material: Herba Violae, Radix Semiaquilegiae, Ramulus Uncariae Cum Uncis, Citrullus vulgaris Cui clothing, Herba Andrographis, Rhizoma Smilacis Glabrae, Herba Taraxaci, Folium Pyrrosiae, Ramulus et Folium Bauhiniae Faberi, Herba Saxifragae, Herba Moslae, Caulis Vernoniae Andersonii, Cacumen Tamaricis, Fructus Arctii, Semen Brassicae Campestris, Radix Platycodonis, stir-baked SQUAMA MANITIS, Flos Rosae Chinensis, coleseed, Rhizoma Curcumae, Radix Trichosanthis, the Rhizoma Anemarrhenae, Radix Boehmeriae, Fructus Mori, Caulis Bambusae Germinatus, Radix Rehmanniae, Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched), Folium Persicae, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Radix Glycyrrhizae.

Wherein, Herba Violae, Radix Semiaquilegiae, Ramulus Uncariae Cum Uncis, Citrullus vulgaris Cui clothing, Herba Andrographis, Rhizoma Smilacis Glabrae, Herba Taraxaci, Folium Pyrrosiae, Ramulus et Folium Bauhiniae Faberi, Herba Saxifragae heat-clearing and toxic substances removing, wind and heat dispersing, many medicines close and attack sore; Citrullus vulgaris Cui clothing, Rhizoma Smilacis Glabrae, Herba Taraxaci, Ramulus et Folium Bauhiniae Faberi promoting diuresis to remove toxic substance, make damp and hot under let out; Herba Moslae, Caulis Vernoniae Andersonii, Cacumen Tamaricis inducing diaphoresis to dispel wind, prevent the cool of all medicines from holding back, and a surname reaches the flesh natural fibre line of meat; Fructus Arctii, Semen Brassicae Campestris lead to intestinal removing toxic substances; Radix Platycodonis draws the up through head of all medicines; Stir-baked SQUAMA MANITIS, Flos Rosae Chinensis, coleseed, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling; Radix Trichosanthis, the Rhizoma Anemarrhenae, Radix Boehmeriae clearing away heat-fire, dissipation accumulation of heat; Fructus Mori, Caulis Bambusae Germinatus, Radix Rehmanniae tonifying YIN nourish blood; Radix Scutellariae heat clearing and damp drying; The spleen invigorating of Rhizoma Atractylodis Macrocephalae (parched) stomach reinforcing, subsidizes source of generating QI and blood; Folium Persicae, Folium eucalypti globueli (Eucalyptus globulus Labill.) detoxifying and relieving itching; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Violae: bitter in the mouth, pungent, cold in nature, enters the heart, Liver Channel, has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, main influenza; Upper respiratory tract infection; Tonsillitis; Infectious hepatitis; Intestinal is scorching; Dysentery; Nephritis; Parotitis; Conjunctivitis; Acute appendicitis; Furuncle carbuncle; Scrofula.Heat-clearing and toxic substances removing.Control furuncle carbuncle, jaundice interior-heat, children's's nose bleeding, appendicitis, venom.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": removing blood stasis, carbuncle mange is separated, nine kinds of hemorrhoid, all sore diseases.2. " detailed outline ": cure mainly all carbuncle carbuncle on the back, furuncle swells scrofula, innominate toxic swelling, malignant boil.3. " book on Chinese herbal medicine asks former ": removing heat from blood, detumescence poison.Control heat in blood flaccidity due to malnutrition of tendons, deposited skin ulcer is wonderful.4. " south of the Five Ridges gather medicinal herbs record ": make cathartic and tell medicine.5. " Chinese herbal medicine is commonly used in Shanghai ": heat-clearing and toxic substances removing, externally applied toxicity removing detumescence.Control conjunctival congestion and swelling pain, hordeolum, treat pyogenic infections from tumour or sore, acute mastitis, enteritis, diarrhea, venom.6. revive doctor's " Chinese herbal medicine handbook ": control all pyogenic infections, venom, lymphoid tuberculosis, jaundice, nephritis, cystitis, arthralgia, have blood in stool, epistaxis, eye conjunctivitis, prostatitis.

Radix Semiaquilegiae: be the herb of feverfew purple back of the body Herba Senecionis Scandentis .pungent micro-acid is wet, flat.Blood stasis dispelling, invigorates blood circulation, regulating menstruation.Control menoxenia, leukorrhagia, rheumatism, wound in traumatic injury.

Ramulus Uncariae Cum Uncis: sweet, bitter, be slightly cold; Enter Liver Channel, heart channel.Function heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind.Cure mainly infantile convulsion, night cry, intenseness of heat wind symptom, eclamposia, dizziness due to hyperactivity of liver-YANG, liver-fire distending pain in the head." detailed outline ": " the large number of people revolves dizzy, suppressing liver-wind, and except heat in the heart, children's's infantile tic is suffered from abdominal pain, and sends out macule." Tang Materia Medica: " Ramulus Uncariae Cum Uncis goes out Liang Zhou.Leaf is elongated, spinosity between stem, if shape fishhook person." function heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind.Cure mainly infantile convulsion, night cry, intenseness of heat wind symptom, eclamposia, dizziness due to hyperactivity of liver-YANG, liver-fire distending pain in the head.

Citrullus vulgaris Cui clothing: nature and flavor: 1. " detailed outline ": sweet, cool, nontoxic.2. " decoction pieces is newly joined ": light flat micro-hardship.Gui Jing: " Traditional Chinese Medicine in Sichuan will ": enter spleen, stomach two warp.Clearing away summer-heat is antipyretic, quenches the thirst, diuresis.Control summer-heat excessive thirst, oliguria, edema, aphtha of the mouth and tongue.1. " danxi's experiential therapy ": control aphtha notably, Exocarpium Citrulli ashing applies it.2. " key medicine divides agent ": heat between skin can be separated.3. " book on Chinese herbal medicine is new again ": energy heat-transformation relieving restlessness, wind dampness removing is removed.4. " diet spectrum is occupied with breath ": coolly frightened wash summer-heat.5. " decoction pieces is newly joined ": clear summer-heat thoroughly, nourishing the stomach Tianjin.6. " modern Practical Chinese medicinal ": be diuretic.Control nephritis edema, diabetes, jaundice.And can alcoholic intoxication.

Herba Andrographis: bitter in the mouth, cold in nature, return lung stomach urinary bladder channel.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.

Rhizoma Smilacis Glabrae: sweet, light is flat.Return liver, stomach warp.Dehumidifying, removing toxic substances, easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.

Herba Taraxaci: nature and flavor are sweet, micro-hardship, cold.Enter spleen, stomach, kidney three warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation." Bencao Jingshu ": " Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast poison, and should give birth to warm good." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " apply all pyogenic infections from tumour or sore, the ruined tinea skin ulcer of scabies; Dispel the wind, disappear all sores, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.

Folium Pyrrosiae: cold nature, sweet in the mouth, hardship.Return lung, urinary bladder channel function relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.Shennong's Herbal: " Folium Pyrrosiae, bitter in the mouth is put down, main consumptive fever pathogen, and five difficulty in urinations are obstructed, and diuresis water leads to, a stone fasten hide or leather on (sound sugarcane), on the stone of raw mountain valley." " Bencao Congxin ": " and calculogenesis the moon place, pliable and tough as skin.Person in raw GUWA, name Herba Lepisori Thunbergiani, controls pouring also good." " book on Chinese herbal medicine is high former ": " Folium Pyrrosiae cures mainly consumptive fever pathogen person, and consumptive fever is at bone, and pathogen is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid difficulty in urinations, dysuria also.Folium Pyrrosiae helps the vital essence of lung kidney, and upper downcrossings, crystal is moistened, then the outer key of upper orifices is all logical, changes under lung qi, then capable the and normal urination of water channel." function relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle.

Ramulus et Folium Bauhiniae Faberi: mildly bitter flavor, micro-acid, cool in nature, return liver, lung, large intestine channel.There is heat-clearing and toxic substances removing, effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.

Herba Saxifragae: micro-bitter, acrid, cold, slightly poisonous; Enter lung, spleen, large intestine three warp.Dispel the wind, heat clearing away, removing pathogenic heat from blood and toxic substance from the body.Control rubella, eczema, otitis media, erysipelas, cough, spit blood, lung abscess, metrorrhagia, haemorrhoids.Compendium of Material Medica: " control pestilence, beat wine clothes.Vomiting and diarrhea people is used in life, and ripe use is emesis profit then.Control again Ting ear, smash juice and drip it." " the SHENGCAO property of medicine standby want ": " control in ear sudden high fever poison, redness is suppurated pain, beats juice instillation ear, or adds Borneolum Syntheticum and dissipate and heal.”

Herba Moslae: this product is the dry aerial parts of labiate Mosla chinensis Maxim..Pungent, tepor.Attach to the lung and stomach meridians.Relieving the exterior syndrome by diaphoresis, and middle dampness removing.For summer-heat damp cold, fever with aversion to cold, has a headache lossless, and stomachache is vomited and diarrhoea, dysuria.

Caulis Vernoniae Andersonii: toil, tepor.Expelling pathogenic wind from the body surface, relaxing muscles and tendons to promote blood circulation.Cure cold, malaria, rheumatic arthralgia, traumatic injury, laryngalgia, toothache.

Cacumen Tamaricis: this product is the delicate branch and leaf of drying of Tamaricaceae Ramulus et Folium Tamaricis.Sweet, pungent, flat.GUIXIN, lung, stomach warp.Loose wind, induces sweat, rash.For measles without adequate eruption, rheumatic arthralgia.

Fructus Arctii: acrid in the mouth is bitter, cold in nature; Return lung, stomach warp.Can dispelling wind and heat pathogens; Heat-clearing and toxic substances removing rash; Lung qi dispersing sore-throat relieving is loose swollen.Cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; Sore swollen toxin and mumps etc.

Semen Brassicae Campestris: be the young stem and leaf of crucifer Brassica campestris L.Pungent, cool.Enter lung, liver, spleen.Loose blood, detumescence.The logical intestinal of broken knot, controls over-strained hemoptysis, dysentery, erysipelas, pyretic toxicity skin ulcer, acute mastitis.

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".

Stir-baked SQUAMA MANITIS: salty in the mouth, cold nature; Return liver, stomach warp.Blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control mange carbuncle poison, dispelling the stagnated QI promoting the circulation of blood, chest and diaphragm expands against gas, controls bladder hernia pain." Compendium of Material Medica: " and except intermittent fever due to phlegm cold and heat, the tetanic pain of migratory arthralgia, qualcomm meridian, lower milk, subduing inflammation, evacuation of pus blood, sensible parasite killing." blood circulation promoting and dispersing pathogen accumulation, stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula.Flos Rosae Chinensis: sweet, temperature.Return Liver Channel.Promoting blood flow to regulate menstruation, loose poison detumescence.Flower: for menoxenia, dysmenorrhea, carbuncle furuncle and phyma poison, tuberculous lymphadenitis (non-diabrosis).Leaf: tuberculous lymphadenitis, traumatic injury.Root: traumatic injury, leucorrhea, seminal emission.

Coleseed: be the seed of crucifer Brassica campestris L.Pungent; Sweet; Flat.Return liver; Kidney channel.Blood circulation promoting and blood stasis dispelling; Dispersing swelling and dissipating binds; Loosening bowel to relieve constipation.Main prolonged lochia; Abdominal pain due to blood stasis; Dysmenorrhea; Discharging fresh blood stool; Dysentery; Fengshi Guanjie swells and ache; Carbuncle erysipelas; Acute mastitis; Constipation; Adhesive ileus.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.

Radix Trichosanthis: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis." book on Chinese herbal medicine justice ": " medicine so-called Radix Trichosanthis person wantonly, namely cuts into slices with it with the root that withers, have the name of powder, real without powder.It smashes the method for thin clear powder." " book on Chinese herbal medicine is looked for the truth ": " and Radix Trichosanthis, than Fructus Trichosanthis, its property is slightly flat, seemingly do not wither impatient compel, and have push away wall fall wall merit also.There is speech regulating the spleen and stomach absolutely continuous to " warp ", say like anon-normal, but its evanescence of heat of cloud is from the meaning of peace." for calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.

The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.

Radix Boehmeriae: cold, sweet in the mouth.Staff, meridian of Foot-TAI YIN.Clearing away heat and promoting diuresis, antiabortive hemostasis, removing toxic substances.Swell and ache for cold, fever, measles hyperpyrexia, urinary tract infection, oedema due to nephritis, anemia of pregnant woman's stomachache, frequent fetal movement, threatened abortion, traumatic injury, fracture, skin infection, hemorrhage.

Fructus Mori: be the fruit ear of moraceae plants Mulberry.Sweet; Acid; Cold in nature.Return liver; Kidney channel.Nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.

Mao mao Radix Crotalariae szemoensis: be the Seedling of grass Phyllostachys pubescens Mazei ex H.de Lebaie.Sweet; Cold.Reduce phlegm; Relieving distension; Rash.Abdominal distention is amassed in main meal products shop; Varioliform exanthema does not go out.

Radix Rehmanniae: another name ground marrow (" herbal classic "), Proterozoic (" book on Chinese herbal medicine justice "), dry Radix Rehmanniae (" Chinese medicinal herbal ").Sweetness and bitterness, cool.Enter the heart, liver, kidney channel.YIN nourishing, nourishes blood.Control fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon hinders constipation.

Radix Scutellariae: property is bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri is best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so house Radix Scutellariae can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section half exterior and half interior, agent is also." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Rhizoma Atractylodis Macrocephalae (parched): sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.

Folium Persicae: bitter is flat.Heat-clearing and toxic substances removing, killing parasites for relieving itching.For malaria, carbuncle furuncle, hemorrhoid, eczema, trichomonas vaginitis.

Folium eucalypti globueli (Eucalyptus globulus Labill.): be the leaf of myrtle Eucalyptus globulus Labill.Toil, cool.Dispelling wind to relieve the exterior syndrome; Heat-clearing and toxic substances removing; Phlegm-eliminiating and qi-regulating; Killing parasites for relieving itching.Main flu; High dyspnea of heat type is coughed; Pertussis; Abdominal distention; Diarrhoea; Dysentery; Hook; Filaricide; Malaria; Rheumatalgia; Eczema; Scabies; Burn and scald; Traumatic hemorrhage.Cure cold, influenza, dysentery, enteritis, arthralgia, cystitis, scalds, scabies, erysipelas, neurodermatitis, eczema, carbuncle pyogenic infections from tumour or sore.

Radix Glycyrrhizae: nature and flavor are sweet is flat.Enter spleen, stomach, lung meridian.Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

For solving the problems of the technologies described above, the invention provides a kind of medicine for the treatment of damp-heat acute eczema, pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, sublimed preparation, solution, injection, suppository, plaster, syrup, powder, liniment, enema and patch.

Medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, within every 8 days, is a course for the treatment of; When this Chinese medicine composition is spray use, 3-5 time on the one every 10 days is a course for the treatment of; When this Chinese medicine composition is liniment, patch use, 2 times on the one every 9 days is a course for the treatment of.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 ointment of the present invention

Get Herba Violae 9g, Radix Semiaquilegiae 11g, Ramulus Uncariae Cum Uncis 13g, Citrullus vulgaris Cui clothing 24g, Herba Andrographis 19g, Rhizoma Smilacis Glabrae 20g, Herba Taraxaci 14g, Folium Pyrrosiae 13g, Ramulus et Folium Bauhiniae Faberi 24g, Herba Saxifragae 25g, Herba Moslae 26g, Caulis Vernoniae Andersonii 5g, Cacumen Tamaricis 23g, Fructus Arctii 19g, Semen Brassicae Campestris 13g, Radix Platycodonis 20g, stir-baked SQUAMA MANITIS 11g, Flos Rosae Chinensis 24g, coleseed 19g, Rhizoma Curcumae 15g, Radix Trichosanthis 19g, Rhizoma Anemarrhenae 25g, Radix Boehmeriae 26g, Fructus Mori 21g, Caulis Bambusae Germinatus 12g, Radix Rehmanniae 32g, Radix Scutellariae 25g, Rhizoma Atractylodis Macrocephalae (parched) 40g, Folium Persicae 26g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 27g and Radix Glycyrrhizae 12g.

Its preparation method comprises the following steps:

By described raw medicinal material in described ratio mixing immersion 1 hour, be then placed in multi-function extractor, first time decocts 6 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 9 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.08MPa, temperature remains on 70 DEG C, and being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C, cooling, tinning after ultraviolet radiation sterilizing.

Embodiment 2 spray of the present invention

Get Herba Violae 13g, Radix Semiaquilegiae 7g, Ramulus Uncariae Cum Uncis 10g, Citrullus vulgaris Cui clothing 19g, Herba Andrographis 17g, Rhizoma Smilacis Glabrae 18g, Herba Taraxaci 11g, Folium Pyrrosiae 15g, Ramulus et Folium Bauhiniae Faberi 21g, Herba Saxifragae 19g, Herba Moslae 28g, Caulis Vernoniae Andersonii 7g, Cacumen Tamaricis 18g, Fructus Arctii 21g, Semen Brassicae Campestris 15g, Radix Platycodonis 16g, stir-baked SQUAMA MANITIS 13g, Flos Rosae Chinensis 22g, coleseed 22g, Rhizoma Curcumae 17g, Radix Trichosanthis 20g, Rhizoma Anemarrhenae 16g, Radix Boehmeriae 27g, Fructus Mori 24g, Caulis Bambusae Germinatus 16g, Radix Rehmanniae 35g, Radix Scutellariae 31g, Rhizoma Atractylodis Macrocephalae (parched) 38g, Folium Persicae 24g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24g and Radix Glycyrrhizae 7g.

Its preparation method comprises the following steps:

A, take all raw medicinal materials in described ratio, add the water soaking 5 hours relative to the mixture quality 4 times obtained, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, decocts 3 times, merges decoction liquor and filter, filtrate heats to obtain extractum 1, and medicinal residues are for subsequent use;

B, the medicinal residues of step a are added 90% soak with ethanol 1 hour, extract twice, each 2 hours, merge extractive liquid, 160 orders filter, get 10000 revs/min centrifugal after supernatant, be the ultrafiltration post ultrafiltration of 10000 through the molecular weight that dams, ultrafiltrate concentrating under reduced pressure obtains the extractum 2 of when relative density is 80 DEG C 1.35;

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

Embodiment 3 liniment of the present invention

Get Herba Violae 11g, Radix Semiaquilegiae 9g, Ramulus Uncariae Cum Uncis 15g, Citrullus vulgaris Cui clothing 22g, Herba Andrographis 13g, Rhizoma Smilacis Glabrae 22g, Herba Taraxaci 16g, Folium Pyrrosiae 17g, Ramulus et Folium Bauhiniae Faberi 15g, Herba Saxifragae 22g, Herba Moslae 23g, Caulis Vernoniae Andersonii 9g, Cacumen Tamaricis 21g, Fructus Arctii 15g, Semen Brassicae Campestris 11g, Radix Platycodonis 24g, stir-baked SQUAMA MANITIS 9g, Flos Rosae Chinensis 19g, coleseed 18g, Rhizoma Curcumae 25g, Radix Trichosanthis 15g, Rhizoma Anemarrhenae 23g, Radix Boehmeriae 23g, Fructus Mori 17g, Caulis Bambusae Germinatus 14g, Radix Rehmanniae 26g, Radix Scutellariae 30g, Rhizoma Atractylodis Macrocephalae (parched) 32g, Folium Persicae 28g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25g and Radix Glycyrrhizae 11g.

Its preparation method comprises the following steps:

Embodiment 4 granule of the present invention

Its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 95%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.10, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.2 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Toxicity test:

Acute skin irritation test:

These product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the liniment prepared by embodiments of the invention 3 to be directly coated on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.

Hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group ointment of the embodiment of the present invention 1.The ointment 0.1g getting the embodiment of the present invention 1 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Hypersensitive test:

Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group spray of the embodiment of the present invention 1.Get the spray of the embodiment of the present invention 2 in unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, spray this product 1 time at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 4 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore the granule acute toxicity of the embodiment of the present invention 4 is low, clinical drug safety.

Clinical data:

This organizes 236 routine damp-heat acute eczema patients, man 134 example, female 102 example; In age 24-62 year, average 39 years old: be divided into four groups at random, four groups, at age, sex and course of disease no significant difference (P > 0.05), had comparability.

Ointment+Granules in Treating group: 59 people, male 34 people, female 25 people.

Spray+Granules in Treating group: 59 people, male 34 people, female 25 people.

Liniment+Granules in Treating group: 59 people, male 33 people, female 26 people.

Western medicine group: 59 people, male 33 people, female 26 people.

Diagnostic criteria:

Western medicine diagnose standard

Draft as follows with reference to " clinical dermatology ", " skin cypridology " (the 7th edition) to acute eczema diagnostic criteria:

Acute eczema: morbidity is anxious, and can send out any position in health, often symmetrical, skin lesion is pleomorphism, visible erythema, pimple, vesicle, ooze out, erosion, incrustation etc., constant kind skin lesion is also deposited, and pruritus is obvious.

Standards of Chinese Medical Syndrome Differentiation:

All meet above standard be diagnosed as acute eczema, Chinese medical discrimination is damp-heat type.

Therapeutic Method:

Ointment+Granules in Treating group: the granule of the oral embodiment of the present invention 4, every day 3 times, one time 1 bag; Ointment prepared by the embodiment of the present invention 1 of external simultaneously smears affected part, every day 2 times; It within every 7 days, is 1 course for the treatment of.

Spray+Granules in Treating group: the granule of the oral embodiment of the present invention 4, every day 3 times, one time 1 bag; Spray spraying affected part prepared by the embodiment of the present invention 2 of external simultaneously, every day 3 times; It within every 7 days, is 1 course for the treatment of;

Liniment+Granules in Treating group: the granule of the oral embodiment of the present invention 4, every day 3 times, one time 1 bag; Liniment prepared by the embodiment of the present invention 3 of external simultaneously smears affected part, every day 2 times; It within every 7 days, is 1 course for the treatment of;

Western medicine group: chlorphenamine, oral 4mg/ time, 3 times/d; 10% calcium gluconate 10ml intravenous injection, 1 time/d; Vitamin C 1 ~ 2g intravenous injection, 1 time/d; The zinc ointment of external simultaneously smears affected part, every day 2 times; 7 days 1 courses for the treatment of.

All treat two courses for the treatment of for four groups.

Efficacy assessment standard:

Clinical cure: skin lesion disappears completely or only stays pigmentation, subjective symptoms disappears;

Effective: skin lesion disappears more than 60%, subjective symptoms obviously alleviates or disappears;

Effective: skin lesion disappears more than 30%, and subjective symptoms alleviates;

Invalid: skin lesion disappears less than 30%.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy damp-heat acute eczema of the present invention, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy damp-heat acute eczema of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After table 1 Four composition does not treat 2 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Clinical cure	Effective	Effectively	Invalid	Total effective rate
							Ointment+Granules in Treating group	59	37	19	3	0	100%
Spray+Granules in Treating group	59	36	18	5	0	100%
							Liniment+Granules in Treating group	59	36	19	4	0	100%
Western medicine group	59	23	11	14	11	81.4%

Table 2 Four composition do not treat 2 the course for the treatment of clinical cure and effective number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of
				Ointment+Granules in Treating group	56	32(57.1%)	24(42.9%)
Spray+Granules in Treating group	54	31(57.4%)	23(42.6%)
				Liniment+Granules in Treating group	55	33(60.0%)	22(40.0%)
Western medicine group	34	11(32.4%)	23(67.6%)

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Simultaneously to ointment+Granules in Treating group clinical cure and effective 56 examples, spray+Granules in Treating group clinical cure and effective 54 examples, liniment+Granules in Treating group clinical cure and effective 55 examples, and western medicine group clinical cure and effective 34 routine follow-up of patients 1 year, result is added up:

Ointment+Granules in Treating group clinical cure and effective 56 examples, 37 example nothing recurrences of clinical cure, effective 19 routine 1 case relapseds, relapse rate is 1.8%;

Spray+Granules in Treating group clinical cure and effective 54 examples, 36 example nothing recurrences of clinical cure, effective 18 routine 1 case relapseds, relapse rate is 1.9%;

Liniment+Granules in Treating group clinical cure and effective 55 examples, 36 example nothing recurrences of clinical cure, effective 19 routine 1 case relapseds, relapse rate is 1.8%;

Western medicine group clinical cure and effective 34 examples, 23 example recurrence 3 examples of clinical cure, recur 8 examples in 11 effective examples, relapse rate is 32.4%.

Model case: Lee, man, 38 years old, time medical, women's head-ornaments erythra, violent pruritus, have erythema inside upper limb, erythema has syringe needle arrive pimple, the papulovesicle of foxtail millet grain size, there is phlysis at serious position, readme has violent pruritus and burning sensation, accompanies vexed, thirsty, yellowish urine, large dry stool, red tongue, yellow and greasy fur, slippery and rapid pulse.Be diagnosed as acute eczema, Chinese medical discrimination is damp-heat type.The granule of the oral embodiment of the present invention 4, every day 3 times, one time 1 bag; Ointment prepared by the embodiment of the present invention 1 of external simultaneously smears affected part, every day 2 times, and treat phlysis drying shrinkage after 4 days, pimple, papulovesicle obviously reduce, and treat 7 days clinical cures, follow up a case by regular visits to and do not recur for 1 year.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of damp-heat acute eczema for one kind, it is characterized in that, comprise following raw medicinal material: Herba Violae, Radix Semiaquilegiae, Ramulus Uncariae Cum Uncis, Citrullus vulgaris Cui clothing, Herba Andrographis, Rhizoma Smilacis Glabrae, Herba Taraxaci, Folium Pyrrosiae, Ramulus et Folium Bauhiniae Faberi, Herba Saxifragae, Herba Moslae, Caulis Vernoniae Andersonii, Cacumen Tamaricis, Fructus Arctii, Semen Brassicae Campestris, Radix Platycodonis, stir-baked SQUAMA MANITIS, Flos Rosae Chinensis, coleseed, Rhizoma Curcumae, Radix Trichosanthis, the Rhizoma Anemarrhenae, Radix Boehmeriae, Fructus Mori, Caulis Bambusae Germinatus, Radix Rehmanniae, Radix Scutellariae, Rhizoma Atractylodis Macrocephalae (parched), Folium Persicae, Folium eucalypti globueli (Eucalyptus globulus Labill.) and Radix Glycyrrhizae.

2. medicine according to claim 1, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 7-15 weight portion, Radix Semiaquilegiae 6-13 weight portion, Ramulus Uncariae Cum Uncis 9-17 weight portion, Citrullus vulgaris Cui clothing 17-26 weight portion, Herba Andrographis 11-21 weight portion, Rhizoma Smilacis Glabrae 15-25 weight portion, Herba Taraxaci 10-17 weight portion, Folium Pyrrosiae 12-18 weight portion, Ramulus et Folium Bauhiniae Faberi 12-27 weight portion, Herba Saxifragae 16-28 weight portion, Herba Moslae 21-30 weight portion, Caulis Vernoniae Andersonii 4-10 weight portion, Cacumen Tamaricis 15-25 weight portion, Fructus Arctii 13-23 weight portion, Semen Brassicae Campestris 9-17 weight portion, Radix Platycodonis 12-29 weight portion, stir-baked SQUAMA MANITIS 8-16 weight portion, Flos Rosae Chinensis 17-29 weight portion, coleseed 16-24 weight portion, Rhizoma Curcumae 12-28 weight portion, Radix Trichosanthis 14-25 weight portion, Rhizoma Anemarrhenae 13-27 weight portion, Radix Boehmeriae 21-29 weight portion, Fructus Mori 15-28 weight portion, Caulis Bambusae Germinatus 10-18 weight portion, Radix Rehmanniae 23-38 weight portion, Radix Scutellariae 23-35 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 30-42 weight portion, Folium Persicae 22-30 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 23-29 weight portion and Radix Glycyrrhizae 6-13 weight portion.

3. medicine according to claim 1, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 9-13 weight portion, Radix Semiaquilegiae 7-11 weight portion, Ramulus Uncariae Cum Uncis 10-15 weight portion, Citrullus vulgaris Cui clothing 19-24 weight portion, Herba Andrographis 13-19 weight portion, Rhizoma Smilacis Glabrae 18-22 weight portion, Herba Taraxaci 11-16 weight portion, Folium Pyrrosiae 13-17 weight portion, Ramulus et Folium Bauhiniae Faberi 15-24 weight portion, Herba Saxifragae 19-25 weight portion, Herba Moslae 23-28 weight portion, Caulis Vernoniae Andersonii 5-9 weight portion, Cacumen Tamaricis 18-23 weight portion, Fructus Arctii 15-21 weight portion, Semen Brassicae Campestris 11-15 weight portion, Radix Platycodonis 16-24 weight portion, stir-baked SQUAMA MANITIS 9-13 weight portion, Flos Rosae Chinensis 19-24 weight portion, coleseed 18-22 weight portion, Rhizoma Curcumae 15-25 weight portion, Radix Trichosanthis 15-20 weight portion, Rhizoma Anemarrhenae 16-25 weight portion, Radix Boehmeriae 23-27 weight portion, Fructus Mori 17-24 weight portion, Caulis Bambusae Germinatus 12-16 weight portion, Radix Rehmanniae 26-35 weight portion, Radix Scutellariae 25-31 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 32-40 weight portion, Folium Persicae 24-28 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24-27 weight portion and Radix Glycyrrhizae 7-12 weight portion.

4. the medicine according to claims 1 to 3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 9 weight portion, Radix Semiaquilegiae 11 weight portion, Ramulus Uncariae Cum Uncis 13 weight portion, Citrullus vulgaris Cui clothing 24 weight portion, Herba Andrographis 19 weight portion, Rhizoma Smilacis Glabrae 20 weight portion, Herba Taraxaci 14 weight portion, Folium Pyrrosiae 13 weight portion, Ramulus et Folium Bauhiniae Faberi 24 weight portion, Herba Saxifragae 25 weight portion, Herba Moslae 26 weight portion, Caulis Vernoniae Andersonii 5 weight portion, Cacumen Tamaricis 23 weight portion, Fructus Arctii 19 weight portion, Semen Brassicae Campestris 13 weight portion, Radix Platycodonis 20 weight portion, stir-baked SQUAMA MANITIS 11 weight portion, Flos Rosae Chinensis 24 weight portion, coleseed 19 weight portion, Rhizoma Curcumae 15 weight portion, Radix Trichosanthis 19 weight portion, the Rhizoma Anemarrhenae 25 weight portion, Radix Boehmeriae 26 weight portion, Fructus Mori 21 weight portion, Caulis Bambusae Germinatus 12 weight portion, Radix Rehmanniae 32 weight portion, Radix Scutellariae 25 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 40 weight portion, Folium Persicae 26 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 27 weight portion and Radix Glycyrrhizae 12 weight portion.

5. according to the arbitrary described medicine of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 13 weight portion, Radix Semiaquilegiae 7 weight portion, Ramulus Uncariae Cum Uncis 10 weight portion, Citrullus vulgaris Cui clothing 19 weight portion, Herba Andrographis 17 weight portion, Rhizoma Smilacis Glabrae 18 weight portion, Herba Taraxaci 11 weight portion, Folium Pyrrosiae 15 weight portion, Ramulus et Folium Bauhiniae Faberi 21 weight portion, Herba Saxifragae 19 weight portion, Herba Moslae 28 weight portion, Caulis Vernoniae Andersonii 7 weight portion, Cacumen Tamaricis 18 weight portion, Fructus Arctii 21 weight portion, Semen Brassicae Campestris 15 weight portion, Radix Platycodonis 16 weight portion, stir-baked SQUAMA MANITIS 13 weight portion, Flos Rosae Chinensis 22 weight portion, coleseed 22 weight portion, Rhizoma Curcumae 17 weight portion, Radix Trichosanthis 20 weight portion, the Rhizoma Anemarrhenae 16 weight portion, Radix Boehmeriae 27 weight portion, Fructus Mori 24 weight portion, Caulis Bambusae Germinatus 16 weight portion, Radix Rehmanniae 35 weight portion, Radix Scutellariae 31 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 38 weight portion, Folium Persicae 24 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 24 weight portion and Radix Glycyrrhizae 7 weight portion.

6. according to the arbitrary described medicine of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Violae 11 weight portion, Radix Semiaquilegiae 9 weight portion, Ramulus Uncariae Cum Uncis 15 weight portion, Citrullus vulgaris Cui clothing 22 weight portion, Herba Andrographis 13 weight portion, Rhizoma Smilacis Glabrae 22 weight portion, Herba Taraxaci 16 weight portion, Folium Pyrrosiae 17 weight portion, Ramulus et Folium Bauhiniae Faberi 15 weight portion, Herba Saxifragae 22 weight portion, Herba Moslae 23 weight portion, Caulis Vernoniae Andersonii 9 weight portion, Cacumen Tamaricis 21 weight portion, Fructus Arctii 15 weight portion, Semen Brassicae Campestris 11 weight portion, Radix Platycodonis 24 weight portion, stir-baked SQUAMA MANITIS 9 weight portion, Flos Rosae Chinensis 19 weight portion, coleseed 18 weight portion, Rhizoma Curcumae 25 weight portion, Radix Trichosanthis 15 weight portion, the Rhizoma Anemarrhenae 23 weight portion, Radix Boehmeriae 23 weight portion, Fructus Mori 17 weight portion, Caulis Bambusae Germinatus 14 weight portion, Radix Rehmanniae 26 weight portion, Radix Scutellariae 30 weight portion, Rhizoma Atractylodis Macrocephalae (parched) 32 weight portion, Folium Persicae 28 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 25 weight portion and Radix Glycyrrhizae 11 weight portion.

7., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is ointment, its preparation method comprises the following steps:

8., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is spray, its preparation method comprises the following steps:

C, extractum 1 and extractum 2 are mixed, namely thin up obtains spray.

9., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is liniment, its preparation method comprises the following steps:

10., according to the arbitrary described medicine of claim 1-6, it is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps: